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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:AHI1-RPL22 (FusionGDB2 ID:3097)

Fusion Gene Summary for AHI1-RPL22

Fusion gene summary

Fusion gene information	Fusion gene name: AHI1-RPL22
	Fusion gene ID: 3097
		Hgene	Tgene
	Gene symbol	AHI1	RPL22
	Gene ID	54806	6146
	Gene name	Abelson helper integration site 1	ribosomal protein L22
	Synonyms	AHI-1\|JBTS3\|ORF1\|dJ71N10.1	EAP\|HBP15\|HBP15/L22\|L22
	Cytomap	6q23.3	1p36.31
	Type of gene	protein-coding	protein-coding
	Description	jouberinabelson helper integration site 1 protein homologcontatins SH3 and WD40 domains	60S ribosomal protein L22EBER-associated proteinEpstein-Barr virus small RNA-associated proteinEpstein-Barr-encoded RNA-associated proteinheparin-binding protein 15heparin-binding protein HBp15large ribosomal subunit protein eL22
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000327035, ENST00000367798, ENST00000367800, ENST00000457866, ENST00000488690, ENST00000417892, ENST00000528103, ENST00000531527, ENST00000534469,	ENST00000497965, ENST00000234875, ENST00000484532,
Fusion gene scores	* DoF score	10 X 11 X 6=660	11 X 8 X 6=528
	# samples	10	12
	** MAII score	log2(10/660*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AHI1 [Title/Abstract] AND RPL22 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AHI1(135811761)-RPL22(6257816), # samples:1
Anticipated loss of major functional domain due to fusion event.	AHI1-RPL22 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. AHI1-RPL22 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. AHI1-RPL22 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. AHI1-RPL22 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across AHI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPL22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4HB-01A	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-

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Fusion Gene ORF analysis for AHI1-RPL22

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000327035	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
5CDS-5UTR	ENST00000367798	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
5CDS-5UTR	ENST00000367800	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
5CDS-5UTR	ENST00000457866	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
5CDS-5UTR	ENST00000488690	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
Frame-shift	ENST00000367798	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
Frame-shift	ENST00000367798	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
Frame-shift	ENST00000367800	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
Frame-shift	ENST00000367800	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
Frame-shift	ENST00000488690	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
Frame-shift	ENST00000488690	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
In-frame	ENST00000327035	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
In-frame	ENST00000327035	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
In-frame	ENST00000457866	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
In-frame	ENST00000457866	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000417892	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000417892	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000528103	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000528103	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000531527	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000531527	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000534469	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-3CDS	ENST00000534469	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-5UTR	ENST00000417892	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-5UTR	ENST00000528103	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-5UTR	ENST00000531527	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-
intron-5UTR	ENST00000534469	ENST00000497965	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000457866	AHI1	chr6	135811761	-	ENST00000484532	RPL22	chr1	6257816	-	883	434	803	411	130
ENST00000457866	AHI1	chr6	135811761	-	ENST00000234875	RPL22	chr1	6257816	-	2461	434	299	808	169
ENST00000327035	AHI1	chr6	135811761	-	ENST00000484532	RPL22	chr1	6257816	-	863	414	783	391	130
ENST00000327035	AHI1	chr6	135811761	-	ENST00000234875	RPL22	chr1	6257816	-	2441	414	279	788	169

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000457866	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-	0.12105141	0.87894857
ENST00000457866	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-	0.002537533	0.9974624
ENST00000327035	ENST00000484532	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-	0.14712591	0.85287404
ENST00000327035	ENST00000234875	AHI1	chr6	135811761	-	RPL22	chr1	6257816	-	0.002223588	0.99777645

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Fusion Genomic Features for AHI1-RPL22

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AHI1-RPL22

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:135811761/chr1:6257816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

13_45

1054.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

13_45

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

13_45

1197.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RPL22

chr6:135811761

chr1:6257816

ENST00000234875

120_128

129.0

Compositional bias

Note=Asp/Glu-rich (highly acidic)

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

234_239

1054.0

Compositional bias

Note=Poly-Lys

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

234_239

1197.0

Compositional bias

Note=Poly-Lys

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

234_239

1197.0

Compositional bias

Note=Poly-Lys

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

1051_1111

1054.0

Domain

SH3

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

1051_1111

1197.0

Domain

SH3

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

1051_1111

1197.0

Domain

SH3

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

607_649

1054.0

Repeat

Note=WD 1

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

652_691

1054.0

Repeat

Note=WD 2

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

695_735

1054.0

Repeat

Note=WD 3

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

742_781

1054.0

Repeat

Note=WD 4

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

797_837

1054.0

Repeat

Note=WD 5

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

841_880

1054.0

Repeat

Note=WD 6

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000327035

885_926

1054.0

Repeat

Note=WD 7

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

607_649

1197.0

Repeat

Note=WD 1

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

652_691

1197.0

Repeat

Note=WD 2

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

695_735

1197.0

Repeat

Note=WD 3

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

742_781

1197.0

Repeat

Note=WD 4

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

797_837

1197.0

Repeat

Note=WD 5

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

841_880

1197.0

Repeat

Note=WD 6

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000367800

885_926

1197.0

Repeat

Note=WD 7

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

607_649

1197.0

Repeat

Note=WD 1

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

652_691

1197.0

Repeat

Note=WD 2

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

695_735

1197.0

Repeat

Note=WD 3

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

742_781

1197.0

Repeat

Note=WD 4

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

797_837

1197.0

Repeat

Note=WD 5

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

841_880

1197.0

Repeat

Note=WD 6

Hgene

AHI1

chr6:135811761

chr1:6257816

ENST00000457866

885_926

1197.0

Repeat

Note=WD 7

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Fusion Gene Sequence for AHI1-RPL22

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>3097_3097_1_AHI1-RPL22_AHI1_chr6_135811761_ENST00000327035_RPL22_chr1_6257816_ENST00000234875_length(transcript)=2441nt_BP=414nt
GCGGCACAGAGCCGCGGCTTGCTTTCAGGACACGGGTCGCTGGCGGGTTAGGTGGCTGCGTGGCCGCCTCACTTCGCGCACGCGCCGCTA
GGCTGGGGGAGTTGATTTGCACTGCTCCGGGTGTCGGCTCCGGCGGGACGGGCGGTTCTGCGTACCCCTCTCCAGTGTCAACCTGGGGCT
GAATCTTCAACCTGTCAAAGCCTTCTTAATTATGTCTGAGAAAAGGATCCTGATTGAGTCAATGCTTTGCATTCTCAGTCCTCTGCATAA
AGCTGAGAGATGCCTACAGCTGAGAGTGAAGCAAAAGTAAAAACCAAAGTTCGCTTTGAAGAATTGCTTAAGACCCACAGTGATCTAATG
CGTGAAAAGAAAAAACTGAAGAAAAAACTTGTCAGGTCTGAAGAAAACATCTCAAAAAAGCTTGTGGTGAAGGGGGGCAAAAAAAAGAAG
CAAGTTCTGAAGTTCACTCTTGATTGCACCCACCCTGTAGAAGATGGAATCATGGATGCTGCCAATTTTGAGCAGTTTTTGCAAGAAAGG
ATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAGGGGTGGTGACCATCGAAAGGAGCAAGAGCAAGATCACCGTGACATCCGAGGTG
CCTTTCTCCAAAAGGTATTTGAAATATCTCACCAAAAAATATTTGAAGAAGAATAATCTACGTGACTGGTTGCGCGTAGTTGCTAACAGC
AAAGAGAGTTACGAATTACGTTACTTCCAGATTAACCAGGACGAAGAAGAGGAGGAAGACGAGGATTAAATTTCATTTATCTGGAAAATT
TTGTATGAGTTCTTGAATAAAACTTGGGAACCAAAATGGTGGTTTATCCTTGTATCTCTGCAGTGTGGATTGAACAGAAAATTGGAAATC
ATAGTCAAAGGGCTTCCCTTGGTTCGCCACTCATTTATTTGTAACTTGACTTCTTTTTTTTTCTGCTTAAAAATTTCAATTCTCGTGGTA
ATACCAGAGTAGAAGGAGAGGGTGACTTTACCGAACTGACAGCCATTGGGGAGGCAGATGCGGGTGTGGAGGTGTGGGCTGAAGGTAGTG
ACTGTTTGATTTTAAAAAGTGTGACTGTCAGTTGTATCTGTTGCTTTTCTCAATGATTCAGGGATACAAATGGGCTTCTCTCATTCATTA
AAAGAAAACGCGACATCTTTCTAAGATTCTCTGTGGGAAAATGACTGTCAATAAAATGCGGGTTTCTGGGCCATTCGTCTTACTTTCATT
TTTTGATTACAAATTTCTCTTGACGCACACAATTATGTCTGCTAATCCTCTTCTTCCTAGAGAGAGAAACTGTGCTCCTTCAGTGTTGCT
GCCATAAAGGGGTTTGGGGAATCGATTGTAAAAGTCCCAGGTTCTAAATTAACTAAATGTGTACAGAAATGAACGTGTAAGTAATGTTTC
TACAGGTCTTTGCAACAAACTGTCACTTTCGTCTCCAGCAGAGGGAGCTGTAGGAATAGTGCTTCCAGATGTGGTCTCCCGTGTGGGGCC
CAGCAATGGGGGCCCCTGATGCCAAGAGCTCTGGAGGTTCTTGAAAGAGGGGACACGAAGGAGGAGTGACTGGGAAGCCTCCCATGCCAA
GGAGGTGGGAGGTGCCCTGGAAATAGCTGCCTCATGCCACTTAGGCCATGACTGGATTTAATGTCAGTGGTGTGCCACAGTGCAGAGGCT
AGACAACTGAAAGGGGCTACCAAGGCTGGGAAAAAAATGCAATTGTTGCTGTGAGTGACTTTGAAAGACTCTGGTGCCTTGTGGTGCCCT
TCTGAAATTCAAACAGTAATGCAAAAGTGTCTGCATTAGAATTTACGGTGTCTAAAATTCATGTTTTTAAAAGAGCTTGCCTACAGATGG
TTTCCACACTTGAAATTGTGCCCTGCGAGTTGCATAGCTGGAAGTTCAATGCTCAGTCCTACCTTGGCTCCCATTAAACATTTGGTGCTC
TGTGGATTGAGTTGAACGTGTTGAGGCTTTGCAATTTCACTTGTGTTAAAGGCTCTGGCATTTTTCCATTTCTATGCAAATTTCTTTGAA
GCAGAATTGCTTGCATATTTCTTCTCTGCCGTCACAGAAAGCAGAGTTTCTTTCAAACTTCACTGAGGCATCAGTTGCTCTTTGGCAATG
TCCCTTAACCATGATTATTAACTAAGTTTGTGGCTTGAGTTTACAAATTCTACTTGTTGCATTGATGTTCCCATGTAGTAAGTCATTTTT
AGTTTGGTTGTGAAAAAACCCTGGGCTGAAGTTGGCATTTCAGTTAAAAGAAAAAAAGAAACTAGTCCCAGATTTGAAAACTTGTAATAA
AATTGAAACTCACTGGTTTTCTATGTCTTTTTGAACTCTTGTAATCGAGTTTTGATCATATTTTCTATTAAAGTGGCTAACACCTGGCTA

>3097_3097_1_AHI1-RPL22_AHI1_chr6_135811761_ENST00000327035_RPL22_chr1_6257816_ENST00000234875_length(amino acids)=169AA_BP=45
MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKV

--------------------------------------------------------------
>3097_3097_2_AHI1-RPL22_AHI1_chr6_135811761_ENST00000327035_RPL22_chr1_6257816_ENST00000484532_length(transcript)=863nt_BP=414nt
GCGGCACAGAGCCGCGGCTTGCTTTCAGGACACGGGTCGCTGGCGGGTTAGGTGGCTGCGTGGCCGCCTCACTTCGCGCACGCGCCGCTA
GGCTGGGGGAGTTGATTTGCACTGCTCCGGGTGTCGGCTCCGGCGGGACGGGCGGTTCTGCGTACCCCTCTCCAGTGTCAACCTGGGGCT
GAATCTTCAACCTGTCAAAGCCTTCTTAATTATGTCTGAGAAAAGGATCCTGATTGAGTCAATGCTTTGCATTCTCAGTCCTCTGCATAA
AGCTGAGAGATGCCTACAGCTGAGAGTGAAGCAAAAGTAAAAACCAAAGTTCGCTTTGAAGAATTGCTTAAGACCCACAGTGATCTAATG
CGTGAAAAGAAAAAACTGAAGAAAAAACTTGTCAGGTCTGAAGAAAACATCTCAGAAAAAGCTTGTGGTGAAGGGGGGCAAAAAAAAGAA
GCAAGTTCTGAAGTTCACTCTTGATTGCACCCACCCTGTAGAAGATGGAATCATGGATGCTGCCAATTTTGAGCAGTTTTTGCAAGAAAG
GATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAGGGGTGGTGACCATCGAAAGGAGCAAGAGCAAGATCACCGTGACATCCGAGGT
GCCTTTCTCCAAAAGGCGGCCAGCACTGGGCTGACCCGGCTTCTCTATCTACAGCGTAGTTAAAGCGGATCTGGGAGATGGAGGGGTTCC
CAACACCCCAGTCTTTGGTTCCAGAAGGCTGGACCGACCTCTCCTTGCCCAGGGATGAATGCAGAGGGTCTTTTGTTTGGGGTTTGCTGG

>3097_3097_2_AHI1-RPL22_AHI1_chr6_135811761_ENST00000327035_RPL22_chr1_6257816_ENST00000484532_length(amino acids)=130AA_BP=1
MHSSLGKERSVQPSGTKDWGVGNPSISQIRFNYAVDREAGSAQCWPPFGERHLGCHGDLALAPFDGHHPSTKVPSFSVHFDPFLQKLLKI

--------------------------------------------------------------
>3097_3097_3_AHI1-RPL22_AHI1_chr6_135811761_ENST00000457866_RPL22_chr1_6257816_ENST00000234875_length(transcript)=2461nt_BP=434nt
GGCGGCGCGCTGTCCGCACTGCGGCACAGAGCCGCGGCTTGCTTTCAGGACACGGGTCGCTGGCGGGTTAGGTGGCTGCGTGGCCGCCTC
ACTTCGCGCACGCGCCGCTAGGCTGGGGGAGTTGATTTGCACTGCTCCGGGTGTCGGCTCCGGCGGGACGGGCGGTTCTGCGTACCCCTC
TCCAGTGTCAACCTGGGGCTGAATCTTCAACCTGTCAAAGCCTTCTTAATTATGTCTGAGAAAAGGATCCTGATTGAGTCAATGCTTTGC
ATTCTCAGTCCTCTGCATAAAGCTGAGAGATGCCTACAGCTGAGAGTGAAGCAAAAGTAAAAACCAAAGTTCGCTTTGAAGAATTGCTTA
AGACCCACAGTGATCTAATGCGTGAAAAGAAAAAACTGAAGAAAAAACTTGTCAGGTCTGAAGAAAACATCTCAAAAAAGCTTGTGGTGA
AGGGGGGCAAAAAAAAGAAGCAAGTTCTGAAGTTCACTCTTGATTGCACCCACCCTGTAGAAGATGGAATCATGGATGCTGCCAATTTTG
AGCAGTTTTTGCAAGAAAGGATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAGGGGTGGTGACCATCGAAAGGAGCAAGAGCAAGA
TCACCGTGACATCCGAGGTGCCTTTCTCCAAAAGGTATTTGAAATATCTCACCAAAAAATATTTGAAGAAGAATAATCTACGTGACTGGT
TGCGCGTAGTTGCTAACAGCAAAGAGAGTTACGAATTACGTTACTTCCAGATTAACCAGGACGAAGAAGAGGAGGAAGACGAGGATTAAA
TTTCATTTATCTGGAAAATTTTGTATGAGTTCTTGAATAAAACTTGGGAACCAAAATGGTGGTTTATCCTTGTATCTCTGCAGTGTGGAT
TGAACAGAAAATTGGAAATCATAGTCAAAGGGCTTCCCTTGGTTCGCCACTCATTTATTTGTAACTTGACTTCTTTTTTTTTCTGCTTAA
AAATTTCAATTCTCGTGGTAATACCAGAGTAGAAGGAGAGGGTGACTTTACCGAACTGACAGCCATTGGGGAGGCAGATGCGGGTGTGGA
GGTGTGGGCTGAAGGTAGTGACTGTTTGATTTTAAAAAGTGTGACTGTCAGTTGTATCTGTTGCTTTTCTCAATGATTCAGGGATACAAA
TGGGCTTCTCTCATTCATTAAAAGAAAACGCGACATCTTTCTAAGATTCTCTGTGGGAAAATGACTGTCAATAAAATGCGGGTTTCTGGG
CCATTCGTCTTACTTTCATTTTTTGATTACAAATTTCTCTTGACGCACACAATTATGTCTGCTAATCCTCTTCTTCCTAGAGAGAGAAAC
TGTGCTCCTTCAGTGTTGCTGCCATAAAGGGGTTTGGGGAATCGATTGTAAAAGTCCCAGGTTCTAAATTAACTAAATGTGTACAGAAAT
GAACGTGTAAGTAATGTTTCTACAGGTCTTTGCAACAAACTGTCACTTTCGTCTCCAGCAGAGGGAGCTGTAGGAATAGTGCTTCCAGAT
GTGGTCTCCCGTGTGGGGCCCAGCAATGGGGGCCCCTGATGCCAAGAGCTCTGGAGGTTCTTGAAAGAGGGGACACGAAGGAGGAGTGAC
TGGGAAGCCTCCCATGCCAAGGAGGTGGGAGGTGCCCTGGAAATAGCTGCCTCATGCCACTTAGGCCATGACTGGATTTAATGTCAGTGG
TGTGCCACAGTGCAGAGGCTAGACAACTGAAAGGGGCTACCAAGGCTGGGAAAAAAATGCAATTGTTGCTGTGAGTGACTTTGAAAGACT
CTGGTGCCTTGTGGTGCCCTTCTGAAATTCAAACAGTAATGCAAAAGTGTCTGCATTAGAATTTACGGTGTCTAAAATTCATGTTTTTAA
AAGAGCTTGCCTACAGATGGTTTCCACACTTGAAATTGTGCCCTGCGAGTTGCATAGCTGGAAGTTCAATGCTCAGTCCTACCTTGGCTC
CCATTAAACATTTGGTGCTCTGTGGATTGAGTTGAACGTGTTGAGGCTTTGCAATTTCACTTGTGTTAAAGGCTCTGGCATTTTTCCATT
TCTATGCAAATTTCTTTGAAGCAGAATTGCTTGCATATTTCTTCTCTGCCGTCACAGAAAGCAGAGTTTCTTTCAAACTTCACTGAGGCA
TCAGTTGCTCTTTGGCAATGTCCCTTAACCATGATTATTAACTAAGTTTGTGGCTTGAGTTTACAAATTCTACTTGTTGCATTGATGTTC
CCATGTAGTAAGTCATTTTTAGTTTGGTTGTGAAAAAACCCTGGGCTGAAGTTGGCATTTCAGTTAAAAGAAAAAAAGAAACTAGTCCCA
GATTTGAAAACTTGTAATAAAATTGAAACTCACTGGTTTTCTATGTCTTTTTGAACTCTTGTAATCGAGTTTTGATCATATTTTCTATTA

>3097_3097_3_AHI1-RPL22_AHI1_chr6_135811761_ENST00000457866_RPL22_chr1_6257816_ENST00000234875_length(amino acids)=169AA_BP=45
MPTAESEAKVKTKVRFEELLKTHSDLMREKKKLKKKLVRSEENISKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKV

--------------------------------------------------------------
>3097_3097_4_AHI1-RPL22_AHI1_chr6_135811761_ENST00000457866_RPL22_chr1_6257816_ENST00000484532_length(transcript)=883nt_BP=434nt
GGCGGCGCGCTGTCCGCACTGCGGCACAGAGCCGCGGCTTGCTTTCAGGACACGGGTCGCTGGCGGGTTAGGTGGCTGCGTGGCCGCCTC
ACTTCGCGCACGCGCCGCTAGGCTGGGGGAGTTGATTTGCACTGCTCCGGGTGTCGGCTCCGGCGGGACGGGCGGTTCTGCGTACCCCTC
TCCAGTGTCAACCTGGGGCTGAATCTTCAACCTGTCAAAGCCTTCTTAATTATGTCTGAGAAAAGGATCCTGATTGAGTCAATGCTTTGC
ATTCTCAGTCCTCTGCATAAAGCTGAGAGATGCCTACAGCTGAGAGTGAAGCAAAAGTAAAAACCAAAGTTCGCTTTGAAGAATTGCTTA
AGACCCACAGTGATCTAATGCGTGAAAAGAAAAAACTGAAGAAAAAACTTGTCAGGTCTGAAGAAAACATCTCAGAAAAAGCTTGTGGTG
AAGGGGGGCAAAAAAAAGAAGCAAGTTCTGAAGTTCACTCTTGATTGCACCCACCCTGTAGAAGATGGAATCATGGATGCTGCCAATTTT
GAGCAGTTTTTGCAAGAAAGGATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAGGGGTGGTGACCATCGAAAGGAGCAAGAGCAAG
ATCACCGTGACATCCGAGGTGCCTTTCTCCAAAAGGCGGCCAGCACTGGGCTGACCCGGCTTCTCTATCTACAGCGTAGTTAAAGCGGAT
CTGGGAGATGGAGGGGTTCCCAACACCCCAGTCTTTGGTTCCAGAAGGCTGGACCGACCTCTCCTTGCCCAGGGATGAATGCAGAGGGTC

>3097_3097_4_AHI1-RPL22_AHI1_chr6_135811761_ENST00000457866_RPL22_chr1_6257816_ENST00000484532_length(amino acids)=130AA_BP=1
MHSSLGKERSVQPSGTKDWGVGNPSISQIRFNYAVDREAGSAQCWPPFGERHLGCHGDLALAPFDGHHPSTKVPSFSVHFDPFLQKLLKI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AHI1-RPL22

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	AHI1	chr6:135811761	chr1:6257816	ENST00000327035	-	4	23	141_434	45.0	1054.0	HAP1
Hgene	AHI1	chr6:135811761	chr1:6257816	ENST00000367800	-	3	27	141_434	45.0	1197.0	HAP1
Hgene	AHI1	chr6:135811761	chr1:6257816	ENST00000457866	-	4	28	141_434	45.0	1197.0	HAP1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for AHI1-RPL22

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for AHI1-RPL22

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source