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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FLNB-CSNK1A1 (FusionGDB2 ID:30656)

Fusion Gene Summary for FLNB-CSNK1A1

Fusion gene summary

Fusion gene information	Fusion gene name: FLNB-CSNK1A1
	Fusion gene ID: 30656
		Hgene	Tgene
	Gene symbol	FLNB	CSNK1A1
	Gene ID	2317	1452
	Gene name	filamin B	casein kinase 1 alpha 1
	Synonyms	ABP-278\|ABP-280\|AOI\|FH1\|FLN-B\|FLN1L\|LRS1\|SCT\|TABP\|TAP	CK1\|CK1a\|CKIa\|HEL-S-77p\|HLCDGP1\|PRO2975
	Cytomap	3p14.3	5q32
	Type of gene	protein-coding	protein-coding
	Description	filamin-BABP-280 homologLarsen syndrome 1 (autosomal dominant)actin binding protein 278actin-binding-like proteinbeta-filaminfilamin B, betafilamin homolog 1filamin-3thyroid autoantigen	casein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77p
	Modification date	20200313	20200313
	UniProtAcc	O75369	P48729
	Ensembl transtripts involved in fusion gene	ENST00000295956, ENST00000348383, ENST00000357272, ENST00000358537, ENST00000419752, ENST00000429972, ENST00000484981, ENST00000490882, ENST00000493452,	ENST00000261798, ENST00000377843, ENST00000504676, ENST00000515435, ENST00000515748, ENST00000515768, ENST00000606299, ENST00000606719,
Fusion gene scores	* DoF score	14 X 17 X 10=2380	12 X 13 X 6=936
	# samples	25	15
	** MAII score	log2(25/2380*10)=-3.25096157353322 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/936*10)=-2.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FLNB [Title/Abstract] AND CSNK1A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FLNB(58148593)-CSNK1A1(148873902), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CSNK1A1	GO:0006468	protein phosphorylation	18305108
Tgene	CSNK1A1	GO:0018105	peptidyl-serine phosphorylation	25500533
Tgene	CSNK1A1	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	19364825

Fusion gene breakpoints across FLNB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CSNK1A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF059773	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
ChiTaRS5.0	N/A	BM972490	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
ChiTaRS5.0	N/A	CA433277	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+

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Fusion Gene ORF analysis for FLNB-CSNK1A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000295956	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000348383	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000357272	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000358537	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000419752	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000429972	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000484981	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000490882	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-3UTR	ENST00000493452	ENST00000261798	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000295956	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000295956	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000295956	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000295956	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000295956	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000295956	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000295956	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000348383	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000348383	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000348383	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000348383	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000348383	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000348383	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000348383	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000357272	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000357272	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000357272	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000357272	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000357272	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000357272	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000357272	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000358537	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000358537	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000358537	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000358537	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000358537	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000358537	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000358537	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000419752	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000419752	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000419752	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000419752	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000419752	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000419752	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000419752	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000429972	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000429972	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000429972	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000429972	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000429972	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000429972	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000429972	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000484981	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000484981	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000484981	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000484981	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000484981	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000484981	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000484981	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000490882	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000490882	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000490882	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000490882	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000490882	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000490882	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000490882	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000493452	ENST00000377843	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000493452	ENST00000504676	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000493452	ENST00000515435	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000493452	ENST00000515748	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000493452	ENST00000515768	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000493452	ENST00000606299	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+
intron-intron	ENST00000493452	ENST00000606719	FLNB	chr3	58148593	+	CSNK1A1	chr5	148873902	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for FLNB-CSNK1A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FLNB-CSNK1A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:58148593/:148873902)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FLNB O75369	CSNK1A1 P48729
FUNCTION: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.	FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269\|PubMed:11955436, ECO:0000269\|PubMed:1409656, ECO:0000269\|PubMed:18305108, ECO:0000269\|PubMed:23902688}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for FLNB-CSNK1A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FLNB-CSNK1A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FLNB-CSNK1A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FLNB-CSNK1A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source