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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FKBP14-EIF4A1 (FusionGDB2 ID:30453) |
Fusion Gene Summary for FKBP14-EIF4A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FKBP14-EIF4A1 | Fusion gene ID: 30453 | Hgene | Tgene | Gene symbol | FKBP14 | EIF4A1 | Gene ID | 55033 | 1973 |
| Gene name | FKBP prolyl isomerase 14 | eukaryotic translation initiation factor 4A1 | |
| Synonyms | EDSKMH|EDSKSCL2|FKBP22|IPBP12 | DDX2A|EIF-4A|EIF4A|eIF-4A-I|eIF4A-I | |
| Cytomap | 7p14.3 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peptidyl-prolyl cis-trans isomerase FKBP1422 kDa FK506-binding protein22 kDa FKBPFK506 binding protein 14, 22 kDaFK506-binding protein 14FKBP-22PPIase FKBP14rotamase | eukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4A | |
| Modification date | 20200313 | 20200322 | |
| UniProtAcc | Q9NWM8 | P60842 | |
| Ensembl transtripts involved in fusion gene | ENST00000222803, | ENST00000581808, ENST00000380512, ENST00000293831, ENST00000577269, ENST00000582746, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 8 X 5 X 5=200 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FKBP14 [Title/Abstract] AND EIF4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FKBP14(30062280)-EIF4A1(7478436), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FKBP14-EIF4A1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. FKBP14-EIF4A1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FKBP14 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across EIF4A1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 13N | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + |
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Fusion Gene ORF analysis for FKBP14-EIF4A1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000222803 | ENST00000581808 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + |
| Frame-shift | ENST00000222803 | ENST00000380512 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + |
| In-frame | ENST00000222803 | ENST00000293831 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + |
| In-frame | ENST00000222803 | ENST00000577269 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + |
| In-frame | ENST00000222803 | ENST00000582746 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000222803 | FKBP14 | chr7 | 30062280 | - | ENST00000293831 | EIF4A1 | chr17 | 7478436 | + | 2060 | 525 | 176 | 1540 | 454 |
| ENST00000222803 | FKBP14 | chr7 | 30062280 | - | ENST00000577269 | EIF4A1 | chr17 | 7478436 | + | 1634 | 525 | 176 | 1363 | 395 |
| ENST00000222803 | FKBP14 | chr7 | 30062280 | - | ENST00000582746 | EIF4A1 | chr17 | 7478436 | + | 1965 | 525 | 176 | 1345 | 389 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000222803 | ENST00000293831 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + | 0.000775806 | 0.9992242 |
| ENST00000222803 | ENST00000577269 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + | 0.001218556 | 0.9987815 |
| ENST00000222803 | ENST00000582746 | FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + | 0.001150003 | 0.99885 |
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Fusion Genomic Features for FKBP14-EIF4A1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + | 0.30420804 | 0.6957919 |
| FKBP14 | chr7 | 30062280 | - | EIF4A1 | chr17 | 7478436 | + | 0.30420804 | 0.6957919 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FKBP14-EIF4A1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:30062280/chr17:7478436) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FKBP14 | EIF4A1 |
| FUNCTION: PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. {ECO:0000269|PubMed:24821723}. | FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000293831 | 2 | 11 | 245_406 | 68 | 407.0 | Domain | Helicase C-terminal | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000577269 | 2 | 11 | 245_406 | 68 | 348.0 | Domain | Helicase C-terminal | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000293831 | 2 | 11 | 182_185 | 68 | 407.0 | Motif | Note=DEAD box | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000577269 | 2 | 11 | 182_185 | 68 | 348.0 | Motif | Note=DEAD box | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000293831 | 2 | 11 | 76_83 | 68 | 407.0 | Nucleotide binding | ATP | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000577269 | 2 | 11 | 76_83 | 68 | 348.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FKBP14 | chr7:30062280 | chr17:7478436 | ENST00000222803 | - | 2 | 4 | 148_159 | 116 | 212.0 | Calcium binding | 1 |
| Hgene | FKBP14 | chr7:30062280 | chr17:7478436 | ENST00000222803 | - | 2 | 4 | 192_203 | 116 | 212.0 | Calcium binding | 2 |
| Hgene | FKBP14 | chr7:30062280 | chr17:7478436 | ENST00000222803 | - | 2 | 4 | 135_170 | 116 | 212.0 | Domain | EF-hand 1 |
| Hgene | FKBP14 | chr7:30062280 | chr17:7478436 | ENST00000222803 | - | 2 | 4 | 179_211 | 116 | 212.0 | Domain | EF-hand 2 |
| Hgene | FKBP14 | chr7:30062280 | chr17:7478436 | ENST00000222803 | - | 2 | 4 | 45_135 | 116 | 212.0 | Domain | PPIase FKBP-type |
| Hgene | FKBP14 | chr7:30062280 | chr17:7478436 | ENST00000222803 | - | 2 | 4 | 208_211 | 116 | 212.0 | Motif | Prevents secretion from ER |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000293831 | 2 | 11 | 63_234 | 68 | 407.0 | Domain | Helicase ATP-binding | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000577269 | 2 | 11 | 63_234 | 68 | 348.0 | Domain | Helicase ATP-binding | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000293831 | 2 | 11 | 32_60 | 68 | 407.0 | Motif | Note=Q motif | |
| Tgene | EIF4A1 | chr7:30062280 | chr17:7478436 | ENST00000577269 | 2 | 11 | 32_60 | 68 | 348.0 | Motif | Note=Q motif |
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Fusion Gene Sequence for FKBP14-EIF4A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >30453_30453_1_FKBP14-EIF4A1_FKBP14_chr7_30062280_ENST00000222803_EIF4A1_chr17_7478436_ENST00000293831_length(transcript)=2060nt_BP=525nt AGGTTCGTGACCCTTGAGAAAAGAGTTGGTGGTAAATGTGCCACGTCTTCTAAGAAGGGGGAGTCCTGAACTTGTCTGAAGCCCTTGTCC GTAAGCCTTGAACTACGTTCTTAAATCTATGAAGTCGAGGGACCTTTCGCTGCTTTTGTAGGGACTTCTTTCCTTGCTTCAGCAACATGA GGCTTTTCTTGTGGAACGCGGTCTTGACTCTGTTCGTCACTTCTTTGATTGGGGCTTTGATCCCTGAACCAGAAGTGAAAATTGAAGTTC TCCAGAAGCCATTCATCTGCCATCGCAAGACCAAAGGAGGGGATTTGATGTTGGTCCACTATGAAGGCTACTTAGAAAAGGACGGCTCCT TATTTCACTCCACTCACAAACATAACAATGGTCAGCCCATTTGGTTTACCCTGGGCATCCTGGAGGCTCTCAAAGGTTGGGACCAGGGCT TGAAAGGAATGTGTGTAGGAGAGAAGAGAAAGCTCATCATTCCTCCTGCTCTGGGCTATGGAAAAGAAGGAAAAGGTTATGATGTGATTG CTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCT TGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCT GTATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTG ATATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGG ACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGA CCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGG AACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGA AGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGA TTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGCCAGAGGCATTGATGTGCAGCAGGTTTCTTTAG TCATCAACTATGACCTTCCCACCAACAGGGAAAACTATATCCACAGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGTGTGGCTATTA ACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTCAATGTTGCTG ACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGGAGGGAAGGGA GCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATTTTAGACACCC TTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAACCTAGTAACC TCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTTGCTGGACCAA ATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGAAAATGGTAGC >30453_30453_1_FKBP14-EIF4A1_FKBP14_chr7_30062280_ENST00000222803_EIF4A1_chr17_7478436_ENST00000293831_length(amino acids)=454AA_BP=116 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQ GLKGMCVGEKRKLIIPPALGYGKEGKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCH ACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLE VTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERD VIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNV -------------------------------------------------------------- >30453_30453_2_FKBP14-EIF4A1_FKBP14_chr7_30062280_ENST00000222803_EIF4A1_chr17_7478436_ENST00000577269_length(transcript)=1634nt_BP=525nt AGGTTCGTGACCCTTGAGAAAAGAGTTGGTGGTAAATGTGCCACGTCTTCTAAGAAGGGGGAGTCCTGAACTTGTCTGAAGCCCTTGTCC GTAAGCCTTGAACTACGTTCTTAAATCTATGAAGTCGAGGGACCTTTCGCTGCTTTTGTAGGGACTTCTTTCCTTGCTTCAGCAACATGA GGCTTTTCTTGTGGAACGCGGTCTTGACTCTGTTCGTCACTTCTTTGATTGGGGCTTTGATCCCTGAACCAGAAGTGAAAATTGAAGTTC TCCAGAAGCCATTCATCTGCCATCGCAAGACCAAAGGAGGGGATTTGATGTTGGTCCACTATGAAGGCTACTTAGAAAAGGACGGCTCCT TATTTCACTCCACTCACAAACATAACAATGGTCAGCCCATTTGGTTTACCCTGGGCATCCTGGAGGCTCTCAAAGGTTGGGACCAGGGCT TGAAAGGAATGTGTGTAGGAGAGAAGAGAAAGCTCATCATTCCTCCTGCTCTGGGCTATGGAAAAGAAGGAAAAGGTTATGATGTGATTG CTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCT TGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCT GTATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTG ATATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGG ACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGA CCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGG AACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGA AGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGA TTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGGGAAAACTATATCCACAGAATCGGTCGAGGTGGA CGGTTTGGCCGTAAAGGTGTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCC ATTGAGGAAATGCCCCTCAATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGA GGAGCAGCAGGAGGGGGGAGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAA >30453_30453_2_FKBP14-EIF4A1_FKBP14_chr7_30062280_ENST00000222803_EIF4A1_chr17_7478436_ENST00000577269_length(amino acids)=395AA_BP=116 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQ GLKGMCVGEKRKLIIPPALGYGKEGKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCH ACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLE VTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERD -------------------------------------------------------------- >30453_30453_3_FKBP14-EIF4A1_FKBP14_chr7_30062280_ENST00000222803_EIF4A1_chr17_7478436_ENST00000582746_length(transcript)=1965nt_BP=525nt AGGTTCGTGACCCTTGAGAAAAGAGTTGGTGGTAAATGTGCCACGTCTTCTAAGAAGGGGGAGTCCTGAACTTGTCTGAAGCCCTTGTCC GTAAGCCTTGAACTACGTTCTTAAATCTATGAAGTCGAGGGACCTTTCGCTGCTTTTGTAGGGACTTCTTTCCTTGCTTCAGCAACATGA GGCTTTTCTTGTGGAACGCGGTCTTGACTCTGTTCGTCACTTCTTTGATTGGGGCTTTGATCCCTGAACCAGAAGTGAAAATTGAAGTTC TCCAGAAGCCATTCATCTGCCATCGCAAGACCAAAGGAGGGGATTTGATGTTGGTCCACTATGAAGGCTACTTAGAAAAGGACGGCTCCT TATTTCACTCCACTCACAAACATAACAATGGTCAGCCCATTTGGTTTACCCTGGGCATCCTGGAGGCTCTCAAAGGTTGGGACCAGGGCT TGAAAGGAATGTGTGTAGGAGAGAAGAGAAAGCTCATCATTCCTCCTGCTCTGGGCTATGGAAAAGAAGGAAAAGGTTATGATGTGATTG CTCAAGCCCAATCTGGGACTGGGAAAACGGCCACATTTGCCATATCGATTCTGCAGCAGATTGAATTAGATCTAAAAGCCACCCAGGCCT TGGTCCTAGCACCCACTCGAGAATTGGCTCAGCAGATACAGAAGGTGGTCATGGCACTAGGAGACTACATGGGCGCCTCCTGTCACGCCT GTATCGGGGGCACCAACGTGCGTGCTGAGGTGCAGAAACTGCAGATGGAAGCTCCCCACATCATCGTGGGTACCCCTGGCCGTGTGTTTG ATATGCTTAACCGGAGATACCTGTCCCCCAAATACATCAAGATGTTTGTACTGGATGAAGCTGACGAAATGTTAAGCCGTGGATTCAAGG ACCAGATCTATGACATATTCCAAAAGCTCAACAGCAACACCCAGGTAGTTTTGCTGTCAGCCACAATGCCTTCTGATGTGCTTGAGGTGA CCAAGAAGTTCATGAGGGACCCCATTCGGATTCTTGTCAAGAAGGAAGAGTTGACCCTGGAGGGTATCCGCCAGTTCTACATCAACGTGG AACGAGAGGAGTGGAAGCTGGACACACTATGTGACTTGTATGAAACCCTGACCATCACCCAGGCAGTCATCTTCATCAACACCCGGAGGA AGGTGGACTGGCTCACCGAGAAGATGCATGCTCGAGATTTCACTGTATCCGCCATGCATGGAGATATGGACCAAAAGGAACGAGACGTGA TTATGAGGGAGTTTCGTTCTGGCTCTAGCAGAGTTTTGATTACCACTGACCTGCTGAATCGGTCGAGGTGGACGGTTTGGCCGTAAAGGT GTGGCTATTAACATGGTGACAGAAGAAGACAAGAGGACTCTTCGAGACATTGAGACCTTCTACAACACCTCCATTGAGGAAATGCCCCTC AATGTTGCTGACCTCATCTGAGGGGCTGTCCTGCCACCCAGCCCCAGCCAGGGCTCAATCTCTGGGGGCTGAGGAGCAGCAGGAGGGGGG AGGGAAGGGAGCCAAGGGATGGACATCTTGTCATTTTTTTTCTTTGAATAAATGTCACTTTTTGAGGCAAAAGAAGGAACCGTGAACATT TTAGACACCCTTTTCTTTGGGGTAGGCTCTTGCCCCAGGCGCCGGCTCTTCTCCCAAAAAAAAAAAAAAAACACTAATCCATTTCCCTAA CCTAGTAACCTCCAGATCCCAGAGGCTCTCCTCACCTCAGCTGAGCTCCTTTGAAAGTGATTCAAGGGACTATGTCACTCAGCCTCATTT GCTGGACCAAATCTGGAGGGAGAACCCCTAAAACCCCTAAGTGAGGTTGCCCAGGGGGTTGTCCCCAGGTGGGGGGAAGCAGGGGAGAGA >30453_30453_3_FKBP14-EIF4A1_FKBP14_chr7_30062280_ENST00000222803_EIF4A1_chr17_7478436_ENST00000582746_length(amino acids)=389AA_BP=116 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQ GLKGMCVGEKRKLIIPPALGYGKEGKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCH ACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLE VTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FKBP14-EIF4A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FKBP14-EIF4A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FKBP14-EIF4A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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