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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FLNB-FLNB (FusionGDB2 ID:30658)

Fusion Gene Summary for FLNB-FLNB

Fusion gene summary

Fusion gene information	Fusion gene name: FLNB-FLNB
	Fusion gene ID: 30658
		Hgene	Tgene
	Gene symbol	FLNB	FLNB
	Gene ID	2317	2317
	Gene name	filamin B	filamin B
	Synonyms	ABP-278\|ABP-280\|AOI\|FH1\|FLN-B\|FLN1L\|LRS1\|SCT\|TABP\|TAP	ABP-278\|ABP-280\|AOI\|FH1\|FLN-B\|FLN1L\|LRS1\|SCT\|TABP\|TAP
	Cytomap	3p14.3	3p14.3
	Type of gene	protein-coding	protein-coding
	Description	filamin-BABP-280 homologLarsen syndrome 1 (autosomal dominant)actin binding protein 278actin-binding-like proteinbeta-filaminfilamin B, betafilamin homolog 1filamin-3thyroid autoantigen	filamin-BABP-280 homologLarsen syndrome 1 (autosomal dominant)actin binding protein 278actin-binding-like proteinbeta-filaminfilamin B, betafilamin homolog 1filamin-3thyroid autoantigen
	Modification date	20200313	20200313
	UniProtAcc	O75369	O75369
	Ensembl transtripts involved in fusion gene	ENST00000295956, ENST00000348383, ENST00000357272, ENST00000358537, ENST00000419752, ENST00000429972, ENST00000490882, ENST00000493452, ENST00000484981,	ENST00000295956, ENST00000348383, ENST00000357272, ENST00000358537, ENST00000419752, ENST00000429972, ENST00000484981, ENST00000490882, ENST00000493452,
Fusion gene scores	* DoF score	14 X 17 X 10=2380	19 X 22 X 8=3344
	# samples	25	23
	** MAII score	log2(25/2380*10)=-3.25096157353322 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/3344*10)=-3.86186908113651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FLNB [Title/Abstract] AND FLNB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FLNB(58095849)-FLNB(58107015), # samples:1 FLNB(58157318)-FLNB(58157605), # samples:1 FLNB(58113162)-FLNB(58113396), # samples:1 FLNB(58113396)-FLNB(58113162), # samples:1
Anticipated loss of major functional domain due to fusion event.	FLNB-FLNB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FLNB-FLNB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FLNB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FLNB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AI905910	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
ChiTaRS5.0	N/A	AW842251	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
ChiTaRS5.0	N/A	BG987842	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
ChiTaRS5.0	N/A	BG992732	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+

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Fusion Gene ORF analysis for FLNB-FLNB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000295956	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000295956	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000295956	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000295956	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000295956	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000295956	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000348383	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000348383	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000348383	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000348383	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000348383	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000348383	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000357272	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000357272	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000357272	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000357272	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000357272	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000357272	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000358537	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000358537	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000358537	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000358537	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000358537	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000358537	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000419752	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000419752	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000419752	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000419752	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000419752	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000419752	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000429972	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000429972	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000429972	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000429972	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000429972	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-3UTR	ENST00000429972	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000295956	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000295956	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000295956	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000348383	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000348383	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000348383	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000357272	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000357272	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000357272	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000358537	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000358537	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000358537	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000419752	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000419752	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000419752	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000429972	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000429972	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
3UTR-intron	ENST00000429972	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
5CDS-intron	ENST00000295956	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
5CDS-intron	ENST00000348383	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
5CDS-intron	ENST00000357272	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
5CDS-intron	ENST00000358537	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
5CDS-intron	ENST00000419752	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
5CDS-intron	ENST00000429972	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
5CDS-intron	ENST00000490882	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
5CDS-intron	ENST00000493452	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000295956	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000348383	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000357272	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000358537	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000419752	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000429972	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000490882	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
Frame-shift	ENST00000493452	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000295956	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000348383	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000357272	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000358537	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000419752	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000429972	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000490882	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3CDS	ENST00000484981	ENST00000493452	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-3UTR	ENST00000484981	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000484981	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000484981	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000484981	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000484981	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000484981	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000490882	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000490882	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000490882	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000490882	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000490882	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000490882	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000493452	ENST00000295956	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000493452	ENST00000348383	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000493452	ENST00000357272	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000493452	ENST00000358537	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000493452	ENST00000419752	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-3UTR	ENST00000493452	ENST00000429972	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000295956	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000295956	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000295956	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000348383	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000348383	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000357272	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000357272	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000358537	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000358537	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000419752	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000419752	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000429972	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000429972	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000484981	FLNB	chr3	58095849	-	FLNB	chr3	58107015	+
intron-intron	ENST00000484981	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000484981	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000484981	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000484981	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000484981	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000484981	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000490882	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000490882	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000490882	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000490882	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000490882	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000295956	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000295956	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000348383	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000348383	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000357272	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000357272	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000358537	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000358537	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000419752	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000419752	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000429972	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000429972	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000484981	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000493452	ENST00000484981	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000484981	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000490882	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000493452	ENST00000490882	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000490882	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+
intron-intron	ENST00000493452	ENST00000493452	FLNB	chr3	58157318	-	FLNB	chr3	58157605	+
intron-intron	ENST00000493452	ENST00000493452	FLNB	chr3	58113162	-	FLNB	chr3	58113396	+
intron-intron	ENST00000493452	ENST00000493452	FLNB	chr3	58113396	-	FLNB	chr3	58113162	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for FLNB-FLNB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FLNB-FLNB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:58095849/:58107015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FLNB O75369	FLNB O75369
FUNCTION: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.	FUNCTION: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for FLNB-FLNB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FLNB-FLNB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FLNB-FLNB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FLNB-FLNB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source