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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FGR-SQSTM1 (FusionGDB2 ID:30343) |
Fusion Gene Summary for FGR-SQSTM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGR-SQSTM1 | Fusion gene ID: 30343 | Hgene | Tgene | Gene symbol | FGR | SQSTM1 | Gene ID | 2268 | 8878 |
| Gene name | FGR proto-oncogene, Src family tyrosine kinase | sequestosome 1 | |
| Synonyms | SRC2|c-fgr|c-src2|p55-Fgr|p55c-fgr|p58-Fgr|p58c-fgr | A170|DMRV|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62B | |
| Cytomap | 1p35.3 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologc-fgr protooncogenec-src-2 proto-oncogenefeline Gardner-Rasheed sarcoma viral oncogene homologp55-c-fgr proteinproto-oncogene c-Fgrproto-oncogene tyrosine-prote | sequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domain | |
| Modification date | 20200329 | 20200327 | |
| UniProtAcc | P09769 | Q13501 | |
| Ensembl transtripts involved in fusion gene | ENST00000374004, ENST00000374005, ENST00000399173, ENST00000468038, ENST00000545953, | ENST00000376929, ENST00000360718, ENST00000389805, ENST00000402874, ENST00000506690, ENST00000510187, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 33 X 21 X 17=11781 |
| # samples | 2 | 38 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(38/11781*10)=-4.95431877505661 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FGR [Title/Abstract] AND SQSTM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FGR(27942264)-SQSTM1(179252166), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FGR | GO:0018108 | peptidyl-tyrosine phosphorylation | 7519620|8327512 |
| Hgene | FGR | GO:0046777 | protein autophosphorylation | 2181286|8327512 |
| Tgene | SQSTM1 | GO:0006914 | autophagy | 20452972 |
| Tgene | SQSTM1 | GO:0007032 | endosome organization | 27368102 |
| Tgene | SQSTM1 | GO:0031397 | negative regulation of protein ubiquitination | 20452972 |
| Tgene | SQSTM1 | GO:0061635 | regulation of protein complex stability | 25127057 |
| Tgene | SQSTM1 | GO:1905719 | protein localization to perinuclear region of cytoplasm | 27368102 |
| Fusion gene breakpoints across FGR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SQSTM1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BG314620 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
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Fusion Gene ORF analysis for FGR-SQSTM1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000374004 | ENST00000376929 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-3CDS | ENST00000374005 | ENST00000376929 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-3CDS | ENST00000399173 | ENST00000376929 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-3CDS | ENST00000468038 | ENST00000376929 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-3CDS | ENST00000545953 | ENST00000376929 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374004 | ENST00000360718 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374004 | ENST00000389805 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374004 | ENST00000402874 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374004 | ENST00000506690 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374004 | ENST00000510187 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374005 | ENST00000360718 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374005 | ENST00000389805 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374005 | ENST00000402874 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374005 | ENST00000506690 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000374005 | ENST00000510187 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000399173 | ENST00000360718 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000399173 | ENST00000389805 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000399173 | ENST00000402874 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000399173 | ENST00000506690 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000399173 | ENST00000510187 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000468038 | ENST00000360718 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000468038 | ENST00000389805 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000468038 | ENST00000402874 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000468038 | ENST00000506690 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000468038 | ENST00000510187 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000545953 | ENST00000360718 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000545953 | ENST00000389805 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000545953 | ENST00000402874 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000545953 | ENST00000506690 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| intron-intron | ENST00000545953 | ENST00000510187 | FGR | chr1 | 27942264 | - | SQSTM1 | chr5 | 179252166 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FGR-SQSTM1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FGR-SQSTM1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27942264/:179252166) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGR | SQSTM1 |
| FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. | FUNCTION: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215). {ECO:0000250|UniProtKB:O08623, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:33393215}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FGR-SQSTM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for FGR-SQSTM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FGR-SQSTM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FGR-SQSTM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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