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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FLVCR2-JDP2 (FusionGDB2 ID:30709)

Fusion Gene Summary for FLVCR2-JDP2

check button Fusion gene summary
Fusion gene informationFusion gene name: FLVCR2-JDP2
Fusion gene ID: 30709
HgeneTgene
Gene symbol

FLVCR2

JDP2

Gene ID

55640

122953

Gene nameFLVCR heme transporter 2Jun dimerization protein 2
SynonymsC14orf58|CCT|EPV|FLVCRL14q|MFSD7C|PVHH|SLC49A2JUNDM2
Cytomap

14q24.3

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionfeline leukemia virus subgroup C receptor-related protein 2calcium-chelate transporterfeline leukemia virus subgroup C cellular receptor family member 2jun dimerization protein 2progesterone receptor co-activator
Modification date2020031320200313
UniProtAcc

Q9UPI3

Q8WYK2

Ensembl transtripts involved in fusion geneENST00000556241, ENST00000238667, 
ENST00000539311, ENST00000553587, 
ENST00000555027, ENST00000556856, 
ENST00000419727, ENST00000267569, 
ENST00000435893, ENST00000437176, 
ENST00000559773, 
Fusion gene scores* DoF score4 X 5 X 4=804 X 5 X 4=80
# samples 46
** MAII scorelog2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLVCR2 [Title/Abstract] AND JDP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFLVCR2(76101356)-JDP2(75935993), # samples:2
JDP2(75899039)-FLVCR2(76088422), # samples:2
Anticipated loss of major functional domain due to fusion event.JDP2-FLVCR2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
JDP2-FLVCR2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
JDP2-FLVCR2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
JDP2-FLVCR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
JDP2-FLVCR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FLVCR2-JDP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FLVCR2-JDP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FLVCR2-JDP2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
FLVCR2-JDP2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
FLVCR2-JDP2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneJDP2

GO:0000122

negative regulation of transcription by RNA polymerase II

18671972


check buttonFusion gene breakpoints across FLVCR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across JDP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-4R-AA8I-01AFLVCR2chr14

76101356

+JDP2chr14

75935993

+


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Fusion Gene ORF analysis for FLVCR2-JDP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000556241ENST00000419727FLVCR2chr14

76101356

+JDP2chr14

75935993

+
3UTR-intronENST00000556241ENST00000267569FLVCR2chr14

76101356

+JDP2chr14

75935993

+
3UTR-intronENST00000556241ENST00000435893FLVCR2chr14

76101356

+JDP2chr14

75935993

+
3UTR-intronENST00000556241ENST00000437176FLVCR2chr14

76101356

+JDP2chr14

75935993

+
3UTR-intronENST00000556241ENST00000559773FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000238667ENST00000267569FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000238667ENST00000435893FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000238667ENST00000437176FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000238667ENST00000559773FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000539311ENST00000267569FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000539311ENST00000435893FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000539311ENST00000437176FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000539311ENST00000559773FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000553587ENST00000267569FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000553587ENST00000435893FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000553587ENST00000437176FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000553587ENST00000559773FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000555027ENST00000267569FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000555027ENST00000435893FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000555027ENST00000437176FLVCR2chr14

76101356

+JDP2chr14

75935993

+
5CDS-intronENST00000555027ENST00000559773FLVCR2chr14

76101356

+JDP2chr14

75935993

+
Frame-shiftENST00000238667ENST00000419727FLVCR2chr14

76101356

+JDP2chr14

75935993

+
Frame-shiftENST00000539311ENST00000419727FLVCR2chr14

76101356

+JDP2chr14

75935993

+
Frame-shiftENST00000553587ENST00000419727FLVCR2chr14

76101356

+JDP2chr14

75935993

+
Frame-shiftENST00000555027ENST00000419727FLVCR2chr14

76101356

+JDP2chr14

75935993

+
intron-3CDSENST00000556856ENST00000419727FLVCR2chr14

76101356

+JDP2chr14

75935993

+
intron-intronENST00000556856ENST00000267569FLVCR2chr14

76101356

+JDP2chr14

75935993

+
intron-intronENST00000556856ENST00000435893FLVCR2chr14

76101356

+JDP2chr14

75935993

+
intron-intronENST00000556856ENST00000437176FLVCR2chr14

76101356

+JDP2chr14

75935993

+
intron-intronENST00000556856ENST00000559773FLVCR2chr14

76101356

+JDP2chr14

75935993

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FLVCR2-JDP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FLVCR2chr1476101356+JDP2chr1475935992+2.29E-060.99999774
FLVCR2chr1476101356+JDP2chr1475935992+2.29E-060.99999774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FLVCR2-JDP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76101356/:75935993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLVCR2

Q9UPI3

JDP2

Q8WYK2

FUNCTION: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism. {ECO:0000269|PubMed:20823265}.FUNCTION: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FLVCR2-JDP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FLVCR2-JDP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FLVCR2-JDP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FLVCR2-JDP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource