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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FNDC3B-CLDN11 (FusionGDB2 ID:30912)

Fusion Gene Summary for FNDC3B-CLDN11

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3B-CLDN11
Fusion gene ID: 30912
HgeneTgene
Gene symbol

FNDC3B

CLDN11

Gene ID

64778

5010

Gene namefibronectin type III domain containing 3Bclaudin 11
SynonymsFAD104|PRO4979|YVTM2421OSP|OTM
Cytomap

3q26.31

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104claudin-11oligodendrocyte transmembrane proteinoligodendrocyte-specific protein
Modification date2020031320200313
UniProtAcc

Q53EP0

O75508

Ensembl transtripts involved in fusion geneENST00000336824, ENST00000415807, 
ENST00000416957, ENST00000392699, 
ENST00000421757, ENST00000423424, 
ENST00000476794, 		ENST00000064724, 
ENST00000489485, ENST00000451576, 
ENST00000486975, 
Fusion gene scores* DoF score30 X 18 X 19=1026010 X 9 X 9=810
# samples 3910
** MAII scorelog2(39/10260*10)=-4.71741279674481
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/810*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNDC3B [Title/Abstract] AND CLDN11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFNDC3B(171969331)-CLDN11(170425833), # samples:1
Anticipated loss of major functional domain due to fusion event.FNDC3B-CLDN11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLDN11

GO:0120192

tight junction assembly

30734065


check buttonFusion gene breakpoints across FNDC3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLDN11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-A8HF-01AFNDC3Bchr3

171969331

+CLDN11chr3

170425833

+


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Fusion Gene ORF analysis for FNDC3B-CLDN11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336824ENST00000064724FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
5CDS-intronENST00000336824ENST00000489485FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
5CDS-intronENST00000415807ENST00000064724FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
5CDS-intronENST00000415807ENST00000489485FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
5CDS-intronENST00000416957ENST00000064724FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
5CDS-intronENST00000416957ENST00000489485FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
Frame-shiftENST00000336824ENST00000451576FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
Frame-shiftENST00000415807ENST00000451576FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
Frame-shiftENST00000416957ENST00000451576FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
In-frameENST00000336824ENST00000486975FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
In-frameENST00000415807ENST00000486975FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
In-frameENST00000416957ENST00000486975FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000392699ENST00000451576FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000392699ENST00000486975FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000421757ENST00000451576FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000421757ENST00000486975FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000423424ENST00000451576FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000423424ENST00000486975FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000476794ENST00000451576FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-3CDSENST00000476794ENST00000486975FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000392699ENST00000064724FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000392699ENST00000489485FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000421757ENST00000064724FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000421757ENST00000489485FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000423424ENST00000064724FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000423424ENST00000489485FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000476794ENST00000064724FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+
intron-intronENST00000476794ENST00000489485FNDC3Bchr3

171969331

+CLDN11chr3

170425833

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415807FNDC3Bchr3171969331+ENST00000486975CLDN11chr3170425833+15119621721068298
ENST00000336824FNDC3Bchr3171969331+ENST00000486975CLDN11chr3170425833+143888999995298
ENST00000416957FNDC3Bchr3171969331+ENST00000486975CLDN11chr3170425833+140285363959298

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415807ENST00000486975FNDC3Bchr3171969331+CLDN11chr3170425833+0.0039894960.99601054
ENST00000336824ENST00000486975FNDC3Bchr3171969331+CLDN11chr3170425833+0.0035649110.99643505
ENST00000416957ENST00000486975FNDC3Bchr3171969331+CLDN11chr3170425833+0.003637150.99636286

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Fusion Genomic Features for FNDC3B-CLDN11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FNDC3Bchr3171969331+CLDN11chr3170425832+1.43E-060.99999857
FNDC3Bchr3171969331+CLDN11chr3170425832+1.43E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FNDC3B-CLDN11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:171969331/chr3:170425833)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3B

Q53EP0

CLDN11

O75508

FUNCTION: May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626231_2432631205.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626231_2432631205.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626231_2432631205.0Compositional biasNote=Poly-Gly
TgeneCLDN11chr3:171969331chr3:170425833ENST0000006472403104_1220208.0Topological domainCytoplasmic
TgeneCLDN11chr3:171969331chr3:170425833ENST0000006472403144_1570208.0Topological domainExtracellular
TgeneCLDN11chr3:171969331chr3:170425833ENST0000006472403179_2070208.0Topological domainCytoplasmic
TgeneCLDN11chr3:171969331chr3:170425833ENST00000064724031_10208.0Topological domainCytoplasmic
TgeneCLDN11chr3:171969331chr3:170425833ENST000000647240323_820208.0Topological domainExtracellular
TgeneCLDN11chr3:171969331chr3:170425833ENST0000006472403123_1430208.0TransmembraneHelical
TgeneCLDN11chr3:171969331chr3:170425833ENST0000006472403158_1780208.0TransmembraneHelical
TgeneCLDN11chr3:171969331chr3:170425833ENST00000064724032_220208.0TransmembraneHelical
TgeneCLDN11chr3:171969331chr3:170425833ENST000000647240383_1030208.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14231_243072.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14231_243072.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+6261056_11532631205.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626278_3772631205.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626381_4732631205.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626477_5702631205.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626574_6692631205.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626673_7652631205.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626766_8592631205.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626871_9572631205.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+626958_10522631205.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+6261056_11532631205.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626278_3772631205.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626381_4732631205.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626477_5702631205.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626574_6692631205.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626673_7652631205.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626766_8592631205.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626871_9572631205.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+626958_10522631205.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+6261056_11532631205.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626278_3772631205.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626381_4732631205.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626477_5702631205.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626574_6692631205.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626673_7652631205.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626766_8592631205.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626871_9572631205.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+626958_10522631205.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+141056_1153072.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14278_377072.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14381_473072.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14477_570072.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14574_669072.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14673_765072.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14766_859072.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14871_957072.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+14958_1052072.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+141056_1153072.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14278_377072.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14381_473072.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14477_570072.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14574_669072.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14673_765072.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14766_859072.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14871_957072.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+14958_1052072.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000336824+6261182_12022631205.0TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000415807+6261182_12022631205.0TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000416957+6261182_12022631205.0TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000421757+141182_1202072.0TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr3:170425833ENST00000423424+141182_1202072.0TransmembraneHelical


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Fusion Gene Sequence for FNDC3B-CLDN11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30912_30912_1_FNDC3B-CLDN11_FNDC3B_chr3_171969331_ENST00000336824_CLDN11_chr3_170425833_ENST00000486975_length(transcript)=1438nt_BP=889nt
AAGCTCGGGCGGGGGAGCGGGGCGCGGCGGGAAGGAGCGGGCGACCCGGTGTGTGGGCCAGCGGAGCTCCGGAAGCCAGTTGAGGGAAGT
TCTCCATGAATGTACGTCACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCC
CACTTGGTGAATGGAGATGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACA
CTTCAGTGCATTCAAGGACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCA
CAGGTGATTGAAGATAGTACTGGAGTCCGCCGGGTGGTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATG
TCTCCAACCCATCATCTCCCTCCCTATCTGACTCACCATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGA
CCTGGAGATATGCCGCCTCAGTTTTTTCCCCAGCATCATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATG
TCAACCTACATCACCCGAGAAGACCAGTACAGCAAGCCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAAC
AGCCCTCCTTCTTCTATCTACAAAAGCAGCTGCACAACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGC
AGCGGTAGTGGTCCCGGAATTAAGAAAACAGAGCGACGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGTCAGCTT
CTTTGGGCAAAGACTGAGTCATCTCTGCATTCTCAGCACCTGGTGCAATTTAAGCAGAAATATCTTGAAGATTTTTCGTATCTTCAGGGA
GATTAGGAATGGGAATGGAATGGGAACGCCAATGCAGGAAGGATGAGAAGTCTGCAGATGCCTCCAAGGAGTCCGAAACCAAGTCCGAAG
TCAACGACAAGCAATGATGGCGATGGCGATCCTAGTTAATAAAAAGGGGGGAGATGTGGGCTGCAAGCCACCCAGGTGCCGAGGCAAGAG
ACCGAGGACATGAGCTGTTCCAGTATAATAAAATATAAAACAAGAATAGTTATACCAGATATAGATCTTAGATATGATTATATATGAATA
TAATTAATCATTAGTTTGTGGCAATTACTCTTTATTCCAATATTATAATAATCCTCGCTCTATAATCATAACCTAGGAAAAACCAGGCCA

>30912_30912_1_FNDC3B-CLDN11_FNDC3B_chr3_171969331_ENST00000336824_CLDN11_chr3_170425833_ENST00000486975_length(amino acids)=298AA_BP=263
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVI
EDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGSGPGIKKTERRARSSPKSNDSDLQGCQLLWA

--------------------------------------------------------------
>30912_30912_2_FNDC3B-CLDN11_FNDC3B_chr3_171969331_ENST00000415807_CLDN11_chr3_170425833_ENST00000486975_length(transcript)=1511nt_BP=962nt
GCGGCGGCGGCGGCTGGAGGAGGAGAGCGGCGGCGGCGGGAGCAGCGAAGGGGGCGGCAGGGATCCTCCAGGCTGCCGGCTGGGAAGGCG
TGGGCGACCCGGTGTGTGGCGCGCCCAGAGCCCCGCGTTTCAGCCCTAGGGAAGGAAGCCAGTTGAGGGAAGTTCTCCATGAATGTACGT
CACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTGAATGGAGA
TGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGCATTCAAGG
ACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGTGATTGAAGATAG
TACTGGAGTCCGCCGGGTGGTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATGTCTCCAACCCATCATCT
CCCTCCCTATCTGACTCACCATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGACCTGGAGATATGCCGCC
TCAGTTTTTTCCCCAGCATCATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATGTCAACCTACATCACCCG
AGAAGACCAGTACAGCAAGCCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAACAGCCCTCCTTCTTCTAT
CTACAAAAGCAGCTGCACAACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGCAGCGGTAGTGGTCCCGG
AATTAAGAAAACAGAGCGACGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGTCAGCTTCTTTGGGCAAAGACTGA
GTCATCTCTGCATTCTCAGCACCTGGTGCAATTTAAGCAGAAATATCTTGAAGATTTTTCGTATCTTCAGGGAGATTAGGAATGGGAATG
GAATGGGAACGCCAATGCAGGAAGGATGAGAAGTCTGCAGATGCCTCCAAGGAGTCCGAAACCAAGTCCGAAGTCAACGACAAGCAATGA
TGGCGATGGCGATCCTAGTTAATAAAAAGGGGGGAGATGTGGGCTGCAAGCCACCCAGGTGCCGAGGCAAGAGACCGAGGACATGAGCTG
TTCCAGTATAATAAAATATAAAACAAGAATAGTTATACCAGATATAGATCTTAGATATGATTATATATGAATATAATTAATCATTAGTTT
GTGGCAATTACTCTTTATTCCAATATTATAATAATCCTCGCTCTATAATCATAACCTAGGAAAAACCAGGCCATACAGAGATAGGAGCTG

>30912_30912_2_FNDC3B-CLDN11_FNDC3B_chr3_171969331_ENST00000415807_CLDN11_chr3_170425833_ENST00000486975_length(amino acids)=298AA_BP=263
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVI
EDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGSGPGIKKTERRARSSPKSNDSDLQGCQLLWA

--------------------------------------------------------------
>30912_30912_3_FNDC3B-CLDN11_FNDC3B_chr3_171969331_ENST00000416957_CLDN11_chr3_170425833_ENST00000486975_length(transcript)=1402nt_BP=853nt
AGTGTCTACCACCAAACTCCTAAGGCTGGATGGTGGAAGCCAGTTGAGGGAAGTTCTCCATGAATGTACGTCACAATGATGATGACCGAC
CAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTGAATGGAGATGCAGCTCAGCAGGTTATT
CTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGCATTCAAGGACCTGCTGAAGTTCCCATG
ATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGTGATTGAAGATAGTACTGGAGTCCGCCGGGTG
GTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATGTCTCCAACCCATCATCTCCCTCCCTATCTGACTCAC
CATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGACCTGGAGATATGCCGCCTCAGTTTTTTCCCCAGCAT
CATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATGTCAACCTACATCACCCGAGAAGACCAGTACAGCAAG
CCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAACAGCCCTCCTTCTTCTATCTACAAAAGCAGCTGCACA
ACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGCAGCGGTAGTGGTCCCGGAATTAAGAAAACAGAGCGA
CGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGTCAGCTTCTTTGGGCAAAGACTGAGTCATCTCTGCATTCTCAG
CACCTGGTGCAATTTAAGCAGAAATATCTTGAAGATTTTTCGTATCTTCAGGGAGATTAGGAATGGGAATGGAATGGGAACGCCAATGCA
GGAAGGATGAGAAGTCTGCAGATGCCTCCAAGGAGTCCGAAACCAAGTCCGAAGTCAACGACAAGCAATGATGGCGATGGCGATCCTAGT
TAATAAAAAGGGGGGAGATGTGGGCTGCAAGCCACCCAGGTGCCGAGGCAAGAGACCGAGGACATGAGCTGTTCCAGTATAATAAAATAT
AAAACAAGAATAGTTATACCAGATATAGATCTTAGATATGATTATATATGAATATAATTAATCATTAGTTTGTGGCAATTACTCTTTATT
CCAATATTATAATAATCCTCGCTCTATAATCATAACCTAGGAAAAACCAGGCCATACAGAGATAGGAGCTGAGGGGACATAGTGAGGAGT

>30912_30912_3_FNDC3B-CLDN11_FNDC3B_chr3_171969331_ENST00000416957_CLDN11_chr3_170425833_ENST00000486975_length(amino acids)=298AA_BP=263
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVI
EDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGSGPGIKKTERRARSSPKSNDSDLQGCQLLWA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FNDC3B-CLDN11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FNDC3B-CLDN11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FNDC3B-CLDN11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource