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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FLNA-ACTG2 (FusionGDB2 ID:30627)

Fusion Gene Summary for FLNA-ACTG2

check button Fusion gene summary
Fusion gene informationFusion gene name: FLNA-ACTG2
Fusion gene ID: 30627
HgeneTgene
Gene symbol

FLNA

ACTG2

Gene ID

2316

72

Gene namefilamin Aactin gamma 2, smooth muscle
SynonymsABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVDACT|ACTA3|ACTE|ACTL3|ACTSG|VSCM
Cytomap

Xq28

2p13.1

Type of geneprotein-codingprotein-coding
Descriptionfilamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filaminactin, gamma-enteric smooth muscleactin, gamma 2, smooth muscle, entericactin-like proteinalpha-actin-3
Modification date2020031320200313
UniProtAcc

P21333

P63267

Ensembl transtripts involved in fusion geneENST00000344736, ENST00000360319, 
ENST00000369850, ENST00000422373, 
ENST00000369856, ENST00000498491, 
ENST00000409624, ENST00000409918, 
ENST00000345517, ENST00000409731, 
Fusion gene scores* DoF score24 X 29 X 9=626412 X 15 X 8=1440
# samples 3420
** MAII scorelog2(34/6264*10)=-4.20347756115334
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLNA [Title/Abstract] AND ACTG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTG2(74146651)-FLNA(153590628), # samples:1
FLNA(153595765)-ACTG2(74140612), # samples:1
Anticipated loss of major functional domain due to fusion event.ACTG2-FLNA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ACTG2-FLNA seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ACTG2-FLNA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ACTG2-FLNA seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFLNA

GO:0016479

negative regulation of transcription by RNA polymerase I

22307607

HgeneFLNA

GO:0030334

regulation of cell migration

16291724

HgeneFLNA

GO:0031532

actin cytoskeleton reorganization

10051605

HgeneFLNA

GO:0034394

protein localization to cell surface

18322202

HgeneFLNA

GO:0043113

receptor clustering

10692483

HgeneFLNA

GO:0043433

negative regulation of DNA-binding transcription factor activity

15684392

HgeneFLNA

GO:0044319

wound healing, spreading of cells

16291724

HgeneFLNA

GO:0045184

establishment of protein localization

18322202

HgeneFLNA

GO:0051764

actin crosslink formation

10051605

HgeneFLNA

GO:0072659

protein localization to plasma membrane

24951510

HgeneFLNA

GO:0090307

mitotic spindle assembly

18548008

HgeneFLNA

GO:1901381

positive regulation of potassium ion transmembrane transport

24951510


check buttonFusion gene breakpoints across FLNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACTG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-H9-A6BX-01AFLNAchrX

153595765

-ACTG2chr2

74140612

+


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Fusion Gene ORF analysis for FLNA-ACTG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344736ENST00000409624FLNAchrX

153595765

-ACTG2chr2

74140612

+
5CDS-intronENST00000344736ENST00000409918FLNAchrX

153595765

-ACTG2chr2

74140612

+
5CDS-intronENST00000360319ENST00000409624FLNAchrX

153595765

-ACTG2chr2

74140612

+
5CDS-intronENST00000360319ENST00000409918FLNAchrX

153595765

-ACTG2chr2

74140612

+
5CDS-intronENST00000369850ENST00000409624FLNAchrX

153595765

-ACTG2chr2

74140612

+
5CDS-intronENST00000369850ENST00000409918FLNAchrX

153595765

-ACTG2chr2

74140612

+
5CDS-intronENST00000422373ENST00000409624FLNAchrX

153595765

-ACTG2chr2

74140612

+
5CDS-intronENST00000422373ENST00000409918FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000344736ENST00000345517FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000344736ENST00000409731FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000360319ENST00000345517FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000360319ENST00000409731FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000369850ENST00000345517FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000369850ENST00000409731FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000422373ENST00000345517FLNAchrX

153595765

-ACTG2chr2

74140612

+
In-frameENST00000422373ENST00000409731FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-3CDSENST00000369856ENST00000345517FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-3CDSENST00000369856ENST00000409731FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-3CDSENST00000498491ENST00000345517FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-3CDSENST00000498491ENST00000409731FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-intronENST00000369856ENST00000409624FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-intronENST00000369856ENST00000409918FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-intronENST00000498491ENST00000409624FLNAchrX

153595765

-ACTG2chr2

74140612

+
intron-intronENST00000498491ENST00000409918FLNAchrX

153595765

-ACTG2chr2

74140612

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360319FLNAchrX153595765-ENST00000409731ACTG2chr274140612+187690621585527
ENST00000360319FLNAchrX153595765-ENST00000345517ACTG2chr274140612+187690621585527
ENST00000422373FLNAchrX153595765-ENST00000409731ACTG2chr274140612+208711172131796527
ENST00000422373FLNAchrX153595765-ENST00000345517ACTG2chr274140612+208711172131796527
ENST00000369850FLNAchrX153595765-ENST00000409731ACTG2chr274140612+207511052011784527
ENST00000369850FLNAchrX153595765-ENST00000345517ACTG2chr274140612+207511052011784527
ENST00000344736FLNAchrX153595765-ENST00000409731ACTG2chr274140612+188191171590527
ENST00000344736FLNAchrX153595765-ENST00000345517ACTG2chr274140612+188191171590527

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360319ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.0143639020.9856361
ENST00000360319ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.0143639020.9856361
ENST00000422373ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.0162905850.98370945
ENST00000422373ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.0162905850.98370945
ENST00000369850ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.016160690.9838394
ENST00000369850ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.016160690.9838394
ENST00000344736ENST00000409731FLNAchrX153595765-ACTG2chr274140612+0.0144328150.9855672
ENST00000344736ENST00000345517FLNAchrX153595765-ACTG2chr274140612+0.0144328150.9855672

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Fusion Genomic Features for FLNA-ACTG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FLNAchrX153595764-ACTG2chr274140611+0.0010368990.9989631
FLNAchrX153595764-ACTG2chr274140611+0.0010368990.9989631

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FLNA-ACTG2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:74146651/chr2:153590628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLNA

P21333

ACTG2

P63267

FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446166_2692892640.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-44643_1492892640.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548166_2692892648.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-54843_1492892648.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547166_2692892640.0DomainCalponin-homology (CH) 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-54743_1492892640.0DomainCalponin-homology (CH) 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462_2742892640.0RegionNote=Actin-binding
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482_2742892648.0RegionNote=Actin-binding
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472_2742892640.0RegionNote=Actin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461741_17782892640.0RegionNote=Hinge 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462517_25512892640.0RegionNote=Hinge 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462517_26472892640.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481741_17782892648.0RegionNote=Hinge 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482517_25512892648.0RegionNote=Hinge 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482517_26472892648.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471741_17782892640.0RegionNote=Hinge 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472517_25512892640.0RegionNote=Hinge 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472517_26472892640.0RegionNote=Self-association site%2C tail
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461062_11542892640.0RepeatNote=Filamin 9
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461155_12492892640.0RepeatNote=Filamin 10
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461250_13492892640.0RepeatNote=Filamin 11
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461350_14422892640.0RepeatNote=Filamin 12
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461443_15392892640.0RepeatNote=Filamin 13
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461540_16362892640.0RepeatNote=Filamin 14
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461649_17402892640.0RepeatNote=Filamin 15
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461779_18602892640.0RepeatNote=Filamin 16
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461861_19502892640.0RepeatNote=Filamin 17
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461951_20392892640.0RepeatNote=Filamin 18
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462042_21312892640.0RepeatNote=Filamin 19
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462132_22302892640.0RepeatNote=Filamin 20
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462233_23252892640.0RepeatNote=Filamin 21
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462327_24202892640.0RepeatNote=Filamin 22
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462424_25162892640.0RepeatNote=Filamin 23
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4462552_26462892640.0RepeatNote=Filamin 24
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446276_3742892640.0RepeatNote=Filamin 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446376_4742892640.0RepeatNote=Filamin 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446475_5702892640.0RepeatNote=Filamin 3
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446571_6632892640.0RepeatNote=Filamin 4
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446667_7632892640.0RepeatNote=Filamin 5
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446764_8662892640.0RepeatNote=Filamin 6
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446867_9652892640.0RepeatNote=Filamin 7
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-446966_10612892640.0RepeatNote=Filamin 8
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481062_11542892648.0RepeatNote=Filamin 9
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481155_12492892648.0RepeatNote=Filamin 10
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481250_13492892648.0RepeatNote=Filamin 11
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481350_14422892648.0RepeatNote=Filamin 12
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481443_15392892648.0RepeatNote=Filamin 13
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481540_16362892648.0RepeatNote=Filamin 14
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481649_17402892648.0RepeatNote=Filamin 15
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481779_18602892648.0RepeatNote=Filamin 16
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481861_19502892648.0RepeatNote=Filamin 17
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481951_20392892648.0RepeatNote=Filamin 18
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482042_21312892648.0RepeatNote=Filamin 19
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482132_22302892648.0RepeatNote=Filamin 20
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482233_23252892648.0RepeatNote=Filamin 21
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482327_24202892648.0RepeatNote=Filamin 22
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482424_25162892648.0RepeatNote=Filamin 23
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5482552_26462892648.0RepeatNote=Filamin 24
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548276_3742892648.0RepeatNote=Filamin 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548376_4742892648.0RepeatNote=Filamin 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548475_5702892648.0RepeatNote=Filamin 3
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548571_6632892648.0RepeatNote=Filamin 4
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548667_7632892648.0RepeatNote=Filamin 5
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548764_8662892648.0RepeatNote=Filamin 6
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548867_9652892648.0RepeatNote=Filamin 7
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-548966_10612892648.0RepeatNote=Filamin 8
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471062_11542892640.0RepeatNote=Filamin 9
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471155_12492892640.0RepeatNote=Filamin 10
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471250_13492892640.0RepeatNote=Filamin 11
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471350_14422892640.0RepeatNote=Filamin 12
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471443_15392892640.0RepeatNote=Filamin 13
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471540_16362892640.0RepeatNote=Filamin 14
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471649_17402892640.0RepeatNote=Filamin 15
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471779_18602892640.0RepeatNote=Filamin 16
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471861_19502892640.0RepeatNote=Filamin 17
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471951_20392892640.0RepeatNote=Filamin 18
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472042_21312892640.0RepeatNote=Filamin 19
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472132_22302892640.0RepeatNote=Filamin 20
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472233_23252892640.0RepeatNote=Filamin 21
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472327_24202892640.0RepeatNote=Filamin 22
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472424_25162892640.0RepeatNote=Filamin 23
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5472552_26462892640.0RepeatNote=Filamin 24
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547276_3742892640.0RepeatNote=Filamin 1
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547376_4742892640.0RepeatNote=Filamin 2
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547475_5702892640.0RepeatNote=Filamin 3
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547571_6632892640.0RepeatNote=Filamin 4
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547667_7632892640.0RepeatNote=Filamin 5
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547764_8662892640.0RepeatNote=Filamin 6
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547867_9652892640.0RepeatNote=Filamin 7
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-547966_10612892640.0RepeatNote=Filamin 8


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Fusion Gene Sequence for FLNA-ACTG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30627_30627_1_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000344736_ACTG2_chr2_74140612_ENST00000345517_length(transcript)=1881nt_BP=911nt
GCCGAGGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGGGCGGGCCAGAGCGCAGCAGGCGCGGC
TCCGGGCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAGGACGCGCCGTGGAAGAAGATCCAGCA
GAACACTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTGCAGACGGACCTGAGCGACGGGCTGCG
GCTTATCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCCACTTTCCGCCAAATGCAGCTTGAGAA
CGTGTCGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAGGCCATCGTGGACGGGAACCTGAAGCT
GATCCTGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAGGAGGAGGATGAGGAGGCCAAGAAGCA
GACCCCCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAACTTCAGCCGGGACTGGCAGAGCGGCCG
GGCCCTGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGACGCCAGCAAGCCCGTTACCAATGCGCG
AGAGGCCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATTGTGGACCCCAACGTGGACGAGCACTC
TGTCATGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCCAAACTGAACCCGAAGAAAGCCCGTGC
CTACGGGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAAGGCTATGCCCTGCCCCATGCCATCAT
GCGCCTGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCCTTTGTGACCACAGCTGAGAG
AGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCTTCCTCTTCCTCCCT
GGAGAAGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAGACCCTCTTCCAGCCTTCCTT
TATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATTGACATCCGTAAGGACTTATATGCCAA
CAATGTCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCCCTGGCCCCCAGCACCATGAA
GATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACCTTCCAGCAGATGTG
GATCAGCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGTCAGAACAGGTTCTCCAAGGATCCCCT
CGAGACTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGGCTCTTTTTTCCTGGGCTATGTCTCAT
ACACAGTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTGCTATCATTATACCCATATTACAGATG

>30627_30627_1_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000344736_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------
>30627_30627_2_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000344736_ACTG2_chr2_74140612_ENST00000409731_length(transcript)=1881nt_BP=911nt
GCCGAGGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGGGCGGGCCAGAGCGCAGCAGGCGCGGC
TCCGGGCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAGGACGCGCCGTGGAAGAAGATCCAGCA
GAACACTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTGCAGACGGACCTGAGCGACGGGCTGCG
GCTTATCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCCACTTTCCGCCAAATGCAGCTTGAGAA
CGTGTCGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAGGCCATCGTGGACGGGAACCTGAAGCT
GATCCTGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAGGAGGAGGATGAGGAGGCCAAGAAGCA
GACCCCCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAACTTCAGCCGGGACTGGCAGAGCGGCCG
GGCCCTGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGACGCCAGCAAGCCCGTTACCAATGCGCG
AGAGGCCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATTGTGGACCCCAACGTGGACGAGCACTC
TGTCATGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCCAAACTGAACCCGAAGAAAGCCCGTGC
CTACGGGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAAGGCTATGCCCTGCCCCATGCCATCAT
GCGCCTGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCCTTTGTGACCACAGCTGAGAG
AGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCTTCCTCTTCCTCCCT
GGAGAAGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAGACCCTCTTCCAGCCTTCCTT
TATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATTGACATCCGTAAGGACTTATATGCCAA
CAATGTCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCCCTGGCCCCCAGCACCATGAA
GATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACCTTCCAGCAGATGTG
GATCAGCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGTCAGAACAGGTTCTCCAAGGATCCCCT
CGAGACTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGGCTCTTTTTTCCTGGGCTATGTCTCAT
ACACAGTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTGCTATCATTATACCCATATTACAGATG

>30627_30627_2_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000344736_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------
>30627_30627_3_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000360319_ACTG2_chr2_74140612_ENST00000345517_length(transcript)=1876nt_BP=906nt
GGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGGGCGGGCCAGAGCGCAGCAGGCGCGGCTCCGG
GCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAGGACGCGCCGTGGAAGAAGATCCAGCAGAACA
CTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTGCAGACGGACCTGAGCGACGGGCTGCGGCTTA
TCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCCACTTTCCGCCAAATGCAGCTTGAGAACGTGT
CGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAGGCCATCGTGGACGGGAACCTGAAGCTGATCC
TGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAGGAGGAGGATGAGGAGGCCAAGAAGCAGACCC
CCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAACTTCAGCCGGGACTGGCAGAGCGGCCGGGCCC
TGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGACGCCAGCAAGCCCGTTACCAATGCGCGAGAGG
CCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATTGTGGACCCCAACGTGGACGAGCACTCTGTCA
TGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCCAAACTGAACCCGAAGAAAGCCCGTGCCTACG
GGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAAGGCTATGCCCTGCCCCATGCCATCATGCGCC
TGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCCTTTGTGACCACAGCTGAGAGAGAAA
TTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCTTCCTCTTCCTCCCTGGAGA
AGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAGACCCTCTTCCAGCCTTCCTTTATTG
GCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATTGACATCCGTAAGGACTTATATGCCAACAATG
TCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCCCTGGCCCCCAGCACCATGAAGATCA
AGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACCTTCCAGCAGATGTGGATCA
GCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGTCAGAACAGGTTCTCCAAGGATCCCCTCGAGA
CTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGGCTCTTTTTTCCTGGGCTATGTCTCATACACA
GTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTGCTATCATTATACCCATATTACAGATGAGGAA

>30627_30627_3_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000360319_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
LQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------
>30627_30627_4_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000360319_ACTG2_chr2_74140612_ENST00000409731_length(transcript)=1876nt_BP=906nt
GGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGGGCGGGCCAGAGCGCAGCAGGCGCGGCTCCGG
GCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAGGACGCGCCGTGGAAGAAGATCCAGCAGAACA
CTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTGCAGACGGACCTGAGCGACGGGCTGCGGCTTA
TCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCCACTTTCCGCCAAATGCAGCTTGAGAACGTGT
CGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAGGCCATCGTGGACGGGAACCTGAAGCTGATCC
TGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAGGAGGAGGATGAGGAGGCCAAGAAGCAGACCC
CCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAACTTCAGCCGGGACTGGCAGAGCGGCCGGGCCC
TGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGACGCCAGCAAGCCCGTTACCAATGCGCGAGAGG
CCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATTGTGGACCCCAACGTGGACGAGCACTCTGTCA
TGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCCAAACTGAACCCGAAGAAAGCCCGTGCCTACG
GGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAAGGCTATGCCCTGCCCCATGCCATCATGCGCC
TGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCCTTTGTGACCACAGCTGAGAGAGAAA
TTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCTTCCTCTTCCTCCCTGGAGA
AGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAGACCCTCTTCCAGCCTTCCTTTATTG
GCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATTGACATCCGTAAGGACTTATATGCCAACAATG
TCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCCCTGGCCCCCAGCACCATGAAGATCA
AGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACCTTCCAGCAGATGTGGATCA
GCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGTCAGAACAGGTTCTCCAAGGATCCCCTCGAGA
CTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGGCTCTTTTTTCCTGGGCTATGTCTCATACACA
GTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTGCTATCATTATACCCATATTACAGATGAGGAA

>30627_30627_4_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000360319_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
LQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------
>30627_30627_5_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000369850_ACTG2_chr2_74140612_ENST00000345517_length(transcript)=2075nt_BP=1105nt
GCGCGTCGCGCGCAGCGGACGCCGACAGAATCCCCGAGGCGCCTGGCGCGGGCGCGGGCGCGAAGGCGATCCGGGCGCCACCCCGCGGTC
ATCGGTCACCGGTCGCTCTCAGGAACAGCAGCGCAACCTCTGCTCCCTGCCTCGCCTCCCGCGCGCCTAGGTGCCTGCGACTTTAATTAA
AGGGCCGTCCCCTCGCCGAGGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGGGCGGGCCAGAGC
GCAGCAGGCGCGGCTCCGGGCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAGGACGCGCCGTGG
AAGAAGATCCAGCAGAACACTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTGCAGACGGACCTG
AGCGACGGGCTGCGGCTTATCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCCACTTTCCGCCAA
ATGCAGCTTGAGAACGTGTCGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAGGCCATCGTGGAC
GGGAACCTGAAGCTGATCCTGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAGGAGGAGGATGAG
GAGGCCAAGAAGCAGACCCCCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAACTTCAGCCGGGAC
TGGCAGAGCGGCCGGGCCCTGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGACGCCAGCAAGCCC
GTTACCAATGCGCGAGAGGCCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATTGTGGACCCCAAC
GTGGACGAGCACTCTGTCATGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCCAAACTGAACCCG
AAGAAAGCCCGTGCCTACGGGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAAGGCTATGCCCTG
CCCCATGCCATCATGCGCCTGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCCTTTGTG
ACCACAGCTGAGAGAGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCT
TCCTCTTCCTCCCTGGAGAAGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAGACCCTC
TTCCAGCCTTCCTTTATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATTGACATCCGTAAG
GACTTATATGCCAACAATGTCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCCCTGGCC
CCCAGCACCATGAAGATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACC
TTCCAGCAGATGTGGATCAGCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGTCAGAACAGGTTC
TCCAAGGATCCCCTCGAGACTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGGCTCTTTTTTCCT
GGGCTATGTCTCATACACAGTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTGCTATCATTATAC
CCATATTACAGATGAGGAAATTGAGGCTCAGAGAAGTCAAGGACTTGCGAAGATCACACAGATTCCAGATTAAAATTCAAGTATCTGACT

>30627_30627_5_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000369850_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

--------------------------------------------------------------
>30627_30627_6_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000369850_ACTG2_chr2_74140612_ENST00000409731_length(transcript)=2075nt_BP=1105nt
GCGCGTCGCGCGCAGCGGACGCCGACAGAATCCCCGAGGCGCCTGGCGCGGGCGCGGGCGCGAAGGCGATCCGGGCGCCACCCCGCGGTC
ATCGGTCACCGGTCGCTCTCAGGAACAGCAGCGCAACCTCTGCTCCCTGCCTCGCCTCCCGCGCGCCTAGGTGCCTGCGACTTTAATTAA
AGGGCCGTCCCCTCGCCGAGGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGGGCGGGCCAGAGC
GCAGCAGGCGCGGCTCCGGGCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAGGACGCGCCGTGG
AAGAAGATCCAGCAGAACACTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTGCAGACGGACCTG
AGCGACGGGCTGCGGCTTATCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCCACTTTCCGCCAA
ATGCAGCTTGAGAACGTGTCGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAGGCCATCGTGGAC
GGGAACCTGAAGCTGATCCTGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAGGAGGAGGATGAG
GAGGCCAAGAAGCAGACCCCCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAACTTCAGCCGGGAC
TGGCAGAGCGGCCGGGCCCTGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGACGCCAGCAAGCCC
GTTACCAATGCGCGAGAGGCCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATTGTGGACCCCAAC
GTGGACGAGCACTCTGTCATGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCCAAACTGAACCCG
AAGAAAGCCCGTGCCTACGGGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAAGGCTATGCCCTG
CCCCATGCCATCATGCGCCTGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCCTTTGTG
ACCACAGCTGAGAGAGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCT
TCCTCTTCCTCCCTGGAGAAGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAGACCCTC
TTCCAGCCTTCCTTTATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATTGACATCCGTAAG
GACTTATATGCCAACAATGTCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCCCTGGCC
CCCAGCACCATGAAGATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACC
TTCCAGCAGATGTGGATCAGCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGTCAGAACAGGTTC
TCCAAGGATCCCCTCGAGACTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGGCTCTTTTTTCCT
GGGCTATGTCTCATACACAGTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTGCTATCATTATAC
CCATATTACAGATGAGGAAATTGAGGCTCAGAGAAGTCAAGGACTTGCGAAGATCACACAGATTCCAGATTAAAATTCAAGTATCTGACT

>30627_30627_6_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000369850_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

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>30627_30627_7_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000422373_ACTG2_chr2_74140612_ENST00000345517_length(transcript)=2087nt_BP=1117nt
ATTCGCGTGGAGGCGCGTCGCGCGCAGCGGACGCCGACAGAATCCCCGAGGCGCCTGGCGCGGGCGCGGGCGCGAAGGCGATCCGGGCGC
CACCCCGCGGTCATCGGTCACCGGTCGCTCTCAGGAACAGCAGCGCAACCTCTGCTCCCTGCCTCGCCTCCCGCGCGCCTAGGTGCCTGC
GACTTTAATTAAAGGGCCGTCCCCTCGCCGAGGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGG
GCGGGCCAGAGCGCAGCAGGCGCGGCTCCGGGCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAG
GACGCGCCGTGGAAGAAGATCCAGCAGAACACTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTG
CAGACGGACCTGAGCGACGGGCTGCGGCTTATCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCC
ACTTTCCGCCAAATGCAGCTTGAGAACGTGTCGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAG
GCCATCGTGGACGGGAACCTGAAGCTGATCCTGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAG
GAGGAGGATGAGGAGGCCAAGAAGCAGACCCCCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAAC
TTCAGCCGGGACTGGCAGAGCGGCCGGGCCCTGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGAC
GCCAGCAAGCCCGTTACCAATGCGCGAGAGGCCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATT
GTGGACCCCAACGTGGACGAGCACTCTGTCATGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCC
AAACTGAACCCGAAGAAAGCCCGTGCCTACGGGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAA
GGCTATGCCCTGCCCCATGCCATCATGCGCCTGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGC
TATTCCTTTGTGACCACAGCTGAGAGAGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATG
GCCACAGCAGCTTCCTCTTCCTCCCTGGAGAAGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGC
CCTGAGACCCTCTTCCAGCCTTCCTTTATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATT
GACATCCGTAAGGACTTATATGCCAACAATGTCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATC
ACAGCCCTGGCCCCCAGCACCATGAAGATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCC
TCTCTCTCCACCTTCCAGCAGATGTGGATCAGCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGT
CAGAACAGGTTCTCCAAGGATCCCCTCGAGACTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGG
CTCTTTTTTCCTGGGCTATGTCTCATACACAGTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTG
CTATCATTATACCCATATTACAGATGAGGAAATTGAGGCTCAGAGAAGTCAAGGACTTGCGAAGATCACACAGATTCCAGATTAAAATTC

>30627_30627_7_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000422373_ACTG2_chr2_74140612_ENST00000345517_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

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>30627_30627_8_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000422373_ACTG2_chr2_74140612_ENST00000409731_length(transcript)=2087nt_BP=1117nt
ATTCGCGTGGAGGCGCGTCGCGCGCAGCGGACGCCGACAGAATCCCCGAGGCGCCTGGCGCGGGCGCGGGCGCGAAGGCGATCCGGGCGC
CACCCCGCGGTCATCGGTCACCGGTCGCTCTCAGGAACAGCAGCGCAACCTCTGCTCCCTGCCTCGCCTCCCGCGCGCCTAGGTGCCTGC
GACTTTAATTAAAGGGCCGTCCCCTCGCCGAGGCTGCAGCACCGCCCCCCCGGCTTCTCGCGCCTCAAAATGAGTAGCTCCCACTCTCGG
GCGGGCCAGAGCGCAGCAGGCGCGGCTCCGGGCGGCGGCGTCGACACGCGGGACGCCGAGATGCCGGCCACCGAGAAGGACCTGGCGGAG
GACGCGCCGTGGAAGAAGATCCAGCAGAACACTTTCACGCGCTGGTGCAACGAGCACCTGAAGTGCGTGAGCAAGCGCATCGCCAACCTG
CAGACGGACCTGAGCGACGGGCTGCGGCTTATCGCGCTGTTGGAGGTGCTCAGCCAGAAGAAGATGCACCGCAAGCACAACCAGCGGCCC
ACTTTCCGCCAAATGCAGCTTGAGAACGTGTCGGTGGCGCTCGAGTTCCTGGACCGCGAGAGCATCAAACTGGTGTCCATCGACAGCAAG
GCCATCGTGGACGGGAACCTGAAGCTGATCCTGGGCCTCATCTGGACCCTGATCCTGCACTACTCCATCTCCATGCCCATGTGGGACGAG
GAGGAGGATGAGGAGGCCAAGAAGCAGACCCCCAAGCAGAGGCTCCTGGGCTGGATCCAGAACAAGCTGCCGCAGCTGCCCATCACCAAC
TTCAGCCGGGACTGGCAGAGCGGCCGGGCCCTGGGCGCCCTGGTGGACAGCTGTGCCCCGGGCCTGTGTCCTGACTGGGACTCTTGGGAC
GCCAGCAAGCCCGTTACCAATGCGCGAGAGGCCATGCAGCAGGCGGATGACTGGCTGGGCATCCCCCAGGTGATCACCCCCGAGGAGATT
GTGGACCCCAACGTGGACGAGCACTCTGTCATGACCTACCTGTCCCAGTTCCCCAAGGCCAAGCTGAAGCCAGGGGCTCCCTTGCGGCCC
AAACTGAACCCGAAGAAAGCCCGTGCCTACGGGCCAGGCATCGTCCTGGATTCAGGTGATGGCGTCACCCACAATGTCCCCATCTATGAA
GGCTATGCCCTGCCCCATGCCATCATGCGCCTGGACTTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGC
TATTCCTTTGTGACCACAGCTGAGAGAGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTGGCCCTGGATTTTGAGAATGAGATG
GCCACAGCAGCTTCCTCTTCCTCCCTGGAGAAGAGCTATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGC
CCTGAGACCCTCTTCCAGCCTTCCTTTATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTACAATTCCATCATGAAGTGTGACATT
GACATCCGTAAGGACTTATATGCCAACAATGTCCTCTCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATC
ACAGCCCTGGCCCCCAGCACCATGAAGATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTCTGGATCGGGGGCTCTATCCTGGCC
TCTCTCTCCACCTTCCAGCAGATGTGGATCAGCAAGCCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAAAGT
CAGAACAGGTTCTCCAAGGATCCCCTCGAGACTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTTACTTCTCTGTGTGGGG
CTCTTTTTTCCTGGGCTATGTCTCATACACAGTGCTAAGGACTTTTCACACATTACTTTTAATCCATGCAATAGTGCTGTAAGGTAGGTG
CTATCATTATACCCATATTACAGATGAGGAAATTGAGGCTCAGAGAAGTCAAGGACTTGCGAAGATCACACAGATTCCAGATTAAAATTC

>30627_30627_8_FLNA-ACTG2_FLNA_chrX_153595765_ENST00000422373_ACTG2_chr2_74140612_ENST00000409731_length(amino acids)=527AA_BP=301
MQHRPPGFSRLKMSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLI
ALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTP
KQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVM
TYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREI
VRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV

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Fusion Gene PPI Analysis for FLNA-ACTG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFLNAchrX:153595765chr2:74140612ENST00000360319-4461490_1607289.33333333333332640.0furin
HgeneFLNAchrX:153595765chr2:74140612ENST00000369850-5481490_1607289.33333333333332648.0furin
HgeneFLNAchrX:153595765chr2:74140612ENST00000422373-5471490_1607289.33333333333332640.0furin


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FLNA-ACTG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FLNA-ACTG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource