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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FKBP15-RET (FusionGDB2 ID:30459)

Fusion Gene Summary for FKBP15-RET

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP15-RET
Fusion gene ID: 30459
HgeneTgene
Gene symbol

FKBP15

RET

Gene ID

23307

5979

Gene nameFKBP prolyl isomerase 15ret proto-oncogene
SynonymsFKBP133|KIAA0674|PPP1R76CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

9q32

10q11.21

Type of geneprotein-codingprotein-coding
DescriptionFK506-binding protein 15133 kDa FK506-binding protein133 kDa FKBPFK506 binding protein 15, 133kDaFK506-binding protein 133kDaFKBP-133FKBP-15WAFLWASP and FKBP-like proteinprotein phosphatase 1, regulatory subunit 76proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc

Q5T1M5

RTL1

Ensembl transtripts involved in fusion geneENST00000238256, ENST00000493847, 
ENST00000340058, ENST00000355710, 
Fusion gene scores* DoF score4 X 7 X 4=11232 X 31 X 11=10912
# samples 748
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FKBP15 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFKBP15(115932802)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFKBP15

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across FKBP15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2971-03AFKBP15chr9

115936842

-RETchr10

43607584

+
ChimerDB4THCATCGA-ET-A3DQ-01AFKBP15chr9

115932802

-RETchr10

43612032

+
ChimerDB4THCATCGA-ET-A3DQFKBP15chr9

115932801

-RETchr10

43612031

+


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Fusion Gene ORF analysis for FKBP15-RET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000238256ENST00000340058FKBP15chr9

115932802

-RETchr10

43612032

+
In-frameENST00000238256ENST00000340058FKBP15chr9

115932801

-RETchr10

43612031

+
In-frameENST00000238256ENST00000355710FKBP15chr9

115932802

-RETchr10

43612032

+
In-frameENST00000238256ENST00000355710FKBP15chr9

115932801

-RETchr10

43612031

+
intron-3CDSENST00000238256ENST00000340058FKBP15chr9

115936842

-RETchr10

43607584

+
intron-3CDSENST00000238256ENST00000355710FKBP15chr9

115936842

-RETchr10

43607584

+
intron-3CDSENST00000493847ENST00000340058FKBP15chr9

115936842

-RETchr10

43607584

+
intron-3CDSENST00000493847ENST00000340058FKBP15chr9

115932802

-RETchr10

43612032

+
intron-3CDSENST00000493847ENST00000340058FKBP15chr9

115932801

-RETchr10

43612031

+
intron-3CDSENST00000493847ENST00000355710FKBP15chr9

115936842

-RETchr10

43607584

+
intron-3CDSENST00000493847ENST00000355710FKBP15chr9

115932802

-RETchr10

43612032

+
intron-3CDSENST00000493847ENST00000355710FKBP15chr9

115932801

-RETchr10

43612031

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000238256FKBP15chr9115932802-ENST00000355710RETchr1043612032+6175288411840921324
ENST00000238256FKBP15chr9115932802-ENST00000340058RETchr1043612032+4717288411839661282
ENST00000238256FKBP15chr9115932801-ENST00000355710RETchr1043612031+6175288411840921324
ENST00000238256FKBP15chr9115932801-ENST00000340058RETchr1043612031+4717288411839661282

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000238256ENST00000355710FKBP15chr9115932802-RETchr1043612032+0.0010126830.99898726
ENST00000238256ENST00000340058FKBP15chr9115932802-RETchr1043612032+0.0040117140.9959883
ENST00000238256ENST00000355710FKBP15chr9115932801-RETchr1043612031+0.0010126830.99898726
ENST00000238256ENST00000340058FKBP15chr9115932801-RETchr1043612031+0.0040117140.9959883

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Fusion Genomic Features for FKBP15-RET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FKBP15chr9115932801-RETchr1043612031+0.0116624540.9883376
FKBP15chr9115932801-RETchr1043612031+0.0116624540.9883376
FKBP15chr9115932801-RETchr1043612031+0.0116624540.9883376
FKBP15chr9115932801-RETchr1043612031+0.0116624540.9883376

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FKBP15-RET


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:115932802/chr10:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP15

Q5T1M5

RET

RTL1

FUNCTION: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP15chr9:115932801chr10:43612031ENST00000238256-2528522_7899221220.0Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932801chr10:43612031ENST00000238256-2528818_8789221220.0Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528522_7899221220.0Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528818_8789221220.0Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932801chr10:43612031ENST00000238256-2528197_2909221220.0DomainPPIase FKBP-type
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528197_2909221220.0DomainPPIase FKBP-type
HgeneFKBP15chr9:115932801chr10:43612031ENST00000238256-252872_1699221220.0RegionImportant for function in growth cone organization
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-252872_1699221220.0RegionImportant for function in growth cone organization
TgeneRETchr9:115932801chr10:43612031ENST000003400581019724_10167121073.0DomainProtein kinase
TgeneRETchr9:115932801chr10:43612031ENST000003557101020724_10167121115.0DomainProtein kinase
TgeneRETchr9:115932802chr10:43612032ENST000003400581019724_10167121073.0DomainProtein kinase
TgeneRETchr9:115932802chr10:43612032ENST000003557101020724_10167121115.0DomainProtein kinase
TgeneRETchr9:115932801chr10:43612031ENST000003400581019730_7387121073.0Nucleotide bindingATP
TgeneRETchr9:115932801chr10:43612031ENST000003557101020730_7387121115.0Nucleotide bindingATP
TgeneRETchr9:115932802chr10:43612032ENST000003400581019730_7387121073.0Nucleotide bindingATP
TgeneRETchr9:115932802chr10:43612032ENST000003557101020730_7387121115.0Nucleotide bindingATP
TgeneRETchr9:115932801chr10:43612031ENST000003400581019805_8077121073.0RegionNote=Inhibitors binding
TgeneRETchr9:115932801chr10:43612031ENST000003557101020805_8077121115.0RegionNote=Inhibitors binding
TgeneRETchr9:115932802chr10:43612032ENST000003400581019805_8077121073.0RegionNote=Inhibitors binding
TgeneRETchr9:115932802chr10:43612032ENST000003557101020805_8077121115.0RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP15chr9:115932801chr10:43612031ENST00000238256-2528925_9519221220.0Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528925_9519221220.0Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932801chr10:43612031ENST00000238256-25281208_12169221220.0Compositional biasNote=Poly-Asp
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-25281208_12169221220.0Compositional biasNote=Poly-Asp
TgeneRETchr9:115932801chr10:43612031ENST000003400581019168_2727121073.0DomainCadherin
TgeneRETchr9:115932801chr10:43612031ENST000003557101020168_2727121115.0DomainCadherin
TgeneRETchr9:115932802chr10:43612032ENST000003400581019168_2727121073.0DomainCadherin
TgeneRETchr9:115932802chr10:43612032ENST000003557101020168_2727121115.0DomainCadherin
TgeneRETchr9:115932801chr10:43612031ENST00000340058101929_6357121073.0Topological domainExtracellular
TgeneRETchr9:115932801chr10:43612031ENST000003400581019658_11147121073.0Topological domainCytoplasmic
TgeneRETchr9:115932801chr10:43612031ENST00000355710102029_6357121115.0Topological domainExtracellular
TgeneRETchr9:115932801chr10:43612031ENST000003557101020658_11147121115.0Topological domainCytoplasmic
TgeneRETchr9:115932802chr10:43612032ENST00000340058101929_6357121073.0Topological domainExtracellular
TgeneRETchr9:115932802chr10:43612032ENST000003400581019658_11147121073.0Topological domainCytoplasmic
TgeneRETchr9:115932802chr10:43612032ENST00000355710102029_6357121115.0Topological domainExtracellular
TgeneRETchr9:115932802chr10:43612032ENST000003557101020658_11147121115.0Topological domainCytoplasmic
TgeneRETchr9:115932801chr10:43612031ENST000003400581019636_6577121073.0TransmembraneHelical
TgeneRETchr9:115932801chr10:43612031ENST000003557101020636_6577121115.0TransmembraneHelical
TgeneRETchr9:115932802chr10:43612032ENST000003400581019636_6577121073.0TransmembraneHelical
TgeneRETchr9:115932802chr10:43612032ENST000003557101020636_6577121115.0TransmembraneHelical


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Fusion Gene Sequence for FKBP15-RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30459_30459_1_FKBP15-RET_FKBP15_chr9_115932801_ENST00000238256_RET_chr10_43612031_ENST00000340058_length(transcript)=4717nt_BP=2884nt
AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC
TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT
GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA
GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA
TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT
TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC
CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA
GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA
AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA
GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC
CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT
TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC
TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT
TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC
ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC
TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT
AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA
TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC
AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA
TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG
CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA
GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA
GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA
GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA
TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA
AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA
GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA
ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT
ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG
AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA
GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT
GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT
CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC
AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA
CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT
CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG
CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG
GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC
GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA
ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC
CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA
CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA
GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT
GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAG
ATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCT
CTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAA
TAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGT
TGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGT
TGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAG
AGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGG
AGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTC
AGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAA

>30459_30459_1_FKBP15-RET_FKBP15_chr9_115932801_ENST00000238256_RET_chr10_43612031_ENST00000340058_length(amino acids)=1282AA_BP=922
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQY
VKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI
GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH
SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR
VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE
HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPR

--------------------------------------------------------------
>30459_30459_2_FKBP15-RET_FKBP15_chr9_115932801_ENST00000238256_RET_chr10_43612031_ENST00000355710_length(transcript)=6175nt_BP=2884nt
AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC
TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT
GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA
GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA
TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT
TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC
CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA
GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA
AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA
GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC
CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT
TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC
TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT
TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC
ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC
TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT
AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA
TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC
AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA
TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG
CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA
GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA
GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA
GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA
TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA
AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA
GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA
ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT
ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG
AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA
GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT
GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT
CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC
AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA
CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT
CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG
CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG
GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC
GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA
ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC
CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA
CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA
GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT
GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGG
AGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCT
TTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCT
GAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAG
TTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTC
TTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCAC
ATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAAT
TTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGG
GGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGA
ATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAG
AGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCC
TCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGA
GGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTT
AGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCA
ATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGC
CCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTT
GTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTC
TGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACT
TAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATG
CGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTT
GGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAG
TCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCT
CAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTG
TCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTAT
TACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTT

>30459_30459_2_FKBP15-RET_FKBP15_chr9_115932801_ENST00000238256_RET_chr10_43612031_ENST00000355710_length(amino acids)=1324AA_BP=922
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQY
VKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI
GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH
SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR
VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE
HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPR

--------------------------------------------------------------
>30459_30459_3_FKBP15-RET_FKBP15_chr9_115932802_ENST00000238256_RET_chr10_43612032_ENST00000340058_length(transcript)=4717nt_BP=2884nt
AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC
TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT
GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA
GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA
TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT
TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC
CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA
GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA
AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA
GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC
CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT
TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC
TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT
TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC
ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC
TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT
AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA
TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC
AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA
TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG
CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA
GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA
GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA
GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA
TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA
AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA
GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA
ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT
ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG
AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA
GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT
GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT
CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC
AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA
CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT
CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG
CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG
GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC
GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA
ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC
CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA
CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA
GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT
GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAG
ATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCT
CTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAA
TAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGT
TGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGT
TGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAG
AGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGG
AGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTC
AGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAA

>30459_30459_3_FKBP15-RET_FKBP15_chr9_115932802_ENST00000238256_RET_chr10_43612032_ENST00000340058_length(amino acids)=1282AA_BP=922
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQY
VKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI
GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH
SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR
VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE
HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPR

--------------------------------------------------------------
>30459_30459_4_FKBP15-RET_FKBP15_chr9_115932802_ENST00000238256_RET_chr10_43612032_ENST00000355710_length(transcript)=6175nt_BP=2884nt
AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC
TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT
GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA
GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA
TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT
TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC
CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA
GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA
AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA
GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC
CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT
TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC
TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT
TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC
ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC
TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT
AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA
TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC
AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA
TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG
CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA
GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA
GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA
GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA
TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA
AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA
GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA
ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT
ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG
AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA
GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT
GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT
CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC
AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA
CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT
CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG
CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG
GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC
GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA
ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC
CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA
CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA
GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT
GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGG
AGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCT
TTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCT
GAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAG
TTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTC
TTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCAC
ATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAAT
TTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGG
GGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGA
ATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAG
AGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCC
TCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGA
GGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTT
AGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCA
ATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGC
CCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTT
GTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTC
TGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACT
TAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATG
CGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTT
GGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAG
TCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCT
CAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTG
TCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTAT
TACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTT

>30459_30459_4_FKBP15-RET_FKBP15_chr9_115932802_ENST00000238256_RET_chr10_43612032_ENST00000355710_length(amino acids)=1324AA_BP=922
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQY
VKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI
GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH
SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR
VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE
HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPR

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Fusion Gene PPI Analysis for FKBP15-RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FKBP15-RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FKBP15-RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource