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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR1-ADAM18 (FusionGDB2 ID:30238)

Fusion Gene Summary for FGFR1-ADAM18

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR1-ADAM18
Fusion gene ID: 30238
HgeneTgene
Gene symbol

FGFR1

ADAM18

Gene ID

2260

8749

Gene namefibroblast growth factor receptor 1ADAM metallopeptidase domain 18
SynonymsBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1ADAM27|tMDCIII
Cytomap

8p11.23

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgrdisintegrin and metalloproteinase domain-containing protein 18a disintegrin and metalloproteinase domain 18transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
Modification date2020032920200313
UniProtAcc

P11362

Q9Y3Q7

Ensembl transtripts involved in fusion geneENST00000326324, ENST00000341462, 
ENST00000356207, ENST00000397091, 
ENST00000397103, ENST00000397108, 
ENST00000397113, ENST00000425967, 
ENST00000447712, ENST00000532791, 
ENST00000335922, ENST00000496629, 
ENST00000541111, ENST00000523755, 
ENST00000265707, ENST00000379866, 
ENST00000520772, 
Fusion gene scores* DoF score17 X 24 X 9=36728 X 8 X 6=384
# samples 209
** MAII scorelog2(20/3672*10)=-4.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR1 [Title/Abstract] AND ADAM18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR1(38314874)-ADAM18(39463826), # samples:3
Anticipated loss of major functional domain due to fusion event.FGFR1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR1-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
FGFR1-ADAM18 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

HgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

HgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

HgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

HgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851


check buttonFusion gene breakpoints across FGFR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAM18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A574-01AFGFR1chr8

38314874

-ADAM18chr8

39463826

+


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Fusion Gene ORF analysis for FGFR1-ADAM18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000326324ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000341462ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000356207ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397091ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397103ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397108ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397113ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000425967ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000447712ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000532791ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000326324ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000341462ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000356207ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397091ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397103ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397108ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397113ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000425967ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000447712ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000532791ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-3CDSENST00000335922ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-3CDSENST00000335922ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-3CDSENST00000335922ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-5UTRENST00000335922ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-intronENST00000335922ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000326324ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000326324ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000326324ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000341462ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000341462ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000341462ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000356207ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000356207ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000356207ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397091ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397091ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397091ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397108ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397108ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397108ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397113ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397113ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397113ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000425967ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000425967ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000425967ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000447712ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000447712ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000447712ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000532791ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000532791ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000532791ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
In-frameENST00000397103ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
In-frameENST00000397103ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
In-frameENST00000397103ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-3CDSENST00000496629ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-3CDSENST00000496629ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-3CDSENST00000496629ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-5UTRENST00000496629ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-intronENST00000496629ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397103FGFR1chr838314874-ENST00000265707ADAM18chr839463826+2359148522235727
ENST00000397103FGFR1chr838314874-ENST00000379866ADAM18chr839463826+2288148522163703
ENST00000397103FGFR1chr838314874-ENST00000520772ADAM18chr839463826+140714852564170

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397103ENST00000265707FGFR1chr838314874-ADAM18chr839463826+8.33E-050.9999168
ENST00000397103ENST00000379866FGFR1chr838314874-ADAM18chr839463826+8.59E-050.99991417
ENST00000397103ENST00000520772FGFR1chr838314874-ADAM18chr839463826+0.0094163910.99058366

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Fusion Genomic Features for FGFR1-ADAM18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGFR1chr838314873-ADAM18chr839463825+1.42E-050.9999858
FGFR1chr838314873-ADAM18chr839463825+1.42E-050.9999858

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGFR1-ADAM18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38314874/chr8:39463826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR1

P11362

ADAM18

Q9Y3Q7

FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.FUNCTION: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM18chr8:38314874chr8:39463826ENST00000265707120480_62244740.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38314874chr8:39463826ENST00000379866119480_62244716.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38314874chr8:39463826ENST0000052077216480_62244183.0Compositional biasNote=Cys-rich
TgeneADAM18chr8:38314874chr8:39463826ENST00000265707120184_38144740.0DomainPeptidase M12B
TgeneADAM18chr8:38314874chr8:39463826ENST00000265707120390_47944740.0DomainDisintegrin
TgeneADAM18chr8:38314874chr8:39463826ENST00000265707120620_65444740.0DomainNote=EGF-like
TgeneADAM18chr8:38314874chr8:39463826ENST00000379866119184_38144716.0DomainPeptidase M12B
TgeneADAM18chr8:38314874chr8:39463826ENST00000379866119390_47944716.0DomainDisintegrin
TgeneADAM18chr8:38314874chr8:39463826ENST00000379866119620_65444716.0DomainNote=EGF-like
TgeneADAM18chr8:38314874chr8:39463826ENST0000052077216184_38144183.0DomainPeptidase M12B
TgeneADAM18chr8:38314874chr8:39463826ENST0000052077216390_47944183.0DomainDisintegrin
TgeneADAM18chr8:38314874chr8:39463826ENST0000052077216620_65444183.0DomainNote=EGF-like
TgeneADAM18chr8:38314874chr8:39463826ENST00000265707120177_68744740.0Topological domainExtracellular
TgeneADAM18chr8:38314874chr8:39463826ENST00000265707120709_73944740.0Topological domainCytoplasmic
TgeneADAM18chr8:38314874chr8:39463826ENST00000379866119177_68744716.0Topological domainExtracellular
TgeneADAM18chr8:38314874chr8:39463826ENST00000379866119709_73944716.0Topological domainCytoplasmic
TgeneADAM18chr8:38314874chr8:39463826ENST0000052077216177_68744183.0Topological domainExtracellular
TgeneADAM18chr8:38314874chr8:39463826ENST0000052077216709_73944183.0Topological domainCytoplasmic
TgeneADAM18chr8:38314874chr8:39463826ENST00000265707120688_70844740.0TransmembraneHelical
TgeneADAM18chr8:38314874chr8:39463826ENST00000379866119688_70844716.0TransmembraneHelical
TgeneADAM18chr8:38314874chr8:39463826ENST0000052077216688_70844183.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217158_24630732.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217255_35730732.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-21725_11930732.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217478_76730732.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219158_2460813.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219255_3570813.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-21925_1190813.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219478_7670813.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217158_24630734.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217255_35730734.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-21725_11930734.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217478_76730734.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-21825_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-31925_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-21825_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319158_24663854.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319255_35763854.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-31925_11963854.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319478_76763854.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218158_24630823.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218255_35730823.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-21825_11930823.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218478_76730823.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-21825_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217484_49030732.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217562_56430732.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219484_4900813.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219562_5640813.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217484_49030734.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217562_56430734.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319484_49063854.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319562_56463854.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218484_49030823.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218562_56430823.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217160_17730732.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219160_1770813.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217160_17730734.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319160_17763854.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218160_17730823.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-21722_37630732.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217398_82230732.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-21922_3760813.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219398_8220813.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-21722_37630734.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217398_82230734.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-21822_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-31922_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-21822_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-31922_37663854.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319398_82263854.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-21822_37630823.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218398_82230823.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-21822_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:39463826ENST00000326324-217377_39730732.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000335922-219377_3970813.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000356207-217377_39730734.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397091-218377_39730821.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397108-319377_39730821.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000397113-218377_39730821.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000425967-319377_39763854.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000447712-218377_39730823.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:39463826ENST00000532791-218377_39730821.0TransmembraneHelical


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Fusion Gene Sequence for FGFR1-ADAM18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30238_30238_1_FGFR1-ADAM18_FGFR1_chr8_38314874_ENST00000397103_ADAM18_chr8_39463826_ENST00000265707_length(transcript)=2359nt_BP=148nt
GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT
GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGATTTACATCATTACAATTGATGGACAACC
TTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATACATATAATGAAACTGGATCTTTGCATTCTGTGTC
TCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTCATTTGTGACACTCAGTATATGTTCTGGTCTCAG
GGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGCAAGATTTGAGCATATAATTTATCAAATGAAAAA
TAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGACCAGCCCTACAAAGTTCCTTTAAACTCACAGAT
AAAAAATCTTTCAAAACTATTACCCCAATATCTGGAAATATACATTATAGTGGAAAAAGCTTTGTATGATTATATGGGATCTGAAATGAT
GGCTGTAACACAAAAAATTGTCCAGGTTATTGGGCTTGTCAACACTATGTTTACCCAGTTCAAATTGACTGTTATACTGTCTTCCTTGGA
ATTGTGGTCAAATGAAAACCAGATTTCCACCAGTGGGGATGCTGATGATATATTACAAAGATTTTTGGCATGGAAACGGGACTATCTCAT
CCTACGGCCCCATGACATAGCATACTTACTTGTTTACAGGAAACATCCTAAATATGTGGGAGCAACATTTCCTGGCACTGTATGCAATAA
AAGCTATGATGCAGGTATTGCTATGTATCCAGATGCAATAGGTTTGGAGGGATTTTCGGTTATTATAGCTCAACTGCTTGGCCTTAATGT
AGGATTAACATATGATGACATCACTCAGTGTTTCTGTCTGAGAGCTACATGCATCATGAATCATGAAGCAGTGAGTGCCAGTGGTAGAAA
GATTTTTAGCAACTGCAGCATGCACGACTATAGATATTTTGTTTCAAAATTTGAGACTAAATGCCTTCAGAAGCTTTCAAATTTGCAACC
ATTACATCAAAATCAACCAGTGTGTGGTAATGGGATTTTGGAATCCAATGAAGAATGTGACTGTGGTAATAAAAATGAATGTCAATTTAA
GAAGTGCTGTGATTATAACACATGTAAACTGAAGGGCTCAGTAAAATGTGGTTCTGGACCATGTTGTACATCAAAGTGTGAGTTGTCAAT
AGCAGGCACTCCATGTAGAAAGAGTATTGATCCAGAGTGTGATTTTACAGAGTACTGCAATGGAACCTCTAGTAATTGTGTTCCTGACAC
TTATGCATTGAATGGCCGTTTGTGCAAGTTGGGAACTGCCTATTGCTATAACGGACAATGTCAAACTACTGATAACCAGTGTGCCAAGAT
ATTTGGAAAAGGTGCTCAAGGTGCTCCATTTGCCTGTTTTAAAGAAGTTAATTCTCTGCATGAAAGATCTGAAAACTGTGGTTTTAAAAA
TTCACAACCATTACCTTGTGAACGGAAGGATGTTCTCTGTGGAAAATTAGCTTGTGTTCAGCCACATAAAAATGCTAATAAAAGTGACGC
TCAATCTACAGTTTATTCATATATTCAAGACCATGTATGTGTATCTATAGCCACTGGTTCCTCCATGAGATCAGATGGAACAGACAATGC
CTATGTGGCTGATGGCACCATGTGTGGTCCAGAAATGTACTGTGTAAATAAAACCTGCAGAAAAGTTCATTTAATGGGATATAACTGTAA
TGCCACCACAAAATGCAAAGGGAAAGGGATATGTAATAATTTTGGTAATTGTCAATGCTTCCCTGGACATAGACCTCCAGATTGTAAATT
CCAGTTTGGTTCCCCAGGGGGTAGTATTGATGATGGAAATTTTCAGAAATCTGGTGACTTTTATACTGAAAAAGGCTACAATACACACTG
GAACAACTGGTTTATTCTGAGTTTCTGCATTTTTCTGCCGTTTTTCATAGTTTTCACCACTGTGATCTTTAAAAGAAATGAAATAAGTAA
ATCATGTAACAGAGAGAATGCAGAGTATAATCGTAATTCATCCGTTGTATCAGAAAGCGATGACGTGGGACATTAATATTGCACAGAACT
TCCATAGCAAATAACCTAAAGGAACGAATGTGCTTTATTTATAACCTTACGTTATCCCCAATGCATTGTAAATGTCAAACTTTTGGAAAA

>30238_30238_1_FGFR1-ADAM18_FGFR1_chr8_38314874_ENST00000397103_ADAM18_chr8_39463826_ENST00000265707_length(amino acids)=727AA_BP=79
MGCGAGSASSSGLCWSQPHSAPLGRPRPCLNKMIYIITIDGQPYTLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFP
NSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIV
EKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPK
YVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKF
ETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTE
YCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLA
CVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNC
QCFPGHRPPDCKFQFGSPGGSIDDGNFQKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVIFKRNEISKSCNRENAEYNRNSSVVS

--------------------------------------------------------------
>30238_30238_2_FGFR1-ADAM18_FGFR1_chr8_38314874_ENST00000397103_ADAM18_chr8_39463826_ENST00000379866_length(transcript)=2288nt_BP=148nt
GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT
GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGATTTACATCATTACAATTGATGGACAACC
TTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATACATATAATGAAACTGGATCTTTGCATTCTGTGTC
TCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTCATTTGTGACACTCAGTATATGTTCTGGTCTCAG
GGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGCAAGATTTGAGCATATAATTTATCAAATGAAAAA
TAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGACCAGCCCTACAAAGTTCCTTTAAACTCACAGAT
AAAAAATCTTTCAAAACTATTACCCCAATATCTGGAAATATACATTATAGTGGAAAAAGCTTTGATGTTTACCCAGTTCAAATTGACTGT
TATACTGTCTTCCTTGGAATTGTGGTCAAATGAAAACCAGATTTCCACCAGTGGGGATGCTGATGATATATTACAAAGATTTTTGGCATG
GAAACGGGACTATCTCATCCTACGGCCCCATGACATAGCATACTTACTTGTTTACAGGAAACATCCTAAATATGTGGGAGCAACATTTCC
TGGCACTGTATGCAATAAAAGCTATGATGCAGGTATTGCTATGTATCCAGATGCAATAGGTTTGGAGGGATTTTCGGTTATTATAGCTCA
ACTGCTTGGCCTTAATGTAGGATTAACATATGATGACATCACTCAGTGTTTCTGTCTGAGAGCTACATGCATCATGAATCATGAAGCAGT
GAGTGCCAGTGGTAGAAAGATTTTTAGCAACTGCAGCATGCACGACTATAGATATTTTGTTTCAAAATTTGAGACTAAATGCCTTCAGAA
GCTTTCAAATTTGCAACCATTACATCAAAATCAACCAGTGTGTGGTAATGGGATTTTGGAATCCAATGAAGAATGTGACTGTGGTAATAA
AAATGAATGTCAATTTAAGAAGTGCTGTGATTATAACACATGTAAACTGAAGGGCTCAGTAAAATGTGGTTCTGGACCATGTTGTACATC
AAAGTGTGAGTTGTCAATAGCAGGCACTCCATGTAGAAAGAGTATTGATCCAGAGTGTGATTTTACAGAGTACTGCAATGGAACCTCTAG
TAATTGTGTTCCTGACACTTATGCATTGAATGGCCGTTTGTGCAAGTTGGGAACTGCCTATTGCTATAACGGACAATGTCAAACTACTGA
TAACCAGTGTGCCAAGATATTTGGAAAAGGTGCTCAAGGTGCTCCATTTGCCTGTTTTAAAGAAGTTAATTCTCTGCATGAAAGATCTGA
AAACTGTGGTTTTAAAAATTCACAACCATTACCTTGTGAACGGAAGGATGTTCTCTGTGGAAAATTAGCTTGTGTTCAGCCACATAAAAA
TGCTAATAAAAGTGACGCTCAATCTACAGTTTATTCATATATTCAAGACCATGTATGTGTATCTATAGCCACTGGTTCCTCCATGAGATC
AGATGGAACAGACAATGCCTATGTGGCTGATGGCACCATGTGTGGTCCAGAAATGTACTGTGTAAATAAAACCTGCAGAAAAGTTCATTT
AATGGGATATAACTGTAATGCCACCACAAAATGCAAAGGGAAAGGGATATGTAATAATTTTGGTAATTGTCAATGCTTCCCTGGACATAG
ACCTCCAGATTGTAAATTCCAGTTTGGTTCCCCAGGGGGTAGTATTGATGATGGAAATTTTCAGAAATCTGGTGACTTTTATACTGAAAA
AGGCTACAATACACACTGGAACAACTGGTTTATTCTGAGTTTCTGCATTTTTCTGCCGTTTTTCATAGTTTTCACCACTGTGATCTTTAA
AAGAAATGAAATAAGTAAATCATGTAACAGAGAGAATGCAGAGTATAATCGTAATTCATCCGTTGTATCAGAAAGCGATGACGTGGGACA
TTAATATTGCACAGAACTTCCATAGCAAATAACCTAAAGGAACGAATGTGCTTTATTTATAACCTTACGTTATCCCCAATGCATTGTAAA

>30238_30238_2_FGFR1-ADAM18_FGFR1_chr8_38314874_ENST00000397103_ADAM18_chr8_39463826_ENST00000379866_length(amino acids)=703AA_BP=79
MGCGAGSASSSGLCWSQPHSAPLGRPRPCLNKMIYIITIDGQPYTLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFP
NSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIV
EKALMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYPD
AIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNG
ILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG
TAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDH
VCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDD

--------------------------------------------------------------
>30238_30238_3_FGFR1-ADAM18_FGFR1_chr8_38314874_ENST00000397103_ADAM18_chr8_39463826_ENST00000520772_length(transcript)=1407nt_BP=148nt
GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT
GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGATTTACATCATTACAATTGATGGACAACC
TTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATACATATAATGAAACTGGATCTTTGCATTCTGTGTC
TCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTCATTTGTGACACTCAGTATATGTTCTGGTCTCAG
GGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGCAAGATTTGAGCATATAATTTATCAAATGAAAAA
TAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGACCAGCCCTACAAAGTTCCTTTAAACTCACAGGT
GACTGTCATCATTCTGATGTTATGACATACTAGAACATTGCCTGTGTAGTTTTCTTGTAAATCATGAAAGGAATTTAGTTAGCTGTTGAG
TAGGAATATTAAATTTTATGTATTTTTCTACCTTTAAATAAAACATTGAAACTTCATCTAAAATATTTGGAAAGTTACATATTTCAAGCT
TAATATTTTATGATGTATTATGTAACATTAATTTTTATATTTTTTTCAAACAAAATGATACTATTGAAAAAGTTTAGAAATGCAGAAAGA
ACAGAGTCACTGTTATTCTAGTACCTTGGTAAAATTACTTTTAATATTTTGTTATATATCTTACATACTACCTGAACATATCTTTCTAAA
ATGCACAGCCATTTGCATGTTGCCAGATGCTCTTAATTTGCTGGTAGACTAGGTATAGAATTCTTGCTGGCAGTTTCTTTCTTTCAGCAC
TTTGAATATTTCAATCCATCACCATGTGGCCTCTGTTTTTTCTGATAAAAATATTCTATTATTCTTATTGGGAATTCCTTGGACAAAATG
AGTTGCTTCTCTTTTGTTTCTTTTGAGATTCTTCCTTTGCCTTTGTCTTATGGCAGTGTGCTTATCATGTTTCTATGAATGGATCTCTTT
GTGTTTACCATACTTGGAGCTCAAAGCACTTCTTGGGTCTGTAAATGGATGTGTTTTGAAATTAAATTAGCTTGTGTGAATCCTGAAAAA
AAAAATCCCATGAAGCTATGAAACCAACTATCTGTATGGTTCCTAGAGACTTCACACTTTTATTCTACTTTAAAATTTGTCTCGATTTTG

>30238_30238_3_FGFR1-ADAM18_FGFR1_chr8_38314874_ENST00000397103_ADAM18_chr8_39463826_ENST00000520772_length(amino acids)=170AA_BP=32
MGCGAGSASSSGLCWSQPHSAPLGRPRPCLNKMIYIITIDGQPYTLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FGFR1-ADAM18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR1-ADAM18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGFR1-ADAM18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource