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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR1-GPR124 (FusionGDB2 ID:30243)

Fusion Gene Summary for FGFR1-GPR124

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR1-GPR124
Fusion gene ID: 30243
HgeneTgene
Gene symbol

FGFR1

GPR124

Gene ID

2260

25960

Gene namefibroblast growth factor receptor 1adhesion G protein-coupled receptor A2
SynonymsBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1GPR124|TEM5
Cytomap

8p11.23

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgradhesion G protein-coupled receptor A2G-protein coupled receptor 124tumor endothelial marker 5
Modification date2020032920200313
UniProtAcc

P11362

.
Ensembl transtripts involved in fusion geneENST00000335922, ENST00000326324, 
ENST00000341462, ENST00000356207, 
ENST00000397091, ENST00000397103, 
ENST00000397113, ENST00000447712, 
ENST00000532791, ENST00000397108, 
ENST00000425967, ENST00000496629, 
ENST00000315215, ENST00000412232, 
Fusion gene scores* DoF score17 X 24 X 9=36725 X 2 X 4=40
# samples 205
** MAII scorelog2(20/3672*10)=-4.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FGFR1 [Title/Abstract] AND GPR124 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR1(38314874)-GPR124(37672414), # samples:1
Anticipated loss of major functional domain due to fusion event.FGFR1-GPR124 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR1-GPR124 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR1-GPR124 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

HgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

HgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

HgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

HgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851

TgeneGPR124

GO:0090263

positive regulation of canonical Wnt signaling pathway

30026314


check buttonFusion gene breakpoints across FGFR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPR124 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0EI-01AFGFR1chr8

38314874

-GPR124chr8

37672414

+


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Fusion Gene ORF analysis for FGFR1-GPR124

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000335922ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
5UTR-3CDSENST00000335922ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000326324ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000326324ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000341462ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000341462ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000356207ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000356207ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000397091ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000397091ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000397103ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000397103ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000397113ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000397113ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000447712ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000447712ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000532791ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
Frame-shiftENST00000532791ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
In-frameENST00000397108ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
In-frameENST00000397108ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
In-frameENST00000425967ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
In-frameENST00000425967ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+
intron-3CDSENST00000496629ENST00000315215FGFR1chr8

38314874

-GPR124chr8

37672414

+
intron-3CDSENST00000496629ENST00000412232FGFR1chr8

38314874

-GPR124chr8

37672414

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425967FGFR1chr838314874-ENST00000315215GPR124chr837672414+615451351736121031
ENST00000425967FGFR1chr838314874-ENST00000412232GPR124chr837672414+588551351742631248
ENST00000397108FGFR1chr838314874-ENST00000315215GPR124chr837672414+603339239634911031
ENST00000397108FGFR1chr838314874-ENST00000412232GPR124chr837672414+576439239641421248

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425967ENST00000315215FGFR1chr838314874-GPR124chr837672414+0.0117576290.9882423
ENST00000425967ENST00000412232FGFR1chr838314874-GPR124chr837672414+0.0182350050.98176503
ENST00000397108ENST00000315215FGFR1chr838314874-GPR124chr837672414+0.0119817290.9880183
ENST00000397108ENST00000412232FGFR1chr838314874-GPR124chr837672414+0.0162548370.9837451

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Fusion Genomic Features for FGFR1-GPR124


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGFR1chr838314873-GPR124chr837672413+2.46E-070.99999976
FGFR1chr838314873-GPR124chr837672413+2.46E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGFR1-GPR124


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38314874/chr8:37672414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR1

P11362

.
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016190_240881122.0DomainLRRCT
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016247_344881122.0DomainIg-like
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016707_758881122.0DomainGPS
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019190_240881339.0DomainLRRCT
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019247_344881339.0DomainIg-like
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019707_758881339.0DomainGPS
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016362_364881122.0MotifRGD
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019362_364881339.0MotifRGD
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016107_130881122.0RepeatLRR 2
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016131_154881122.0RepeatLRR 3
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016156_178881122.0RepeatLRR 4
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019107_130881339.0RepeatLRR 2
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019131_154881339.0RepeatLRR 3
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019156_178881339.0RepeatLRR 4
TgeneGPR124chr8:38314874chr8:37672414ENST000003152150161041_1047881122.0Topological domainExtracellular
TgeneGPR124chr8:38314874chr8:37672414ENST000003152150161069_1338881122.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016793_807881122.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016829_832881122.0Topological domainExtracellular
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016854_886881122.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016908_924881122.0Topological domainExtracellular
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016946_1019881122.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST000004122320191041_1047881339.0Topological domainExtracellular
TgeneGPR124chr8:38314874chr8:37672414ENST000004122320191069_1338881339.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019793_807881339.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019829_832881339.0Topological domainExtracellular
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019854_886881339.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019908_924881339.0Topological domainExtracellular
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019946_1019881339.0Topological domainCytoplasmic
TgeneGPR124chr8:38314874chr8:37672414ENST000003152150161020_1040881122.0TransmembraneHelical%3B Name%3D6
TgeneGPR124chr8:38314874chr8:37672414ENST000003152150161048_1068881122.0TransmembraneHelical%3B Name%3D7
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016772_792881122.0TransmembraneHelical%3B Name%3D1
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016808_828881122.0TransmembraneHelical%3B Name%3D2
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016833_853881122.0TransmembraneHelical%3B Name%3D3
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016887_907881122.0TransmembraneHelical%3B Name%3D4
TgeneGPR124chr8:38314874chr8:37672414ENST00000315215016925_945881122.0TransmembraneHelical%3B Name%3D5
TgeneGPR124chr8:38314874chr8:37672414ENST000004122320191020_1040881339.0TransmembraneHelical%3B Name%3D6
TgeneGPR124chr8:38314874chr8:37672414ENST000004122320191048_1068881339.0TransmembraneHelical%3B Name%3D7
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019772_792881339.0TransmembraneHelical%3B Name%3D1
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019808_828881339.0TransmembraneHelical%3B Name%3D2
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019833_853881339.0TransmembraneHelical%3B Name%3D3
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019887_907881339.0TransmembraneHelical%3B Name%3D4
TgeneGPR124chr8:38314874chr8:37672414ENST00000412232019925_945881339.0TransmembraneHelical%3B Name%3D5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217158_24630732.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217255_35730732.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-21725_11930732.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217478_76730732.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219158_2460813.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219255_3570813.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-21925_1190813.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219478_7670813.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217158_24630734.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217255_35730734.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-21725_11930734.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217478_76730734.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-21825_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-31925_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-21825_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319158_24663854.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319255_35763854.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-31925_11963854.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319478_76763854.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218158_24630823.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218255_35730823.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-21825_11930823.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218478_76730823.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218158_24630821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218255_35730821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-21825_11930821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218478_76730821.0DomainProtein kinase
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217484_49030732.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217562_56430732.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219484_4900813.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219562_5640813.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217484_49030734.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217562_56430734.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319484_49063854.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319562_56463854.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218484_49030823.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218562_56430823.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218484_49030821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218562_56430821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217160_17730732.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219160_1770813.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217160_17730734.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319160_17763854.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218160_17730823.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218160_17730821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-21722_37630732.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217398_82230732.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-21922_3760813.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219398_8220813.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-21722_37630734.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217398_82230734.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-21822_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-31922_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-21822_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-31922_37663854.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319398_82263854.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-21822_37630823.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218398_82230823.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-21822_37630821.0Topological domainExtracellular
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218398_82230821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38314874chr8:37672414ENST00000326324-217377_39730732.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000335922-219377_3970813.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000356207-217377_39730734.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397091-218377_39730821.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397108-319377_39730821.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000397113-218377_39730821.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000425967-319377_39763854.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000447712-218377_39730823.0TransmembraneHelical
HgeneFGFR1chr8:38314874chr8:37672414ENST00000532791-218377_39730821.0TransmembraneHelical
TgeneGPR124chr8:38314874chr8:37672414ENST0000031521501682_106881122.0RepeatLRR 1
TgeneGPR124chr8:38314874chr8:37672414ENST0000041223201982_106881339.0RepeatLRR 1
TgeneGPR124chr8:38314874chr8:37672414ENST0000031521501634_771881122.0Topological domainExtracellular
TgeneGPR124chr8:38314874chr8:37672414ENST0000041223201934_771881339.0Topological domainExtracellular


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Fusion Gene Sequence for FGFR1-GPR124


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30243_30243_1_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000397108_GPR124_chr8_37672414_ENST00000315215_length(transcript)=6033nt_BP=392nt
AACTTTTCCTCCAACTCGCGCTCGGGAGCTGGCGAGGCGGCGGCGGCTCCTCAAAGTGGGAGAGCTTCAAGGTCACGTGGTCCGTCCAGC
CCCTGCTATCTCACCAGACACTGTCCACCCTGTATGTTGGATCAGTACTCCAGTGAGAAGACAGCAGGCACTTTCACCCATGCAGCCCAT
TCAGTCTTCATAACCACCTGTGATGGAGGCAAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGC
CTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCAC
CGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGCTCTTGAGCAATAACAAGATCACGGGGCTCCGCAATGGCTCCTTCCTGGGACTGTCA
CTGCTGGAGAAGCTGGACCTGAGGAACAACATCATCAGCACAGTGCAGCCGGGCGCCTTCCTGGGCCTGGGGGAGCTGAAGCGTTTAGAT
CTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCTTCTCCGACTAAACATATCTGGAAACATCTTC
TCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGGCACCGAGTTCCTGACCTGTGACTGCCACCTG
CGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTGTGCTTACCCCAGTGCCCTGCATGCTCAGGCC
CTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACACCACCTCATCCCGTCCCTACGCCAAGTGGTG
TTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCGCATCCGCTGGTACCACAACCGAGCCCCTGTG
GAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTTCATCACCAGTGAGCTGACGCTGTCTCACATC
GGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAGCAAGAAGGTGGAGATCGTGGTGCTGGAGACC
TCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGGGACTTCAGGTGGCCCCGAACTCTGGCTGGCATCACAGCCTACCAG
TCCTGCCTGCAGTATCCCTTCACCTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGC
TGGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTACACCTTCGTGCTGATGCCCATCAATGCCTCC
AATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGCCGCTAGCTTTTCAGACATGATGGATGTAGTCTATGTGGCTCAG
ATGATCCAGAAATTTTTGGGTTATGTCGACCAGATCAAAGAGCTGGTAGAGGTGATGGTGGACATGGCCAGCAACCTGATGCTGGTGGAC
GAGCACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCCTGGAGCGCATTGGGGGGGCCGCCCTCAGC
CCCCATGCCCAGCACATCTCAGTGGAGCTGAGCGCCTTTCCCAGGGAGGTGGGGGGCGCCGGGGCAGGGCTGCACCCCGTGGTATACCCC
TGCACGGCCTTGCTGCTGCTCTGCCTCTTCGCCACCATCATCACCTACATCCTCAACCACAGCTCCATCCGTGTGTCCCGGAAAGGCTGG
CACATGCTGCTGAACTTGTGCTTCCACATAGCCATGACCTCTGCTGTCTTTGCGGGGGGCATCACACTCACCAACTACCAGATGGTCTGC
CAGGCGGTGGGCATCACCCTGCACTACTCCTCCCTATCCACGCTGCTCTGGATGGGCGTGAAGGCGCGAGTGCTCCATAAGGAGCTCACC
TGGAGGGCACCCCCTCCGCAAGAAGGGGACCCCGCTCTGCCTACTCCCAGTCCTATGCTCCGGTTCTATTTGATCGCTGGAGGGATTCCA
CTCATTATCTGTGGCATCACAGCTGCAGTCAACATCCACAACTACCGGGACCACAGCCCCTACTGCTGGCTGGTGTGGCGTCCAAGCCTT
GGCGCCTTCTACATCCCTGTGGCTTTGATTCTGCTCATCACCTGGATCTATTTCCTGTGCGCCGGGCTACGCTTACGGGGTCCTCTGGCA
CAGAACCCCAAGGCGGGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGGTTCCACCAGGCTCAGGGGCAGCGGCCCCCTC
CTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCGCGCGAGTGGGGACGCCCGGGCCCCCGGAGGATGGTGACAGCCTCTATTCTCCG
GGAGTCCAGCTAGGGGCGCTGGTGACCACGCACTTCCTGTACTTGGCCATGTGGGCCTGCGGGGCTCTGGCAGTGTCCCAGCGCTGGCTG
CCCCGGGTGGTGTGCAGCTGCTTGTACGGGGTGGCAGCCTCCGCCCTGGGCCTCTTCGTCTTCACTCACCACTGTGCCAGGCGGAGGGAC
GTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTCTCCCGCGGCCCCCCATGCCCCGCCCCGGGCCCTGCCCGCCGCCGCAGAGGAC
GGTTCCCCGGTGTTCGGGGAGGGCCCCCCCTCCCTCAAGTCCTCCCCAAGCGGCAGCAGCGGCCATCCGCTGGCTCTGGGCCCCTGCAAG
CTCACCAACCTGCAGCTGGCCCAGAGTCAGGTGTGCGAGGCGGGGGCGGCGGCCGGCGGGGAAGGAGAGCCGGAGCCGGCGGGCACCCGG
GGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCACGGGCGTCGGGCGCACAAGAGCCGGGCCAAGGGACACCGCGCGGGGGAGGCC
TGCGGCAAGAACCGGCTCAAGGCCCTGCGCGGGGGCGCGGCGGGGGCGCTGGAGCTGCTGTCCAGCGAGAGCGGCAGTCTGCACAACAGC
CCCACCGACAGCTACCTGGGCAGCAGCCGCAACAGCCCGGGCGCCGGCCTGCAGCTGGAAGGCGAGCCCATGCTCACGCCGTCCGAGGGC
AGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCGGGCAGGCCAGCGCCGCAGCGCCAGCCGCGACAGTCTCAAGGGCGGCGGCGCG
CTGGAGAAGGAGAGCCATCGCCGCTCGTACCCGCTCAACGCCGCCAGCCTAAACGGCGCCCCCAAGGGGGGCAAGTACGACGACGTCACC
CTGATGGGCGCGGAGGTAGCCAGCGGCGGCTGCATGAAGACCGGACTCTGGAAGAGCGAAACTACCGTCTAAGGTGGGGCGGGCGACGCG
GTAGACGGGCTGGCCACGCGGCTCGTTCCCCCGCTCCTCGGGGCCCTCCAAGGTGTCTCCGTAGTCAGCAGGTTGGAGGCAGAGGAGCCG
ATGGCTGGAGGAAGCCCACAGGCGGATGTTCCCCACTTGCCTAGAGGGCATCCCTCTGGGGTAGCGACAGACAATCCCAGAAACACGCAT
AATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCGGTGCCCTCCCAGGAACGGGGAAGGCCTCCGTCTGTGTGAAAGGGCACAGCAC
ATCCCAGGTGCACCCTCCCCAAGTACTCCCACCCCGCCTACTGTCCATGCGGCCTCACTGGGGGCCATCAGCCTCACCAGCAAAGCAGAG
ATGAGAGCGTGGGAACTGTGTTCTTTCCTCCCTGCCCTCTACTGATTTCAGCCCAGCCCCTGCCTAGATCCTAGGTCCCTTTTCCTCCCG
AGTTTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGCAGGTGATGTTAAGTCACAAGGTGCTGCTTTTCAGATCCACTATGCAAGAGGG
GAGGGTGGGGCCACGTGAAAGGCAGCTCTAGACATCAACCAGTCCTGGGGGAGGGGAGTGGGAACCGGGCACAACTAGGAACAATGCCAC
CATTCCCACAGGAGTGGTACTTAAACCAGACAGCAGGGTTCAGAGGTGGCACACCGGGACAAAGCTGAGGCCCTGCACCTCAACAGCTGA
CTGCCAGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGGGAGAGGGCAGGTGGAACTGGGGCAGAATCTAGTCATGCCCTAAAGCTAGTCC
TGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTTTGGAGAAGCAGTTACTTTTCAGTTACAAGACCCATCTCCCTAGTCTCAGCCT
TACAACACCACGGGACTAAGGAAGAGCACTTCCTTGCCTCCGTAAGGCCAGAGGAAGAACCATCCCAATCATTTGATCTCCAGCTCCACA
GTAGAGAGAAACCTACAAAATGTCAAACCAGCTTCCCGACTCCCAGGAGCTCAAGCCAAGCCCAGAGGCAGTGGCTGGGGTCCCTGCAGG
TCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCAGCACCCGTCTTTTCCCCAACCTAAAACCAACCACCAGCATTTCACTACAGGA
CCAAATGGAAACCGAGGGAACCCTGGGTCTTGGGAAGAACAACAGGAAACCAAGGTCTGACCTAGGGTTCCCTCCCAGTCTTCACATCAC
TCTGGCCTCATCACCAAGGTGACAGAGGACACAGGGGAGGGGGAAAACCCACACACACTCCTTGGAATGGGTCCTGTTATTTATGCTTGC
TGCACAGACATATTAGAAGAAAAAAAAAAGCTTTGTATTATTCTTCCACATATGCTGGCTGCTGTTTACACACCCTGCCAATGCCTTAGC
ACTGGAGAGCTTTTTGCAATATGCTGGGGAAAGGGGAGGGAGGGAATGAAAGTGCCAAAGAAAACATGTTTTTAAGAACTCGGGTTTTAT
ACAATAGAATGTTTTCTAGCAGATGCCTCTTGTTTTAATATATTAAAATTTTGCAAAGCCCTTTGAGCTACTGCCTTAGTCTACCCACTG
TCCTTTTGTTATGAGGTAGAGGATCTCATGACACCATACACACAAACCCATCATTGCCTGTGAATGCACGTAGGGCCAGAATTCCCCAGT
TCCCGCTCCTCTGAGGGTTGATACTGCTGGGAATGCCAACCACTCCACAAGCAGAGGGAAGCCCCCTCAGGCCTGCAGGAGGAGCCGCAG
CAGTGTGTCCAATTCAAACCAGCAGCAAAGAGCCTGACATTTTCCCATCCATCTATGAGGAAAGCCATCTCACAGAACATGGACATAGGC
AACTTGCTCTCCCACACCAAGGGATGGGAATCTCTCCTACCTATAGTCATCCCTGCACTCCTGACTTTACTCCAGGACCCAGGGTCCAAC
TAATGGCAGAGCCCCTCTTGGTTCCTTCAAACAAGAAAAGCAATACCTACGGACTGGTGTACACTTCCATCCTTGGTTATAACAGGAATG
TTATCAAGCTGTCAGAACAGGATGAAGTGCTCCCAGTGGATATCCATCAGGGAGGGTTAGGGACACTCGTGGCAGCCTGTCTAGCAGCCT
GGGCTCTCTGAAAGTCCCTAACTTCCTGAGGGGTACGCAAATACTGTTCTATTTCACTATCAGAAATGTTCTCATCTCCAGTGACAGTGG
AGACAGGGGGTACAGGGCAGATCCGCTTCGGGGACTTCAACATGCAGGGTGGCAAGAGAAGGGCAGGACTGGCCGGCCGCTTCCCCTGGG
GTAAACCTAAGGAATTATTTCCCACCTCCCCTTCTCCTTGCCCCTGTCCCCACCCCGGTGGCTCCTTCTCTCGGGTCTCCACTTCTGCTG
TCCCATCCCGAAAGGCAGAGCGGACCAGTGACTGGCGGTGCTGGAGAAGGTCACCGATGTGCTTCACCACAGACCGTTTGTCAAGTCTCA

>30243_30243_1_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000397108_GPR124_chr8_37672414_ENST00000315215_length(amino acids)=1031AA_BP=1
MSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELP
ALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSA
SYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVAN
NRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVY
TAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVELSA
FPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSL
STLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILL
ITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHF
LYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSL
KSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGG
AAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPL

--------------------------------------------------------------
>30243_30243_2_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000397108_GPR124_chr8_37672414_ENST00000412232_length(transcript)=5764nt_BP=392nt
AACTTTTCCTCCAACTCGCGCTCGGGAGCTGGCGAGGCGGCGGCGGCTCCTCAAAGTGGGAGAGCTTCAAGGTCACGTGGTCCGTCCAGC
CCCTGCTATCTCACCAGACACTGTCCACCCTGTATGTTGGATCAGTACTCCAGTGAGAAGACAGCAGGCACTTTCACCCATGCAGCCCAT
TCAGTCTTCATAACCACCTGTGATGGAGGCAAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCCATGGAGATGTGGAGC
CTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCAC
CGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGCTCTTGAGCAATAACAAGATCACGGGGCTCCGCAATGGCTCCTTCCTGGGACTGTCA
CTGCTGGAGAAGCTGGACCTGAGGAACAACATCATCAGCACAGTGCAGCCGGGCGCCTTCCTGGGCCTGGGGGAGCTGAAGCGTTTAGAT
CTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCTTCTCCGACTAAACATATCTGGAAACATCTTC
TCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGGCACCGAGTTCCTGACCTGTGACTGCCACCTG
CGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTGTGCTTACCCCAGTGCCCTGCATGCTCAGGCC
CTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACACCACCTCATCCCGTCCCTACGCCAAGTGGTG
TTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCGCATCCGCTGGTACCACAACCGAGCCCCTGTG
GAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTTCATCACCAGTGAGCTGACGCTGTCTCACATC
GGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAGCAAGAAGGTGGAGATCGTGGTGCTGGAGACC
TCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGGGACTTCAGGTGGCCCCGAACTCTGGCTGGCATCACAGCCTACCAG
TCCTGCCTGCAGTATCCCTTCACCTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGC
TGGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTACACCTTCGTGCTGATGCCCATCAATGCCTCC
AATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGCCGCTAGCTTTTCAGACATGATGGATGTAGTCTATGTGGCTCAG
ATGATCCAGAAATTTTTGGGTTATGTCGACCAGATCAAAGAGCTGGTAGAGGTGATGGTGGACATGGCCAGCAACCTGATGCTGGTGGAC
GAGCACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCCTGGAGCGCATTGGGGGGGCCGCCCTCAGC
CCCCATGCCCAGCACATCTCAGTGAATGCGAGGAACGTGGCATTGGAGGCCTACCTCATCAAGCCGCACAGCTACGTGGGCCTGACCTGC
ACAGCCTTCCAGAGGAGGGAGGGAGGGGTGCCGGGCACACGGCCAGGAAGCCCTGGCCAGAACCCCCCACCTGAGCCCGAGCCCCCAGCT
GACCAGCAGCTCCGCTTCCGCTGCACCACCGGGAGGCCCAATGTTTCTCTGTCGTCCTTCCACATCAAGAACAGCGTGGCCCTGGCCTCC
ATCCAGCTGCCCCCGAGTCTATTCTCATCCCTTCCGGCTGCCCTGGCTCCCCCGGTGCCCCCAGACTGCACCCTGCAACTGCTCGTCTTC
CGAAATGGCCGCCTCTTCCACAGCCACAGCAACACCTCCCGCCCTGGAGCTGCTGGGCCTGGCAAGAGGCGTGGCGTGGCCACCCCCGTC
ATCTTCGCAGGAACCAGTGGCTGTGGCGTGGGAAACCTGACAGAGCCAGTGGCCGTTTCGCTGCGGCACTGGGCTGAGGGAGCCGAACCT
GTGGCCGCTTGGTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGCTGGACCTCGGAGGGCTGCCAGCTCCGCTCCAGCCAGCCCAATGTC
AGCGCCCTGCACTGCCAGCACTTGGGCAATGTGGCCGTGCTCATGGAGCTGAGCGCCTTTCCCAGGGAGGTGGGGGGCGCCGGGGCAGGG
CTGCACCCCGTGGTATACCCCTGCACGGCCTTGCTGCTGCTCTGCCTCTTCGCCACCATCATCACCTACATCCTCAACCACAGCTCCATC
CGTGTGTCCCGGAAAGGCTGGCACATGCTGCTGAACTTGTGCTTCCACATAGCCATGACCTCTGCTGTCTTTGCGGGGGGCATCACACTC
ACCAACTACCAGATGGTCTGCCAGGCGGTGGGCATCACCCTGCACTACTCCTCCCTATCCACGCTGCTCTGGATGGGCGTGAAGGCGCGA
GTGCTCCATAAGGAGCTCACCTGGAGGGCACCCCCTCCGCAAGAAGGGGACCCCGCTCTGCCTACTCCCAGTCCTATGCTCCGGTTCTAT
TTGATCGCTGGAGGGATTCCACTCATTATCTGTGGCATCACAGCTGCAGTCAACATCCACAACTACCGGGACCACAGCCCCTACTGCTGG
CTGGTGTGGCGTCCAAGCCTTGGCGCCTTCTACATCCCTGTGGCTTTGATTCTGCTCATCACCTGGATCTATTTCCTGTGCGCCGGGCTA
CGCTTACGGGGTCCTCTGGCACAGAACCCCAAGGCGGGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGGTTCCACCAGG
CTCAGGGGCAGCGGCCCCCTCCTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCGCGCGAGTGGGGACGCCCGGGCCCCCGGAGGAT
GGTGACAGCCTCTATTCTCCGGGAGTCCAGCTAGGGGCGCTGGTGACCACGCACTTCCTGTACTTGGCCATGTGGGCCTGCGGGGCTCTG
GCAGTGTCCCAGCGCTGGCTGCCCCGGGTGGTGTGCAGCTGCTTGTACGGGGTGGCAGCCTCCGCCCTGGGCCTCTTCGTCTTCACTCAC
CACTGTGCCAGGCGGAGGGACGTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTCTCCCGCGGCCCCCCATGCCCCGCCCCGGGCC
CTGCCCGCCGCCGCAGAGGACGGTTCCCCGGTGTTCGGGGAGGGCCCCCCCTCCCTCAAGTCCTCCCCAAGCGGCAGCAGCGGCCATCCG
CTGGCTCTGGGCCCCTGCAAGCTCACCAACCTGCAGCTGGCCCAGAGTCAGGTGTGCGAGGCGGGGGCGGCGGCCGGCGGGGAAGGAGAG
CCGGAGCCGGCGGGCACCCGGGGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCACGGGCGTCGGGCGCACAAGAGCCGGGCCAAG
GGACACCGCGCGGGGGAGGCCTGCGGCAAGAACCGGCTCAAGGCCCTGCGCGGGGGCGCGGCGGGGGCGCTGGAGCTGCTGTCCAGCGAG
AGCGGCAGTCTGCACAACAGCCCCACCGACAGCTACCTGGGCAGCAGCCGCAACAGCCCGGGCGCCGGCCTGCAGCTGGAAGGCGAGCCC
ATGCTCACGCCGTCCGAGGGCAGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCGGGCAGGCCAGCGCCGCAGCGCCAGCCGCGAC
AGTCTCAAGGGCGGCGGCGCGCTGGAGAAGGAGAGCCATCGCCGCTCGTACCCGCTCAACGCCGCCAGCCTAAACGGCGCCCCCAAGGGG
GGCAAGTACGACGACGTCACCCTGATGGGCGCGGAGGTAGCCAGCGGCGGCTGCATGAAGACCGGACTCTGGAAGAGCGAAACTACCGTC
TAAGGTGGGGCGGGCGACGCGGTAGACGGGCTGGCCACGCGGCTCGTTCCCCCGCTCCTCGGGGCCCTCCAAGGTGTCTCCGTAGTCAGC
AGGTTGGAGGCAGAGGAGCCGATGGCTGGAGGAAGCCCACAGGCGGATGTTCCCCACTTGCCTAGAGGGCATCCCTCTGGGGTAGCGACA
GACAATCCCAGAAACACGCATAATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCGGTGCCCTCCCAGGAACGGGGAAGGCCTCCGT
CTGTGTGAAAGGGCACAGCACATCCCAGGTGCACCCTCCCCAAGTACTCCCACCCCGCCTACTGTCCATGCGGCCTCACTGGGGGCCATC
AGCCTCACCAGCAAAGCAGAGATGAGAGCGTGGGAACTGTGTTCTTTCCTCCCTGCCCTCTACTGATTTCAGCCCAGCCCCTGCCTAGAT
CCTAGGTCCCTTTTCCTCCCGAGTTTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGCAGGTGATGTTAAGTCACAAGGTGCTGCTTTT
CAGATCCACTATGCAAGAGGGGAGGGTGGGGCCACGTGAAAGGCAGCTCTAGACATCAACCAGTCCTGGGGGAGGGGAGTGGGAACCGGG
CACAACTAGGAACAATGCCACCATTCCCACAGGAGTGGTACTTAAACCAGACAGCAGGGTTCAGAGGTGGCACACCGGGACAAAGCTGAG
GCCCTGCACCTCAACAGCTGACTGCCAGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGGGAGAGGGCAGGTGGAACTGGGGCAGAATCTA
GTCATGCCCTAAAGCTAGTCCTGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTTTGGAGAAGCAGTTACTTTTCAGTTACAAGAC
CCATCTCCCTAGTCTCAGCCTTACAACACCACGGGACTAAGGAAGAGCACTTCCTTGCCTCCGTAAGGCCAGAGGAAGAACCATCCCAAT
CATTTGATCTCCAGCTCCACAGTAGAGAGAAACCTACAAAATGTCAAACCAGCTTCCCGACTCCCAGGAGCTCAAGCCAAGCCCAGAGGC
AGTGGCTGGGGTCCCTGCAGGTCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCAGCACCCGTCTTTTCCCCAACCTAAAACCAAC
CACCAGCATTTCACTACAGGACCAAATGGAAACCGAGGGAACCCTGGGTCTTGGGAAGAACAACAGGAAACCAAGGTCTGACCTAGGGTT
CCCTCCCAGTCTTCACATCACTCTGGCCTCATCACCAAGGTGACAGAGGACACAGGGGAGGGGGAAAACCCACACACACTCCTTGGAATG
GGTCCTGTTATTTATGCTTGCTGCACAGACATATTAGAAGAAAAAAAAAAGCTTTGTATTATTCTTCCACATATGCTGGCTGCTGTTTAC
ACACCCTGCCAATGCCTTAGCACTGGAGAGCTTTTTGCAATATGCTGGGGAAAGGGGAGGGAGGGAATGAAAGTGCCAAAGAAAACATGT
TTTTAAGAACTCGGGTTTTATACAATAGAATGTTTTCTAGCAGATGCCTCTTGTTTTAATATATTAAAATTTTGCAAAGCCCTTTGAGCT

>30243_30243_2_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000397108_GPR124_chr8_37672414_ENST00000412232_length(amino acids)=1248AA_BP=1
MSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELP
ALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSA
SYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVAN
NRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVY
TAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARN
VALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLP
AALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGE
AGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLN
LCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICG
ITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSG
SLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASW
RACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAH
RHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSA

--------------------------------------------------------------
>30243_30243_3_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000425967_GPR124_chr8_37672414_ENST00000315215_length(transcript)=6154nt_BP=513nt
CCCTTTCACCTCCTGGCTCCCTCCCGGGCGATCCGCGCCCCTTGGGTCTCCCCTCCCTTCCCTCCGTCCGCGTCTCCTGCGCCCCCTCCC
TGCGCTCGTCCCGCCGCTCTTCCCGCCGCCCAACTTTTCCTCCAACTCGCGCTCGGGAGCTGGCGAGGCGGCGGCGGCTCCTCAAAGTGG
GAGAGCTTCAAGGTCACGTGGTCCGTCCAGCCCCTGCTATCTCACCAGACACTGTCCACCCTGTATGTTGGATCAGTACTCCAGTGAGAA
GACAGCAGGCACTTTCACCCATGCAGCCCATTCAGTCTTCATAACCACCTGTGATGGAGGCAAGGGTCAGTTTGAAAAGGAGGATCGAGC
TCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCT
GGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGCTCTTGAGCAATAACAAGATCACGGG
GCTCCGCAATGGCTCCTTCCTGGGACTGTCACTGCTGGAGAAGCTGGACCTGAGGAACAACATCATCAGCACAGTGCAGCCGGGCGCCTT
CCTGGGCCTGGGGGAGCTGAAGCGTTTAGATCTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCT
TCTCCGACTAAACATATCTGGAAACATCTTCTCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGG
CACCGAGTTCCTGACCTGTGACTGCCACCTGCGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTG
TGCTTACCCCAGTGCCCTGCATGCTCAGGCCCTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACA
CCACCTCATCCCGTCCCTACGCCAAGTGGTGTTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCG
CATCCGCTGGTACCACAACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTT
CATCACCAGTGAGCTGACGCTGTCTCACATCGGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAG
CAAGAAGGTGGAGATCGTGGTGCTGGAGACCTCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGGGACTTCAGGTGGCC
CCGAACTCTGGCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTATCCCTTCACCTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCG
AGCCTCCCGCCGGTGTGACCGTGCCGGCCGCTGGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTA
CACCTTCGTGCTGATGCCCATCAATGCCTCCAATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGCCGCTAGCTTTTC
AGACATGATGGATGTAGTCTATGTGGCTCAGATGATCCAGAAATTTTTGGGTTATGTCGACCAGATCAAAGAGCTGGTAGAGGTGATGGT
GGACATGGCCAGCAACCTGATGCTGGTGGACGAGCACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGC
CCTGGAGCGCATTGGGGGGGCCGCCCTCAGCCCCCATGCCCAGCACATCTCAGTGGAGCTGAGCGCCTTTCCCAGGGAGGTGGGGGGCGC
CGGGGCAGGGCTGCACCCCGTGGTATACCCCTGCACGGCCTTGCTGCTGCTCTGCCTCTTCGCCACCATCATCACCTACATCCTCAACCA
CAGCTCCATCCGTGTGTCCCGGAAAGGCTGGCACATGCTGCTGAACTTGTGCTTCCACATAGCCATGACCTCTGCTGTCTTTGCGGGGGG
CATCACACTCACCAACTACCAGATGGTCTGCCAGGCGGTGGGCATCACCCTGCACTACTCCTCCCTATCCACGCTGCTCTGGATGGGCGT
GAAGGCGCGAGTGCTCCATAAGGAGCTCACCTGGAGGGCACCCCCTCCGCAAGAAGGGGACCCCGCTCTGCCTACTCCCAGTCCTATGCT
CCGGTTCTATTTGATCGCTGGAGGGATTCCACTCATTATCTGTGGCATCACAGCTGCAGTCAACATCCACAACTACCGGGACCACAGCCC
CTACTGCTGGCTGGTGTGGCGTCCAAGCCTTGGCGCCTTCTACATCCCTGTGGCTTTGATTCTGCTCATCACCTGGATCTATTTCCTGTG
CGCCGGGCTACGCTTACGGGGTCCTCTGGCACAGAACCCCAAGGCGGGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGG
TTCCACCAGGCTCAGGGGCAGCGGCCCCCTCCTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCGCGCGAGTGGGGACGCCCGGGCC
CCCGGAGGATGGTGACAGCCTCTATTCTCCGGGAGTCCAGCTAGGGGCGCTGGTGACCACGCACTTCCTGTACTTGGCCATGTGGGCCTG
CGGGGCTCTGGCAGTGTCCCAGCGCTGGCTGCCCCGGGTGGTGTGCAGCTGCTTGTACGGGGTGGCAGCCTCCGCCCTGGGCCTCTTCGT
CTTCACTCACCACTGTGCCAGGCGGAGGGACGTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTCTCCCGCGGCCCCCCATGCCCC
GCCCCGGGCCCTGCCCGCCGCCGCAGAGGACGGTTCCCCGGTGTTCGGGGAGGGCCCCCCCTCCCTCAAGTCCTCCCCAAGCGGCAGCAG
CGGCCATCCGCTGGCTCTGGGCCCCTGCAAGCTCACCAACCTGCAGCTGGCCCAGAGTCAGGTGTGCGAGGCGGGGGCGGCGGCCGGCGG
GGAAGGAGAGCCGGAGCCGGCGGGCACCCGGGGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCACGGGCGTCGGGCGCACAAGAG
CCGGGCCAAGGGACACCGCGCGGGGGAGGCCTGCGGCAAGAACCGGCTCAAGGCCCTGCGCGGGGGCGCGGCGGGGGCGCTGGAGCTGCT
GTCCAGCGAGAGCGGCAGTCTGCACAACAGCCCCACCGACAGCTACCTGGGCAGCAGCCGCAACAGCCCGGGCGCCGGCCTGCAGCTGGA
AGGCGAGCCCATGCTCACGCCGTCCGAGGGCAGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCGGGCAGGCCAGCGCCGCAGCGC
CAGCCGCGACAGTCTCAAGGGCGGCGGCGCGCTGGAGAAGGAGAGCCATCGCCGCTCGTACCCGCTCAACGCCGCCAGCCTAAACGGCGC
CCCCAAGGGGGGCAAGTACGACGACGTCACCCTGATGGGCGCGGAGGTAGCCAGCGGCGGCTGCATGAAGACCGGACTCTGGAAGAGCGA
AACTACCGTCTAAGGTGGGGCGGGCGACGCGGTAGACGGGCTGGCCACGCGGCTCGTTCCCCCGCTCCTCGGGGCCCTCCAAGGTGTCTC
CGTAGTCAGCAGGTTGGAGGCAGAGGAGCCGATGGCTGGAGGAAGCCCACAGGCGGATGTTCCCCACTTGCCTAGAGGGCATCCCTCTGG
GGTAGCGACAGACAATCCCAGAAACACGCATAATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCGGTGCCCTCCCAGGAACGGGGA
AGGCCTCCGTCTGTGTGAAAGGGCACAGCACATCCCAGGTGCACCCTCCCCAAGTACTCCCACCCCGCCTACTGTCCATGCGGCCTCACT
GGGGGCCATCAGCCTCACCAGCAAAGCAGAGATGAGAGCGTGGGAACTGTGTTCTTTCCTCCCTGCCCTCTACTGATTTCAGCCCAGCCC
CTGCCTAGATCCTAGGTCCCTTTTCCTCCCGAGTTTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGCAGGTGATGTTAAGTCACAAGG
TGCTGCTTTTCAGATCCACTATGCAAGAGGGGAGGGTGGGGCCACGTGAAAGGCAGCTCTAGACATCAACCAGTCCTGGGGGAGGGGAGT
GGGAACCGGGCACAACTAGGAACAATGCCACCATTCCCACAGGAGTGGTACTTAAACCAGACAGCAGGGTTCAGAGGTGGCACACCGGGA
CAAAGCTGAGGCCCTGCACCTCAACAGCTGACTGCCAGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGGGAGAGGGCAGGTGGAACTGGG
GCAGAATCTAGTCATGCCCTAAAGCTAGTCCTGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTTTGGAGAAGCAGTTACTTTTCA
GTTACAAGACCCATCTCCCTAGTCTCAGCCTTACAACACCACGGGACTAAGGAAGAGCACTTCCTTGCCTCCGTAAGGCCAGAGGAAGAA
CCATCCCAATCATTTGATCTCCAGCTCCACAGTAGAGAGAAACCTACAAAATGTCAAACCAGCTTCCCGACTCCCAGGAGCTCAAGCCAA
GCCCAGAGGCAGTGGCTGGGGTCCCTGCAGGTCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCAGCACCCGTCTTTTCCCCAACC
TAAAACCAACCACCAGCATTTCACTACAGGACCAAATGGAAACCGAGGGAACCCTGGGTCTTGGGAAGAACAACAGGAAACCAAGGTCTG
ACCTAGGGTTCCCTCCCAGTCTTCACATCACTCTGGCCTCATCACCAAGGTGACAGAGGACACAGGGGAGGGGGAAAACCCACACACACT
CCTTGGAATGGGTCCTGTTATTTATGCTTGCTGCACAGACATATTAGAAGAAAAAAAAAAGCTTTGTATTATTCTTCCACATATGCTGGC
TGCTGTTTACACACCCTGCCAATGCCTTAGCACTGGAGAGCTTTTTGCAATATGCTGGGGAAAGGGGAGGGAGGGAATGAAAGTGCCAAA
GAAAACATGTTTTTAAGAACTCGGGTTTTATACAATAGAATGTTTTCTAGCAGATGCCTCTTGTTTTAATATATTAAAATTTTGCAAAGC
CCTTTGAGCTACTGCCTTAGTCTACCCACTGTCCTTTTGTTATGAGGTAGAGGATCTCATGACACCATACACACAAACCCATCATTGCCT
GTGAATGCACGTAGGGCCAGAATTCCCCAGTTCCCGCTCCTCTGAGGGTTGATACTGCTGGGAATGCCAACCACTCCACAAGCAGAGGGA
AGCCCCCTCAGGCCTGCAGGAGGAGCCGCAGCAGTGTGTCCAATTCAAACCAGCAGCAAAGAGCCTGACATTTTCCCATCCATCTATGAG
GAAAGCCATCTCACAGAACATGGACATAGGCAACTTGCTCTCCCACACCAAGGGATGGGAATCTCTCCTACCTATAGTCATCCCTGCACT
CCTGACTTTACTCCAGGACCCAGGGTCCAACTAATGGCAGAGCCCCTCTTGGTTCCTTCAAACAAGAAAAGCAATACCTACGGACTGGTG
TACACTTCCATCCTTGGTTATAACAGGAATGTTATCAAGCTGTCAGAACAGGATGAAGTGCTCCCAGTGGATATCCATCAGGGAGGGTTA
GGGACACTCGTGGCAGCCTGTCTAGCAGCCTGGGCTCTCTGAAAGTCCCTAACTTCCTGAGGGGTACGCAAATACTGTTCTATTTCACTA
TCAGAAATGTTCTCATCTCCAGTGACAGTGGAGACAGGGGGTACAGGGCAGATCCGCTTCGGGGACTTCAACATGCAGGGTGGCAAGAGA
AGGGCAGGACTGGCCGGCCGCTTCCCCTGGGGTAAACCTAAGGAATTATTTCCCACCTCCCCTTCTCCTTGCCCCTGTCCCCACCCCGGT
GGCTCCTTCTCTCGGGTCTCCACTTCTGCTGTCCCATCCCGAAAGGCAGAGCGGACCAGTGACTGGCGGTGCTGGAGAAGGTCACCGATG

>30243_30243_3_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000425967_GPR124_chr8_37672414_ENST00000315215_length(amino acids)=1031AA_BP=1
MSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELP
ALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSA
SYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVAN
NRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVY
TAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVELSA
FPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSL
STLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILL
ITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHF
LYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSL
KSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGG
AAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPL

--------------------------------------------------------------
>30243_30243_4_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000425967_GPR124_chr8_37672414_ENST00000412232_length(transcript)=5885nt_BP=513nt
CCCTTTCACCTCCTGGCTCCCTCCCGGGCGATCCGCGCCCCTTGGGTCTCCCCTCCCTTCCCTCCGTCCGCGTCTCCTGCGCCCCCTCCC
TGCGCTCGTCCCGCCGCTCTTCCCGCCGCCCAACTTTTCCTCCAACTCGCGCTCGGGAGCTGGCGAGGCGGCGGCGGCTCCTCAAAGTGG
GAGAGCTTCAAGGTCACGTGGTCCGTCCAGCCCCTGCTATCTCACCAGACACTGTCCACCCTGTATGTTGGATCAGTACTCCAGTGAGAA
GACAGCAGGCACTTTCACCCATGCAGCCCATTCAGTCTTCATAACCACCTGTGATGGAGGCAAGGGTCAGTTTGAAAAGGAGGATCGAGC
TCACTGTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCT
GGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGCTCTTGAGCAATAACAAGATCACGGG
GCTCCGCAATGGCTCCTTCCTGGGACTGTCACTGCTGGAGAAGCTGGACCTGAGGAACAACATCATCAGCACAGTGCAGCCGGGCGCCTT
CCTGGGCCTGGGGGAGCTGAAGCGTTTAGATCTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCT
TCTCCGACTAAACATATCTGGAAACATCTTCTCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGG
CACCGAGTTCCTGACCTGTGACTGCCACCTGCGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTG
TGCTTACCCCAGTGCCCTGCATGCTCAGGCCCTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACA
CCACCTCATCCCGTCCCTACGCCAAGTGGTGTTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCG
CATCCGCTGGTACCACAACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTT
CATCACCAGTGAGCTGACGCTGTCTCACATCGGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAG
CAAGAAGGTGGAGATCGTGGTGCTGGAGACCTCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGGGACTTCAGGTGGCC
CCGAACTCTGGCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTATCCCTTCACCTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCG
AGCCTCCCGCCGGTGTGACCGTGCCGGCCGCTGGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTA
CACCTTCGTGCTGATGCCCATCAATGCCTCCAATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGCCGCTAGCTTTTC
AGACATGATGGATGTAGTCTATGTGGCTCAGATGATCCAGAAATTTTTGGGTTATGTCGACCAGATCAAAGAGCTGGTAGAGGTGATGGT
GGACATGGCCAGCAACCTGATGCTGGTGGACGAGCACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGC
CCTGGAGCGCATTGGGGGGGCCGCCCTCAGCCCCCATGCCCAGCACATCTCAGTGAATGCGAGGAACGTGGCATTGGAGGCCTACCTCAT
CAAGCCGCACAGCTACGTGGGCCTGACCTGCACAGCCTTCCAGAGGAGGGAGGGAGGGGTGCCGGGCACACGGCCAGGAAGCCCTGGCCA
GAACCCCCCACCTGAGCCCGAGCCCCCAGCTGACCAGCAGCTCCGCTTCCGCTGCACCACCGGGAGGCCCAATGTTTCTCTGTCGTCCTT
CCACATCAAGAACAGCGTGGCCCTGGCCTCCATCCAGCTGCCCCCGAGTCTATTCTCATCCCTTCCGGCTGCCCTGGCTCCCCCGGTGCC
CCCAGACTGCACCCTGCAACTGCTCGTCTTCCGAAATGGCCGCCTCTTCCACAGCCACAGCAACACCTCCCGCCCTGGAGCTGCTGGGCC
TGGCAAGAGGCGTGGCGTGGCCACCCCCGTCATCTTCGCAGGAACCAGTGGCTGTGGCGTGGGAAACCTGACAGAGCCAGTGGCCGTTTC
GCTGCGGCACTGGGCTGAGGGAGCCGAACCTGTGGCCGCTTGGTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGCTGGACCTCGGAGGG
CTGCCAGCTCCGCTCCAGCCAGCCCAATGTCAGCGCCCTGCACTGCCAGCACTTGGGCAATGTGGCCGTGCTCATGGAGCTGAGCGCCTT
TCCCAGGGAGGTGGGGGGCGCCGGGGCAGGGCTGCACCCCGTGGTATACCCCTGCACGGCCTTGCTGCTGCTCTGCCTCTTCGCCACCAT
CATCACCTACATCCTCAACCACAGCTCCATCCGTGTGTCCCGGAAAGGCTGGCACATGCTGCTGAACTTGTGCTTCCACATAGCCATGAC
CTCTGCTGTCTTTGCGGGGGGCATCACACTCACCAACTACCAGATGGTCTGCCAGGCGGTGGGCATCACCCTGCACTACTCCTCCCTATC
CACGCTGCTCTGGATGGGCGTGAAGGCGCGAGTGCTCCATAAGGAGCTCACCTGGAGGGCACCCCCTCCGCAAGAAGGGGACCCCGCTCT
GCCTACTCCCAGTCCTATGCTCCGGTTCTATTTGATCGCTGGAGGGATTCCACTCATTATCTGTGGCATCACAGCTGCAGTCAACATCCA
CAACTACCGGGACCACAGCCCCTACTGCTGGCTGGTGTGGCGTCCAAGCCTTGGCGCCTTCTACATCCCTGTGGCTTTGATTCTGCTCAT
CACCTGGATCTATTTCCTGTGCGCCGGGCTACGCTTACGGGGTCCTCTGGCACAGAACCCCAAGGCGGGCAACAGCAGGGCCTCCCTGGA
GGCAGGGGAGGAGCTGAGGGGTTCCACCAGGCTCAGGGGCAGCGGCCCCCTCCTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCGC
GCGAGTGGGGACGCCCGGGCCCCCGGAGGATGGTGACAGCCTCTATTCTCCGGGAGTCCAGCTAGGGGCGCTGGTGACCACGCACTTCCT
GTACTTGGCCATGTGGGCCTGCGGGGCTCTGGCAGTGTCCCAGCGCTGGCTGCCCCGGGTGGTGTGCAGCTGCTTGTACGGGGTGGCAGC
CTCCGCCCTGGGCCTCTTCGTCTTCACTCACCACTGTGCCAGGCGGAGGGACGTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTC
TCCCGCGGCCCCCCATGCCCCGCCCCGGGCCCTGCCCGCCGCCGCAGAGGACGGTTCCCCGGTGTTCGGGGAGGGCCCCCCCTCCCTCAA
GTCCTCCCCAAGCGGCAGCAGCGGCCATCCGCTGGCTCTGGGCCCCTGCAAGCTCACCAACCTGCAGCTGGCCCAGAGTCAGGTGTGCGA
GGCGGGGGCGGCGGCCGGCGGGGAAGGAGAGCCGGAGCCGGCGGGCACCCGGGGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCA
CGGGCGTCGGGCGCACAAGAGCCGGGCCAAGGGACACCGCGCGGGGGAGGCCTGCGGCAAGAACCGGCTCAAGGCCCTGCGCGGGGGCGC
GGCGGGGGCGCTGGAGCTGCTGTCCAGCGAGAGCGGCAGTCTGCACAACAGCCCCACCGACAGCTACCTGGGCAGCAGCCGCAACAGCCC
GGGCGCCGGCCTGCAGCTGGAAGGCGAGCCCATGCTCACGCCGTCCGAGGGCAGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCG
GGCAGGCCAGCGCCGCAGCGCCAGCCGCGACAGTCTCAAGGGCGGCGGCGCGCTGGAGAAGGAGAGCCATCGCCGCTCGTACCCGCTCAA
CGCCGCCAGCCTAAACGGCGCCCCCAAGGGGGGCAAGTACGACGACGTCACCCTGATGGGCGCGGAGGTAGCCAGCGGCGGCTGCATGAA
GACCGGACTCTGGAAGAGCGAAACTACCGTCTAAGGTGGGGCGGGCGACGCGGTAGACGGGCTGGCCACGCGGCTCGTTCCCCCGCTCCT
CGGGGCCCTCCAAGGTGTCTCCGTAGTCAGCAGGTTGGAGGCAGAGGAGCCGATGGCTGGAGGAAGCCCACAGGCGGATGTTCCCCACTT
GCCTAGAGGGCATCCCTCTGGGGTAGCGACAGACAATCCCAGAAACACGCATAATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCG
GTGCCCTCCCAGGAACGGGGAAGGCCTCCGTCTGTGTGAAAGGGCACAGCACATCCCAGGTGCACCCTCCCCAAGTACTCCCACCCCGCC
TACTGTCCATGCGGCCTCACTGGGGGCCATCAGCCTCACCAGCAAAGCAGAGATGAGAGCGTGGGAACTGTGTTCTTTCCTCCCTGCCCT
CTACTGATTTCAGCCCAGCCCCTGCCTAGATCCTAGGTCCCTTTTCCTCCCGAGTTTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGC
AGGTGATGTTAAGTCACAAGGTGCTGCTTTTCAGATCCACTATGCAAGAGGGGAGGGTGGGGCCACGTGAAAGGCAGCTCTAGACATCAA
CCAGTCCTGGGGGAGGGGAGTGGGAACCGGGCACAACTAGGAACAATGCCACCATTCCCACAGGAGTGGTACTTAAACCAGACAGCAGGG
TTCAGAGGTGGCACACCGGGACAAAGCTGAGGCCCTGCACCTCAACAGCTGACTGCCAGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGG
GAGAGGGCAGGTGGAACTGGGGCAGAATCTAGTCATGCCCTAAAGCTAGTCCTGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTT
TGGAGAAGCAGTTACTTTTCAGTTACAAGACCCATCTCCCTAGTCTCAGCCTTACAACACCACGGGACTAAGGAAGAGCACTTCCTTGCC
TCCGTAAGGCCAGAGGAAGAACCATCCCAATCATTTGATCTCCAGCTCCACAGTAGAGAGAAACCTACAAAATGTCAAACCAGCTTCCCG
ACTCCCAGGAGCTCAAGCCAAGCCCAGAGGCAGTGGCTGGGGTCCCTGCAGGTCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCA
GCACCCGTCTTTTCCCCAACCTAAAACCAACCACCAGCATTTCACTACAGGACCAAATGGAAACCGAGGGAACCCTGGGTCTTGGGAAGA
ACAACAGGAAACCAAGGTCTGACCTAGGGTTCCCTCCCAGTCTTCACATCACTCTGGCCTCATCACCAAGGTGACAGAGGACACAGGGGA
GGGGGAAAACCCACACACACTCCTTGGAATGGGTCCTGTTATTTATGCTTGCTGCACAGACATATTAGAAGAAAAAAAAAAGCTTTGTAT
TATTCTTCCACATATGCTGGCTGCTGTTTACACACCCTGCCAATGCCTTAGCACTGGAGAGCTTTTTGCAATATGCTGGGGAAAGGGGAG
GGAGGGAATGAAAGTGCCAAAGAAAACATGTTTTTAAGAACTCGGGTTTTATACAATAGAATGTTTTCTAGCAGATGCCTCTTGTTTTAA

>30243_30243_4_FGFR1-GPR124_FGFR1_chr8_38314874_ENST00000425967_GPR124_chr8_37672414_ENST00000412232_length(amino acids)=1248AA_BP=1
MSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELP
ALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSA
SYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVAN
NRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVY
TAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARN
VALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLP
AALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGE
AGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLN
LCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICG
ITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSG
SLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASW
RACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAH
RHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSA

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Fusion Gene PPI Analysis for FGFR1-GPR124


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR1-GPR124


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGFR1-GPR124


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource