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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FGD5-KPNA3 (FusionGDB2 ID:30179) |
Fusion Gene Summary for FGD5-KPNA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGD5-KPNA3 | Fusion gene ID: 30179 | Hgene | Tgene | Gene symbol | FGD5 | KPNA3 | Gene ID | 152273 | 3839 |
| Gene name | FYVE, RhoGEF and PH domain containing 5 | karyopherin subunit alpha 3 | |
| Synonyms | ZFYVE23 | IPOA4|SRP1|SRP1gamma|SRP4|hSRP1 | |
| Cytomap | 3p25.1 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FYVE, RhoGEF and PH domain-containing protein 5zinc finger FYVE domain-containing protein 23 | importin subunit alpha-4SRP1-gammaimportin alpha 4importin alpha Q2importin alpha-3importin subunit alpha-3karyopherin alpha 3 (importin alpha 4)qip2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q6ZNL6 | O00505 | |
| Ensembl transtripts involved in fusion gene | ENST00000476851, ENST00000285046, ENST00000543601, | ENST00000261667, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 11 X 9 X 5=495 |
| # samples | 4 | 11 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FGD5 [Title/Abstract] AND KPNA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FGD5(14952436)-KPNA3(50280508), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FGD5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KPNA3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRC | TCGA-CJ-4895-01A | FGD5 | chr3 | 14952436 | - | KPNA3 | chr13 | 50280508 | - |
| ChimerDB4 | KIRC | TCGA-CJ-4895-01A | FGD5 | chr3 | 14952436 | + | KPNA3 | chr13 | 50280508 | - |
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Fusion Gene ORF analysis for FGD5-KPNA3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000476851 | ENST00000261667 | FGD5 | chr3 | 14952436 | + | KPNA3 | chr13 | 50280508 | - |
| In-frame | ENST00000285046 | ENST00000261667 | FGD5 | chr3 | 14952436 | + | KPNA3 | chr13 | 50280508 | - |
| In-frame | ENST00000543601 | ENST00000261667 | FGD5 | chr3 | 14952436 | + | KPNA3 | chr13 | 50280508 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000285046 | FGD5 | chr3 | 14952436 | + | ENST00000261667 | KPNA3 | chr13 | 50280508 | - | 6538 | 3515 | 41 | 4048 | 1335 |
| ENST00000543601 | FGD5 | chr3 | 14952436 | + | ENST00000261667 | KPNA3 | chr13 | 50280508 | - | 6176 | 3153 | 12 | 3686 | 1224 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000285046 | ENST00000261667 | FGD5 | chr3 | 14952436 | + | KPNA3 | chr13 | 50280508 | - | 0.00026091 | 0.9997391 |
| ENST00000543601 | ENST00000261667 | FGD5 | chr3 | 14952436 | + | KPNA3 | chr13 | 50280508 | - | 0.000378946 | 0.99962103 |
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Fusion Genomic Features for FGD5-KPNA3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FGD5-KPNA3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:14952436/chr13:50280508) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGD5 | KPNA3 |
| FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. | FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FGD5 | chr3:14952436 | chr13:50280508 | ENST00000285046 | + | 11 | 20 | 58_323 | 1135 | 1463.0 | Compositional bias | Note=Glu-rich |
| Hgene | FGD5 | chr3:14952436 | chr13:50280508 | ENST00000285046 | + | 11 | 20 | 645_650 | 1135 | 1463.0 | Compositional bias | Note=Poly-Lys |
| Hgene | FGD5 | chr3:14952436 | chr13:50280508 | ENST00000285046 | + | 11 | 20 | 892_1084 | 1135 | 1463.0 | Domain | DH |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 361_400 | 344 | 522.0 | Repeat | Note=ARM 8 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 401_443 | 344 | 522.0 | Repeat | Note=ARM 9 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 447_485 | 344 | 522.0 | Repeat | Note=ARM 10%3B atypical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FGD5 | chr3:14952436 | chr13:50280508 | ENST00000285046 | + | 11 | 20 | 1113_1207 | 1135 | 1463.0 | Domain | PH 1 |
| Hgene | FGD5 | chr3:14952436 | chr13:50280508 | ENST00000285046 | + | 11 | 20 | 1363_1461 | 1135 | 1463.0 | Domain | PH 2 |
| Hgene | FGD5 | chr3:14952436 | chr13:50280508 | ENST00000285046 | + | 11 | 20 | 1242_1301 | 1135 | 1463.0 | Zinc finger | FYVE-type |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 2_58 | 344 | 522.0 | Domain | IBB | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 43_52 | 344 | 522.0 | Motif | Nuclear localization signal | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 137_229 | 344 | 522.0 | Region | NLS binding site (major) | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 306_394 | 344 | 522.0 | Region | NLS binding site (minor) | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 107_149 | 344 | 522.0 | Repeat | Note=ARM 2 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 150_194 | 344 | 522.0 | Repeat | Note=ARM 3 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 195_233 | 344 | 522.0 | Repeat | Note=ARM 4 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 234_278 | 344 | 522.0 | Repeat | Note=ARM 5 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 279_318 | 344 | 522.0 | Repeat | Note=ARM 6 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 319_360 | 344 | 522.0 | Repeat | Note=ARM 7 | |
| Tgene | KPNA3 | chr3:14952436 | chr13:50280508 | ENST00000261667 | 11 | 17 | 66_106 | 344 | 522.0 | Repeat | Note=ARM 1%3B truncated |
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Fusion Gene Sequence for FGD5-KPNA3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >30179_30179_1_FGD5-KPNA3_FGD5_chr3_14952436_ENST00000285046_KPNA3_chr13_50280508_ENST00000261667_length(transcript)=6538nt_BP=3515nt CAAAACCACCTGTCGCTCCCAAGCCAAAGACTACCAGTCCACTGACGCCAGTGACCGCGCCCAAATTCCCTTCCTCAGCCAGGCCCGAGA GTCTTCACAGTCCAAACTCCATGTTCAGGGGTCCGAAGCCCCCCATTGCCCCCAAGCCCAGGCTGACTGCCCCAAACGAGTGGAGAGCCA GTGTGTACCTGAATGACAGCTTGAACAAATGCAGCAACGGGCGGCTGCCCTGTGTAGACAGGGGGCTTGATGAGGGGCCCCGGTCCATCC CAAAGTGCTCTGAGTCGGAGACCGACGAGGATTACATCGTGGTCCCCAGGGTTCCGCTGAGGGAGGATGAACCCAAGGACGAGGGCAGTG TGGGGAACAAAGCCCTGGTGTCTCCCGAGTCCTCTGCGGAAGAGGAAGAGGAGCGTGAAGAGGGAGGCGAGGCATGTGGCCTGGAGGGTA CAGGAGCTGGTGAGGATTCAGTGGCCCCTGCTGCTCCGGGTGCAGGAGCGCTGAGCAGGGAGGGTGAGGAAGGCACAGACCTTGCTCTTG AGGATGAAGGGGAGGGCTGCGCTGATGAGCCAGGGACACTGGAGCAGGTGTCCAGAAGTGAGGAGGAAGAGAAGCTAGTGCAGCCACACA GGGAGTGCAGCCTGGAGGACAGTGGGCCTTGGGCTGGAGAGGGGGTCTTCCAGAGCGACCTCCTCCTGCCTCACATCCATGGAGAGGACC AGGAGCCCCCCGACACCCCCGGGGAGGCAGAGGAGGATGATGAGGAAGGCTGTGCCAGCACAGACCCAGCAGGGGCAGATGAGGGTTCGG GTCCTGACAGGCCCACGGAGGACATGGGACAGGATGCTGAGGACACCAGTGAGGAGCCCCCTGAGAAGGAGGAGCTGGCCGGGGTCCAGG AGGCAGAGACAGCCACAGACTGCCCTGAAGTTCTTGAGGAGGGATGTGAAGAGGCCACGGGTGTCACAGGTGGGGAACAGGTTGACCTCA GTGAACCACCTGACCACGAGAAGAAAACCAACCAAGAAGTGGCAGCCGCCACCCTGGAGGACCATGCACAGGATGAGTCCGCCGAGGAGA GCTGCCAGATTGTCCCTTTTGAGAATGACTGCATGGAGGACTTCGTGACTTCCCTCACAGGAAGCCCCTATGAGTTCTTCCCAACTGAGA GCACCTCTTTTTGCAGCGAGAGCTGTTCTCCTCTTTCTGAATCAGCGAAAGGTTTAGAATCAGAGCAGGCACCAAAGCTGGGGCTGCGTG CGGAGGAGAACCCCATGGTGGGGGCTTTGTGTGGCCAGTGTGGCTCCCTACAGGGTGGAGCGGCCGAGGGTCCCGCAGCCCCTGATGTGG TGGTCGTGCTGGAGGAGGAGGCCTTGGATGATGCACTGGCCAACCCCTATGTGATGGGAGTGGGCCTGCCCGGTCAGGCGGCCCCTGGAG AAGGAGGGCAGGCTGCATCGGACGCCCTGGGTGGTTATGGCTCGAAAGAAGAATTGAACTGTGAGGCAGAGGGTGGCCTGGTTCCCGCGG ACAGGAAGAACACCAGCACGAGGGTCCGGCCCCACTCTGGGAAGGTGGCCGGCTATGTCCCAGAAACCGTCCCTGAAGAAACCGGACCTG AGGCGGGCTCGTCAGCCCCTGGCATTGGAGGTGCCGCAGAGGAGGTGGGAAAGACGCTTTTGTCATTGGAGGGGAAGCCCTTGGAAGCCA GCAGGGCCTTGCCAGCAAAGCCCAGGGCCTTTACTTTATACCCTCGGTCGTTCTCCGTGGAAGGCCGAGAGATTCCAGTGTCCGTGTACC AGGAGCCTGAGGGGTCAGGGTTGGATGACCACAGGATAAAGAGGAAAGAGGACAATCTCTCTCTGTCGTGTGTAATTGGCTCCTCTGGGA GTTTCTCCCAGAGAAACCACCTTCCGTCCAGCGGCACCTCCACGCCTTCTTCCATGGTCGACATCCCACCTCCTTTCGACCTGGCCTGCA TCACCAAGAAGCCCATCACAAAGAGCTCTCCCTCACTCCTGATCGAGAGCGACTCCCCGGACAAGTACAAGAAGAAGAAGTCATCCTTTA AGCGCTTCCTGGCACTGACGTTTAAGAAGAAGACGGAGAACAAATTGCATGTGGATGTGAACGTGTCTTCCTCTAGGTCCTCTTCAGAGT CCAGCTACCACGGGCCTTCCAGGATTCTGGAAGTTGACCGGAGAAGCCTCAGCAACTCCCCTCAGCTTAAGTCTCGGACTGGGAAGCTCC GGGCTTCTGAATCCCCCTCCTCCCTCATCTTTTATAGAGATGGCAAGAGGAAAGGTGTCCCCTTCAGCAGGACGGTGTCCAGAGTGGAGT CCTTTGAAGACCGCTCCCGGCCGCCCTTCCTGCCCTTGCCACTGACCAAGCCACGGTCCATCTCCTTCCCCAGCGCTGACACTTCAGACT ATGAGAACATTCCAGCCATGAACTCGGACTATGAGAATATCCAGATTCCACCCCGGAGACCTGCCAGGGCTGGCGCGTTCACGAAGCTGT TTGAAGATCAGAGCAGAGCCCTGTCCACAGCAAACGAAAATGATGGCTACGTGGACATGAGCAGCTTCAACGCCTTTGAGAGCAAACAGC AGAGTGCAGACCAGGACGCAGAAAGCGCCTACACAGAGCCCTACAAAGTCTGTCCCATCTCGTCGGCAGCCCCCAAAGAGGACCTTACGT CGGATGAAGAGCAGAGAAGCTCGGAGGAGGAGGACAGTGCTTCAAGAGACCCCAGTGTCACCCACAAGGTGGAAGGACAGTCCAGAGCCC TTGTCATCGCACAGGAACTGCTATCTTCAGAGAAAGCATACGTGGAGATGCTCCAGCACTTAAATCTGGATTTCCATGGAGCTGTCATGA GGGCCTTGGATGACATGGACCATGAAGGCAGAGACACATTGGCCCGGGAGGAGCTGAGGCAGGGCCTGAGTGAACTCCCAGCCATCCACG ACCTTCATCAAGGCATCCTGGAGGAGCTGGAGGAAAGGCTGTCAAATTGGGAGAGCCAGCAGAAGGTAGCTGACGTCTTCCTGGCCCGGG AGCAGGGGTTTGATCACCACGCCACTCACATCCTGCAGTTCGACAGGTACCTAGGTCTGCTCAGTGAGAATTGCCTCCACTCTCCCCGGC TGGCAGCTGCTGTCCGTGAATTTGAGCAGAGTGTACAAGGAGGCAGCCAGACTGCGAAGCATCGGCTGCTGCGGGTGGTTCAACGCCTCT TCCAGTACCAAGTGCTCCTCACAGACTATTTAAACAACCTTTGTCCGGACTCCGCCGAGTACGACAACACACAGGGTGCACTGAGCCTCA TCTCCAAAGTCACAGACCGTGCCAACGACAGCATGGAGCAAGGGGAAAACCTGCAGAAGCTGGTCCACATTGAGCACAGCGTCCGGGGCC AAGGGGATCTCCTCCAGCCAGGAAGGGAGTTTCTGAAGGAAGGGACGCTGATGAAAGTAACAGGGAAAAACAGACGGCCCCGGCACCTAT TTCTGGAAGCAGTGTGGTTCCTTTCCAACATAACAGCAGGCAACCAGCAACAAGTTCAAGCTGTAATAGATGCTGGATTAATTCCTATGA TAATTCATCAGCTTGCTAAGGGGGACTTTGGAACACAAAAAGAAGCTGCTTGGGCAATCAGCAACTTAACAATAAGTGGCAGAAAAGATC AGGTTGAGTACCTTGTACAGCAGAATGTAATACCACCGTTCTGTAATTTACTGTCAGTGAAAGATTCTCAAGTGGTTCAGGTGGTTCTAG ATGGTCTAAAAAACATTCTGATAATGGCCGGTGATGAAGCAAGCACAATAGCTGAAATAATAGAGGAATGTGGAGGTTTGGAGAAAATTG AAGTTTTACAGCAACATGAAAATGAAGACATATATAAATTAGCATTTGAAATCATAGATCAGTATTTCTCTGGTGATGATATTGATGAAG ATCCCTGCCTCATTCCTGAAGCAACACAAGGAGGTACCTACAATTTTGATCCAACAGCCAACCTTCAAACAAAAGAATTTAATTTTTAAA TTCAGTTGAGTGCAGCATCTTTCCCACATTCAATATGAAGCACCACCAGATGGCTACCAAATGATAAGAACAACAGCAACAAAAGGCTCC AAAACACACATGCCTCTTTGTTTTGATGCTTCTAAAGCAAGCCATGTCTCAGTCACTTTGCAGTTGCCAAAAGTCACTATCACATGGACT GTAAATGCATATGCATGATTTCCTAAACTGTTTTAGAACTCTCCTTAACAATCTCAACTACCCTATTTTTCCCTGTTCCCTGGTGCCACA GGCTGACAACTGCAGTCTCCAGTTTAGAATAAATATTCCATAGTGGTGACATGTCAGCTGCCCACTGATACTCCTTTGGAAAATGGTGCG CTGTGGATCAAGACACTTTGGTATGATGCATATACAAGTTGGAAGACTAAAGAGGTGCAGTGTGATCTGAGCCTCCATCATTGTCCTCCA CAAACATATTTTCATATTCTTTATGTGGAAGAATAGATTTTAAAGTACAAGCCAAATGATTTTCATTGGTGGAACTGACACAAAAAAAGT AACTTAAAAACAAGAAACTTGGTTATTGAATAAACAGATAAGTTTAAAAAAAAAAAAAAACTACTTCATCTACCAGTAATTGATGTGTTT ATTATCTGCCTCAGAAGCCAGGGTTGGAGGAAGAACTTTAGATATGGATATTAATGCTTTTGCCATTATACCTAATTTTTGAGAACAGCA AGCCCTATTTGACCACTCTCTTCAGCCTGTGTGTTCCTGCTGTTTTGAAGTAATCAAATGCTGTGCATGGTATTTTACCTGAGCTGCAAC CTGTTATGGACTTGAACTTCTGTTTAAGTTGAAAGCAAGAGTCCCTGAGTATAAAGGAAAAACAGCAAAACAAAAAGCAAACAAAAAAAA ACTGCAAAAGTCTAAAATACCCATTGGTGATGTTTTTTAAAAAAATCTTGCTTTCAGCTTTCAGGAGTTAATATTCTTTGTTTTAATTTG ATAATTGGATATGGTTGATTTATATTGGGTTTAAACTGTGGAGCTTTCATGTTTACTGTAATTTAGTCTTAAAATATTTTTTACTTAGTA ACCAGTGCTTTTGATAATGTGGTTGGCAACAAACCAGCAACTATTTAGAAGTGTCATAAGAGTTCATTCTTTGAGTATTGGGAAAGTTAA TTCAGATCCTACTCAAAAAGCATCTTCACATATTAAAAGATTCAGACAGGGATCTGTGTAGAGGAGTAATTTGCAGTTATTTAACATAAA CCTGATTTGCAGTGATCTCTAAGTAATTCTGCAAAATCCGGTATTACTATGTCAAGTTATTGCTTTTGGTAAATTGTCTGACCCAGTTAT TAATGAAAGAATATGGATTTAAAAATTTTTAAACTAAATAATTTGTGCTGTCACAGAAATGGTATTGTTGCTCTTGTTTACTGGGTATAA TTTCCCAATGCATTGATGTGAAGGGATAGAAAATCTAAACTAATTTAGTTATCCATTGGGGGGTGTATTTACTGTGATGAAGATGAGACA GATGCCATCAGAGCTTTGTGAATCAGCTGGGGTGTTTTCACTGATAAACAACACATAGCAGGTGTGCATTCATTACAAATATATGTATCT GCCAAGGTGGAGCCACTTTAAAGAGTGAGTTTTGTCTTGTATCTAAAGTGGATACAAGCGTATGTTTAAACTGCAAGATTTTTACTTGCT AGAGAATCTGTTTTAATATAGTGGTTTGGCCTCTGATTATTTATAGGTTTTATAAATTTTAGAATCAATTTCTCTTTAAGGTGGCTCAGA TTTTTCAACTCTTGTGCACATAAAATTGAGTTGAAGTTCATTGTGCCTTTTTTTCTTTATCCAAATTTTGAGTTAAAGCTTCATATGGTA ACTGCATCCTGTTCGGACACTATAGTCTAAATTTTTGAAACTGTGTGGTGTTCGCTAAAAGTAGGAATAACAACGTAAAAGCTAATTAAG GTCACAAACTTCGGTGAAACCCTTAAAAGTCCAAATCTTCTTGATATTGTGAACCGTACCCCTTCCAGTTTAGTTTCTTCTGGACTTTCC TTACTTAACTGACAGTTACCTTTTAAAATTTGCACACATTATGATTAAAATTGGGCCTCTACTGTGATGATTCCTATTTCCTCTCATGTT TTAAAGTGCAAACTAACATTTAAGTGAACATTAGCATCAAGTAGTGCAGACACTTGTATGCATTTCCTTGATTCAATTTGTGACCTTACC AGTTTTGAATTGGAATTGCACCATTTCGTAGATAAAGGAAACTAAGTATATTGCTGCACTTTTAAGTTTTCAAAACAGTGTTTAAAAATT GCATTGTTATTTTTTTTTAAACTCAGTTTAAAAAGACTAAAACGTTCTTTCAAAAGAGGCATCTAAATGTGTTCCTAATTTTGTATATGG >30179_30179_1_FGD5-KPNA3_FGD5_chr3_14952436_ENST00000285046_KPNA3_chr13_50280508_ENST00000261667_length(amino acids)=1335AA_BP=1158 MTPVTAPKFPSSARPESLHSPNSMFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESETDEDYIV VPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTL EQVSRSEEEEKLVQPHRECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAE DTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMED FVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALA NPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAE EVGKTLLSLEGKPLEASRALPAKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNHLPSSGTS TPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDR RSLSNSPQLKSRTGKLRASESPSSLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAMNSDYENI QIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSA SRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERL SNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNL CPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLEAVWFLSNITAG NQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEA -------------------------------------------------------------- >30179_30179_2_FGD5-KPNA3_FGD5_chr3_14952436_ENST00000543601_KPNA3_chr13_50280508_ENST00000261667_length(transcript)=6176nt_BP=3153nt GGGAACAAAGCCCTGGTGTCTCCCGAGTCCTCTGCGGAAGAGGAAGAGGAGCGTGAAGAGGGAGGCGAGGCATGTGGCCTGGAGGGTACA GGAGCTGGTGAGGATTCAGTGGCCCCTGCTGCTCCGGGTGCAGGAGCGCTGAGCAGGGAGGGTGAGGAAGGCACAGACCTTGCTCTTGAG GATGAAGGGGAGGGCTGCGCTGATGAGCCAGGGACACTGGAGCAGGTGTCCAGAAGTGAGGAGGAAGAGAAGCTAGTGCAGCCACACAGG GAGTGCAGCCTGGAGGACAGTGGGCCTTGGGCTGGAGAGGGGGTCTTCCAGAGCGACCTCCTCCTGCCTCACATCCATGGAGAGGACCAG GAGCCCCCCGACACCCCCGGGGAGGCAGAGGAGGATGATGAGGAAGGCTGTGCCAGCACAGACCCAGCAGGGGCAGATGAGGGTTCGGGT CCTGACAGGCCCACGGAGGACATGGGACAGGATGCTGAGGACACCAGTGAGGAGCCCCCTGAGAAGGAGGAGCTGGCCGGGGTCCAGGAG GCAGAGACAGCCACAGACTGCCCTGAAGTTCTTGAGGAGGGATGTGAAGAGGCCACGGGTGTCACAGGTGGGGAACAGGTTGACCTCAGT GAACCACCTGACCACGAGAAGAAAACCAACCAAGAAGTGGCAGCCGCCACCCTGGAGGACCATGCACAGGATGAGTCCGCCGAGGAGAGC TGCCAGATTGTCCCTTTTGAGAATGACTGCATGGAGGACTTCGTGACTTCCCTCACAGGAAGCCCCTATGAGTTCTTCCCAACTGAGAGC ACCTCTTTTTGCAGCGAGAGCTGTTCTCCTCTTTCTGAATCAGCGAAAGGTTTAGAATCAGAGCAGGCACCAAAGCTGGGGCTGCGTGCG GAGGAGAACCCCATGGTGGGGGCTTTGTGTGGCCAGTGTGGCTCCCTACAGGGTGGAGCGGCCGAGGGTCCCGCAGCCCCTGATGTGGTG GTCGTGCTGGAGGAGGAGGCCTTGGATGATGCACTGGCCAACCCCTATGTGATGGGAGTGGGCCTGCCCGGTCAGGCGGCCCCTGGAGAA GGAGGGCAGGCTGCATCGGACGCCCTGGGTGGTTATGGCTCGAAAGAAGAATTGAACTGTGAGGCAGAGGGTGGCCTGGTTCCCGCGGAC AGGAAGAACACCAGCACGAGGGTCCGGCCCCACTCTGGGAAGGTGGCCGGCTATGTCCCAGAAACCGTCCCTGAAGAAACCGGACCTGAG GCGGGCTCGTCAGCCCCTGGCATTGGAGGTGCCGCAGAGGAGGTGGGAAAGACGCTTTTGTCATTGGAGGGGAAGCCCTTGGAAGCCAGC AGGGCCTTGCCAGCAAAGCCCAGGGCCTTTACTTTATACCCTCGGTCGTTCTCCGTGGAAGGCCGAGAGATTCCAGTGTCCGTGTACCAG GAGCCTGAGGGGTCAGGGTTGGATGACCACAGGATAAAGAGGAAAGAGGACAATCTCTCTCTGTCGTGTGTAATTGGCTCCTCTGGGAGT TTCTCCCAGAGAAACCACCTTCCGTCCAGCGGCACCTCCACGCCTTCTTCCATGGTCGACATCCCACCTCCTTTCGACCTGGCCTGCATC ACCAAGAAGCCCATCACAAAGAGCTCTCCCTCACTCCTGATCGAGAGCGACTCCCCGGACAAGTACAAGAAGAAGAAGTCATCCTTTAAG CGCTTCCTGGCACTGACGTTTAAGAAGAAGACGGAGAACAAATTGCATGTGGATGTGAACGTGTCTTCCTCTAGGTCCTCTTCAGAGTCC AGCTACCACGGGCCTTCCAGGATTCTGGAAGTTGACCGGAGAAGCCTCAGCAACTCCCCTCAGCTTAAGTCTCGGACTGGGAAGCTCCGG GCTTCTGAATCCCCCTCCTCCCTCATCTTTTATAGAGATGGCAAGAGGAAAGGTGTCCCCTTCAGCAGGACGGTGTCCAGAGTGGAGTCC TTTGAAGACCGCTCCCGGCCGCCCTTCCTGCCCTTGCCACTGACCAAGCCACGGTCCATCTCCTTCCCCAGCGCTGACACTTCAGACTAT GAGAACATTCCAGCCATGAACTCGGACTATGAGAATATCCAGATTCCACCCCGGAGACCTGCCAGGGCTGGCGCGTTCACGAAGCTGTTT GAAGATCAGAGCAGAGCCCTGTCCACAGCAAACGAAAATGATGGCTACGTGGACATGAGCAGCTTCAACGCCTTTGAGAGCAAACAGCAG AGTGCAGACCAGGACGCAGAAAGCGCCTACACAGAGCCCTACAAAGTCTGTCCCATCTCGTCGGCAGCCCCCAAAGAGGACCTTACGTCG GATGAAGAGCAGAGAAGCTCGGAGGAGGAGGACAGTGCTTCAAGAGACCCCAGTGTCACCCACAAGGTGGAAGGACAGTCCAGAGCCCTT GTCATCGCACAGGAACTGCTATCTTCAGAGAAAGCATACGTGGAGATGCTCCAGCACTTAAATCTGGATTTCCATGGAGCTGTCATGAGG GCCTTGGATGACATGGACCATGAAGGCAGAGACACATTGGCCCGGGAGGAGCTGAGGCAGGGCCTGAGTGAACTCCCAGCCATCCACGAC CTTCATCAAGGCATCCTGGAGGAGCTGGAGGAAAGGCTGTCAAATTGGGAGAGCCAGCAGAAGGTAGCTGACGTCTTCCTGGCCCGGGAG CAGGGGTTTGATCACCACGCCACTCACATCCTGCAGTTCGACAGGTACCTAGGTCTGCTCAGTGAGAATTGCCTCCACTCTCCCCGGCTG GCAGCTGCTGTCCGTGAATTTGAGCAGAGTGTACAAGGAGGCAGCCAGACTGCGAAGCATCGGCTGCTGCGGGTGGTTCAACGCCTCTTC CAGTACCAAGTGCTCCTCACAGACTATTTAAACAACCTTTGTCCGGACTCCGCCGAGTACGACAACACACAGGGTGCACTGAGCCTCATC TCCAAAGTCACAGACCGTGCCAACGACAGCATGGAGCAAGGGGAAAACCTGCAGAAGCTGGTCCACATTGAGCACAGCGTCCGGGGCCAA GGGGATCTCCTCCAGCCAGGAAGGGAGTTTCTGAAGGAAGGGACGCTGATGAAAGTAACAGGGAAAAACAGACGGCCCCGGCACCTATTT CTGGAAGCAGTGTGGTTCCTTTCCAACATAACAGCAGGCAACCAGCAACAAGTTCAAGCTGTAATAGATGCTGGATTAATTCCTATGATA ATTCATCAGCTTGCTAAGGGGGACTTTGGAACACAAAAAGAAGCTGCTTGGGCAATCAGCAACTTAACAATAAGTGGCAGAAAAGATCAG GTTGAGTACCTTGTACAGCAGAATGTAATACCACCGTTCTGTAATTTACTGTCAGTGAAAGATTCTCAAGTGGTTCAGGTGGTTCTAGAT GGTCTAAAAAACATTCTGATAATGGCCGGTGATGAAGCAAGCACAATAGCTGAAATAATAGAGGAATGTGGAGGTTTGGAGAAAATTGAA GTTTTACAGCAACATGAAAATGAAGACATATATAAATTAGCATTTGAAATCATAGATCAGTATTTCTCTGGTGATGATATTGATGAAGAT CCCTGCCTCATTCCTGAAGCAACACAAGGAGGTACCTACAATTTTGATCCAACAGCCAACCTTCAAACAAAAGAATTTAATTTTTAAATT CAGTTGAGTGCAGCATCTTTCCCACATTCAATATGAAGCACCACCAGATGGCTACCAAATGATAAGAACAACAGCAACAAAAGGCTCCAA AACACACATGCCTCTTTGTTTTGATGCTTCTAAAGCAAGCCATGTCTCAGTCACTTTGCAGTTGCCAAAAGTCACTATCACATGGACTGT AAATGCATATGCATGATTTCCTAAACTGTTTTAGAACTCTCCTTAACAATCTCAACTACCCTATTTTTCCCTGTTCCCTGGTGCCACAGG CTGACAACTGCAGTCTCCAGTTTAGAATAAATATTCCATAGTGGTGACATGTCAGCTGCCCACTGATACTCCTTTGGAAAATGGTGCGCT GTGGATCAAGACACTTTGGTATGATGCATATACAAGTTGGAAGACTAAAGAGGTGCAGTGTGATCTGAGCCTCCATCATTGTCCTCCACA AACATATTTTCATATTCTTTATGTGGAAGAATAGATTTTAAAGTACAAGCCAAATGATTTTCATTGGTGGAACTGACACAAAAAAAGTAA CTTAAAAACAAGAAACTTGGTTATTGAATAAACAGATAAGTTTAAAAAAAAAAAAAAACTACTTCATCTACCAGTAATTGATGTGTTTAT TATCTGCCTCAGAAGCCAGGGTTGGAGGAAGAACTTTAGATATGGATATTAATGCTTTTGCCATTATACCTAATTTTTGAGAACAGCAAG CCCTATTTGACCACTCTCTTCAGCCTGTGTGTTCCTGCTGTTTTGAAGTAATCAAATGCTGTGCATGGTATTTTACCTGAGCTGCAACCT GTTATGGACTTGAACTTCTGTTTAAGTTGAAAGCAAGAGTCCCTGAGTATAAAGGAAAAACAGCAAAACAAAAAGCAAACAAAAAAAAAC TGCAAAAGTCTAAAATACCCATTGGTGATGTTTTTTAAAAAAATCTTGCTTTCAGCTTTCAGGAGTTAATATTCTTTGTTTTAATTTGAT AATTGGATATGGTTGATTTATATTGGGTTTAAACTGTGGAGCTTTCATGTTTACTGTAATTTAGTCTTAAAATATTTTTTACTTAGTAAC CAGTGCTTTTGATAATGTGGTTGGCAACAAACCAGCAACTATTTAGAAGTGTCATAAGAGTTCATTCTTTGAGTATTGGGAAAGTTAATT CAGATCCTACTCAAAAAGCATCTTCACATATTAAAAGATTCAGACAGGGATCTGTGTAGAGGAGTAATTTGCAGTTATTTAACATAAACC TGATTTGCAGTGATCTCTAAGTAATTCTGCAAAATCCGGTATTACTATGTCAAGTTATTGCTTTTGGTAAATTGTCTGACCCAGTTATTA ATGAAAGAATATGGATTTAAAAATTTTTAAACTAAATAATTTGTGCTGTCACAGAAATGGTATTGTTGCTCTTGTTTACTGGGTATAATT TCCCAATGCATTGATGTGAAGGGATAGAAAATCTAAACTAATTTAGTTATCCATTGGGGGGTGTATTTACTGTGATGAAGATGAGACAGA TGCCATCAGAGCTTTGTGAATCAGCTGGGGTGTTTTCACTGATAAACAACACATAGCAGGTGTGCATTCATTACAAATATATGTATCTGC CAAGGTGGAGCCACTTTAAAGAGTGAGTTTTGTCTTGTATCTAAAGTGGATACAAGCGTATGTTTAAACTGCAAGATTTTTACTTGCTAG AGAATCTGTTTTAATATAGTGGTTTGGCCTCTGATTATTTATAGGTTTTATAAATTTTAGAATCAATTTCTCTTTAAGGTGGCTCAGATT TTTCAACTCTTGTGCACATAAAATTGAGTTGAAGTTCATTGTGCCTTTTTTTCTTTATCCAAATTTTGAGTTAAAGCTTCATATGGTAAC TGCATCCTGTTCGGACACTATAGTCTAAATTTTTGAAACTGTGTGGTGTTCGCTAAAAGTAGGAATAACAACGTAAAAGCTAATTAAGGT CACAAACTTCGGTGAAACCCTTAAAAGTCCAAATCTTCTTGATATTGTGAACCGTACCCCTTCCAGTTTAGTTTCTTCTGGACTTTCCTT ACTTAACTGACAGTTACCTTTTAAAATTTGCACACATTATGATTAAAATTGGGCCTCTACTGTGATGATTCCTATTTCCTCTCATGTTTT AAAGTGCAAACTAACATTTAAGTGAACATTAGCATCAAGTAGTGCAGACACTTGTATGCATTTCCTTGATTCAATTTGTGACCTTACCAG TTTTGAATTGGAATTGCACCATTTCGTAGATAAAGGAAACTAAGTATATTGCTGCACTTTTAAGTTTTCAAAACAGTGTTTAAAAATTGC ATTGTTATTTTTTTTTAAACTCAGTTTAAAAAGACTAAAACGTTCTTTCAAAAGAGGCATCTAAATGTGTTCCTAATTTTGTATATGGGC >30179_30179_2_FGD5-KPNA3_FGD5_chr3_14952436_ENST00000543601_KPNA3_chr13_50280508_ENST00000261667_length(amino acids)=1224AA_BP=1047 MVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSL EDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETA TDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFC SESCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALANPYVMGVGLPGQAAPGEGGQA ASDALGGYGSKEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALP AKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNHLPSSGTSTPSSMVDIPPPFDLACITKKP ITKSSPSLLIESDSPDKYKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASES PSSLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAGAFTKLFEDQS RALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQ ELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFD HHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVT DRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQL AKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FGD5-KPNA3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FGD5-KPNA3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FGD5-KPNA3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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