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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AHI1-NIN (FusionGDB2 ID:3096)

Fusion Gene Summary for AHI1-NIN

check button Fusion gene summary
Fusion gene informationFusion gene name: AHI1-NIN
Fusion gene ID: 3096
HgeneTgene
Gene symbol

AHI1

NIN

Gene ID

54806

51199

Gene nameAbelson helper integration site 1ninein
SynonymsAHI-1|JBTS3|ORF1|dJ71N10.1SCKL7
Cytomap

6q23.3

14q22.1

Type of geneprotein-codingprotein-coding
Descriptionjouberinabelson helper integration site 1 protein homologcontatins SH3 and WD40 domainsnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal protein
Modification date2020031320200328
UniProtAcc.

Q9Y2I6

Ensembl transtripts involved in fusion geneENST00000327035, ENST00000367798, 
ENST00000457866, ENST00000488690, 
ENST00000531527, ENST00000367800, 
ENST00000417892, ENST00000528103, 
ENST00000534469, 		ENST00000245441, 
ENST00000324330, ENST00000382041, 
ENST00000382043, ENST00000389868, 
ENST00000453196, ENST00000530997, 
ENST00000486200, 
Fusion gene scores* DoF score10 X 11 X 6=6607 X 9 X 4=252
# samples 1010
** MAII scorelog2(10/660*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHI1 [Title/Abstract] AND NIN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAHI1(135818325)-NIN(51211083), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AHI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NIN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8297AHI1chr6

135818325

-NINchr14

51211083

-


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Fusion Gene ORF analysis for AHI1-NIN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000327035ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000327035ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000327035ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000327035ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000327035ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000327035ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000327035ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000367798ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000367798ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000367798ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000367798ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000367798ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000367798ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000367798ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000457866ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000457866ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000457866ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000457866ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000457866ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000457866ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000457866ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000488690ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000488690ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000488690ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000488690ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000488690ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000488690ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000488690ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000531527ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000531527ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000531527ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000531527ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000531527ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000531527ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-3CDSENST00000531527ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-intronENST00000327035ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-intronENST00000367798ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-intronENST00000457866ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-intronENST00000488690ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
5UTR-intronENST00000531527ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000367800ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000367800ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000367800ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000367800ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000367800ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000367800ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000367800ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000417892ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000417892ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000417892ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000417892ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000417892ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000417892ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000417892ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000528103ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000528103ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000528103ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000528103ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000528103ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000528103ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000528103ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000534469ENST00000245441AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000534469ENST00000324330AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000534469ENST00000382041AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000534469ENST00000382043AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000534469ENST00000389868AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000534469ENST00000453196AHI1chr6

135818325

-NINchr14

51211083

-
intron-3CDSENST00000534469ENST00000530997AHI1chr6

135818325

-NINchr14

51211083

-
intron-intronENST00000367800ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
intron-intronENST00000417892ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
intron-intronENST00000528103ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-
intron-intronENST00000534469ENST00000486200AHI1chr6

135818325

-NINchr14

51211083

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AHI1-NIN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AHI1-NIN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:135818325/:51211083)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NIN

Q9Y2I6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AHI1-NIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AHI1-NIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AHI1-NIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AHI1-NIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource