Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AHCYL1-DENND2D (FusionGDB2 ID:3049)

Fusion Gene Summary for AHCYL1-DENND2D

Fusion gene summary

Fusion gene information	Fusion gene name: AHCYL1-DENND2D
	Fusion gene ID: 3049
		Hgene	Tgene
	Gene symbol	AHCYL1	DENND2D
	Gene ID	10768	79961
	Gene name	adenosylhomocysteinase like 1	DENN domain containing 2D
	Synonyms	DCAL\|IRBIT\|PPP1R78\|PRO0233\|XPVKONA	-
	Cytomap	1p13.3	1p13.3-p13.2
	Type of gene	protein-coding	protein-coding
	Description	S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cell	DENN domain-containing protein 2DDENN/MADD domain containing 2DRP5-1180E21.2
	Modification date	20200313	20200313
	UniProtAcc	O43865	Q9H6A0
	Ensembl transtripts involved in fusion gene	ENST00000475081, ENST00000369799, ENST00000359172, ENST00000393614,	ENST00000357640, ENST00000369752, ENST00000473682,
Fusion gene scores	* DoF score	12 X 9 X 4=432	3 X 3 X 2=18
	# samples	14	3
	** MAII score	log2(14/432*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: AHCYL1 [Title/Abstract] AND DENND2D [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AHCYL1(110527794)-DENND2D(111737348), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AHCYL1	GO:0006378	mRNA polyadenylation	19224921
Hgene	AHCYL1	GO:0031440	regulation of mRNA 3'-end processing	19224921
Hgene	AHCYL1	GO:0038166	angiotensin-activated signaling pathway	20584908
Hgene	AHCYL1	GO:0051592	response to calcium ion	18829453

Fusion gene breakpoints across AHCYL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DENND2D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A5FK-01A	AHCYL1	chr1	110527794	-	DENND2D	chr1	111737348	-
ChimerDB4	BRCA	TCGA-E9-A5FK-01A	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-

Top

Fusion Gene ORF analysis for AHCYL1-DENND2D

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000475081	ENST00000357640	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
3UTR-3CDS	ENST00000475081	ENST00000369752	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
3UTR-intron	ENST00000475081	ENST00000473682	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
5CDS-intron	ENST00000369799	ENST00000473682	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
In-frame	ENST00000369799	ENST00000357640	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
In-frame	ENST00000369799	ENST00000369752	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
intron-3CDS	ENST00000359172	ENST00000357640	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
intron-3CDS	ENST00000359172	ENST00000369752	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
intron-3CDS	ENST00000393614	ENST00000357640	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
intron-3CDS	ENST00000393614	ENST00000369752	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
intron-intron	ENST00000359172	ENST00000473682	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-
intron-intron	ENST00000393614	ENST00000473682	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000369799

AHCYL1

chr1

110527794

ENST00000357640

DENND2D

chr1

111737348

1689

487

1257

405

ENST00000369799

AHCYL1

chr1

110527794

ENST00000369752

DENND2D

chr1

111737348

1689

487

1257

405

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369799	ENST00000357640	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-	0.005534144	0.9944659
ENST00000369799	ENST00000369752	AHCYL1	chr1	110527794	+	DENND2D	chr1	111737348	-	0.005534144	0.9944659

Top

Fusion Genomic Features for AHCYL1-DENND2D

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for AHCYL1-DENND2D

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:110527794/chr1:111737348)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AHCYL1 O43865	DENND2D Q9H6A0
FUNCTION: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250\|UniProtKB:B5DFN2, ECO:0000250\|UniProtKB:Q80SW1, ECO:0000269\|PubMed:16769890, ECO:0000269\|PubMed:16793548, ECO:0000269\|PubMed:18829453, ECO:0000269\|PubMed:19224921, ECO:0000269\|PubMed:20584908, ECO:0000269\|PubMed:25237103, ECO:0000269\|PubMed:27995898}.	FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269\|PubMed:20937701}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DENND2D

chr1:110527794

chr1:111737348

ENST00000357640

226_359

215

472.0

Domain

cDENN

Tgene

DENND2D

chr1:110527794

chr1:111737348

ENST00000357640

361_445

215

472.0

Domain

dDENN

Tgene

DENND2D

chr1:110527794

chr1:111737348

ENST00000369752

226_359

212

469.0

Domain

cDENN

Tgene

DENND2D

chr1:110527794

chr1:111737348

ENST00000369752

361_445

212

469.0

Domain

dDENN

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000359172

318_322

484.0

Nucleotide binding

NAD

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000359172

397_399

484.0

Nucleotide binding

NAD

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000369799

318_322

531.0

Nucleotide binding

NAD

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000369799

397_399

531.0

Nucleotide binding

NAD

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000393614

318_322

484.0

Nucleotide binding

NAD

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000393614

397_399

484.0

Nucleotide binding

NAD

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000359172

281_448

484.0

Region

NAD binding

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000359172

520_530

484.0

Region

PDZ-binding

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000359172

65_92

484.0

Region

PEST

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000369799

281_448

531.0

Region

NAD binding

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000369799

520_530

531.0

Region

PDZ-binding

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000369799

65_92

531.0

Region

PEST

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000393614

281_448

484.0

Region

NAD binding

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000393614

520_530

484.0

Region

PDZ-binding

Hgene

AHCYL1

chr1:110527794

chr1:111737348

ENST00000393614

65_92

484.0

Region

PEST

Tgene

DENND2D

chr1:110527794

chr1:111737348

ENST00000357640

55_204

215

472.0

Domain

uDENN

Tgene

DENND2D

chr1:110527794

chr1:111737348

ENST00000369752

55_204

212

469.0

Domain

uDENN

Top

Fusion Gene Sequence for AHCYL1-DENND2D

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>3049_3049_1_AHCYL1-DENND2D_AHCYL1_chr1_110527794_ENST00000369799_DENND2D_chr1_111737348_ENST00000357640_length(transcript)=1689nt_BP=487nt
CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC
GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC
TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA
TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG
CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA
CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAG
TTCTCTATTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGG
TCTCAGCACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGA
GAGCCTTCTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGA
AGAGGTCCTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGA
CATCTTAGACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTT
TGTCAAGATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCT
GACCTCCAAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAA
TCCTCCTGCAGGCTATTTCCAACAGAAAATACTTGAATATGAGGAACAGAAGAAACAGAAGAAACCAAGGGAAAAAACTGTGAAATAAGA
GCTGTGGTGAATAAGAATGACTAGAGCTACACACCATTTCTGGACTTCAGCCCCTGCCAGTGTGGCAGGATCAGCAAAACTGTCAGCTCC
CAAAATCCATATCCTCACTCTGAGTCTTGGTATCCAGGTATTGCTTCAAACTGGTGTCTGAGATTTGGATCCCTGGTATTGATTTCTCAG
GACTTTGGAGGGCTCTGACACCATGCTCACAGAACTGGGCTCAGAGCTCCATTTTTTGCAGAGGTGACACAGGTAGGAAACAGTAGTACA
TGTGTTGTAGACACTTGGTTAGAAGCTGCTGCAACTGCCCTCTCCCATCATTATAACATCTTCAACACAGAACACACTTTGTGGTCGAAA

>3049_3049_1_AHCYL1-DENND2D_AHCYL1_chr1_110527794_ENST00000369799_DENND2D_chr1_111737348_ENST00000357640_length(amino acids)=405AA_BP=149
MPVLDVASPPSTLALRACLRTAEVAARAGRSSELLFWFSCGRRRCPAALGCRTDKAWATAPQKPTQLDAGAGRRVGDRVSEGAARAGGRA
PEGERGGGGGSAAGRAGRGMSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKFISLTRPLDSHLEHVDFSSLLHCLSFEQILQ
IFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFL
MSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFV

--------------------------------------------------------------
>3049_3049_2_AHCYL1-DENND2D_AHCYL1_chr1_110527794_ENST00000369799_DENND2D_chr1_111737348_ENST00000369752_length(transcript)=1689nt_BP=487nt
CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC
GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC
TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA
TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG
CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA
CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAG
TTCTCTATTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGG
TCTCAGCACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGA
GAGCCTTCTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGA
AGAGGTCCTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGA
CATCTTAGACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTT
TGTCAAGATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCT
GACCTCCAAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAA
TCCTCCTGCAGGCTATTTCCAACAGAAAATACTTGAATATGAGGAACAGAAGAAACAGAAGAAACCAAGGGAAAAAACTGTGAAATAAGA
GCTGTGGTGAATAAGAATGACTAGAGCTACACACCATTTCTGGACTTCAGCCCCTGCCAGTGTGGCAGGATCAGCAAAACTGTCAGCTCC
CAAAATCCATATCCTCACTCTGAGTCTTGGTATCCAGGTATTGCTTCAAACTGGTGTCTGAGATTTGGATCCCTGGTATTGATTTCTCAG
GACTTTGGAGGGCTCTGACACCATGCTCACAGAACTGGGCTCAGAGCTCCATTTTTTGCAGAGGTGACACAGGTAGGAAACAGTAGTACA
TGTGTTGTAGACACTTGGTTAGAAGCTGCTGCAACTGCCCTCTCCCATCATTATAACATCTTCAACACAGAACACACTTTGTGGTCGAAA

>3049_3049_2_AHCYL1-DENND2D_AHCYL1_chr1_110527794_ENST00000369799_DENND2D_chr1_111737348_ENST00000369752_length(amino acids)=405AA_BP=149
MPVLDVASPPSTLALRACLRTAEVAARAGRSSELLFWFSCGRRRCPAALGCRTDKAWATAPQKPTQLDAGAGRRVGDRVSEGAARAGGRA
PEGERGGGGGSAAGRAGRGMSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKFISLTRPLDSHLEHVDFSSLLHCLSFEQILQ
IFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFL
MSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AHCYL1-DENND2D

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	AHCYL1	chr1:110527794	chr1:111737348	ENST00000359172	+	1	17	138_201	0	484.0	BCL2L10
Hgene	AHCYL1	chr1:110527794	chr1:111737348	ENST00000369799	+	1	17	138_201	40.0	531.0	BCL2L10
Hgene	AHCYL1	chr1:110527794	chr1:111737348	ENST00000393614	+	1	17	138_201	0	484.0	BCL2L10

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AHCYL1-DENND2D

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AHCYL1-DENND2D

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source