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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FGD4-DNM1L (FusionGDB2 ID:30163)

Fusion Gene Summary for FGD4-DNM1L

Fusion gene summary

Fusion gene information	Fusion gene name: FGD4-DNM1L
	Fusion gene ID: 30163
		Hgene	Tgene
	Gene symbol	FGD4	DNM1L
	Gene ID	121512	10059
	Gene name	FYVE, RhoGEF and PH domain containing 4	dynamin 1 like
	Synonyms	CMT4H\|FRABP\|ZFYVE6	DLP1\|DRP1\|DVLP\|DYMPLE\|EMPF\|EMPF1\|HDYNIV\|OPA5
	Cytomap	12p11.21	12p11.21
	Type of gene	protein-coding	protein-coding
	Description	FYVE, RhoGEF and PH domain-containing protein 4FGD1 family, member 4FGD1-related F-actin-binding proteinactin-filament binding protein frabinzinc finger FYVE domain-containing protein 6	dynamin-1-like proteinDnm1p/Vps1p-like proteindynamin family member proline-rich carboxyl-terminal domain lessdynamin-like protein 4dynamin-like protein IVdynamin-related protein 1
	Modification date	20200328	20200327
	UniProtAcc	Q96M96	O00429
	Ensembl transtripts involved in fusion gene	ENST00000534526, ENST00000266482, ENST00000381025, ENST00000427716, ENST00000472289, ENST00000473513, ENST00000525053, ENST00000531134, ENST00000546442,	ENST00000266481, ENST00000381000, ENST00000414834, ENST00000547312, ENST00000548671, ENST00000358214, ENST00000452533, ENST00000549701, ENST00000553257,
Fusion gene scores	* DoF score	19 X 13 X 13=3211	10 X 9 X 8=720
	# samples	22	13
	** MAII score	log2(22/3211*10)=-3.86744723620111 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FGD4 [Title/Abstract] AND DNM1L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DNM1L(32884877)-FGD4(32791589), # samples:3 FGD4(32552893)-DNM1L(32884788), # samples:1 FGD4(32686506)-DNM1L(32849706), # samples:1
Anticipated loss of major functional domain due to fusion event.	FGD4-DNM1L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FGD4-DNM1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. DNM1L-FGD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DNM1L-FGD4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DNM1L	GO:0000266	mitochondrial fission	23530241
Tgene	DNM1L	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	11514614\|23530241
Tgene	DNM1L	GO:0016559	peroxisome fission	12618434
Tgene	DNM1L	GO:0050714	positive regulation of protein secretion	9570752
Tgene	DNM1L	GO:0061025	membrane fusion	20850011
Tgene	DNM1L	GO:0065003	protein-containing complex assembly	20850011
Tgene	DNM1L	GO:0090149	mitochondrial membrane fission	11514614

Fusion gene breakpoints across FGD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DNM1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-38-4630-01A	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
ChiTaRS5.0	N/A	AA714282	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+

Top

Fusion Gene ORF analysis for FGD4-DNM1L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000534526	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
5CDS-intron	ENST00000534526	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
5CDS-intron	ENST00000534526	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
5CDS-intron	ENST00000534526	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
5CDS-intron	ENST00000534526	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
Frame-shift	ENST00000534526	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
Frame-shift	ENST00000534526	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
Frame-shift	ENST00000534526	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
Frame-shift	ENST00000534526	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000266482	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000266482	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000266482	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000266482	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000381025	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000381025	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000381025	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000381025	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000427716	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000427716	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000427716	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000427716	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000472289	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000472289	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000472289	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000472289	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000473513	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000473513	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000473513	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000473513	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000525053	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000525053	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000525053	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000525053	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000531134	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000531134	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000531134	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000531134	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000546442	ENST00000358214	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000546442	ENST00000452533	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000546442	ENST00000549701	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-3CDS	ENST00000546442	ENST00000553257	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000266482	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000266482	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000266482	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000266482	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000266482	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000266482	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000266482	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000381025	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000381025	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000381025	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000381025	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000381025	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000381025	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000427716	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000427716	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000427716	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000427716	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000427716	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000427716	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000472289	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000472289	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000472289	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000472289	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000472289	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000472289	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000473513	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000473513	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000473513	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000473513	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000473513	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000473513	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000525053	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000525053	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000525053	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000525053	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000525053	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000525053	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000531134	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000531134	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000531134	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000531134	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000531134	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000531134	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000534526	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000266481	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000546442	ENST00000266481	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000358214	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000381000	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000546442	ENST00000381000	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000414834	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000546442	ENST00000414834	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000452533	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000547312	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000546442	ENST00000547312	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000548671	FGD4	chr12	32552893	+	DNM1L	chr12	32884788	+
intron-intron	ENST00000546442	ENST00000548671	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000549701	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+
intron-intron	ENST00000546442	ENST00000553257	FGD4	chr12	32686506	+	DNM1L	chr12	32849706	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for FGD4-DNM1L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FGD4	chr12	32552893	+	DNM1L	chr12	32884787	+	4.55E-09	1
FGD4	chr12	32552893	+	DNM1L	chr12	32884787	+	4.55E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FGD4-DNM1L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32884877/:32791589)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FGD4 Q96M96	DNM1L O00429
FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:15133042}.	FUNCTION: Functions in mitochondrial and peroxisomal division (PubMed:9570752, PubMed:9786947, PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17553808, PubMed:17460227, PubMed:18695047, PubMed:18838687, PubMed:19638400, PubMed:19411255, PubMed:19342591, PubMed:23921378, PubMed:23283981, PubMed:23530241, PubMed:29478834, PubMed:32484300, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23921378, PubMed:23283981, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:9570752, PubMed:20688057, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250\|UniProtKB:Q8K1M6, ECO:0000269\|PubMed:11514614, ECO:0000269\|PubMed:12499366, ECO:0000269\|PubMed:17015472, ECO:0000269\|PubMed:17301055, ECO:0000269\|PubMed:17460227, ECO:0000269\|PubMed:17553808, ECO:0000269\|PubMed:18695047, ECO:0000269\|PubMed:18838687, ECO:0000269\|PubMed:19342591, ECO:0000269\|PubMed:19411255, ECO:0000269\|PubMed:19638400, ECO:0000269\|PubMed:20688057, ECO:0000269\|PubMed:22265414, ECO:0000269\|PubMed:23283981, ECO:0000269\|PubMed:23530241, ECO:0000269\|PubMed:23584531, ECO:0000269\|PubMed:23792689, ECO:0000269\|PubMed:23921378, ECO:0000269\|PubMed:26992161, ECO:0000269\|PubMed:27145208, ECO:0000269\|PubMed:27301544, ECO:0000269\|PubMed:27328748, ECO:0000269\|PubMed:29478834, ECO:0000269\|PubMed:29899447, ECO:0000269\|PubMed:32484300, ECO:0000269\|PubMed:9570752, ECO:0000269\|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269\|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269\|PubMed:12618434}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for FGD4-DNM1L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FGD4-DNM1L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FGD4-DNM1L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FGD4-DNM1L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source