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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOCAD-HABP4 (FusionGDB2 ID:30999)

Fusion Gene Summary for FOCAD-HABP4

check button Fusion gene summary
Fusion gene informationFusion gene name: FOCAD-HABP4
Fusion gene ID: 30999
HgeneTgene
Gene symbol

FOCAD

HABP4

Gene ID

54914

22927

Gene namefocadhesinhyaluronan binding protein 4
SynonymsKIAA1797IHABP-4|IHABP4|Ki-1/57|SERBP1L
Cytomap

9p21.3

9q22.32

Type of geneprotein-codingprotein-coding
Descriptionfocadhesinintracellular hyaluronan-binding protein 4chromodomain helicase DNA binding protein 3 interacting proteinintracellular antigen detected by monoclonal antibody Ki-1ki-1/57 intracellular antigen
Modification date2020031320200313
UniProtAcc

Q5VW36

Q5JVS0

Ensembl transtripts involved in fusion geneENST00000338382, ENST00000380249, 
ENST00000604828, ENST00000605086, 
ENST00000466976, ENST00000375249, 
ENST00000375251, 
Fusion gene scores* DoF score16 X 12 X 11=21128 X 8 X 5=320
# samples 179
** MAII scorelog2(17/2112*10)=-3.63500318322075
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOCAD [Title/Abstract] AND HABP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOCAD(20789607)-HABP4(99250371), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHABP4

GO:0030578

PML body organization

28695742

TgeneHABP4

GO:0043392

negative regulation of DNA binding

15862299


check buttonFusion gene breakpoints across FOCAD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HABP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-QR-A70C-01AFOCADchr9

20789607

+HABP4chr9

99250371

+


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Fusion Gene ORF analysis for FOCAD-HABP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000338382ENST00000466976FOCADchr9

20789607

+HABP4chr9

99250371

+
5CDS-3UTRENST00000380249ENST00000466976FOCADchr9

20789607

+HABP4chr9

99250371

+
In-frameENST00000338382ENST00000375249FOCADchr9

20789607

+HABP4chr9

99250371

+
In-frameENST00000338382ENST00000375251FOCADchr9

20789607

+HABP4chr9

99250371

+
In-frameENST00000380249ENST00000375249FOCADchr9

20789607

+HABP4chr9

99250371

+
In-frameENST00000380249ENST00000375251FOCADchr9

20789607

+HABP4chr9

99250371

+
intron-3CDSENST00000604828ENST00000375249FOCADchr9

20789607

+HABP4chr9

99250371

+
intron-3CDSENST00000604828ENST00000375251FOCADchr9

20789607

+HABP4chr9

99250371

+
intron-3CDSENST00000605086ENST00000375249FOCADchr9

20789607

+HABP4chr9

99250371

+
intron-3CDSENST00000605086ENST00000375251FOCADchr9

20789607

+HABP4chr9

99250371

+
intron-3UTRENST00000604828ENST00000466976FOCADchr9

20789607

+HABP4chr9

99250371

+
intron-3UTRENST00000605086ENST00000466976FOCADchr9

20789607

+HABP4chr9

99250371

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380249FOCADchr920789607+ENST00000375251HABP4chr999250371+336018192322061609
ENST00000380249FOCADchr920789607+ENST00000375249HABP4chr999250371+336018192322061609
ENST00000338382FOCADchr920789607+ENST00000375251HABP4chr999250371+2996145501697565
ENST00000338382FOCADchr920789607+ENST00000375249HABP4chr999250371+2996145501697565

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380249ENST00000375251FOCADchr920789607+HABP4chr999250371+0.0043872530.99561274
ENST00000380249ENST00000375249FOCADchr920789607+HABP4chr999250371+0.0043872530.99561274
ENST00000338382ENST00000375251FOCADchr920789607+HABP4chr999250371+0.0031304980.9968695
ENST00000338382ENST00000375249FOCADchr920789607+HABP4chr999250371+0.0031304980.9968695

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Fusion Genomic Features for FOCAD-HABP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FOCADchr920789607+HABP4chr999250370+0.000343780.9996562
FOCADchr920789607+HABP4chr999250370+0.000343780.9996562

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FOCAD-HABP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:20789607/chr9:99250371)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOCAD

Q5VW36

HABP4

Q5JVS0

FUNCTION: Potential tumor suppressor in gliomas. {ECO:0000250, ECO:0000269|PubMed:22427331}.FUNCTION: RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOCADchr9:20789607chr9:99250371ENST00000338382+1043404_4244851802.0TransmembraneHelical
HgeneFOCADchr9:20789607chr9:99250371ENST00000338382+1043441_4614851802.0TransmembraneHelical
HgeneFOCADchr9:20789607chr9:99250371ENST00000380249+1346404_4244851802.0TransmembraneHelical
HgeneFOCADchr9:20789607chr9:99250371ENST00000380249+1346441_4614851802.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOCADchr9:20789607chr9:99250371ENST00000338382+10431036_10564851802.0TransmembraneHelical
HgeneFOCADchr9:20789607chr9:99250371ENST00000380249+13461036_10564851802.0TransmembraneHelical
TgeneHABP4chr9:20789607chr9:99250371ENST000003752495840_64333414.0Coiled coilOntology_term=ECO:0000255
TgeneHABP4chr9:20789607chr9:99250371ENST000003752512540_64228309.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for FOCAD-HABP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30999_30999_1_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000338382_HABP4_chr9_99250371_ENST00000375249_length(transcript)=2996nt_BP=1455nt
ATGTCAGATGATATCAGGAAAAGGTTTGAATTTCCAAATTCTCTTATCCAATCACAGGCTGTGGGTCATCTTATTGCTGCAGTCCTAAAG
GAAAATGGTTTTTCAGAAAAGATTCACCAATCTACAAATCAGACTCCTGCTTTGAACTTGCTGTGGGAGAAGTGTTGCAGTGACAATGTA
GTGGTTCGAACAGCCTGCTGTGAAGGTCTGGTGGCACTCGTTGCTCAGGATCATGCAGAGTTCAGCTATGTTCTCAATGGGATACTCAAC
TTGATTCCATCAACCAGAAATACACATGGCTTGATAAAAGCCATTATGCACTTACTACAAATGCAAGCTCTTAAGGAAGGACAAGGTGGG
GAAAAGAATATTCAGAGTATATATACCATTAGAAATCATCCTCATCCTTTGATAACTGTGCTTGAACACAGACCTGATTGCTGGCCAGTG
TTTTTGCAGCAGCTGACAGCGTTTTTCCAGCAGTGCCCTGAAAGGTTAGAAGTTTCATGCATTCAAATAATGGCACCATTTCTGTGGTAT
CTGTATTGTGAACCATCTCAGTTACAAGAATATGCTAAACTCCGACTAGCCCTGCTGAAAGTCTTACTTCAACCCCAGGTTCTTTGTGAC
AAAGATCAACCATCAATACTGGAACAGCAGATACTTCAACTGTGTTGTGACATAGTTCCATGTTTGCAGGTAAAAGATTTGATACAGACA
ACAGAGGCGATGATGTTTATTGAGGAAGTATGTTTAAGCCTTTTGCGTCATCCTGTTTTCTGGAAAATTCAGCTTACCCAGATGAGTCTT
CAGCTGCTGTGTGTCAGTGAAGTCAGCTTAAAGATAACTGGTGAATGTTCATCTTCAATTCACCTTTTAGAGCACAGTGTTGAACTTCTG
AAGGAGGATTTTCCTGTTGAACTGGTCATAATTGGAATAGCTTTACTACTTCTACAGACTCCAGCAAGTCAGCAGAAGCCAATCTTAAAT
CTAGCTTTGAAGCTCCTCTCTGTTACTGAGGATCAGAAAATCCCAAAGTCCTCTCTGCTGCTAGTGATGCCAATTCTGCAGATACTATCT
TCTACTGCCTTGGAAGACTGTATATCTGTGGATGAAGAAGGTCCCTCTAGGCAGCAGTTGGCTCTAAACCTTTTGGAAATGATACAGCAG
GAATGTTACAGAGATGACCACCAAAAGCTCTCCTACAAGCTTGTGTGCCCTGTAACCAGTATGTATGGTACAATATTTACAGCCTGGAGG
ATTCTTGAAGTAATGACAGACTCGTCTGCTGCAAGTGACTGGTTGGCTTCAGTAGAGTCATTGCTTCCTATTACTGCTGTGATCCCTGCG
CCTGCCTTTCTTCTGCTGGCTCACCTCCTTGTTGAAGACAAAGGACAAAATCTTCACCAAATACTCAAGGTCACTACAGAATTAGCCCAA
GCAGATTCCTCCCAGATGGTAAAAGATGACTATGAGGACGATTCCCATGTTTTCCGGAAACCCGCCAATGACATCACATCCCAGCTGGAG
ATTAATTTTGGTAACCTCCCTCGTCCTGGGCGTGGAGCCAGAGGAGGCACCCGGGGAGGCCGGGGAAGGATCAGGAGGGCAGAGAACTAT
GGACCCAGAGCAGAAGTGGTGATGCAAGATGTTGCCCCCAACCCAGATGACCCGGAAGATTTCCCTGCGCTGTCTTGAAAGAGCCCTGTT
TCCCAGCACCGCGGAGCTGCACTGCACACCTGTGGGGAGACTTTTCCAGCTGGGCCAAGGGAGTCAGACTCTAAGAACAATAGATGTTGC
TTTTCCCGTGTCATGTAAATTTGTTGCACTTTTTTGGGCTGAGCTGTTAGAGGGGCTTCTCCAGAGGCTCGAGAGCAGGCCATTTCCCAA
GAAGATGAAGAATGGTGACTGTGTTTTTATTGAAGGAATTTCAAATGAAGAATAATGTTTAAAATGTGTATATAGAGATAGTATAGACTC
CTCCGCGGAAGCATGGAGGGAAAGGAGGTTGTAAAATAGACTCCATGGAGACTCTTAGGAAGCAGTAGATTCCCGGGGGCTGTGCCTTTA
GCGTTAGAGGAAACACATAGAGCTGGAACTGTTAATGGAAAGCAGTCACAGCTGAGTTTTCGGAGACCAAGAAATTAAAATACAATTGCA
CTTACTGTTTACTTGTAAATGTTATCTTCTCTCCTGGAATATTTTGAGTTCTGGTTTTCACTTAACCAATCATTTAAAAATCGCTATTGT
GTAGCCACTGGCCACCACTCTGTGACACAGAATCAGAGAAAGCGTTGATTTTTAATGGTGATTTAAACTACCTCGTGGTTTCTGTGTGTG
TGCACACACACATCTAGTGTTTGGGTGGTTTTTAGGAAGAATATTAAGTATGTGACTTCAAAAACCATGTTATTTAACCTGCCAATCAAA
TGGAAAGGGATCATGGCAAAAGCAAATACCGCATCCTTTTCTTCCGCAGAACTAGAGTCAGAGTTCGGCAGCTGCGTACAAAGGCCTCTG
CCCTCGGCTTGAGCAAAAGTTGTAAATAACTAGTATTTATTAAGCACTTATAAGCAGTTTTTCTCACTTAGTCCTGGCTCCAGTTCTAGA
GTTCCTCTTTATTGCTTTTGGTGAAAGTTTGGGGTTGGGGGTACACCTCAGAGGTTCAGTAATTCACCTGGAGTCCCACCCTGAACAGAG
CTGGACCCAGAGCCACACACGCCCGGGAACACACACTGTGCTGGGGAGGAAGTGGGCCTAGGAGGGCCTGCAGGTCCAGGCAGCTGTAGA
GCTGCTAGAAGCTGGGGTGTTGCTCTCCCCGCTTTCTCATAGACACAGAGGTACTGTCTGCCTGTTGTCACACAGTTCATATGCTCGCTT
GAGATGGAATCTGAACCTTGGTCCCAGGATCTGTGCTTTTTCCCACTTTGCCACACTGTCTAAGGTGGCTTTGAACTGGAACCCAAGTGC

>30999_30999_1_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000338382_HABP4_chr9_99250371_ENST00000375249_length(amino acids)=565AA_BP=484
MSDDIRKRFEFPNSLIQSQAVGHLIAAVLKENGFSEKIHQSTNQTPALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAEFSYVLNGILN
LIPSTRNTHGLIKAIMHLLQMQALKEGQGGEKNIQSIYTIRNHPHPLITVLEHRPDCWPVFLQQLTAFFQQCPERLEVSCIQIMAPFLWY
LYCEPSQLQEYAKLRLALLKVLLQPQVLCDKDQPSILEQQILQLCCDIVPCLQVKDLIQTTEAMMFIEEVCLSLLRHPVFWKIQLTQMSL
QLLCVSEVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIGIALLLLQTPASQQKPILNLALKLLSVTEDQKIPKSSLLLVMPILQILS
STALEDCISVDEEGPSRQQLALNLLEMIQQECYRDDHQKLSYKLVCPVTSMYGTIFTAWRILEVMTDSSAASDWLASVESLLPITAVIPA
PAFLLLAHLLVEDKGQNLHQILKVTTELAQADSSQMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENY

--------------------------------------------------------------
>30999_30999_2_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000338382_HABP4_chr9_99250371_ENST00000375251_length(transcript)=2996nt_BP=1455nt
ATGTCAGATGATATCAGGAAAAGGTTTGAATTTCCAAATTCTCTTATCCAATCACAGGCTGTGGGTCATCTTATTGCTGCAGTCCTAAAG
GAAAATGGTTTTTCAGAAAAGATTCACCAATCTACAAATCAGACTCCTGCTTTGAACTTGCTGTGGGAGAAGTGTTGCAGTGACAATGTA
GTGGTTCGAACAGCCTGCTGTGAAGGTCTGGTGGCACTCGTTGCTCAGGATCATGCAGAGTTCAGCTATGTTCTCAATGGGATACTCAAC
TTGATTCCATCAACCAGAAATACACATGGCTTGATAAAAGCCATTATGCACTTACTACAAATGCAAGCTCTTAAGGAAGGACAAGGTGGG
GAAAAGAATATTCAGAGTATATATACCATTAGAAATCATCCTCATCCTTTGATAACTGTGCTTGAACACAGACCTGATTGCTGGCCAGTG
TTTTTGCAGCAGCTGACAGCGTTTTTCCAGCAGTGCCCTGAAAGGTTAGAAGTTTCATGCATTCAAATAATGGCACCATTTCTGTGGTAT
CTGTATTGTGAACCATCTCAGTTACAAGAATATGCTAAACTCCGACTAGCCCTGCTGAAAGTCTTACTTCAACCCCAGGTTCTTTGTGAC
AAAGATCAACCATCAATACTGGAACAGCAGATACTTCAACTGTGTTGTGACATAGTTCCATGTTTGCAGGTAAAAGATTTGATACAGACA
ACAGAGGCGATGATGTTTATTGAGGAAGTATGTTTAAGCCTTTTGCGTCATCCTGTTTTCTGGAAAATTCAGCTTACCCAGATGAGTCTT
CAGCTGCTGTGTGTCAGTGAAGTCAGCTTAAAGATAACTGGTGAATGTTCATCTTCAATTCACCTTTTAGAGCACAGTGTTGAACTTCTG
AAGGAGGATTTTCCTGTTGAACTGGTCATAATTGGAATAGCTTTACTACTTCTACAGACTCCAGCAAGTCAGCAGAAGCCAATCTTAAAT
CTAGCTTTGAAGCTCCTCTCTGTTACTGAGGATCAGAAAATCCCAAAGTCCTCTCTGCTGCTAGTGATGCCAATTCTGCAGATACTATCT
TCTACTGCCTTGGAAGACTGTATATCTGTGGATGAAGAAGGTCCCTCTAGGCAGCAGTTGGCTCTAAACCTTTTGGAAATGATACAGCAG
GAATGTTACAGAGATGACCACCAAAAGCTCTCCTACAAGCTTGTGTGCCCTGTAACCAGTATGTATGGTACAATATTTACAGCCTGGAGG
ATTCTTGAAGTAATGACAGACTCGTCTGCTGCAAGTGACTGGTTGGCTTCAGTAGAGTCATTGCTTCCTATTACTGCTGTGATCCCTGCG
CCTGCCTTTCTTCTGCTGGCTCACCTCCTTGTTGAAGACAAAGGACAAAATCTTCACCAAATACTCAAGGTCACTACAGAATTAGCCCAA
GCAGATTCCTCCCAGATGGTAAAAGATGACTATGAGGACGATTCCCATGTTTTCCGGAAACCCGCCAATGACATCACATCCCAGCTGGAG
ATTAATTTTGGTAACCTCCCTCGTCCTGGGCGTGGAGCCAGAGGAGGCACCCGGGGAGGCCGGGGAAGGATCAGGAGGGCAGAGAACTAT
GGACCCAGAGCAGAAGTGGTGATGCAAGATGTTGCCCCCAACCCAGATGACCCGGAAGATTTCCCTGCGCTGTCTTGAAAGAGCCCTGTT
TCCCAGCACCGCGGAGCTGCACTGCACACCTGTGGGGAGACTTTTCCAGCTGGGCCAAGGGAGTCAGACTCTAAGAACAATAGATGTTGC
TTTTCCCGTGTCATGTAAATTTGTTGCACTTTTTTGGGCTGAGCTGTTAGAGGGGCTTCTCCAGAGGCTCGAGAGCAGGCCATTTCCCAA
GAAGATGAAGAATGGTGACTGTGTTTTTATTGAAGGAATTTCAAATGAAGAATAATGTTTAAAATGTGTATATAGAGATAGTATAGACTC
CTCCGCGGAAGCATGGAGGGAAAGGAGGTTGTAAAATAGACTCCATGGAGACTCTTAGGAAGCAGTAGATTCCCGGGGGCTGTGCCTTTA
GCGTTAGAGGAAACACATAGAGCTGGAACTGTTAATGGAAAGCAGTCACAGCTGAGTTTTCGGAGACCAAGAAATTAAAATACAATTGCA
CTTACTGTTTACTTGTAAATGTTATCTTCTCTCCTGGAATATTTTGAGTTCTGGTTTTCACTTAACCAATCATTTAAAAATCGCTATTGT
GTAGCCACTGGCCACCACTCTGTGACACAGAATCAGAGAAAGCGTTGATTTTTAATGGTGATTTAAACTACCTCGTGGTTTCTGTGTGTG
TGCACACACACATCTAGTGTTTGGGTGGTTTTTAGGAAGAATATTAAGTATGTGACTTCAAAAACCATGTTATTTAACCTGCCAATCAAA
TGGAAAGGGATCATGGCAAAAGCAAATACCGCATCCTTTTCTTCCGCAGAACTAGAGTCAGAGTTCGGCAGCTGCGTACAAAGGCCTCTG
CCCTCGGCTTGAGCAAAAGTTGTAAATAACTAGTATTTATTAAGCACTTATAAGCAGTTTTTCTCACTTAGTCCTGGCTCCAGTTCTAGA
GTTCCTCTTTATTGCTTTTGGTGAAAGTTTGGGGTTGGGGGTACACCTCAGAGGTTCAGTAATTCACCTGGAGTCCCACCCTGAACAGAG
CTGGACCCAGAGCCACACACGCCCGGGAACACACACTGTGCTGGGGAGGAAGTGGGCCTAGGAGGGCCTGCAGGTCCAGGCAGCTGTAGA
GCTGCTAGAAGCTGGGGTGTTGCTCTCCCCGCTTTCTCATAGACACAGAGGTACTGTCTGCCTGTTGTCACACAGTTCATATGCTCGCTT
GAGATGGAATCTGAACCTTGGTCCCAGGATCTGTGCTTTTTCCCACTTTGCCACACTGTCTAAGGTGGCTTTGAACTGGAACCCAAGTGC

>30999_30999_2_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000338382_HABP4_chr9_99250371_ENST00000375251_length(amino acids)=565AA_BP=484
MSDDIRKRFEFPNSLIQSQAVGHLIAAVLKENGFSEKIHQSTNQTPALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAEFSYVLNGILN
LIPSTRNTHGLIKAIMHLLQMQALKEGQGGEKNIQSIYTIRNHPHPLITVLEHRPDCWPVFLQQLTAFFQQCPERLEVSCIQIMAPFLWY
LYCEPSQLQEYAKLRLALLKVLLQPQVLCDKDQPSILEQQILQLCCDIVPCLQVKDLIQTTEAMMFIEEVCLSLLRHPVFWKIQLTQMSL
QLLCVSEVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIGIALLLLQTPASQQKPILNLALKLLSVTEDQKIPKSSLLLVMPILQILS
STALEDCISVDEEGPSRQQLALNLLEMIQQECYRDDHQKLSYKLVCPVTSMYGTIFTAWRILEVMTDSSAASDWLASVESLLPITAVIPA
PAFLLLAHLLVEDKGQNLHQILKVTTELAQADSSQMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENY

--------------------------------------------------------------
>30999_30999_3_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000380249_HABP4_chr9_99250371_ENST00000375249_length(transcript)=3360nt_BP=1819nt
GTTCGAGCTTCCCGGCTGCTTTGTTTACCTAATCAAGCCTGGGCAATGGCGGGCGCCCCTCCCGCAGCCTCGCTGCCGCCTTGCAGGTTG
ATCTCAGACTGCTGTGCTAGCAATCAGTGAGACTCCGTGGGCGTAGGACTCTCCAAGCCAGTGAGATGAACTCGGTATCTCAGATGGAAA
TGCAGAAATCACCGTCTTCTCCATCGCTCACGCTGGGAGCTGTAGACCGGAGCTGTTCCTATTCGGCCATCTTTGCTCCTCCCTGCAACT
AACTCCATTCTTAATTGACCATCAAGGAAATTTCCATCCACACAGATTAGCAGTTGAAAATGAAGCTGCACACATACATGTAAGAGAAGC
AAAAATGTCAGATGATATCAGGAAAAGGTTTGAATTTCCAAATTCTCTTATCCAATCACAGGCTGTGGGTCATCTTATTGCTGCAGTCCT
AAAGGAAAATGGTTTTTCAGAAAAGATTCACCAATCTACAAATCAGACTCCTGCTTTGAACTTGCTGTGGGAGAAGTGTTGCAGTGACAA
TGTAGTGGTTCGAACAGCCTGCTGTGAAGGTCTGGTGGCACTCGTTGCTCAGGATCATGCAGAGTTCAGCTATGTTCTCAATGGGATACT
CAACTTGATTCCATCAACCAGAAATACACATGGCTTGATAAAAGCCATTATGCACTTACTACAAATGCAAGCTCTTAAGGAAGGACAAGG
TGGGGAAAAGAATATTCAGAGTATATATACCATTAGAAATCATCCTCATCCTTTGATAACTGTGCTTGAACACAGACCTGATTGCTGGCC
AGTGTTTTTGCAGCAGCTGACAGCGTTTTTCCAGCAGTGCCCTGAAAGGTTAGAAGTTTCATGCATTCAAATAATGGCACCATTTCTGTG
GTATCTGTATTGTGAACCATCTCAGTTACAAGAATATGCTAAACTCCGACTAGCCCTGCTGAAAGTCTTACTTCAACCCCAGGTTCTTTG
TGACAAAGATCAACCATCAATACTGGAACAGCAGATACTTCAACTGTGTTGTGACATAGTTCCATGTTTGCAGGTAAAAGATTTGATACA
GACAACAGAGGCGATGATGTTTATTGAGGAAGTATGTTTAAGCCTTTTGCGTCATCCTGTTTTCTGGAAAATTCAGCTTACCCAGATGAG
TCTTCAGCTGCTGTGTGTCAGTGAAGTCAGCTTAAAGATAACTGGTGAATGTTCATCTTCAATTCACCTTTTAGAGCACAGTGTTGAACT
TCTGAAGGAGGATTTTCCTGTTGAACTGGTCATAATTGGAATAGCTTTACTACTTCTACAGACTCCAGCAAGTCAGCAGAAGCCAATCTT
AAATCTAGCTTTGAAGCTCCTCTCTGTTACTGAGGATCAGAAAATCCCAAAGTCCTCTCTGCTGCTAGTGATGCCAATTCTGCAGATACT
ATCTTCTACTGCCTTGGAAGACTGTATATCTGTGGATGAAGAAGGTCCCTCTAGGCAGCAGTTGGCTCTAAACCTTTTGGAAATGATACA
GCAGGAATGTTACAGAGATGACCACCAAAAGCTCTCCTACAAGCTTGTGTGCCCTGTAACCAGTATGTATGGTACAATATTTACAGCCTG
GAGGATTCTTGAAGTAATGACAGACTCGTCTGCTGCAAGTGACTGGTTGGCTTCAGTAGAGTCATTGCTTCCTATTACTGCTGTGATCCC
TGCGCCTGCCTTTCTTCTGCTGGCTCACCTCCTTGTTGAAGACAAAGGACAAAATCTTCACCAAATACTCAAGGTCACTACAGAATTAGC
CCAAGCAGATTCCTCCCAGATGGTAAAAGATGACTATGAGGACGATTCCCATGTTTTCCGGAAACCCGCCAATGACATCACATCCCAGCT
GGAGATTAATTTTGGTAACCTCCCTCGTCCTGGGCGTGGAGCCAGAGGAGGCACCCGGGGAGGCCGGGGAAGGATCAGGAGGGCAGAGAA
CTATGGACCCAGAGCAGAAGTGGTGATGCAAGATGTTGCCCCCAACCCAGATGACCCGGAAGATTTCCCTGCGCTGTCTTGAAAGAGCCC
TGTTTCCCAGCACCGCGGAGCTGCACTGCACACCTGTGGGGAGACTTTTCCAGCTGGGCCAAGGGAGTCAGACTCTAAGAACAATAGATG
TTGCTTTTCCCGTGTCATGTAAATTTGTTGCACTTTTTTGGGCTGAGCTGTTAGAGGGGCTTCTCCAGAGGCTCGAGAGCAGGCCATTTC
CCAAGAAGATGAAGAATGGTGACTGTGTTTTTATTGAAGGAATTTCAAATGAAGAATAATGTTTAAAATGTGTATATAGAGATAGTATAG
ACTCCTCCGCGGAAGCATGGAGGGAAAGGAGGTTGTAAAATAGACTCCATGGAGACTCTTAGGAAGCAGTAGATTCCCGGGGGCTGTGCC
TTTAGCGTTAGAGGAAACACATAGAGCTGGAACTGTTAATGGAAAGCAGTCACAGCTGAGTTTTCGGAGACCAAGAAATTAAAATACAAT
TGCACTTACTGTTTACTTGTAAATGTTATCTTCTCTCCTGGAATATTTTGAGTTCTGGTTTTCACTTAACCAATCATTTAAAAATCGCTA
TTGTGTAGCCACTGGCCACCACTCTGTGACACAGAATCAGAGAAAGCGTTGATTTTTAATGGTGATTTAAACTACCTCGTGGTTTCTGTG
TGTGTGCACACACACATCTAGTGTTTGGGTGGTTTTTAGGAAGAATATTAAGTATGTGACTTCAAAAACCATGTTATTTAACCTGCCAAT
CAAATGGAAAGGGATCATGGCAAAAGCAAATACCGCATCCTTTTCTTCCGCAGAACTAGAGTCAGAGTTCGGCAGCTGCGTACAAAGGCC
TCTGCCCTCGGCTTGAGCAAAAGTTGTAAATAACTAGTATTTATTAAGCACTTATAAGCAGTTTTTCTCACTTAGTCCTGGCTCCAGTTC
TAGAGTTCCTCTTTATTGCTTTTGGTGAAAGTTTGGGGTTGGGGGTACACCTCAGAGGTTCAGTAATTCACCTGGAGTCCCACCCTGAAC
AGAGCTGGACCCAGAGCCACACACGCCCGGGAACACACACTGTGCTGGGGAGGAAGTGGGCCTAGGAGGGCCTGCAGGTCCAGGCAGCTG
TAGAGCTGCTAGAAGCTGGGGTGTTGCTCTCCCCGCTTTCTCATAGACACAGAGGTACTGTCTGCCTGTTGTCACACAGTTCATATGCTC
GCTTGAGATGGAATCTGAACCTTGGTCCCAGGATCTGTGCTTTTTCCCACTTTGCCACACTGTCTAAGGTGGCTTTGAACTGGAACCCAA

>30999_30999_3_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000380249_HABP4_chr9_99250371_ENST00000375249_length(amino acids)=609AA_BP=528
MFLFGHLCSSLQLTPFLIDHQGNFHPHRLAVENEAAHIHVREAKMSDDIRKRFEFPNSLIQSQAVGHLIAAVLKENGFSEKIHQSTNQTP
ALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAEFSYVLNGILNLIPSTRNTHGLIKAIMHLLQMQALKEGQGGEKNIQSIYTIRNHPHP
LITVLEHRPDCWPVFLQQLTAFFQQCPERLEVSCIQIMAPFLWYLYCEPSQLQEYAKLRLALLKVLLQPQVLCDKDQPSILEQQILQLCC
DIVPCLQVKDLIQTTEAMMFIEEVCLSLLRHPVFWKIQLTQMSLQLLCVSEVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIGIALL
LLQTPASQQKPILNLALKLLSVTEDQKIPKSSLLLVMPILQILSSTALEDCISVDEEGPSRQQLALNLLEMIQQECYRDDHQKLSYKLVC
PVTSMYGTIFTAWRILEVMTDSSAASDWLASVESLLPITAVIPAPAFLLLAHLLVEDKGQNLHQILKVTTELAQADSSQMVKDDYEDDSH

--------------------------------------------------------------
>30999_30999_4_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000380249_HABP4_chr9_99250371_ENST00000375251_length(transcript)=3360nt_BP=1819nt
GTTCGAGCTTCCCGGCTGCTTTGTTTACCTAATCAAGCCTGGGCAATGGCGGGCGCCCCTCCCGCAGCCTCGCTGCCGCCTTGCAGGTTG
ATCTCAGACTGCTGTGCTAGCAATCAGTGAGACTCCGTGGGCGTAGGACTCTCCAAGCCAGTGAGATGAACTCGGTATCTCAGATGGAAA
TGCAGAAATCACCGTCTTCTCCATCGCTCACGCTGGGAGCTGTAGACCGGAGCTGTTCCTATTCGGCCATCTTTGCTCCTCCCTGCAACT
AACTCCATTCTTAATTGACCATCAAGGAAATTTCCATCCACACAGATTAGCAGTTGAAAATGAAGCTGCACACATACATGTAAGAGAAGC
AAAAATGTCAGATGATATCAGGAAAAGGTTTGAATTTCCAAATTCTCTTATCCAATCACAGGCTGTGGGTCATCTTATTGCTGCAGTCCT
AAAGGAAAATGGTTTTTCAGAAAAGATTCACCAATCTACAAATCAGACTCCTGCTTTGAACTTGCTGTGGGAGAAGTGTTGCAGTGACAA
TGTAGTGGTTCGAACAGCCTGCTGTGAAGGTCTGGTGGCACTCGTTGCTCAGGATCATGCAGAGTTCAGCTATGTTCTCAATGGGATACT
CAACTTGATTCCATCAACCAGAAATACACATGGCTTGATAAAAGCCATTATGCACTTACTACAAATGCAAGCTCTTAAGGAAGGACAAGG
TGGGGAAAAGAATATTCAGAGTATATATACCATTAGAAATCATCCTCATCCTTTGATAACTGTGCTTGAACACAGACCTGATTGCTGGCC
AGTGTTTTTGCAGCAGCTGACAGCGTTTTTCCAGCAGTGCCCTGAAAGGTTAGAAGTTTCATGCATTCAAATAATGGCACCATTTCTGTG
GTATCTGTATTGTGAACCATCTCAGTTACAAGAATATGCTAAACTCCGACTAGCCCTGCTGAAAGTCTTACTTCAACCCCAGGTTCTTTG
TGACAAAGATCAACCATCAATACTGGAACAGCAGATACTTCAACTGTGTTGTGACATAGTTCCATGTTTGCAGGTAAAAGATTTGATACA
GACAACAGAGGCGATGATGTTTATTGAGGAAGTATGTTTAAGCCTTTTGCGTCATCCTGTTTTCTGGAAAATTCAGCTTACCCAGATGAG
TCTTCAGCTGCTGTGTGTCAGTGAAGTCAGCTTAAAGATAACTGGTGAATGTTCATCTTCAATTCACCTTTTAGAGCACAGTGTTGAACT
TCTGAAGGAGGATTTTCCTGTTGAACTGGTCATAATTGGAATAGCTTTACTACTTCTACAGACTCCAGCAAGTCAGCAGAAGCCAATCTT
AAATCTAGCTTTGAAGCTCCTCTCTGTTACTGAGGATCAGAAAATCCCAAAGTCCTCTCTGCTGCTAGTGATGCCAATTCTGCAGATACT
ATCTTCTACTGCCTTGGAAGACTGTATATCTGTGGATGAAGAAGGTCCCTCTAGGCAGCAGTTGGCTCTAAACCTTTTGGAAATGATACA
GCAGGAATGTTACAGAGATGACCACCAAAAGCTCTCCTACAAGCTTGTGTGCCCTGTAACCAGTATGTATGGTACAATATTTACAGCCTG
GAGGATTCTTGAAGTAATGACAGACTCGTCTGCTGCAAGTGACTGGTTGGCTTCAGTAGAGTCATTGCTTCCTATTACTGCTGTGATCCC
TGCGCCTGCCTTTCTTCTGCTGGCTCACCTCCTTGTTGAAGACAAAGGACAAAATCTTCACCAAATACTCAAGGTCACTACAGAATTAGC
CCAAGCAGATTCCTCCCAGATGGTAAAAGATGACTATGAGGACGATTCCCATGTTTTCCGGAAACCCGCCAATGACATCACATCCCAGCT
GGAGATTAATTTTGGTAACCTCCCTCGTCCTGGGCGTGGAGCCAGAGGAGGCACCCGGGGAGGCCGGGGAAGGATCAGGAGGGCAGAGAA
CTATGGACCCAGAGCAGAAGTGGTGATGCAAGATGTTGCCCCCAACCCAGATGACCCGGAAGATTTCCCTGCGCTGTCTTGAAAGAGCCC
TGTTTCCCAGCACCGCGGAGCTGCACTGCACACCTGTGGGGAGACTTTTCCAGCTGGGCCAAGGGAGTCAGACTCTAAGAACAATAGATG
TTGCTTTTCCCGTGTCATGTAAATTTGTTGCACTTTTTTGGGCTGAGCTGTTAGAGGGGCTTCTCCAGAGGCTCGAGAGCAGGCCATTTC
CCAAGAAGATGAAGAATGGTGACTGTGTTTTTATTGAAGGAATTTCAAATGAAGAATAATGTTTAAAATGTGTATATAGAGATAGTATAG
ACTCCTCCGCGGAAGCATGGAGGGAAAGGAGGTTGTAAAATAGACTCCATGGAGACTCTTAGGAAGCAGTAGATTCCCGGGGGCTGTGCC
TTTAGCGTTAGAGGAAACACATAGAGCTGGAACTGTTAATGGAAAGCAGTCACAGCTGAGTTTTCGGAGACCAAGAAATTAAAATACAAT
TGCACTTACTGTTTACTTGTAAATGTTATCTTCTCTCCTGGAATATTTTGAGTTCTGGTTTTCACTTAACCAATCATTTAAAAATCGCTA
TTGTGTAGCCACTGGCCACCACTCTGTGACACAGAATCAGAGAAAGCGTTGATTTTTAATGGTGATTTAAACTACCTCGTGGTTTCTGTG
TGTGTGCACACACACATCTAGTGTTTGGGTGGTTTTTAGGAAGAATATTAAGTATGTGACTTCAAAAACCATGTTATTTAACCTGCCAAT
CAAATGGAAAGGGATCATGGCAAAAGCAAATACCGCATCCTTTTCTTCCGCAGAACTAGAGTCAGAGTTCGGCAGCTGCGTACAAAGGCC
TCTGCCCTCGGCTTGAGCAAAAGTTGTAAATAACTAGTATTTATTAAGCACTTATAAGCAGTTTTTCTCACTTAGTCCTGGCTCCAGTTC
TAGAGTTCCTCTTTATTGCTTTTGGTGAAAGTTTGGGGTTGGGGGTACACCTCAGAGGTTCAGTAATTCACCTGGAGTCCCACCCTGAAC
AGAGCTGGACCCAGAGCCACACACGCCCGGGAACACACACTGTGCTGGGGAGGAAGTGGGCCTAGGAGGGCCTGCAGGTCCAGGCAGCTG
TAGAGCTGCTAGAAGCTGGGGTGTTGCTCTCCCCGCTTTCTCATAGACACAGAGGTACTGTCTGCCTGTTGTCACACAGTTCATATGCTC
GCTTGAGATGGAATCTGAACCTTGGTCCCAGGATCTGTGCTTTTTCCCACTTTGCCACACTGTCTAAGGTGGCTTTGAACTGGAACCCAA

>30999_30999_4_FOCAD-HABP4_FOCAD_chr9_20789607_ENST00000380249_HABP4_chr9_99250371_ENST00000375251_length(amino acids)=609AA_BP=528
MFLFGHLCSSLQLTPFLIDHQGNFHPHRLAVENEAAHIHVREAKMSDDIRKRFEFPNSLIQSQAVGHLIAAVLKENGFSEKIHQSTNQTP
ALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAEFSYVLNGILNLIPSTRNTHGLIKAIMHLLQMQALKEGQGGEKNIQSIYTIRNHPHP
LITVLEHRPDCWPVFLQQLTAFFQQCPERLEVSCIQIMAPFLWYLYCEPSQLQEYAKLRLALLKVLLQPQVLCDKDQPSILEQQILQLCC
DIVPCLQVKDLIQTTEAMMFIEEVCLSLLRHPVFWKIQLTQMSLQLLCVSEVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIGIALL
LLQTPASQQKPILNLALKLLSVTEDQKIPKSSLLLVMPILQILSSTALEDCISVDEEGPSRQQLALNLLEMIQQECYRDDHQKLSYKLVC
PVTSMYGTIFTAWRILEVMTDSSAASDWLASVESLLPITAVIPAPAFLLLAHLLVEDKGQNLHQILKVTTELAQADSSQMVKDDYEDDSH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FOCAD-HABP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOCAD-HABP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOCAD-HABP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource