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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FKBP5-SNRPB2 (FusionGDB2 ID:30516)

Fusion Gene Summary for FKBP5-SNRPB2

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP5-SNRPB2
Fusion gene ID: 30516
HgeneTgene
Gene symbol

FKBP5

SNRPB2

Gene ID

2289

6629

Gene nameFKBP prolyl isomerase 5small nuclear ribonucleoprotein polypeptide B2
SynonymsAIG6|FKBP51|FKBP54|P54|PPIase|Ptg-10Msl1|U2B''
Cytomap

6p21.31

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP551 kDa FK506-binding protein51 kDa FKBP54 kDa progesterone receptor-associated immunophilinFF1 antigenFK506 binding protein 5FKBP-51HSP90-binding immunophilinPPIase FKBP5T-cell FK506-binding proteinandrogU2 small nuclear ribonucleoprotein B''U2 snRNP B''small nuclear ribonucleoprotein polypeptide B
Modification date2020032920200313
UniProtAcc

Q13451

.
Ensembl transtripts involved in fusion geneENST00000357266, ENST00000536438, 
ENST00000539068, ENST00000542713, 
ENST00000540787, 
ENST00000478522, 
ENST00000246071, ENST00000377943, 
Fusion gene scores* DoF score16 X 11 X 9=15841 X 1 X 1=1
# samples 161
** MAII scorelog2(16/1584*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: FKBP5 [Title/Abstract] AND SNRPB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFKBP5(35610497)-SNRPB2(16717906), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFKBP5

GO:0061077

chaperone-mediated protein folding

11350175

TgeneSNRPB2

GO:0000398

mRNA splicing, via spliceosome

28076346|28781166


check buttonFusion gene breakpoints across FKBP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNRPB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8209-01AFKBP5chr6

35610497

-SNRPB2chr20

16717906

+


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Fusion Gene ORF analysis for FKBP5-SNRPB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357266ENST00000478522FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
5CDS-intronENST00000536438ENST00000478522FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
5CDS-intronENST00000539068ENST00000478522FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
5CDS-intronENST00000542713ENST00000478522FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000357266ENST00000246071FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000357266ENST00000377943FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000536438ENST00000246071FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000536438ENST00000377943FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000539068ENST00000246071FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000539068ENST00000377943FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000542713ENST00000246071FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
In-frameENST00000542713ENST00000377943FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
intron-3CDSENST00000540787ENST00000246071FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
intron-3CDSENST00000540787ENST00000377943FKBP5chr6

35610497

-SNRPB2chr20

16717906

+
intron-intronENST00000540787ENST00000478522FKBP5chr6

35610497

-SNRPB2chr20

16717906

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000539068FKBP5chr635610497-ENST00000377943SNRPB2chr2016717906+1520308203748181
ENST00000539068FKBP5chr635610497-ENST00000246071SNRPB2chr2016717906+1520308203748181
ENST00000536438FKBP5chr635610497-ENST00000377943SNRPB2chr2016717906+1633421316861181
ENST00000536438FKBP5chr635610497-ENST00000246071SNRPB2chr2016717906+1633421316861181
ENST00000357266FKBP5chr635610497-ENST00000377943SNRPB2chr2016717906+1470258153698181
ENST00000357266FKBP5chr635610497-ENST00000246071SNRPB2chr2016717906+1470258153698181
ENST00000542713FKBP5chr635610497-ENST00000377943SNRPB2chr2016717906+1475263158703181
ENST00000542713FKBP5chr635610497-ENST00000246071SNRPB2chr2016717906+1475263158703181

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539068ENST00000377943FKBP5chr635610497-SNRPB2chr2016717906+0.0006909680.99930906
ENST00000539068ENST00000246071FKBP5chr635610497-SNRPB2chr2016717906+0.0006909680.99930906
ENST00000536438ENST00000377943FKBP5chr635610497-SNRPB2chr2016717906+0.0010681480.9989318
ENST00000536438ENST00000246071FKBP5chr635610497-SNRPB2chr2016717906+0.0010681480.9989318
ENST00000357266ENST00000377943FKBP5chr635610497-SNRPB2chr2016717906+0.0007132080.99928683
ENST00000357266ENST00000246071FKBP5chr635610497-SNRPB2chr2016717906+0.0007132080.99928683
ENST00000542713ENST00000377943FKBP5chr635610497-SNRPB2chr2016717906+0.0008285850.9991715
ENST00000542713ENST00000246071FKBP5chr635610497-SNRPB2chr2016717906+0.0008285850.9991715

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Fusion Genomic Features for FKBP5-SNRPB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FKBP5chr635610496-SNRPB2chr2016717905+0.0001505210.99984944
FKBP5chr635610496-SNRPB2chr2016717905+0.0001505210.99984944

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FKBP5-SNRPB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:35610497/chr20:16717906)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP5

Q13451

.
FUNCTION: Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:28147277}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSNRPB2chr6:35610497chr20:16717906ENST0000024607127151_22579226.0DomainRRM 2
TgeneSNRPB2chr6:35610497chr20:16717906ENST0000037794327151_22579226.0DomainRRM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP5chr6:35610497chr20:16717906ENST00000357266-211157_24335458.0DomainPPIase FKBP-type 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000357266-21142_13035458.0DomainPPIase FKBP-type 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000536438-312157_24335458.0DomainPPIase FKBP-type 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000536438-31242_13035458.0DomainPPIase FKBP-type 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000539068-211157_24335458.0DomainPPIase FKBP-type 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000539068-21142_13035458.0DomainPPIase FKBP-type 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000542713-27157_24335269.0DomainPPIase FKBP-type 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000542713-2742_13035269.0DomainPPIase FKBP-type 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000357266-211268_30135458.0RepeatNote=TPR 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000357266-211317_35035458.0RepeatNote=TPR 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000357266-211351_38435458.0RepeatNote=TPR 3
HgeneFKBP5chr6:35610497chr20:16717906ENST00000536438-312268_30135458.0RepeatNote=TPR 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000536438-312317_35035458.0RepeatNote=TPR 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000536438-312351_38435458.0RepeatNote=TPR 3
HgeneFKBP5chr6:35610497chr20:16717906ENST00000539068-211268_30135458.0RepeatNote=TPR 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000539068-211317_35035458.0RepeatNote=TPR 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000539068-211351_38435458.0RepeatNote=TPR 3
HgeneFKBP5chr6:35610497chr20:16717906ENST00000542713-27268_30135269.0RepeatNote=TPR 1
HgeneFKBP5chr6:35610497chr20:16717906ENST00000542713-27317_35035269.0RepeatNote=TPR 2
HgeneFKBP5chr6:35610497chr20:16717906ENST00000542713-27351_38435269.0RepeatNote=TPR 3
TgeneSNRPB2chr6:35610497chr20:16717906ENST00000246071277_8679226.0DomainRRM 1
TgeneSNRPB2chr6:35610497chr20:16717906ENST00000377943277_8679226.0DomainRRM 1


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Fusion Gene Sequence for FKBP5-SNRPB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30516_30516_1_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000357266_SNRPB2_chr20_16717906_ENST00000246071_length(transcript)=1470nt_BP=258nt
GGGCCGGCTCGCGGGCGCTGCCAGTCTCGGGCGGCGGTGTCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAAGGGTTAGCGGAGCACGG
GCAAGGCGGAGAGTGACGGAGTCGGCGAGCCCCCGCGGCGACAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAAC
AATGAAGAAAGCCCCACAGCCACTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATACAGTAT
GCAAAAACAGATTCGGATATAATATCAAAAATGCGTGGAACTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAACTGTG
GAACAGACTGCAACAACCACAAACAAAAAGCCTGGCCAGGGAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATCCTCAG
GTCCCTGATTACCCTCCAAACTATATTTTATTCCTTAATAACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTAATCAG
TTCCCTGGCTTCAAGGAAGTACGTCTGGTACCAGGGAGGCATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAGCTGCC
AGGGATGCTTTACAGGGATTTAAGATCACACCGTCCCATGCTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGTCTTTA
AAAGACTTGGTGTTATTTACAGTGTTTGTTTTGATAACATTTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGTGAAAT
TTTTGTGAAGGACTTAAATTATCCAGTGTTTCTTTAGCCTTGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACTTTTAT
TTGTATTCTGTGTATATAATGCTTTCTTGATTGACCCATCTCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTTATAAA
CTTGTGTAATAGGATGCTTTTCTAGTGTTACTTTGGAGGAGCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAAAATTA
GATCACAGAAGCTAGTAGATGACTGTTGTATTAATGGTAACAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGATCTAA
ATTTGATCTTTGTATCCTTTTAAGAAATGAATATATTATTTTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAAATAAA
GGCTGTTCTTACTGTTTACTGAGAAAACAGAAAGGGAATGCTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAGGACTG
TTCTAAGGTTAATATGCAATCTCTTTATTGAAAGACCTCCAGGGTAAAAATTTTTTGATCTATAGTCTCTTTTCCCCCTTAAGACAAATA

>30516_30516_1_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000357266_SNRPB2_chr20_16717906_ENST00000246071_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------
>30516_30516_2_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000357266_SNRPB2_chr20_16717906_ENST00000377943_length(transcript)=1470nt_BP=258nt
GGGCCGGCTCGCGGGCGCTGCCAGTCTCGGGCGGCGGTGTCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAAGGGTTAGCGGAGCACGG
GCAAGGCGGAGAGTGACGGAGTCGGCGAGCCCCCGCGGCGACAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAAC
AATGAAGAAAGCCCCACAGCCACTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATACAGTAT
GCAAAAACAGATTCGGATATAATATCAAAAATGCGTGGAACTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAACTGTG
GAACAGACTGCAACAACCACAAACAAAAAGCCTGGCCAGGGAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATCCTCAG
GTCCCTGATTACCCTCCAAACTATATTTTATTCCTTAATAACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTAATCAG
TTCCCTGGCTTCAAGGAAGTACGTCTGGTACCAGGGAGGCATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAGCTGCC
AGGGATGCTTTACAGGGATTTAAGATCACACCGTCCCATGCTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGTCTTTA
AAAGACTTGGTGTTATTTACAGTGTTTGTTTTGATAACATTTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGTGAAAT
TTTTGTGAAGGACTTAAATTATCCAGTGTTTCTTTAGCCTTGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACTTTTAT
TTGTATTCTGTGTATATAATGCTTTCTTGATTGACCCATCTCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTTATAAA
CTTGTGTAATAGGATGCTTTTCTAGTGTTACTTTGGAGGAGCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAAAATTA
GATCACAGAAGCTAGTAGATGACTGTTGTATTAATGGTAACAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGATCTAA
ATTTGATCTTTGTATCCTTTTAAGAAATGAATATATTATTTTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAAATAAA
GGCTGTTCTTACTGTTTACTGAGAAAACAGAAAGGGAATGCTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAGGACTG
TTCTAAGGTTAATATGCAATCTCTTTATTGAAAGACCTCCAGGGTAAAAATTTTTTGATCTATAGTCTCTTTTCCCCCTTAAGACAAATA

>30516_30516_2_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000357266_SNRPB2_chr20_16717906_ENST00000377943_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------
>30516_30516_3_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000536438_SNRPB2_chr20_16717906_ENST00000246071_length(transcript)=1633nt_BP=421nt
AGAACAAACTCCTACCTCTGTTTGCAACTAAGAGTTACATCCCCCATGCCAAGACCTTCCGAGGCGTCCCAAAGGGGGAAATTCCTCGCT
GCCGGACTGCGCCCACCCTTGAGGACCTCACATTCTCTTTGGGCAGAGCGGAAGCCAGACAGAGACAGGGACTACGAAGCGACAATCCCC
AGCCCTGTGTGTGCAAGGAGCCCCCGAGGGGCAGGCAGCCACGCTGCAGAAGGCTAGACTCTCCGACCCCCAGGGAGCCTGGTGTGGGCT
GCAGGGACAGAACGCTTCTCAGAGGAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCCCCAC
AGCCACTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATACAGTATGCAAAAACAGATTCGGA
TATAATATCAAAAATGCGTGGAACTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAACTGTGGAACAGACTGCAACAAC
CACAAACAAAAAGCCTGGCCAGGGAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATCCTCAGGTCCCTGATTACCCTCC
AAACTATATTTTATTCCTTAATAACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTAATCAGTTCCCTGGCTTCAAGGA
AGTACGTCTGGTACCAGGGAGGCATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAGCTGCCAGGGATGCTTTACAGGG
ATTTAAGATCACACCGTCCCATGCTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGTCTTTAAAAGACTTGGTGTTATT
TACAGTGTTTGTTTTGATAACATTTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGTGAAATTTTTGTGAAGGACTTAA
ATTATCCAGTGTTTCTTTAGCCTTGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACTTTTATTTGTATTCTGTGTATAT
AATGCTTTCTTGATTGACCCATCTCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTTATAAACTTGTGTAATAGGATGC
TTTTCTAGTGTTACTTTGGAGGAGCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAAAATTAGATCACAGAAGCTAGTA
GATGACTGTTGTATTAATGGTAACAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGATCTAAATTTGATCTTTGTATCC
TTTTAAGAAATGAATATATTATTTTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAAATAAAGGCTGTTCTTACTGTTT
ACTGAGAAAACAGAAAGGGAATGCTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAGGACTGTTCTAAGGTTAATATGC
AATCTCTTTATTGAAAGACCTCCAGGGTAAAAATTTTTTGATCTATAGTCTCTTTTCCCCCTTAAGACAAATAGACTGATTAATAAAGAG

>30516_30516_3_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000536438_SNRPB2_chr20_16717906_ENST00000246071_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------
>30516_30516_4_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000536438_SNRPB2_chr20_16717906_ENST00000377943_length(transcript)=1633nt_BP=421nt
AGAACAAACTCCTACCTCTGTTTGCAACTAAGAGTTACATCCCCCATGCCAAGACCTTCCGAGGCGTCCCAAAGGGGGAAATTCCTCGCT
GCCGGACTGCGCCCACCCTTGAGGACCTCACATTCTCTTTGGGCAGAGCGGAAGCCAGACAGAGACAGGGACTACGAAGCGACAATCCCC
AGCCCTGTGTGTGCAAGGAGCCCCCGAGGGGCAGGCAGCCACGCTGCAGAAGGCTAGACTCTCCGACCCCCAGGGAGCCTGGTGTGGGCT
GCAGGGACAGAACGCTTCTCAGAGGAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCCCCAC
AGCCACTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATACAGTATGCAAAAACAGATTCGGA
TATAATATCAAAAATGCGTGGAACTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAACTGTGGAACAGACTGCAACAAC
CACAAACAAAAAGCCTGGCCAGGGAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATCCTCAGGTCCCTGATTACCCTCC
AAACTATATTTTATTCCTTAATAACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTAATCAGTTCCCTGGCTTCAAGGA
AGTACGTCTGGTACCAGGGAGGCATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAGCTGCCAGGGATGCTTTACAGGG
ATTTAAGATCACACCGTCCCATGCTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGTCTTTAAAAGACTTGGTGTTATT
TACAGTGTTTGTTTTGATAACATTTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGTGAAATTTTTGTGAAGGACTTAA
ATTATCCAGTGTTTCTTTAGCCTTGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACTTTTATTTGTATTCTGTGTATAT
AATGCTTTCTTGATTGACCCATCTCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTTATAAACTTGTGTAATAGGATGC
TTTTCTAGTGTTACTTTGGAGGAGCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAAAATTAGATCACAGAAGCTAGTA
GATGACTGTTGTATTAATGGTAACAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGATCTAAATTTGATCTTTGTATCC
TTTTAAGAAATGAATATATTATTTTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAAATAAAGGCTGTTCTTACTGTTT
ACTGAGAAAACAGAAAGGGAATGCTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAGGACTGTTCTAAGGTTAATATGC
AATCTCTTTATTGAAAGACCTCCAGGGTAAAAATTTTTTGATCTATAGTCTCTTTTCCCCCTTAAGACAAATAGACTGATTAATAAAGAG

>30516_30516_4_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000536438_SNRPB2_chr20_16717906_ENST00000377943_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------
>30516_30516_5_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000539068_SNRPB2_chr20_16717906_ENST00000246071_length(transcript)=1520nt_BP=308nt
AGTCTCGGGCGGCGGTGTCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAAGGGTTAGCGGAGCACGGGCAAGGCGGAGAGTGACGGAGT
CGGCGAGCCCCCGCGGCGACAGGTACCGGCGCCATGGCCACGGAGATGGGGCGGCCGGCCGCGGCGCCCCGGGAGCCGAACGCCCTCCTT
CCAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCCCCACAGCCACTGTTGCTGAGCAGGGAG
AGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATACAGTATGCAAAAACAGATTCGGATATAATATCAAAAATGCGTGGAA
CTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAACTGTGGAACAGACTGCAACAACCACAAACAAAAAGCCTGGCCAGG
GAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATCCTCAGGTCCCTGATTACCCTCCAAACTATATTTTATTCCTTAATA
ACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTAATCAGTTCCCTGGCTTCAAGGAAGTACGTCTGGTACCAGGGAGGC
ATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAGCTGCCAGGGATGCTTTACAGGGATTTAAGATCACACCGTCCCATG
CTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGTCTTTAAAAGACTTGGTGTTATTTACAGTGTTTGTTTTGATAACAT
TTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGTGAAATTTTTGTGAAGGACTTAAATTATCCAGTGTTTCTTTAGCCT
TGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACTTTTATTTGTATTCTGTGTATATAATGCTTTCTTGATTGACCCATC
TCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTTATAAACTTGTGTAATAGGATGCTTTTCTAGTGTTACTTTGGAGGA
GCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAAAATTAGATCACAGAAGCTAGTAGATGACTGTTGTATTAATGGTAA
CAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGATCTAAATTTGATCTTTGTATCCTTTTAAGAAATGAATATATTATT
TTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAAATAAAGGCTGTTCTTACTGTTTACTGAGAAAACAGAAAGGGAATG
CTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAGGACTGTTCTAAGGTTAATATGCAATCTCTTTATTGAAAGACCTCC

>30516_30516_5_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000539068_SNRPB2_chr20_16717906_ENST00000246071_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------
>30516_30516_6_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000539068_SNRPB2_chr20_16717906_ENST00000377943_length(transcript)=1520nt_BP=308nt
AGTCTCGGGCGGCGGTGTCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAAGGGTTAGCGGAGCACGGGCAAGGCGGAGAGTGACGGAGT
CGGCGAGCCCCCGCGGCGACAGGTACCGGCGCCATGGCCACGGAGATGGGGCGGCCGGCCGCGGCGCCCCGGGAGCCGAACGCCCTCCTT
CCAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCCCCACAGCCACTGTTGCTGAGCAGGGAG
AGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATACAGTATGCAAAAACAGATTCGGATATAATATCAAAAATGCGTGGAA
CTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAACTGTGGAACAGACTGCAACAACCACAAACAAAAAGCCTGGCCAGG
GAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATCCTCAGGTCCCTGATTACCCTCCAAACTATATTTTATTCCTTAATA
ACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTAATCAGTTCCCTGGCTTCAAGGAAGTACGTCTGGTACCAGGGAGGC
ATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAGCTGCCAGGGATGCTTTACAGGGATTTAAGATCACACCGTCCCATG
CTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGTCTTTAAAAGACTTGGTGTTATTTACAGTGTTTGTTTTGATAACAT
TTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGTGAAATTTTTGTGAAGGACTTAAATTATCCAGTGTTTCTTTAGCCT
TGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACTTTTATTTGTATTCTGTGTATATAATGCTTTCTTGATTGACCCATC
TCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTTATAAACTTGTGTAATAGGATGCTTTTCTAGTGTTACTTTGGAGGA
GCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAAAATTAGATCACAGAAGCTAGTAGATGACTGTTGTATTAATGGTAA
CAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGATCTAAATTTGATCTTTGTATCCTTTTAAGAAATGAATATATTATT
TTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAAATAAAGGCTGTTCTTACTGTTTACTGAGAAAACAGAAAGGGAATG
CTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAGGACTGTTCTAAGGTTAATATGCAATCTCTTTATTGAAAGACCTCC

>30516_30516_6_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000539068_SNRPB2_chr20_16717906_ENST00000377943_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------
>30516_30516_7_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000542713_SNRPB2_chr20_16717906_ENST00000246071_length(transcript)=1475nt_BP=263nt
GATTCGGGCCGGCTCGCGGGCGCTGCCAGTCTCGGGCGGCGGTGTCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAAGGGTTAGCGGAG
CACGGGCAAGGCGGAGAGTGACGGAGTCGGCGAGCCCCCGCGGCGACAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCA
AGAACAATGAAGAAAGCCCCACAGCCACTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATAC
AGTATGCAAAAACAGATTCGGATATAATATCAAAAATGCGTGGAACTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAA
CTGTGGAACAGACTGCAACAACCACAAACAAAAAGCCTGGCCAGGGAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATC
CTCAGGTCCCTGATTACCCTCCAAACTATATTTTATTCCTTAATAACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTA
ATCAGTTCCCTGGCTTCAAGGAAGTACGTCTGGTACCAGGGAGGCATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAG
CTGCCAGGGATGCTTTACAGGGATTTAAGATCACACCGTCCCATGCTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGT
CTTTAAAAGACTTGGTGTTATTTACAGTGTTTGTTTTGATAACATTTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGT
GAAATTTTTGTGAAGGACTTAAATTATCCAGTGTTTCTTTAGCCTTGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACT
TTTATTTGTATTCTGTGTATATAATGCTTTCTTGATTGACCCATCTCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTT
ATAAACTTGTGTAATAGGATGCTTTTCTAGTGTTACTTTGGAGGAGCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAA
AATTAGATCACAGAAGCTAGTAGATGACTGTTGTATTAATGGTAACAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGA
TCTAAATTTGATCTTTGTATCCTTTTAAGAAATGAATATATTATTTTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAA
ATAAAGGCTGTTCTTACTGTTTACTGAGAAAACAGAAAGGGAATGCTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAG
GACTGTTCTAAGGTTAATATGCAATCTCTTTATTGAAAGACCTCCAGGGTAAAAATTTTTTGATCTATAGTCTCTTTTCCCCCTTAAGAC

>30516_30516_7_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000542713_SNRPB2_chr20_16717906_ENST00000246071_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------
>30516_30516_8_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000542713_SNRPB2_chr20_16717906_ENST00000377943_length(transcript)=1475nt_BP=263nt
GATTCGGGCCGGCTCGCGGGCGCTGCCAGTCTCGGGCGGCGGTGTCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAAGGGTTAGCGGAG
CACGGGCAAGGCGGAGAGTGACGGAGTCGGCGAGCCCCCGCGGCGACAGGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCA
AGAACAATGAAGAAAGCCCCACAGCCACTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGCGAATAC
AGTATGCAAAAACAGATTCGGATATAATATCAAAAATGCGTGGAACTTTTGCTGACAAAGAAAAGAAAAAAGAAAAGAAAAAAGCCAAAA
CTGTGGAACAGACTGCAACAACCACAAACAAAAAGCCTGGCCAGGGAACTCCAAATTCAGCTAATACCCAAGGAAATTCAACACCAAATC
CTCAGGTCCCTGATTACCCTCCAAACTATATTTTATTCCTTAATAACTTACCAGAAGAGACTAATGAGATGATGTTATCCATGCTGTTTA
ATCAGTTCCCTGGCTTCAAGGAAGTACGTCTGGTACCAGGGAGGCATGACATTGCTTTTGTTGAATTTGAAAATGATGGGCAGGCTGGAG
CTGCCAGGGATGCTTTACAGGGATTTAAGATCACACCGTCCCATGCTATGAAGATCACCTATGCCAAGAAATAACATTTGGGATAGTCGT
CTTTAAAAGACTTGGTGTTATTTACAGTGTTTGTTTTGATAACATTTGGCTGGGTCATTTTAATAGTTAGAGATGAGGAGGAGTAAAAGT
GAAATTTTTGTGAAGGACTTAAATTATCCAGTGTTTCTTTAGCCTTGGTGAACTATGAAATACGAAGGCCTTAATTTTGTACAATAAACT
TTTATTTGTATTCTGTGTATATAATGCTTTCTTGATTGACCCATCTCCCTATCATCAAATGACTTCTAGTCTAGAACACACTTAAGGTTT
ATAAACTTGTGTAATAGGATGCTTTTCTAGTGTTACTTTGGAGGAGCTAATTATACAACATCATTGAACCATTCAATAAAAGTTAAGTAA
AATTAGATCACAGAAGCTAGTAGATGACTGTTGTATTAATGGTAACAATGATTGTTCTGGGTATTAGAAGAAAATGAGACCCAGGCAGGA
TCTAAATTTGATCTTTGTATCCTTTTAAGAAATGAATATATTATTTTGCTGCTAGTAGGGATTCCACAAGTTTTCTTCATTCAGTATTAA
ATAAAGGCTGTTCTTACTGTTTACTGAGAAAACAGAAAGGGAATGCTATCTTCACACTTTGCATTTAATGCTGTTTCCTTCATGAGGCAG
GACTGTTCTAAGGTTAATATGCAATCTCTTTATTGAAAGACCTCCAGGGTAAAAATTTTTTGATCTATAGTCTCTTTTCCCCCTTAAGAC

>30516_30516_8_FKBP5-SNRPB2_FKBP5_chr6_35610497_ENST00000542713_SNRPB2_chr20_16717906_ENST00000377943_length(amino acids)=181AA_BP=35
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANT
QGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FKBP5-SNRPB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FKBP5-SNRPB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FKBP5-SNRPB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource