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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FMR1-NDUFS6 (FusionGDB2 ID:30784)

Fusion Gene Summary for FMR1-NDUFS6

check button Fusion gene summary
Fusion gene informationFusion gene name: FMR1-NDUFS6
Fusion gene ID: 30784
HgeneTgene
Gene symbol

FMR1

NDUFS6

Gene ID

106478973

4726

Gene nameFMR1 intronic transcript 1NADH:ubiquinone oxidoreductase subunit S6
SynonymsFMR1CI-13kA|CI-13kD-A|CI13KDA|MC1DN9
Cytomap

Xq27.3

5p15.33

Type of genencRNAprotein-coding
DescriptionFMR1 intronic transcript 1 (non-protein coding)fragile X mental retardation syndrome proteinNADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase 13 kDa-A subunitNADH:ubiquinone oxidoreductase NDUFS6 subunitcomplex I
Modification date2019032420200313
UniProtAcc.

O75380

Ensembl transtripts involved in fusion geneENST00000218200, ENST00000334557, 
ENST00000370470, ENST00000370471, 
ENST00000370475, ENST00000370477, 
ENST00000439526, ENST00000440235, 
ENST00000492846, 		ENST00000510329, 
ENST00000469176, ENST00000274137, 
Fusion gene scores* DoF score7 X 3 X 6=1264 X 2 X 2=16
# samples 74
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FMR1 [Title/Abstract] AND NDUFS6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFMR1(146993748)-NDUFS6(1814452), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FMR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NDUFS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721FMR1chrX

146993748

+NDUFS6chr5

1814452

+


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Fusion Gene ORF analysis for FMR1-NDUFS6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000218200ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
5CDS-intronENST00000334557ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
5CDS-intronENST00000370470ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
5CDS-intronENST00000370471ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
5CDS-intronENST00000370475ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
5CDS-intronENST00000370477ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
5CDS-intronENST00000439526ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
Frame-shiftENST00000218200ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
Frame-shiftENST00000334557ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
Frame-shiftENST00000370470ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
Frame-shiftENST00000370471ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
Frame-shiftENST00000370475ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
Frame-shiftENST00000370477ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
Frame-shiftENST00000439526ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
In-frameENST00000218200ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
In-frameENST00000334557ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
In-frameENST00000370470ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
In-frameENST00000370471ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
In-frameENST00000370475ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
In-frameENST00000370477ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
In-frameENST00000439526ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
intron-3CDSENST00000440235ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
intron-3CDSENST00000440235ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
intron-3CDSENST00000492846ENST00000274137FMR1chrX

146993748

+NDUFS6chr5

1814452

+
intron-3CDSENST00000492846ENST00000469176FMR1chrX

146993748

+NDUFS6chr5

1814452

+
intron-intronENST00000440235ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+
intron-intronENST00000492846ENST00000510329FMR1chrX

146993748

+NDUFS6chr5

1814452

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000218200FMR1chrX146993748+ENST00000274137NDUFS6chr51814452+11582807251105126
ENST00000370471FMR1chrX146993748+ENST00000274137NDUFS6chr51814452+11582807251105126
ENST00000370477FMR1chrX146993748+ENST00000274137NDUFS6chr51814452+11462687131093126
ENST00000334557FMR1chrX146993748+ENST00000274137NDUFS6chr51814452+10571796241004126
ENST00000439526FMR1chrX146993748+ENST00000274137NDUFS6chr51814452+10571796241004126
ENST00000370475FMR1chrX146993748+ENST00000274137NDUFS6chr51814452+10571796241004126
ENST00000370470FMR1chrX146993748+ENST00000274137NDUFS6chr51814452+92951496876126

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000218200ENST00000274137FMR1chrX146993748+NDUFS6chr51814452+0.26886830.73113173
ENST00000370471ENST00000274137FMR1chrX146993748+NDUFS6chr51814452+0.26886830.73113173
ENST00000370477ENST00000274137FMR1chrX146993748+NDUFS6chr51814452+0.187252970.81274706
ENST00000334557ENST00000274137FMR1chrX146993748+NDUFS6chr51814452+0.263362020.736638
ENST00000439526ENST00000274137FMR1chrX146993748+NDUFS6chr51814452+0.263362020.736638
ENST00000370475ENST00000274137FMR1chrX146993748+NDUFS6chr51814452+0.263362020.736638
ENST00000370470ENST00000274137FMR1chrX146993748+NDUFS6chr51814452+0.65608220.34391776

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Fusion Genomic Features for FMR1-NDUFS6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FMR1chrX146993748+NDUFS6chr51814452+1.05E-111
FMR1chrX146993748+NDUFS6chr51814452+1.05E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FMR1-NDUFS6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:146993748/chr5:1814452)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NDUFS6

O75380

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+117222_25117591.0DomainKH 1
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+117285_31417591.0DomainKH 2
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+1174_5017591.0DomainAgenet-like 1
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+11763_11517591.0DomainAgenet-like 2
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+117222_25117633.0DomainKH 1
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+117285_31417633.0DomainKH 2
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+1174_5017633.0DomainAgenet-like 1
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+11763_11517633.0DomainAgenet-like 2
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+117424_44317591.0MotifNuclear export signal
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+117424_44317633.0MotifNuclear export signal
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+1171_18417591.0RegionRequired for nuclear localization
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+117397_49117591.0RegionRequired for nuclear export
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+117534_54817591.0RegionNote=RNA-binding RGG-box
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+1171_18417633.0RegionRequired for nuclear localization
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+117397_49117633.0RegionRequired for nuclear export
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+117534_54817633.0RegionNote=RNA-binding RGG-box


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Fusion Gene Sequence for FMR1-NDUFS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30784_30784_1_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000218200_NDUFS6_chr5_1814452_ENST00000274137_length(transcript)=1158nt_BP=280nt
ACTTCCGGTGGAGGGCCGCCTCTGAGCGGGCGGCGGGCCGACGGCGAGCGCGGGCGGCGGCGGTGACGGAGGCGCCGCTGCCAGGGGGCG
TGCGGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCTGGGCCTCGAGCGCCCGCA
GCCCACCTCTCGGGGGCGGGCTCCCGGCGCTAGCAGGGCTGAAGAGAAGATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGC
TTTCTACAAGGTGAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAGCCCGTGAGCGAGGTGGAGACTCGGGTGATAGCGTGCGATGG
CGGCGGGGGAGCTCTTGGCCACCCAAAAGTGTATATAAACTTGGACAAAGAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTT
CAGACAGCACCACCACTAGAGCGTGTGGCACGCCGGGGGTCCCGCAGCATCCTGTGAGCATTTCCGCGGGGAAGCTGAGCACGTGAAGCT
CGCTGGTTCTGTGCGAAGGGTATTCCTGGTGCTGAATAAAGGGTGTTGCTGTCAAGGCTGACAATTTGTAAGTTTGTTTCTTTCATAGTC
TGGGCTTTGGAAGTGAACATCCACGTGGACATGGGTAGACATGCGAGTGGAAGCAGTGCCCGCTCCAGTGAGCCTGAGCTGCCTCCTGCC
GGCCGCTGCCTGCCTTACCGGCTGCTTCTGTGTGTCTCCTCTTATCCTTGGGGCCACGTGGGCTGCAGGAATGGGCGGGGGGCAGGGAAG
GAGAAGGAGAAGTGCCTCTTGTTTTGCAGATGCAACTGTGCTTCAGAGAGCCAAGGTGGGTCTTGAGGTGCATAGTGAAGGAGGGTGCCC
AGGCCTCAACTGGTCCTATGGGAAGGTCAGCCTCTCTCCTGTTGCTGGCTTGCAGAGCTGGTCTATCCGTCCGTCCTAGTCCCTATGTTG
AAATGTCAGATCTTAAAACCCAAGAATTTAAGCACTGGTTTGAAGGCATCGAAAGTCACATACTGGCCACATTAAGGACAGTCTATGTTT

>30784_30784_1_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000218200_NDUFS6_chr5_1814452_ENST00000274137_length(amino acids)=126AA_BP=
MPALPAASVCLLLSLGPRGLQEWAGGREGEGEVPLVLQMQLCFREPRWVLRCIVKEGAQASTGPMGRSASLLLLACRAGLSVRPSPYVEM

--------------------------------------------------------------
>30784_30784_2_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000334557_NDUFS6_chr5_1814452_ENST00000274137_length(transcript)=1057nt_BP=179nt
GGCGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCTGGGCCTCGAGCGCCCGCAGCCCACCTCTC
GGGGGCGGGCTCCCGGCGCTAGCAGGGCTGAAGAGAAGATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACAAGG
TGAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAGCCCGTGAGCGAGGTGGAGACTCGGGTGATAGCGTGCGATGGCGGCGGGGGAG
CTCTTGGCCACCCAAAAGTGTATATAAACTTGGACAAAGAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTTCAGACAGCACC
ACCACTAGAGCGTGTGGCACGCCGGGGGTCCCGCAGCATCCTGTGAGCATTTCCGCGGGGAAGCTGAGCACGTGAAGCTCGCTGGTTCTG
TGCGAAGGGTATTCCTGGTGCTGAATAAAGGGTGTTGCTGTCAAGGCTGACAATTTGTAAGTTTGTTTCTTTCATAGTCTGGGCTTTGGA
AGTGAACATCCACGTGGACATGGGTAGACATGCGAGTGGAAGCAGTGCCCGCTCCAGTGAGCCTGAGCTGCCTCCTGCCGGCCGCTGCCT
GCCTTACCGGCTGCTTCTGTGTGTCTCCTCTTATCCTTGGGGCCACGTGGGCTGCAGGAATGGGCGGGGGGCAGGGAAGGAGAAGGAGAA
GTGCCTCTTGTTTTGCAGATGCAACTGTGCTTCAGAGAGCCAAGGTGGGTCTTGAGGTGCATAGTGAAGGAGGGTGCCCAGGCCTCAACT
GGTCCTATGGGAAGGTCAGCCTCTCTCCTGTTGCTGGCTTGCAGAGCTGGTCTATCCGTCCGTCCTAGTCCCTATGTTGAAATGTCAGAT
CTTAAAACCCAAGAATTTAAGCACTGGTTTGAAGGCATCGAAAGTCACATACTGGCCACATTAAGGACAGTCTATGTTTTTAAAAGAGTA

>30784_30784_2_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000334557_NDUFS6_chr5_1814452_ENST00000274137_length(amino acids)=126AA_BP=
MPALPAASVCLLLSLGPRGLQEWAGGREGEGEVPLVLQMQLCFREPRWVLRCIVKEGAQASTGPMGRSASLLLLACRAGLSVRPSPYVEM

--------------------------------------------------------------
>30784_30784_3_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370470_NDUFS6_chr5_1814452_ENST00000274137_length(transcript)=929nt_BP=51nt
ATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACAAGGTGAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAG
CCCGTGAGCGAGGTGGAGACTCGGGTGATAGCGTGCGATGGCGGCGGGGGAGCTCTTGGCCACCCAAAAGTGTATATAAACTTGGACAAA
GAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTTCAGACAGCACCACCACTAGAGCGTGTGGCACGCCGGGGGTCCCGCAGCA
TCCTGTGAGCATTTCCGCGGGGAAGCTGAGCACGTGAAGCTCGCTGGTTCTGTGCGAAGGGTATTCCTGGTGCTGAATAAAGGGTGTTGC
TGTCAAGGCTGACAATTTGTAAGTTTGTTTCTTTCATAGTCTGGGCTTTGGAAGTGAACATCCACGTGGACATGGGTAGACATGCGAGTG
GAAGCAGTGCCCGCTCCAGTGAGCCTGAGCTGCCTCCTGCCGGCCGCTGCCTGCCTTACCGGCTGCTTCTGTGTGTCTCCTCTTATCCTT
GGGGCCACGTGGGCTGCAGGAATGGGCGGGGGGCAGGGAAGGAGAAGGAGAAGTGCCTCTTGTTTTGCAGATGCAACTGTGCTTCAGAGA
GCCAAGGTGGGTCTTGAGGTGCATAGTGAAGGAGGGTGCCCAGGCCTCAACTGGTCCTATGGGAAGGTCAGCCTCTCTCCTGTTGCTGGC
TTGCAGAGCTGGTCTATCCGTCCGTCCTAGTCCCTATGTTGAAATGTCAGATCTTAAAACCCAAGAATTTAAGCACTGGTTTGAAGGCAT
CGAAAGTCACATACTGGCCACATTAAGGACAGTCTATGTTTTTAAAAGAGTAAGGATTATAATGTAGTGTAACATAAAAATAAAAGTAGA

>30784_30784_3_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370470_NDUFS6_chr5_1814452_ENST00000274137_length(amino acids)=126AA_BP=
MPALPAASVCLLLSLGPRGLQEWAGGREGEGEVPLVLQMQLCFREPRWVLRCIVKEGAQASTGPMGRSASLLLLACRAGLSVRPSPYVEM

--------------------------------------------------------------
>30784_30784_4_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370471_NDUFS6_chr5_1814452_ENST00000274137_length(transcript)=1158nt_BP=280nt
ACTTCCGGTGGAGGGCCGCCTCTGAGCGGGCGGCGGGCCGACGGCGAGCGCGGGCGGCGGCGGTGACGGAGGCGCCGCTGCCAGGGGGCG
TGCGGCAGCGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCTGGGCCTCGAGCGCCCGCA
GCCCACCTCTCGGGGGCGGGCTCCCGGCGCTAGCAGGGCTGAAGAGAAGATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGC
TTTCTACAAGGTGAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAGCCCGTGAGCGAGGTGGAGACTCGGGTGATAGCGTGCGATGG
CGGCGGGGGAGCTCTTGGCCACCCAAAAGTGTATATAAACTTGGACAAAGAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTT
CAGACAGCACCACCACTAGAGCGTGTGGCACGCCGGGGGTCCCGCAGCATCCTGTGAGCATTTCCGCGGGGAAGCTGAGCACGTGAAGCT
CGCTGGTTCTGTGCGAAGGGTATTCCTGGTGCTGAATAAAGGGTGTTGCTGTCAAGGCTGACAATTTGTAAGTTTGTTTCTTTCATAGTC
TGGGCTTTGGAAGTGAACATCCACGTGGACATGGGTAGACATGCGAGTGGAAGCAGTGCCCGCTCCAGTGAGCCTGAGCTGCCTCCTGCC
GGCCGCTGCCTGCCTTACCGGCTGCTTCTGTGTGTCTCCTCTTATCCTTGGGGCCACGTGGGCTGCAGGAATGGGCGGGGGGCAGGGAAG
GAGAAGGAGAAGTGCCTCTTGTTTTGCAGATGCAACTGTGCTTCAGAGAGCCAAGGTGGGTCTTGAGGTGCATAGTGAAGGAGGGTGCCC
AGGCCTCAACTGGTCCTATGGGAAGGTCAGCCTCTCTCCTGTTGCTGGCTTGCAGAGCTGGTCTATCCGTCCGTCCTAGTCCCTATGTTG
AAATGTCAGATCTTAAAACCCAAGAATTTAAGCACTGGTTTGAAGGCATCGAAAGTCACATACTGGCCACATTAAGGACAGTCTATGTTT

>30784_30784_4_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370471_NDUFS6_chr5_1814452_ENST00000274137_length(amino acids)=126AA_BP=
MPALPAASVCLLLSLGPRGLQEWAGGREGEGEVPLVLQMQLCFREPRWVLRCIVKEGAQASTGPMGRSASLLLLACRAGLSVRPSPYVEM

--------------------------------------------------------------
>30784_30784_5_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370475_NDUFS6_chr5_1814452_ENST00000274137_length(transcript)=1057nt_BP=179nt
GGCGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCTGGGCCTCGAGCGCCCGCAGCCCACCTCTC
GGGGGCGGGCTCCCGGCGCTAGCAGGGCTGAAGAGAAGATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACAAGG
TGAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAGCCCGTGAGCGAGGTGGAGACTCGGGTGATAGCGTGCGATGGCGGCGGGGGAG
CTCTTGGCCACCCAAAAGTGTATATAAACTTGGACAAAGAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTTCAGACAGCACC
ACCACTAGAGCGTGTGGCACGCCGGGGGTCCCGCAGCATCCTGTGAGCATTTCCGCGGGGAAGCTGAGCACGTGAAGCTCGCTGGTTCTG
TGCGAAGGGTATTCCTGGTGCTGAATAAAGGGTGTTGCTGTCAAGGCTGACAATTTGTAAGTTTGTTTCTTTCATAGTCTGGGCTTTGGA
AGTGAACATCCACGTGGACATGGGTAGACATGCGAGTGGAAGCAGTGCCCGCTCCAGTGAGCCTGAGCTGCCTCCTGCCGGCCGCTGCCT
GCCTTACCGGCTGCTTCTGTGTGTCTCCTCTTATCCTTGGGGCCACGTGGGCTGCAGGAATGGGCGGGGGGCAGGGAAGGAGAAGGAGAA
GTGCCTCTTGTTTTGCAGATGCAACTGTGCTTCAGAGAGCCAAGGTGGGTCTTGAGGTGCATAGTGAAGGAGGGTGCCCAGGCCTCAACT
GGTCCTATGGGAAGGTCAGCCTCTCTCCTGTTGCTGGCTTGCAGAGCTGGTCTATCCGTCCGTCCTAGTCCCTATGTTGAAATGTCAGAT
CTTAAAACCCAAGAATTTAAGCACTGGTTTGAAGGCATCGAAAGTCACATACTGGCCACATTAAGGACAGTCTATGTTTTTAAAAGAGTA

>30784_30784_5_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370475_NDUFS6_chr5_1814452_ENST00000274137_length(amino acids)=126AA_BP=
MPALPAASVCLLLSLGPRGLQEWAGGREGEGEVPLVLQMQLCFREPRWVLRCIVKEGAQASTGPMGRSASLLLLACRAGLSVRPSPYVEM

--------------------------------------------------------------
>30784_30784_6_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370477_NDUFS6_chr5_1814452_ENST00000274137_length(transcript)=1146nt_BP=268nt
GGGCCGCCTCTGAGCGGGCGGCGGGCCGACGGCGAGCGCGGGCGGCGGCGGTGACGGAGGCGCCGCTGCCAGGGGGCGTGCGGCAGCGCG
GCGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCTGGGCCTCGAGCGCCCGCAGCCCACCTCTCG
GGGGCGGGCTCCCGGCGCTAGCAGGGCTGAAGAGAAGATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACAAGGT
GAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAGCCCGTGAGCGAGGTGGAGACTCGGGTGATAGCGTGCGATGGCGGCGGGGGAGC
TCTTGGCCACCCAAAAGTGTATATAAACTTGGACAAAGAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTTCAGACAGCACCA
CCACTAGAGCGTGTGGCACGCCGGGGGTCCCGCAGCATCCTGTGAGCATTTCCGCGGGGAAGCTGAGCACGTGAAGCTCGCTGGTTCTGT
GCGAAGGGTATTCCTGGTGCTGAATAAAGGGTGTTGCTGTCAAGGCTGACAATTTGTAAGTTTGTTTCTTTCATAGTCTGGGCTTTGGAA
GTGAACATCCACGTGGACATGGGTAGACATGCGAGTGGAAGCAGTGCCCGCTCCAGTGAGCCTGAGCTGCCTCCTGCCGGCCGCTGCCTG
CCTTACCGGCTGCTTCTGTGTGTCTCCTCTTATCCTTGGGGCCACGTGGGCTGCAGGAATGGGCGGGGGGCAGGGAAGGAGAAGGAGAAG
TGCCTCTTGTTTTGCAGATGCAACTGTGCTTCAGAGAGCCAAGGTGGGTCTTGAGGTGCATAGTGAAGGAGGGTGCCCAGGCCTCAACTG
GTCCTATGGGAAGGTCAGCCTCTCTCCTGTTGCTGGCTTGCAGAGCTGGTCTATCCGTCCGTCCTAGTCCCTATGTTGAAATGTCAGATC
TTAAAACCCAAGAATTTAAGCACTGGTTTGAAGGCATCGAAAGTCACATACTGGCCACATTAAGGACAGTCTATGTTTTTAAAAGAGTAA

>30784_30784_6_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000370477_NDUFS6_chr5_1814452_ENST00000274137_length(amino acids)=126AA_BP=
MPALPAASVCLLLSLGPRGLQEWAGGREGEGEVPLVLQMQLCFREPRWVLRCIVKEGAQASTGPMGRSASLLLLACRAGLSVRPSPYVEM

--------------------------------------------------------------
>30784_30784_7_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000439526_NDUFS6_chr5_1814452_ENST00000274137_length(transcript)=1057nt_BP=179nt
GGCGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCTGGGCCTCGAGCGCCCGCAGCCCACCTCTC
GGGGGCGGGCTCCCGGCGCTAGCAGGGCTGAAGAGAAGATGGAGGAGCTGGTGGTGGAAGTGCGGGGCTCCAATGGCGCTTTCTACAAGG
TGAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAGCCCGTGAGCGAGGTGGAGACTCGGGTGATAGCGTGCGATGGCGGCGGGGGAG
CTCTTGGCCACCCAAAAGTGTATATAAACTTGGACAAAGAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTTCAGACAGCACC
ACCACTAGAGCGTGTGGCACGCCGGGGGTCCCGCAGCATCCTGTGAGCATTTCCGCGGGGAAGCTGAGCACGTGAAGCTCGCTGGTTCTG
TGCGAAGGGTATTCCTGGTGCTGAATAAAGGGTGTTGCTGTCAAGGCTGACAATTTGTAAGTTTGTTTCTTTCATAGTCTGGGCTTTGGA
AGTGAACATCCACGTGGACATGGGTAGACATGCGAGTGGAAGCAGTGCCCGCTCCAGTGAGCCTGAGCTGCCTCCTGCCGGCCGCTGCCT
GCCTTACCGGCTGCTTCTGTGTGTCTCCTCTTATCCTTGGGGCCACGTGGGCTGCAGGAATGGGCGGGGGGCAGGGAAGGAGAAGGAGAA
GTGCCTCTTGTTTTGCAGATGCAACTGTGCTTCAGAGAGCCAAGGTGGGTCTTGAGGTGCATAGTGAAGGAGGGTGCCCAGGCCTCAACT
GGTCCTATGGGAAGGTCAGCCTCTCTCCTGTTGCTGGCTTGCAGAGCTGGTCTATCCGTCCGTCCTAGTCCCTATGTTGAAATGTCAGAT
CTTAAAACCCAAGAATTTAAGCACTGGTTTGAAGGCATCGAAAGTCACATACTGGCCACATTAAGGACAGTCTATGTTTTTAAAAGAGTA

>30784_30784_7_FMR1-NDUFS6_FMR1_chrX_146993748_ENST00000439526_NDUFS6_chr5_1814452_ENST00000274137_length(amino acids)=126AA_BP=
MPALPAASVCLLLSLGPRGLQEWAGGREGEGEVPLVLQMQLCFREPRWVLRCIVKEGAQASTGPMGRSASLLLLACRAGLSVRPSPYVEM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FMR1-NDUFS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFMR1chrX:146993748chr5:1814452ENST00000370470+117419_63217.0591.0RANBP9
HgeneFMR1chrX:146993748chr5:1814452ENST00000370475+117419_63217.0633.0RANBP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FMR1-NDUFS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FMR1-NDUFS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource