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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FNBP4-RTN3 (FusionGDB2 ID:30880)

Fusion Gene Summary for FNBP4-RTN3

check button Fusion gene summary
Fusion gene informationFusion gene name: FNBP4-RTN3
Fusion gene ID: 30880
HgeneTgene
Gene symbol

FNBP4

RTN3

Gene ID

23360

10313

Gene nameformin binding protein 4reticulon 3
SynonymsFBP30ASYIP|HAP|NSPL2|NSPLII|RTN3-A1
Cytomap

11p11.2

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionformin-binding protein 4formin-binding protein 30reticulon-3ASY interacting proteinNSP-like protein 2NSP-like protein IIhomolog of ASY proteinneuroendocrine-specific protein-like 2neuroendocrine-specific protein-like II
Modification date2020031320200327
UniProtAcc

Q8N3X1

.
Ensembl transtripts involved in fusion geneENST00000263773, ENST00000534003, 
ENST00000339997, ENST00000354497, 
ENST00000377819, ENST00000537981, 
ENST00000538995, ENST00000540798, 
ENST00000341307, ENST00000356000, 
Fusion gene scores* DoF score12 X 12 X 8=115214 X 8 X 8=896
# samples 1517
** MAII scorelog2(15/1152*10)=-2.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/896*10)=-2.3979639859199
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNBP4 [Title/Abstract] AND RTN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFNBP4(47786822)-RTN3(63517463), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRTN3

GO:0071787

endoplasmic reticulum tubular network formation

25612671


check buttonFusion gene breakpoints across FNBP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RTN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5813-01AFNBP4chr11

47786822

-RTN3chr11

63517463

+


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Fusion Gene ORF analysis for FNBP4-RTN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263773ENST00000339997FNBP4chr11

47786822

-RTN3chr11

63517463

+
5CDS-intronENST00000263773ENST00000354497FNBP4chr11

47786822

-RTN3chr11

63517463

+
5CDS-intronENST00000263773ENST00000377819FNBP4chr11

47786822

-RTN3chr11

63517463

+
5CDS-intronENST00000263773ENST00000537981FNBP4chr11

47786822

-RTN3chr11

63517463

+
5CDS-intronENST00000263773ENST00000538995FNBP4chr11

47786822

-RTN3chr11

63517463

+
5CDS-intronENST00000263773ENST00000540798FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-3CDSENST00000534003ENST00000341307FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-3CDSENST00000534003ENST00000356000FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-intronENST00000534003ENST00000339997FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-intronENST00000534003ENST00000354497FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-intronENST00000534003ENST00000377819FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-intronENST00000534003ENST00000537981FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-intronENST00000534003ENST00000538995FNBP4chr11

47786822

-RTN3chr11

63517463

+
5UTR-intronENST00000534003ENST00000540798FNBP4chr11

47786822

-RTN3chr11

63517463

+
In-frameENST00000263773ENST00000341307FNBP4chr11

47786822

-RTN3chr11

63517463

+
In-frameENST00000263773ENST00000356000FNBP4chr11

47786822

-RTN3chr11

63517463

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263773FNBP4chr1147786822-ENST00000341307RTN3chr1163517463+251732613909298
ENST00000263773FNBP4chr1147786822-ENST00000356000RTN3chr1163517463+255932613894293

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263773ENST00000341307FNBP4chr1147786822-RTN3chr1163517463+0.0008248250.99917513
ENST00000263773ENST00000356000FNBP4chr1147786822-RTN3chr1163517463+0.0009545430.99904543

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Fusion Genomic Features for FNBP4-RTN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FNBP4chr1147786821-RTN3chr1163517462+1.47E-081
FNBP4chr1147786821-RTN3chr1163517462+1.47E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FNBP4-RTN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:47786822/chr11:63517463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNBP4

Q8N3X1

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718844_10328241014.0DomainReticulon
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706844_103247242.0DomainReticulon
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704844_103247215.0DomainReticulon
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018844_103266256.0DomainReticulon
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929844_10328431033.0DomainReticulon
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107844_103247237.0DomainReticulon
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818844_1032731921.0DomainReticulon
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718864_8878241014.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718948_9688241014.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718973_9938241014.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706864_88747242.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706948_96847242.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706973_99347242.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704864_88747215.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704948_96847215.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704973_99347215.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018864_88766256.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018948_96866256.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018973_99366256.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929864_8878431033.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929948_9688431033.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929973_9938431033.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107864_88747237.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107948_96847237.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107973_99347237.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818864_887731921.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818948_968731921.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818973_993731921.0IntramembraneHelical
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718888_9478241014.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718969_9728241014.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718994_10328241014.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706888_94747242.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706969_97247242.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706994_103247242.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704888_94747215.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704969_97247215.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704994_103247215.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018888_94766256.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018969_97266256.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018994_103266256.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929888_9478431033.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929969_9728431033.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929994_10328431033.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107888_94747237.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107969_97247237.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107994_103247237.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818888_947731921.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818969_972731921.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818994_1032731921.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNBP4chr11:47786822chr11:63517463ENST00000263773-217630_6351041018.0Compositional biasNote=Poly-Glu
HgeneFNBP4chr11:47786822chr11:63517463ENST00000263773-217701_7311041018.0Compositional biasNote=Pro-rich
HgeneFNBP4chr11:47786822chr11:63517463ENST00000263773-217905_9251041018.0Compositional biasNote=Pro-rich
HgeneFNBP4chr11:47786822chr11:63517463ENST00000263773-217214_2481041018.0DomainWW 1
HgeneFNBP4chr11:47786822chr11:63517463ENST00000263773-217595_6291041018.0DomainWW 2
TgeneRTN3chr11:47786822chr11:63517463ENST00000339997182_8638241014.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST00000341307062_86347242.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST00000354497042_86347215.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST00000356000182_86366256.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST00000377819292_8638431033.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST00000537981072_86347237.0Topological domainCytoplasmic
TgeneRTN3chr11:47786822chr11:63517463ENST00000540798182_863731921.0Topological domainCytoplasmic


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Fusion Gene Sequence for FNBP4-RTN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30880_30880_1_FNBP4-RTN3_FNBP4_chr11_47786822_ENST00000263773_RTN3_chr11_63517463_ENST00000341307_length(transcript)=2517nt_BP=326nt
GCTTGGGCTCGCGATGGGGAAGAAGTCCCGGGCGGTACCCGGCCGTAGGCCCATCCTGCAACTCTCTCCGCCGGGTCCTCGGGGCAGCAC
GCCGGGCCGGGACCCGGAGCCGGAACCCGACACTGAGCCGGACTCAACCGCGGCGGTCCCCAGCCAGCCCGCCCCGTCGGCGGCGACGAC
CACCACCACCGCGGTGACTGCCGCCGCGGCCTCGGACGACTCGCCTTCAGAAGATGAACAGGAAGCGGTGCAGGAGGTTCCTAGAGTTGT
TCAGAATCCTCCAAAACCAGTCATGACCACTAGACCCACAGCTGTTAAAGCAACAGTGCACGATCTGATTTTCTGGAGAGATGTGAAGAA
GACTGGGTTTGTCTTTGGCACCACGCTGATCATGCTGCTTTCCCTGGCAGCTTTCAGTGTCATCAGTGTGGTTTCTTACCTCATCCTGGC
TCTTCTCTCTGTCACCATCAGCTTCAGGATCTACAAGTCCGTCATCCAAGCTGTACAGAAGTCAGAAGAAGGCCATCCATTCAAAGCCTA
CCTGGACGTAGACATTACTCTGTCCTCAGAAGCTTTCCATAATTACATGAATGCTGCCATGGTGCACATCAACAGGGCCCTGAAACTCAT
TATTCGTCTCTTTCTGGTAGAAGATCTGGTTGACTCCTTGAAGCTGGCTGTCTTCATGTGGCTGATGACCTATGTTGGTGCTGTTTTTAA
CGGAATCACCCTTCTAATTCTTGCTGAACTGCTCATTTTCAGTGTCCCGATTGTCTATGAGAAGTACAAGGATCCAAGCAAAACTCCCTG
GAATCGCCAAAAAAAAGGCAGAATAAGTACATGGAAACCAGAAATGCAACAGTTACTAAAACACCATTTAATAGTTATAACGTCGTTACT
TGTACTATGAAGGAAAATACTCAGTGTCAGCTTGAGCCTGCATTCCAAGCTTTTTTTTTAATTTGGTGTTTTCTCCCATCCTTTCCCTTT
AACCCTCAGTATCAAGCACAAAAATTGATGGACTGATAAAAGAACTATCTTAGAACTCAGAAGAAGAAAGAATCAAATTCATAGGATAAG
TCAATACCTTAATGGTGGTAGAGCCTTTACCTGTAGCTTGAAAGGGGAAAGATTGGAGGTAAGAGAGAAAATGAAAGAACACCTCTGGGT
CCTTCTGTCCAGTTTTCAGCACTAGTCTTACTCAGCTATCCATTATAGTTTTGCCCTTAAGAAGTCATGATTAACTTATGAAAAAATTAT
TTGGGGACAGGAGTGTGATACCTTCCTTGGTTTTTTTTTGCAGCCCTCAAATCCTATCTTCCTGCCCCACAATGTGAGCAGCTACCCCTG
ATACTCCTTTTCTTTAATGATTTAACTATCAACTTGATAAATAACTTATAGGTGATAGTGATAATTCCTGATTCCAAGAATGCCATCTGA
TAAAAAAGAATAGAAATGGAAAGTGGGACTGAGAGGGAGTCAGCAGGCATGCTGCGGTGGCGGTCACTCCCTCTGCCACTATCCCCAGGG
AAGGAAAGGCTCCGCCATTTGGGAAAGTGGTTTCTACGTCACTGGACACCGGTTCTGAGCATTAGTTTGAGAACTCGTTCCCGAATGTGC
TTTCCTCCCTCTCCCCTGCCCACCTCAAGTTTAATAAATAAGGTTGTACTTTTCTTACTATAAAATAAATGTCTGTAACTGCTGTGCACT
GCTGTAAACTTGTTAGAGAAAAAAATAACCTGCATGTGGGCTCCTCAGTTATTGAGTTTTTGTGATCCTATCTCAGTCTGGGGGGGAACA
TTCTCAAGAGGTGAAATACAGAAAGCCTTTTTTTCTTGATCTTTTCCCGAGATTCAAATCTCCGATTCCCATTTGGGGGCAAGTTTTTTT
CTTCACCTTCAATATGAGAATTCAGCGAACTTGAAAGAAAAATCATCTGTGAGTTCCTTCAGGTTCTCACTCATAGTCATGATCCTTCAG
AGGGAATATGCACTGGCGAGTTTAAAGTAAGGGCTATGATATTTGATGGTCCCAAAGTACGGCAGCTGCAAAAAGTAGTGGAAGGAAATT
GTCTACGTGTCTTGGAAAAATTAGTTAGGAATTTGGATGGGTAAAAGGTACCCTTGCCTTACTCCATCTTATTTTCTTAGCCCCCTTTGA
GTGTTTTAACTGGTTTCATGTCCTAGTAGGAAGTGCATTCTCCATCCTCATCCTCTGCCCTCCCAGGAAGTCAGTGATTGTCTTTTTGGG
CTTCCCCTCCAAAGGACCTTCTGCAGTGGAAGTGCCACATCCAGTTCTTTTCTTTTGTTGCTGCTGTGTTTAGATAATTGAAGAGATCTT
TGTGCCACACAGGATTTTTTTTTTTTTTTAAGAAAAACCTATAGATGAAAAATTACTAATGAAACTGTGTGTACGTGTCTGTGCGTGCAA

>30880_30880_1_FNBP4-RTN3_FNBP4_chr11_47786822_ENST00000263773_RTN3_chr11_63517463_ENST00000341307_length(amino acids)=298AA_BP=104
MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAASDDSPSEDEQEAVQEVPRVVQNPP
KPVMTTRPTAVKATVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVD
ITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKDPSKTPWNRQK

--------------------------------------------------------------
>30880_30880_2_FNBP4-RTN3_FNBP4_chr11_47786822_ENST00000263773_RTN3_chr11_63517463_ENST00000356000_length(transcript)=2559nt_BP=326nt
GCTTGGGCTCGCGATGGGGAAGAAGTCCCGGGCGGTACCCGGCCGTAGGCCCATCCTGCAACTCTCTCCGCCGGGTCCTCGGGGCAGCAC
GCCGGGCCGGGACCCGGAGCCGGAACCCGACACTGAGCCGGACTCAACCGCGGCGGTCCCCAGCCAGCCCGCCCCGTCGGCGGCGACGAC
CACCACCACCGCGGTGACTGCCGCCGCGGCCTCGGACGACTCGCCTTCAGAAGATGAACAGGAAGCGGTGCAGGAGGTTCCTAGAGTTGT
TCAGAATCCTCCAAAACCAGTCATGACCACTAGACCCACAGCTGTTAAAGCAACAGTGCACGATCTGATTTTCTGGAGAGATGTGAAGAA
GACTGGGTTTGTCTTTGGCACCACGCTGATCATGCTGCTTTCCCTGGCAGCTTTCAGTGTCATCAGTGTGGTTTCTTACCTCATCCTGGC
TCTTCTCTCTGTCACCATCAGCTTCAGGATCTACAAGTCCGTCATCCAAGCTGTACAGAAGTCAGAAGAAGGCCATCCATTCAAAGCCTA
CCTGGACGTAGACATTACTCTGTCCTCAGAAGCTTTCCATAATTACATGAATGCTGCCATGGTGCACATCAACAGGGCCCTGAAACTCAT
TATTCGTCTCTTTCTGGTAGAAGATCTGGTTGACTCCTTGAAGCTGGCTGTCTTCATGTGGCTGATGACCTATGTTGGTGCTGTTTTTAA
CGGAATCACCCTTCTAATTCTTGCTGAACTGCTCATTTTCAGTGTCCCGATTGTCTATGAGAAGTACAAGACCCAGATTGATCACTATGT
TGGCATCGCCCGAGATCAGACCAAGTCAATTGTTGAAAAGATCCAAGCAAAACTCCCTGGAATCGCCAAAAAAAAGGCAGAATAAGTACA
TGGAAACCAGAAATGCAACAGTTACTAAAACACCATTTAATAGTTATAACGTCGTTACTTGTACTATGAAGGAAAATACTCAGTGTCAGC
TTGAGCCTGCATTCCAAGCTTTTTTTTTAATTTGGTGTTTTCTCCCATCCTTTCCCTTTAACCCTCAGTATCAAGCACAAAAATTGATGG
ACTGATAAAAGAACTATCTTAGAACTCAGAAGAAGAAAGAATCAAATTCATAGGATAAGTCAATACCTTAATGGTGGTAGAGCCTTTACC
TGTAGCTTGAAAGGGGAAAGATTGGAGGTAAGAGAGAAAATGAAAGAACACCTCTGGGTCCTTCTGTCCAGTTTTCAGCACTAGTCTTAC
TCAGCTATCCATTATAGTTTTGCCCTTAAGAAGTCATGATTAACTTATGAAAAAATTATTTGGGGACAGGAGTGTGATACCTTCCTTGGT
TTTTTTTTGCAGCCCTCAAATCCTATCTTCCTGCCCCACAATGTGAGCAGCTACCCCTGATACTCCTTTTCTTTAATGATTTAACTATCA
ACTTGATAAATAACTTATAGGTGATAGTGATAATTCCTGATTCCAAGAATGCCATCTGATAAAAAAGAATAGAAATGGAAAGTGGGACTG
AGAGGGAGTCAGCAGGCATGCTGCGGTGGCGGTCACTCCCTCTGCCACTATCCCCAGGGAAGGAAAGGCTCCGCCATTTGGGAAAGTGGT
TTCTACGTCACTGGACACCGGTTCTGAGCATTAGTTTGAGAACTCGTTCCCGAATGTGCTTTCCTCCCTCTCCCCTGCCCACCTCAAGTT
TAATAAATAAGGTTGTACTTTTCTTACTATAAAATAAATGTCTGTAACTGCTGTGCACTGCTGTAAACTTGTTAGAGAAAAAAATAACCT
GCATGTGGGCTCCTCAGTTATTGAGTTTTTGTGATCCTATCTCAGTCTGGGGGGGAACATTCTCAAGAGGTGAAATACAGAAAGCCTTTT
TTTCTTGATCTTTTCCCGAGATTCAAATCTCCGATTCCCATTTGGGGGCAAGTTTTTTTCTTCACCTTCAATATGAGAATTCAGCGAACT
TGAAAGAAAAATCATCTGTGAGTTCCTTCAGGTTCTCACTCATAGTCATGATCCTTCAGAGGGAATATGCACTGGCGAGTTTAAAGTAAG
GGCTATGATATTTGATGGTCCCAAAGTACGGCAGCTGCAAAAAGTAGTGGAAGGAAATTGTCTACGTGTCTTGGAAAAATTAGTTAGGAA
TTTGGATGGGTAAAAGGTACCCTTGCCTTACTCCATCTTATTTTCTTAGCCCCCTTTGAGTGTTTTAACTGGTTTCATGTCCTAGTAGGA
AGTGCATTCTCCATCCTCATCCTCTGCCCTCCCAGGAAGTCAGTGATTGTCTTTTTGGGCTTCCCCTCCAAAGGACCTTCTGCAGTGGAA
GTGCCACATCCAGTTCTTTTCTTTTGTTGCTGCTGTGTTTAGATAATTGAAGAGATCTTTGTGCCACACAGGATTTTTTTTTTTTTTTAA
GAAAAACCTATAGATGAAAAATTACTAATGAAACTGTGTGTACGTGTCTGTGCGTGCAACATAAAAATACAGTAGCACCTAAGGAGCTTG

>30880_30880_2_FNBP4-RTN3_FNBP4_chr11_47786822_ENST00000263773_RTN3_chr11_63517463_ENST00000356000_length(amino acids)=293AA_BP=104
MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAASDDSPSEDEQEAVQEVPRVVQNPP
KPVMTTRPTAVKATVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVD
ITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIAR

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Fusion Gene PPI Analysis for FNBP4-RTN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRTN3chr11:47786822chr11:63517463ENST00000339997181000_1002824.33333333333341014.0BACE1
TgeneRTN3chr11:47786822chr11:63517463ENST00000341307061000_100247.333333333333336242.0BACE1
TgeneRTN3chr11:47786822chr11:63517463ENST00000354497041000_100247.333333333333336215.0BACE1
TgeneRTN3chr11:47786822chr11:63517463ENST00000356000181000_100266.33333333333333256.0BACE1
TgeneRTN3chr11:47786822chr11:63517463ENST00000377819291000_1002843.33333333333341033.0BACE1
TgeneRTN3chr11:47786822chr11:63517463ENST00000537981071000_100247.333333333333336237.0BACE1
TgeneRTN3chr11:47786822chr11:63517463ENST00000540798181000_1002731.3333333333334921.0BACE1
TgeneRTN3chr11:47786822chr11:63517463ENST0000033999718987_1032824.33333333333341014.0FADD
TgeneRTN3chr11:47786822chr11:63517463ENST0000034130706987_103247.333333333333336242.0FADD
TgeneRTN3chr11:47786822chr11:63517463ENST0000035449704987_103247.333333333333336215.0FADD
TgeneRTN3chr11:47786822chr11:63517463ENST0000035600018987_103266.33333333333333256.0FADD
TgeneRTN3chr11:47786822chr11:63517463ENST0000037781929987_1032843.33333333333341033.0FADD
TgeneRTN3chr11:47786822chr11:63517463ENST0000053798107987_103247.333333333333336237.0FADD
TgeneRTN3chr11:47786822chr11:63517463ENST0000054079818987_1032731.3333333333334921.0FADD


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FNBP4-RTN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FNBP4-RTN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource