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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR2-USP10 (FusionGDB2 ID:30298)

Fusion Gene Summary for FGFR2-USP10

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2-USP10
Fusion gene ID: 30298
HgeneTgene
Gene symbol

FGFR2

USP10

Gene ID

2263

84669

Gene namefibroblast growth factor receptor 2ubiquitin specific peptidase 32
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25NY-REN-60|USP10
Cytomap

10q26.13

17q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
Modification date2020032220200313
UniProtAcc

P21802

.
Ensembl transtripts involved in fusion geneENST00000346997, ENST00000351936, 
ENST00000356226, ENST00000357555, 
ENST00000358487, ENST00000359354, 
ENST00000360144, ENST00000369056, 
ENST00000369059, ENST00000369060, 
ENST00000369061, ENST00000457416, 
ENST00000490349, ENST00000478859, 
ENST00000562743, ENST00000219473, 
ENST00000570191, 
Fusion gene scores* DoF score24 X 20 X 12=576017 X 15 X 9=2295
# samples 3819
** MAII scorelog2(38/5760*10)=-3.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2295*10)=-3.59442282997022
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR2 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR2(123353223)-USP10(84792322), # samples:3
Anticipated loss of major functional domain due to fusion event.FGFR2-USP10 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR2-USP10 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR2-USP10 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
FGFR2-USP10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check buttonFusion gene breakpoints across FGFR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across USP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1424-01AFGFR2chr10

123353223

-USP10chr16

84792322

+
ChimerDB4OVTCGA-24-1424FGFR2chr10

123353222

-USP10chr16

84792321

+


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Fusion Gene ORF analysis for FGFR2-USP10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346997ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000346997ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000351936ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000351936ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000356226ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000356226ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000357555ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000357555ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000358487ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000358487ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000359354ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000359354ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000360144ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000360144ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000369056ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369056ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000369059ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369059ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000369060ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369060ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000369061ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369061ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5CDS-intronENST00000457416ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000457416ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
5UTR-3CDSENST00000490349ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
5UTR-3CDSENST00000490349ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
5UTR-3CDSENST00000490349ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5UTR-3CDSENST00000490349ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
5UTR-intronENST00000490349ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5UTR-intronENST00000490349ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000346997ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000346997ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000346997ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000346997ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000351936ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000351936ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000351936ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000351936ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000356226ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000356226ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000356226ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000356226ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000357555ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000357555ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000357555ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000357555ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000358487ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000358487ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000358487ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000358487ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000359354ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000359354ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000359354ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000359354ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000360144ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000360144ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000360144ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000360144ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369056ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369056ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369056ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369056ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369059ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369059ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369059ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369059ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369060ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369060ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369060ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369060ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369061ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369061ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000369061ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369061ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000457416ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000457416ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
Frame-shiftENST00000457416ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000457416ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
intron-3CDSENST00000478859ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
intron-3CDSENST00000478859ENST00000219473FGFR2chr10

123353222

-USP10chr16

84792321

+
intron-3CDSENST00000478859ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
intron-3CDSENST00000478859ENST00000570191FGFR2chr10

123353222

-USP10chr16

84792321

+
intron-intronENST00000478859ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
intron-intronENST00000478859ENST00000562743FGFR2chr10

123353222

-USP10chr16

84792321

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FGFR2-USP10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGFR2chr10123353222-USP10chr1684792321+0.0001757440.9998242
FGFR2chr10123353222-USP10chr1684792321+0.0001757440.9998242
FGFR2chr10123353222-USP10chr1684792321+0.0001757440.9998242
FGFR2chr10123353222-USP10chr1684792321+0.0001757440.9998242

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGFR2-USP10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:123353223/:84792322)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

.
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FGFR2-USP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FGFR2-USP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR2-USP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGFR2-USP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource