Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FNDC3A-ITM2B (FusionGDB2 ID:30895)

Fusion Gene Summary for FNDC3A-ITM2B

Fusion gene summary

Fusion gene information	Fusion gene name: FNDC3A-ITM2B
	Fusion gene ID: 30895
		Hgene	Tgene
	Gene symbol	FNDC3A	ITM2B
	Gene ID	22862	9445
	Gene name	fibronectin type III domain containing 3A	integral membrane protein 2B
	Synonyms	FNDC3\|HUGO\|bA203I16.1\|bA203I16.5	ABRI\|BRI\|BRI2\|BRICD2B\|E25B\|E3-16\|FBD\|RDGCA\|imBRI2
	Cytomap	13q14.2	13q14.2
	Type of gene	protein-coding	protein-coding
	Description	fibronectin type-III domain-containing protein 3Ahuman gene expressed in odontoblasts	integral membrane protein 2BABri/ADan amyloid peptideBRICHOS domain containing 2Bepididymis secretory sperm binding proteinimmature BRI2transmembrane protein BRI
	Modification date	20200313	20200313
	UniProtAcc	Q9Y2H6	Q9Y287
	Ensembl transtripts involved in fusion gene	ENST00000492622, ENST00000541916, ENST00000398316,	ENST00000378549, ENST00000378565,
Fusion gene scores	* DoF score	15 X 12 X 7=1260	19 X 11 X 7=1463
	# samples	16	22
	** MAII score	log2(16/1260*10)=-2.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/1463*10)=-2.73335434061383 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FNDC3A [Title/Abstract] AND ITM2B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FNDC3A(49580425)-ITM2B(48827943), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ITM2B	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	16027166\|18524908

Fusion gene breakpoints across FNDC3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITM2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-VR-AA7D	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+
ChimerDB4	STAD	TCGA-B7-A5TJ	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+

Top

Fusion Gene ORF analysis for FNDC3A-ITM2B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000492622	ENST00000378549	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+
In-frame	ENST00000492622	ENST00000378565	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+
In-frame	ENST00000541916	ENST00000378549	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+
In-frame	ENST00000541916	ENST00000378565	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+
intron-3CDS	ENST00000398316	ENST00000378549	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+
intron-3CDS	ENST00000398316	ENST00000378565	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000492622

FNDC3A

chr13

49580425

ENST00000378565

ITM2B

chr13

48827943

2188

404

299

1087

262

ENST00000492622

FNDC3A

chr13

49580425

ENST00000378549

ITM2B

chr13

48827943

934

404

299

769

156

ENST00000541916

FNDC3A

chr13

49580425

ENST00000378565

ITM2B

chr13

48827943

1956

172

855

262

ENST00000541916

FNDC3A

chr13

49580425

ENST00000378549

ITM2B

chr13

48827943

702

172

537

156

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000492622	ENST00000378565	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	0.000241868	0.9997582
ENST00000492622	ENST00000378549	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	0.002736085	0.9972639
ENST00000541916	ENST00000378565	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	0.00018463	0.9998154
ENST00000541916	ENST00000378549	FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	0.001269591	0.99873036

Top

Fusion Genomic Features for FNDC3A-ITM2B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	1.06E-05	0.9999894
FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	1.06E-05	0.9999894
FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	1.06E-05	0.9999894
FNDC3A	chr13	49580425	+	ITM2B	chr13	48827943	+	1.06E-05	0.9999894

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FNDC3A-ITM2B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:49580425/chr13:48827943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FNDC3A Q9Y2H6	ITM2B Q9Y287
FUNCTION: Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}.	FUNCTION: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITM2B

chr13:49580425

chr13:48827943

ENST00000378565

137_231

267.0

Domain

BRICHOS

Tgene

ITM2B

chr13:49580425

chr13:48827943

ENST00000378565

76_266

267.0

Topological domain

Lumenal

Tgene

ITM2B

chr13:49580425

chr13:48827943

ENST00000378565

55_75

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

68_133

1143.0

Compositional bias

Note=Pro-rich

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

68_133

1199.0

Compositional bias

Note=Pro-rich

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

68_133

1199.0

Compositional bias

Note=Pro-rich

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

1046_1151

1143.0

Domain

Fibronectin type-III 9

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

268_369

1143.0

Domain

Fibronectin type-III 1

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

373_465

1143.0

Domain

Fibronectin type-III 2

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

469_562

1143.0

Domain

Fibronectin type-III 3

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

566_660

1143.0

Domain

Fibronectin type-III 4

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

664_757

1143.0

Domain

Fibronectin type-III 5

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

761_851

1143.0

Domain

Fibronectin type-III 6

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

861_950

1143.0

Domain

Fibronectin type-III 7

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

951_1045

1143.0

Domain

Fibronectin type-III 8

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

1046_1151

1199.0

Domain

Fibronectin type-III 9

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

268_369

1199.0

Domain

Fibronectin type-III 1

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

373_465

1199.0

Domain

Fibronectin type-III 2

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

469_562

1199.0

Domain

Fibronectin type-III 3

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

566_660

1199.0

Domain

Fibronectin type-III 4

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

664_757

1199.0

Domain

Fibronectin type-III 5

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

761_851

1199.0

Domain

Fibronectin type-III 6

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

861_950

1199.0

Domain

Fibronectin type-III 7

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

951_1045

1199.0

Domain

Fibronectin type-III 8

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

1046_1151

1199.0

Domain

Fibronectin type-III 9

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

268_369

1199.0

Domain

Fibronectin type-III 1

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

373_465

1199.0

Domain

Fibronectin type-III 2

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

469_562

1199.0

Domain

Fibronectin type-III 3

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

566_660

1199.0

Domain

Fibronectin type-III 4

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

664_757

1199.0

Domain

Fibronectin type-III 5

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

761_851

1199.0

Domain

Fibronectin type-III 6

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

861_950

1199.0

Domain

Fibronectin type-III 7

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

951_1045

1199.0

Domain

Fibronectin type-III 8

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000398316

1177_1197

1143.0

Transmembrane

Helical

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000492622

1177_1197

1199.0

Transmembrane

Helical

Hgene

FNDC3A

chr13:49580425

chr13:48827943

ENST00000541916

1177_1197

1199.0

Transmembrane

Helical

Tgene

ITM2B

chr13:49580425

chr13:48827943

ENST00000378565

1_54

267.0

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for FNDC3A-ITM2B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>30895_30895_1_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000492622_ITM2B_chr13_48827943_ENST00000378549_length(transcript)=934nt_BP=404nt
CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG
AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC
AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT
GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT
CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTT
GGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAA
CCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATC
GACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAA
TTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACA
GCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCA

>30895_30895_1_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000492622_ITM2B_chr13_48827943_ENST00000378549_length(amino acids)=156AA_BP=35
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIH

--------------------------------------------------------------
>30895_30895_2_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000492622_ITM2B_chr13_48827943_ENST00000378565_length(transcript)=2188nt_BP=404nt
CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG
AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC
AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT
GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT
CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTT
GGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATG
ACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAA
TTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACA
TTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTA
TGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTA
TTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAG
AAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTT
GTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTT
AAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTC
TTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATT
ACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCA
TACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTT
TCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGG
CATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAA
TATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAG
AGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAA
TAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAA
AATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCA
CAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAA

>30895_30895_2_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000492622_ITM2B_chr13_48827943_ENST00000378565_length(amino acids)=262AA_BP=35
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYI
KDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELL

--------------------------------------------------------------
>30895_30895_3_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000541916_ITM2B_chr13_48827943_ENST00000378549_length(transcript)=702nt_BP=172nt
TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC
ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGACCCAGA
TGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGG
AGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCG
CATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAA
AGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAAC
AGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCT

>30895_30895_3_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000541916_ITM2B_chr13_48827943_ENST00000378549_length(amino acids)=156AA_BP=35
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIH

--------------------------------------------------------------
>30895_30895_4_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000541916_ITM2B_chr13_48827943_ENST00000378565_length(transcript)=1956nt_BP=172nt
TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC
ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGACCCAGA
TGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGG
AGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGA
GCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGT
GCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGA
TAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTA
TTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACT
GTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCG
GCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCAT
AACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTC
ATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATA
GATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCA
AGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTA
CCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTT
AGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTG
TGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATA
ATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATA
CAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAAC
ATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAA
CGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGC

>30895_30895_4_FNDC3A-ITM2B_FNDC3A_chr13_49580425_ENST00000541916_ITM2B_chr13_48827943_ENST00000378565_length(amino acids)=262AA_BP=35
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYI
KDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FNDC3A-ITM2B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FNDC3A-ITM2B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FNDC3A-ITM2B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source