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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FNDC3B-TNIK (FusionGDB2 ID:30939)

Fusion Gene Summary for FNDC3B-TNIK

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3B-TNIK
Fusion gene ID: 30939
HgeneTgene
Gene symbol

FNDC3B

TNIK

Gene ID

64778

23043

Gene namefibronectin type III domain containing 3BTRAF2 and NCK interacting kinase
SynonymsFAD104|PRO4979|YVTM2421MRT54
Cytomap

3q26.31

3q26.2-q26.31

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104TRAF2 and NCK-interacting protein kinase
Modification date2020031320200313
UniProtAcc

Q53EP0

.
Ensembl transtripts involved in fusion geneENST00000336824, ENST00000392699, 
ENST00000415807, ENST00000416957, 
ENST00000421757, ENST00000423424, 
ENST00000476794, 		ENST00000284483, 
ENST00000341852, ENST00000357327, 
ENST00000369326, ENST00000436636, 
ENST00000460047, ENST00000464785, 
ENST00000465393, ENST00000470834, 
ENST00000475336, ENST00000488470, 
ENST00000538048, 
Fusion gene scores* DoF score30 X 18 X 19=1026013 X 13 X 4=676
# samples 3916
** MAII scorelog2(39/10260*10)=-4.71741279674481
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/676*10)=-2.07895134139482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNDC3B [Title/Abstract] AND TNIK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFNDC3B(171851336)-TNIK(171065007), # samples:5
TNIK(171087408)-FNDC3B(172025152), # samples:1
Anticipated loss of major functional domain due to fusion event.FNDC3B-TNIK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FNDC3B-TNIK seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FNDC3B-TNIK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FNDC3B-TNIK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
TNIK-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNIK-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TNIK-FNDC3B seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TNIK-FNDC3B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNIK

GO:0006468

protein phosphorylation

10521462|15342639|22797597

TgeneTNIK

GO:0007256

activation of JNKK activity

15342639

TgeneTNIK

GO:0031532

actin cytoskeleton reorganization

15342639

TgeneTNIK

GO:0035556

intracellular signal transduction

10521462

TgeneTNIK

GO:0046777

protein autophosphorylation

10521462|15342639

TgeneTNIK

GO:0048814

regulation of dendrite morphogenesis

20159449


check buttonFusion gene breakpoints across FNDC3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNIK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A88S-01AFNDC3Bchr3

171851336

-TNIKchr3

171065007

-
ChimerDB4ESCATCGA-L5-A88S-01AFNDC3Bchr3

171851336

+TNIKchr3

171065007

-
ChimerDB4ESCATCGA-L5-A88SFNDC3Bchr3

171851336

+TNIKchr3

170946010

-
ChimerDB4ESCATCGA-L5-A88SFNDC3Bchr3

171851336

+TNIKchr3

171065007

-


Top

Fusion Gene ORF analysis for FNDC3B-TNIK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336824ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000336824ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000336824ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000336824ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000392699ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000392699ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000392699ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000415807ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000415807ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000415807ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000416957ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000416957ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000416957ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000421757ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000421757ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000421757ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000423424ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
5CDS-intronENST00000423424ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
5CDS-intronENST00000423424ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
Frame-shiftENST00000336824ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000336824ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000392699ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000415807ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000416957ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000421757ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
Frame-shiftENST00000423424ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-3CDSENST00000476794ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-intronENST00000476794ENST00000284483FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000341852FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000357327FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000369326FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000436636FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000460047FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000464785FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-intronENST00000476794ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000465393FNDC3Bchr3

171851336

+TNIKchr3

170946010

-
intron-intronENST00000476794ENST00000470834FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000475336FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000488470FNDC3Bchr3

171851336

+TNIKchr3

171065007

-
intron-intronENST00000476794ENST00000538048FNDC3Bchr3

171851336

+TNIKchr3

171065007

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FNDC3B-TNIK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FNDC3B-TNIK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:171851336/:171065007)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3B

Q53EP0

.
FUNCTION: May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FNDC3B-TNIK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FNDC3B-TNIK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FNDC3B-TNIK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FNDC3B-TNIK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource