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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR2-CCDC6 (FusionGDB2 ID:30282)

Fusion Gene Summary for FGFR2-CCDC6

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2-CCDC6
Fusion gene ID: 30282
HgeneTgene
Gene symbol

FGFR2

CCDC6

Gene ID

2263

8030

Gene namefibroblast growth factor receptor 2coiled-coil domain containing 6
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25D10S170|H4|PTC|TPC|TST1
Cytomap

10q26.13

10q21.2

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14coiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded protein
Modification date2020032220200327
UniProtAcc

P21802

A6NI79

Ensembl transtripts involved in fusion geneENST00000351936, ENST00000356226, 
ENST00000357555, ENST00000358487, 
ENST00000360144, ENST00000369059, 
ENST00000369060, ENST00000457416, 
ENST00000478859, ENST00000346997, 
ENST00000369056, ENST00000369061, 
ENST00000359354, ENST00000490349, 
ENST00000263102, 
Fusion gene scores* DoF score24 X 20 X 12=576012 X 8 X 6=576
# samples 3814
** MAII scorelog2(38/5760*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/576*10)=-2.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR2 [Title/Abstract] AND CCDC6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR2(123243212)-CCDC6(61612460), # samples:3
Anticipated loss of major functional domain due to fusion event.FGFR2-CCDC6 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR2-CCDC6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR2-CCDC6 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
FGFR2-CCDC6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FGFR2-CCDC6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check buttonFusion gene breakpoints across FGFR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A13Z-01AFGFR2chr10

123243212

-CCDC6chr10

61612460

-


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Fusion Gene ORF analysis for FGFR2-CCDC6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000351936ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000356226ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000357555ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000358487ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000360144ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000369059ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000369060ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000457416ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
Frame-shiftENST00000478859ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
In-frameENST00000346997ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
In-frameENST00000369056ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
In-frameENST00000369061ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
intron-3CDSENST00000359354ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-
intron-3CDSENST00000490349ENST00000263102FGFR2chr10

123243212

-CCDC6chr10

61612460

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369061FGFR2chr10123243212-ENST00000263102CCDC6chr1061612460-739121154832361062
ENST00000346997FGFR2chr10123243212-ENST00000263102CCDC6chr1061612460-758323071234281138
ENST00000369056FGFR2chr10123243212-ENST00000263102CCDC6chr1061612460-760423282434491141

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369061ENST00000263102FGFR2chr10123243212-CCDC6chr1061612460-0.0001854930.99981457
ENST00000346997ENST00000263102FGFR2chr10123243212-CCDC6chr1061612460-0.0002147710.99978524
ENST00000369056ENST00000263102FGFR2chr10123243212-CCDC6chr1061612460-0.0001763850.99982363

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Fusion Genomic Features for FGFR2-CCDC6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FGFR2-CCDC6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123243212/chr10:61612460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

CCDC6

A6NI79

FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.FUNCTION: May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. {ECO:0000305|PubMed:20962590}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617154_247765820.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617256_358765820.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-161725_125765820.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718154_247765786.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718256_358765786.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-171825_125765786.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516154_247650705.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516256_358650705.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-151625_125650705.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617154_247678708.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617256_358678708.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-161725_125678708.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718154_247767822.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718256_358767822.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-171825_125767822.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718481_770767822.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617154_247679681.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617256_358679681.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-161725_125679681.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617154_247768770.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617256_358768770.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-161725_125768770.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617481_770768770.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516154_247651706.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516256_358651706.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-151625_125651706.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415154_247655710.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415256_358655710.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-141525_125655710.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718154_247768823.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718256_358768823.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-171825_125768823.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718481_770768823.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617487_495765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617565_567765820.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718487_495765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718565_567765786.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516487_495650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516565_567650705.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617487_495678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617565_567678708.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718487_495767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718565_567767822.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617487_495679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617565_567679681.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617487_495768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617565_567768770.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516487_495651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516565_567651706.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415487_495655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415565_567655710.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718487_495768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718565_567768823.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617161_178765820.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718161_178765786.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516161_178650705.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617161_178678708.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718161_178767822.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617161_178679681.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617161_178768770.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516161_178651706.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415161_178655710.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718161_178768823.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-161722_377765820.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-171822_377765786.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-151622_377650705.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-161722_377678708.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-171822_377767822.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-161722_377679681.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-161722_377768770.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-151622_377651706.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-141522_377655710.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-171822_377768823.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617378_398765820.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718378_398765786.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516378_398650705.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617378_398678708.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718378_398767822.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617378_398679681.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617378_398768770.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516378_398651706.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415378_398655710.0TransmembraneHelical
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718378_398768823.0TransmembraneHelical
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209253_332101475.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209440_448101475.0Compositional biasNote=Poly-Pro
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209442_451101475.0MotifSH3-binding
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209106_235101475.0RegionNote=5 X 29 AA tandem repeats
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209106_134101475.0RepeatNote=1
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209135_163101475.0RepeatNote=2
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209164_192101475.0RepeatNote=3
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209193_206101475.0RepeatNote=4%3B approximate
TgeneCCDC6chr10:123243212chr10:61612460ENST0000026310209207_235101475.0RepeatNote=5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617481_770765820.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718481_770765786.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516481_770650705.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617481_770678708.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17154_2470255.0DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17256_3580255.0DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-1725_1250255.0DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17481_7700255.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617481_770679681.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516481_770651706.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415481_770655710.0DomainProtein kinase
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17487_4950255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17565_5670255.0Nucleotide bindingATP
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17161_1780255.0RegionNote=Heparin-binding
HgeneFGFR2chr10:123243212chr10:61612460ENST00000346997-1617399_821765820.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000351936-1718399_821765786.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000356226-1516399_821650705.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000357555-1617399_821678708.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000358487-1718399_821767822.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-1722_3770255.0Topological domainExtracellular
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17399_8210255.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000360144-1617399_821679681.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369056-1617399_821768770.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369060-1516399_821651706.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000369061-1415399_821655710.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000457416-1718399_821768823.0Topological domainCytoplasmic
HgeneFGFR2chr10:123243212chr10:61612460ENST00000359354-17378_3980255.0TransmembraneHelical
TgeneCCDC6chr10:123243212chr10:61612460ENST000002631020953_237101475.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC6chr10:123243212chr10:61612460ENST000002631020917_20101475.0Compositional biasNote=Poly-Ser
TgeneCCDC6chr10:123243212chr10:61612460ENST000002631020932_44101475.0Compositional biasNote=Poly-Gly


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Fusion Gene Sequence for FGFR2-CCDC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30282_30282_1_FGFR2-CCDC6_FGFR2_chr10_123243212_ENST00000346997_CCDC6_chr10_61612460_ENST00000263102_length(transcript)=7583nt_BP=2307nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCA
GCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAA
AAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCC
TTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAA
GGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCA
ACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATT
AGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACT
AATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTTCAGGTCAAC
AAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAGATTGACCTT
GAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGAATCCTGCAG
GAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATGCGTCACATC
AGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAGTATCTGGAG
GAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGTCGACAGCTC
TCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACTGTGTCCAGC
CCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTCACGCCACCA
ACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATCACAAGGCCT
TCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAGCCACCTCCG
CCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCACCCCTCCTCC
CAGCCTTAATGCATGAGCTTAGTCTGAATTTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACGCCAAAGGCTTCCTTCTCTGGC
ATATTTGGATATGACTTATTTGCACTGAGGTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTGTCAGAAATGCAGCCAGTGTTG
TGGGTCTACAACACTAACCAGACGACTTTTTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATTCCCTGGCTGGAACCTTCGCTG
TTTGGTATTTGGTATTTCAGCAGCAGTGTGCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTTTAGGTTTGTAAAAGAAAAAGG
GATATCTTTTTTATATTTTTTTCCATGAATCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCATTATAATAGTGTTTACCAAACA
TACCAATAATTCAGCACTACAATTCAGACCTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGATGAATCAGTGCCCAAGACATA
TTTTCTGTTTAACAGAACTTTCTACAGATACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCCATGTCTCTCGTAAAACAGATG
GCCCAAAGTAATGAATCATGTGGCTGTACCTTCTCCACATAAATGGGATGGATAATTATCGTATATTAAGATGTGATTCTCTTTTTTATC
CTTAATGTTAATCTACTTAACCTGGCCCCCTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTGGTTTCAATGGCTAATTAGAAT
GTGTTATTTGATTTCTGCTGCAGAAGGCAGTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGTACTTCATTTGTGTTCTCTTAA
AATAGAGTTTGAACAAATATTTTAAAGGTGCAAAATACCATTAGAAAATACTATTTGAAATGGACATTATCGCATTATCTTGGCATAATG
GCCAGAAAATATTGTATTGCTTGGCAGAAAAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTGATGGCTGTTCATTTCACCCAG
TATAAGCAAGTGCAGTGTACAAAGAAGTATATTCTGAATACATTATTTCCATTCATTTAGCACAAATAAATCATTTGGTTTCACTTTGCA
GTGGAACACTGAGTCACTCTTTTCTTAACACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGTTTTGTACTTTGGTAGTAAAGT
GATTTTTACCACCTGTGTTTGCATATTTATATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATATTTTATGACAAGAATGTGTAT
CTGTTGGATATAATCAGAGAACTGAAAAGTAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACAACCATCTCTAATAGCCAACTC
TTTATTAAACACACTCCTAAAAATAAGGAACCATGACATTGTAGATATTTAATATTGTACAGTATAGAAACCTCCATTTTTGCCTTCGAA
TGCATATTTAAGAGTTAACAGAATGAAAAAAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTTAAGAACTTGAGAGTAAAAGCA
ACAATAAGATTTTTTCACCTCTTCCTGCTTCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAGAAACTGTAGGTCTATATAAAT
TTTATTTATAATGTATGTGTAATATACATAATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGCATTTAATCATTGAGGCTTTAG
GTTTTTGATGTGATCAGACTGGGCCATGTCAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTGGTACATTGCCATTCCAAGGAA
TTCTGAGAGTAGGCAAACAAATTTTGCCTTCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATGGTATATGTTTATAAGAATCTT
TTATGAGATTATAGATTTCAATGCTGTGGATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAATGATCTTCCCTCAGCTTCCTAT
CGATTTAGTTACCTCTTGAAAGCACAAAAATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTTGGAGTGAGCGAACATTTCCTG
ATAAATGCCTTTTAGAGATAGGTTCTTGATATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCATTTCACTTCGAAATAAAACAC
AGCTCCTTCAAACAGCACTTTTTCCACATAAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATAGAACAAACACTACTCTTTTGA
ATTTGATGGTTCGTGTCCTTTAAAGTGTTTGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCTGCTAGGACAATTTCTTGGCAA
TTGTCTTACTACTAGGGATCAGTAAGATTTAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTATGGGAAGCTGACTTCCCTCAGT
CGGGCACTTCTCATGGGGGCTGAACATGGTTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTGGATTGGCTCCCAGAAGGCCTT
TGTAAAATCAGTAGCCGTCCTGCAGGCAGGTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTCTTGCAGACAGAGACCCTTGGC
TACCACTGTGCTGCTAATAGGATAAGTACTCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAATTAACTTACCTAATACCTGACA
CCTCTTTGGGCTCTGAACTGCTTTCTCTCATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTTGGCAGATAGTGGAAGCCTTTA
ATTGAACTTACTCCTTCGTTGACTGAAAGGAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAACCATGGAATGAATGTGTGACCA
GAAAGTGGCTTTGACACCAAGTGCTACTGTCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAATAATTGATAATGTGAATTTTTG
TTAATTGTTCACTTGTAGGAAAATAGAACATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGCACAAAGCCTTGCTTTTAGAGA
ATGCCCAATAAGGCAAGAAAAAGCATAGTAACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGTACAGAAGAAATATTTCTGTGT
AACTTGATCTTCTGTCTAGTACTTGTCTTATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACCAAAGAAATACATAGTAAAACA
ACCTTTTATTTCCAAATTGTTAAAGAGCCAGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCCATTGTAAGAGATTAAGGGGTT
TCTAGGTTTTTGGTGATTTTTTGTTTGTTTTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATTTTTTGATTAAAACATACACAC
AGCTGTTAGCATAAAGTCGTGGGGGGCATTTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCCAGGTTGCCTCTCATGAGGCAA
CTGAAAAAATCCTGTGTCTTGATAGCATGGGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCTTAACTCGGGTTACTGCACAAC
TTTAGTTCTTGACTTAGTCTGCACCGTCATCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTGGCAAAAACAAAGTTGCAGGCA
CAACAGTTTAAGAATGCATTCCTCCAGAAGAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACTTGATTTGGAACTTAGCCTGGA
AAGCGAAAGTGGACTGTCCAACAGAAAGATGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCCTTTTGCCTCTGCATATCTGTG
CACACTGTATGTTGTTCATGATAGCTTGTCTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAATCTTGACATTCTTGGTCAGAG
TTTAGAGAGATGTAAGACTTTCAATTAATGTCTTATTTACTCCTTTATGTTGATTAGTCTTTGATACATGTGCTGAATCAGAAACCTAAA

>30282_30282_1_FGFR2-CCDC6_FGFR2_chr10_123243212_ENST00000346997_CCDC6_chr10_61612460_ENST00000263102_length(amino acids)=1138AA_BP=765
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM
DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELS
RKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLD
QPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESE
SSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRR

--------------------------------------------------------------
>30282_30282_2_FGFR2-CCDC6_FGFR2_chr10_123243212_ENST00000369056_CCDC6_chr10_61612460_ENST00000263102_length(transcript)=7604nt_BP=2328nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATC
AACAATATAGACTATTACAAAAAGACCACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACT
CATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAA
CTTTTTAAGCTGCTGAAGGAAGGACACAGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCAT
GCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCT
GAGCAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAG
AAAGAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAA
GAGCAGGAATTTCAGGTCAACAAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTG
AGACGGGAGAAGATTGACCTTGAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAA
GCTGAAAAGCGAATCCTGCAGGAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCA
GAAAATATGATGCGTCACATCAGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAG
AAAATGGCACAGTATCTGGAGGAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGA
GAAGCCCTCTGTCGACAGCTCTCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTA
AGACCTCGCACTGTGTCCAGCCCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCAC
ACGGTTGGTTTCACGCCACCAACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACA
TCCCATGGTATCACAAGGCCTTCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAG
ACCCCAGTCCAGCCACCTCCGCCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAA
CATTCGGCGCACCCCTCCTCCCAGCCTTAATGCATGAGCTTAGTCTGAATTTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACG
CCAAAGGCTTCCTTCTCTGGCATATTTGGATATGACTTATTTGCACTGAGGTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTG
TCAGAAATGCAGCCAGTGTTGTGGGTCTACAACACTAACCAGACGACTTTTTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATT
CCCTGGCTGGAACCTTCGCTGTTTGGTATTTGGTATTTCAGCAGCAGTGTGCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTT
TAGGTTTGTAAAAGAAAAAGGGATATCTTTTTTATATTTTTTTCCATGAATCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCAT
TATAATAGTGTTTACCAAACATACCAATAATTCAGCACTACAATTCAGACCTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGA
TGAATCAGTGCCCAAGACATATTTTCTGTTTAACAGAACTTTCTACAGATACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCC
ATGTCTCTCGTAAAACAGATGGCCCAAAGTAATGAATCATGTGGCTGTACCTTCTCCACATAAATGGGATGGATAATTATCGTATATTAA
GATGTGATTCTCTTTTTTATCCTTAATGTTAATCTACTTAACCTGGCCCCCTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTG
GTTTCAATGGCTAATTAGAATGTGTTATTTGATTTCTGCTGCAGAAGGCAGTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGT
ACTTCATTTGTGTTCTCTTAAAATAGAGTTTGAACAAATATTTTAAAGGTGCAAAATACCATTAGAAAATACTATTTGAAATGGACATTA
TCGCATTATCTTGGCATAATGGCCAGAAAATATTGTATTGCTTGGCAGAAAAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTG
ATGGCTGTTCATTTCACCCAGTATAAGCAAGTGCAGTGTACAAAGAAGTATATTCTGAATACATTATTTCCATTCATTTAGCACAAATAA
ATCATTTGGTTTCACTTTGCAGTGGAACACTGAGTCACTCTTTTCTTAACACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGT
TTTGTACTTTGGTAGTAAAGTGATTTTTACCACCTGTGTTTGCATATTTATATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATA
TTTTATGACAAGAATGTGTATCTGTTGGATATAATCAGAGAACTGAAAAGTAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACA
ACCATCTCTAATAGCCAACTCTTTATTAAACACACTCCTAAAAATAAGGAACCATGACATTGTAGATATTTAATATTGTACAGTATAGAA
ACCTCCATTTTTGCCTTCGAATGCATATTTAAGAGTTAACAGAATGAAAAAAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTT
AAGAACTTGAGAGTAAAAGCAACAATAAGATTTTTTCACCTCTTCCTGCTTCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAG
AAACTGTAGGTCTATATAAATTTTATTTATAATGTATGTGTAATATACATAATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGC
ATTTAATCATTGAGGCTTTAGGTTTTTGATGTGATCAGACTGGGCCATGTCAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTG
GTACATTGCCATTCCAAGGAATTCTGAGAGTAGGCAAACAAATTTTGCCTTCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATG
GTATATGTTTATAAGAATCTTTTATGAGATTATAGATTTCAATGCTGTGGATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAAT
GATCTTCCCTCAGCTTCCTATCGATTTAGTTACCTCTTGAAAGCACAAAAATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTT
GGAGTGAGCGAACATTTCCTGATAAATGCCTTTTAGAGATAGGTTCTTGATATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCA
TTTCACTTCGAAATAAAACACAGCTCCTTCAAACAGCACTTTTTCCACATAAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATA
GAACAAACACTACTCTTTTGAATTTGATGGTTCGTGTCCTTTAAAGTGTTTGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCT
GCTAGGACAATTTCTTGGCAATTGTCTTACTACTAGGGATCAGTAAGATTTAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTAT
GGGAAGCTGACTTCCCTCAGTCGGGCACTTCTCATGGGGGCTGAACATGGTTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTG
GATTGGCTCCCAGAAGGCCTTTGTAAAATCAGTAGCCGTCCTGCAGGCAGGTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTC
TTGCAGACAGAGACCCTTGGCTACCACTGTGCTGCTAATAGGATAAGTACTCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAAT
TAACTTACCTAATACCTGACACCTCTTTGGGCTCTGAACTGCTTTCTCTCATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTT
GGCAGATAGTGGAAGCCTTTAATTGAACTTACTCCTTCGTTGACTGAAAGGAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAAC
CATGGAATGAATGTGTGACCAGAAAGTGGCTTTGACACCAAGTGCTACTGTCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAAT
AATTGATAATGTGAATTTTTGTTAATTGTTCACTTGTAGGAAAATAGAACATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGC
ACAAAGCCTTGCTTTTAGAGAATGCCCAATAAGGCAAGAAAAAGCATAGTAACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGT
ACAGAAGAAATATTTCTGTGTAACTTGATCTTCTGTCTAGTACTTGTCTTATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACC
AAAGAAATACATAGTAAAACAACCTTTTATTTCCAAATTGTTAAAGAGCCAGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCC
ATTGTAAGAGATTAAGGGGTTTCTAGGTTTTTGGTGATTTTTTGTTTGTTTTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATT
TTTTGATTAAAACATACACACAGCTGTTAGCATAAAGTCGTGGGGGGCATTTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCC
AGGTTGCCTCTCATGAGGCAACTGAAAAAATCCTGTGTCTTGATAGCATGGGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCT
TAACTCGGGTTACTGCACAACTTTAGTTCTTGACTTAGTCTGCACCGTCATCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTG
GCAAAAACAAAGTTGCAGGCACAACAGTTTAAGAATGCATTCCTCCAGAAGAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACT
TGATTTGGAACTTAGCCTGGAAAGCGAAAGTGGACTGTCCAACAGAAAGATGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCC
TTTTGCCTCTGCATATCTGTGCACACTGTATGTTGTTCATGATAGCTTGTCTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAA
TCTTGACATTCTTGGTCAGAGTTTAGAGAGATGTAAGACTTTCAATTAATGTCTTATTTACTCCTTTATGTTGATTAGTCTTTGATACAT

>30282_30282_2_FGFR2-CCDC6_FGFR2_chr10_123243212_ENST00000369056_CCDC6_chr10_61612460_ENST00000263102_length(amino acids)=1141AA_BP=768
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA
RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEG
HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTN
ELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQE
KLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLS
ESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPS

--------------------------------------------------------------
>30282_30282_3_FGFR2-CCDC6_FGFR2_chr10_123243212_ENST00000369061_CCDC6_chr10_61612460_ENST00000263102_length(transcript)=7391nt_BP=2115nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAATGTATTCATCGAGATTTAGCAGCCAGAAATGTT
TTGGTAACAGAAAACAATGTGATGAAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACCACCAAT
GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATACACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTA
ATGTGGGAGATCTTCACTTTAGGGGGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACACAGAATG
GATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGGCATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAG
TTGGTAGAAGACTTGGATCGAATTCTCACTCTCACAACCAATGAGCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTA
TTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCC
AGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTTCAGGTCAACAAACTGATGAAG
AAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAGATTGACCTTGAAAATACATTG
GAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGAATCCTGCAGGAAAAATTAGAC
CAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATGCGTCACATCAGGTTTTTAAAG
AATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAGTATCTGGAGGAGGAACGTCAC
ATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGTCGACAGCTCTCCGAGAGTGAG
TCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACTGTGTCCAGCCCGATCCCTTAC
ACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTCACGCCACCAACTTCACTGACT
AGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATCACAAGGCCTTCACCACGGAGA
AGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAGCCACCTCCGCCTCCACCTCCG
CCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCACCCCTCCTCCCAGCCTTAATGC
ATGAGCTTAGTCTGAATTTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACGCCAAAGGCTTCCTTCTCTGGCATATTTGGATAT
GACTTATTTGCACTGAGGTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTGTCAGAAATGCAGCCAGTGTTGTGGGTCTACAAC
ACTAACCAGACGACTTTTTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATTCCCTGGCTGGAACCTTCGCTGTTTGGTATTTGG
TATTTCAGCAGCAGTGTGCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTTTAGGTTTGTAAAAGAAAAAGGGATATCTTTTTT
ATATTTTTTTCCATGAATCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCATTATAATAGTGTTTACCAAACATACCAATAATTC
AGCACTACAATTCAGACCTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGATGAATCAGTGCCCAAGACATATTTTCTGTTTAA
CAGAACTTTCTACAGATACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCCATGTCTCTCGTAAAACAGATGGCCCAAAGTAAT
GAATCATGTGGCTGTACCTTCTCCACATAAATGGGATGGATAATTATCGTATATTAAGATGTGATTCTCTTTTTTATCCTTAATGTTAAT
CTACTTAACCTGGCCCCCTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTGGTTTCAATGGCTAATTAGAATGTGTTATTTGAT
TTCTGCTGCAGAAGGCAGTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGTACTTCATTTGTGTTCTCTTAAAATAGAGTTTGA
ACAAATATTTTAAAGGTGCAAAATACCATTAGAAAATACTATTTGAAATGGACATTATCGCATTATCTTGGCATAATGGCCAGAAAATAT
TGTATTGCTTGGCAGAAAAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTGATGGCTGTTCATTTCACCCAGTATAAGCAAGTG
CAGTGTACAAAGAAGTATATTCTGAATACATTATTTCCATTCATTTAGCACAAATAAATCATTTGGTTTCACTTTGCAGTGGAACACTGA
GTCACTCTTTTCTTAACACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGTTTTGTACTTTGGTAGTAAAGTGATTTTTACCAC
CTGTGTTTGCATATTTATATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATATTTTATGACAAGAATGTGTATCTGTTGGATATA
ATCAGAGAACTGAAAAGTAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACAACCATCTCTAATAGCCAACTCTTTATTAAACAC
ACTCCTAAAAATAAGGAACCATGACATTGTAGATATTTAATATTGTACAGTATAGAAACCTCCATTTTTGCCTTCGAATGCATATTTAAG
AGTTAACAGAATGAAAAAAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTTAAGAACTTGAGAGTAAAAGCAACAATAAGATTT
TTTCACCTCTTCCTGCTTCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAGAAACTGTAGGTCTATATAAATTTTATTTATAAT
GTATGTGTAATATACATAATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGCATTTAATCATTGAGGCTTTAGGTTTTTGATGTG
ATCAGACTGGGCCATGTCAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTGGTACATTGCCATTCCAAGGAATTCTGAGAGTAG
GCAAACAAATTTTGCCTTCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATGGTATATGTTTATAAGAATCTTTTATGAGATTAT
AGATTTCAATGCTGTGGATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAATGATCTTCCCTCAGCTTCCTATCGATTTAGTTAC
CTCTTGAAAGCACAAAAATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTTGGAGTGAGCGAACATTTCCTGATAAATGCCTTT
TAGAGATAGGTTCTTGATATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCATTTCACTTCGAAATAAAACACAGCTCCTTCAAA
CAGCACTTTTTCCACATAAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATAGAACAAACACTACTCTTTTGAATTTGATGGTTC
GTGTCCTTTAAAGTGTTTGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCTGCTAGGACAATTTCTTGGCAATTGTCTTACTAC
TAGGGATCAGTAAGATTTAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTATGGGAAGCTGACTTCCCTCAGTCGGGCACTTCTC
ATGGGGGCTGAACATGGTTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTGGATTGGCTCCCAGAAGGCCTTTGTAAAATCAGT
AGCCGTCCTGCAGGCAGGTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTCTTGCAGACAGAGACCCTTGGCTACCACTGTGCT
GCTAATAGGATAAGTACTCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAATTAACTTACCTAATACCTGACACCTCTTTGGGCT
CTGAACTGCTTTCTCTCATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTTGGCAGATAGTGGAAGCCTTTAATTGAACTTACT
CCTTCGTTGACTGAAAGGAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAACCATGGAATGAATGTGTGACCAGAAAGTGGCTTT
GACACCAAGTGCTACTGTCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAATAATTGATAATGTGAATTTTTGTTAATTGTTCAC
TTGTAGGAAAATAGAACATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGCACAAAGCCTTGCTTTTAGAGAATGCCCAATAAG
GCAAGAAAAAGCATAGTAACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGTACAGAAGAAATATTTCTGTGTAACTTGATCTTC
TGTCTAGTACTTGTCTTATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACCAAAGAAATACATAGTAAAACAACCTTTTATTTC
CAAATTGTTAAAGAGCCAGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCCATTGTAAGAGATTAAGGGGTTTCTAGGTTTTTG
GTGATTTTTTGTTTGTTTTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATTTTTTGATTAAAACATACACACAGCTGTTAGCAT
AAAGTCGTGGGGGGCATTTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCCAGGTTGCCTCTCATGAGGCAACTGAAAAAATCC
TGTGTCTTGATAGCATGGGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCTTAACTCGGGTTACTGCACAACTTTAGTTCTTGA
CTTAGTCTGCACCGTCATCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTGGCAAAAACAAAGTTGCAGGCACAACAGTTTAAG
AATGCATTCCTCCAGAAGAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACTTGATTTGGAACTTAGCCTGGAAAGCGAAAGTGG
ACTGTCCAACAGAAAGATGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCCTTTTGCCTCTGCATATCTGTGCACACTGTATGT
TGTTCATGATAGCTTGTCTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAATCTTGACATTCTTGGTCAGAGTTTAGAGAGATG
TAAGACTTTCAATTAATGTCTTATTTACTCCTTTATGTTGATTAGTCTTTGATACATGTGCTGAATCAGAAACCTAAATAAAGATAATTT

>30282_30282_3_FGFR2-CCDC6_FGFR2_chr10_123243212_ENST00000369061_CCDC6_chr10_61612460_ENST00000263102_length(amino acids)=1062AA_BP=689
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEQARAEQEEEFISNTLFKKIQALQKEKETLAV
NYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMD
KLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREM
ERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FGFR2-CCDC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR2-CCDC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGFR2-CCDC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource