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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FLT4-NOC4L (FusionGDB2 ID:30705) |
Fusion Gene Summary for FLT4-NOC4L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FLT4-NOC4L | Fusion gene ID: 30705 | Hgene | Tgene | Gene symbol | FLT4 | NOC4L | Gene ID | 2324 | 79050 |
| Gene name | fms related receptor tyrosine kinase 4 | nucleolar complex associated 4 homolog | |
| Synonyms | CHTD7|FLT-4|FLT41|LMPH1A|LMPHM1|PCL|VEGFR-3|VEGFR3 | NET49|NOC4|UTP19 | |
| Cytomap | 5q35.3 | 12q24.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vascular endothelial growth factor receptor 3Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4VEGF receptor-3fms related tyrosine kinase 4fms-like tyrosine kinase 4primary congenital lymphedematyrosine-protein kinase receptor FLT4 | nucleolar complex protein 4 homologNOC4 protein homologNOC4-like proteinnucleolar complex-associated protein 4-like protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P35916 | Q9BVI4 | |
| Ensembl transtripts involved in fusion gene | ENST00000261937, ENST00000393347, ENST00000502649, ENST00000424276, | ENST00000538784, ENST00000535343, ENST00000330579, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 36 X 4 X 20=2880 |
| # samples | 1 | 41 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(41/2880*10)=-2.81237299682423 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FLT4 [Title/Abstract] AND NOC4L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FLT4(180076487)-NOC4L(132635525), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FLT4-NOC4L seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. FLT4-NOC4L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FLT4-NOC4L seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. FLT4-NOC4L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FLT4 | GO:0018108 | peptidyl-tyrosine phosphorylation | 7898938 |
| Hgene | FLT4 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 9435229 |
| Hgene | FLT4 | GO:0038084 | vascular endothelial growth factor signaling pathway | 23878260 |
| Hgene | FLT4 | GO:0046777 | protein autophosphorylation | 7675451|9435229|23878260 |
| Hgene | FLT4 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 9012504 |
| Fusion gene breakpoints across FLT4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across NOC4L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | TCGA-BC-A110-11A | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
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Fusion Gene ORF analysis for FLT4-NOC4L |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000261937 | ENST00000538784 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5CDS-5UTR | ENST00000393347 | ENST00000538784 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5CDS-5UTR | ENST00000502649 | ENST00000538784 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5CDS-intron | ENST00000261937 | ENST00000535343 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5CDS-intron | ENST00000393347 | ENST00000535343 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5CDS-intron | ENST00000502649 | ENST00000535343 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5UTR-3CDS | ENST00000424276 | ENST00000330579 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5UTR-5UTR | ENST00000424276 | ENST00000538784 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| 5UTR-intron | ENST00000424276 | ENST00000535343 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| Frame-shift | ENST00000261937 | ENST00000330579 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| Frame-shift | ENST00000393347 | ENST00000330579 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| Frame-shift | ENST00000502649 | ENST00000330579 | FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FLT4-NOC4L |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + | 0.023907928 | 0.97609216 |
| FLT4 | chr5 | 180076487 | - | NOC4L | chr12 | 132635525 | + | 0.023907928 | 0.97609216 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FLT4-NOC4L |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:180076487/:132635525) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FLT4 | NOC4L |
| FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FLT4-NOC4L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for FLT4-NOC4L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FLT4-NOC4L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FLT4-NOC4L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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