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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FNDC3A-RPS29 (FusionGDB2 ID:30904)

Fusion Gene Summary for FNDC3A-RPS29

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3A-RPS29
Fusion gene ID: 30904
HgeneTgene
Gene symbol

FNDC3A

RPS29

Gene ID

22862

6235

Gene namefibronectin type III domain containing 3Aribosomal protein S29
SynonymsFNDC3|HUGO|bA203I16.1|bA203I16.5DBA13|S29|uS14
Cytomap

13q14.2

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type-III domain-containing protein 3Ahuman gene expressed in odontoblasts40S ribosomal protein S29small ribosomal subunit protein uS14
Modification date2020031320200313
UniProtAcc

Q9Y2H6

.
Ensembl transtripts involved in fusion geneENST00000398316, ENST00000492622, 
ENST00000541916, 		ENST00000557111, 
ENST00000245458, ENST00000396020, 
Fusion gene scores* DoF score15 X 12 X 7=126016 X 14 X 5=1120
# samples 1617
** MAII scorelog2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1120*10)=-2.71989208080726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNDC3A [Title/Abstract] AND RPS29 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFNDC3A(49720071)-RPS29(50052767), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPS29

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across FNDC3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS29 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KTFNDC3Achr13

49720071

+RPS29chr14

50052767

-


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Fusion Gene ORF analysis for FNDC3A-RPS29

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000398316ENST00000557111FNDC3Achr13

49720071

+RPS29chr14

50052767

-
5CDS-5UTRENST00000492622ENST00000557111FNDC3Achr13

49720071

+RPS29chr14

50052767

-
5CDS-5UTRENST00000541916ENST00000557111FNDC3Achr13

49720071

+RPS29chr14

50052767

-
In-frameENST00000398316ENST00000245458FNDC3Achr13

49720071

+RPS29chr14

50052767

-
In-frameENST00000398316ENST00000396020FNDC3Achr13

49720071

+RPS29chr14

50052767

-
In-frameENST00000492622ENST00000245458FNDC3Achr13

49720071

+RPS29chr14

50052767

-
In-frameENST00000492622ENST00000396020FNDC3Achr13

49720071

+RPS29chr14

50052767

-
In-frameENST00000541916ENST00000245458FNDC3Achr13

49720071

+RPS29chr14

50052767

-
In-frameENST00000541916ENST00000396020FNDC3Achr13

49720071

+RPS29chr14

50052767

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000492622FNDC3Achr1349720071+ENST00000396020RPS29chr1450052767-256412822991423374
ENST00000492622FNDC3Achr1349720071+ENST00000245458RPS29chr1450052767-148612822991390363
ENST00000541916FNDC3Achr1349720071+ENST00000396020RPS29chr1450052767-23321050671191374
ENST00000541916FNDC3Achr1349720071+ENST00000245458RPS29chr1450052767-12541050671158363
ENST00000398316FNDC3Achr1349720071+ENST00000396020RPS29chr1450052767-2178896451037330
ENST00000398316FNDC3Achr1349720071+ENST00000245458RPS29chr1450052767-1100896451004319

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000492622ENST00000396020FNDC3Achr1349720071+RPS29chr1450052767-0.0002939960.999706
ENST00000492622ENST00000245458FNDC3Achr1349720071+RPS29chr1450052767-0.0003441620.99965584
ENST00000541916ENST00000396020FNDC3Achr1349720071+RPS29chr1450052767-0.0002029260.99979705
ENST00000541916ENST00000245458FNDC3Achr1349720071+RPS29chr1450052767-0.0001377320.9998622
ENST00000398316ENST00000396020FNDC3Achr1349720071+RPS29chr1450052767-0.0003958080.99960417
ENST00000398316ENST00000245458FNDC3Achr1349720071+RPS29chr1450052767-0.0002055910.9997944

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Fusion Genomic Features for FNDC3A-RPS29


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FNDC3A-RPS29


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:49720071/chr14:50052767)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3A

Q9Y2H6

.
FUNCTION: Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+62468_1332691143.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+82668_1333251199.0Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+82668_1333251199.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+6241046_11512691143.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624268_3692691143.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624373_4652691143.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624469_5622691143.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624566_6602691143.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624664_7572691143.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624761_8512691143.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624861_9502691143.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+624951_10452691143.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+8261046_11513251199.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826268_3693251199.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826373_4653251199.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826469_5623251199.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826566_6603251199.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826664_7573251199.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826761_8513251199.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826861_9503251199.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+826951_10453251199.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+8261046_11513251199.0DomainFibronectin type-III 9
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826268_3693251199.0DomainFibronectin type-III 1
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826373_4653251199.0DomainFibronectin type-III 2
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826469_5623251199.0DomainFibronectin type-III 3
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826566_6603251199.0DomainFibronectin type-III 4
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826664_7573251199.0DomainFibronectin type-III 5
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826761_8513251199.0DomainFibronectin type-III 6
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826861_9503251199.0DomainFibronectin type-III 7
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+826951_10453251199.0DomainFibronectin type-III 8
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000398316+6241177_11972691143.0TransmembraneHelical
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000492622+8261177_11973251199.0TransmembraneHelical
HgeneFNDC3Achr13:49720071chr14:50052767ENST00000541916+8261177_11973251199.0TransmembraneHelical


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Fusion Gene Sequence for FNDC3A-RPS29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30904_30904_1_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000398316_RPS29_chr14_50052767_ENST00000245458_length(transcript)=1100nt_BP=896nt
AGCCGTTCTCCAATTAAAGCTGTTAACGTGTACTACGCTGTTTCCTTGTTGGATTTTCTTGTTCTCTGCTGCTACTGTAAAAACGAAATG
AGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGGTTATTGAA
GACAATGGTGTTCGAAGAGTTGTCGTGGTCCCTCAGGCACCAGAGTTTCACCCTGGTAGTCACACAGTTCTCCACCGTTCTCCACATCCT
CCTCTACCTGGTTTCATTCCTGTCCCAACTATGATGCCGCCTCCACCACGTCATATGTACTCACCCGTGACTGGAGCTGGAGACATGACA
ACACAGTATATGCCACAGTATCAGTCTTCACAAGTCTATGGAGATGTAGATGCTCACTCTACACATGGAAGGTCCAACTTTAGAGATGAA
CGATCTAGTAAAACATATGAACGTTTGCAGAAAAAATTGAAGGATCGCCAAGGAACACAGAAAGATAAAATGAGCAGTCCACCATCATCA
CCCCAGAAATGCCCTTCTCCCATTAATGAACATAATGGACTTATAAAAGGACAAATTGCTGGTGGTATAAACACAGGATCAGCAAAAATC
AAGTCTGGGAAGGGGAAAGGTGGTACACAAGTTGATACAGAAATTGAAGAAAAAGATGAAGAAACTAAAGCATTTGAAGCACTTCTTTCC
AACATTGTCAAACCAGTGGCCTCCGACATCCAGGCAAGGACAGTAGTACTTACCTGGTCACCACCTTCCAGCCTCATTAATGGTGAAACA
GATGAAAGTAGTGTACCAGAGCTCTATGGTTATGAAGTTCTGATCTCAAGTACTGGAAAAGATGGGAAATACAAAAGTGTATATGTTCGT
GTCTGTTCAAACCGGCACGGTCTGATCCGGAAATATGGCCTCAATATGTGCCGCCAGTGTTTCCGTCAGTACGCGAAGGATATCGGTTTC
ATTAAGTTGGACTAAATGCTCTTCCTTCAGAGGATTATCCGGGGCATCTACTCAATGAAAAACCATGATAATTCTTTGTATATAAAATAA

>30904_30904_1_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000398316_RPS29_chr14_50052767_ENST00000245458_length(amino acids)=319AA_BP=282
MLDFLVLCCYCKNEMSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVPTMMPPP
PRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLI
KGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLI

--------------------------------------------------------------
>30904_30904_2_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000398316_RPS29_chr14_50052767_ENST00000396020_length(transcript)=2178nt_BP=896nt
AGCCGTTCTCCAATTAAAGCTGTTAACGTGTACTACGCTGTTTCCTTGTTGGATTTTCTTGTTCTCTGCTGCTACTGTAAAAACGAAATG
AGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGGTTATTGAA
GACAATGGTGTTCGAAGAGTTGTCGTGGTCCCTCAGGCACCAGAGTTTCACCCTGGTAGTCACACAGTTCTCCACCGTTCTCCACATCCT
CCTCTACCTGGTTTCATTCCTGTCCCAACTATGATGCCGCCTCCACCACGTCATATGTACTCACCCGTGACTGGAGCTGGAGACATGACA
ACACAGTATATGCCACAGTATCAGTCTTCACAAGTCTATGGAGATGTAGATGCTCACTCTACACATGGAAGGTCCAACTTTAGAGATGAA
CGATCTAGTAAAACATATGAACGTTTGCAGAAAAAATTGAAGGATCGCCAAGGAACACAGAAAGATAAAATGAGCAGTCCACCATCATCA
CCCCAGAAATGCCCTTCTCCCATTAATGAACATAATGGACTTATAAAAGGACAAATTGCTGGTGGTATAAACACAGGATCAGCAAAAATC
AAGTCTGGGAAGGGGAAAGGTGGTACACAAGTTGATACAGAAATTGAAGAAAAAGATGAAGAAACTAAAGCATTTGAAGCACTTCTTTCC
AACATTGTCAAACCAGTGGCCTCCGACATCCAGGCAAGGACAGTAGTACTTACCTGGTCACCACCTTCCAGCCTCATTAATGGTGAAACA
GATGAAAGTAGTGTACCAGAGCTCTATGGTTATGAAGTTCTGATCTCAAGTACTGGAAAAGATGGGAAATACAAAAGTGTATATGTTCGT
GTCTGTTCAAACCGGCACGGTCTGATCCGGAAATATGGCCTCAATATGTGCCGCCAGTGTTTCCGTCAGTACGCGAAGGATATCGGTTTC
ATTAAGAAAGACCTGAGCTGTCTTCCTTGGCACTGCCTATGGAGGTGACACCCATCTCCTCCATCATGGCCATCCTGAGACCGCTCGCGA
AGCCCAAGATCATCAAAAAGAGCACCAAGTTCACTGGGAACCAGTCAGACTGATATGTCAAAATTAAGGGTAACTGGTGGAAACACAGAG
GTATTAACAACAGGGTTCATAGAAGGTTTGAGGGCCAGATCTATGCCCAACATTGGTTATGGGAGAAACAAAAAGACAAAGCACATACTG
CCCAGTGGCTTCTGGAAGTTCCTGGTCCACAACGTTAAGGAGCTGGAAGTACTGCTGGTGAGCAACAAATCTTACTGTGTTGAGATCACT
CATGATGTTTCTTCCAAGAACTGCAAAGCCATCTTGGAAAGAGCAGCCCAGGTGGTCATCAGAGTCACCAATGCCAATGCCAGCCTGCAC
AGTGCAGAAAGTGAATAGACAGTGAATGTGTTTGTTTTATTGGGGTTTAAATAAAACCAATAAAACTGTAAAAACAAAAACAACAAAAAC
CAGAGACCCTGGCTTTTGGACAGTTGTTCGTGTGGCTAATGCCCCCAACAGTTTTATTTTTTAAAATTTTATTTATGTATTGTTTTTGAG
ATGAAGTCTTCCTCTGACTGGAGTGCAGTGATGCAAGCTCAGCTCTCTGCAACTTCCACCTCCCAGGTTCAAGTGATTCTTCTGTCTCAG
CCTCCCAAGTGGCTGGGATTACAGGTGCCCACTACCACACCTGACTAATTTTTGTATTTTTGTAGAGATGGGGTTTCATCCTCTTGGCCA
GGCTGGTTTCGAACTCCTGACCTCAAGGGATCCTCCCACCTCAGCTTCCCAAAGTGCTGGGATCACAGGCTTGTATTAGTTCATTTTCAC
ACTGCTGATAAAGACATACCTAAGACTGGGAAGAAAAATAGGTTTATTGGACTCACAGTTCCATGTGGCTGGGGATGCCTCACAATTATG
GTAGAAGGCAAAAGGCACTTCTTAGATGGCAGCGGCAAGCAGGAAATGAGGAAGACATGAAAGCAGATATCCCTTATAAAACCATCAGTT
CTCGTGATACTTACTCACTACCATGAGAAAGTATGGGGGAAACCGCTCCCATGATTCAGTTATCTCCCACCGGGTCCCTCTCACAACATG

>30904_30904_2_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000398316_RPS29_chr14_50052767_ENST00000396020_length(amino acids)=330AA_BP=282
MLDFLVLCCYCKNEMSGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVPTMMPPP
PRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLI
KGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLI

--------------------------------------------------------------
>30904_30904_3_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000492622_RPS29_chr14_50052767_ENST00000245458_length(transcript)=1486nt_BP=1282nt
CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG
AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC
AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT
GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT
CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAA
GAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTC
CTGGATATGCCCCACAGGTTATTGAAGACAATGGTGTTCGAAGAGTTGTCGTGGTCCCTCAGGCACCAGAGTTTCACCCTGGTAGTCACA
CAGTTCTCCACCGTTCTCCACATCCTCCTCTACCTGGTTTCATTCCTGTCCCAACTATGATGCCGCCTCCACCACGTCATATGTACTCAC
CCGTGACTGGAGCTGGAGACATGACAACACAGTATATGCCACAGTATCAGTCTTCACAAGTCTATGGAGATGTAGATGCTCACTCTACAC
ATGGAAGGTCCAACTTTAGAGATGAACGATCTAGTAAAACATATGAACGTTTGCAGAAAAAATTGAAGGATCGCCAAGGAACACAGAAAG
ATAAAATGAGCAGTCCACCATCATCACCCCAGAAATGCCCTTCTCCCATTAATGAACATAATGGACTTATAAAAGGACAAATTGCTGGTG
GTATAAACACAGGATCAGCAAAAATCAAGTCTGGGAAGGGGAAAGGTGGTACACAAGTTGATACAGAAATTGAAGAAAAAGATGAAGAAA
CTAAAGCATTTGAAGCACTTCTTTCCAACATTGTCAAACCAGTGGCCTCCGACATCCAGGCAAGGACAGTAGTACTTACCTGGTCACCAC
CTTCCAGCCTCATTAATGGTGAAACAGATGAAAGTAGTGTACCAGAGCTCTATGGTTATGAAGTTCTGATCTCAAGTACTGGAAAAGATG
GGAAATACAAAAGTGTATATGTTCGTGTCTGTTCAAACCGGCACGGTCTGATCCGGAAATATGGCCTCAATATGTGCCGCCAGTGTTTCC
GTCAGTACGCGAAGGATATCGGTTTCATTAAGTTGGACTAAATGCTCTTCCTTCAGAGGATTATCCGGGGCATCTACTCAATGAAAAACC

>30904_30904_3_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000492622_RPS29_chr14_50052767_ENST00000245458_length(amino acids)=363AA_BP=326
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIED
NGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDER
SSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSN
IVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFI

--------------------------------------------------------------
>30904_30904_4_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000492622_RPS29_chr14_50052767_ENST00000396020_length(transcript)=2564nt_BP=1282nt
CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG
AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC
AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT
GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT
CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAA
GAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTC
CTGGATATGCCCCACAGGTTATTGAAGACAATGGTGTTCGAAGAGTTGTCGTGGTCCCTCAGGCACCAGAGTTTCACCCTGGTAGTCACA
CAGTTCTCCACCGTTCTCCACATCCTCCTCTACCTGGTTTCATTCCTGTCCCAACTATGATGCCGCCTCCACCACGTCATATGTACTCAC
CCGTGACTGGAGCTGGAGACATGACAACACAGTATATGCCACAGTATCAGTCTTCACAAGTCTATGGAGATGTAGATGCTCACTCTACAC
ATGGAAGGTCCAACTTTAGAGATGAACGATCTAGTAAAACATATGAACGTTTGCAGAAAAAATTGAAGGATCGCCAAGGAACACAGAAAG
ATAAAATGAGCAGTCCACCATCATCACCCCAGAAATGCCCTTCTCCCATTAATGAACATAATGGACTTATAAAAGGACAAATTGCTGGTG
GTATAAACACAGGATCAGCAAAAATCAAGTCTGGGAAGGGGAAAGGTGGTACACAAGTTGATACAGAAATTGAAGAAAAAGATGAAGAAA
CTAAAGCATTTGAAGCACTTCTTTCCAACATTGTCAAACCAGTGGCCTCCGACATCCAGGCAAGGACAGTAGTACTTACCTGGTCACCAC
CTTCCAGCCTCATTAATGGTGAAACAGATGAAAGTAGTGTACCAGAGCTCTATGGTTATGAAGTTCTGATCTCAAGTACTGGAAAAGATG
GGAAATACAAAAGTGTATATGTTCGTGTCTGTTCAAACCGGCACGGTCTGATCCGGAAATATGGCCTCAATATGTGCCGCCAGTGTTTCC
GTCAGTACGCGAAGGATATCGGTTTCATTAAGAAAGACCTGAGCTGTCTTCCTTGGCACTGCCTATGGAGGTGACACCCATCTCCTCCAT
CATGGCCATCCTGAGACCGCTCGCGAAGCCCAAGATCATCAAAAAGAGCACCAAGTTCACTGGGAACCAGTCAGACTGATATGTCAAAAT
TAAGGGTAACTGGTGGAAACACAGAGGTATTAACAACAGGGTTCATAGAAGGTTTGAGGGCCAGATCTATGCCCAACATTGGTTATGGGA
GAAACAAAAAGACAAAGCACATACTGCCCAGTGGCTTCTGGAAGTTCCTGGTCCACAACGTTAAGGAGCTGGAAGTACTGCTGGTGAGCA
ACAAATCTTACTGTGTTGAGATCACTCATGATGTTTCTTCCAAGAACTGCAAAGCCATCTTGGAAAGAGCAGCCCAGGTGGTCATCAGAG
TCACCAATGCCAATGCCAGCCTGCACAGTGCAGAAAGTGAATAGACAGTGAATGTGTTTGTTTTATTGGGGTTTAAATAAAACCAATAAA
ACTGTAAAAACAAAAACAACAAAAACCAGAGACCCTGGCTTTTGGACAGTTGTTCGTGTGGCTAATGCCCCCAACAGTTTTATTTTTTAA
AATTTTATTTATGTATTGTTTTTGAGATGAAGTCTTCCTCTGACTGGAGTGCAGTGATGCAAGCTCAGCTCTCTGCAACTTCCACCTCCC
AGGTTCAAGTGATTCTTCTGTCTCAGCCTCCCAAGTGGCTGGGATTACAGGTGCCCACTACCACACCTGACTAATTTTTGTATTTTTGTA
GAGATGGGGTTTCATCCTCTTGGCCAGGCTGGTTTCGAACTCCTGACCTCAAGGGATCCTCCCACCTCAGCTTCCCAAAGTGCTGGGATC
ACAGGCTTGTATTAGTTCATTTTCACACTGCTGATAAAGACATACCTAAGACTGGGAAGAAAAATAGGTTTATTGGACTCACAGTTCCAT
GTGGCTGGGGATGCCTCACAATTATGGTAGAAGGCAAAAGGCACTTCTTAGATGGCAGCGGCAAGCAGGAAATGAGGAAGACATGAAAGC
AGATATCCCTTATAAAACCATCAGTTCTCGTGATACTTACTCACTACCATGAGAAAGTATGGGGGAAACCGCTCCCATGATTCAGTTATC

>30904_30904_4_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000492622_RPS29_chr14_50052767_ENST00000396020_length(amino acids)=374AA_BP=326
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIED
NGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDER
SSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSN
IVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFI

--------------------------------------------------------------
>30904_30904_5_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000541916_RPS29_chr14_50052767_ENST00000245458_length(transcript)=1254nt_BP=1050nt
TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC
ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCT
GGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGAT
GTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGGTTATTGAAGACAATGGTGTTCGAAGAGTTGTCGT
GGTCCCTCAGGCACCAGAGTTTCACCCTGGTAGTCACACAGTTCTCCACCGTTCTCCACATCCTCCTCTACCTGGTTTCATTCCTGTCCC
AACTATGATGCCGCCTCCACCACGTCATATGTACTCACCCGTGACTGGAGCTGGAGACATGACAACACAGTATATGCCACAGTATCAGTC
TTCACAAGTCTATGGAGATGTAGATGCTCACTCTACACATGGAAGGTCCAACTTTAGAGATGAACGATCTAGTAAAACATATGAACGTTT
GCAGAAAAAATTGAAGGATCGCCAAGGAACACAGAAAGATAAAATGAGCAGTCCACCATCATCACCCCAGAAATGCCCTTCTCCCATTAA
TGAACATAATGGACTTATAAAAGGACAAATTGCTGGTGGTATAAACACAGGATCAGCAAAAATCAAGTCTGGGAAGGGGAAAGGTGGTAC
ACAAGTTGATACAGAAATTGAAGAAAAAGATGAAGAAACTAAAGCATTTGAAGCACTTCTTTCCAACATTGTCAAACCAGTGGCCTCCGA
CATCCAGGCAAGGACAGTAGTACTTACCTGGTCACCACCTTCCAGCCTCATTAATGGTGAAACAGATGAAAGTAGTGTACCAGAGCTCTA
TGGTTATGAAGTTCTGATCTCAAGTACTGGAAAAGATGGGAAATACAAAAGTGTATATGTTCGTGTCTGTTCAAACCGGCACGGTCTGAT
CCGGAAATATGGCCTCAATATGTGCCGCCAGTGTTTCCGTCAGTACGCGAAGGATATCGGTTTCATTAAGTTGGACTAAATGCTCTTCCT

>30904_30904_5_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000541916_RPS29_chr14_50052767_ENST00000245458_length(amino acids)=363AA_BP=326
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIED
NGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDER
SSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSN
IVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFI

--------------------------------------------------------------
>30904_30904_6_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000541916_RPS29_chr14_50052767_ENST00000396020_length(transcript)=2332nt_BP=1050nt
TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC
ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCT
GGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGAT
GTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGGTTATTGAAGACAATGGTGTTCGAAGAGTTGTCGT
GGTCCCTCAGGCACCAGAGTTTCACCCTGGTAGTCACACAGTTCTCCACCGTTCTCCACATCCTCCTCTACCTGGTTTCATTCCTGTCCC
AACTATGATGCCGCCTCCACCACGTCATATGTACTCACCCGTGACTGGAGCTGGAGACATGACAACACAGTATATGCCACAGTATCAGTC
TTCACAAGTCTATGGAGATGTAGATGCTCACTCTACACATGGAAGGTCCAACTTTAGAGATGAACGATCTAGTAAAACATATGAACGTTT
GCAGAAAAAATTGAAGGATCGCCAAGGAACACAGAAAGATAAAATGAGCAGTCCACCATCATCACCCCAGAAATGCCCTTCTCCCATTAA
TGAACATAATGGACTTATAAAAGGACAAATTGCTGGTGGTATAAACACAGGATCAGCAAAAATCAAGTCTGGGAAGGGGAAAGGTGGTAC
ACAAGTTGATACAGAAATTGAAGAAAAAGATGAAGAAACTAAAGCATTTGAAGCACTTCTTTCCAACATTGTCAAACCAGTGGCCTCCGA
CATCCAGGCAAGGACAGTAGTACTTACCTGGTCACCACCTTCCAGCCTCATTAATGGTGAAACAGATGAAAGTAGTGTACCAGAGCTCTA
TGGTTATGAAGTTCTGATCTCAAGTACTGGAAAAGATGGGAAATACAAAAGTGTATATGTTCGTGTCTGTTCAAACCGGCACGGTCTGAT
CCGGAAATATGGCCTCAATATGTGCCGCCAGTGTTTCCGTCAGTACGCGAAGGATATCGGTTTCATTAAGAAAGACCTGAGCTGTCTTCC
TTGGCACTGCCTATGGAGGTGACACCCATCTCCTCCATCATGGCCATCCTGAGACCGCTCGCGAAGCCCAAGATCATCAAAAAGAGCACC
AAGTTCACTGGGAACCAGTCAGACTGATATGTCAAAATTAAGGGTAACTGGTGGAAACACAGAGGTATTAACAACAGGGTTCATAGAAGG
TTTGAGGGCCAGATCTATGCCCAACATTGGTTATGGGAGAAACAAAAAGACAAAGCACATACTGCCCAGTGGCTTCTGGAAGTTCCTGGT
CCACAACGTTAAGGAGCTGGAAGTACTGCTGGTGAGCAACAAATCTTACTGTGTTGAGATCACTCATGATGTTTCTTCCAAGAACTGCAA
AGCCATCTTGGAAAGAGCAGCCCAGGTGGTCATCAGAGTCACCAATGCCAATGCCAGCCTGCACAGTGCAGAAAGTGAATAGACAGTGAA
TGTGTTTGTTTTATTGGGGTTTAAATAAAACCAATAAAACTGTAAAAACAAAAACAACAAAAACCAGAGACCCTGGCTTTTGGACAGTTG
TTCGTGTGGCTAATGCCCCCAACAGTTTTATTTTTTAAAATTTTATTTATGTATTGTTTTTGAGATGAAGTCTTCCTCTGACTGGAGTGC
AGTGATGCAAGCTCAGCTCTCTGCAACTTCCACCTCCCAGGTTCAAGTGATTCTTCTGTCTCAGCCTCCCAAGTGGCTGGGATTACAGGT
GCCCACTACCACACCTGACTAATTTTTGTATTTTTGTAGAGATGGGGTTTCATCCTCTTGGCCAGGCTGGTTTCGAACTCCTGACCTCAA
GGGATCCTCCCACCTCAGCTTCCCAAAGTGCTGGGATCACAGGCTTGTATTAGTTCATTTTCACACTGCTGATAAAGACATACCTAAGAC
TGGGAAGAAAAATAGGTTTATTGGACTCACAGTTCCATGTGGCTGGGGATGCCTCACAATTATGGTAGAAGGCAAAAGGCACTTCTTAGA
TGGCAGCGGCAAGCAGGAAATGAGGAAGACATGAAAGCAGATATCCCTTATAAAACCATCAGTTCTCGTGATACTTACTCACTACCATGA

>30904_30904_6_FNDC3A-RPS29_FNDC3A_chr13_49720071_ENST00000541916_RPS29_chr14_50052767_ENST00000396020_length(amino acids)=374AA_BP=326
MIMAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIED
NGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDER
SSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSN
IVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FNDC3A-RPS29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FNDC3A-RPS29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FNDC3A-RPS29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource