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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGD5-SLC6A6 (FusionGDB2 ID:30181)

Fusion Gene Summary for FGD5-SLC6A6

check button Fusion gene summary
Fusion gene informationFusion gene name: FGD5-SLC6A6
Fusion gene ID: 30181
HgeneTgene
Gene symbol

FGD5

SLC6A6

Gene ID

152273

6533

Gene nameFYVE, RhoGEF and PH domain containing 5solute carrier family 6 member 6
SynonymsZFYVE23TAUT
Cytomap

3p25.1

3p25.1

Type of geneprotein-codingprotein-coding
DescriptionFYVE, RhoGEF and PH domain-containing protein 5zinc finger FYVE domain-containing protein 23sodium- and chloride-dependent taurine transportersolute carrier family 6 (neurotransmitter transporter, taurine), member 6
Modification date2020031320200327
UniProtAcc

Q6ZNL6

.
Ensembl transtripts involved in fusion geneENST00000285046, ENST00000543601, 
ENST00000476851, 		ENST00000416216, 
ENST00000484191, ENST00000360861, 
ENST00000454876, 
Fusion gene scores* DoF score4 X 4 X 4=643 X 3 X 2=18
# samples 43
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FGD5 [Title/Abstract] AND SLC6A6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGD5(14863103)-SLC6A6(14526375), # samples:3
SLC6A6(14457961)-FGD5(14905635), # samples:2
Anticipated loss of major functional domain due to fusion event.FGD5-SLC6A6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FGD5-SLC6A6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FGD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC6A6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3LS-01AFGD5chr3

14863103

-SLC6A6chr3

14526375

+
ChimerDB4SARCTCGA-DX-A3LS-01AFGD5chr3

14863103

+SLC6A6chr3

14526375

+


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Fusion Gene ORF analysis for FGD5-SLC6A6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000285046ENST00000416216FGD5chr3

14863103

+SLC6A6chr3

14526375

+
5CDS-intronENST00000285046ENST00000484191FGD5chr3

14863103

+SLC6A6chr3

14526375

+
5CDS-intronENST00000543601ENST00000416216FGD5chr3

14863103

+SLC6A6chr3

14526375

+
5CDS-intronENST00000543601ENST00000484191FGD5chr3

14863103

+SLC6A6chr3

14526375

+
Frame-shiftENST00000285046ENST00000360861FGD5chr3

14863103

+SLC6A6chr3

14526375

+
Frame-shiftENST00000543601ENST00000360861FGD5chr3

14863103

+SLC6A6chr3

14526375

+
In-frameENST00000285046ENST00000454876FGD5chr3

14863103

+SLC6A6chr3

14526375

+
In-frameENST00000543601ENST00000454876FGD5chr3

14863103

+SLC6A6chr3

14526375

+
intron-3CDSENST00000476851ENST00000360861FGD5chr3

14863103

+SLC6A6chr3

14526375

+
intron-3CDSENST00000476851ENST00000454876FGD5chr3

14863103

+SLC6A6chr3

14526375

+
intron-intronENST00000476851ENST00000416216FGD5chr3

14863103

+SLC6A6chr3

14526375

+
intron-intronENST00000476851ENST00000484191FGD5chr3

14863103

+SLC6A6chr3

14526375

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285046FGD5chr314863103+ENST00000454876SLC6A6chr314526375+71182635412653870
ENST00000543601FGD5chr314863103+ENST00000454876SLC6A6chr314526375+67562273122291759

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285046ENST00000454876FGD5chr314863103+SLC6A6chr314526375+0.0011900380.99880993
ENST00000543601ENST00000454876FGD5chr314863103+SLC6A6chr314526375+0.0025728280.99742717

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Fusion Genomic Features for FGD5-SLC6A6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGD5chr314863103+SLC6A6chr314526374+0.0013091070.9986909
FGD5chr314863103+SLC6A6chr314526374+0.0013091070.9986909

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGD5-SLC6A6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:14863103/chr3:14526375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGD5

Q6ZNL6

.
FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGD5chr3:14863103chr3:14526375ENST00000285046+12058_3238411463.0Compositional biasNote=Glu-rich
HgeneFGD5chr3:14863103chr3:14526375ENST00000285046+120645_6508411463.0Compositional biasNote=Poly-Lys
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605143_2170201.0Topological domainExtracellular
TgeneSLC6A6chr3:14863103chr3:14526375ENST00000416216051_490201.0Topological domainCytoplasmic
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605564_6200201.0Topological domainCytoplasmic
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605122_1420201.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605218_2360201.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605245_2620201.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605298_3150201.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605327_3480201.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605381_4000201.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605430_4480201.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605465_4850201.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605506_5250201.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004162160550_700201.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000041621605545_5630201.0TransmembraneHelical%3B Name%3D12
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004162160578_970201.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGD5chr3:14863103chr3:14526375ENST00000285046+1201113_12078411463.0DomainPH 1
HgeneFGD5chr3:14863103chr3:14526375ENST00000285046+1201363_14618411463.0DomainPH 2
HgeneFGD5chr3:14863103chr3:14526375ENST00000285046+120892_10848411463.0DomainDH
HgeneFGD5chr3:14863103chr3:14526375ENST00000285046+1201242_13018411463.0Zinc fingerFYVE-type
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315143_217574621.0Topological domainExtracellular
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000036086113151_49574621.0Topological domainCytoplasmic
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315564_620574621.0Topological domainCytoplasmic
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315143_217574621.0Topological domainExtracellular
TgeneSLC6A6chr3:14863103chr3:14526375ENST0000045487613151_49574621.0Topological domainCytoplasmic
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315564_620574621.0Topological domainCytoplasmic
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315122_142574621.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315218_236574621.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315245_262574621.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315298_315574621.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315327_348574621.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315381_400574621.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315430_448574621.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315465_485574621.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315506_525574621.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A6chr3:14863103chr3:14526375ENST00000360861131550_70574621.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A6chr3:14863103chr3:14526375ENST000003608611315545_563574621.0TransmembraneHelical%3B Name%3D12
TgeneSLC6A6chr3:14863103chr3:14526375ENST00000360861131578_97574621.0TransmembraneHelical%3B Name%3D2
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315122_142574621.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315218_236574621.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315245_262574621.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315298_315574621.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315327_348574621.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315381_400574621.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315430_448574621.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315465_485574621.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315506_525574621.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A6chr3:14863103chr3:14526375ENST00000454876131550_70574621.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A6chr3:14863103chr3:14526375ENST000004548761315545_563574621.0TransmembraneHelical%3B Name%3D12
TgeneSLC6A6chr3:14863103chr3:14526375ENST00000454876131578_97574621.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for FGD5-SLC6A6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30181_30181_1_FGD5-SLC6A6_FGD5_chr3_14863103_ENST00000285046_SLC6A6_chr3_14526375_ENST00000454876_length(transcript)=7118nt_BP=2635nt
CAAAACCACCTGTCGCTCCCAAGCCAAAGACTACCAGTCCACTGACGCCAGTGACCGCGCCCAAATTCCCTTCCTCAGCCAGGCCCGAGA
GTCTTCACAGTCCAAACTCCATGTTCAGGGGTCCGAAGCCCCCCATTGCCCCCAAGCCCAGGCTGACTGCCCCAAACGAGTGGAGAGCCA
GTGTGTACCTGAATGACAGCTTGAACAAATGCAGCAACGGGCGGCTGCCCTGTGTAGACAGGGGGCTTGATGAGGGGCCCCGGTCCATCC
CAAAGTGCTCTGAGTCGGAGACCGACGAGGATTACATCGTGGTCCCCAGGGTTCCGCTGAGGGAGGATGAACCCAAGGACGAGGGCAGTG
TGGGGAACAAAGCCCTGGTGTCTCCCGAGTCCTCTGCGGAAGAGGAAGAGGAGCGTGAAGAGGGAGGCGAGGCATGTGGCCTGGAGGGTA
CAGGAGCTGGTGAGGATTCAGTGGCCCCTGCTGCTCCGGGTGCAGGAGCGCTGAGCAGGGAGGGTGAGGAAGGCACAGACCTTGCTCTTG
AGGATGAAGGGGAGGGCTGCGCTGATGAGCCAGGGACACTGGAGCAGGTGTCCAGAAGTGAGGAGGAAGAGAAGCTAGTGCAGCCACACA
GGGAGTGCAGCCTGGAGGACAGTGGGCCTTGGGCTGGAGAGGGGGTCTTCCAGAGCGACCTCCTCCTGCCTCACATCCATGGAGAGGACC
AGGAGCCCCCCGACACCCCCGGGGAGGCAGAGGAGGATGATGAGGAAGGCTGTGCCAGCACAGACCCAGCAGGGGCAGATGAGGGTTCGG
GTCCTGACAGGCCCACGGAGGACATGGGACAGGATGCTGAGGACACCAGTGAGGAGCCCCCTGAGAAGGAGGAGCTGGCCGGGGTCCAGG
AGGCAGAGACAGCCACAGACTGCCCTGAAGTTCTTGAGGAGGGATGTGAAGAGGCCACGGGTGTCACAGGTGGGGAACAGGTTGACCTCA
GTGAACCACCTGACCACGAGAAGAAAACCAACCAAGAAGTGGCAGCCGCCACCCTGGAGGACCATGCACAGGATGAGTCCGCCGAGGAGA
GCTGCCAGATTGTCCCTTTTGAGAATGACTGCATGGAGGACTTCGTGACTTCCCTCACAGGAAGCCCCTATGAGTTCTTCCCAACTGAGA
GCACCTCTTTTTGCAGCGAGAGCTGTTCTCCTCTTTCTGAATCAGCGAAAGGTTTAGAATCAGAGCAGGCACCAAAGCTGGGGCTGCGTG
CGGAGGAGAACCCCATGGTGGGGGCTTTGTGTGGCCAGTGTGGCTCCCTACAGGGTGGAGCGGCCGAGGGTCCCGCAGCCCCTGATGTGG
TGGTCGTGCTGGAGGAGGAGGCCTTGGATGATGCACTGGCCAACCCCTATGTGATGGGAGTGGGCCTGCCCGGTCAGGCGGCCCCTGGAG
AAGGAGGGCAGGCTGCATCGGACGCCCTGGGTGGTTATGGCTCGAAAGAAGAATTGAACTGTGAGGCAGAGGGTGGCCTGGTTCCCGCGG
ACAGGAAGAACACCAGCACGAGGGTCCGGCCCCACTCTGGGAAGGTGGCCGGCTATGTCCCAGAAACCGTCCCTGAAGAAACCGGACCTG
AGGCGGGCTCGTCAGCCCCTGGCATTGGAGGTGCCGCAGAGGAGGTGGGAAAGACGCTTTTGTCATTGGAGGGGAAGCCCTTGGAAGCCA
GCAGGGCCTTGCCAGCAAAGCCCAGGGCCTTTACTTTATACCCTCGGTCGTTCTCCGTGGAAGGCCGAGAGATTCCAGTGTCCGTGTACC
AGGAGCCTGAGGGGTCAGGGTTGGATGACCACAGGATAAAGAGGAAAGAGGACAATCTCTCTCTGTCGTGTGTAATTGGCTCCTCTGGGA
GTTTCTCCCAGAGAAACCACCTTCCGTCCAGCGGCACCTCCACGCCTTCTTCCATGGTCGACATCCCACCTCCTTTCGACCTGGCCTGCA
TCACCAAGAAGCCCATCACAAAGAGCTCTCCCTCACTCCTGATCGAGAGCGACTCCCCGGACAAGTACAAGAAGAAGAAGTCATCCTTTA
AGCGCTTCCTGGCACTGACGTTTAAGAAGAAGACGGAGAACAAATTGCATGTGGATGTGAACGTGTCTTCCTCTAGGTCCTCTTCAGAGT
CCAGCTACCACGGGCCTTCCAGGATTCTGGAAGTTGACCGGAGAAGCCTCAGCAACTCCCCTCAGCTTAAGTCTCGGACTGGGAAGCTCC
GGGCTTCTGAATCCCCCTCCTCCCTCATCTTTTATAGAGATGGCAAGAGGAAAGGTGTCCCCTTCAGCAGGACGGTGTCCAGAGTGGAGT
CCTTTGAAGACCGCTCCCGGCCGCCCTTCCTGCCCTTGCCACTGACCAAGCCACGGTCCATCTCCTTCCCCAGCGCTGACACTTCAGACT
ATGAGAACATTCCAGCCATGAACTCGGACTATGAGAATATCCAGATTCCACCCCGGAGACCTGCCAGGGCTGGCGCGTTCACGAAGCTGT
TTGAAGATCAGAGCAGAGCCCTGTCCACAGCAAACGAAAATGATGGCTACGTGGACATGAGCAGCTTCAACGCCTTTGAGAGCAAACAGC
AGAGTGCAGACCAGGACGCAGAAAGAGAGTCAAGTACCTGCTGACCCCAAGGGAACCCAACCGCTGGGCTGTGGAGCGCGAGGGAGCCAC
ACCTTACAACTCTCGCACCGTCATGAACGGCGCTCTCGTGAAACCGACCCACATCATTGTGGAGACCATGATGTGAGCTCTCTCGGGTCG
ACGGGGCCGGCGGCTTTCCTGCTGTTTACTAACATTAGATTCTCATAGGACCAGGTTTACAGAGCTTTATATTTGCACTAGGATTTTTTT
TTTTTTGTAATTGTCACAGAAAATGTAATTGTGGGTATGTGTGCGTGCGTGTGTGTGTGTGTGTGTATCGTGTGTGTGTGTTTTGTTTTG
ATTTGGGGGATATTTTGTACAAAAAGAAAACCCACGGGAAGATGTCCGTGGAGAGGCAGAGCTTTCATACTGAATTAGATGTATTTTATG
GGAATTTGGTAAATTTTTCTTTGTATTTTTTTTTTTACATATAAGTATATATACACTTAGAGATTGTCATATACTTTTACCACTTGAATT
GATCTTCTTGCCAGCAATAGATCTCATTTTCAAAAGCAATTCTTCGGTGCTGTGTAGCTGGCAGAAAGTTCTGTCCAGTAAACGCAGGAT
GGAATTTTCCTGGGACTCTACACCCATCTTAAGGTGGTATACCTTCCAAATCCTGGTTCAGATGGAAGAAATAGCAGGAGAGAGGACCCA
TTAGCTGGCAGACCCAGGGGGAAGAAAGGAGGGCTGTGAGGAGATACCTCATTAAACTTGGCTTAGTGAAGAAGAGAGATGCCAAAGGAA
TGAACCAACCCTTCACATAAAGGAGACTGGCTGAAGCTGAATGAGGAGGCCCTATAGCAGAAGTCTGATTCTAAGAGCAGTAGAAACTTG
TACCAGAAGCAAAATCCCACTTTTAATTTTGAGATGGTGAGTGGATAGTCAGTAGACCGTCAGAACCACTGGCCAGAGAGGGAGCTGCTA
GAGATCCAAGAAGGCTGGCAGGAGTGAGGCTCACAACTCAGCCTCGCAAGAGGTGGCAGAGGCACAGGAGGCCACAGTCCTTCCTGGGGC
ATTCCAGGCAGAGAAGGAGCAGAGGCTCTCCCGGCAGGAGCTGGGGTCTCAGGGCTCAGATGAGTCTGTTGCATTTGAATGGGGTCATAG
CAGGTTCTGGTCATTCCCCAAGCAACATCTCAGCATCTCTTAAAGTTGCCTGCAGGAATGAAGCATGACATACCTGTTGAGGGACTAGGG
GAGTGGTGGGGAGGTGAGTGGACCAAAGGATATAGGCCCCAGGCATGCAGATGGGCCCGGTGTCGGGGAGGGGTGCTTTCTTTCCTCATC
TCCCCACTCCCCACTCTCAGCCTGGGAGACTCCTGCCAAGCCCTCATTAAAGATGCCACCCTGGGCTGCCCTGGCACCTAGCAAGGCACA
CCAAGAACAGCTTTTGAGTCTGTATCCTCCACTGGGGGAAGTGCTCCCAGTTCAGAACAAGGGCAGCCCGTGGTGCTGACCTAGGATATA
ACAAAGCTCTTCACTTCAAAACCCCTGCAATAGCTGGGTTTACAGACATTTACCACCTGCGGACCCAAAAGAGAAGGCCTAGGAGAGTTT
TCTAGAAGGTTGGGATTGTCAGGGTCCTGGCCCCTCAGAACTGGCTTGATCAAGGGCCTTATGTGGAGCAGAGGTTGTCTCTGAACCAGG
AGAGAAGGTACTATACCTTTCAAATCCCCAGGGCAGACACACCCCCACCCAGCCCCTATTTGGACCTAAACTGTGCCATTTGAACAGTCA
CTTCCAAGCTCAGTCTAAATGAAACCGAAACGTGACCACGCACAAAGGCAGTCACTGCCTCGAGGGGTGCAGACCGCAGAATTTTCACAG
CAGGGGCTCTTGGAACCCTGGAAACCCCCTTCTTAAATTTGGGAGGAGGAGTATGCCTTTGGTGTCCCCCTCCCAAGGGGCAATTCTGAA
CCCCATCTTTGGCAGGCATACATATTTCACTGTTTCCAAAGCTATCTACTCTGCCAAACAACACCCAGTCCTATTCCAAACTCTCAACGA
TTCTATCTTGTTCCTGTTTTTCTATGTATTTATGGTTGCCGTTTGTGTCTGATTTGATTTTACTGTTTTTTCCCTGATTTTATGGAGTAG
CATTGTGACCTGTTTTCCTTTGTCTTATATAACTTTAGTAAACTAACCACTGTCAATGATTGAGGGCAGGTGGCACGTGGGGAAGAGGGG
ACTTGGCACGCAGTGGCTACCTGGGCATTTGTGGTCATTTCAGTTTCCATCTCCCCAGCGGGGGCTCCCTGGGTGAAAGGCCACAGTATT
TTGGGTTGGTAGGCAAATTGCAACATTCTGGACATGGCCTGAGGAAGGCCTCTTCTTATAAGATTCTCAGACCAAATTCTAGACCAAAGA
CACAGGCAGACCAAGTCCCCAGGCCCCGCCTGGAAGGAAGTCGTTCCTCAACTCTCCCCAAGGCACCTGTCTCCAATCAGAGCCCTCTCG
CCCAGCCAGCCCTGGCTCTGTGTGCAGAGCATAGCTCTGCGAGTACCTGTGTAATAATGCTCAACCTTCATGTCTCCGTATAAACGAAAC
TTTCCATGAGAGCTCATGACTCTGGTCCACCTGTCTATAGAGAATGGGCAAAGTCCTTCACCTGCTTTCTGCTTGGGATGGGTCAGAAAT
GCTGATGCCCGCACATAGCCCAGCCAGCCAGATCTGGAAAGGAAGCGAGGGGGTTGTTTAAATCAATTTTTTAAGATGAAGAAGTGGGAG
ACACTGCGTTGAGATGGGCCATGCTAGGGCCACAGAGATTTCCTGACGGTCAGGGAGAGAAGGGCCTCCAGGGTCCCCTAACCCAACGCC
CTTGTTGTAAATGAGGTAACTGAGGCTCAGGGAGGCACTGTGAGCCAGGAATGGATTTTCTTGAAACAGCTCTAGCTGCAGGTTCTCCGA
GGTAGGTGCAGGGAATGGTGAGTGTCTAACCAGGGCTACATCCAGCAACATCCTCAAGGTCTTCCTGACAACCAAAGACAAGCCTTTATG
GAAAAGGAAATGCGCTCCCCTCCATGTTCAGGGATGAGGGGAGCAGCAGCAGCCACACTCCCACCATCCTCACAGAATTCCTGGACCCAT
GCGGTGGCTCCGTGAGCTGGGTGACTCCAGCCTCACCTGCACACCCCAGCCCTGCACGGGGCCCTCCTTCCTCCCAGCAGCCCTTGGTGA
GCTAGGAATTGAGATCCCTGTTTGTGAAAGAGGGAACTGAGGTGCAGAGAAGCCAGAGGTGTGCCAGATCCTTAGGCAGGATTTAGATGA
AGTCGCCCTGGCTCCAGACTGACCCCGAGGCTCTGCGGGGAGTTTCCAGGCAGCAGGAAGTGGCCTTGGATGCTCTCCTTCCAGGACAGC
ATAACCCCTGGGCCATGTGCAGCTCCTTCACTGCCCCCTGGATCCCCAGCATACCCCCAAAGACAGTGGGGAAACACAAGGGGAGAGCAC
AGCATGGCCCCTCCAGCCCACTTCAGGGCACTCTTGTATCACCCGGGTACCGCCACACTGGTCCCCCACCCAGCCAGCATCTCCCAGCAC
AGCCCCTCTCCCTGGGGAAATGCTCTGGGTAGCCAGTCTAAAGGCAGAGGCACCTAACTGCTCCCCGCAGCCCACCCCACCCAAGATTCA
GACACAAGCCAGGAAAGGACCCAAGAGAAAATCCTTCAAGGTGGCCTGAGGTCCCATCCCTCCCTCAGACCCATGTGGTCCCAGGCCAGG
CTGCCTGGGACACGGTAAATACCACTGTGTGCAAAAATCGAAGTACAAAACCACAAGACTAAACAAAACAAACCCAGAGAGCCAAACTTG
TAGAGGTGGGCAGTCCAGAAAGCAGGGGGCAGCCCTCCCCCTTTCCTTCTCTCCCTGATCCTCAGAATATATATTGTTGTAATAGGAAGC
ATTTTTGCATTGTTCTCTTGTGGGTGTCACTACAGACATGTTCTGGCGTGTTCTCCGAGGGATGGAGCATCCTGTTATATATTTGACTTC
AAATTGAGATGTTGGCTTCATTTTTTTTTTTTACCCAATTAATCTCCCAATCCCTAGCAACTGTGACTCTGTATTTAGCACAAGAGAAAG
CTGAGAATGTGGGTCTTGCCTCCTTCCAGAAATATGTCTGGCTCATCAGGACATTTTTTTAAAACTTCAAAATATTTTTAAGATATTTTA
AACTTTTATAAAAAAAAAATCAACCAACAAGAGACTTTTCTGAGGAGGAACATTTGTATTTGAACAAGATCCTTGGTGTGTAGTTCAGTC
TTGCAGTATACAAGCTTTTGTGTATAAATGTTTTATGATATGATTCCCTGTATTTTGCAGGGGTTTTTTTCTCTTTTGCTTTTTAGATAA
ATATGTATATCAATATTTTAAATTCATCTTTGCTTTTTTTAGAGGAGTTTGTAATCACCTTATAACATGAAAATAAACATTTCCTTTTTA

>30181_30181_1_FGD5-SLC6A6_FGD5_chr3_14863103_ENST00000285046_SLC6A6_chr3_14526375_ENST00000454876_length(amino acids)=870AA_BP=
MTPVTAPKFPSSARPESLHSPNSMFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESETDEDYIV
VPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTL
EQVSRSEEEEKLVQPHRECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAE
DTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMED
FVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALA
NPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAE
EVGKTLLSLEGKPLEASRALPAKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNHLPSSGTS
TPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDR
RSLSNSPQLKSRTGKLRASESPSSLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAMNSDYENI

--------------------------------------------------------------
>30181_30181_2_FGD5-SLC6A6_FGD5_chr3_14863103_ENST00000543601_SLC6A6_chr3_14526375_ENST00000454876_length(transcript)=6756nt_BP=2273nt
GGGAACAAAGCCCTGGTGTCTCCCGAGTCCTCTGCGGAAGAGGAAGAGGAGCGTGAAGAGGGAGGCGAGGCATGTGGCCTGGAGGGTACA
GGAGCTGGTGAGGATTCAGTGGCCCCTGCTGCTCCGGGTGCAGGAGCGCTGAGCAGGGAGGGTGAGGAAGGCACAGACCTTGCTCTTGAG
GATGAAGGGGAGGGCTGCGCTGATGAGCCAGGGACACTGGAGCAGGTGTCCAGAAGTGAGGAGGAAGAGAAGCTAGTGCAGCCACACAGG
GAGTGCAGCCTGGAGGACAGTGGGCCTTGGGCTGGAGAGGGGGTCTTCCAGAGCGACCTCCTCCTGCCTCACATCCATGGAGAGGACCAG
GAGCCCCCCGACACCCCCGGGGAGGCAGAGGAGGATGATGAGGAAGGCTGTGCCAGCACAGACCCAGCAGGGGCAGATGAGGGTTCGGGT
CCTGACAGGCCCACGGAGGACATGGGACAGGATGCTGAGGACACCAGTGAGGAGCCCCCTGAGAAGGAGGAGCTGGCCGGGGTCCAGGAG
GCAGAGACAGCCACAGACTGCCCTGAAGTTCTTGAGGAGGGATGTGAAGAGGCCACGGGTGTCACAGGTGGGGAACAGGTTGACCTCAGT
GAACCACCTGACCACGAGAAGAAAACCAACCAAGAAGTGGCAGCCGCCACCCTGGAGGACCATGCACAGGATGAGTCCGCCGAGGAGAGC
TGCCAGATTGTCCCTTTTGAGAATGACTGCATGGAGGACTTCGTGACTTCCCTCACAGGAAGCCCCTATGAGTTCTTCCCAACTGAGAGC
ACCTCTTTTTGCAGCGAGAGCTGTTCTCCTCTTTCTGAATCAGCGAAAGGTTTAGAATCAGAGCAGGCACCAAAGCTGGGGCTGCGTGCG
GAGGAGAACCCCATGGTGGGGGCTTTGTGTGGCCAGTGTGGCTCCCTACAGGGTGGAGCGGCCGAGGGTCCCGCAGCCCCTGATGTGGTG
GTCGTGCTGGAGGAGGAGGCCTTGGATGATGCACTGGCCAACCCCTATGTGATGGGAGTGGGCCTGCCCGGTCAGGCGGCCCCTGGAGAA
GGAGGGCAGGCTGCATCGGACGCCCTGGGTGGTTATGGCTCGAAAGAAGAATTGAACTGTGAGGCAGAGGGTGGCCTGGTTCCCGCGGAC
AGGAAGAACACCAGCACGAGGGTCCGGCCCCACTCTGGGAAGGTGGCCGGCTATGTCCCAGAAACCGTCCCTGAAGAAACCGGACCTGAG
GCGGGCTCGTCAGCCCCTGGCATTGGAGGTGCCGCAGAGGAGGTGGGAAAGACGCTTTTGTCATTGGAGGGGAAGCCCTTGGAAGCCAGC
AGGGCCTTGCCAGCAAAGCCCAGGGCCTTTACTTTATACCCTCGGTCGTTCTCCGTGGAAGGCCGAGAGATTCCAGTGTCCGTGTACCAG
GAGCCTGAGGGGTCAGGGTTGGATGACCACAGGATAAAGAGGAAAGAGGACAATCTCTCTCTGTCGTGTGTAATTGGCTCCTCTGGGAGT
TTCTCCCAGAGAAACCACCTTCCGTCCAGCGGCACCTCCACGCCTTCTTCCATGGTCGACATCCCACCTCCTTTCGACCTGGCCTGCATC
ACCAAGAAGCCCATCACAAAGAGCTCTCCCTCACTCCTGATCGAGAGCGACTCCCCGGACAAGTACAAGAAGAAGAAGTCATCCTTTAAG
CGCTTCCTGGCACTGACGTTTAAGAAGAAGACGGAGAACAAATTGCATGTGGATGTGAACGTGTCTTCCTCTAGGTCCTCTTCAGAGTCC
AGCTACCACGGGCCTTCCAGGATTCTGGAAGTTGACCGGAGAAGCCTCAGCAACTCCCCTCAGCTTAAGTCTCGGACTGGGAAGCTCCGG
GCTTCTGAATCCCCCTCCTCCCTCATCTTTTATAGAGATGGCAAGAGGAAAGGTGTCCCCTTCAGCAGGACGGTGTCCAGAGTGGAGTCC
TTTGAAGACCGCTCCCGGCCGCCCTTCCTGCCCTTGCCACTGACCAAGCCACGGTCCATCTCCTTCCCCAGCGCTGACACTTCAGACTAT
GAGAACATTCCAGCCATGAACTCGGACTATGAGAATATCCAGATTCCACCCCGGAGACCTGCCAGGGCTGGCGCGTTCACGAAGCTGTTT
GAAGATCAGAGCAGAGCCCTGTCCACAGCAAACGAAAATGATGGCTACGTGGACATGAGCAGCTTCAACGCCTTTGAGAGCAAACAGCAG
AGTGCAGACCAGGACGCAGAAAGAGAGTCAAGTACCTGCTGACCCCAAGGGAACCCAACCGCTGGGCTGTGGAGCGCGAGGGAGCCACAC
CTTACAACTCTCGCACCGTCATGAACGGCGCTCTCGTGAAACCGACCCACATCATTGTGGAGACCATGATGTGAGCTCTCTCGGGTCGAC
GGGGCCGGCGGCTTTCCTGCTGTTTACTAACATTAGATTCTCATAGGACCAGGTTTACAGAGCTTTATATTTGCACTAGGATTTTTTTTT
TTTTGTAATTGTCACAGAAAATGTAATTGTGGGTATGTGTGCGTGCGTGTGTGTGTGTGTGTGTATCGTGTGTGTGTGTTTTGTTTTGAT
TTGGGGGATATTTTGTACAAAAAGAAAACCCACGGGAAGATGTCCGTGGAGAGGCAGAGCTTTCATACTGAATTAGATGTATTTTATGGG
AATTTGGTAAATTTTTCTTTGTATTTTTTTTTTTACATATAAGTATATATACACTTAGAGATTGTCATATACTTTTACCACTTGAATTGA
TCTTCTTGCCAGCAATAGATCTCATTTTCAAAAGCAATTCTTCGGTGCTGTGTAGCTGGCAGAAAGTTCTGTCCAGTAAACGCAGGATGG
AATTTTCCTGGGACTCTACACCCATCTTAAGGTGGTATACCTTCCAAATCCTGGTTCAGATGGAAGAAATAGCAGGAGAGAGGACCCATT
AGCTGGCAGACCCAGGGGGAAGAAAGGAGGGCTGTGAGGAGATACCTCATTAAACTTGGCTTAGTGAAGAAGAGAGATGCCAAAGGAATG
AACCAACCCTTCACATAAAGGAGACTGGCTGAAGCTGAATGAGGAGGCCCTATAGCAGAAGTCTGATTCTAAGAGCAGTAGAAACTTGTA
CCAGAAGCAAAATCCCACTTTTAATTTTGAGATGGTGAGTGGATAGTCAGTAGACCGTCAGAACCACTGGCCAGAGAGGGAGCTGCTAGA
GATCCAAGAAGGCTGGCAGGAGTGAGGCTCACAACTCAGCCTCGCAAGAGGTGGCAGAGGCACAGGAGGCCACAGTCCTTCCTGGGGCAT
TCCAGGCAGAGAAGGAGCAGAGGCTCTCCCGGCAGGAGCTGGGGTCTCAGGGCTCAGATGAGTCTGTTGCATTTGAATGGGGTCATAGCA
GGTTCTGGTCATTCCCCAAGCAACATCTCAGCATCTCTTAAAGTTGCCTGCAGGAATGAAGCATGACATACCTGTTGAGGGACTAGGGGA
GTGGTGGGGAGGTGAGTGGACCAAAGGATATAGGCCCCAGGCATGCAGATGGGCCCGGTGTCGGGGAGGGGTGCTTTCTTTCCTCATCTC
CCCACTCCCCACTCTCAGCCTGGGAGACTCCTGCCAAGCCCTCATTAAAGATGCCACCCTGGGCTGCCCTGGCACCTAGCAAGGCACACC
AAGAACAGCTTTTGAGTCTGTATCCTCCACTGGGGGAAGTGCTCCCAGTTCAGAACAAGGGCAGCCCGTGGTGCTGACCTAGGATATAAC
AAAGCTCTTCACTTCAAAACCCCTGCAATAGCTGGGTTTACAGACATTTACCACCTGCGGACCCAAAAGAGAAGGCCTAGGAGAGTTTTC
TAGAAGGTTGGGATTGTCAGGGTCCTGGCCCCTCAGAACTGGCTTGATCAAGGGCCTTATGTGGAGCAGAGGTTGTCTCTGAACCAGGAG
AGAAGGTACTATACCTTTCAAATCCCCAGGGCAGACACACCCCCACCCAGCCCCTATTTGGACCTAAACTGTGCCATTTGAACAGTCACT
TCCAAGCTCAGTCTAAATGAAACCGAAACGTGACCACGCACAAAGGCAGTCACTGCCTCGAGGGGTGCAGACCGCAGAATTTTCACAGCA
GGGGCTCTTGGAACCCTGGAAACCCCCTTCTTAAATTTGGGAGGAGGAGTATGCCTTTGGTGTCCCCCTCCCAAGGGGCAATTCTGAACC
CCATCTTTGGCAGGCATACATATTTCACTGTTTCCAAAGCTATCTACTCTGCCAAACAACACCCAGTCCTATTCCAAACTCTCAACGATT
CTATCTTGTTCCTGTTTTTCTATGTATTTATGGTTGCCGTTTGTGTCTGATTTGATTTTACTGTTTTTTCCCTGATTTTATGGAGTAGCA
TTGTGACCTGTTTTCCTTTGTCTTATATAACTTTAGTAAACTAACCACTGTCAATGATTGAGGGCAGGTGGCACGTGGGGAAGAGGGGAC
TTGGCACGCAGTGGCTACCTGGGCATTTGTGGTCATTTCAGTTTCCATCTCCCCAGCGGGGGCTCCCTGGGTGAAAGGCCACAGTATTTT
GGGTTGGTAGGCAAATTGCAACATTCTGGACATGGCCTGAGGAAGGCCTCTTCTTATAAGATTCTCAGACCAAATTCTAGACCAAAGACA
CAGGCAGACCAAGTCCCCAGGCCCCGCCTGGAAGGAAGTCGTTCCTCAACTCTCCCCAAGGCACCTGTCTCCAATCAGAGCCCTCTCGCC
CAGCCAGCCCTGGCTCTGTGTGCAGAGCATAGCTCTGCGAGTACCTGTGTAATAATGCTCAACCTTCATGTCTCCGTATAAACGAAACTT
TCCATGAGAGCTCATGACTCTGGTCCACCTGTCTATAGAGAATGGGCAAAGTCCTTCACCTGCTTTCTGCTTGGGATGGGTCAGAAATGC
TGATGCCCGCACATAGCCCAGCCAGCCAGATCTGGAAAGGAAGCGAGGGGGTTGTTTAAATCAATTTTTTAAGATGAAGAAGTGGGAGAC
ACTGCGTTGAGATGGGCCATGCTAGGGCCACAGAGATTTCCTGACGGTCAGGGAGAGAAGGGCCTCCAGGGTCCCCTAACCCAACGCCCT
TGTTGTAAATGAGGTAACTGAGGCTCAGGGAGGCACTGTGAGCCAGGAATGGATTTTCTTGAAACAGCTCTAGCTGCAGGTTCTCCGAGG
TAGGTGCAGGGAATGGTGAGTGTCTAACCAGGGCTACATCCAGCAACATCCTCAAGGTCTTCCTGACAACCAAAGACAAGCCTTTATGGA
AAAGGAAATGCGCTCCCCTCCATGTTCAGGGATGAGGGGAGCAGCAGCAGCCACACTCCCACCATCCTCACAGAATTCCTGGACCCATGC
GGTGGCTCCGTGAGCTGGGTGACTCCAGCCTCACCTGCACACCCCAGCCCTGCACGGGGCCCTCCTTCCTCCCAGCAGCCCTTGGTGAGC
TAGGAATTGAGATCCCTGTTTGTGAAAGAGGGAACTGAGGTGCAGAGAAGCCAGAGGTGTGCCAGATCCTTAGGCAGGATTTAGATGAAG
TCGCCCTGGCTCCAGACTGACCCCGAGGCTCTGCGGGGAGTTTCCAGGCAGCAGGAAGTGGCCTTGGATGCTCTCCTTCCAGGACAGCAT
AACCCCTGGGCCATGTGCAGCTCCTTCACTGCCCCCTGGATCCCCAGCATACCCCCAAAGACAGTGGGGAAACACAAGGGGAGAGCACAG
CATGGCCCCTCCAGCCCACTTCAGGGCACTCTTGTATCACCCGGGTACCGCCACACTGGTCCCCCACCCAGCCAGCATCTCCCAGCACAG
CCCCTCTCCCTGGGGAAATGCTCTGGGTAGCCAGTCTAAAGGCAGAGGCACCTAACTGCTCCCCGCAGCCCACCCCACCCAAGATTCAGA
CACAAGCCAGGAAAGGACCCAAGAGAAAATCCTTCAAGGTGGCCTGAGGTCCCATCCCTCCCTCAGACCCATGTGGTCCCAGGCCAGGCT
GCCTGGGACACGGTAAATACCACTGTGTGCAAAAATCGAAGTACAAAACCACAAGACTAAACAAAACAAACCCAGAGAGCCAAACTTGTA
GAGGTGGGCAGTCCAGAAAGCAGGGGGCAGCCCTCCCCCTTTCCTTCTCTCCCTGATCCTCAGAATATATATTGTTGTAATAGGAAGCAT
TTTTGCATTGTTCTCTTGTGGGTGTCACTACAGACATGTTCTGGCGTGTTCTCCGAGGGATGGAGCATCCTGTTATATATTTGACTTCAA
ATTGAGATGTTGGCTTCATTTTTTTTTTTTACCCAATTAATCTCCCAATCCCTAGCAACTGTGACTCTGTATTTAGCACAAGAGAAAGCT
GAGAATGTGGGTCTTGCCTCCTTCCAGAAATATGTCTGGCTCATCAGGACATTTTTTTAAAACTTCAAAATATTTTTAAGATATTTTAAA
CTTTTATAAAAAAAAAATCAACCAACAAGAGACTTTTCTGAGGAGGAACATTTGTATTTGAACAAGATCCTTGGTGTGTAGTTCAGTCTT
GCAGTATACAAGCTTTTGTGTATAAATGTTTTATGATATGATTCCCTGTATTTTGCAGGGGTTTTTTTCTCTTTTGCTTTTTAGATAAAT
ATGTATATCAATATTTTAAATTCATCTTTGCTTTTTTTAGAGGAGTTTGTAATCACCTTATAACATGAAAATAAACATTTCCTTTTTAAC

>30181_30181_2_FGD5-SLC6A6_FGD5_chr3_14863103_ENST00000543601_SLC6A6_chr3_14526375_ENST00000454876_length(amino acids)=759AA_BP=
MVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSL
EDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETA
TDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFC
SESCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALANPYVMGVGLPGQAAPGEGGQA
ASDALGGYGSKEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALP
AKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNHLPSSGTSTPSSMVDIPPPFDLACITKKP
ITKSSPSLLIESDSPDKYKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASES
PSSLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAGAFTKLFEDQS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FGD5-SLC6A6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGD5-SLC6A6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGD5-SLC6A6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource