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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FLAD1-POLE (FusionGDB2 ID:30554)

Fusion Gene Summary for FLAD1-POLE

check button Fusion gene summary
Fusion gene informationFusion gene name: FLAD1-POLE
Fusion gene ID: 30554
HgeneTgene
Gene symbol

FLAD1

POLE

Gene ID

80308

5426

Gene nameflavin adenine dinucleotide synthetase 1DNA polymerase epsilon, catalytic subunit
SynonymsFAD1|FADS|LSMFLAD|PP591CRCS12|FILS|IMAGEI|POLE1
Cytomap

1q21.3

12q24.33

Type of geneprotein-codingprotein-coding
DescriptionFAD synthaseFAD pyrophosphorylaseFAD-synthetaseFMN adenylyltransferaseFad1, flavin adenine dinucleotide synthetase, homologDNA polymerase epsilon catalytic subunit ADNA polymerase II subunit ADNA polymerase epsilon catalytic subunit proteinpolymerase (DNA directed), epsilon, catalytic subunitpolymerase (DNA) epsilon, catalytic subunit
Modification date2020031320200313
UniProtAcc

Q8NFF5

.
Ensembl transtripts involved in fusion geneENST00000487371, ENST00000292180, 
ENST00000315144, ENST00000368432, 
ENST00000368433, ENST00000368431, 
ENST00000295530, ENST00000368428, 
ENST00000405236, 		ENST00000320574, 
ENST00000535270, ENST00000434528, 
Fusion gene scores* DoF score5 X 3 X 4=605 X 5 X 5=125
# samples 76
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLAD1 [Title/Abstract] AND POLE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFLAD1(154956542)-POLE(133236095), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLE

GO:0006287

base-excision repair, gap-filling

10559260


check buttonFusion gene breakpoints across FLAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POLE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01AFLAD1chr1

154956542

+POLEchr12

133236095

-


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Fusion Gene ORF analysis for FLAD1-POLE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000487371ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
3UTR-3CDSENST00000487371ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
3UTR-intronENST00000487371ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
5CDS-intronENST00000292180ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
5CDS-intronENST00000315144ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
5CDS-intronENST00000368432ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
5CDS-intronENST00000368433ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
5UTR-3CDSENST00000368431ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
5UTR-3CDSENST00000368431ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
5UTR-intronENST00000368431ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000292180ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000292180ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000315144ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000315144ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000368432ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000368432ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000368433ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
In-frameENST00000368433ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-3CDSENST00000295530ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-3CDSENST00000295530ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-3CDSENST00000368428ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-3CDSENST00000368428ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-3CDSENST00000405236ENST00000320574FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-3CDSENST00000405236ENST00000535270FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-intronENST00000295530ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-intronENST00000368428ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-
intron-intronENST00000405236ENST00000434528FLAD1chr1

154956542

+POLEchr12

133236095

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368433FLAD1chr1154956542+ENST00000320574POLEchr12133236095-545171534345151390
ENST00000368433FLAD1chr1154956542+ENST00000535270POLEchr12133236095-452371534345151390
ENST00000315144FLAD1chr1154956542+ENST00000320574POLEchr12133236095-50002646040641334
ENST00000315144FLAD1chr1154956542+ENST00000535270POLEchr12133236095-40722646040641334
ENST00000368432FLAD1chr1154956542+ENST00000320574POLEchr12133236095-49942585440581334
ENST00000368432FLAD1chr1154956542+ENST00000535270POLEchr12133236095-40662585440581334
ENST00000292180FLAD1chr1154956542+ENST00000320574POLEchr12133236095-543069432244941390
ENST00000292180FLAD1chr1154956542+ENST00000535270POLEchr12133236095-450269432244941390

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368433ENST00000320574FLAD1chr1154956542+POLEchr12133236095-0.0039951550.9960049
ENST00000368433ENST00000535270FLAD1chr1154956542+POLEchr12133236095-0.0056032730.9943967
ENST00000315144ENST00000320574FLAD1chr1154956542+POLEchr12133236095-0.0034714250.99652857
ENST00000315144ENST00000535270FLAD1chr1154956542+POLEchr12133236095-0.0051898550.9948101
ENST00000368432ENST00000320574FLAD1chr1154956542+POLEchr12133236095-0.0033785830.9966214
ENST00000368432ENST00000535270FLAD1chr1154956542+POLEchr12133236095-0.0050346470.9949654
ENST00000292180ENST00000320574FLAD1chr1154956542+POLEchr12133236095-0.0039041390.99609584
ENST00000292180ENST00000535270FLAD1chr1154956542+POLEchr12133236095-0.0054868650.99451315

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Fusion Genomic Features for FLAD1-POLE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FLAD1-POLE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154956542/chr12:133236095)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLAD1

Q8NFF5

.
FUNCTION: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:27259049}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOLEchr1:154956542chr12:133236095ENST0000032057424492221_223810202287.0MotifCysB motif
TgenePOLEchr1:154956542chr12:133236095ENST0000032057424492158_219010202287.0Zinc fingerCysA-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLAD1chr1:154956542chr12:133236095ENST00000292180+17114_205124588.0RegionNote=Molybdenum cofactor biosynthesis protein-like
HgeneFLAD1chr1:154956542chr12:133236095ENST00000292180+17398_555124588.0RegionNote=FAD synthase
HgeneFLAD1chr1:154956542chr12:133236095ENST00000315144+28114_20527491.0RegionNote=Molybdenum cofactor biosynthesis protein-like
HgeneFLAD1chr1:154956542chr12:133236095ENST00000315144+28398_55527491.0RegionNote=FAD synthase
HgeneFLAD1chr1:154956542chr12:133236095ENST00000368431+23114_2050295.0RegionNote=Molybdenum cofactor biosynthesis protein-like
HgeneFLAD1chr1:154956542chr12:133236095ENST00000368431+23398_5550295.0RegionNote=FAD synthase
HgeneFLAD1chr1:154956542chr12:133236095ENST00000368432+27114_20527447.0RegionNote=Molybdenum cofactor biosynthesis protein-like
HgeneFLAD1chr1:154956542chr12:133236095ENST00000368432+27398_55527447.0RegionNote=FAD synthase
HgeneFLAD1chr1:154956542chr12:133236095ENST00000405236+14114_2050135.66666666666666RegionNote=Molybdenum cofactor biosynthesis protein-like
HgeneFLAD1chr1:154956542chr12:133236095ENST00000405236+14398_5550135.66666666666666RegionNote=FAD synthase


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Fusion Gene Sequence for FLAD1-POLE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30554_30554_1_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000292180_POLE_chr12_133236095_ENST00000320574_length(transcript)=5430nt_BP=694nt
GCCGGTGAAGGGGCAGAACAGGCAGGTGAGAGTCTAAGAGGGCTCAGTAATCTGAAGCTTGGTGGGAAGAAGGGATTCTGGGCTAGAAAG
GGTGCAGAAGCCTGAAGTAGAAAGAGACGGGATTTTGGTCCGGGGTGGAGAGCGAATGCATTGAAAAGGGCCAAGGCCCAGGATAAGGTA
GACATTTAAAGGGGTACGGATGCCCAAGGTAGAGCAGACACTTGAGGAGACCAGCTCAGCAAACGGAAGACACTTAAAGTGGTAGGTTCT
CAAGAGAGAAGAAGTTTTTAAGACTAGAGCTAAGCAAGACATTTAAAAGGACATGGGTTGGGATTTGGGAACACGTTTATTCCAGAGGCA
GGAACAAAGGAGTCGCTTGTCAAGGATCTGGTTAGAGAAGACTAGGGTCTTCCTCGAAGGAAGCACGCGCACGCCTGCTCTCCCCCATTG
TCTTTTCTGGCTTCTCCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCCTGTAGACCTGGCAGGCCCCCC
GTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGGACCATGACATCTAGGGCCTC
TGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGCCAACATGCCTGACTCTGAGCT
ATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTACGTCCATCAGCACAGCAAAGCG
CCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCGCAAGCCCGAGGGCTCCCCTGT
CACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAAATGGCTCAAGAGCTCTTCCCT
TCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCAGAAGATCATCACCATCCCTGC
GGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCTGGAGAAGAATGATGTCTACAA
GCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGAAGACAGTCCGAGGCCAAGTGC
TCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAAGCGAGTTCTTTGGGAGAGCCA
GGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGGAACCAGCCAGGAGGAATGGCT
TGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAGGCAGCGTCTGGAGTCGGCAGA
GGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAACTGCCCGCAGCATCCTGGACCT
TCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGGCAGTGACTTGCACTGCATCAG
GCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCGCAAGGTAAATCGGGTCCTTCC
TCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAACGAGATCAACGCTGAGCTGTC
AGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGGCTGTGTGTGTGTGGTCAATAA
ACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTCTCTGGCCCAGTTCAGCTACCT
GGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGATCTTCATCCCCTCACAGCGCAG
GGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGCAGAGCACGGCCTCCTCCTGGA
GAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAAGACCATCTGCAGAGCCATCCA
GCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGAGCTGAAGAGGCTGGCCAGTGA
AATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCTGGACTGGCAGCGCCATGGAGC
CCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTACTTTCACATTCCCATTGGGAA
CCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCACCTGCTCTGGCTGTCCCCTAC
AGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGCCACTGTTGAGATCAACAGTTC
AGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTCTCACCATGTCAACGACATGGA
GGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGGTGGTCAGGCTGCCAGTGCCCC
GGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTGGGTGAAGGAGATCACCCAGTA
CCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCTTCATGACCCTGCCCTGCACCG
CACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATCAGTCATCTACGCCAACTTCAA
CCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAGCAGCATCCATTCAAAGGAGAC
CTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTATGGCGGAATCAAAGGAAAAGT
TTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAATGAGGACGATGAGGAGGAAAG
AGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACATTTTGCAGTTTTTGCCACAGGC
AGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAAGGACGGGCTGAGGCGCAGTGC
TCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGGAGCCCTTCCCGGAATGATCAC
CTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAAGAAAGTCACAGGCTCTCGGAA
CTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCTGGAGTTCATCAAATACGTGTG
CAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCTGGTGGATGTCGGCGAGTTCTC
CGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAACTTCTGCCGCGACCTGGACCT
GTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGCGCCCTACGACTCCTCTGCCAT
CGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCTGAAGTGCCGCGGGGTGAAGGA
GACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCATGGAACAGATCGGAATATTCCG
GAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCCACAGCTGGGCCATTAGCCAGC
CCCGGGCCCCGGGTGCCTCTGCGTCCGTGCCAGGCCTCCTGATGCCAAGGCCACATCCCCGTGCTTCCAGTGACCAGACCACTGACCACC
CTGACTGTCCAAACCTGTGACCCCAGGCCAGGGAACGGGGAGGAAACCAAAGAAAACCATTTTCAGGGAGCTCAGACGTCACAGGAGGGA
GCGGGAGCAGGATGTGGCCCTGGCCTCGCCAGAGCACCTGAAGAAGCAGGCCGTGAGCGAGGCTGCGAGTGCCCTGGGCGCCGTTTCTCA
CGCAGTGAATGCTTTTCCAGGCCTCTGTTGCTTCCTGCACCACACCTGGTGGGGTGGGAGCGTCCTCTAGGTGCCCCTAGTTCTTTGTCC
TGCCTCCCAGAGGGAGGAAAAGCCCCTGGGGGCTTCTGGCTCCCTGAGATTGGGCTCTGAGACGAGACGGGTTCCCAAGGCCCTGGTGGG
GCTGGAGTCTCACCTGTTTGCATGGAGAAATGGGCTGGCCCCACAGCCTCACAGGAGCAGTTTGTGGGCTGGTTTCCCCAGGAATCCAGA
CCCTAACCCGTGAGAATCTGGATTTTGGCTTGTGAGCCCTGCTTATTTGGAGCCGGGTCTAGAGGGAACCCTCTATCAGCCTCAGGAAAA
CAAGACCTCTGTGCACCTCACTTTTGGCTCACTGCAGCCCTTGTCCTTCACCTCCACACAGGACCAGCTGGAAGCAGAAAGAAGAAAGGC
CAATTTCACAGGGCACCAAACAAGTATGAAATGTAAATCAGAAATGCAGACACCCCAGACGAGAGCCTCACAGGAGGGAGGGGGCCCCAC
AGGCTCCCCAGGAGGCTCGTGTCTTTGGCCCAGAGCCAGCCTTAGTTTGTCCCTGCCATCTACTGTCTGAGGCCATCGCTGCTACACTTT

>30554_30554_1_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000292180_POLE_chr12_133236095_ENST00000320574_length(amino acids)=1390AA_BP=122
MGWDLGTRLFQRQEQRSRLSRIWLEKTRVFLEGSTRTPALPHCLFWLLQVPSTQDPLFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQ
RGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSC
RYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDW
LHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILG
QPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFR
LWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFR
ALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSL
GALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADK
INYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVM
EFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILK
SMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAY
VEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLL
ENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTI
TQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEV
ICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTI

--------------------------------------------------------------
>30554_30554_2_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000292180_POLE_chr12_133236095_ENST00000535270_length(transcript)=4502nt_BP=694nt
GCCGGTGAAGGGGCAGAACAGGCAGGTGAGAGTCTAAGAGGGCTCAGTAATCTGAAGCTTGGTGGGAAGAAGGGATTCTGGGCTAGAAAG
GGTGCAGAAGCCTGAAGTAGAAAGAGACGGGATTTTGGTCCGGGGTGGAGAGCGAATGCATTGAAAAGGGCCAAGGCCCAGGATAAGGTA
GACATTTAAAGGGGTACGGATGCCCAAGGTAGAGCAGACACTTGAGGAGACCAGCTCAGCAAACGGAAGACACTTAAAGTGGTAGGTTCT
CAAGAGAGAAGAAGTTTTTAAGACTAGAGCTAAGCAAGACATTTAAAAGGACATGGGTTGGGATTTGGGAACACGTTTATTCCAGAGGCA
GGAACAAAGGAGTCGCTTGTCAAGGATCTGGTTAGAGAAGACTAGGGTCTTCCTCGAAGGAAGCACGCGCACGCCTGCTCTCCCCCATTG
TCTTTTCTGGCTTCTCCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCCTGTAGACCTGGCAGGCCCCCC
GTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGGACCATGACATCTAGGGCCTC
TGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGCCAACATGCCTGACTCTGAGCT
ATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTACGTCCATCAGCACAGCAAAGCG
CCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCGCAAGCCCGAGGGCTCCCCTGT
CACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAAATGGCTCAAGAGCTCTTCCCT
TCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCAGAAGATCATCACCATCCCTGC
GGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCTGGAGAAGAATGATGTCTACAA
GCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGAAGACAGTCCGAGGCCAAGTGC
TCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAAGCGAGTTCTTTGGGAGAGCCA
GGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGGAACCAGCCAGGAGGAATGGCT
TGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAGGCAGCGTCTGGAGTCGGCAGA
GGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAACTGCCCGCAGCATCCTGGACCT
TCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGGCAGTGACTTGCACTGCATCAG
GCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCGCAAGGTAAATCGGGTCCTTCC
TCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAACGAGATCAACGCTGAGCTGTC
AGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGGCTGTGTGTGTGTGGTCAATAA
ACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTCTCTGGCCCAGTTCAGCTACCT
GGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGATCTTCATCCCCTCACAGCGCAG
GGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGCAGAGCACGGCCTCCTCCTGGA
GAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAAGACCATCTGCAGAGCCATCCA
GCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGAGCTGAAGAGGCTGGCCAGTGA
AATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCTGGACTGGCAGCGCCATGGAGC
CCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTACTTTCACATTCCCATTGGGAA
CCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCACCTGCTCTGGCTGTCCCCTAC
AGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGCCACTGTTGAGATCAACAGTTC
AGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTCTCACCATGTCAACGACATGGA
GGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGGTGGTCAGGCTGCCAGTGCCCC
GGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTGGGTGAAGGAGATCACCCAGTA
CCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCTTCATGACCCTGCCCTGCACCG
CACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATCAGTCATCTACGCCAACTTCAA
CCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAGCAGCATCCATTCAAAGGAGAC
CTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTATGGCGGAATCAAAGGAAAAGT
TTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAATGAGGACGATGAGGAGGAAAG
AGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACATTTTGCAGTTTTTGCCACAGGC
AGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAAGGACGGGCTGAGGCGCAGTGC
TCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGGAGCCCTTCCCGGAATGATCAC
CTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAAGAAAGTCACAGGCTCTCGGAA
CTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCTGGAGTTCATCAAATACGTGTG
CAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCTGGTGGATGTCGGCGAGTTCTC
CGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAACTTCTGCCGCGACCTGGACCT
GTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGCGCCCTACGACTCCTCTGCCAT
CGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCTGAAGTGCCGCGGGGTGAAGGA
GACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCATGGAACAGATCGGAATATTCCG
GAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCCACAGCTGGGCCATTAGCCAGC

>30554_30554_2_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000292180_POLE_chr12_133236095_ENST00000535270_length(amino acids)=1390AA_BP=122
MGWDLGTRLFQRQEQRSRLSRIWLEKTRVFLEGSTRTPALPHCLFWLLQVPSTQDPLFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQ
RGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSC
RYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDW
LHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILG
QPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFR
LWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFR
ALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSL
GALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADK
INYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVM
EFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILK
SMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAY
VEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLL
ENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTI
TQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEV
ICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTI

--------------------------------------------------------------
>30554_30554_3_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000315144_POLE_chr12_133236095_ENST00000320574_length(transcript)=5000nt_BP=264nt
GAACAAGGGAAAGAGCCGGTGAAGGGGCAGAACAGGCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCCT
GTAGACCTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGG
ACCATGACATCTAGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGCC
AACATGCCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTACG
TCCATCAGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCGC
AAGCCCGAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAAA
TGGCTCAAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCAG
AAGATCATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCTG
GAGAAGAATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGAA
GACAGTCCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAAG
CGAGTTCTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGGA
ACCAGCCAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAGG
CAGCGTCTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAACT
GCCCGCAGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGGC
AGTGACTTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCGC
AAGGTAAATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAAC
GAGATCAACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGGC
TGTGTGTGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTCT
CTGGCCCAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGATC
TTCATCCCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGCA
GAGCACGGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAAG
ACCATCTGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGAG
CTGAAGAGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCTG
GACTGGCAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTAC
TTTCACATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCAC
CTGCTCTGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGCC
ACTGTTGAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTCT
CACCATGTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGGT
GGTCAGGCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTGG
GTGAAGGAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCTT
CATGACCCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATCA
GTCATCTACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAGC
AGCATCCATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTAT
GGCGGAATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAAT
GAGGACGATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACATT
TTGCAGTTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAAG
GACGGGCTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGGA
GCCCTTCCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAAG
AAAGTCACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCTG
GAGTTCATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCTG
GTGGATGTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAAC
TTCTGCCGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGCG
CCCTACGACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCTG
AAGTGCCGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCATG
GAACAGATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCCA
CAGCTGGGCCATTAGCCAGCCCCGGGCCCCGGGTGCCTCTGCGTCCGTGCCAGGCCTCCTGATGCCAAGGCCACATCCCCGTGCTTCCAG
TGACCAGACCACTGACCACCCTGACTGTCCAAACCTGTGACCCCAGGCCAGGGAACGGGGAGGAAACCAAAGAAAACCATTTTCAGGGAG
CTCAGACGTCACAGGAGGGAGCGGGAGCAGGATGTGGCCCTGGCCTCGCCAGAGCACCTGAAGAAGCAGGCCGTGAGCGAGGCTGCGAGT
GCCCTGGGCGCCGTTTCTCACGCAGTGAATGCTTTTCCAGGCCTCTGTTGCTTCCTGCACCACACCTGGTGGGGTGGGAGCGTCCTCTAG
GTGCCCCTAGTTCTTTGTCCTGCCTCCCAGAGGGAGGAAAAGCCCCTGGGGGCTTCTGGCTCCCTGAGATTGGGCTCTGAGACGAGACGG
GTTCCCAAGGCCCTGGTGGGGCTGGAGTCTCACCTGTTTGCATGGAGAAATGGGCTGGCCCCACAGCCTCACAGGAGCAGTTTGTGGGCT
GGTTTCCCCAGGAATCCAGACCCTAACCCGTGAGAATCTGGATTTTGGCTTGTGAGCCCTGCTTATTTGGAGCCGGGTCTAGAGGGAACC
CTCTATCAGCCTCAGGAAAACAAGACCTCTGTGCACCTCACTTTTGGCTCACTGCAGCCCTTGTCCTTCACCTCCACACAGGACCAGCTG
GAAGCAGAAAGAAGAAAGGCCAATTTCACAGGGCACCAAACAAGTATGAAATGTAAATCAGAAATGCAGACACCCCAGACGAGAGCCTCA
CAGGAGGGAGGGGGCCCCACAGGCTCCCCAGGAGGCTCGTGTCTTTGGCCCAGAGCCAGCCTTAGTTTGTCCCTGCCATCTACTGTCTGA

>30554_30554_3_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000315144_POLE_chr12_133236095_ENST00000320574_length(amino acids)=1334AA_BP=66
MFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQRGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRK
LEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDY
YIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPH
PAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPA
TGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSV
PEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHH
AQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGP
TLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLF
FARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQ
QASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQL
IAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQK
AGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQ
LSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQV
NKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLM

--------------------------------------------------------------
>30554_30554_4_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000315144_POLE_chr12_133236095_ENST00000535270_length(transcript)=4072nt_BP=264nt
GAACAAGGGAAAGAGCCGGTGAAGGGGCAGAACAGGCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCCT
GTAGACCTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGG
ACCATGACATCTAGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGCC
AACATGCCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTACG
TCCATCAGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCGC
AAGCCCGAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAAA
TGGCTCAAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCAG
AAGATCATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCTG
GAGAAGAATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGAA
GACAGTCCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAAG
CGAGTTCTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGGA
ACCAGCCAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAGG
CAGCGTCTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAACT
GCCCGCAGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGGC
AGTGACTTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCGC
AAGGTAAATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAAC
GAGATCAACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGGC
TGTGTGTGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTCT
CTGGCCCAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGATC
TTCATCCCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGCA
GAGCACGGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAAG
ACCATCTGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGAG
CTGAAGAGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCTG
GACTGGCAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTAC
TTTCACATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCAC
CTGCTCTGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGCC
ACTGTTGAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTCT
CACCATGTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGGT
GGTCAGGCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTGG
GTGAAGGAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCTT
CATGACCCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATCA
GTCATCTACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAGC
AGCATCCATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTAT
GGCGGAATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAAT
GAGGACGATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACATT
TTGCAGTTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAAG
GACGGGCTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGGA
GCCCTTCCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAAG
AAAGTCACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCTG
GAGTTCATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCTG
GTGGATGTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAAC
TTCTGCCGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGCG
CCCTACGACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCTG
AAGTGCCGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCATG
GAACAGATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCCA

>30554_30554_4_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000315144_POLE_chr12_133236095_ENST00000535270_length(amino acids)=1334AA_BP=66
MFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQRGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRK
LEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDY
YIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPH
PAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPA
TGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSV
PEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHH
AQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGP
TLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLF
FARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQ
QASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQL
IAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQK
AGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQ
LSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQV
NKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLM

--------------------------------------------------------------
>30554_30554_5_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368432_POLE_chr12_133236095_ENST00000320574_length(transcript)=4994nt_BP=258nt
GGGAAAGAGCCGGTGAAGGGGCAGAACAGGCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCCTGTAGAC
CTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGGACCATG
ACATCTAGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGCCAACATG
CCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTACGTCCATC
AGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCGCAAGCCC
GAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAAATGGCTC
AAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCAGAAGATC
ATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCTGGAGAAG
AATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGAAGACAGT
CCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAAGCGAGTT
CTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGGAACCAGC
CAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAGGCAGCGT
CTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAACTGCCCGC
AGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGGCAGTGAC
TTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCGCAAGGTA
AATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAACGAGATC
AACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGGCTGTGTG
TGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTCTCTGGCC
CAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGATCTTCATC
CCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGCAGAGCAC
GGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAAGACCATC
TGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGAGCTGAAG
AGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCTGGACTGG
CAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTACTTTCAC
ATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCACCTGCTC
TGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGCCACTGTT
GAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTCTCACCAT
GTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGGTGGTCAG
GCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTGGGTGAAG
GAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCTTCATGAC
CCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATCAGTCATC
TACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAGCAGCATC
CATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTATGGCGGA
ATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAATGAGGAC
GATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACATTTTGCAG
TTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAAGGACGGG
CTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGGAGCCCTT
CCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAAGAAAGTC
ACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCTGGAGTTC
ATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCTGGTGGAT
GTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAACTTCTGC
CGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGCGCCCTAC
GACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCTGAAGTGC
CGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCATGGAACAG
ATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCCACAGCTG
GGCCATTAGCCAGCCCCGGGCCCCGGGTGCCTCTGCGTCCGTGCCAGGCCTCCTGATGCCAAGGCCACATCCCCGTGCTTCCAGTGACCA
GACCACTGACCACCCTGACTGTCCAAACCTGTGACCCCAGGCCAGGGAACGGGGAGGAAACCAAAGAAAACCATTTTCAGGGAGCTCAGA
CGTCACAGGAGGGAGCGGGAGCAGGATGTGGCCCTGGCCTCGCCAGAGCACCTGAAGAAGCAGGCCGTGAGCGAGGCTGCGAGTGCCCTG
GGCGCCGTTTCTCACGCAGTGAATGCTTTTCCAGGCCTCTGTTGCTTCCTGCACCACACCTGGTGGGGTGGGAGCGTCCTCTAGGTGCCC
CTAGTTCTTTGTCCTGCCTCCCAGAGGGAGGAAAAGCCCCTGGGGGCTTCTGGCTCCCTGAGATTGGGCTCTGAGACGAGACGGGTTCCC
AAGGCCCTGGTGGGGCTGGAGTCTCACCTGTTTGCATGGAGAAATGGGCTGGCCCCACAGCCTCACAGGAGCAGTTTGTGGGCTGGTTTC
CCCAGGAATCCAGACCCTAACCCGTGAGAATCTGGATTTTGGCTTGTGAGCCCTGCTTATTTGGAGCCGGGTCTAGAGGGAACCCTCTAT
CAGCCTCAGGAAAACAAGACCTCTGTGCACCTCACTTTTGGCTCACTGCAGCCCTTGTCCTTCACCTCCACACAGGACCAGCTGGAAGCA
GAAAGAAGAAAGGCCAATTTCACAGGGCACCAAACAAGTATGAAATGTAAATCAGAAATGCAGACACCCCAGACGAGAGCCTCACAGGAG
GGAGGGGGCCCCACAGGCTCCCCAGGAGGCTCGTGTCTTTGGCCCAGAGCCAGCCTTAGTTTGTCCCTGCCATCTACTGTCTGAGGCCAT

>30554_30554_5_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368432_POLE_chr12_133236095_ENST00000320574_length(amino acids)=1334AA_BP=66
MFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQRGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRK
LEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDY
YIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPH
PAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPA
TGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSV
PEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHH
AQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGP
TLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLF
FARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQ
QASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQL
IAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQK
AGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQ
LSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQV
NKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLM

--------------------------------------------------------------
>30554_30554_6_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368432_POLE_chr12_133236095_ENST00000535270_length(transcript)=4066nt_BP=258nt
GGGAAAGAGCCGGTGAAGGGGCAGAACAGGCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCCTGTAGAC
CTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGGACCATG
ACATCTAGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGCCAACATG
CCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTACGTCCATC
AGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCGCAAGCCC
GAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAAATGGCTC
AAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCAGAAGATC
ATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCTGGAGAAG
AATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGAAGACAGT
CCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAAGCGAGTT
CTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGGAACCAGC
CAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAGGCAGCGT
CTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAACTGCCCGC
AGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGGCAGTGAC
TTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCGCAAGGTA
AATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAACGAGATC
AACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGGCTGTGTG
TGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTCTCTGGCC
CAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGATCTTCATC
CCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGCAGAGCAC
GGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAAGACCATC
TGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGAGCTGAAG
AGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCTGGACTGG
CAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTACTTTCAC
ATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCACCTGCTC
TGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGCCACTGTT
GAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTCTCACCAT
GTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGGTGGTCAG
GCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTGGGTGAAG
GAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCTTCATGAC
CCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATCAGTCATC
TACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAGCAGCATC
CATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTATGGCGGA
ATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAATGAGGAC
GATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACATTTTGCAG
TTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAAGGACGGG
CTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGGAGCCCTT
CCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAAGAAAGTC
ACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCTGGAGTTC
ATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCTGGTGGAT
GTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAACTTCTGC
CGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGCGCCCTAC
GACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCTGAAGTGC
CGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCATGGAACAG
ATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCCACAGCTG

>30554_30554_6_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368432_POLE_chr12_133236095_ENST00000535270_length(amino acids)=1334AA_BP=66
MFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQRGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRK
LEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDY
YIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPH
PAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPA
TGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSV
PEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHH
AQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGP
TLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLF
FARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQ
QASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQL
IAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQK
AGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQ
LSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQV
NKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLM

--------------------------------------------------------------
>30554_30554_7_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368433_POLE_chr12_133236095_ENST00000320574_length(transcript)=5451nt_BP=715nt
AGGAAAGGAACAAGGGAAAGAGCCGGTGAAGGGGCAGAACAGGCAGGTGAGAGTCTAAGAGGGCTCAGTAATCTGAAGCTTGGTGGGAAG
AAGGGATTCTGGGCTAGAAAGGGTGCAGAAGCCTGAAGTAGAAAGAGACGGGATTTTGGTCCGGGGTGGAGAGCGAATGCATTGAAAAGG
GCCAAGGCCCAGGATAAGGTAGACATTTAAAGGGGTACGGATGCCCAAGGTAGAGCAGACACTTGAGGAGACCAGCTCAGCAAACGGAAG
ACACTTAAAGTGGTAGGTTCTCAAGAGAGAAGAAGTTTTTAAGACTAGAGCTAAGCAAGACATTTAAAAGGACATGGGTTGGGATTTGGG
AACACGTTTATTCCAGAGGCAGGAACAAAGGAGTCGCTTGTCAAGGATCTGGTTAGAGAAGACTAGGGTCTTCCTCGAAGGAAGCACGCG
CACGCCTGCTCTCCCCCATTGTCTTTTCTGGCTTCTCCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCC
TGTAGACCTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAG
GACCATGACATCTAGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGC
CAACATGCCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTAC
GTCCATCAGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCG
CAAGCCCGAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAA
ATGGCTCAAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCA
GAAGATCATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCT
GGAGAAGAATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGA
AGACAGTCCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAA
GCGAGTTCTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGG
AACCAGCCAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAG
GCAGCGTCTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAAC
TGCCCGCAGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGG
CAGTGACTTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCG
CAAGGTAAATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAA
CGAGATCAACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGG
CTGTGTGTGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTC
TCTGGCCCAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGAT
CTTCATCCCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGC
AGAGCACGGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAA
GACCATCTGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGA
GCTGAAGAGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCT
GGACTGGCAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTA
CTTTCACATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCA
CCTGCTCTGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGC
CACTGTTGAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTC
TCACCATGTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGG
TGGTCAGGCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTG
GGTGAAGGAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCT
TCATGACCCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATC
AGTCATCTACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAG
CAGCATCCATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTA
TGGCGGAATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAA
TGAGGACGATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACAT
TTTGCAGTTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAA
GGACGGGCTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGG
AGCCCTTCCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAA
GAAAGTCACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCT
GGAGTTCATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCT
GGTGGATGTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAA
CTTCTGCCGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGC
GCCCTACGACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCT
GAAGTGCCGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCAT
GGAACAGATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCC
ACAGCTGGGCCATTAGCCAGCCCCGGGCCCCGGGTGCCTCTGCGTCCGTGCCAGGCCTCCTGATGCCAAGGCCACATCCCCGTGCTTCCA
GTGACCAGACCACTGACCACCCTGACTGTCCAAACCTGTGACCCCAGGCCAGGGAACGGGGAGGAAACCAAAGAAAACCATTTTCAGGGA
GCTCAGACGTCACAGGAGGGAGCGGGAGCAGGATGTGGCCCTGGCCTCGCCAGAGCACCTGAAGAAGCAGGCCGTGAGCGAGGCTGCGAG
TGCCCTGGGCGCCGTTTCTCACGCAGTGAATGCTTTTCCAGGCCTCTGTTGCTTCCTGCACCACACCTGGTGGGGTGGGAGCGTCCTCTA
GGTGCCCCTAGTTCTTTGTCCTGCCTCCCAGAGGGAGGAAAAGCCCCTGGGGGCTTCTGGCTCCCTGAGATTGGGCTCTGAGACGAGACG
GGTTCCCAAGGCCCTGGTGGGGCTGGAGTCTCACCTGTTTGCATGGAGAAATGGGCTGGCCCCACAGCCTCACAGGAGCAGTTTGTGGGC
TGGTTTCCCCAGGAATCCAGACCCTAACCCGTGAGAATCTGGATTTTGGCTTGTGAGCCCTGCTTATTTGGAGCCGGGTCTAGAGGGAAC
CCTCTATCAGCCTCAGGAAAACAAGACCTCTGTGCACCTCACTTTTGGCTCACTGCAGCCCTTGTCCTTCACCTCCACACAGGACCAGCT
GGAAGCAGAAAGAAGAAAGGCCAATTTCACAGGGCACCAAACAAGTATGAAATGTAAATCAGAAATGCAGACACCCCAGACGAGAGCCTC
ACAGGAGGGAGGGGGCCCCACAGGCTCCCCAGGAGGCTCGTGTCTTTGGCCCAGAGCCAGCCTTAGTTTGTCCCTGCCATCTACTGTCTG

>30554_30554_7_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368433_POLE_chr12_133236095_ENST00000320574_length(amino acids)=1390AA_BP=122
MGWDLGTRLFQRQEQRSRLSRIWLEKTRVFLEGSTRTPALPHCLFWLLQVPSTQDPLFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQ
RGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSC
RYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDW
LHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILG
QPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFR
LWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFR
ALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSL
GALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADK
INYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVM
EFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILK
SMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAY
VEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLL
ENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTI
TQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEV
ICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTI

--------------------------------------------------------------
>30554_30554_8_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368433_POLE_chr12_133236095_ENST00000535270_length(transcript)=4523nt_BP=715nt
AGGAAAGGAACAAGGGAAAGAGCCGGTGAAGGGGCAGAACAGGCAGGTGAGAGTCTAAGAGGGCTCAGTAATCTGAAGCTTGGTGGGAAG
AAGGGATTCTGGGCTAGAAAGGGTGCAGAAGCCTGAAGTAGAAAGAGACGGGATTTTGGTCCGGGGTGGAGAGCGAATGCATTGAAAAGG
GCCAAGGCCCAGGATAAGGTAGACATTTAAAGGGGTACGGATGCCCAAGGTAGAGCAGACACTTGAGGAGACCAGCTCAGCAAACGGAAG
ACACTTAAAGTGGTAGGTTCTCAAGAGAGAAGAAGTTTTTAAGACTAGAGCTAAGCAAGACATTTAAAAGGACATGGGTTGGGATTTGGG
AACACGTTTATTCCAGAGGCAGGAACAAAGGAGTCGCTTGTCAAGGATCTGGTTAGAGAAGACTAGGGTCTTCCTCGAAGGAAGCACGCG
CACGCCTGCTCTCCCCCATTGTCTTTTCTGGCTTCTCCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGCTATGGCCCCCAGTGCCC
TGTAGACCTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGGGGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAG
GACCATGACATCTAGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGATGAGATCCTTAAGGCAGC
CAACATGCCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTAC
GTCCATCAGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCG
CAAGCCCGAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAA
ATGGCTCAAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTACATTGAGCGGCTGGGAAGCGCCATCCA
GAAGATCATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACACCCCGACTGGCTGCACAAAAAACTGCT
GGAGAAGAATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGA
AGACAGTCCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAA
GCGAGTTCTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGG
AACCAGCCAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAG
GCAGCGTCTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAAC
TGCCCGCAGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGG
CAGTGACTTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCG
CAAGGTAAATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCCAGAGGACATGTACCAGGAACACATCAA
CGAGATCAACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGG
CTGTGTGTGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTC
TCTGGCCCAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGCACAGGCCCACAAAGCGCTCTTCGGGAT
CTTCATCCCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGC
AGAGCACGGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAA
GACCATCTGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGA
GCTGAAGAGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGTGGCTGACAAGATCAACTATGGGGTCCT
GGACTGGCAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTA
CTTTCACATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCA
CCTGCTCTGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTGTCTTGTCATGGAGTTCGATGACCAAGC
CACTGTTGAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTC
TCACCATGTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCAGGCCTCCCTGGAGGACATGATCACGGG
TGGTCAGGCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTG
GGTGAAGGAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCT
TCATGACCCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATC
AGTCATCTACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGCCATCGCTTACGTGGAGTACATCACCAG
CAGCATCCATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATTTCTTCTCTGGATGGATCCATCTAACTA
TGGCGGAATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAA
TGAGGACGATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGAGGATTTACTGGAAAACAACTGGAACAT
TTTGCAGTTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTACATCGTGGCCGTGTACCACTGCATGAA
GGACGGGCTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGG
AGCCCTTCCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAA
GAAAGTCACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCT
GGAGTTCATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCT
GGTGGATGTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAA
CTTCTGCCGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGC
GCCCTACGACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCT
GAAGTGCCGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGCCCTCACCATCCACACCCAGGTCTTCAT
GGAACAGATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGACCCTGGAGTGGCTGCTGCAGAAGAACCC

>30554_30554_8_FLAD1-POLE_FLAD1_chr1_154956542_ENST00000368433_POLE_chr12_133236095_ENST00000535270_length(amino acids)=1390AA_BP=122
MGWDLGTRLFQRQEQRSRLSRIWLEKTRVFLEGSTRTPALPHCLFWLLQVPSTQDPLFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQ
RGREGRTMTSRASELSPGRSVTAGIIIVGDEILKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSC
RYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDW
LHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILG
QPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFR
LWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFR
ALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSL
GALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADK
INYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVM
EFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILK
SMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAY
VEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLL
ENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTI
TQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEV
ICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FLAD1-POLE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FLAD1-POLE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FLAD1-POLE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource