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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGGY-HOOK1 (FusionGDB2 ID:30335)

Fusion Gene Summary for FGGY-HOOK1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGGY-HOOK1
Fusion gene ID: 30335
HgeneTgene
Gene symbol

FGGY

HOOK1

Gene ID

55277

51361

Gene nameFGGY carbohydrate kinase domain containinghook microtubule tethering protein 1
Synonyms-HK1
Cytomap

1p32.1

1p32.1

Type of geneprotein-codingprotein-coding
DescriptionFGGY carbohydrate kinase domain-containing proteinD-ribulokinaseprotein Hook homolog 1h-hook1hHK1hook homolog 1
Modification date2020031320200313
UniProtAcc.

Q9UJC3

Ensembl transtripts involved in fusion geneENST00000474476, ENST00000303721, 
ENST00000371210, ENST00000371212, 
ENST00000371218, 		ENST00000371208, 
ENST00000395561, ENST00000465876, 
Fusion gene scores* DoF score12 X 9 X 5=5403 X 5 X 3=45
# samples 115
** MAII scorelog2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FGGY [Title/Abstract] AND HOOK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHOOK1(60294524)-FGGY(60223603), # samples:3
FGGY(60073582)-HOOK1(60299077), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGGY

GO:0019321

pentose metabolic process

27909055

HgeneFGGY

GO:0046835

carbohydrate phosphorylation

27909055


check buttonFusion gene breakpoints across FGGY (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HOOK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A11A-01AFGGYchr1

60073582

+HOOK1chr1

60299077

+


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Fusion Gene ORF analysis for FGGY-HOOK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000474476ENST00000371208FGGYchr1

60073582

+HOOK1chr1

60299077

+
3UTR-3UTRENST00000474476ENST00000395561FGGYchr1

60073582

+HOOK1chr1

60299077

+
3UTR-3UTRENST00000474476ENST00000465876FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000303721ENST00000395561FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000303721ENST00000465876FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000371210ENST00000395561FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000371210ENST00000465876FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000371212ENST00000395561FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000371212ENST00000465876FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000371218ENST00000395561FGGYchr1

60073582

+HOOK1chr1

60299077

+
5CDS-3UTRENST00000371218ENST00000465876FGGYchr1

60073582

+HOOK1chr1

60299077

+
In-frameENST00000303721ENST00000371208FGGYchr1

60073582

+HOOK1chr1

60299077

+
In-frameENST00000371210ENST00000371208FGGYchr1

60073582

+HOOK1chr1

60299077

+
In-frameENST00000371212ENST00000371208FGGYchr1

60073582

+HOOK1chr1

60299077

+
In-frameENST00000371218ENST00000371208FGGYchr1

60073582

+HOOK1chr1

60299077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371218FGGYchr160073582+ENST00000371208HOOK1chr160299077+652211951423108988
ENST00000303721FGGYchr160073582+ENST00000371208HOOK1chr160299077+651211851323098988
ENST00000371212FGGYchr160073582+ENST00000371208HOOK1chr160299077+61788511042764886
ENST00000371210FGGYchr160073582+ENST00000371208HOOK1chr160299077+55792521052165686

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371218ENST00000371208FGGYchr160073582+HOOK1chr160299077+8.96E-050.99991035
ENST00000303721ENST00000371208FGGYchr160073582+HOOK1chr160299077+8.94E-050.9999106
ENST00000371212ENST00000371208FGGYchr160073582+HOOK1chr160299077+0.0003173930.99968266
ENST00000371210ENST00000371208FGGYchr160073582+HOOK1chr160299077+0.000247870.9997521

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Fusion Genomic Features for FGGY-HOOK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGGYchr160073582+HOOK1chr160299076+0.0083487920.99165124
FGGYchr160073582+HOOK1chr160299076+0.0083487920.99165124

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGGY-HOOK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:60294524/chr1:60223603)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HOOK1

Q9UJC3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHOOK1chr1:60073582chr1:60299077ENST00000371208322169_43491729.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK1chr1:60073582chr1:60299077ENST00000371208322477_65891729.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHOOK1chr1:60073582chr1:60299077ENST0000037120832212_12891729.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for FGGY-HOOK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30335_30335_1_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000303721_HOOK1_chr1_60299077_ENST00000371208_length(transcript)=6512nt_BP=1185nt
GGCTTCTCCAACCCGGCCCGGCCCTTCCTTCCCCTTTCCCGCAGTCGTTGCCTCCTCCTCCCCTGCCTCCTCCTCCCCTTCCTCCTCCTG
GCCGCTTAGTCTCACACCCGCCGGGCCGTTGTTCCCGAGACGTTGTTGAGTCCCCTGTGTCCTCTTCTGGGTGGAGGAACTGCAATGTCT
GGTGGAGAACAGAAACCAGAGAGGTACTATGTGGGTGTGGACGTTGGAACAGGCAGTGTCCGTGCAGCTCTGGTGGACCAGAGTGGGGTC
CTGTTGGCTTTTGCAGACCAGCCAATTAAGAATTGGGAGCCCCAGTTCAACCACCATGAGCAGTCCTCCGAGGACATCTGGGCTGCGTGC
TGTGTTGTCACAAAGAAAGTTGTACAAGGGATTGATTTAAACCAAATTCGAGGACTTGGGTTTGATGCCACGTGTTCTCTGGTTGTTTTG
GATAAGCAGTTTCACCCATTACCAGTCAACCAGGAAGGGGATTCCCATCGAAACGTCATCATGTGGCTGGACCATCGAGCAGTCAGTCAA
GTTAACAGGATCAATGAGACCAAGCACAGTGTCCTCCAGTACGTCGGGGGGGTGATGTCTGTGGAAATGCAGGCCCCGAAACTTCTGTGG
CTGAAAGAGAACTTGAGAGAGATTTGCTGGGATAAGGCGGGACATTTCTTTGATCTCCCGGACTTCTTATCGTGGAAGGCAACAGGTGTC
ACAGCACGGTCTCTCTGCTCCCTGGTGTGTAAGTGGACATATTCAGCAGAGAAAGGCTGGGACGACAGTTTCTGGAAAATGATTGGTTTG
GAAGACTTTGTTGCAGATAATTACAGCAAAATAGGAAACCAAGTGCTACCTCCTGGAGCTTCTCTTGGAAATGGGCTCACACCAGAGGCA
GCAAGAGACCTTGGCCTTCTCCCTGGGATTGCGGTCGCAGCTTCACTCATTGATGCCCATGCAGGAGGACTAGGAGTGATTGGGGCAGAT
GTGAGAGGGCACGGCCTCATCTGTGAGGGGCAGCCAGTGACGTCACGGCTGGCTGTCATCTGTGGAACGTCTTCTTGTCACATGGGGATC
AGCAAAGACCCGATTTTTGTACCAGGCGTCTGGGGGCCTTATTTCTCAGCCATGGTACCTGGGTTCTGGCTGAATGAAGGTGGTCAGAGC
GTTACTGGAAAATTGTTTTTGGGGCAGCAGATTTCAGAAGCACTTATCCCTGATTTAAACCAAATAACCGAATGTTCAGATCCAGTGGAG
CTTGGGAGGTTGCTCCAGCTTATTTTAGGTTGTGCGATCAACTGTGAAAAGAAGCAAGAACATATTCAAAATATAATGACACTGGAAGAG
TCTGTTCAACATGTGGTCATGACTGCTATTCAAGAGTTGATGAGTAAAGAAATATTGAGCTCTCCTCCAAATGATGCTGTTGGAGAATTG
GAGCAACAGCTTAAAAGAGCCTTGGAAGAACTTCAGGAAGCACTAGCAGAAAAAGAAGAGCTGAGGCAAAGATGTGAAGAATTGGATATG
CAGGTGACTACACTTCAAGATGAAAAGAATTCACTGGTTTCTGAAAATGAGATGATGAATGAAAAACTTGACCAGTTGGATGGCTCTTTT
GATGATCCAAACACAGTGGTTGCAAAAAAGTATTTTCATGCACAATTACAACTAGAACAATTACAGGAAGAAAACTTCAGGCTTGAAGCT
GCAAAAGATGATTACCGTGTTCACTGTGAAGAACTTGAAAAGCAGCTAATCGAATTCCAGCATAGGAATGATGAATTGACTAGTCTTGCA
GAAGAAACAAGAGCCCTGAAAGATGAAATAGATGTTCTTAGGGCTACCTCTGATAAAGCAAATAAACTGGAGTCAACAGTTGAGATATAT
CGTCAGAAGCTACAAGATCTGAATGACCTTCGCAAGCAGGTGAAAACTTTACAGGAAACCAACATGATGTATATGCATAATACAGTCAGC
TTAGAAGAAGAATTAAAAAAAGCAAATGCAGCACGTACACAATTAGAAACATACAAAAGGCAGGTTCAAGATCTTCATGTTAAACTTTCC
TCCGAATCCAAGAGGGCAGACACACTAGCGTTTGAAATGAAGCGGCTTGAAGAAAAACATGAAGCTTTACTTAAGGAAAAAGAGAGACTA
ATTGAGCAGCGTGATACTTTGAAAGAAACAAATGAAGAGCTTCGATGTTCACAAGTACAACAGGACCACCTAAACCAAACAGATGCATCT
GCTACAAAAAGTTATGAGAATCTTGCTGCTGAGATTATGCCAGTGGAATATAGGGAGGTGTTTATTCGACTGCAACATGAAAATAAGATG
CTTCGCTTACAGCAAGAAGGCTCTGAGAATGAACGTATTGAGGAACTTCAGGAGCAGCTAGAACAGAAACACCGTAAAATGAATGAACTG
GAAACTGAGCAGAGGCTGAGCAAAGAGCGTATTAGAGAATTGCAGCAGCAGATTGAGGACCTCCAGAAATCTTTACAGGAACAAGGTTCC
AAGTCTGAAGGCGAAAGTTCCAGCAAATTAAAGCAGAAGTTGGAAGCTCATATGGAAAAACTCACAGAGGTCCATGAAGAATTACAGAAG
AAACAAGAACTCATTGAAGATCTTCAGCCAGATATAAATCAAAATGTACAAAAGATCAATGAACTTGAAGCTGCTCTTCAGAAGAAAGAT
GAAGATATGAAAGCAATGGAGGAAAGATATAAAATGTACTTGGAGAAAGCCAGAAATGTAATAAAAACTTTGGATCCCAAGTTAAATCCA
GCATCAGCTGAAATAATGCTACTAAGAAAGCAGTTGGCAGAGAAAGAGAGAAGAATTGAGATTCTGGAGAGTGAATGCAAAGTAGCAAAA
TTCCGTGATTATGAAGAAAAACTCATTGTTTCTGCGTGGTATAATAAGAGTCTAGCATTCCAGAAACTGGGGATGGAATCTAGACTTGTG
AGCGGCGGTGGTGCCTGCAGTGACACTGGTGCGTGCACTCCTGCGCGGTCTTTCTTAGCGCAGCAACGGCACATCACCAACACCAGAAGA
AATCTCTCTGTTAAAGTCCCTGCTACAACATCTGATTAAACTGCAAAAAAAACAAAACAAAACAAAAAAACCACATAAAATAGAAGTGTC
CTTAAAATATTTTGTACCTTTCAACTAACTACCAGATTGAAAAAGAGTTTATGATGCGGGATATCAGGTATTTTAAAATCAACATGCATC
AAATTAATTTTGCCAGTTGACTTTAAAAACAAATTATAGAATTAGCCATCTCTCTGAGGGAGCACATTTGAATAATTGGAGATGCAGTTA
TACACACATTTCAAACAAACATTTGTCTTTTGAGAGTATTATAATTTCAAATTGGCCTTGTATATTTTAGTTAAATGTTTTCAGTTGTAT
TAGTAACTTAATTAATTTTCAATAGCTATTCAGTAATACTTAATCTTAGAACATTAATTGGATTTGTTTAATCTTTTTTTGTTTTTTGTT
GATTTATATGAAAACAGTCTTGAGGCAGGGACATGGAGAACTATGCAAGGGTGATTTCTTTGACTTAATATATACAAGGCTTTACTTCTG
TCCCCTAATTCTTCCATTGAATGTGTACCTCTACCTTGTCATGTCATGGAAGATACAACATTTGGAAGATCTGACAATTGGAATGACTTT
GGAATAATAAAATTGACTAATTGGAAATTTTGCATATTCTGAAAATCTAATCTCATAGTTCTAATTTGTACCTATGGCAAATAAGGGCTT
CTGGACATCATGTTTAAAATGTTAAGCATAAGAAATAAACTGACATTTGTAATAGGTGACTTTCTGATGGAAAGCAAGCTATATATATAT
ATATATATATATATATATATATATATATACTTTTTGTGAAATGTCTATATACTTTTTAAGGTAATTAATGAAGATTTCAGTTATTGCTTT
TAAGCATAAAGTTGTATTTAGCTTCTGCTGAAAAATTGTATCATATAATAATTTTGCTTCATTGAAAAGGGATGTTGCAGTGATGAAACA
AGGTGGGATCAGTTTGATTTTGTTTACTTATTAAGGAGTTTATCTTGGGCTCAGTTTGTGGTATTCAGTTCGTTTCTGCCCAAAGCTCTT
ATTTTCAGAGGTGTTACTTTTGAACTTTTGGGGTCATTTTTAAAAGTTAGCACTTTTGAATTTTAGTTGTGTTAAATATGTGCTGTCGTA
TATCATAGCCATGAGCCATATATGACAATTTAAATTTAATTAATTATAAACTCAGTCTCTTGGTTGCACCAGCCACATTTCAGATGCTCA
ATAGCCACATGTGGCTAGTGGGTACCATATTGGACAGGGCAGCTATAGAATATTTCCATCATTGCAGAAAGTTCTATTGGATAGTACCAT
AATCTTTTTATAGTAACTTGGAAATACTATTTGATATTAGATGTTAGACCACAAAAAGAAGAAAAATGTTAGGACTATTTCAGATATAAA
AAGGAACTGAATTGTGACATAATTAGCATCTTACATTCCATACAGTTGAATACCTTATGCTGTGACAACCATAGTTAATCATTTCAGTGC
TGTTCAACATACATACCTATCAGCAGTGTGTTTAGACCAGGGGTCTGCAAACTTTCTGTGAATGGACAAAGAGTAAATACTTTAGTAAAT
GTCTTAGGCTTTGTGGCCTACATGATCTTTGTTGCAAGTACTCAACTCTGCCATTATAGAGTTAAAGCAGCCATACACAATATATAAACA
AAATGGGCATAGTTGTATTTCAGTAAAACTTTATTTACAAAGACAGGCGGTAGGCCAGATTTGGCTTGCATGCTGTAGAGCTGTGGTCTA
AATTTTATTCATAGACTTTCTTTGCAAATACAGTGTGAGTATTGTTCCATTTACAGTATTATTATTTTTTAGATACCTGGTTTTTAGATT
CTTGCCTGGTAACTTTTTACTGAAAATACAAGAATTTCGTACTGCATTTGCATCTCCGAGATTAGGGAGCACCTGTCAGGATATGTTGTT
CTATCAGGGTTACTTCTGTTGACTACCTCTTAGATTTTGATACAGTTATATTGTTGAGTTTCATTTTCATATATTCTTGTAGTGTCTGCT
TGCCTGTGACTTCTGGTAAAATAAAATAAGCCTTTGAAAATATTTTAGCATGGTATTTAACATTTTCTAAATATTATGGCATTTTGACAT
ATTTTAGTCAGCGAAGACATCTGCCCCTTTGGTGTTTCTACTTGCTTATGATTGAGATTTTACAAGCCCTTCAAACTCCGTTTTAAAGGA
ATTTATTGTAAAACATTAACTTTAATAAATTAGTGTTTTCACAGATCAGATCATTATACTTGGAACTTCTAAATCATGCAATTTCTGAAT
AAGGACATAAGGCTAGATTCATTTTTCTTAATAGAGAAAAAGGAAATTTCTGATTTATCACTTTTCTAGTTGATAAGTAGGATTCAAAAC
GTTTGATATGTAAGTATTTATATAAGACTAATGTAATTTAAAGTTCTGTATTATTGTGATTAATCATACAGAAATTCAGGAACTGATCAG
AAGTGAGATTCTTTTCCACATCTGGTTAATGTAGTGAGTTGACACCCTGTGGGTGGTAAAGCATTATAAACATTTCATCTTGAACCATGA
TTTATACACATCTGTGTTATAAGGGAGGCTTGAGTACATATACCAATGAAGAGATATTCAGCATTTGTCTATTTGATAAGGAATTAAATG
TCCTAGTGATTATAAAGTAAAACCACAGACCAATTTGCAAATGATCTTCAATGTTAAGCACTTGCTCTAAGATTAAAATTCCTTTTCTTT
TTAAGGTTAAGGGTGTGTACGTATGGCAGTGATGTCTATGTTGAGATTAACTTATGTATTGAGGAAAATTTGAAGTTTATTTTTTCGATG
AATAAGGCTGTCAAATGATTTAGTATAGATTAATGACATCTTTTTTAGAAATATTAAAGTGAGTATTCCTCATTATGTCATCATTTCTGA
TAATTAGAGTGCTAATTTGAATGTTAGATAATGTTTCCACATCTATACCTATTTCTTTCTAGGGCACTTCTGACCCTGGGGCTTGGGGAT
GGCCTTTAGGCCACAGTAGTGTCTGTGTTAAGTTCACTAAATGTGTATTTAATGAGAAACATTCCTATGTAAAAATGTGTGTATGTGAAC
GTATGCATACATTTTTATTGTGCACCTGTACATTGTGAAGAAGTAGTTTGGAAATTTGTAAAGCACAAACCATAAAAGAGTGTGGAGTTA
TTAAATGATGTAGCACAAATGTAATGTTTAGCTTATAAAAGGTCCTTTCTATTTTCTATGGCAAAGACTTTGACACTTGAAAAATAAAAC
CAATATTTGATTTATTTTTGTAAGTATTTAGGATATTATTTTAAATAAATGATTGTCCATTATCAATATAATAGTTGTGAAATGATTTAA

>30335_30335_1_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000303721_HOOK1_chr1_60299077_ENST00000371208_length(amino acids)=988AA_BP=1
MLSPLCPLLGGGTAMSGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWAACCVVTKKVVQGIDLN
QIRGLGFDATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAVSQVNRINETKHSVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAG
HFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFVADNYSKIGNQVLPPGASLGNGLTPEAARDLGLLPGIAVAA
SLIDAHAGGLGVIGADVRGHGLICEGQPVTSRLAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLFLGQQISEA
LIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA
LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEK
QLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQ
LETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMP
VEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL
EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAE

--------------------------------------------------------------
>30335_30335_2_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000371210_HOOK1_chr1_60299077_ENST00000371208_length(transcript)=5579nt_BP=252nt
AAAGCAAAATCTGAGCAGGCTTCCGAGGTTTCCTATGCAGGAGTGATTGGGGCAGATGTGAGAGGGCACGGCCTCATCTGTGAGGGGCAG
CCAGTGACGTCACGGCTGGCTGTCATCTGTGGAACGTCTTCTTGTCACATGGGGATCAGCAAAGACCCGATTTTTGTACCAGGCGTCTGG
GGGCCTTATTTCTCAGCCATGGTACCTGGGTTCTGGCTGAATGAAGGTGGTCAGAGCGTTACTGGAAAATTGTTTTTGGGGCAGCAGATT
TCAGAAGCACTTATCCCTGATTTAAACCAAATAACCGAATGTTCAGATCCAGTGGAGCTTGGGAGGTTGCTCCAGCTTATTTTAGGTTGT
GCGATCAACTGTGAAAAGAAGCAAGAACATATTCAAAATATAATGACACTGGAAGAGTCTGTTCAACATGTGGTCATGACTGCTATTCAA
GAGTTGATGAGTAAAGAAATATTGAGCTCTCCTCCAAATGATGCTGTTGGAGAATTGGAGCAACAGCTTAAAAGAGCCTTGGAAGAACTT
CAGGAAGCACTAGCAGAAAAAGAAGAGCTGAGGCAAAGATGTGAAGAATTGGATATGCAGGTGACTACACTTCAAGATGAAAAGAATTCA
CTGGTTTCTGAAAATGAGATGATGAATGAAAAACTTGACCAGTTGGATGGCTCTTTTGATGATCCAAACACAGTGGTTGCAAAAAAGTAT
TTTCATGCACAATTACAACTAGAACAATTACAGGAAGAAAACTTCAGGCTTGAAGCTGCAAAAGATGATTACCGTGTTCACTGTGAAGAA
CTTGAAAAGCAGCTAATCGAATTCCAGCATAGGAATGATGAATTGACTAGTCTTGCAGAAGAAACAAGAGCCCTGAAAGATGAAATAGAT
GTTCTTAGGGCTACCTCTGATAAAGCAAATAAACTGGAGTCAACAGTTGAGATATATCGTCAGAAGCTACAAGATCTGAATGACCTTCGC
AAGCAGGTGAAAACTTTACAGGAAACCAACATGATGTATATGCATAATACAGTCAGCTTAGAAGAAGAATTAAAAAAAGCAAATGCAGCA
CGTACACAATTAGAAACATACAAAAGGCAGGTTCAAGATCTTCATGTTAAACTTTCCTCCGAATCCAAGAGGGCAGACACACTAGCGTTT
GAAATGAAGCGGCTTGAAGAAAAACATGAAGCTTTACTTAAGGAAAAAGAGAGACTAATTGAGCAGCGTGATACTTTGAAAGAAACAAAT
GAAGAGCTTCGATGTTCACAAGTACAACAGGACCACCTAAACCAAACAGATGCATCTGCTACAAAAAGTTATGAGAATCTTGCTGCTGAG
ATTATGCCAGTGGAATATAGGGAGGTGTTTATTCGACTGCAACATGAAAATAAGATGCTTCGCTTACAGCAAGAAGGCTCTGAGAATGAA
CGTATTGAGGAACTTCAGGAGCAGCTAGAACAGAAACACCGTAAAATGAATGAACTGGAAACTGAGCAGAGGCTGAGCAAAGAGCGTATT
AGAGAATTGCAGCAGCAGATTGAGGACCTCCAGAAATCTTTACAGGAACAAGGTTCCAAGTCTGAAGGCGAAAGTTCCAGCAAATTAAAG
CAGAAGTTGGAAGCTCATATGGAAAAACTCACAGAGGTCCATGAAGAATTACAGAAGAAACAAGAACTCATTGAAGATCTTCAGCCAGAT
ATAAATCAAAATGTACAAAAGATCAATGAACTTGAAGCTGCTCTTCAGAAGAAAGATGAAGATATGAAAGCAATGGAGGAAAGATATAAA
ATGTACTTGGAGAAAGCCAGAAATGTAATAAAAACTTTGGATCCCAAGTTAAATCCAGCATCAGCTGAAATAATGCTACTAAGAAAGCAG
TTGGCAGAGAAAGAGAGAAGAATTGAGATTCTGGAGAGTGAATGCAAAGTAGCAAAATTCCGTGATTATGAAGAAAAACTCATTGTTTCT
GCGTGGTATAATAAGAGTCTAGCATTCCAGAAACTGGGGATGGAATCTAGACTTGTGAGCGGCGGTGGTGCCTGCAGTGACACTGGTGCG
TGCACTCCTGCGCGGTCTTTCTTAGCGCAGCAACGGCACATCACCAACACCAGAAGAAATCTCTCTGTTAAAGTCCCTGCTACAACATCT
GATTAAACTGCAAAAAAAACAAAACAAAACAAAAAAACCACATAAAATAGAAGTGTCCTTAAAATATTTTGTACCTTTCAACTAACTACC
AGATTGAAAAAGAGTTTATGATGCGGGATATCAGGTATTTTAAAATCAACATGCATCAAATTAATTTTGCCAGTTGACTTTAAAAACAAA
TTATAGAATTAGCCATCTCTCTGAGGGAGCACATTTGAATAATTGGAGATGCAGTTATACACACATTTCAAACAAACATTTGTCTTTTGA
GAGTATTATAATTTCAAATTGGCCTTGTATATTTTAGTTAAATGTTTTCAGTTGTATTAGTAACTTAATTAATTTTCAATAGCTATTCAG
TAATACTTAATCTTAGAACATTAATTGGATTTGTTTAATCTTTTTTTGTTTTTTGTTGATTTATATGAAAACAGTCTTGAGGCAGGGACA
TGGAGAACTATGCAAGGGTGATTTCTTTGACTTAATATATACAAGGCTTTACTTCTGTCCCCTAATTCTTCCATTGAATGTGTACCTCTA
CCTTGTCATGTCATGGAAGATACAACATTTGGAAGATCTGACAATTGGAATGACTTTGGAATAATAAAATTGACTAATTGGAAATTTTGC
ATATTCTGAAAATCTAATCTCATAGTTCTAATTTGTACCTATGGCAAATAAGGGCTTCTGGACATCATGTTTAAAATGTTAAGCATAAGA
AATAAACTGACATTTGTAATAGGTGACTTTCTGATGGAAAGCAAGCTATATATATATATATATATATATATATATATATATATATACTTT
TTGTGAAATGTCTATATACTTTTTAAGGTAATTAATGAAGATTTCAGTTATTGCTTTTAAGCATAAAGTTGTATTTAGCTTCTGCTGAAA
AATTGTATCATATAATAATTTTGCTTCATTGAAAAGGGATGTTGCAGTGATGAAACAAGGTGGGATCAGTTTGATTTTGTTTACTTATTA
AGGAGTTTATCTTGGGCTCAGTTTGTGGTATTCAGTTCGTTTCTGCCCAAAGCTCTTATTTTCAGAGGTGTTACTTTTGAACTTTTGGGG
TCATTTTTAAAAGTTAGCACTTTTGAATTTTAGTTGTGTTAAATATGTGCTGTCGTATATCATAGCCATGAGCCATATATGACAATTTAA
ATTTAATTAATTATAAACTCAGTCTCTTGGTTGCACCAGCCACATTTCAGATGCTCAATAGCCACATGTGGCTAGTGGGTACCATATTGG
ACAGGGCAGCTATAGAATATTTCCATCATTGCAGAAAGTTCTATTGGATAGTACCATAATCTTTTTATAGTAACTTGGAAATACTATTTG
ATATTAGATGTTAGACCACAAAAAGAAGAAAAATGTTAGGACTATTTCAGATATAAAAAGGAACTGAATTGTGACATAATTAGCATCTTA
CATTCCATACAGTTGAATACCTTATGCTGTGACAACCATAGTTAATCATTTCAGTGCTGTTCAACATACATACCTATCAGCAGTGTGTTT
AGACCAGGGGTCTGCAAACTTTCTGTGAATGGACAAAGAGTAAATACTTTAGTAAATGTCTTAGGCTTTGTGGCCTACATGATCTTTGTT
GCAAGTACTCAACTCTGCCATTATAGAGTTAAAGCAGCCATACACAATATATAAACAAAATGGGCATAGTTGTATTTCAGTAAAACTTTA
TTTACAAAGACAGGCGGTAGGCCAGATTTGGCTTGCATGCTGTAGAGCTGTGGTCTAAATTTTATTCATAGACTTTCTTTGCAAATACAG
TGTGAGTATTGTTCCATTTACAGTATTATTATTTTTTAGATACCTGGTTTTTAGATTCTTGCCTGGTAACTTTTTACTGAAAATACAAGA
ATTTCGTACTGCATTTGCATCTCCGAGATTAGGGAGCACCTGTCAGGATATGTTGTTCTATCAGGGTTACTTCTGTTGACTACCTCTTAG
ATTTTGATACAGTTATATTGTTGAGTTTCATTTTCATATATTCTTGTAGTGTCTGCTTGCCTGTGACTTCTGGTAAAATAAAATAAGCCT
TTGAAAATATTTTAGCATGGTATTTAACATTTTCTAAATATTATGGCATTTTGACATATTTTAGTCAGCGAAGACATCTGCCCCTTTGGT
GTTTCTACTTGCTTATGATTGAGATTTTACAAGCCCTTCAAACTCCGTTTTAAAGGAATTTATTGTAAAACATTAACTTTAATAAATTAG
TGTTTTCACAGATCAGATCATTATACTTGGAACTTCTAAATCATGCAATTTCTGAATAAGGACATAAGGCTAGATTCATTTTTCTTAATA
GAGAAAAAGGAAATTTCTGATTTATCACTTTTCTAGTTGATAAGTAGGATTCAAAACGTTTGATATGTAAGTATTTATATAAGACTAATG
TAATTTAAAGTTCTGTATTATTGTGATTAATCATACAGAAATTCAGGAACTGATCAGAAGTGAGATTCTTTTCCACATCTGGTTAATGTA
GTGAGTTGACACCCTGTGGGTGGTAAAGCATTATAAACATTTCATCTTGAACCATGATTTATACACATCTGTGTTATAAGGGAGGCTTGA
GTACATATACCAATGAAGAGATATTCAGCATTTGTCTATTTGATAAGGAATTAAATGTCCTAGTGATTATAAAGTAAAACCACAGACCAA
TTTGCAAATGATCTTCAATGTTAAGCACTTGCTCTAAGATTAAAATTCCTTTTCTTTTTAAGGTTAAGGGTGTGTACGTATGGCAGTGAT
GTCTATGTTGAGATTAACTTATGTATTGAGGAAAATTTGAAGTTTATTTTTTCGATGAATAAGGCTGTCAAATGATTTAGTATAGATTAA
TGACATCTTTTTTAGAAATATTAAAGTGAGTATTCCTCATTATGTCATCATTTCTGATAATTAGAGTGCTAATTTGAATGTTAGATAATG
TTTCCACATCTATACCTATTTCTTTCTAGGGCACTTCTGACCCTGGGGCTTGGGGATGGCCTTTAGGCCACAGTAGTGTCTGTGTTAAGT
TCACTAAATGTGTATTTAATGAGAAACATTCCTATGTAAAAATGTGTGTATGTGAACGTATGCATACATTTTTATTGTGCACCTGTACAT
TGTGAAGAAGTAGTTTGGAAATTTGTAAAGCACAAACCATAAAAGAGTGTGGAGTTATTAAATGATGTAGCACAAATGTAATGTTTAGCT
TATAAAAGGTCCTTTCTATTTTCTATGGCAAAGACTTTGACACTTGAAAAATAAAACCAATATTTGATTTATTTTTGTAAGTATTTAGGA

>30335_30335_2_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000371210_HOOK1_chr1_60299077_ENST00000371208_length(amino acids)=686AA_BP=1
MAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCE
KKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSEN
EMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRAT
SDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRL
EEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEEL
QEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNV
QKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWYNK

--------------------------------------------------------------
>30335_30335_3_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000371212_HOOK1_chr1_60299077_ENST00000371208_length(transcript)=6178nt_BP=851nt
ATGATCGCATGGAGAATGGATTTTGTTGCTTTATCTGATATTGTCCTCAGCTCCTCCTGAATTTGCCGAGATCTTACAGCAGTCAGTAAG
GTGGAGGAACTGCAATGTCTGGTGGAGAACAGAAACCAGAGAGGTACTATGTGGGTGTGGACGTTGGAACAGGCAGTGTCCGTGCAGCTC
TGGTGGACCAGAGTGGGGTCCTGTTGGCTTTTGCAGACCAGCCAATTAAGAATTGGGAGCCCCAGTTCAACCACCATGAGCAGTCCTCCG
AGGACATCTGGGCTGCGTGCTGTGTTGTCACAAAGAACTTGAGAGAGATTTGCTGGGATAAGGCGGGACATTTCTTTGATCTCCCGGACT
TCTTATCGTGGAAGGCAACAGGTGTCACAGCACGGTCTCTCTGCTCCCTGGTGTGTAAGTGGACATATTCAGCAGAGAAAGGCTGGGACG
ACAGTTTCTGGAAAATGATTGGTTTGGAAGACTTTGTTGCAGATAATTACAGCAAAATAGGAAACCAAGTGCTACCTCCTGGAGCTTCTC
TTGGAAATGGGCTCACACCAGAGGCAGCAAGAGACCTTGGCCTTCTCCCTGGGATTGCGGTCGCAGCTTCACTCATTGATGCCCATGCAG
GAGGACTAGGAGTGATTGGGGCAGATGTGAGAGGGCACGGCCTCATCTGTGAGGGGCAGCCAGTGACGTCACGGCTGGCTGTCATCTGTG
GAACGTCTTCTTGTCACATGGGGATCAGCAAAGACCCGATTTTTGTACCAGGCGTCTGGGGGCCTTATTTCTCAGCCATGGTACCTGGGT
TCTGGCTGAATGAAGGTGGTCAGAGCGTTACTGGAAAATTGTTTTTGGGGCAGCAGATTTCAGAAGCACTTATCCCTGATTTAAACCAAA
TAACCGAATGTTCAGATCCAGTGGAGCTTGGGAGGTTGCTCCAGCTTATTTTAGGTTGTGCGATCAACTGTGAAAAGAAGCAAGAACATA
TTCAAAATATAATGACACTGGAAGAGTCTGTTCAACATGTGGTCATGACTGCTATTCAAGAGTTGATGAGTAAAGAAATATTGAGCTCTC
CTCCAAATGATGCTGTTGGAGAATTGGAGCAACAGCTTAAAAGAGCCTTGGAAGAACTTCAGGAAGCACTAGCAGAAAAAGAAGAGCTGA
GGCAAAGATGTGAAGAATTGGATATGCAGGTGACTACACTTCAAGATGAAAAGAATTCACTGGTTTCTGAAAATGAGATGATGAATGAAA
AACTTGACCAGTTGGATGGCTCTTTTGATGATCCAAACACAGTGGTTGCAAAAAAGTATTTTCATGCACAATTACAACTAGAACAATTAC
AGGAAGAAAACTTCAGGCTTGAAGCTGCAAAAGATGATTACCGTGTTCACTGTGAAGAACTTGAAAAGCAGCTAATCGAATTCCAGCATA
GGAATGATGAATTGACTAGTCTTGCAGAAGAAACAAGAGCCCTGAAAGATGAAATAGATGTTCTTAGGGCTACCTCTGATAAAGCAAATA
AACTGGAGTCAACAGTTGAGATATATCGTCAGAAGCTACAAGATCTGAATGACCTTCGCAAGCAGGTGAAAACTTTACAGGAAACCAACA
TGATGTATATGCATAATACAGTCAGCTTAGAAGAAGAATTAAAAAAAGCAAATGCAGCACGTACACAATTAGAAACATACAAAAGGCAGG
TTCAAGATCTTCATGTTAAACTTTCCTCCGAATCCAAGAGGGCAGACACACTAGCGTTTGAAATGAAGCGGCTTGAAGAAAAACATGAAG
CTTTACTTAAGGAAAAAGAGAGACTAATTGAGCAGCGTGATACTTTGAAAGAAACAAATGAAGAGCTTCGATGTTCACAAGTACAACAGG
ACCACCTAAACCAAACAGATGCATCTGCTACAAAAAGTTATGAGAATCTTGCTGCTGAGATTATGCCAGTGGAATATAGGGAGGTGTTTA
TTCGACTGCAACATGAAAATAAGATGCTTCGCTTACAGCAAGAAGGCTCTGAGAATGAACGTATTGAGGAACTTCAGGAGCAGCTAGAAC
AGAAACACCGTAAAATGAATGAACTGGAAACTGAGCAGAGGCTGAGCAAAGAGCGTATTAGAGAATTGCAGCAGCAGATTGAGGACCTCC
AGAAATCTTTACAGGAACAAGGTTCCAAGTCTGAAGGCGAAAGTTCCAGCAAATTAAAGCAGAAGTTGGAAGCTCATATGGAAAAACTCA
CAGAGGTCCATGAAGAATTACAGAAGAAACAAGAACTCATTGAAGATCTTCAGCCAGATATAAATCAAAATGTACAAAAGATCAATGAAC
TTGAAGCTGCTCTTCAGAAGAAAGATGAAGATATGAAAGCAATGGAGGAAAGATATAAAATGTACTTGGAGAAAGCCAGAAATGTAATAA
AAACTTTGGATCCCAAGTTAAATCCAGCATCAGCTGAAATAATGCTACTAAGAAAGCAGTTGGCAGAGAAAGAGAGAAGAATTGAGATTC
TGGAGAGTGAATGCAAAGTAGCAAAATTCCGTGATTATGAAGAAAAACTCATTGTTTCTGCGTGGTATAATAAGAGTCTAGCATTCCAGA
AACTGGGGATGGAATCTAGACTTGTGAGCGGCGGTGGTGCCTGCAGTGACACTGGTGCGTGCACTCCTGCGCGGTCTTTCTTAGCGCAGC
AACGGCACATCACCAACACCAGAAGAAATCTCTCTGTTAAAGTCCCTGCTACAACATCTGATTAAACTGCAAAAAAAACAAAACAAAACA
AAAAAACCACATAAAATAGAAGTGTCCTTAAAATATTTTGTACCTTTCAACTAACTACCAGATTGAAAAAGAGTTTATGATGCGGGATAT
CAGGTATTTTAAAATCAACATGCATCAAATTAATTTTGCCAGTTGACTTTAAAAACAAATTATAGAATTAGCCATCTCTCTGAGGGAGCA
CATTTGAATAATTGGAGATGCAGTTATACACACATTTCAAACAAACATTTGTCTTTTGAGAGTATTATAATTTCAAATTGGCCTTGTATA
TTTTAGTTAAATGTTTTCAGTTGTATTAGTAACTTAATTAATTTTCAATAGCTATTCAGTAATACTTAATCTTAGAACATTAATTGGATT
TGTTTAATCTTTTTTTGTTTTTTGTTGATTTATATGAAAACAGTCTTGAGGCAGGGACATGGAGAACTATGCAAGGGTGATTTCTTTGAC
TTAATATATACAAGGCTTTACTTCTGTCCCCTAATTCTTCCATTGAATGTGTACCTCTACCTTGTCATGTCATGGAAGATACAACATTTG
GAAGATCTGACAATTGGAATGACTTTGGAATAATAAAATTGACTAATTGGAAATTTTGCATATTCTGAAAATCTAATCTCATAGTTCTAA
TTTGTACCTATGGCAAATAAGGGCTTCTGGACATCATGTTTAAAATGTTAAGCATAAGAAATAAACTGACATTTGTAATAGGTGACTTTC
TGATGGAAAGCAAGCTATATATATATATATATATATATATATATATATATATATACTTTTTGTGAAATGTCTATATACTTTTTAAGGTAA
TTAATGAAGATTTCAGTTATTGCTTTTAAGCATAAAGTTGTATTTAGCTTCTGCTGAAAAATTGTATCATATAATAATTTTGCTTCATTG
AAAAGGGATGTTGCAGTGATGAAACAAGGTGGGATCAGTTTGATTTTGTTTACTTATTAAGGAGTTTATCTTGGGCTCAGTTTGTGGTAT
TCAGTTCGTTTCTGCCCAAAGCTCTTATTTTCAGAGGTGTTACTTTTGAACTTTTGGGGTCATTTTTAAAAGTTAGCACTTTTGAATTTT
AGTTGTGTTAAATATGTGCTGTCGTATATCATAGCCATGAGCCATATATGACAATTTAAATTTAATTAATTATAAACTCAGTCTCTTGGT
TGCACCAGCCACATTTCAGATGCTCAATAGCCACATGTGGCTAGTGGGTACCATATTGGACAGGGCAGCTATAGAATATTTCCATCATTG
CAGAAAGTTCTATTGGATAGTACCATAATCTTTTTATAGTAACTTGGAAATACTATTTGATATTAGATGTTAGACCACAAAAAGAAGAAA
AATGTTAGGACTATTTCAGATATAAAAAGGAACTGAATTGTGACATAATTAGCATCTTACATTCCATACAGTTGAATACCTTATGCTGTG
ACAACCATAGTTAATCATTTCAGTGCTGTTCAACATACATACCTATCAGCAGTGTGTTTAGACCAGGGGTCTGCAAACTTTCTGTGAATG
GACAAAGAGTAAATACTTTAGTAAATGTCTTAGGCTTTGTGGCCTACATGATCTTTGTTGCAAGTACTCAACTCTGCCATTATAGAGTTA
AAGCAGCCATACACAATATATAAACAAAATGGGCATAGTTGTATTTCAGTAAAACTTTATTTACAAAGACAGGCGGTAGGCCAGATTTGG
CTTGCATGCTGTAGAGCTGTGGTCTAAATTTTATTCATAGACTTTCTTTGCAAATACAGTGTGAGTATTGTTCCATTTACAGTATTATTA
TTTTTTAGATACCTGGTTTTTAGATTCTTGCCTGGTAACTTTTTACTGAAAATACAAGAATTTCGTACTGCATTTGCATCTCCGAGATTA
GGGAGCACCTGTCAGGATATGTTGTTCTATCAGGGTTACTTCTGTTGACTACCTCTTAGATTTTGATACAGTTATATTGTTGAGTTTCAT
TTTCATATATTCTTGTAGTGTCTGCTTGCCTGTGACTTCTGGTAAAATAAAATAAGCCTTTGAAAATATTTTAGCATGGTATTTAACATT
TTCTAAATATTATGGCATTTTGACATATTTTAGTCAGCGAAGACATCTGCCCCTTTGGTGTTTCTACTTGCTTATGATTGAGATTTTACA
AGCCCTTCAAACTCCGTTTTAAAGGAATTTATTGTAAAACATTAACTTTAATAAATTAGTGTTTTCACAGATCAGATCATTATACTTGGA
ACTTCTAAATCATGCAATTTCTGAATAAGGACATAAGGCTAGATTCATTTTTCTTAATAGAGAAAAAGGAAATTTCTGATTTATCACTTT
TCTAGTTGATAAGTAGGATTCAAAACGTTTGATATGTAAGTATTTATATAAGACTAATGTAATTTAAAGTTCTGTATTATTGTGATTAAT
CATACAGAAATTCAGGAACTGATCAGAAGTGAGATTCTTTTCCACATCTGGTTAATGTAGTGAGTTGACACCCTGTGGGTGGTAAAGCAT
TATAAACATTTCATCTTGAACCATGATTTATACACATCTGTGTTATAAGGGAGGCTTGAGTACATATACCAATGAAGAGATATTCAGCAT
TTGTCTATTTGATAAGGAATTAAATGTCCTAGTGATTATAAAGTAAAACCACAGACCAATTTGCAAATGATCTTCAATGTTAAGCACTTG
CTCTAAGATTAAAATTCCTTTTCTTTTTAAGGTTAAGGGTGTGTACGTATGGCAGTGATGTCTATGTTGAGATTAACTTATGTATTGAGG
AAAATTTGAAGTTTATTTTTTCGATGAATAAGGCTGTCAAATGATTTAGTATAGATTAATGACATCTTTTTTAGAAATATTAAAGTGAGT
ATTCCTCATTATGTCATCATTTCTGATAATTAGAGTGCTAATTTGAATGTTAGATAATGTTTCCACATCTATACCTATTTCTTTCTAGGG
CACTTCTGACCCTGGGGCTTGGGGATGGCCTTTAGGCCACAGTAGTGTCTGTGTTAAGTTCACTAAATGTGTATTTAATGAGAAACATTC
CTATGTAAAAATGTGTGTATGTGAACGTATGCATACATTTTTATTGTGCACCTGTACATTGTGAAGAAGTAGTTTGGAAATTTGTAAAGC
ACAAACCATAAAAGAGTGTGGAGTTATTAAATGATGTAGCACAAATGTAATGTTTAGCTTATAAAAGGTCCTTTCTATTTTCTATGGCAA
AGACTTTGACACTTGAAAAATAAAACCAATATTTGATTTATTTTTGTAAGTATTTAGGATATTATTTTAAATAAATGATTGTCCATTATC

>30335_30335_3_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000371212_HOOK1_chr1_60299077_ENST00000371208_length(amino acids)=886AA_BP=0
MSGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWAACCVVTKNLREICWDKAGHFFDLPDFLSWK
ATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFVADNYSKIGNQVLPPGASLGNGLTPEAARDLGLLPGIAVAASLIDAHAGGLGV
IGADVRGHGLICEGQPVTSRLAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLFLGQQISEALIPDLNQITECS
DPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCE
ELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDEL
TSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLH
VKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQH
ENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHE
ELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESEC

--------------------------------------------------------------
>30335_30335_4_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000371218_HOOK1_chr1_60299077_ENST00000371208_length(transcript)=6522nt_BP=1195nt
CCCAGAAAGAGGCTTCTCCAACCCGGCCCGGCCCTTCCTTCCCCTTTCCCGCAGTCGTTGCCTCCTCCTCCCCTGCCTCCTCCTCCCCTT
CCTCCTCCTGGCCGCTTAGTCTCACACCCGCCGGGCCGTTGTTCCCGAGACGTTGTTGAGTCCCCTGTGTCCTCTTCTGGGTGGAGGAAC
TGCAATGTCTGGTGGAGAACAGAAACCAGAGAGGTACTATGTGGGTGTGGACGTTGGAACAGGCAGTGTCCGTGCAGCTCTGGTGGACCA
GAGTGGGGTCCTGTTGGCTTTTGCAGACCAGCCAATTAAGAATTGGGAGCCCCAGTTCAACCACCATGAGCAGTCCTCCGAGGACATCTG
GGCTGCGTGCTGTGTTGTCACAAAGAAAGTTGTACAAGGGATTGATTTAAACCAAATTCGAGGACTTGGGTTTGATGCCACGTGTTCTCT
GGTTGTTTTGGATAAGCAGTTTCACCCATTACCAGTCAACCAGGAAGGGGATTCCCATCGAAACGTCATCATGTGGCTGGACCATCGAGC
AGTCAGTCAAGTTAACAGGATCAATGAGACCAAGCACAGTGTCCTCCAGTACGTCGGGGGGGTGATGTCTGTGGAAATGCAGGCCCCGAA
ACTTCTGTGGCTGAAAGAGAACTTGAGAGAGATTTGCTGGGATAAGGCGGGACATTTCTTTGATCTCCCGGACTTCTTATCGTGGAAGGC
AACAGGTGTCACAGCACGGTCTCTCTGCTCCCTGGTGTGTAAGTGGACATATTCAGCAGAGAAAGGCTGGGACGACAGTTTCTGGAAAAT
GATTGGTTTGGAAGACTTTGTTGCAGATAATTACAGCAAAATAGGAAACCAAGTGCTACCTCCTGGAGCTTCTCTTGGAAATGGGCTCAC
ACCAGAGGCAGCAAGAGACCTTGGCCTTCTCCCTGGGATTGCGGTCGCAGCTTCACTCATTGATGCCCATGCAGGAGGACTAGGAGTGAT
TGGGGCAGATGTGAGAGGGCACGGCCTCATCTGTGAGGGGCAGCCAGTGACGTCACGGCTGGCTGTCATCTGTGGAACGTCTTCTTGTCA
CATGGGGATCAGCAAAGACCCGATTTTTGTACCAGGCGTCTGGGGGCCTTATTTCTCAGCCATGGTACCTGGGTTCTGGCTGAATGAAGG
TGGTCAGAGCGTTACTGGAAAATTGTTTTTGGGGCAGCAGATTTCAGAAGCACTTATCCCTGATTTAAACCAAATAACCGAATGTTCAGA
TCCAGTGGAGCTTGGGAGGTTGCTCCAGCTTATTTTAGGTTGTGCGATCAACTGTGAAAAGAAGCAAGAACATATTCAAAATATAATGAC
ACTGGAAGAGTCTGTTCAACATGTGGTCATGACTGCTATTCAAGAGTTGATGAGTAAAGAAATATTGAGCTCTCCTCCAAATGATGCTGT
TGGAGAATTGGAGCAACAGCTTAAAAGAGCCTTGGAAGAACTTCAGGAAGCACTAGCAGAAAAAGAAGAGCTGAGGCAAAGATGTGAAGA
ATTGGATATGCAGGTGACTACACTTCAAGATGAAAAGAATTCACTGGTTTCTGAAAATGAGATGATGAATGAAAAACTTGACCAGTTGGA
TGGCTCTTTTGATGATCCAAACACAGTGGTTGCAAAAAAGTATTTTCATGCACAATTACAACTAGAACAATTACAGGAAGAAAACTTCAG
GCTTGAAGCTGCAAAAGATGATTACCGTGTTCACTGTGAAGAACTTGAAAAGCAGCTAATCGAATTCCAGCATAGGAATGATGAATTGAC
TAGTCTTGCAGAAGAAACAAGAGCCCTGAAAGATGAAATAGATGTTCTTAGGGCTACCTCTGATAAAGCAAATAAACTGGAGTCAACAGT
TGAGATATATCGTCAGAAGCTACAAGATCTGAATGACCTTCGCAAGCAGGTGAAAACTTTACAGGAAACCAACATGATGTATATGCATAA
TACAGTCAGCTTAGAAGAAGAATTAAAAAAAGCAAATGCAGCACGTACACAATTAGAAACATACAAAAGGCAGGTTCAAGATCTTCATGT
TAAACTTTCCTCCGAATCCAAGAGGGCAGACACACTAGCGTTTGAAATGAAGCGGCTTGAAGAAAAACATGAAGCTTTACTTAAGGAAAA
AGAGAGACTAATTGAGCAGCGTGATACTTTGAAAGAAACAAATGAAGAGCTTCGATGTTCACAAGTACAACAGGACCACCTAAACCAAAC
AGATGCATCTGCTACAAAAAGTTATGAGAATCTTGCTGCTGAGATTATGCCAGTGGAATATAGGGAGGTGTTTATTCGACTGCAACATGA
AAATAAGATGCTTCGCTTACAGCAAGAAGGCTCTGAGAATGAACGTATTGAGGAACTTCAGGAGCAGCTAGAACAGAAACACCGTAAAAT
GAATGAACTGGAAACTGAGCAGAGGCTGAGCAAAGAGCGTATTAGAGAATTGCAGCAGCAGATTGAGGACCTCCAGAAATCTTTACAGGA
ACAAGGTTCCAAGTCTGAAGGCGAAAGTTCCAGCAAATTAAAGCAGAAGTTGGAAGCTCATATGGAAAAACTCACAGAGGTCCATGAAGA
ATTACAGAAGAAACAAGAACTCATTGAAGATCTTCAGCCAGATATAAATCAAAATGTACAAAAGATCAATGAACTTGAAGCTGCTCTTCA
GAAGAAAGATGAAGATATGAAAGCAATGGAGGAAAGATATAAAATGTACTTGGAGAAAGCCAGAAATGTAATAAAAACTTTGGATCCCAA
GTTAAATCCAGCATCAGCTGAAATAATGCTACTAAGAAAGCAGTTGGCAGAGAAAGAGAGAAGAATTGAGATTCTGGAGAGTGAATGCAA
AGTAGCAAAATTCCGTGATTATGAAGAAAAACTCATTGTTTCTGCGTGGTATAATAAGAGTCTAGCATTCCAGAAACTGGGGATGGAATC
TAGACTTGTGAGCGGCGGTGGTGCCTGCAGTGACACTGGTGCGTGCACTCCTGCGCGGTCTTTCTTAGCGCAGCAACGGCACATCACCAA
CACCAGAAGAAATCTCTCTGTTAAAGTCCCTGCTACAACATCTGATTAAACTGCAAAAAAAACAAAACAAAACAAAAAAACCACATAAAA
TAGAAGTGTCCTTAAAATATTTTGTACCTTTCAACTAACTACCAGATTGAAAAAGAGTTTATGATGCGGGATATCAGGTATTTTAAAATC
AACATGCATCAAATTAATTTTGCCAGTTGACTTTAAAAACAAATTATAGAATTAGCCATCTCTCTGAGGGAGCACATTTGAATAATTGGA
GATGCAGTTATACACACATTTCAAACAAACATTTGTCTTTTGAGAGTATTATAATTTCAAATTGGCCTTGTATATTTTAGTTAAATGTTT
TCAGTTGTATTAGTAACTTAATTAATTTTCAATAGCTATTCAGTAATACTTAATCTTAGAACATTAATTGGATTTGTTTAATCTTTTTTT
GTTTTTTGTTGATTTATATGAAAACAGTCTTGAGGCAGGGACATGGAGAACTATGCAAGGGTGATTTCTTTGACTTAATATATACAAGGC
TTTACTTCTGTCCCCTAATTCTTCCATTGAATGTGTACCTCTACCTTGTCATGTCATGGAAGATACAACATTTGGAAGATCTGACAATTG
GAATGACTTTGGAATAATAAAATTGACTAATTGGAAATTTTGCATATTCTGAAAATCTAATCTCATAGTTCTAATTTGTACCTATGGCAA
ATAAGGGCTTCTGGACATCATGTTTAAAATGTTAAGCATAAGAAATAAACTGACATTTGTAATAGGTGACTTTCTGATGGAAAGCAAGCT
ATATATATATATATATATATATATATATATATATATATACTTTTTGTGAAATGTCTATATACTTTTTAAGGTAATTAATGAAGATTTCAG
TTATTGCTTTTAAGCATAAAGTTGTATTTAGCTTCTGCTGAAAAATTGTATCATATAATAATTTTGCTTCATTGAAAAGGGATGTTGCAG
TGATGAAACAAGGTGGGATCAGTTTGATTTTGTTTACTTATTAAGGAGTTTATCTTGGGCTCAGTTTGTGGTATTCAGTTCGTTTCTGCC
CAAAGCTCTTATTTTCAGAGGTGTTACTTTTGAACTTTTGGGGTCATTTTTAAAAGTTAGCACTTTTGAATTTTAGTTGTGTTAAATATG
TGCTGTCGTATATCATAGCCATGAGCCATATATGACAATTTAAATTTAATTAATTATAAACTCAGTCTCTTGGTTGCACCAGCCACATTT
CAGATGCTCAATAGCCACATGTGGCTAGTGGGTACCATATTGGACAGGGCAGCTATAGAATATTTCCATCATTGCAGAAAGTTCTATTGG
ATAGTACCATAATCTTTTTATAGTAACTTGGAAATACTATTTGATATTAGATGTTAGACCACAAAAAGAAGAAAAATGTTAGGACTATTT
CAGATATAAAAAGGAACTGAATTGTGACATAATTAGCATCTTACATTCCATACAGTTGAATACCTTATGCTGTGACAACCATAGTTAATC
ATTTCAGTGCTGTTCAACATACATACCTATCAGCAGTGTGTTTAGACCAGGGGTCTGCAAACTTTCTGTGAATGGACAAAGAGTAAATAC
TTTAGTAAATGTCTTAGGCTTTGTGGCCTACATGATCTTTGTTGCAAGTACTCAACTCTGCCATTATAGAGTTAAAGCAGCCATACACAA
TATATAAACAAAATGGGCATAGTTGTATTTCAGTAAAACTTTATTTACAAAGACAGGCGGTAGGCCAGATTTGGCTTGCATGCTGTAGAG
CTGTGGTCTAAATTTTATTCATAGACTTTCTTTGCAAATACAGTGTGAGTATTGTTCCATTTACAGTATTATTATTTTTTAGATACCTGG
TTTTTAGATTCTTGCCTGGTAACTTTTTACTGAAAATACAAGAATTTCGTACTGCATTTGCATCTCCGAGATTAGGGAGCACCTGTCAGG
ATATGTTGTTCTATCAGGGTTACTTCTGTTGACTACCTCTTAGATTTTGATACAGTTATATTGTTGAGTTTCATTTTCATATATTCTTGT
AGTGTCTGCTTGCCTGTGACTTCTGGTAAAATAAAATAAGCCTTTGAAAATATTTTAGCATGGTATTTAACATTTTCTAAATATTATGGC
ATTTTGACATATTTTAGTCAGCGAAGACATCTGCCCCTTTGGTGTTTCTACTTGCTTATGATTGAGATTTTACAAGCCCTTCAAACTCCG
TTTTAAAGGAATTTATTGTAAAACATTAACTTTAATAAATTAGTGTTTTCACAGATCAGATCATTATACTTGGAACTTCTAAATCATGCA
ATTTCTGAATAAGGACATAAGGCTAGATTCATTTTTCTTAATAGAGAAAAAGGAAATTTCTGATTTATCACTTTTCTAGTTGATAAGTAG
GATTCAAAACGTTTGATATGTAAGTATTTATATAAGACTAATGTAATTTAAAGTTCTGTATTATTGTGATTAATCATACAGAAATTCAGG
AACTGATCAGAAGTGAGATTCTTTTCCACATCTGGTTAATGTAGTGAGTTGACACCCTGTGGGTGGTAAAGCATTATAAACATTTCATCT
TGAACCATGATTTATACACATCTGTGTTATAAGGGAGGCTTGAGTACATATACCAATGAAGAGATATTCAGCATTTGTCTATTTGATAAG
GAATTAAATGTCCTAGTGATTATAAAGTAAAACCACAGACCAATTTGCAAATGATCTTCAATGTTAAGCACTTGCTCTAAGATTAAAATT
CCTTTTCTTTTTAAGGTTAAGGGTGTGTACGTATGGCAGTGATGTCTATGTTGAGATTAACTTATGTATTGAGGAAAATTTGAAGTTTAT
TTTTTCGATGAATAAGGCTGTCAAATGATTTAGTATAGATTAATGACATCTTTTTTAGAAATATTAAAGTGAGTATTCCTCATTATGTCA
TCATTTCTGATAATTAGAGTGCTAATTTGAATGTTAGATAATGTTTCCACATCTATACCTATTTCTTTCTAGGGCACTTCTGACCCTGGG
GCTTGGGGATGGCCTTTAGGCCACAGTAGTGTCTGTGTTAAGTTCACTAAATGTGTATTTAATGAGAAACATTCCTATGTAAAAATGTGT
GTATGTGAACGTATGCATACATTTTTATTGTGCACCTGTACATTGTGAAGAAGTAGTTTGGAAATTTGTAAAGCACAAACCATAAAAGAG
TGTGGAGTTATTAAATGATGTAGCACAAATGTAATGTTTAGCTTATAAAAGGTCCTTTCTATTTTCTATGGCAAAGACTTTGACACTTGA
AAAATAAAACCAATATTTGATTTATTTTTGTAAGTATTTAGGATATTATTTTAAATAAATGATTGTCCATTATCAATATAATAGTTGTGA

>30335_30335_4_FGGY-HOOK1_FGGY_chr1_60073582_ENST00000371218_HOOK1_chr1_60299077_ENST00000371208_length(amino acids)=988AA_BP=1
MLSPLCPLLGGGTAMSGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWAACCVVTKKVVQGIDLN
QIRGLGFDATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAVSQVNRINETKHSVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAG
HFFDLPDFLSWKATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFVADNYSKIGNQVLPPGASLGNGLTPEAARDLGLLPGIAVAA
SLIDAHAGGLGVIGADVRGHGLICEGQPVTSRLAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLFLGQQISEA
LIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA
LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEK
QLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQ
LETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMP
VEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL
EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAE

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Fusion Gene PPI Analysis for FGGY-HOOK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGGY-HOOK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGGY-HOOK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource