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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR2-AHCYL1 (FusionGDB2 ID:30273)

Fusion Gene Summary for FGFR2-AHCYL1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2-AHCYL1
Fusion gene ID: 30273
HgeneTgene
Gene symbol

FGFR2

AHCYL1

Gene ID

2263

10768

Gene namefibroblast growth factor receptor 2adenosylhomocysteinase like 1
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25DCAL|IRBIT|PPP1R78|PRO0233|XPVKONA
Cytomap

10q26.13

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cell
Modification date2020032220200313
UniProtAcc

P21802

O43865

Ensembl transtripts involved in fusion geneENST00000346997, ENST00000351936, 
ENST00000356226, ENST00000357555, 
ENST00000358487, ENST00000360144, 
ENST00000369056, ENST00000369059, 
ENST00000369060, ENST00000369061, 
ENST00000457416, ENST00000478859, 
ENST00000359354, ENST00000490349, 
ENST00000475081, ENST00000359172, 
ENST00000393614, ENST00000369799, 
Fusion gene scores* DoF score24 X 20 X 12=576011 X 13 X 4=572
# samples 3812
** MAII scorelog2(38/5760*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/572*10)=-2.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR2 [Title/Abstract] AND AHCYL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR2(123243212)-AHCYL1(110551654), # samples:2
Anticipated loss of major functional domain due to fusion event.FGFR2-AHCYL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR2-AHCYL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR2-AHCYL1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
FGFR2-AHCYL1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FGFR2-AHCYL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FGFR2-AHCYL1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145

TgeneAHCYL1

GO:0006378

mRNA polyadenylation

19224921

TgeneAHCYL1

GO:0031440

regulation of mRNA 3'-end processing

19224921

TgeneAHCYL1

GO:0038166

angiotensin-activated signaling pathway

20584908

TgeneAHCYL1

GO:0051592

response to calcium ion

18829453


check buttonFusion gene breakpoints across FGFR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AHCYL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAB821309FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
ChiTaRS5.0N/ALP131425FGFR2chr10

123243212

-AHCYL1chr1

110551654

+


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Fusion Gene ORF analysis for FGFR2-AHCYL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000346997ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000351936ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000356226ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000357555ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000358487ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000360144ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000369056ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000369059ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000369060ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000369061ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000457416ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-3UTRENST00000478859ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000346997ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000346997ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000351936ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000351936ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000356226ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000356226ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000357555ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000357555ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000358487ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000358487ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000360144ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000360144ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369056ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369056ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369059ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369059ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369060ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369060ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369061ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000369061ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000457416ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000457416ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000478859ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
5CDS-5UTRENST00000478859ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000351936ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000356226ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000357555ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000358487ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000360144ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000369059ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000369060ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000457416ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
Frame-shiftENST00000478859ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
In-frameENST00000346997ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
In-frameENST00000369056ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
In-frameENST00000369061ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-3CDSENST00000359354ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-3CDSENST00000490349ENST00000369799FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-3UTRENST00000359354ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-3UTRENST00000490349ENST00000475081FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-5UTRENST00000359354ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-5UTRENST00000359354ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-5UTRENST00000490349ENST00000359172FGFR2chr10

123243212

-AHCYL1chr1

110551654

+
intron-5UTRENST00000490349ENST00000393614FGFR2chr10

123243212

-AHCYL1chr1

110551654

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369061FGFR2chr10123243212-ENST00000369799AHCYL1chr1110551654+564321154835871179
ENST00000346997FGFR2chr10123243212-ENST00000369799AHCYL1chr1110551654+583523071237791255
ENST00000369056FGFR2chr10123243212-ENST00000369799AHCYL1chr1110551654+585623282438001258

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369061ENST00000369799FGFR2chr10123243212-AHCYL1chr1110551654+0.0002585390.9997415
ENST00000346997ENST00000369799FGFR2chr10123243212-AHCYL1chr1110551654+0.0001999040.99980015
ENST00000369056ENST00000369799FGFR2chr10123243212-AHCYL1chr1110551654+0.0003525470.9996475

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Fusion Genomic Features for FGFR2-AHCYL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGFR2chr10123243211-AHCYL1chr1110551655+2.50E-060.9999975
FGFR2chr10123243211-AHCYL1chr1110551655+2.50E-060.9999975

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGFR2-AHCYL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123243212/chr1:110551654)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

AHCYL1

O43865

FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.FUNCTION: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617154_247765820.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617256_358765820.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-161725_125765820.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718154_247765786.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718256_358765786.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-171825_125765786.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516154_247650705.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516256_358650705.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-151625_125650705.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617154_247678708.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617256_358678708.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-161725_125678708.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718154_247767822.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718256_358767822.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-171825_125767822.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718481_770767822.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617154_247679681.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617256_358679681.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-161725_125679681.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617154_247768770.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617256_358768770.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-161725_125768770.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617481_770768770.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516154_247651706.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516256_358651706.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-151625_125651706.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415154_247655710.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415256_358655710.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-141525_125655710.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718154_247768823.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718256_358768823.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-171825_125768823.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718481_770768823.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617487_495765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617565_567765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718487_495765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718565_567765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516487_495650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516565_567650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617487_495678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617565_567678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718487_495767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718565_567767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617487_495679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617565_567679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617487_495768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617565_567768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516487_495651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516565_567651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415487_495655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415565_567655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718487_495768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718565_567768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617161_178765820.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718161_178765786.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516161_178650705.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617161_178678708.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718161_178767822.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617161_178679681.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617161_178768770.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516161_178651706.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415161_178655710.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718161_178768823.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-161722_377765820.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-171822_377765786.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-151622_377650705.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-161722_377678708.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-171822_377767822.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-161722_377679681.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-161722_377768770.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-151622_377651706.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-141522_377655710.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-171822_377768823.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617378_398765820.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718378_398765786.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516378_398650705.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617378_398678708.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718378_398767822.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617378_398679681.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617378_398768770.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516378_398651706.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415378_398655710.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718378_398768823.0TransmembraneHelical
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000359172017318_3220484.0Nucleotide bindingNAD
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000359172017397_3990484.0Nucleotide bindingNAD
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000369799017318_32240531.0Nucleotide bindingNAD
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000369799017397_39940531.0Nucleotide bindingNAD
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000393614017318_3220484.0Nucleotide bindingNAD
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000393614017397_3990484.0Nucleotide bindingNAD
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000359172017281_4480484.0RegionNAD binding
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000359172017520_5300484.0RegionPDZ-binding
TgeneAHCYL1chr10:123243212chr1:110551654ENST0000035917201765_920484.0RegionPEST
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000369799017281_44840531.0RegionNAD binding
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000369799017520_53040531.0RegionPDZ-binding
TgeneAHCYL1chr10:123243212chr1:110551654ENST0000036979901765_9240531.0RegionPEST
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000393614017281_4480484.0RegionNAD binding
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000393614017520_5300484.0RegionPDZ-binding
TgeneAHCYL1chr10:123243212chr1:110551654ENST0000039361401765_920484.0RegionPEST

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617481_770765820.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718481_770765786.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516481_770650705.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617481_770678708.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17154_2470255.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17256_3580255.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-1725_1250255.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17481_7700255.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617481_770679681.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516481_770651706.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415481_770655710.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17487_4950255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17565_5670255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17161_1780255.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr1:110551654ENST00000346997-1617399_821765820.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000351936-1718399_821765786.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000356226-1516399_821650705.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000357555-1617399_821678708.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000358487-1718399_821767822.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-1722_3770255.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17399_8210255.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000360144-1617399_821679681.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369056-1617399_821768770.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369060-1516399_821651706.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000369061-1415399_821655710.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000457416-1718399_821768823.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr1:110551654ENST00000359354-17378_3980255.0TransmembraneHelical


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Fusion Gene Sequence for FGFR2-AHCYL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30273_30273_1_FGFR2-AHCYL1_FGFR2_chr10_123243212_ENST00000346997_AHCYL1_chr1_110551654_ENST00000369799_length(transcript)=5835nt_BP=2307nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCA
GCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAA
AAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCC
TTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAA
GGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCA
ACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAATCCAGTTTGCTGATGACATGCAGGAGTTC
ACCAAATTCCCCACCAAAACTGGCCGAAGATCTTTGTCTCGCTCGATCTCACAGTCCTCCACTGACAGCTACAGTTCAGCTGCATCCTAC
ACAGATAGCTCTGATGATGAGGTTTCTCCCCGAGAGAAGCAGCAAACCAACTCCAAGGGCAGCAGCAATTTCTGTGTGAAGAACATCAAG
CAGGCAGAATTTGGACGCCGGGAGATTGAGATTGCAGAGCAAGACATGTCTGCTCTGATTTCACTCAGGAAACGTGCTCAGGGGGAGAAG
CCCTTGGCTGGTGCTAAAATAGTGGGCTGTACACACATCACAGCCCAGACAGCGGTGTTGATTGAGACACTCTGTGCCCTGGGGGCTCAG
TGCCGCTGGTCTGCTTGTAACATCTACTCAACTCAGAATGAAGTAGCTGCAGCACTGGCTGAGGCTGGAGTTGCAGTGTTCGCTTGGAAG
GGCGAGTCAGAAGATGACTTCTGGTGGTGTATTGACCGCTGTGTGAACATGGATGGGTGGCAGGCCAACATGATCCTGGATGATGGGGGA
GACTTAACCCACTGGGTTTATAAGAAGTATCCAAACGTGTTTAAGAAGATCCGAGGCATTGTGGAAGAGAGCGTGACTGGTGTTCACAGG
CTGTATCAGCTCTCCAAAGCTGGGAAGCTCTGTGTTCCGGCCATGAACGTCAATGATTCTGTTACCAAACAGAAGTTTGATAACTTGTAC
TGCTGCCGAGAATCCATTTTGGATGGCCTGAAGAGGACCACAGATGTGATGTTTGGTGGGAAACAAGTGGTGGTGTGTGGCTATGGTGAG
GTAGGCAAGGGCTGCTGTGCTGCTCTCAAAGCTCTTGGAGCAATTGTCTACATTACCGAAATCGACCCCATCTGTGCTCTGCAGGCCTGC
ATGGATGGGTTCAGGGTGGTAAAGCTAAATGAAGTCATCCGGCAAGTCGATGTCGTAATAACTTGCACAGGAAATAAGAATGTAGTGACA
CGGGAGCACTTGGATCGCATGAAAAACAGTTGTATCGTATGCAATATGGGCCACTCCAACACAGAAATCGATGTGACCAGCCTCCGCACT
CCGGAGCTGACGTGGGAGCGAGTACGTTCTCAGGTGGACCATGTCATCTGGCCAGATGGCAAACGAGTTGTCCTCCTGGCAGAGGGTCGT
CTACTCAATTTGAGCTGCTCCACAGTTCCCACCTTTGTTCTGTCCATCACAGCCACAACACAGGCTTTGGCACTGATAGAACTCTATAAT
GCACCCGAGGGGCGATACAAGCAGGATGTGTACTTGCTTCCTAAGAAAATGGATGAATACGTTGCCAGCTTGCATCTGCCATCATTTGAT
GCCCACCTTACAGAGCTGACAGATGACCAAGCAAAATATCTGGGACTCAACAAAAATGGGCCATTCAAACCTAATTATTACAGATACTAA
TGGACCATACTACCAAGGACCAGTCCACCTGAACCACACACTCTAAAGAAATATTTTTTAAGATAACTTTTATTTTCTTCTTACTCCTTT
CCTCTTGATTTTTTTCCTATAATTTCATTCTTGTTTTTTCATCTCATTATCCAAGTTCTGCAGACCACACAGGAACTTGCTTCATGGCTC
TTTAGATGAAATAGAAGTTCAGGGTTCCTCACTCTAGTCACTAAAGAAGGATTTTACTCTCCCAGCCCAGAAAGGTGATTCTTTCTTTAC
CATTTCTGGGGACTTTAGTCTTAATTAGGTACCTTATTAACAGGAAATGCTAAGGTACCTTCTCTGTGGAACAATCTGCAATGTCTAAAT
CGCCTTAAAAGAGCCCATTTCTTAGCTGCTGAAATCAGTGCTCTTTCACTTCTTCAGAGAAGCAGGGATGGTACCTACCCGGCAGGTAGG
TTAGATGTGGGTGGTGCATGTTAATTTCCCTTAGAAGTTCCAAGCCCTGTTTCCTGCGTAAAGGTGGTATGTCCAGTTCAGAGATGTGTA
TAATGAGCATGGCTTGTTAAGATCAGGAGGCCCACTTGGATTTATAGTATAGCCCTTCCTCCACTCCCACCAGACTTGCTCATTTTTCGA
GTTTTTAACTAGACTACACTCTATTGAGTTTAATTTTGTCCTCTAGGATTTATTTCTGTTGTCCAAAAAAAAAAAAAAAGAAAAGAAAAA
TTAAGGAGAATTTTTGGTGTTAATGCTGAGGAATTGCTTGAGTGGTTAGTTGTTACCAATTTCTCTTTTGAACCTTTGGAGCTAAGGATG
CTGAGTCTAGAGAAATGCTAGTCTCAAGCCCTGTTAAGTCCCTCTGTTTCTAGCCCGTAGTTCATAGCATCAGTGAACTGGAGCCACAAC
AGCAAATTCTATCAGCTGTGTACCATACAGCTTGTGCTGAAGGCGAATTTCTTGAGCCATTACTCAGTATAAAGCACTGAGTTCTATCTT
TAGGATTTATCTTTAAGAGCAAATTTCTGGTCAGCTGTGCTTCTGCAACCTAAAATATTTAAAGGGAGGTAGGTGTGGGCAGGAGGAGGA
ATGATAAATTGGGCCAGGGCAAGAAAAATCTAGCTTCATATAATTTGTCTGGGACTATACACCCTATATAATGTTAGTTTTACAGAAGTA
ATATGACTTTTGATTGCTACATACCACAAAGAGTTTATGAACTGAGATCATAAAGGGCAACTGATGTGTGAAGAAAGTAGTCAGTACATC
CTGGCTCATGCTCTGAAAGAATATCCAGAGAGGCTCTCTCAAAGATCAGGGAGATGTATTCCCATGCCATGCACCCTGCTTCCCAGCATT
TCTGCATGGTCAAGTGAGCTTTATGCTCATGAGCTTTAAGTATATAATTATCCAGGATTTTAAATCCTCAACTTGTTCTAGCTTGTGATC
CCTCAAAGTTGGGTCATACGTTAGTGCTAGATACTAGAAATTTTCACTTTTCCACTGATCAGAGAGACAGACATTAAAAACAAAAATAGA
AGAAAGGAAAGCTTTCACCCTGCAGCTTCTTAGCAGGGAACAATTGTCTTGCCAAAACTTTTTTCCCTTTTCTCTCCCATTTTCTTTTAC
CCAATCCCTTCTTACTCCTTGCCAGTGTGACCATGCTTTCTTCTCTGTAGATGTTAACAGTTAAGGCCTATTTTCCTCGGGCACTTAACC
AACCAATCAGAACACCACATCTGTTAGGGGAGGTAACCTGGCCAACAGTGTATCCATCACGTTAGCCCTGCTGGAGGGAAGGGACCCACA
TTCACCTGCCCTCTGACCTGCCCCTTGATCCCATATCTATTACCGTGTCCATAGGAATAATAGGTAAGGGCTCTGTCTCTGTCAAGCCAT
GTAACAAAGGACACTGTTAAAAAAAAAAAAAAGTCTGGCATCAGAGGGAGCATGTGGAGAGCAACTTGGGAAGAACAAGTTCATTTTGTA

>30273_30273_1_FGFR2-AHCYL1_FGFR2_chr10_123243212_ENST00000346997_AHCYL1_chr1_110551654_ENST00000369799_length(amino acids)=1255AA_BP=765
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQIQFADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSS
DDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWS
ACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQL
SKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGF
RVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNL

--------------------------------------------------------------
>30273_30273_2_FGFR2-AHCYL1_FGFR2_chr10_123243212_ENST00000369056_AHCYL1_chr1_110551654_ENST00000369799_length(transcript)=5856nt_BP=2328nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATC
AACAATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACT
CATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAA
CTTTTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCAT
GCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAATCCAGTTT
GCTGATGACATGCAGGAGTTCACCAAATTCCCCACCAAAACTGGCCGAAGATCTTTGTCTCGCTCGATCTCACAGTCCTCCACTGACAGC
TACAGTTCAGCTGCATCCTACACAGATAGCTCTGATGATGAGGTTTCTCCCCGAGAGAAGCAGCAAACCAACTCCAAGGGCAGCAGCAAT
TTCTGTGTGAAGAACATCAAGCAGGCAGAATTTGGACGCCGGGAGATTGAGATTGCAGAGCAAGACATGTCTGCTCTGATTTCACTCAGG
AAACGTGCTCAGGGGGAGAAGCCCTTGGCTGGTGCTAAAATAGTGGGCTGTACACACATCACAGCCCAGACAGCGGTGTTGATTGAGACA
CTCTGTGCCCTGGGGGCTCAGTGCCGCTGGTCTGCTTGTAACATCTACTCAACTCAGAATGAAGTAGCTGCAGCACTGGCTGAGGCTGGA
GTTGCAGTGTTCGCTTGGAAGGGCGAGTCAGAAGATGACTTCTGGTGGTGTATTGACCGCTGTGTGAACATGGATGGGTGGCAGGCCAAC
ATGATCCTGGATGATGGGGGAGACTTAACCCACTGGGTTTATAAGAAGTATCCAAACGTGTTTAAGAAGATCCGAGGCATTGTGGAAGAG
AGCGTGACTGGTGTTCACAGGCTGTATCAGCTCTCCAAAGCTGGGAAGCTCTGTGTTCCGGCCATGAACGTCAATGATTCTGTTACCAAA
CAGAAGTTTGATAACTTGTACTGCTGCCGAGAATCCATTTTGGATGGCCTGAAGAGGACCACAGATGTGATGTTTGGTGGGAAACAAGTG
GTGGTGTGTGGCTATGGTGAGGTAGGCAAGGGCTGCTGTGCTGCTCTCAAAGCTCTTGGAGCAATTGTCTACATTACCGAAATCGACCCC
ATCTGTGCTCTGCAGGCCTGCATGGATGGGTTCAGGGTGGTAAAGCTAAATGAAGTCATCCGGCAAGTCGATGTCGTAATAACTTGCACA
GGAAATAAGAATGTAGTGACACGGGAGCACTTGGATCGCATGAAAAACAGTTGTATCGTATGCAATATGGGCCACTCCAACACAGAAATC
GATGTGACCAGCCTCCGCACTCCGGAGCTGACGTGGGAGCGAGTACGTTCTCAGGTGGACCATGTCATCTGGCCAGATGGCAAACGAGTT
GTCCTCCTGGCAGAGGGTCGTCTACTCAATTTGAGCTGCTCCACAGTTCCCACCTTTGTTCTGTCCATCACAGCCACAACACAGGCTTTG
GCACTGATAGAACTCTATAATGCACCCGAGGGGCGATACAAGCAGGATGTGTACTTGCTTCCTAAGAAAATGGATGAATACGTTGCCAGC
TTGCATCTGCCATCATTTGATGCCCACCTTACAGAGCTGACAGATGACCAAGCAAAATATCTGGGACTCAACAAAAATGGGCCATTCAAA
CCTAATTATTACAGATACTAATGGACCATACTACCAAGGACCAGTCCACCTGAACCACACACTCTAAAGAAATATTTTTTAAGATAACTT
TTATTTTCTTCTTACTCCTTTCCTCTTGATTTTTTTCCTATAATTTCATTCTTGTTTTTTCATCTCATTATCCAAGTTCTGCAGACCACA
CAGGAACTTGCTTCATGGCTCTTTAGATGAAATAGAAGTTCAGGGTTCCTCACTCTAGTCACTAAAGAAGGATTTTACTCTCCCAGCCCA
GAAAGGTGATTCTTTCTTTACCATTTCTGGGGACTTTAGTCTTAATTAGGTACCTTATTAACAGGAAATGCTAAGGTACCTTCTCTGTGG
AACAATCTGCAATGTCTAAATCGCCTTAAAAGAGCCCATTTCTTAGCTGCTGAAATCAGTGCTCTTTCACTTCTTCAGAGAAGCAGGGAT
GGTACCTACCCGGCAGGTAGGTTAGATGTGGGTGGTGCATGTTAATTTCCCTTAGAAGTTCCAAGCCCTGTTTCCTGCGTAAAGGTGGTA
TGTCCAGTTCAGAGATGTGTATAATGAGCATGGCTTGTTAAGATCAGGAGGCCCACTTGGATTTATAGTATAGCCCTTCCTCCACTCCCA
CCAGACTTGCTCATTTTTCGAGTTTTTAACTAGACTACACTCTATTGAGTTTAATTTTGTCCTCTAGGATTTATTTCTGTTGTCCAAAAA
AAAAAAAAAAGAAAAGAAAAATTAAGGAGAATTTTTGGTGTTAATGCTGAGGAATTGCTTGAGTGGTTAGTTGTTACCAATTTCTCTTTT
GAACCTTTGGAGCTAAGGATGCTGAGTCTAGAGAAATGCTAGTCTCAAGCCCTGTTAAGTCCCTCTGTTTCTAGCCCGTAGTTCATAGCA
TCAGTGAACTGGAGCCACAACAGCAAATTCTATCAGCTGTGTACCATACAGCTTGTGCTGAAGGCGAATTTCTTGAGCCATTACTCAGTA
TAAAGCACTGAGTTCTATCTTTAGGATTTATCTTTAAGAGCAAATTTCTGGTCAGCTGTGCTTCTGCAACCTAAAATATTTAAAGGGAGG
TAGGTGTGGGCAGGAGGAGGAATGATAAATTGGGCCAGGGCAAGAAAAATCTAGCTTCATATAATTTGTCTGGGACTATACACCCTATAT
AATGTTAGTTTTACAGAAGTAATATGACTTTTGATTGCTACATACCACAAAGAGTTTATGAACTGAGATCATAAAGGGCAACTGATGTGT
GAAGAAAGTAGTCAGTACATCCTGGCTCATGCTCTGAAAGAATATCCAGAGAGGCTCTCTCAAAGATCAGGGAGATGTATTCCCATGCCA
TGCACCCTGCTTCCCAGCATTTCTGCATGGTCAAGTGAGCTTTATGCTCATGAGCTTTAAGTATATAATTATCCAGGATTTTAAATCCTC
AACTTGTTCTAGCTTGTGATCCCTCAAAGTTGGGTCATACGTTAGTGCTAGATACTAGAAATTTTCACTTTTCCACTGATCAGAGAGACA
GACATTAAAAACAAAAATAGAAGAAAGGAAAGCTTTCACCCTGCAGCTTCTTAGCAGGGAACAATTGTCTTGCCAAAACTTTTTTCCCTT
TTCTCTCCCATTTTCTTTTACCCAATCCCTTCTTACTCCTTGCCAGTGTGACCATGCTTTCTTCTCTGTAGATGTTAACAGTTAAGGCCT
ATTTTCCTCGGGCACTTAACCAACCAATCAGAACACCACATCTGTTAGGGGAGGTAACCTGGCCAACAGTGTATCCATCACGTTAGCCCT
GCTGGAGGGAAGGGACCCACATTCACCTGCCCTCTGACCTGCCCCTTGATCCCATATCTATTACCGTGTCCATAGGAATAATAGGTAAGG
GCTCTGTCTCTGTCAAGCCATGTAACAAAGGACACTGTTAAAAAAAAAAAAAAGTCTGGCATCAGAGGGAGCATGTGGAGAGCAACTTGG
GAAGAACAAGTTCATTTTGTATTGAATGATTTTTAATGAATGCAATATTAATCCTTGCAGATGAGCAATAATCATTAAAATCGATTAAAA

>30273_30273_2_FGFR2-AHCYL1_FGFR2_chr10_123243212_ENST00000369056_AHCYL1_chr1_110551654_ENST00000369799_length(amino acids)=1258AA_BP=768
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQIQFADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYT
DSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQC
RWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRL
YQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACM
DGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRL

--------------------------------------------------------------
>30273_30273_3_FGFR2-AHCYL1_FGFR2_chr10_123243212_ENST00000369061_AHCYL1_chr1_110551654_ENST00000369799_length(transcript)=5643nt_BP=2115nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAATCCAGTTTGCTGATGACATGCAGGAGTTCACCAAATTCCCC
ACCAAAACTGGCCGAAGATCTTTGTCTCGCTCGATCTCACAGTCCTCCACTGACAGCTACAGTTCAGCTGCATCCTACACAGATAGCTCT
GATGATGAGGTTTCTCCCCGAGAGAAGCAGCAAACCAACTCCAAGGGCAGCAGCAATTTCTGTGTGAAGAACATCAAGCAGGCAGAATTT
GGACGCCGGGAGATTGAGATTGCAGAGCAAGACATGTCTGCTCTGATTTCACTCAGGAAACGTGCTCAGGGGGAGAAGCCCTTGGCTGGT
GCTAAAATAGTGGGCTGTACACACATCACAGCCCAGACAGCGGTGTTGATTGAGACACTCTGTGCCCTGGGGGCTCAGTGCCGCTGGTCT
GCTTGTAACATCTACTCAACTCAGAATGAAGTAGCTGCAGCACTGGCTGAGGCTGGAGTTGCAGTGTTCGCTTGGAAGGGCGAGTCAGAA
GATGACTTCTGGTGGTGTATTGACCGCTGTGTGAACATGGATGGGTGGCAGGCCAACATGATCCTGGATGATGGGGGAGACTTAACCCAC
TGGGTTTATAAGAAGTATCCAAACGTGTTTAAGAAGATCCGAGGCATTGTGGAAGAGAGCGTGACTGGTGTTCACAGGCTGTATCAGCTC
TCCAAAGCTGGGAAGCTCTGTGTTCCGGCCATGAACGTCAATGATTCTGTTACCAAACAGAAGTTTGATAACTTGTACTGCTGCCGAGAA
TCCATTTTGGATGGCCTGAAGAGGACCACAGATGTGATGTTTGGTGGGAAACAAGTGGTGGTGTGTGGCTATGGTGAGGTAGGCAAGGGC
TGCTGTGCTGCTCTCAAAGCTCTTGGAGCAATTGTCTACATTACCGAAATCGACCCCATCTGTGCTCTGCAGGCCTGCATGGATGGGTTC
AGGGTGGTAAAGCTAAATGAAGTCATCCGGCAAGTCGATGTCGTAATAACTTGCACAGGAAATAAGAATGTAGTGACACGGGAGCACTTG
GATCGCATGAAAAACAGTTGTATCGTATGCAATATGGGCCACTCCAACACAGAAATCGATGTGACCAGCCTCCGCACTCCGGAGCTGACG
TGGGAGCGAGTACGTTCTCAGGTGGACCATGTCATCTGGCCAGATGGCAAACGAGTTGTCCTCCTGGCAGAGGGTCGTCTACTCAATTTG
AGCTGCTCCACAGTTCCCACCTTTGTTCTGTCCATCACAGCCACAACACAGGCTTTGGCACTGATAGAACTCTATAATGCACCCGAGGGG
CGATACAAGCAGGATGTGTACTTGCTTCCTAAGAAAATGGATGAATACGTTGCCAGCTTGCATCTGCCATCATTTGATGCCCACCTTACA
GAGCTGACAGATGACCAAGCAAAATATCTGGGACTCAACAAAAATGGGCCATTCAAACCTAATTATTACAGATACTAATGGACCATACTA
CCAAGGACCAGTCCACCTGAACCACACACTCTAAAGAAATATTTTTTAAGATAACTTTTATTTTCTTCTTACTCCTTTCCTCTTGATTTT
TTTCCTATAATTTCATTCTTGTTTTTTCATCTCATTATCCAAGTTCTGCAGACCACACAGGAACTTGCTTCATGGCTCTTTAGATGAAAT
AGAAGTTCAGGGTTCCTCACTCTAGTCACTAAAGAAGGATTTTACTCTCCCAGCCCAGAAAGGTGATTCTTTCTTTACCATTTCTGGGGA
CTTTAGTCTTAATTAGGTACCTTATTAACAGGAAATGCTAAGGTACCTTCTCTGTGGAACAATCTGCAATGTCTAAATCGCCTTAAAAGA
GCCCATTTCTTAGCTGCTGAAATCAGTGCTCTTTCACTTCTTCAGAGAAGCAGGGATGGTACCTACCCGGCAGGTAGGTTAGATGTGGGT
GGTGCATGTTAATTTCCCTTAGAAGTTCCAAGCCCTGTTTCCTGCGTAAAGGTGGTATGTCCAGTTCAGAGATGTGTATAATGAGCATGG
CTTGTTAAGATCAGGAGGCCCACTTGGATTTATAGTATAGCCCTTCCTCCACTCCCACCAGACTTGCTCATTTTTCGAGTTTTTAACTAG
ACTACACTCTATTGAGTTTAATTTTGTCCTCTAGGATTTATTTCTGTTGTCCAAAAAAAAAAAAAAAGAAAAGAAAAATTAAGGAGAATT
TTTGGTGTTAATGCTGAGGAATTGCTTGAGTGGTTAGTTGTTACCAATTTCTCTTTTGAACCTTTGGAGCTAAGGATGCTGAGTCTAGAG
AAATGCTAGTCTCAAGCCCTGTTAAGTCCCTCTGTTTCTAGCCCGTAGTTCATAGCATCAGTGAACTGGAGCCACAACAGCAAATTCTAT
CAGCTGTGTACCATACAGCTTGTGCTGAAGGCGAATTTCTTGAGCCATTACTCAGTATAAAGCACTGAGTTCTATCTTTAGGATTTATCT
TTAAGAGCAAATTTCTGGTCAGCTGTGCTTCTGCAACCTAAAATATTTAAAGGGAGGTAGGTGTGGGCAGGAGGAGGAATGATAAATTGG
GCCAGGGCAAGAAAAATCTAGCTTCATATAATTTGTCTGGGACTATACACCCTATATAATGTTAGTTTTACAGAAGTAATATGACTTTTG
ATTGCTACATACCACAAAGAGTTTATGAACTGAGATCATAAAGGGCAACTGATGTGTGAAGAAAGTAGTCAGTACATCCTGGCTCATGCT
CTGAAAGAATATCCAGAGAGGCTCTCTCAAAGATCAGGGAGATGTATTCCCATGCCATGCACCCTGCTTCCCAGCATTTCTGCATGGTCA
AGTGAGCTTTATGCTCATGAGCTTTAAGTATATAATTATCCAGGATTTTAAATCCTCAACTTGTTCTAGCTTGTGATCCCTCAAAGTTGG
GTCATACGTTAGTGCTAGATACTAGAAATTTTCACTTTTCCACTGATCAGAGAGACAGACATTAAAAACAAAAATAGAAGAAAGGAAAGC
TTTCACCCTGCAGCTTCTTAGCAGGGAACAATTGTCTTGCCAAAACTTTTTTCCCTTTTCTCTCCCATTTTCTTTTACCCAATCCCTTCT
TACTCCTTGCCAGTGTGACCATGCTTTCTTCTCTGTAGATGTTAACAGTTAAGGCCTATTTTCCTCGGGCACTTAACCAACCAATCAGAA
CACCACATCTGTTAGGGGAGGTAACCTGGCCAACAGTGTATCCATCACGTTAGCCCTGCTGGAGGGAAGGGACCCACATTCACCTGCCCT
CTGACCTGCCCCTTGATCCCATATCTATTACCGTGTCCATAGGAATAATAGGTAAGGGCTCTGTCTCTGTCAAGCCATGTAACAAAGGAC
ACTGTTAAAAAAAAAAAAAAGTCTGGCATCAGAGGGAGCATGTGGAGAGCAACTTGGGAAGAACAAGTTCATTTTGTATTGAATGATTTT

>30273_30273_3_FGFR2-AHCYL1_FGFR2_chr10_123243212_ENST00000369061_AHCYL1_chr1_110551654_ENST00000369799_length(amino acids)=1179AA_BP=689
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQIQFADDMQEFTKFPTKTGRRSLSRSISQSS
TDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVL
IETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGI
VEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITE
IDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDG
KRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FGFR2-AHCYL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000359172017138_2010484.0BCL2L10
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000369799017138_20140.0531.0BCL2L10
TgeneAHCYL1chr10:123243212chr1:110551654ENST00000393614017138_2010484.0BCL2L10


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR2-AHCYL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGFR2-AHCYL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource