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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FKBP8-HAUS8 (FusionGDB2 ID:30528)

Fusion Gene Summary for FKBP8-HAUS8

Fusion gene summary

Fusion gene information	Fusion gene name: FKBP8-HAUS8
	Fusion gene ID: 30528
		Hgene	Tgene
	Gene symbol	FKBP8	HAUS8
	Gene ID	23770	93323
	Gene name	FKBP prolyl isomerase 8	HAUS augmin like complex subunit 8
	Synonyms	FKBP38\|FKBPr38	DGT4\|HICE1\|NY-SAR-48
	Cytomap	19p13.11	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	peptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFK506-binding protein 8FKBP-38FKBP-8PPIase FKBP8hFKBP38rotamase	HAUS augmin-like complex subunit 8HEC1/NDC80 interacting, centrosome associated 1HEC1/NDC80-interacting centrosome-associated protein 1Hec1-interacting and centrosome-associated 1sarcoma antigen NY-SAR-48
	Modification date	20200327	20200313
	UniProtAcc	Q14318	Q9BT25
	Ensembl transtripts involved in fusion gene	ENST00000222308, ENST00000453489, ENST00000596558, ENST00000597960, ENST00000608443, ENST00000610101,	ENST00000593360, ENST00000253669, ENST00000448593,
Fusion gene scores	* DoF score	12 X 15 X 5=900	7 X 8 X 6=336
	# samples	15	7
	** MAII score	log2(15/900*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/336*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FKBP8 [Title/Abstract] AND HAUS8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FKBP8(18652489)-HAUS8(17184145), # samples:3
Anticipated loss of major functional domain due to fusion event.	FKBP8-HAUS8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FKBP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HAUS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5KX-01A	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-

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Fusion Gene ORF analysis for FKBP8-HAUS8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000222308	ENST00000593360	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
5CDS-5UTR	ENST00000453489	ENST00000593360	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
5CDS-5UTR	ENST00000596558	ENST00000593360	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
5CDS-5UTR	ENST00000597960	ENST00000593360	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
5CDS-5UTR	ENST00000608443	ENST00000593360	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
5CDS-5UTR	ENST00000610101	ENST00000593360	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
Frame-shift	ENST00000453489	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
Frame-shift	ENST00000453489	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
Frame-shift	ENST00000596558	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
Frame-shift	ENST00000596558	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
Frame-shift	ENST00000597960	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
Frame-shift	ENST00000597960	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
In-frame	ENST00000222308	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
In-frame	ENST00000222308	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
In-frame	ENST00000608443	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
In-frame	ENST00000608443	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
In-frame	ENST00000610101	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-
In-frame	ENST00000610101	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000610101	FKBP8	chr19	18652489	-	ENST00000253669	HAUS8	chr19	17184145	-	1753	405	493	1608	371
ENST00000610101	FKBP8	chr19	18652489	-	ENST00000448593	HAUS8	chr19	17184145	-	1718	405	493	1605	370
ENST00000222308	FKBP8	chr19	18652489	-	ENST00000253669	HAUS8	chr19	17184145	-	1704	356	444	1559	371
ENST00000222308	FKBP8	chr19	18652489	-	ENST00000448593	HAUS8	chr19	17184145	-	1669	356	444	1556	370
ENST00000608443	FKBP8	chr19	18652489	-	ENST00000253669	HAUS8	chr19	17184145	-	1840	492	580	1695	371
ENST00000608443	FKBP8	chr19	18652489	-	ENST00000448593	HAUS8	chr19	17184145	-	1805	492	580	1692	370

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000610101	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-	0.002263883	0.9977361
ENST00000610101	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-	0.002698932	0.99730104
ENST00000222308	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-	0.00239172	0.9976083
ENST00000222308	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-	0.002793792	0.99720615
ENST00000608443	ENST00000253669	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-	0.002207686	0.99779236
ENST00000608443	ENST00000448593	FKBP8	chr19	18652489	-	HAUS8	chr19	17184145	-	0.002623978	0.9973761

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Fusion Genomic Features for FKBP8-HAUS8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FKBP8-HAUS8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:18652489/chr19:17184145)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FKBP8 Q14318	HAUS8 Q9BT25
FUNCTION: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269\|PubMed:12510191, ECO:0000269\|PubMed:15757646, ECO:0000269\|PubMed:16176796}.	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269\|PubMed:18362163, ECO:0000269\|PubMed:19369198, ECO:0000269\|PubMed:19427217}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000222308

22_92

413.0

Compositional bias

Note=Glu-rich

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000596558

22_92

413.0

Compositional bias

Note=Glu-rich

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000597960

22_92

414.0

Compositional bias

Note=Glu-rich

Tgene

HAUS8

chr19:18652489

chr19:17184145

ENST00000253669

156_208

411.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HAUS8

chr19:18652489

chr19:17184145

ENST00000448593

156_208

410.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HAUS8

chr19:18652489

chr19:17184145

ENST00000593360

156_208

350.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000222308

120_204

413.0

Domain

PPIase FKBP-type

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000596558

120_204

413.0

Domain

PPIase FKBP-type

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000597960

120_204

414.0

Domain

PPIase FKBP-type

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000222308

221_254

413.0

Repeat

Note=TPR 1

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000222308

272_305

413.0

Repeat

Note=TPR 2

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000222308

306_339

413.0

Repeat

Note=TPR 3

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000596558

221_254

413.0

Repeat

Note=TPR 1

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000596558

272_305

413.0

Repeat

Note=TPR 2

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000596558

306_339

413.0

Repeat

Note=TPR 3

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000597960

221_254

414.0

Repeat

Note=TPR 1

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000597960

272_305

414.0

Repeat

Note=TPR 2

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000597960

306_339

414.0

Repeat

Note=TPR 3

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000222308

390_410

413.0

Transmembrane

Helical

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000596558

390_410

413.0

Transmembrane

Helical

Hgene

FKBP8

chr19:18652489

chr19:17184145

ENST00000597960

390_410

414.0

Transmembrane

Helical

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Fusion Gene Sequence for FKBP8-HAUS8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>30528_30528_1_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000222308_HAUS8_chr19_17184145_ENST00000253669_length(transcript)=1704nt_BP=356nt
GGGGGCGCAGGACCCCAAGTGGGGGTCCCGGAGCCAGAGGGCCAATTCCTGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGA
GCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCGCTCGAGGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGA
GGAGGAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGCCACCGCTGGAGGACATGGGACAACCCCCGGCGGAGGAGGCTGAGCAGCC
TGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATGGAGCCCGAGCCCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGAAG
CCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAAGGATAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAG
TATGAAAAGAAGACAACCCAAAAGGCTCCTGCAGGAGATGGGTCACAGACCCGAGGGAAGATGTCTGAAGGTGGAAGGAAATCCAGCCTG
CTCCAGAAAAGCAAAGCAGATAGCAGTGGGGTCGGAAAGGGTGACCTGCAGTCCACGTTGCTGGAAGGGCATGGCACAGCTCCACCTGAC
CTGGATCTCTCTGCTATTAATGACAAAAGCATCGTCAAAAAGACGCCACAGTTAGCAAAAACAATATCAAAGAAACCTGAGTCAACATCA
TTTTCTGCCCCTCGGAAAAAGAGCCCGGATTTATCTGAAGCAATGGAAATGATGGAGTCTCAGACACTACTGCTGACGCTACTATCCGTA
AAGATGGAGAACAATCTTGCTGAGTTTGAAAGAAGGGCAGAAAAGAATTTATTAATAATGTGTAAGGAGAAGGAGAAGCTACAGAAAAAG
GCCCACGAGCTGAAGCGCAGGCTTCTCCTCTCTCAGAGGAAGCGGGAGCTGGCAGATGTCCTGGATGCCCAGATCGAGATGCTCAGCCCC
TTCGAGGCAGTGGCCACACGCTTCAAGGAGCAATACAGGACATTCGCCACGGCCCTGGACACTACCAGGCACGAGCTGCCCGTGAGGTCC
ATCCACCTGGAGGGAGATGGGCAGCAGCTCTTAGACGCCCTGCAGCATGAACTGGTGACCACTCAGCGCCTCCTGGGAGAACTTGATGTT
GGTGATTCGGAAGAAAATGTGCAGGTGCTGGACTTACTGAGCGAACTCAAGGACGTGACGGCGAAAAAGGACCTTGAGCTCCGAAGGAGC
TTTGCCCAGGTGCTGGAACTCTCCGCAGAGGCAAGCAAAGAGGCAGCCTTGGCAAACCAGGAAGTCTGGGAAGAGACCCAGGGCATGGCG
CCCCCCAGCCGGTGGTATTTCAATCAAGACAGTGCCTGCAGAGAATCTGGGGGAGCACCCAAGAACACGCCCCTGTCTGAGGACGACAAC
CCGGGTGCCTCGTCAGCCCCCGCTCAGGCCACGTTCATCAGCCCAAGCGAAGATTTTTCTTCAAGCAGCCAGGCAGAAGTCCCGCCCTCT
CTCTCTCGTTCAGGGAGGGACTTGTCATGACTCATGGTTACATTCAGGATACTTGAGCACTTTATATACTACCGTAGCACTGTAGCTATT

>30528_30528_1_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000222308_HAUS8_chr19_17184145_ENST00000253669_length(amino acids)=371AA_BP=
MQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKADSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPES
TSFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEML
SPFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELR
RSFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVP

--------------------------------------------------------------
>30528_30528_2_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000222308_HAUS8_chr19_17184145_ENST00000448593_length(transcript)=1669nt_BP=356nt
GGGGGCGCAGGACCCCAAGTGGGGGTCCCGGAGCCAGAGGGCCAATTCCTGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGA
GCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCGCTCGAGGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGA
GGAGGAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGCCACCGCTGGAGGACATGGGACAACCCCCGGCGGAGGAGGCTGAGCAGCC
TGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATGGAGCCCGAGCCCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGAAG
CCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAAGGATAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAG
TATGAAAAGAAGACAACCCAAAAGGCTCCTGCAGGAGATGGGTCACAGACCCGAGGGAAGATGTCTGAAGGTGGAAGGAAATCCAGCCTG
CTCCAGAAAAGCAAAGATAGCAGTGGGGTCGGAAAGGGTGACCTGCAGTCCACGTTGCTGGAAGGGCATGGCACAGCTCCACCTGACCTG
GATCTCTCTGCTATTAATGACAAAAGCATCGTCAAAAAGACGCCACAGTTAGCAAAAACAATATCAAAGAAACCTGAGTCAACATCATTT
TCTGCCCCTCGGAAAAAGAGCCCGGATTTATCTGAAGCAATGGAAATGATGGAGTCTCAGACACTACTGCTGACGCTACTATCCGTAAAG
ATGGAGAACAATCTTGCTGAGTTTGAAAGAAGGGCAGAAAAGAATTTATTAATAATGTGTAAGGAGAAGGAGAAGCTACAGAAAAAGGCC
CACGAGCTGAAGCGCAGGCTTCTCCTCTCTCAGAGGAAGCGGGAGCTGGCAGATGTCCTGGATGCCCAGATCGAGATGCTCAGCCCCTTC
GAGGCAGTGGCCACACGCTTCAAGGAGCAATACAGGACATTCGCCACGGCCCTGGACACTACCAGGCACGAGCTGCCCGTGAGGTCCATC
CACCTGGAGGGAGATGGGCAGCAGCTCTTAGACGCCCTGCAGCATGAACTGGTGACCACTCAGCGCCTCCTGGGAGAACTTGATGTTGGT
GATTCGGAAGAAAATGTGCAGGTGCTGGACTTACTGAGCGAACTCAAGGACGTGACGGCGAAAAAGGACCTTGAGCTCCGAAGGAGCTTT
GCCCAGGTGCTGGAACTCTCCGCAGAGGCAAGCAAAGAGGCAGCCTTGGCAAACCAGGAAGTCTGGGAAGAGACCCAGGGCATGGCGCCC
CCCAGCCGGTGGTATTTCAATCAAGACAGTGCCTGCAGAGAATCTGGGGGAGCACCCAAGAACACGCCCCTGTCTGAGGACGACAACCCG
GGTGCCTCGTCAGCCCCCGCTCAGGCCACGTTCATCAGCCCAAGCGAAGATTTTTCTTCAAGCAGCCAGGCAGAAGTCCCGCCCTCTCTC
TCTCGTTCAGGGAGGGACTTGTCATGACTCATGGTTACATTCAGGATACTTGAGCACTTTATATACTACCGTAGCACTGTAGCTATTTTT

>30528_30528_2_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000222308_HAUS8_chr19_17184145_ENST00000448593_length(amino acids)=370AA_BP=
MQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKDSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPEST
SFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEMLS
PFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRR
SFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVPP

--------------------------------------------------------------
>30528_30528_3_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000608443_HAUS8_chr19_17184145_ENST00000253669_length(transcript)=1840nt_BP=492nt
ACGCCCGGGACGGACGTCTGCATGAGCCAACGGGTGCGGCAGTCGCGGCAGCGGCGGCCAATGGGCACGGCAGGGGCGGGGCCAAGCGGC
CGAACCTGGTTCCCGAGGCGCGGCGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCCCAAGTGGGGGTCCCGGAGCCAGAGGGCCA
ATTCCTGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCGCTCGAGGACT
TCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAGGAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGCCAC
CGCTGGAGGACATGGGACAACCCCCGGCGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATGGAGCCCGAGC
CCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAAGGA
TAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGCTCCTGCAGGAGATGGGTC
ACAGACCCGAGGGAAGATGTCTGAAGGTGGAAGGAAATCCAGCCTGCTCCAGAAAAGCAAAGCAGATAGCAGTGGGGTCGGAAAGGGTGA
CCTGCAGTCCACGTTGCTGGAAGGGCATGGCACAGCTCCACCTGACCTGGATCTCTCTGCTATTAATGACAAAAGCATCGTCAAAAAGAC
GCCACAGTTAGCAAAAACAATATCAAAGAAACCTGAGTCAACATCATTTTCTGCCCCTCGGAAAAAGAGCCCGGATTTATCTGAAGCAAT
GGAAATGATGGAGTCTCAGACACTACTGCTGACGCTACTATCCGTAAAGATGGAGAACAATCTTGCTGAGTTTGAAAGAAGGGCAGAAAA
GAATTTATTAATAATGTGTAAGGAGAAGGAGAAGCTACAGAAAAAGGCCCACGAGCTGAAGCGCAGGCTTCTCCTCTCTCAGAGGAAGCG
GGAGCTGGCAGATGTCCTGGATGCCCAGATCGAGATGCTCAGCCCCTTCGAGGCAGTGGCCACACGCTTCAAGGAGCAATACAGGACATT
CGCCACGGCCCTGGACACTACCAGGCACGAGCTGCCCGTGAGGTCCATCCACCTGGAGGGAGATGGGCAGCAGCTCTTAGACGCCCTGCA
GCATGAACTGGTGACCACTCAGCGCCTCCTGGGAGAACTTGATGTTGGTGATTCGGAAGAAAATGTGCAGGTGCTGGACTTACTGAGCGA
ACTCAAGGACGTGACGGCGAAAAAGGACCTTGAGCTCCGAAGGAGCTTTGCCCAGGTGCTGGAACTCTCCGCAGAGGCAAGCAAAGAGGC
AGCCTTGGCAAACCAGGAAGTCTGGGAAGAGACCCAGGGCATGGCGCCCCCCAGCCGGTGGTATTTCAATCAAGACAGTGCCTGCAGAGA
ATCTGGGGGAGCACCCAAGAACACGCCCCTGTCTGAGGACGACAACCCGGGTGCCTCGTCAGCCCCCGCTCAGGCCACGTTCATCAGCCC
AAGCGAAGATTTTTCTTCAAGCAGCCAGGCAGAAGTCCCGCCCTCTCTCTCTCGTTCAGGGAGGGACTTGTCATGACTCATGGTTACATT
CAGGATACTTGAGCACTTTATATACTACCGTAGCACTGTAGCTATTTTTTATGTGATAATCTTGTTTGATAAAAAAGTAAACCTGTTTTG

>30528_30528_3_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000608443_HAUS8_chr19_17184145_ENST00000253669_length(amino acids)=371AA_BP=
MQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKADSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPES
TSFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEML
SPFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELR
RSFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVP

--------------------------------------------------------------
>30528_30528_4_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000608443_HAUS8_chr19_17184145_ENST00000448593_length(transcript)=1805nt_BP=492nt
ACGCCCGGGACGGACGTCTGCATGAGCCAACGGGTGCGGCAGTCGCGGCAGCGGCGGCCAATGGGCACGGCAGGGGCGGGGCCAAGCGGC
CGAACCTGGTTCCCGAGGCGCGGCGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCCCAAGTGGGGGTCCCGGAGCCAGAGGGCCA
ATTCCTGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCGCTCGAGGACT
TCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAGGAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGCCAC
CGCTGGAGGACATGGGACAACCCCCGGCGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATGGAGCCCGAGC
CCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAAGGA
TAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGCTCCTGCAGGAGATGGGTC
ACAGACCCGAGGGAAGATGTCTGAAGGTGGAAGGAAATCCAGCCTGCTCCAGAAAAGCAAAGATAGCAGTGGGGTCGGAAAGGGTGACCT
GCAGTCCACGTTGCTGGAAGGGCATGGCACAGCTCCACCTGACCTGGATCTCTCTGCTATTAATGACAAAAGCATCGTCAAAAAGACGCC
ACAGTTAGCAAAAACAATATCAAAGAAACCTGAGTCAACATCATTTTCTGCCCCTCGGAAAAAGAGCCCGGATTTATCTGAAGCAATGGA
AATGATGGAGTCTCAGACACTACTGCTGACGCTACTATCCGTAAAGATGGAGAACAATCTTGCTGAGTTTGAAAGAAGGGCAGAAAAGAA
TTTATTAATAATGTGTAAGGAGAAGGAGAAGCTACAGAAAAAGGCCCACGAGCTGAAGCGCAGGCTTCTCCTCTCTCAGAGGAAGCGGGA
GCTGGCAGATGTCCTGGATGCCCAGATCGAGATGCTCAGCCCCTTCGAGGCAGTGGCCACACGCTTCAAGGAGCAATACAGGACATTCGC
CACGGCCCTGGACACTACCAGGCACGAGCTGCCCGTGAGGTCCATCCACCTGGAGGGAGATGGGCAGCAGCTCTTAGACGCCCTGCAGCA
TGAACTGGTGACCACTCAGCGCCTCCTGGGAGAACTTGATGTTGGTGATTCGGAAGAAAATGTGCAGGTGCTGGACTTACTGAGCGAACT
CAAGGACGTGACGGCGAAAAAGGACCTTGAGCTCCGAAGGAGCTTTGCCCAGGTGCTGGAACTCTCCGCAGAGGCAAGCAAAGAGGCAGC
CTTGGCAAACCAGGAAGTCTGGGAAGAGACCCAGGGCATGGCGCCCCCCAGCCGGTGGTATTTCAATCAAGACAGTGCCTGCAGAGAATC
TGGGGGAGCACCCAAGAACACGCCCCTGTCTGAGGACGACAACCCGGGTGCCTCGTCAGCCCCCGCTCAGGCCACGTTCATCAGCCCAAG
CGAAGATTTTTCTTCAAGCAGCCAGGCAGAAGTCCCGCCCTCTCTCTCTCGTTCAGGGAGGGACTTGTCATGACTCATGGTTACATTCAG
GATACTTGAGCACTTTATATACTACCGTAGCACTGTAGCTATTTTTTATGTGATAATCTTGTTTGATAAAAAAGTAAACCTGTTTTGCAA

>30528_30528_4_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000608443_HAUS8_chr19_17184145_ENST00000448593_length(amino acids)=370AA_BP=
MQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKDSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPEST
SFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEMLS
PFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRR
SFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVPP

--------------------------------------------------------------
>30528_30528_5_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000610101_HAUS8_chr19_17184145_ENST00000253669_length(transcript)=1753nt_BP=405nt
GGCCGAACCTGGTTCCCGAGGCGCGGCGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCCCAAGTGGGGGTCCCGGAGCCAGAGGG
CCAATTCCTGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCGCTCGAGG
ACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAGGAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGC
CACCGCTGGAGGACATGGGACAACCCCCGGCGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATGGAGCCCG
AGCCCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAA
GGATAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGCTCCTGCAGGAGATGG
GTCACAGACCCGAGGGAAGATGTCTGAAGGTGGAAGGAAATCCAGCCTGCTCCAGAAAAGCAAAGCAGATAGCAGTGGGGTCGGAAAGGG
TGACCTGCAGTCCACGTTGCTGGAAGGGCATGGCACAGCTCCACCTGACCTGGATCTCTCTGCTATTAATGACAAAAGCATCGTCAAAAA
GACGCCACAGTTAGCAAAAACAATATCAAAGAAACCTGAGTCAACATCATTTTCTGCCCCTCGGAAAAAGAGCCCGGATTTATCTGAAGC
AATGGAAATGATGGAGTCTCAGACACTACTGCTGACGCTACTATCCGTAAAGATGGAGAACAATCTTGCTGAGTTTGAAAGAAGGGCAGA
AAAGAATTTATTAATAATGTGTAAGGAGAAGGAGAAGCTACAGAAAAAGGCCCACGAGCTGAAGCGCAGGCTTCTCCTCTCTCAGAGGAA
GCGGGAGCTGGCAGATGTCCTGGATGCCCAGATCGAGATGCTCAGCCCCTTCGAGGCAGTGGCCACACGCTTCAAGGAGCAATACAGGAC
ATTCGCCACGGCCCTGGACACTACCAGGCACGAGCTGCCCGTGAGGTCCATCCACCTGGAGGGAGATGGGCAGCAGCTCTTAGACGCCCT
GCAGCATGAACTGGTGACCACTCAGCGCCTCCTGGGAGAACTTGATGTTGGTGATTCGGAAGAAAATGTGCAGGTGCTGGACTTACTGAG
CGAACTCAAGGACGTGACGGCGAAAAAGGACCTTGAGCTCCGAAGGAGCTTTGCCCAGGTGCTGGAACTCTCCGCAGAGGCAAGCAAAGA
GGCAGCCTTGGCAAACCAGGAAGTCTGGGAAGAGACCCAGGGCATGGCGCCCCCCAGCCGGTGGTATTTCAATCAAGACAGTGCCTGCAG
AGAATCTGGGGGAGCACCCAAGAACACGCCCCTGTCTGAGGACGACAACCCGGGTGCCTCGTCAGCCCCCGCTCAGGCCACGTTCATCAG
CCCAAGCGAAGATTTTTCTTCAAGCAGCCAGGCAGAAGTCCCGCCCTCTCTCTCTCGTTCAGGGAGGGACTTGTCATGACTCATGGTTAC
ATTCAGGATACTTGAGCACTTTATATACTACCGTAGCACTGTAGCTATTTTTTATGTGATAATCTTGTTTGATAAAAAAGTAAACCTGTT

>30528_30528_5_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000610101_HAUS8_chr19_17184145_ENST00000253669_length(amino acids)=371AA_BP=
MQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKADSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPES
TSFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEML
SPFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELR
RSFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVP

--------------------------------------------------------------
>30528_30528_6_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000610101_HAUS8_chr19_17184145_ENST00000448593_length(transcript)=1718nt_BP=405nt
GGCCGAACCTGGTTCCCGAGGCGCGGCGGCCGCGGCTGGGGGCGGGGAGGGGGGCGCAGGACCCCAAGTGGGGGTCCCGGAGCCAGAGGG
CCAATTCCTGTCCCCCCAGCAGCATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCGCTCGAGG
ACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAGGAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGC
CACCGCTGGAGGACATGGGACAACCCCCGGCGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATGGAGCCCG
AGCCCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAA
GGATAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGCTCCTGCAGGAGATGG
GTCACAGACCCGAGGGAAGATGTCTGAAGGTGGAAGGAAATCCAGCCTGCTCCAGAAAAGCAAAGATAGCAGTGGGGTCGGAAAGGGTGA
CCTGCAGTCCACGTTGCTGGAAGGGCATGGCACAGCTCCACCTGACCTGGATCTCTCTGCTATTAATGACAAAAGCATCGTCAAAAAGAC
GCCACAGTTAGCAAAAACAATATCAAAGAAACCTGAGTCAACATCATTTTCTGCCCCTCGGAAAAAGAGCCCGGATTTATCTGAAGCAAT
GGAAATGATGGAGTCTCAGACACTACTGCTGACGCTACTATCCGTAAAGATGGAGAACAATCTTGCTGAGTTTGAAAGAAGGGCAGAAAA
GAATTTATTAATAATGTGTAAGGAGAAGGAGAAGCTACAGAAAAAGGCCCACGAGCTGAAGCGCAGGCTTCTCCTCTCTCAGAGGAAGCG
GGAGCTGGCAGATGTCCTGGATGCCCAGATCGAGATGCTCAGCCCCTTCGAGGCAGTGGCCACACGCTTCAAGGAGCAATACAGGACATT
CGCCACGGCCCTGGACACTACCAGGCACGAGCTGCCCGTGAGGTCCATCCACCTGGAGGGAGATGGGCAGCAGCTCTTAGACGCCCTGCA
GCATGAACTGGTGACCACTCAGCGCCTCCTGGGAGAACTTGATGTTGGTGATTCGGAAGAAAATGTGCAGGTGCTGGACTTACTGAGCGA
ACTCAAGGACGTGACGGCGAAAAAGGACCTTGAGCTCCGAAGGAGCTTTGCCCAGGTGCTGGAACTCTCCGCAGAGGCAAGCAAAGAGGC
AGCCTTGGCAAACCAGGAAGTCTGGGAAGAGACCCAGGGCATGGCGCCCCCCAGCCGGTGGTATTTCAATCAAGACAGTGCCTGCAGAGA
ATCTGGGGGAGCACCCAAGAACACGCCCCTGTCTGAGGACGACAACCCGGGTGCCTCGTCAGCCCCCGCTCAGGCCACGTTCATCAGCCC
AAGCGAAGATTTTTCTTCAAGCAGCCAGGCAGAAGTCCCGCCCTCTCTCTCTCGTTCAGGGAGGGACTTGTCATGACTCATGGTTACATT
CAGGATACTTGAGCACTTTATATACTACCGTAGCACTGTAGCTATTTTTTATGTGATAATCTTGTTTGATAAAAAAGTAAACCTGTTTTG

>30528_30528_6_FKBP8-HAUS8_FKBP8_chr19_18652489_ENST00000610101_HAUS8_chr19_17184145_ENST00000448593_length(amino acids)=370AA_BP=
MQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKDSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPEST
SFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEMLS
PFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRR
SFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVPP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FKBP8-HAUS8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FKBP8-HAUS8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FKBP8-HAUS8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source