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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FHOD3-GALNT1 (FusionGDB2 ID:30392)

Fusion Gene Summary for FHOD3-GALNT1

check button Fusion gene summary
Fusion gene informationFusion gene name: FHOD3-GALNT1
Fusion gene ID: 30392
HgeneTgene
Gene symbol

FHOD3

GALNT1

Gene ID

91010

2589

Gene nameformin like 3polypeptide N-acetylgalactosaminyltransferase 1
SynonymsFHOD3|FRL2|WBP-3|WBP3GALNAC-T1
Cytomap

12q13.12

18q12.2

Type of geneprotein-codingprotein-coding
Descriptionformin-like protein 3WW domain binding protein 3formin homology 2 domain-containing protein 3polypeptide N-acetylgalactosaminyltransferase 1GalNAc transferase 1UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)polypeptide GalNAc transferase 1
Modification date2020032220200313
UniProtAcc

Q2V2M9

Q6P9A2

Ensembl transtripts involved in fusion geneENST00000257209, ENST00000359247, 
ENST00000445677, ENST00000590592, 
ENST00000587493, ENST00000591635, 
ENST00000592128, 		ENST00000537549, 
ENST00000269195, ENST00000586725, 
ENST00000591081, 
Fusion gene scores* DoF score8 X 6 X 8=3844 X 3 X 4=48
# samples 134
** MAII scorelog2(13/384*10)=-1.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FHOD3 [Title/Abstract] AND GALNT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFHOD3(33877963)-GALNT1(33243592), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGALNT1

GO:0006493

protein O-linked glycosylation

22186971

TgeneGALNT1

GO:0018242

protein O-linked glycosylation via serine

9295285

TgeneGALNT1

GO:0018243

protein O-linked glycosylation via threonine

9295285


check buttonFusion gene breakpoints across FHOD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GALNT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-A5MR-01AFHOD3chr18

33877963

-GALNT1chr18

33243592

+
ChimerDB4LUSCTCGA-63-A5MRFHOD3chr18

33877963

+GALNT1chr18

33243592

+


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Fusion Gene ORF analysis for FHOD3-GALNT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000257209ENST00000537549FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-5UTRENST00000359247ENST00000537549FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-5UTRENST00000445677ENST00000537549FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-5UTRENST00000590592ENST00000537549FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000257209ENST00000269195FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000257209ENST00000586725FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000257209ENST00000591081FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000359247ENST00000269195FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000359247ENST00000586725FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000359247ENST00000591081FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000445677ENST00000269195FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000445677ENST00000586725FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000445677ENST00000591081FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000590592ENST00000269195FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000590592ENST00000586725FHOD3chr18

33877963

+GALNT1chr18

33243592

+
5CDS-intronENST00000590592ENST00000591081FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-5UTRENST00000587493ENST00000537549FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-5UTRENST00000591635ENST00000537549FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-5UTRENST00000592128ENST00000537549FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000587493ENST00000269195FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000587493ENST00000586725FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000587493ENST00000591081FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000591635ENST00000269195FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000591635ENST00000586725FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000591635ENST00000591081FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000592128ENST00000269195FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000592128ENST00000586725FHOD3chr18

33877963

+GALNT1chr18

33243592

+
intron-intronENST00000592128ENST00000591081FHOD3chr18

33877963

+GALNT1chr18

33243592

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FHOD3-GALNT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FHOD3chr1833877963+GALNT1chr1833243591+0.0005416230.9994584
FHOD3chr1833877963+GALNT1chr1833243591+0.0005416230.9994584

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FHOD3-GALNT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33877963/:33243592)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FHOD3

Q2V2M9

GALNT1

Q6P9A2

FUNCTION: Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}.FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000269|PubMed:22186971}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FHOD3-GALNT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FHOD3-GALNT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FHOD3-GALNT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FHOD3-GALNT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource