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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:FGD4-LRRK2 (FusionGDB2 ID:30168)

Fusion Gene Summary for FGD4-LRRK2

Fusion gene summary

Fusion gene information	Fusion gene name: FGD4-LRRK2
	Fusion gene ID: 30168
		Hgene	Tgene
	Gene symbol	FGD4	LRRK2
	Gene ID	121512	120892
	Gene name	FYVE, RhoGEF and PH domain containing 4	leucine rich repeat kinase 2
	Synonyms	CMT4H\|FRABP\|ZFYVE6	AURA17\|DARDARIN\|PARK8\|RIPK7\|ROCO2
	Cytomap	12p11.21	12q12
	Type of gene	protein-coding	protein-coding
	Description	FYVE, RhoGEF and PH domain-containing protein 4FGD1 family, member 4FGD1-related F-actin-binding proteinactin-filament binding protein frabinzinc finger FYVE domain-containing protein 6	leucine-rich repeat serine/threonine-protein kinase 2augmented in rheumatoid arthritis 17
	Modification date	20200328	20200329
	UniProtAcc	Q96M96	Q5S007
	Ensembl transtripts involved in fusion gene	ENST00000534526, ENST00000266482, ENST00000381025, ENST00000427716, ENST00000472289, ENST00000473513, ENST00000525053, ENST00000531134, ENST00000546442,	ENST00000481256, ENST00000298910, ENST00000343742,
Fusion gene scores	* DoF score	19 X 13 X 13=3211	3 X 3 X 2=18
	# samples	22	3
	** MAII score	log2(22/3211*10)=-3.86744723620111 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FGD4 [Title/Abstract] AND LRRK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FGD4(32552893)-LRRK2(40619357), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LRRK2	GO:0000165	MAPK cascade	17200152
Tgene	LRRK2	GO:0000186	activation of MAPKK activity	19302196
Tgene	LRRK2	GO:0001934	positive regulation of protein phosphorylation	22012985
Tgene	LRRK2	GO:0006468	protein phosphorylation	25500533
Tgene	LRRK2	GO:0010955	negative regulation of protein processing	21370995
Tgene	LRRK2	GO:0018105	peptidyl-serine phosphorylation	19576176
Tgene	LRRK2	GO:0018107	peptidyl-threonine phosphorylation	21048939
Tgene	LRRK2	GO:0031398	positive regulation of protein ubiquitination	16352719\|20173330
Tgene	LRRK2	GO:0032092	positive regulation of protein binding	21370995
Tgene	LRRK2	GO:0034260	negative regulation of GTPase activity	22423108
Tgene	LRRK2	GO:0043068	positive regulation of programmed cell death	17200152
Tgene	LRRK2	GO:0046039	GTP metabolic process	21048939
Tgene	LRRK2	GO:0046777	protein autophosphorylation	16269541\|16321986\|17200152\|17442267
Tgene	LRRK2	GO:1902499	positive regulation of protein autoubiquitination	16352719
Tgene	LRRK2	GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	21850687
Tgene	LRRK2	GO:1903215	negative regulation of protein targeting to mitochondrion	21370995

Fusion gene breakpoints across FGD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0129-01A	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+

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Fusion Gene ORF analysis for FGD4-LRRK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000534526	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
In-frame	ENST00000534526	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
In-frame	ENST00000534526	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000266482	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000266482	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000381025	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000381025	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000427716	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000427716	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000472289	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000472289	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000473513	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000473513	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000525053	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000525053	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000531134	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000531134	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000546442	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-3CDS	ENST00000546442	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000266482	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000381025	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000427716	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000472289	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000473513	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000525053	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000531134	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+
intron-intron	ENST00000546442	ENST00000481256	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000534526

FGD4

chr12

32552893

ENST00000343742

LRRK2

chr12

40619357

4899

431

178

4095

1305

ENST00000534526

FGD4

chr12

32552893

ENST00000298910

LRRK2

chr12

40619357

9380

431

178

7863

2561

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000534526	ENST00000343742	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+	0.000284481	0.9997155
ENST00000534526	ENST00000298910	FGD4	chr12	32552893	-	LRRK2	chr12	40619357	+	0.00015402	0.999846

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Fusion Genomic Features for FGD4-LRRK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FGD4-LRRK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:32552893/chr12:40619357)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FGD4 Q96M96	LRRK2 Q5S007
FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:15133042}.	FUNCTION: Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815). {ECO:0000269\|PubMed:17114044, ECO:0000269\|PubMed:18230735, ECO:0000269\|PubMed:20949042, ECO:0000269\|PubMed:21850687, ECO:0000269\|PubMed:22012985, ECO:0000269\|PubMed:23395371, ECO:0000269\|PubMed:24687852, ECO:0000269\|PubMed:25201882, ECO:0000269\|PubMed:26014385, ECO:0000269\|PubMed:26824392, ECO:0000269\|PubMed:28720718, ECO:0000269\|PubMed:29125462, ECO:0000269\|PubMed:29127255, ECO:0000269\|PubMed:29212815, ECO:0000269\|PubMed:30398148, ECO:0000269\|PubMed:30635421}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

319_348

2528.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

728_731

2528.0

Compositional bias

Note=Poly-Leu

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1328_1511

2528.0

Domain

Roc

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1879_2138

2528.0

Domain

Protein kinase

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1341_1348

2528.0

Nucleotide binding

GTP

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1885_1893

2528.0

Nucleotide binding

ATP

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2098_2121

2528.0

Nucleotide binding

GTP

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2295_2298

2528.0

Nucleotide binding

GTP

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1012_1033

2528.0

Repeat

Note=LRR 2

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1036_1057

2528.0

Repeat

Note=LRR 3

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1059_1080

2528.0

Repeat

Note=LRR 4

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1084_1105

2528.0

Repeat

Note=LRR 5

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1108_1129

2528.0

Repeat

Note=LRR 6

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1130_1150

2528.0

Repeat

Note=LRR 7

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1174_1196

2528.0

Repeat

Note=LRR 8

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1197_1218

2528.0

Repeat

Note=LRR 9

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1221_1241

2528.0

Repeat

Note=LRR 10

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1246_1267

2528.0

Repeat

Note=LRR 11

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1269_1291

2528.0

Repeat

Note=LRR 12

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2139_2183

2528.0

Repeat

Note=WD 1

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2188_2228

2528.0

Repeat

Note=WD 2

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2233_2276

2528.0

Repeat

Note=WD 3

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2281_2327

2528.0

Repeat

Note=WD 4

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2333_2377

2528.0

Repeat

Note=WD 5

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2402_2438

2528.0

Repeat

Note=WD 6

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

2443_2497

2528.0

Repeat

Note=WD 7

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

983_1004

2528.0

Repeat

Note=LRR 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000381025

206_393

281.0

Domain

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000381025

422_521

281.0

Domain

PH 1

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000381025

643_740

281.0

Domain

PH 2

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000427716

206_393

767.0

Domain

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000427716

422_521

767.0

Domain

PH 1

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000427716

643_740

767.0

Domain

PH 2

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000381025

1_150

281.0

Region

Actin filament-binding

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000427716

1_150

767.0

Region

Actin filament-binding

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000381025

559_619

281.0

Zinc finger

FYVE-type

Hgene

FGD4

chr12:32552893

chr12:40619357

ENST00000427716

559_619

767.0

Zinc finger

FYVE-type

Tgene

LRRK2

chr12:32552893

chr12:40619357

ENST00000298910

1_969

2528.0

Region

Required for RAB29-mediated activation

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Fusion Gene Sequence for FGD4-LRRK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>30168_30168_1_FGD4-LRRK2_FGD4_chr12_32552893_ENST00000534526_LRRK2_chr12_40619357_ENST00000298910_length(transcript)=9380nt_BP=431nt
GGTAGCGGCTTTGAGTGAGTGCGGGAGCTGCAGATACCGAGACGCTGCGACTGCCGCAGGAGTCGCCGCAGCCAAACTCGCCGCGACGCC
GGGAGGGAGCGTACCGGGAAGGAGAGGGAGAGGAGGCACTCGCTGAGGAGACGCCGCAGTAGAGGGCGCCCCCGGAGTCGCGCCGAACCT
GGGCATGCAGGCGACGCCCCCCAGGGGCCGCTCGCGGCTGGACGGGAGCGGGAGGAGTCGGGGAGCGGCGGTCGAGCCCGGCAGGATGAG
CGACGAGGGCGGCTCCAACTTCAGGCGGGTGGCGATCCGGCGGAAGTCCAACCCCTCCTACCTGCCGCCCGGGGTGCCCCGGCCCTGGAG
CAGGCCCGCGTCGCACCTGGGACGTGTAGGGACCGCTGCCTTCAAGGGCCAGGTGCCCTCAGGAGCCACAGCCTCCAAGTTATTTCAAGG
CAAAAATATCCATGTGCCTCTGTTGATCGTCTTGGACTCCTATATGAGAGTCGCGAGTGTGCAGCAGGTGGGTTGGTCACTTCTGTGCAA
ATTAATAGAAGTCTGTCCAGGTACAATGCAAAGCTTAATGGGACCCCAGGATGTTGGAAATGATTGGGAAGTCCTTGGTGTTCACCAATT
GATTCTTAAAATGCTAACAGTTCATAATGCCAGTGTAAACTTGTCAGTGATTGGACTGAAGACCTTAGATCTCCTCCTAACTTCAGGTAA
AATCACCTTGCTGATATTGGATGAAGAAAGTGATATTTTCATGTTAATTTTTGATGCCATGCACTCATTTCCAGCCAATGATGAAGTCCA
GAAACTTGGATGCAAAGCTTTACATGTGCTGTTTGAGAGAGTCTCAGAGGAGCAACTGACTGAATTTGTTGAGAACAAAGATTATATGAT
ATTGTTAAGTGCGTTAACAAATTTTAAAGATGAAGAGGAAATTGTGCTTCATGTGCTGCATTGTTTACATTCCCTAGCGATTCCTTGCAA
TAATGTGGAAGTCCTCATGAGTGGCAATGTCAGGTGTTATAATATTGTGGTGGAAGCTATGAAAGCATTCCCTATGAGTGAAAGAATTCA
AGAAGTGAGTTGCTGTTTGCTCCATAGGCTTACATTAGGTAATTTTTTCAATATCCTGGTATTAAACGAAGTCCATGAGTTTGTGGTGAA
AGCTGTGCAGCAGTACCCAGAGAATGCAGCATTGCAGATCTCAGCGCTCAGCTGTTTGGCCCTCCTCACTGAGACTATTTTCTTAAATCA
AGATTTAGAGGAAAAGAATGAGAATCAAGAGAATGATGATGAGGGGGAAGAAGATAAATTGTTTTGGCTGGAAGCCTGTTACAAAGCATT
AACGTGGCATAGAAAGAACAAGCACGTGCAGGAGGCCGCATGCTGGGCACTAAATAATCTCCTTATGTACCAAAACAGTTTACATGAGAA
GATTGGAGATGAAGATGGCCATTTCCCAGCTCATAGGGAAGTGATGCTCTCCATGCTGATGCATTCTTCATCAAAGGAAGTTTTCCAGGC
ATCTGCGAATGCATTGTCAACTCTCTTAGAACAAAATGTTAATTTCAGAAAAATACTGTTATCAAAAGGAATACACCTGAATGTTTTGGA
GTTAATGCAGAAGCATATACATTCTCCTGAAGTGGCTGAAAGTGGCTGTAAAATGCTAAATCATCTTTTTGAAGGAAGCAACACTTCCCT
GGATATAATGGCAGCAGTGGTCCCCAAAATACTAACAGTTATGAAACGTCATGAGACATCATTACCAGTGCAGCTGGAGGCGCTTCGAGC
TATTTTACATTTTATAGTGCCTGGCATGCCAGAAGAATCCAGGGAGGATACAGAATTTCATCATAAGCTAAATATGGTTAAAAAACAGTG
TTTCAAGAATGATATTCACAAACTGGTCCTAGCAGCTTTGAACAGGTTCATTGGAAATCCTGGGATTCAGAAATGTGGATTAAAAGTAAT
TTCTTCTATTGTACATTTTCCTGATGCATTAGAGATGTTATCCCTGGAAGGTGCTATGGATTCAGTGCTTCACACACTGCAGATGTATCC
AGATGACCAAGAAATTCAGTGTCTGGGTTTAAGTCTTATAGGATACTTGATTACAAAGAAGAATGTGTTCATAGGAACTGGACATCTGCT
GGCAAAAATTCTGGTTTCCAGCTTATACCGATTTAAGGATGTTGCTGAAATACAGACTAAAGGATTTCAGACAATCTTAGCAATCCTCAA
ATTGTCAGCATCTTTTTCTAAGCTGCTGGTGCATCATTCATTTGACTTAGTAATATTCCATCAAATGTCTTCCAATATCATGGAACAAAA
GGATCAACAGTTTCTAAACCTCTGTTGCAAGTGTTTTGCAAAAGTAGCTATGGATGATTACTTAAAAAATGTGATGCTAGAGAGAGCGTG
TGATCAGAATAACAGCATCATGGTTGAATGCTTGCTTCTATTGGGAGCAGATGCCAATCAAGCAAAGGAGGGATCTTCTTTAATTTGTCA
GGTATGTGAGAAAGAGAGCAGTCCCAAATTGGTGGAACTCTTACTGAATAGTGGATCTCGTGAACAAGATGTACGAAAAGCGTTGACGAT
AAGCATTGGGAAAGGTGACAGCCAGATCATCAGCTTGCTCTTAAGGAGGCTGGCCCTGGATGTGGCCAACAATAGCATTTGCCTTGGAGG
ATTTTGTATAGGAAAAGTTGAACCTTCTTGGCTTGGTCCTTTATTTCCAGATAAGACTTCTAATTTAAGGAAACAAACAAATATAGCATC
TACACTAGCAAGAATGGTGATCAGATATCAGATGAAAAGTGCTGTGGAAGAAGGAACAGCCTCAGGCAGCGATGGAAATTTTTCTGAAGA
TGTGCTGTCTAAATTTGATGAATGGACCTTTATTCCTGACTCTTCTATGGACAGTGTGTTTGCTCAAAGTGATGACCTGGATAGTGAAGG
AAGTGAAGGCTCATTTCTTGTGAAAAAGAAATCTAATTCAATTAGTGTAGGAGAATTTTACCGAGATGCCGTATTACAGCGTTGCTCACC
AAATTTGCAAAGACATTCCAATTCCTTGGGGCCCATTTTTGATCATGAAGATTTACTGAAGCGAAAAAGAAAAATATTATCTTCAGATGA
TTCACTCAGGTCATCAAAACTTCAATCCCATATGAGGCATTCAGACAGCATTTCTTCTCTGGCTTCTGAGAGAGAATATATTACATCACT
AGACCTTTCAGCAAATGAACTAAGAGATATTGATGCCCTAAGCCAGAAATGCTGTATAAGTGTTCATTTGGAGCATCTTGAAAAGCTGGA
GCTTCACCAGAATGCACTCACGAGCTTTCCACAACAGCTATGTGAAACTCTGAAGAGTTTGACACATTTGGACTTGCACAGTAATAAATT
TACATCATTTCCTTCTTATTTGTTGAAAATGAGTTGTATTGCTAATCTTGATGTCTCTCGAAATGACATTGGACCCTCAGTGGTTTTAGA
TCCTACAGTGAAATGTCCAACTCTGAAACAGTTTAACCTGTCATATAACCAGCTGTCTTTTGTACCTGAGAACCTCACTGATGTGGTAGA
GAAACTGGAGCAGCTCATTTTAGAAGGAAATAAAATATCAGGGATATGCTCCCCCTTGAGACTGAAGGAACTGAAGATTTTAAACCTTAG
TAAGAACCACATTTCATCCCTATCAGAGAACTTTCTTGAGGCTTGTCCTAAAGTGGAGAGTTTCAGTGCCAGAATGAATTTTCTTGCTGC
TATGCCTTTCTTGCCTCCTTCTATGACAATCCTAAAATTATCTCAGAACAAATTTTCCTGTATTCCAGAAGCAATTTTAAATCTTCCACA
CTTGCGGTCTTTAGATATGAGCAGCAATGATATTCAGTACCTACCAGGTCCCGCACACTGGAAATCTTTGAACTTAAGGGAACTCTTATT
TAGCCATAATCAGATCAGCATCTTGGACTTGAGTGAAAAAGCATATTTATGGTCTAGAGTAGAGAAACTGCATCTTTCTCACAATAAACT
GAAAGAGATTCCTCCTGAGATTGGCTGTCTTGAAAATCTGACATCTCTGGATGTCAGTTACAACTTGGAACTAAGATCCTTTCCCAATGA
AATGGGGAAATTAAGCAAAATATGGGATCTTCCTTTGGATGAACTGCATCTTAACTTTGATTTTAAACATATAGGATGTAAAGCCAAAGA
CATCATAAGGTTTCTTCAACAGCGATTAAAAAAGGCTGTGCCTTATAACCGAATGAAACTTATGATTGTGGGAAATACTGGGAGTGGTAA
AACCACCTTATTGCAGCAATTAATGAAAACCAAGAAATCAGATCTTGGAATGCAAAGTGCCACAGTTGGCATAGATGTGAAAGACTGGCC
TATCCAAATAAGAGACAAAAGAAAGAGAGATCTCGTCCTAAATGTGTGGGATTTTGCAGGTCGTGAGGAATTCTATAGTACTCATCCCCA
TTTTATGACGCAGCGAGCATTGTACCTTGCTGTCTATGACCTCAGCAAGGGACAGGCTGAAGTTGATGCCATGAAGCCTTGGCTCTTCAA
TATAAAGGCTCGCGCTTCTTCTTCCCCTGTGATTCTCGTTGGCACACATTTGGATGTTTCTGATGAGAAGCAACGCAAAGCCTGCATGAG
TAAAATCACCAAGGAACTCCTGAATAAGCGAGGGTTCCCTGCCATACGAGATTACCACTTTGTGAATGCCACCGAGGAATCTGATGCTTT
GGCAAAACTTCGGAAAACCATCATAAACGAGAGCCTTAATTTCAAGATCCGAGATCAGCTTGTTGTTGGACAGCTGATTCCAGACTGCTA
TGTAGAACTTGAAAAAATCATTTTATCGGAGCGTAAAAATGTGCCAATTGAATTTCCCGTAATTGACCGGAAACGATTATTACAACTAGT
GAGAGAAAATCAGCTGCAGTTAGATGAAAATGAGCTTCCTCACGCAGTTCACTTTCTAAATGAATCAGGAGTCCTTCTTCATTTTCAAGA
CCCAGCACTGCAGTTAAGTGACTTGTACTTTGTGGAACCCAAGTGGCTTTGTAAAATCATGGCACAGATTTTGACAGTGAAAGTGGAAGG
TTGTCCAAAACACCCTAAGGGCATTATTTCGCGTAGAGATGTGGAAAAATTTCTTTCAAAAAAAAGGAAATTTCCAAAGAACTACATGTC
ACAGTATTTTAAGCTCCTAGAAAAATTCCAGATTGCTTTGCCAATAGGAGAAGAATATTTGCTGGTTCCAAGCAGTTTGTCTGACCACAG
GCCTGTGATAGAGCTTCCCCATTGTGAGAACTCTGAAATTATCATCCGACTATATGAAATGCCTTATTTTCCAATGGGATTTTGGTCAAG
ATTAATCAATCGATTACTTGAGATTTCACCTTACATGCTTTCAGGGAGAGAACGAGCACTTCGCCCAAACAGAATGTATTGGCGACAAGG
CATTTACTTAAATTGGTCTCCTGAAGCTTATTGTCTGGTAGGATCTGAAGTCTTAGACAATCATCCAGAGAGTTTCTTAAAAATTACAGT
TCCTTCTTGTAGAAAAGGCTGTATTCTTTTGGGCCAAGTTGTGGACCACATTGATTCTCTCATGGAAGAATGGTTTCCTGGGTTGCTGGA
GATTGATATTTGTGGTGAAGGAGAAACTCTGTTGAAGAAATGGGCATTATATAGTTTTAATGATGGTGAAGAACATCAAAAAATCTTACT
TGATGACTTGATGAAGAAAGCAGAGGAAGGAGATCTCTTAGTAAATCCAGATCAACCAAGGCTCACCATTCCAATATCTCAGATTGCCCC
TGACTTGATTTTGGCTGACCTGCCTAGAAATATTATGTTGAATAATGATGAGTTGGAATTTGAACAAGCTCCAGAGTTTCTCCTAGGTGA
TGGCAGTTTTGGATCAGTTTACCGAGCAGCCTATGAAGGAGAAGAAGTGGCTGTGAAGATTTTTAATAAACATACATCACTCAGGCTGTT
AAGACAAGAGCTTGTGGTGCTTTGCCACCTCCACCACCCCAGTTTGATATCTTTGCTGGCAGCTGGGATTCGTCCCCGGATGTTGGTGAT
GGAGTTAGCCTCCAAGGGTTCCTTGGATCGCCTGCTTCAGCAGGACAAAGCCAGCCTCACTAGAACCCTACAGCACAGGATTGCACTCCA
CGTAGCTGATGGTTTGAGATACCTCCACTCAGCCATGATTATATACCGAGACCTGAAACCCCACAATGTGCTGCTTTTCACACTGTATCC
CAATGCTGCCATCATTGCAAAGATTGCTGACTACGGCATTGCTCAGTACTGCTGTAGAATGGGGATAAAAACATCAGAGGGCACACCAGG
GTTTCGTGCACCTGAAGTTGCCAGAGGAAATGTCATTTATAACCAACAGGCTGATGTTTATTCATTTGGTTTACTACTCTATGACATTTT
GACAACTGGAGGTAGAATAGTAGAGGGTTTGAAGTTTCCAAATGAGTTTGATGAATTAGAAATACAAGGAAAATTACCTGATCCAGTTAA
AGAATATGGTTGTGCCCCATGGCCTATGGTTGAGAAATTAATTAAACAGTGTTTGAAAGAAAATCCTCAAGAAAGGCCTACTTCTGCCCA
GGTCTTTGACATTTTGAATTCAGCTGAATTAGTCTGTCTGACGAGACGCATTTTATTACCTAAAAACGTAATTGTTGAATGCATGGTTGC
TACACATCACAACAGCAGGAATGCAAGCATTTGGCTGGGCTGTGGGCACACCGACAGAGGACAGCTCTCATTTCTTGACTTAAATACTGA
AGGATACACTTCTGAGGAAGTTGCTGATAGTAGAATATTGTGCTTAGCCTTGGTGCATCTTCCTGTTGAAAAGGAAAGCTGGATTGTGTC
TGGGACACAGTCTGGTACTCTCCTGGTCATCAATACCGAAGATGGGAAAAAGAGACATACCCTAGAAAAGATGACTGATTCTGTCACTTG
TTTGTATTGCAATTCCTTTTCCAAGCAAAGCAAACAAAAAAATTTTCTTTTGGTTGGAACCGCTGATGGCAAGTTAGCAATTTTTGAAGA
TAAGACTGTTAAGCTTAAAGGAGCTGCTCCTTTGAAGATACTAAATATAGGAAATGTCAGTACTCCATTGATGTGTTTGAGTGAATCCAC
AAATTCAACGGAAAGAAATGTAATGTGGGGAGGATGTGGCACAAAGATTTTCTCCTTTTCTAATGATTTCACCATTCAGAAACTCATTGA
GACAAGAACAAGCCAACTGTTTTCTTATGCAGCTTTCAGTGATTCCAACATCATAACAGTGGTGGTAGACACTGCTCTCTATATTGCTAA
GCAAAATAGCCCTGTTGTGGAAGTGTGGGATAAGAAAACTGAAAAACTCTGTGGACTAATAGACTGCGTGCACTTTTTAAGGGAGGTAAT
GGTAAAAGAAAACAAGGAATCAAAACACAAAATGTCTTATTCTGGGAGAGTGAAAACCCTCTGCCTTCAGAAGAACACTGCTCTTTGGAT
AGGAACTGGAGGAGGCCATATTTTACTCCTGGATCTTTCAACTCGTCGACTTATACGTGTAATTTACAACTTTTGTAATTCGGTCAGAGT
CATGATGACAGCACAGCTAGGAAGCCTTAAAAATGTCATGCTGGTATTGGGCTACAACCGGAAAAATACTGAAGGTACACAAAAGCAGAA
AGAGATACAATCTTGCTTGACCGTTTGGGACATCAATCTTCCACATGAAGTGCAAAATTTAGAAAAACACATTGAAGTGAGAAAAGAATT
AGCTGAAAAAATGAGACGAACATCTGTTGAGTAAGAGAGAAATAGGAATTGTCTTTGGATAGGAAAATTATTCTCTCCTCTTGTAAATAT
TTATTTTAAAAATGTTCACATGGAAAGGGTACTCACATTTTTTGAAATAGCTCGTGTGTATGAAGGAATGTTATTATTTTTAATTTAAAT
ATATGTAAAAATACTTACCAGTAAATGTGTATTTTAAAGAACTATTTAAAACACAATGTTATATTTCTTATAAATACCAGTTACTTTCGT
TCATTAATTAATGAAAATAAATCTGTGAAGTACCTAATTTAAGTACTCATACTAAAATTTATAAGGCCGATAATTTTTTGTTTTCTTGTC
TGTAATGGAGGTAAACTTTATTTTAAATTCTGTGCTTAAGACAGGACTATTGCTTGTCGATTTTTCTAGAAATCTGCACGGTATAATGAA
AATATTAAGACAGTTTCCCATGTAATGTATTCCTTCTTAGATTGCATCGAAATGCACTATCATATATGCTTGTAAATATTCAAATGAATT
TGCACTAATAAAGTCCTTTGTTGGTATGTGAATTCTCTTTGTTGCTGTTGCAAACAGTGCATCTTACACAACTTCACTCAATTCAAAAGA
AAACTCCATTAAAAGTACTAATGAAAAAACATGACATACTGTCAAAGTCCTCATATCTAGGAAAGACACAGAAACTCTCTTTGTCACAGA
AACTCTCTGTGTCTTTCCTAGACATAATAGAGTTGTTTTTCAACTCTATGTTTGAATGTGGATACCCTGAATTTTGTATAATTAGTGTAA
ATACAGTGTTCAGTCCTTCAAGTGATATTTTTATTTTTTTATTCATACCACTAGCTACTTGTTTTCTAATCTGCTTCATTCTAATGCTTA
TATTCATCTTTTCCCTAAATTTGTGATGCTGCAGATCCTACATCATTCAGATAGAAACCTTTTTTTTTTTCAGAATTATAGAATTCCACA
GCTCCTACCAAGACCATGAGGATAAATATCTAACACTTTTCAGTTGCTGAAGGAGAAAGGAGCTTTAGTTATGATGGATAAAAATATCTG
CCACCCTAGGCTTCCAAATTATACTTAAATTGTTTACATAGCTTACCACAATAGGAGTATCAGGGCCAAATACCTATGTAATAATTTGAG
GTCATTTCTGCTTTAGGAAAAGTACTTTCGGTAAATTCTTTGGCCCTGACCAGTATTCATTATTTCAGATAATTCCCTGTGATAGGACAA
CTAGTACATTTAATATTCTCAGAACTTATGGCATTTTACTATGTGAAAACTTTAAATTTATTTATATTAAGGGTAATCAAATTCTTAAAG
ATGAAAGATTTTCTGTATTTTAAAGGAAGCTATGCTTTAACTTGTTATGTAATTAACAAAAAAATCATATATAATAGAGCTCTTTGTTCC
AGTGTTATCTCTTTCATTGTTACTTTGTATTTGCAATTTTTTTTACCAAAGACAAATTAAAAAAATGAATACCATATTTAAATGGAATAA

>30168_30168_1_FGD4-LRRK2_FGD4_chr12_32552893_ENST00000534526_LRRK2_chr12_40619357_ENST00000298910_length(amino acids)=2561AA_BP=84
MGMQATPPRGRSRLDGSGRSRGAAVEPGRMSDEGGSNFRRVAIRRKSNPSYLPPGVPRPWSRPASHLGRVGTAAFKGQVPSGATASKLFQ
GKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSG
KITLLILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPC
NNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLN
QDLEEKNENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQ
ASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALR
AILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY
PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQ
KDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT
ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSE
DVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSD
DSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNK
FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNL
SKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELL
FSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAK
DIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHP
HFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDA
LAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQ
DPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDH
RPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKIT
VPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIA
PDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLV
MELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTP
GFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSA
QVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIV
SGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSES
TNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREV
MVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQ

--------------------------------------------------------------
>30168_30168_2_FGD4-LRRK2_FGD4_chr12_32552893_ENST00000534526_LRRK2_chr12_40619357_ENST00000343742_length(transcript)=4899nt_BP=431nt
GGTAGCGGCTTTGAGTGAGTGCGGGAGCTGCAGATACCGAGACGCTGCGACTGCCGCAGGAGTCGCCGCAGCCAAACTCGCCGCGACGCC
GGGAGGGAGCGTACCGGGAAGGAGAGGGAGAGGAGGCACTCGCTGAGGAGACGCCGCAGTAGAGGGCGCCCCCGGAGTCGCGCCGAACCT
GGGCATGCAGGCGACGCCCCCCAGGGGCCGCTCGCGGCTGGACGGGAGCGGGAGGAGTCGGGGAGCGGCGGTCGAGCCCGGCAGGATGAG
CGACGAGGGCGGCTCCAACTTCAGGCGGGTGGCGATCCGGCGGAAGTCCAACCCCTCCTACCTGCCGCCCGGGGTGCCCCGGCCCTGGAG
CAGGCCCGCGTCGCACCTGGGACGTGTAGGGACCGCTGCCTTCAAGGGCCAGGTGCCCTCAGGAGCCACAGCCTCCAAGTTATTTCAAGG
CAAAAATATCCATGTGCCTCTGTTGATCGTCTTGGACTCCTATATGAGAGTCGCGAGTGTGCAGCAGGTGGGTTGGTCACTTCTGTGCAA
ATTAATAGAAGTCTGTCCAGGTACAATGCAAAGCTTAATGGGACCCCAGGATGTTGGAAATGATTGGGAAGTCCTTGGTGTTCACCAATT
GATTCTTAAAATGCTAACAGTTCATAATGCCAGTGTAAACTTGTCAGTGATTGGACTGAAGACCTTAGATCTCCTCCTAACTTCAGGTAA
AATCACCTTGCTGATATTGGATGAAGAAAGTGATATTTTCATGTTAATTTTTGATGCCATGCACTCATTTCCAGCCAATGATGAAGTCCA
GAAACTTGGATGCAAAGCTTTACATGTGCTGTTTGAGAGAGTCTCAGAGGAGCAACTGACTGAATTTGTTGAGAACAAAGATTATATGAT
ATTGTTAAGTGCGTTAACAAATTTTAAAGATGAAGAGGAAATTGTGCTTCATGTGCTGCATTGTTTACATTCCCTAGCGATTCCTTGCAA
TAATGTGGAAGTCCTCATGAGTGGCAATGTCAGGTGTTATAATATTGTGGTGGAAGCTATGAAAGCATTCCCTATGAGTGAAAGAATTCA
AGAAGTGAGTTGCTGTTTGCTCCATAGGCTTACATTAGGTAATTTTTTCAATATCCTGGTATTAAACGAAGTCCATGAGTTTGTGGTGAA
AGCTGTGCAGCAGTACCCAGAGAATGCAGCATTGCAGATCTCAGCGCTCAGCTGTTTGGCCCTCCTCACTGAGACTATTTTCTTAAATCA
AGATTTAGAGGAAAAGAATGAGAATCAAGAGAATGATGATGAGGGGGAAGAAGATAAATTGTTTTGGCTGGAAGCCTGTTACAAAGCATT
AACGTGGCATAGAAAGAACAAGCACGTGCAGGAGGCCGCATGCTGGGCACTAAATAATCTCCTTATGTACCAAAACAGTTTACATGAGAA
GATTGGAGATGAAGATGGCCATTTCCCAGCTCATAGGGAAGTGATGCTCTCCATGCTGATGCATTCTTCATCAAAGGAAGTTTTCCAGGC
ATCTGCGAATGCATTGTCAACTCTCTTAGAACAAAATGTTAATTTCAGAAAAATACTGTTATCAAAAGGAATACACCTGAATGTTTTGGA
GTTAATGCAGAAGCATATACATTCTCCTGAAGTGGCTGAAAGTGGCTGTAAAATGCTAAATCATCTTTTTGAAGGAAGCAACACTTCCCT
GGATATAATGGCAGCAGTGGTCCCCAAAATACTAACAGTTATGAAACGTCATGAGACATCATTACCAGTGCAGCTGGAGGCGCTTCGAGC
TATTTTACATTTTATAGTGCCTGGCATGCCAGAAGAATCCAGGGAGGATACAGAATTTCATCATAAGCTAAATATGGTTAAAAAACAGTG
TTTCAAGAATGATATTCACAAACTGGTCCTAGCAGCTTTGAACAGGTTCATTGGAAATCCTGGGATTCAGAAATGTGGATTAAAAGTAAT
TTCTTCTATTGTACATTTTCCTGATGCATTAGAGATGTTATCCCTGGAAGGTGCTATGGATTCAGTGCTTCACACACTGCAGATGTATCC
AGATGACCAAGAAATTCAGTGTCTGGGTTTAAGTCTTATAGGATACTTGATTACAAAGAAGAATGTGTTCATAGGAACTGGACATCTGCT
GGCAAAAATTCTGGTTTCCAGCTTATACCGATTTAAGGATGTTGCTGAAATACAGACTAAAGGATTTCAGACAATCTTAGCAATCCTCAA
ATTGTCAGCATCTTTTTCTAAGCTGCTGGTGCATCATTCATTTGACTTAGTAATATTCCATCAAATGTCTTCCAATATCATGGAACAAAA
GGATCAACAGTTTCTAAACCTCTGTTGCAAGTGTTTTGCAAAAGTAGCTATGGATGATTACTTAAAAAATGTGATGCTAGAGAGAGCGTG
TGATCAGAATAACAGCATCATGGTTGAATGCTTGCTTCTATTGGGAGCAGATGCCAATCAAGCAAAGGAGGGATCTTCTTTAATTTGTCA
GGTATGTGAGAAAGAGAGCAGTCCCAAATTGGTGGAACTCTTACTGAATAGTGGATCTCGTGAACAAGATGTACGAAAAGCGTTGACGAT
AAGCATTGGGAAAGGTGACAGCCAGATCATCAGCTTGCTCTTAAGGAGGCTGGCCCTGGATGTGGCCAACAATAGCATTTGCCTTGGAGG
ATTTTGTATAGGAAAAGTTGAACCTTCTTGGCTTGGTCCTTTATTTCCAGATAAGACTTCTAATTTAAGGAAACAAACAAATATAGCATC
TACACTAGCAAGAATGGTGATCAGATATCAGATGAAAAGTGCTGTGGAAGAAGGAACAGCCTCAGGCAGCGATGGAAATTTTTCTGAAGA
TGTGCTGTCTAAATTTGATGAATGGACCTTTATTCCTGACTCTTCTATGGACAGTGTGTTTGCTCAAAGTGATGACCTGGATAGTGAAGG
AAGTGAAGGCTCATTTCTTGTGAAAAAGAAATCTAATTCAATTAGTGTAGGAGAATTTTACCGAGATGCCGTATTACAGCGTTGCTCACC
AAATTTGCAAAGACATTCCAATTCCTTGGGGCCCATTTTTGATCATGAAGATTTACTGAAGCGAAAAAGAAAAATATTATCTTCAGATGA
TTCACTCAGGTCATCAAAACTTCAATCCCATATGAGGCATTCAGACAGCATTTCTTCTCTGGCTTCTGAGAGAGAATATATTACATCACT
AGACCTTTCAGCAAATGAACTAAGAGATATTGATGCCCTAAGCCAGAAATGCTGTATAAGTGTTCATTTGGAGCATCTTGAAAAGCTGGA
GCTTCACCAGAATGCACTCACGAGCTTTCCACAACAGCTATGTGAAACTCTGAAGAGTTTGACACATTTGGACTTGCACAGTAATAAATT
TACATCATTTCCTTCTTATTTGTTGAAAATGAGTTGTATTGCTAATCTTGATGTCTCTCGAAATGACATTGGACCCTCAGTGGTTTTAGA
TCCTACAGTGAAATGTCCAACTCTGAAACAGTTTAACCTGTCATATAACCAGCTGTCTTTTGTACCTGAGAACCTCACTGATGTGGTAGA
GAAACTGGAGCAGCTCATTTTAGAAGGAAATAAAATATCAGGGATATGCTCCCCCTTGAGACTGAAGGAACTGAAGATTTTAAACCTTAG
TAAGAACCACATTTCATCCCTATCAGAGAACTTTCTTGAGGCTTGTCCTAAAGTGGAGAGTTTCAGTGCCAGAATGAATTTTCTTGCTGC
TATGCCTTTCTTGCCTCCTTCTATGACAATCCTAAAATTATCTCAGAACAAATTTTCCTGTATTCCAGAAGCAATTTTAAATCTTCCACA
CTTGCGGTCTTTAGATATGAGCAGCAATGATATTCAGTACCTACCAGGTCCCGCACACTGGAAATCTTTGAACTTAAGGGAACTCTTATT
TAGCCATAATCAGATCAGCATCTTGGACTTGAGTGAAAAAGCATATTTATGGTCTAGAGTAGAGAAACTGCATCTTTCTCACAATAAACT
GAAAGAGGTAAGACGATTATTGCCACTTAAAAAATATACTTTATGATTTGCATCATTACAAATTATCATTTTAAGTGATATTTAGCTTCT
AAATACCAATTTCATGAAACTAGAAGCTTCCTGTTAACTATAAATTCCTGTCAACTATAAATCCAGATTTCCATTAAATTTAAAAATAAG
AACAGCTACTAATGATGTGTCACTTAATTTAATTTCCATTCTCACACCGACAATTTAAAAAAATCTACTTTTAAAAATAAGGTAGTAGCC
TTAATACTTCCACTAAACAATAAAACAATATGCTATACTTATCAGAACCTTTTAATCTGAAAGCTAAACAGCTAGATATAAATTTGTCTA
CCCAACATTTGTACAAAGTAAAAATTATTAGAATATTCATTTCAAATTATGTGTGATGTTATCATATAACATATTATAGATTAACTCAAA
TTATTCTTAACTGTTACTTAACTATGACAAAACAACTTAGAACGCTTTGCTAATACACAAGATAGTATAAGGATAAAAATTCTTTATAGT
ACTAGCTCATAAAGAGTGTTCTATGGAATAGTAGTGGATGTCATTTAATAACTATAAATTCAAAATAAGCATTGTAAATATCAATACCAT
TCAATTTTTTTTTGTTTTTTAAACAAGTTGTAAGCCTACCCTATGGTAAATGGATATGGTAACACAGCATAATTTCCTCAAAAAATTACT
TTTGTGATATACTTTTAAAGGATTATATGAATATATACATAATTATAGATGAATGTGATGCTGTGTGTCATTGTATCACCAAATCTCTGT

>30168_30168_2_FGD4-LRRK2_FGD4_chr12_32552893_ENST00000534526_LRRK2_chr12_40619357_ENST00000343742_length(amino acids)=1305AA_BP=84
MGMQATPPRGRSRLDGSGRSRGAAVEPGRMSDEGGSNFRRVAIRRKSNPSYLPPGVPRPWSRPASHLGRVGTAAFKGQVPSGATASKLFQ
GKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSG
KITLLILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPC
NNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLN
QDLEEKNENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQ
ASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALR
AILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY
PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQ
KDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT
ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSE
DVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSD
DSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNK
FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNL
SKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELL

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Fusion Gene PPI Analysis for FGD4-LRRK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FGD4-LRRK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FGD4-LRRK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source