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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR2-AP1M1 (FusionGDB2 ID:30275)

Fusion Gene Summary for FGFR2-AP1M1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2-AP1M1
Fusion gene ID: 30275
HgeneTgene
Gene symbol

FGFR2

AP1M1

Gene ID

2263

8907

Gene namefibroblast growth factor receptor 2adaptor related protein complex 1 subunit mu 1
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25AP47|CLAPM2|CLTNM|MU-1A
Cytomap

10q26.13

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14AP-1 complex subunit mu-1AP-mu chain family member mu1AHA1 47 kDa subunitadapter-related protein complex 1 subunit mu-1adaptor protein complex AP-1 mu-1 subunitadaptor protein complex AP-1 subunit mu-1adaptor related protein complex 1 mu 1 subunitc
Modification date2020032220200313
UniProtAcc

P21802

Q9BXS5

Ensembl transtripts involved in fusion geneENST00000346997, ENST00000351936, 
ENST00000356226, ENST00000357555, 
ENST00000358487, ENST00000360144, 
ENST00000369056, ENST00000369059, 
ENST00000369060, ENST00000369061, 
ENST00000457416, ENST00000478859, 
ENST00000359354, ENST00000490349, 
ENST00000429941, ENST00000444449, 
ENST00000541844, ENST00000590756, 
ENST00000291439, 
Fusion gene scores* DoF score24 X 20 X 12=57605 X 5 X 4=100
# samples 386
** MAII scorelog2(38/5760*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR2 [Title/Abstract] AND AP1M1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR2(123256046)-AP1M1(16314270), # samples:2
Anticipated loss of major functional domain due to fusion event.FGFR2-AP1M1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR2-AP1M1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR2-AP1M1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check buttonFusion gene breakpoints across FGFR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AP1M1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04L-01BFGFR2chr10

123256046

-AP1M1chr19

16314270

+


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Fusion Gene ORF analysis for FGFR2-AP1M1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346997ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000346997ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000346997ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000346997ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000351936ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000356226ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000357555ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000358487ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000360144ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000369059ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000369060ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000457416ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000478859ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
In-frameENST00000346997ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
In-frameENST00000369056ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
In-frameENST00000369061ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-3CDSENST00000359354ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-3CDSENST00000490349ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369061FGFR2chr10123256046-ENST00000291439AP1M1chr1916314270+38211677482906952
ENST00000346997FGFR2chr10123256046-ENST00000291439AP1M1chr1916314270+401318691230981028
ENST00000369056FGFR2chr10123256046-ENST00000291439AP1M1chr1916314270+403418902431191031

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369061ENST00000291439FGFR2chr10123256046-AP1M1chr1916314270+0.0005926210.9994074
ENST00000346997ENST00000291439FGFR2chr10123256046-AP1M1chr1916314270+0.0003281610.9996718
ENST00000369056ENST00000291439FGFR2chr10123256046-AP1M1chr1916314270+0.0004456010.99955434

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Fusion Genomic Features for FGFR2-AP1M1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGFR2chr10123256045-AP1M1chr1916314269+3.36E-121
FGFR2chr10123256045-AP1M1chr1916314269+3.36E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGFR2-AP1M1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123256046/chr19:16314270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

AP1M1

Q9BXS5

FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217154_247619820.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217256_358619820.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-121725_125619820.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318154_247619786.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318256_358619786.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-131825_125619786.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116154_247504705.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116256_358504705.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-111625_125504705.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217154_247532708.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217256_358532708.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-121725_125532708.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318154_247621822.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318256_358621822.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-131825_125621822.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217154_247533681.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217256_358533681.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-121725_125533681.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217154_247622770.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217256_358622770.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-121725_125622770.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116154_247505706.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116256_358505706.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-111625_125505706.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015154_247509710.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015256_358509710.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-101525_125509710.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318154_247622823.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318256_358622823.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-131825_125622823.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217487_495619820.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217565_567619820.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318487_495619786.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318565_567619786.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116487_495504705.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217487_495532708.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318487_495621822.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318565_567621822.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217487_495533681.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217487_495622770.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217565_567622770.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116487_495505706.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015487_495509710.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318487_495622823.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318565_567622823.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217161_178619820.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318161_178619786.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116161_178504705.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217161_178532708.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318161_178621822.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217161_178533681.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217161_178622770.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116161_178505706.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015161_178509710.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318161_178622823.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-121722_377619820.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-131822_377619786.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-111622_377504705.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-121722_377532708.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-131822_377621822.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-121722_377533681.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-121722_377622770.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-111622_377505706.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-101522_377509710.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-131822_377622823.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217378_398619820.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318378_398619786.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116378_398504705.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217378_398532708.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318378_398621822.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217378_398533681.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217378_398622770.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116378_398505706.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015378_398509710.0TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318378_398622823.0TransmembraneHelical
TgeneAP1M1chr10:123256046chr19:16314270ENST00000291439012168_42114424.0DomainMHD
TgeneAP1M1chr10:123256046chr19:16314270ENST00000444449013168_42114436.0DomainMHD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217481_770619820.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318481_770619786.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116481_770504705.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217481_770532708.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318481_770621822.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17154_2470255.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17256_3580255.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-1725_1250255.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17481_7700255.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217481_770533681.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217481_770622770.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116481_770505706.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015481_770509710.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318481_770622823.0DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116565_567504705.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217565_567532708.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17487_4950255.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17565_5670255.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217565_567533681.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116565_567505706.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015565_567509710.0Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17161_1780255.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217399_821619820.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318399_821619786.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116399_821504705.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217399_821532708.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318399_821621822.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-1722_3770255.0Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17399_8210255.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217399_821533681.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217399_821622770.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116399_821505706.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015399_821509710.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318399_821622823.0Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17378_3980255.0TransmembraneHelical


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Fusion Gene Sequence for FGFR2-AP1M1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30275_30275_1_FGFR2-AP1M1_FGFR2_chr10_123256046_ENST00000346997_AP1M1_chr19_16314270_ENST00000291439_length(transcript)=4013nt_BP=1869nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAAGTGCTCATCTGCCGGAACTAC
CGTGGCGACGTGGACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCGCCCATCCTGGCC
CACGGGGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAACGCGTGCGTGTCGCTGGTCTTT
TCTTTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTTATCATCTAC
GAGCTGCTGGACGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAG
CTGGAAACAGGGGCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTG
TTCTTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGA
GTCTTCCTCTCGGGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGCCGCGGCAAAAGCAAATCCGTG
GAGCTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCCTTCATCCCACCCGACGGCGAG
TTCGAGCTCATGTCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAGAAGCACTCCCACAGCCGCATC
GAGTACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCCAATGATGCCGAC
TCACCCAAGTTCAAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCCGGGCGGC
AAGGAGTACCTGATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCCCCGATCAGTGTCAAGTTCGAG
ATCCCTTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCCTGGGTGCGTTAT
ATCACGCAGAATGGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCAGCCAACACCCCGGCCTCGGGGCTCCTGGTGGCAGCACCA
GGGGACACACCTGCCAAACCCACCAGATGGAGGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCTGCCCAGGGACCCCTGCCTTCC
CCAGGCCATCTGCTCTGCCGTCGACACTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTCAAGAAGTCTCGTTTCTTTGCCCCT
GAAGTCAGTTTCAGGGGAAGGATGTGAAATTTTTCCGTGTAGAGGTTACAGCCTTTTATGCTGTTGAGCTCCCAGGTACCAAAAAGCTTG
GCCAACGCTTGCCAGCCAGCCAGCTGCAGGTGGCATCTGCCACGAAGGAAGCGCCAGCCTCGCCAGGCCAGCAGGGGCGTCGTTTTGTTG
CCATTTTGTTGAACGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCATTCGTTGCTGTTTGTGTTACCCTCACTGTCCCCAT
GTCCCACCCACGTCCTACGGCACTCAGGAAGCACTTGGTGAGGACGAGCCCTCACCCTTCTTGTCTTCCTTCCCGGCAGCGCCCGCAGCG
GGCCATTTACACGTCGAGGCTGGCACCTGGCGCGCTCGGGGGCCACTGTAGCGTCTGCCTGCTCCCTGGACTCGCAGGCCTCGCCTGTGG
CGCCTTCCCAGGGCCAGCCTGGGTCACGAGATGCTGTCACTCAGCCAGATCAGTATTGACCCACCAGGGGAGGTGGGGTTTGGTGAGAGA
CGCCAGCCTCAGACTTTTTCCCACTGAGGGTCCAGAGAGCGGGGCCACGTGTCACCCACGTCTGCGCTTGGTCACCCGTCCTCCCCACCC

>30275_30275_1_FGFR2-AP1M1_FGFR2_chr10_123256046_ENST00000346997_AP1M1_chr19_16314270_ENST00000291439_length(amino acids)=1028AA_BP=619
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKVLICRNYRGDV
DMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLD
ELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLS
GMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMI
KAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYF

--------------------------------------------------------------
>30275_30275_2_FGFR2-AP1M1_FGFR2_chr10_123256046_ENST00000369056_AP1M1_chr19_16314270_ENST00000291439_length(transcript)=4034nt_BP=1890nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
GTGCTCATCTGCCGGAACTACCGTGGCGACGTGGACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGG
ATGCTGTCGCCCATCCTGGCCCACGGGGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAAC
GCGTGCGTGTCGCTGGTCTTTTCTTTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGG
GACAACTTTGTTATCATCTACGAGCTGCTGGACGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTAC
ATCACTCAGGAAGGCCACAAGCTGGAAACAGGGGCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATC
AAGTATCGGAAGAATGAGGTGTTCTTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATC
GTGGGCTCCATCAAGATGCGAGTCTTCCTCTCGGGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGC
CGCGGCAAAAGCAAATCCGTGGAGCTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCC
TTCATCCCACCCGACGGCGAGTTCGAGCTCATGTCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAG
AAGCACTCCCACAGCCGCATCGAGTACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATT
CCCGTGCCCAATGATGCCGACTCACCCAAGTTCAAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCC
ATCAAGTCCTTCCCGGGCGGCAAGGAGTACCTGATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCC
CCGATCAGTGTCAAGTTCGAGATCCCTTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAG
GCCCTGCCCTGGGTGCGTTATATCACGCAGAATGGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCAGCCAACACCCCGGCCTCG
GGGCTCCTGGTGGCAGCACCAGGGGACACACCTGCCAAACCCACCAGATGGAGGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCT
GCCCAGGGACCCCTGCCTTCCCCAGGCCATCTGCTCTGCCGTCGACACTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTCAAG
AAGTCTCGTTTCTTTGCCCCTGAAGTCAGTTTCAGGGGAAGGATGTGAAATTTTTCCGTGTAGAGGTTACAGCCTTTTATGCTGTTGAGC
TCCCAGGTACCAAAAAGCTTGGCCAACGCTTGCCAGCCAGCCAGCTGCAGGTGGCATCTGCCACGAAGGAAGCGCCAGCCTCGCCAGGCC
AGCAGGGGCGTCGTTTTGTTGCCATTTTGTTGAACGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCATTCGTTGCTGTTTG
TGTTACCCTCACTGTCCCCATGTCCCACCCACGTCCTACGGCACTCAGGAAGCACTTGGTGAGGACGAGCCCTCACCCTTCTTGTCTTCC
TTCCCGGCAGCGCCCGCAGCGGGCCATTTACACGTCGAGGCTGGCACCTGGCGCGCTCGGGGGCCACTGTAGCGTCTGCCTGCTCCCTGG
ACTCGCAGGCCTCGCCTGTGGCGCCTTCCCAGGGCCAGCCTGGGTCACGAGATGCTGTCACTCAGCCAGATCAGTATTGACCCACCAGGG
GAGGTGGGGTTTGGTGAGAGACGCCAGCCTCAGACTTTTTCCCACTGAGGGTCCAGAGAGCGGGGCCACGTGTCACCCACGTCTGCGCTT

>30275_30275_2_FGFR2-AP1M1_FGFR2_chr10_123256046_ENST00000369056_AP1M1_chr19_16314270_ENST00000291439_length(amino acids)=1031AA_BP=622
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKVLICRNYR
GDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYE
LLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRV
FLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIE
YMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEI

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>30275_30275_3_FGFR2-AP1M1_FGFR2_chr10_123256046_ENST00000369061_AP1M1_chr19_16314270_ENST00000291439_length(transcript)=3821nt_BP=1677nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAAGTGCTCATCTGCCGGAACTACCGTGGCGACGTG
GACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCGCCCATCCTGGCCCACGGGGGGGTC
CGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAACGCGTGCGTGTCGCTGGTCTTTTCTTTCCTCTAT
AAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTTATCATCTACGAGCTGCTGGAC
GAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAGCTGGAAACAGGG
GCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTGTTCTTGGACGTC
ATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGAGTCTTCCTCTCG
GGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGCCGCGGCAAAAGCAAATCCGTGGAGCTGGAGGAT
GTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCCTTCATCCCACCCGACGGCGAGTTCGAGCTCATG
TCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAGAAGCACTCCCACAGCCGCATCGAGTACATGATC
AAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCCAATGATGCCGACTCACCCAAGTTC
AAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCCGGGCGGCAAGGAGTACCTG
ATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCCCCGATCAGTGTCAAGTTCGAGATCCCTTACTTC
ACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCCTGGGTGCGTTATATCACGCAGAAT
GGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCAGCCAACACCCCGGCCTCGGGGCTCCTGGTGGCAGCACCAGGGGACACACCT
GCCAAACCCACCAGATGGAGGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCTGCCCAGGGACCCCTGCCTTCCCCAGGCCATCTG
CTCTGCCGTCGACACTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTCAAGAAGTCTCGTTTCTTTGCCCCTGAAGTCAGTTTC
AGGGGAAGGATGTGAAATTTTTCCGTGTAGAGGTTACAGCCTTTTATGCTGTTGAGCTCCCAGGTACCAAAAAGCTTGGCCAACGCTTGC
CAGCCAGCCAGCTGCAGGTGGCATCTGCCACGAAGGAAGCGCCAGCCTCGCCAGGCCAGCAGGGGCGTCGTTTTGTTGCCATTTTGTTGA
ACGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCATTCGTTGCTGTTTGTGTTACCCTCACTGTCCCCATGTCCCACCCACG
TCCTACGGCACTCAGGAAGCACTTGGTGAGGACGAGCCCTCACCCTTCTTGTCTTCCTTCCCGGCAGCGCCCGCAGCGGGCCATTTACAC
GTCGAGGCTGGCACCTGGCGCGCTCGGGGGCCACTGTAGCGTCTGCCTGCTCCCTGGACTCGCAGGCCTCGCCTGTGGCGCCTTCCCAGG
GCCAGCCTGGGTCACGAGATGCTGTCACTCAGCCAGATCAGTATTGACCCACCAGGGGAGGTGGGGTTTGGTGAGAGACGCCAGCCTCAG
ACTTTTTCCCACTGAGGGTCCAGAGAGCGGGGCCACGTGTCACCCACGTCTGCGCTTGGTCACCCGTCCTCCCCACCCTGTGTGTGTTTA

>30275_30275_3_FGFR2-AP1M1_FGFR2_chr10_123256046_ENST00000369061_AP1M1_chr19_16314270_ENST00000291439_length(amino acids)=952AA_BP=543
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEE
SIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLR
SEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIES
VIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKE

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Fusion Gene PPI Analysis for FGFR2-AP1M1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR2-AP1M1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGFR2-AP1M1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource