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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOPNL-TMX3 (FusionGDB2 ID:31020)

Fusion Gene Summary for FOPNL-TMX3

check button Fusion gene summary
Fusion gene informationFusion gene name: FOPNL-TMX3
Fusion gene ID: 31020
HgeneTgene
Gene symbol

FOPNL

TMX3

Gene ID

123811

54495

Gene namecentrosomal protein 20thioredoxin related transmembrane protein 3
SynonymsC16orf63|FOPNL|FOR20|PHSECRG2PDIA13|TXNDC10
Cytomap

16p13.11

18q22.1

Type of geneprotein-codingprotein-coding
DescriptionlisH domain-containing protein FOPNLFGFR1OP N-terminal likeFOP-related protein of 20 kDalisH domain-containing protein C16orf63pluripotent embryonic stem cell-related proteinprotein disulfide-isomerase TMX3protein disulfide isomerase family A, member 13thioredoxin domain containing 10thioredoxin domain-containing protein 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000255759, ENST00000573429, 
ENST00000575744, ENST00000573396, 
ENST00000573968, ENST00000575073, 
ENST00000443099, ENST00000562706, 
ENST00000566887, ENST00000299608, 
Fusion gene scores* DoF score5 X 6 X 3=901 X 1 X 1=1
# samples 51
** MAII scorelog2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: FOPNL [Title/Abstract] AND TMX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOPNL(15967347)-TMX3(66369027), # samples:1
FOPNL(15967348)-TMX3(66369027), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMX3

GO:0018171

peptidyl-cysteine oxidation

15623505


check buttonFusion gene breakpoints across FOPNL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11AFOPNLchr16

15967347

-TMX3chr18

66369027

-
ChimerDB4Non-CancerTCGA-IN-8462-11AFOPNLchr16

15967348

-TMX3chr18

66369027

-


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Fusion Gene ORF analysis for FOPNL-TMX3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000255759ENST00000443099FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000255759ENST00000443099FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000255759ENST00000562706FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000255759ENST00000562706FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000255759ENST00000566887FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000255759ENST00000566887FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000573429ENST00000443099FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000573429ENST00000443099FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000573429ENST00000562706FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000573429ENST00000562706FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000573429ENST00000566887FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000573429ENST00000566887FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000575744ENST00000443099FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000575744ENST00000443099FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000575744ENST00000562706FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000575744ENST00000562706FOPNLchr16

15967348

-TMX3chr18

66369027

-
5CDS-intronENST00000575744ENST00000566887FOPNLchr16

15967347

-TMX3chr18

66369027

-
5CDS-intronENST00000575744ENST00000566887FOPNLchr16

15967348

-TMX3chr18

66369027

-
In-frameENST00000255759ENST00000299608FOPNLchr16

15967347

-TMX3chr18

66369027

-
In-frameENST00000255759ENST00000299608FOPNLchr16

15967348

-TMX3chr18

66369027

-
In-frameENST00000573429ENST00000299608FOPNLchr16

15967347

-TMX3chr18

66369027

-
In-frameENST00000573429ENST00000299608FOPNLchr16

15967348

-TMX3chr18

66369027

-
In-frameENST00000575744ENST00000299608FOPNLchr16

15967347

-TMX3chr18

66369027

-
In-frameENST00000575744ENST00000299608FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-3CDSENST00000573396ENST00000299608FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-3CDSENST00000573396ENST00000299608FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-3CDSENST00000573968ENST00000299608FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-3CDSENST00000573968ENST00000299608FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-3CDSENST00000575073ENST00000299608FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-3CDSENST00000575073ENST00000299608FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000573396ENST00000443099FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000573396ENST00000443099FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000573396ENST00000562706FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000573396ENST00000562706FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000573396ENST00000566887FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000573396ENST00000566887FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000573968ENST00000443099FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000573968ENST00000443099FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000573968ENST00000562706FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000573968ENST00000562706FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000573968ENST00000566887FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000573968ENST00000566887FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000575073ENST00000443099FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000575073ENST00000443099FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000575073ENST00000562706FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000575073ENST00000562706FOPNLchr16

15967348

-TMX3chr18

66369027

-
intron-intronENST00000575073ENST00000566887FOPNLchr16

15967347

-TMX3chr18

66369027

-
intron-intronENST00000575073ENST00000566887FOPNLchr16

15967348

-TMX3chr18

66369027

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000255759FOPNLchr1615967347-ENST00000299608TMX3chr1866369027-4823478301577515
ENST00000575744FOPNLchr1615967347-ENST00000299608TMX3chr1866369027-4613268181367449
ENST00000573429FOPNLchr1615967347-ENST00000299608TMX3chr1866369027-4894549291648539
ENST00000255759FOPNLchr1615967348-ENST00000299608TMX3chr1866369027-4823478301577515
ENST00000575744FOPNLchr1615967348-ENST00000299608TMX3chr1866369027-4613268181367449
ENST00000573429FOPNLchr1615967348-ENST00000299608TMX3chr1866369027-4894549291648539

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255759ENST00000299608FOPNLchr1615967347-TMX3chr1866369027-0.0001370690.9998629
ENST00000575744ENST00000299608FOPNLchr1615967347-TMX3chr1866369027-7.43E-050.99992573
ENST00000573429ENST00000299608FOPNLchr1615967347-TMX3chr1866369027-0.000156590.99984336
ENST00000255759ENST00000299608FOPNLchr1615967348-TMX3chr1866369027-0.0001370690.9998629
ENST00000575744ENST00000299608FOPNLchr1615967348-TMX3chr1866369027-7.43E-050.99992573
ENST00000573429ENST00000299608FOPNLchr1615967348-TMX3chr1866369027-0.000156590.99984336

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Fusion Genomic Features for FOPNL-TMX3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FOPNL-TMX3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:15967347/chr18:66369027)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOPNLchr16:15967347chr18:66369027ENST00000255759-4549_81149175.0DomainLisH
HgeneFOPNLchr16:15967348chr18:66369027ENST00000255759-4549_81149175.0DomainLisH
HgeneFOPNLchr16:15967347chr18:66369027ENST00000255759-451_104149175.0RegionNote=Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellites
HgeneFOPNLchr16:15967348chr18:66369027ENST00000255759-451_104149175.0RegionNote=Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellites
TgeneTMX3chr16:15967347chr18:66369027ENST00000299608316451_45488455.0MotifNote=Di-lysine motif
TgeneTMX3chr16:15967347chr18:66369027ENST0000056270638451_45488196.0MotifNote=Di-lysine motif
TgeneTMX3chr16:15967348chr18:66369027ENST00000299608316451_45488455.0MotifNote=Di-lysine motif
TgeneTMX3chr16:15967348chr18:66369027ENST0000056270638451_45488196.0MotifNote=Di-lysine motif
TgeneTMX3chr16:15967347chr18:66369027ENST00000299608316397_45488455.0Topological domainCytoplasmic
TgeneTMX3chr16:15967347chr18:66369027ENST0000056270638397_45488196.0Topological domainCytoplasmic
TgeneTMX3chr16:15967348chr18:66369027ENST00000299608316397_45488455.0Topological domainCytoplasmic
TgeneTMX3chr16:15967348chr18:66369027ENST0000056270638397_45488196.0Topological domainCytoplasmic
TgeneTMX3chr16:15967347chr18:66369027ENST00000299608316376_39688455.0TransmembraneHelical
TgeneTMX3chr16:15967347chr18:66369027ENST0000056270638376_39688196.0TransmembraneHelical
TgeneTMX3chr16:15967348chr18:66369027ENST00000299608316376_39688455.0TransmembraneHelical
TgeneTMX3chr16:15967348chr18:66369027ENST0000056270638376_39688196.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMX3chr16:15967347chr18:66369027ENST0000029960831625_12888455.0DomainThioredoxin
TgeneTMX3chr16:15967347chr18:66369027ENST000005627063825_12888196.0DomainThioredoxin
TgeneTMX3chr16:15967348chr18:66369027ENST0000029960831625_12888455.0DomainThioredoxin
TgeneTMX3chr16:15967348chr18:66369027ENST000005627063825_12888196.0DomainThioredoxin
TgeneTMX3chr16:15967347chr18:66369027ENST0000029960831625_37588455.0Topological domainLumenal
TgeneTMX3chr16:15967347chr18:66369027ENST000005627063825_37588196.0Topological domainLumenal
TgeneTMX3chr16:15967348chr18:66369027ENST0000029960831625_37588455.0Topological domainLumenal
TgeneTMX3chr16:15967348chr18:66369027ENST000005627063825_37588196.0Topological domainLumenal


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Fusion Gene Sequence for FOPNL-TMX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31020_31020_1_FOPNL-TMX3_FOPNL_chr16_15967347_ENST00000255759_TMX3_chr18_66369027_ENST00000299608_length(transcript)=4823nt_BP=478nt
CCGCGGTGCGGCCCTGGCGGCCGTTGAAAAATGGCGACTGTGGCAGAGTTGAAGGCTGTTTTAAAGGACACCTTGGAAAAAAAGGGGGTA
TTAGGGCATTTAAAAGCAAGGATCCGAGCTGAAGTTTTCAATGCCCTAGATGATGACCGTGAACCCCGACCATCATTGTCTCATGAAAAC
CTTCTAATTAATGAATTAATTCGAGAGTATTTAGAATTCAACAAATATAAGTATACAGCATCTGTCCTCATAGCAGAATCTGGTCAACCT
GTAGTTCCGTTGGACAGACAGTTTCTCATCCATGAACTAAATGCATTTGAAGAATCAAAGGATAATACAATACCTCTTTTATATGGGATT
TTAGCCCATTTCTTGCGTGGAACTAAGGATGGCATCCAGAATGCATTTCTGAAAGGGCCTTCACTTCAGCCTTCAGACCCAAGTCTTGGC
AGACAACCTAGTAGAAGAAAGCCAATGGGCATTGCTTCAGAGTTTGGAGTTCGAGGTTATCCAACAATTAAGCTATTAAAAGGGGACTTG
GCATATAATTATAGAGGACCACGAACAAAAGATGATATTATTGAGTTTGCTCACAGAGTATCTGGGGCTCTAATTCGGCCACTTCCAAGT
CAACAAATGTTTGAACATATGCAGAAGAGACACCGTGTATTTTTCGTTTATGTAGGTGGAGAATCACCTTTGAAAGAGAAATACATAGAT
GCTGCTTCAGAATTGATTGTATATACATACTTCTTTTCTGCCTCAGAAGAAGTGGTTCCTGAGTATGTGACACTAAAAGAGATGCCAGCT
GTGCTTGTTTTCAAAGATGAAACTTACTTTGTTTATGATGAGTATGAAGATGGTGATCTGTCATCATGGATCAACAGGGAAAGGTTTCAG
AATTACCTTGCTATGGATGGCTTCCTCTTGTATGAACTTGGAGACACAGGAAAGCTTGTGGCTCTTGCAGTTATTGATGAGAAAAATACA
TCAGTTGAACATACCAGATTGAAGTCAATTATTCAGGAAGTTGCAAGAGATTACAGAGACCTCTTCCATAGGGATTTTCAGTTTGGCCAC
ATGGATGGAAATGACTACATAAATACCTTGCTGATGGATGAATTGACAGTCCCAACTGTAGTTGTACTGAATACTTCAAACCAGCAATAT
TTCTTGCTAGATAGACAGATTAAGAATGTTGAAGACATGGTCCAGTTTATTAATAACATTTTGGATGGCACAGTAGAAGCCCAAGGAGGT
GATAGCATTTTGCAGAGATTGAAAAGAATAGTATTTGATGCCAAATCTACTATTGTGTCTATATTCAAGAGCTCACCACTGATGGGCTGC
TTTCTCTTTGGCCTGCCACTGGGTGTCATCAGTATCATGTGCTATGGAATCTACACAGCCGACACAGATGGAGGTTATATAGAAGAACGA
TATGAAGTGTCTAAAAGTGAAAATGAAAACCAAGAACAGATAGAAGAGAGCAAAGAACAGCAGGAGCCCAGCAGTGGAGGATCTGTAGTG
CCTACAGTGCAGGAGCCCAAGGATGTATTAGAAAAGAAGAAAGATTGAGACTTGATGACTATAAAATATTTGTTAGGACTTCAAATTATT
AAAGAGTCTATTTATTGAATTTAGACATTTAATCATGATCTTTACAGAAAAGAACATGTTATTCGTATTTTGCTAATATCAACTGCATGG
ATTAAAGTAGTCCCTCCATACATGGGGAAGTGTTTGGAGCAAAGAGATGAACAGTTTGTCTGAAACAAACACAGAGCACTCCATCAAAAT
TTACCTGATCTTTGTGATTAGAACAGAACAATTCTATTTGCATGTTTCTCTATCTGAATATTCTGTGACAAAAAGTTAAGATTCTTGGGC
AGAATATTTAAATTGGTCAGTCAGGTAGAAGATACATGTGTGATATAGAAAAATAATGCCTCTCCTGCTGCCATCCGTTTCCCTCATATA
TTTTGGACAAGATTTATATGGACAAAATTAAGTCTTTAAAATTTAGGCACTTTAAGGAGAACTAATAACTTTTTCCATGTATCAAGATTA
TGAGGTTAAAAATAATGTGGTTTTATATAGCATAGTGGTTTTATTTTGTTAGTTATTTTTAAAGGAGAAGAAATGTTACTTTTTAACTTT
ATACTCAGTTGCATTATCATAAAATTTTCATATATGCCTAGATAATGGGGAAAAAAAGTCTTGTGATTGACTTTCGCAAAATAAACAGGA
TTTACTGAGTAGAGGTTTCAGCCCATTCCTTGGAATACTAACAGGTATTTCATCAGTCATTGTAGGTTGGGAAGGGTCTCTGTTAATCCT
ACTCTGCTTTAGCCAGAATAGCCTAGTATTTTATTTCTATTTTATATATTGAGATTTCTTCTAACATTTCCTTTGATAAAAATCTTCTGC
TTTTTGAAAAGTGGTATGTATCATATTTTTATGTTTCTGGTGTGTGAACTTTATGGTAACTTCTACTCTAGAATACGTACGTATGCACCC
ACAGACACACACAGTTTATTGACACATCTATTATGTAATGCTGTAGACCTGTCCGTGTCTGCTTCATAAGGAGTAACGACTGACATTAGC
ATGTCCAGTGACAAGTCACATCCGGTGTAAAAAAAAGAGATCAGCCAGTTACCTTCTCCATTGTCTTAGTTCTGTCACCCATTTCGTCAA
GTGACCTCTCATCTTCTATAAACTAATACAGGAATTCTTTCCAAAGCAATGTCTAAAAACTCTTTTTTTTAAAGTAACAGTTTGGTATGT
TTATTGTAGATAAATTATTTTTGAGGCCTTCATTTTAGCTAAGTTTAGAATTTATATTAGGCAACTATGATTTGAGTGGTTATTCATTGA
GTAATTTTCCACTATAAAGAATTTTATTGAACATTTATTAAAAAATAATGTAATGCATGGTCAAAAAATATGTAATTCATGGTCTGGACA
CTGACGTTGTTTAGGGATTTAGTCATCAAGGACAGCCCTCTGTTGTTTCTAATGCCGTACTAATCAAGACTGTATGGACACTTGCATCTT
AAGTACTAAGGAATTACTAGTGATTGTTTTATTTTATCCATGTACTCTTTTAGTATTTAATAATTAAATACCTATTCTTAGTGTTTGACA
CTCCATATTTCTTTTTTTTGGAAATGAAACAAATATGCAGTCCAAAATTCAGGAACTACTAGAGTGAAATGATATTAAGTGGAAACCAGA
GATAAATGCTGTTAATTTAACAAGTAGATTCTTCTCCAAAGAATGATGAGTGATTCTTGGGAAGATAAATGTTAATGTTCCCAATAGTCA
AGCTTGTTTTGCAGTAGTGAAAAGCTTAGATGAGTACGGATACCTCATTTGAAACTCAGCCTAGTAAGGAAGTGAAAACTTAGCAGTCAG
TGACATGGGGAAATAGTTATAGAAAATGTCACTGAATTTTTTCATATTTATAATTAGTCATTTACATATTTTTGTCTTGTTGATCATTAC
CTGTAAATGAAAGACCTTAATAGGAAAAAAAGAGTAAAGCTCAGTGTGAATGCAAACATCCACAAAATATGATCTTCGTTTATATTCTGT
GATGTTGTTTATAAATGAATGCCTCAGTTCTCTGCTACCCTTTTCACAGCTTTGTACTGTTTGCCTTATATTCTATTTGTGCTTTTAAAG
TGTGTCTGTTGGGAAAACAAAATGTGTAGGTGGTTTGTAAGTGAATAATTTTTATTTCTTCTTGTATTAAAATTTTGTTTTTTTCTCTAC
TTTGGGAGATGTTTATTTACATTGTCAGACTATTCACAAAACAGATTCTAAAATTTGTTTGCTCGTATGCTGTTCCCTTCAATGTGATAT
CAGAGATTACTATGAATGTTAGTTTCATTCCGTGAAACATTACTTCCATATAAAGACAGATCTCTTAATAAGTGAATCTAGTGGAAGAAC
ATAGGTATCATTCTAATTCCATGGTAAATTTTGTCATGATTCTATATGAATAATGGGGTCCTTCAGGAAGTTGGAATTTTTGCCTTCTCT
TTTAATTGCAGTGAAGTTCTCTTTATAACTTCTAAAATTCGGAATTCTAGATCCTTGCTTTTGCAGAATTTGGTGCTCAGACAATATTTA
AGGACATTTCAGCGAGACAAAGTGCATGTTTTTATCGAGTACCCTGTGCACCACATTATATCTGGCAATTCTTTTTGTTTCATTATGTGC
ATCAATATTTTTCTCAGCTACTATTACCTGAAACTTGTTTAACATGTATTAGACCTAGAATTTTCATTTTCTTTCTCACATAGTTGCTTC
CTGGTATCTGATTTAGAAATAACATTTAAATGCCAAGTATCTGGGGGATTGAAGGAAGGGTCTATATGAGCAGGTGAATTAGCAGTACTG
TTTTTGTTTAGTGGATATTGTTAGTGACTTTTTGTGTGTGTTTTGCTTTGGGACCTTTTTATTTTGGTGTTGCAAAAAGTAACATATTTT
CATCATTGCTTCATACGACATGGAGTTAGGACAGGGAAAAATCATTCAACACTCCTTATGCATTAAATGATCAAATAAACCAGTGTAGGA
TATTAAGACTATCAATTGGTGGGATTAGGCTTGACATTTTATTTTTATAAATATATATTTTTTCTGAATGTGTCTGAGTCCAAGAGTGGG
CAAAAAATAATTTTCTACTTTGGACTAATCTATAGAGGTTTTTGAAAGTCTGCATTACTAACTTGTTGAATTCATGATATTCTGCCTATG

>31020_31020_1_FOPNL-TMX3_FOPNL_chr16_15967347_ENST00000255759_TMX3_chr18_66369027_ENST00000299608_length(amino acids)=515AA_BP=149
MATVAELKAVLKDTLEKKGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREYLEFNKYKYTASVLIAESGQPVVPLDRQFLI
HELNAFEESKDNTIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMGIASEFGVRGYPTIKLLKGDLAYNYRGPRTK
DDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYF
VYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTL
LMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVI

--------------------------------------------------------------
>31020_31020_2_FOPNL-TMX3_FOPNL_chr16_15967347_ENST00000573429_TMX3_chr18_66369027_ENST00000299608_length(transcript)=4894nt_BP=549nt
CGCGGTGCGGCCCTGGCGGCCGTTGAAAAATGGCGACTGTGGCAGAGTTGAAGGCTGTTTTAAAGGACACCTTGGAAAAAAAGGGGGTAT
TAGGGCATTTAAAAGCAAGGATCCGAGCTGAAGTTTTCAATGCCCTAGATGATGACCGTGAACCCCGACCATCATTGTCTCATGAAAACC
TTCTAATTAATGAATTAATTCGAGAGTATTTAGAATTCAACAAATATAAGTATACAGCATCTGTCCTCATAGCAGCTCACTGCATCCTCC
GCCTCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCCTCCCGAGTACCTGGAACTACAGAATCTGGTCAACCTGTAGTTCCGTTGGACAGAC
AGTTTCTCATCCATGAACTAAATGCATTTGAAGAATCAAAGGATAATACAATACCTCTTTTATATGGGATTTTAGCCCATTTCTTGCGTG
GAACTAAGGATGGCATCCAGAATGCATTTCTGAAAGGGCCTTCACTTCAGCCTTCAGACCCAAGTCTTGGCAGACAACCTAGTAGAAGAA
AGCCAATGGGCATTGCTTCAGAGTTTGGAGTTCGAGGTTATCCAACAATTAAGCTATTAAAAGGGGACTTGGCATATAATTATAGAGGAC
CACGAACAAAAGATGATATTATTGAGTTTGCTCACAGAGTATCTGGGGCTCTAATTCGGCCACTTCCAAGTCAACAAATGTTTGAACATA
TGCAGAAGAGACACCGTGTATTTTTCGTTTATGTAGGTGGAGAATCACCTTTGAAAGAGAAATACATAGATGCTGCTTCAGAATTGATTG
TATATACATACTTCTTTTCTGCCTCAGAAGAAGTGGTTCCTGAGTATGTGACACTAAAAGAGATGCCAGCTGTGCTTGTTTTCAAAGATG
AAACTTACTTTGTTTATGATGAGTATGAAGATGGTGATCTGTCATCATGGATCAACAGGGAAAGGTTTCAGAATTACCTTGCTATGGATG
GCTTCCTCTTGTATGAACTTGGAGACACAGGAAAGCTTGTGGCTCTTGCAGTTATTGATGAGAAAAATACATCAGTTGAACATACCAGAT
TGAAGTCAATTATTCAGGAAGTTGCAAGAGATTACAGAGACCTCTTCCATAGGGATTTTCAGTTTGGCCACATGGATGGAAATGACTACA
TAAATACCTTGCTGATGGATGAATTGACAGTCCCAACTGTAGTTGTACTGAATACTTCAAACCAGCAATATTTCTTGCTAGATAGACAGA
TTAAGAATGTTGAAGACATGGTCCAGTTTATTAATAACATTTTGGATGGCACAGTAGAAGCCCAAGGAGGTGATAGCATTTTGCAGAGAT
TGAAAAGAATAGTATTTGATGCCAAATCTACTATTGTGTCTATATTCAAGAGCTCACCACTGATGGGCTGCTTTCTCTTTGGCCTGCCAC
TGGGTGTCATCAGTATCATGTGCTATGGAATCTACACAGCCGACACAGATGGAGGTTATATAGAAGAACGATATGAAGTGTCTAAAAGTG
AAAATGAAAACCAAGAACAGATAGAAGAGAGCAAAGAACAGCAGGAGCCCAGCAGTGGAGGATCTGTAGTGCCTACAGTGCAGGAGCCCA
AGGATGTATTAGAAAAGAAGAAAGATTGAGACTTGATGACTATAAAATATTTGTTAGGACTTCAAATTATTAAAGAGTCTATTTATTGAA
TTTAGACATTTAATCATGATCTTTACAGAAAAGAACATGTTATTCGTATTTTGCTAATATCAACTGCATGGATTAAAGTAGTCCCTCCAT
ACATGGGGAAGTGTTTGGAGCAAAGAGATGAACAGTTTGTCTGAAACAAACACAGAGCACTCCATCAAAATTTACCTGATCTTTGTGATT
AGAACAGAACAATTCTATTTGCATGTTTCTCTATCTGAATATTCTGTGACAAAAAGTTAAGATTCTTGGGCAGAATATTTAAATTGGTCA
GTCAGGTAGAAGATACATGTGTGATATAGAAAAATAATGCCTCTCCTGCTGCCATCCGTTTCCCTCATATATTTTGGACAAGATTTATAT
GGACAAAATTAAGTCTTTAAAATTTAGGCACTTTAAGGAGAACTAATAACTTTTTCCATGTATCAAGATTATGAGGTTAAAAATAATGTG
GTTTTATATAGCATAGTGGTTTTATTTTGTTAGTTATTTTTAAAGGAGAAGAAATGTTACTTTTTAACTTTATACTCAGTTGCATTATCA
TAAAATTTTCATATATGCCTAGATAATGGGGAAAAAAAGTCTTGTGATTGACTTTCGCAAAATAAACAGGATTTACTGAGTAGAGGTTTC
AGCCCATTCCTTGGAATACTAACAGGTATTTCATCAGTCATTGTAGGTTGGGAAGGGTCTCTGTTAATCCTACTCTGCTTTAGCCAGAAT
AGCCTAGTATTTTATTTCTATTTTATATATTGAGATTTCTTCTAACATTTCCTTTGATAAAAATCTTCTGCTTTTTGAAAAGTGGTATGT
ATCATATTTTTATGTTTCTGGTGTGTGAACTTTATGGTAACTTCTACTCTAGAATACGTACGTATGCACCCACAGACACACACAGTTTAT
TGACACATCTATTATGTAATGCTGTAGACCTGTCCGTGTCTGCTTCATAAGGAGTAACGACTGACATTAGCATGTCCAGTGACAAGTCAC
ATCCGGTGTAAAAAAAAGAGATCAGCCAGTTACCTTCTCCATTGTCTTAGTTCTGTCACCCATTTCGTCAAGTGACCTCTCATCTTCTAT
AAACTAATACAGGAATTCTTTCCAAAGCAATGTCTAAAAACTCTTTTTTTTAAAGTAACAGTTTGGTATGTTTATTGTAGATAAATTATT
TTTGAGGCCTTCATTTTAGCTAAGTTTAGAATTTATATTAGGCAACTATGATTTGAGTGGTTATTCATTGAGTAATTTTCCACTATAAAG
AATTTTATTGAACATTTATTAAAAAATAATGTAATGCATGGTCAAAAAATATGTAATTCATGGTCTGGACACTGACGTTGTTTAGGGATT
TAGTCATCAAGGACAGCCCTCTGTTGTTTCTAATGCCGTACTAATCAAGACTGTATGGACACTTGCATCTTAAGTACTAAGGAATTACTA
GTGATTGTTTTATTTTATCCATGTACTCTTTTAGTATTTAATAATTAAATACCTATTCTTAGTGTTTGACACTCCATATTTCTTTTTTTT
GGAAATGAAACAAATATGCAGTCCAAAATTCAGGAACTACTAGAGTGAAATGATATTAAGTGGAAACCAGAGATAAATGCTGTTAATTTA
ACAAGTAGATTCTTCTCCAAAGAATGATGAGTGATTCTTGGGAAGATAAATGTTAATGTTCCCAATAGTCAAGCTTGTTTTGCAGTAGTG
AAAAGCTTAGATGAGTACGGATACCTCATTTGAAACTCAGCCTAGTAAGGAAGTGAAAACTTAGCAGTCAGTGACATGGGGAAATAGTTA
TAGAAAATGTCACTGAATTTTTTCATATTTATAATTAGTCATTTACATATTTTTGTCTTGTTGATCATTACCTGTAAATGAAAGACCTTA
ATAGGAAAAAAAGAGTAAAGCTCAGTGTGAATGCAAACATCCACAAAATATGATCTTCGTTTATATTCTGTGATGTTGTTTATAAATGAA
TGCCTCAGTTCTCTGCTACCCTTTTCACAGCTTTGTACTGTTTGCCTTATATTCTATTTGTGCTTTTAAAGTGTGTCTGTTGGGAAAACA
AAATGTGTAGGTGGTTTGTAAGTGAATAATTTTTATTTCTTCTTGTATTAAAATTTTGTTTTTTTCTCTACTTTGGGAGATGTTTATTTA
CATTGTCAGACTATTCACAAAACAGATTCTAAAATTTGTTTGCTCGTATGCTGTTCCCTTCAATGTGATATCAGAGATTACTATGAATGT
TAGTTTCATTCCGTGAAACATTACTTCCATATAAAGACAGATCTCTTAATAAGTGAATCTAGTGGAAGAACATAGGTATCATTCTAATTC
CATGGTAAATTTTGTCATGATTCTATATGAATAATGGGGTCCTTCAGGAAGTTGGAATTTTTGCCTTCTCTTTTAATTGCAGTGAAGTTC
TCTTTATAACTTCTAAAATTCGGAATTCTAGATCCTTGCTTTTGCAGAATTTGGTGCTCAGACAATATTTAAGGACATTTCAGCGAGACA
AAGTGCATGTTTTTATCGAGTACCCTGTGCACCACATTATATCTGGCAATTCTTTTTGTTTCATTATGTGCATCAATATTTTTCTCAGCT
ACTATTACCTGAAACTTGTTTAACATGTATTAGACCTAGAATTTTCATTTTCTTTCTCACATAGTTGCTTCCTGGTATCTGATTTAGAAA
TAACATTTAAATGCCAAGTATCTGGGGGATTGAAGGAAGGGTCTATATGAGCAGGTGAATTAGCAGTACTGTTTTTGTTTAGTGGATATT
GTTAGTGACTTTTTGTGTGTGTTTTGCTTTGGGACCTTTTTATTTTGGTGTTGCAAAAAGTAACATATTTTCATCATTGCTTCATACGAC
ATGGAGTTAGGACAGGGAAAAATCATTCAACACTCCTTATGCATTAAATGATCAAATAAACCAGTGTAGGATATTAAGACTATCAATTGG
TGGGATTAGGCTTGACATTTTATTTTTATAAATATATATTTTTTCTGAATGTGTCTGAGTCCAAGAGTGGGCAAAAAATAATTTTCTACT
TTGGACTAATCTATAGAGGTTTTTGAAAGTCTGCATTACTAACTTGTTGAATTCATGATATTCTGCCTATGGCACAAATTGTAAACCTTT

>31020_31020_2_FOPNL-TMX3_FOPNL_chr16_15967347_ENST00000573429_TMX3_chr18_66369027_ENST00000299608_length(amino acids)=539AA_BP=73
MATVAELKAVLKDTLEKKGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREYLEFNKYKYTASVLIAAHCILRLLGSSSSPA
SASRVPGTTESGQPVVPLDRQFLIHELNAFEESKDNTIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMGIASEFG
VRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASE
EVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVAR
DYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKS

--------------------------------------------------------------
>31020_31020_3_FOPNL-TMX3_FOPNL_chr16_15967347_ENST00000575744_TMX3_chr18_66369027_ENST00000299608_length(transcript)=4613nt_BP=268nt
CCTGGCGGCCGTTGAAAAATGGCGACTGTGGCAGAGTTGAAGGCTGAATCTGGTCAACCTGTAGTTCCGTTGGACAGACAGTTTCTCATC
CATGAACTAAATGCATTTGAAGAATCAAAGGATAATACAATACCTCTTTTATATGGGATTTTAGCCCATTTCTTGCGTGGAACTAAGGAT
GGCATCCAGAATGCATTTCTGAAAGGGCCTTCACTTCAGCCTTCAGACCCAAGTCTTGGCAGACAACCTAGTAGAAGAAAGCCAATGGGC
ATTGCTTCAGAGTTTGGAGTTCGAGGTTATCCAACAATTAAGCTATTAAAAGGGGACTTGGCATATAATTATAGAGGACCACGAACAAAA
GATGATATTATTGAGTTTGCTCACAGAGTATCTGGGGCTCTAATTCGGCCACTTCCAAGTCAACAAATGTTTGAACATATGCAGAAGAGA
CACCGTGTATTTTTCGTTTATGTAGGTGGAGAATCACCTTTGAAAGAGAAATACATAGATGCTGCTTCAGAATTGATTGTATATACATAC
TTCTTTTCTGCCTCAGAAGAAGTGGTTCCTGAGTATGTGACACTAAAAGAGATGCCAGCTGTGCTTGTTTTCAAAGATGAAACTTACTTT
GTTTATGATGAGTATGAAGATGGTGATCTGTCATCATGGATCAACAGGGAAAGGTTTCAGAATTACCTTGCTATGGATGGCTTCCTCTTG
TATGAACTTGGAGACACAGGAAAGCTTGTGGCTCTTGCAGTTATTGATGAGAAAAATACATCAGTTGAACATACCAGATTGAAGTCAATT
ATTCAGGAAGTTGCAAGAGATTACAGAGACCTCTTCCATAGGGATTTTCAGTTTGGCCACATGGATGGAAATGACTACATAAATACCTTG
CTGATGGATGAATTGACAGTCCCAACTGTAGTTGTACTGAATACTTCAAACCAGCAATATTTCTTGCTAGATAGACAGATTAAGAATGTT
GAAGACATGGTCCAGTTTATTAATAACATTTTGGATGGCACAGTAGAAGCCCAAGGAGGTGATAGCATTTTGCAGAGATTGAAAAGAATA
GTATTTGATGCCAAATCTACTATTGTGTCTATATTCAAGAGCTCACCACTGATGGGCTGCTTTCTCTTTGGCCTGCCACTGGGTGTCATC
AGTATCATGTGCTATGGAATCTACACAGCCGACACAGATGGAGGTTATATAGAAGAACGATATGAAGTGTCTAAAAGTGAAAATGAAAAC
CAAGAACAGATAGAAGAGAGCAAAGAACAGCAGGAGCCCAGCAGTGGAGGATCTGTAGTGCCTACAGTGCAGGAGCCCAAGGATGTATTA
GAAAAGAAGAAAGATTGAGACTTGATGACTATAAAATATTTGTTAGGACTTCAAATTATTAAAGAGTCTATTTATTGAATTTAGACATTT
AATCATGATCTTTACAGAAAAGAACATGTTATTCGTATTTTGCTAATATCAACTGCATGGATTAAAGTAGTCCCTCCATACATGGGGAAG
TGTTTGGAGCAAAGAGATGAACAGTTTGTCTGAAACAAACACAGAGCACTCCATCAAAATTTACCTGATCTTTGTGATTAGAACAGAACA
ATTCTATTTGCATGTTTCTCTATCTGAATATTCTGTGACAAAAAGTTAAGATTCTTGGGCAGAATATTTAAATTGGTCAGTCAGGTAGAA
GATACATGTGTGATATAGAAAAATAATGCCTCTCCTGCTGCCATCCGTTTCCCTCATATATTTTGGACAAGATTTATATGGACAAAATTA
AGTCTTTAAAATTTAGGCACTTTAAGGAGAACTAATAACTTTTTCCATGTATCAAGATTATGAGGTTAAAAATAATGTGGTTTTATATAG
CATAGTGGTTTTATTTTGTTAGTTATTTTTAAAGGAGAAGAAATGTTACTTTTTAACTTTATACTCAGTTGCATTATCATAAAATTTTCA
TATATGCCTAGATAATGGGGAAAAAAAGTCTTGTGATTGACTTTCGCAAAATAAACAGGATTTACTGAGTAGAGGTTTCAGCCCATTCCT
TGGAATACTAACAGGTATTTCATCAGTCATTGTAGGTTGGGAAGGGTCTCTGTTAATCCTACTCTGCTTTAGCCAGAATAGCCTAGTATT
TTATTTCTATTTTATATATTGAGATTTCTTCTAACATTTCCTTTGATAAAAATCTTCTGCTTTTTGAAAAGTGGTATGTATCATATTTTT
ATGTTTCTGGTGTGTGAACTTTATGGTAACTTCTACTCTAGAATACGTACGTATGCACCCACAGACACACACAGTTTATTGACACATCTA
TTATGTAATGCTGTAGACCTGTCCGTGTCTGCTTCATAAGGAGTAACGACTGACATTAGCATGTCCAGTGACAAGTCACATCCGGTGTAA
AAAAAAGAGATCAGCCAGTTACCTTCTCCATTGTCTTAGTTCTGTCACCCATTTCGTCAAGTGACCTCTCATCTTCTATAAACTAATACA
GGAATTCTTTCCAAAGCAATGTCTAAAAACTCTTTTTTTTAAAGTAACAGTTTGGTATGTTTATTGTAGATAAATTATTTTTGAGGCCTT
CATTTTAGCTAAGTTTAGAATTTATATTAGGCAACTATGATTTGAGTGGTTATTCATTGAGTAATTTTCCACTATAAAGAATTTTATTGA
ACATTTATTAAAAAATAATGTAATGCATGGTCAAAAAATATGTAATTCATGGTCTGGACACTGACGTTGTTTAGGGATTTAGTCATCAAG
GACAGCCCTCTGTTGTTTCTAATGCCGTACTAATCAAGACTGTATGGACACTTGCATCTTAAGTACTAAGGAATTACTAGTGATTGTTTT
ATTTTATCCATGTACTCTTTTAGTATTTAATAATTAAATACCTATTCTTAGTGTTTGACACTCCATATTTCTTTTTTTTGGAAATGAAAC
AAATATGCAGTCCAAAATTCAGGAACTACTAGAGTGAAATGATATTAAGTGGAAACCAGAGATAAATGCTGTTAATTTAACAAGTAGATT
CTTCTCCAAAGAATGATGAGTGATTCTTGGGAAGATAAATGTTAATGTTCCCAATAGTCAAGCTTGTTTTGCAGTAGTGAAAAGCTTAGA
TGAGTACGGATACCTCATTTGAAACTCAGCCTAGTAAGGAAGTGAAAACTTAGCAGTCAGTGACATGGGGAAATAGTTATAGAAAATGTC
ACTGAATTTTTTCATATTTATAATTAGTCATTTACATATTTTTGTCTTGTTGATCATTACCTGTAAATGAAAGACCTTAATAGGAAAAAA
AGAGTAAAGCTCAGTGTGAATGCAAACATCCACAAAATATGATCTTCGTTTATATTCTGTGATGTTGTTTATAAATGAATGCCTCAGTTC
TCTGCTACCCTTTTCACAGCTTTGTACTGTTTGCCTTATATTCTATTTGTGCTTTTAAAGTGTGTCTGTTGGGAAAACAAAATGTGTAGG
TGGTTTGTAAGTGAATAATTTTTATTTCTTCTTGTATTAAAATTTTGTTTTTTTCTCTACTTTGGGAGATGTTTATTTACATTGTCAGAC
TATTCACAAAACAGATTCTAAAATTTGTTTGCTCGTATGCTGTTCCCTTCAATGTGATATCAGAGATTACTATGAATGTTAGTTTCATTC
CGTGAAACATTACTTCCATATAAAGACAGATCTCTTAATAAGTGAATCTAGTGGAAGAACATAGGTATCATTCTAATTCCATGGTAAATT
TTGTCATGATTCTATATGAATAATGGGGTCCTTCAGGAAGTTGGAATTTTTGCCTTCTCTTTTAATTGCAGTGAAGTTCTCTTTATAACT
TCTAAAATTCGGAATTCTAGATCCTTGCTTTTGCAGAATTTGGTGCTCAGACAATATTTAAGGACATTTCAGCGAGACAAAGTGCATGTT
TTTATCGAGTACCCTGTGCACCACATTATATCTGGCAATTCTTTTTGTTTCATTATGTGCATCAATATTTTTCTCAGCTACTATTACCTG
AAACTTGTTTAACATGTATTAGACCTAGAATTTTCATTTTCTTTCTCACATAGTTGCTTCCTGGTATCTGATTTAGAAATAACATTTAAA
TGCCAAGTATCTGGGGGATTGAAGGAAGGGTCTATATGAGCAGGTGAATTAGCAGTACTGTTTTTGTTTAGTGGATATTGTTAGTGACTT
TTTGTGTGTGTTTTGCTTTGGGACCTTTTTATTTTGGTGTTGCAAAAAGTAACATATTTTCATCATTGCTTCATACGACATGGAGTTAGG
ACAGGGAAAAATCATTCAACACTCCTTATGCATTAAATGATCAAATAAACCAGTGTAGGATATTAAGACTATCAATTGGTGGGATTAGGC
TTGACATTTTATTTTTATAAATATATATTTTTTCTGAATGTGTCTGAGTCCAAGAGTGGGCAAAAAATAATTTTCTACTTTGGACTAATC
TATAGAGGTTTTTGAAAGTCTGCATTACTAACTTGTTGAATTCATGATATTCTGCCTATGGCACAAATTGTAAACCTTTGTTTTTCTAAA

>31020_31020_3_FOPNL-TMX3_FOPNL_chr16_15967347_ENST00000575744_TMX3_chr18_66369027_ENST00000299608_length(amino acids)=449AA_BP=83
MATVAELKAESGQPVVPLDRQFLIHELNAFEESKDNTIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMGIASEFG
VRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASE
EVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVAR
DYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKS

--------------------------------------------------------------
>31020_31020_4_FOPNL-TMX3_FOPNL_chr16_15967348_ENST00000255759_TMX3_chr18_66369027_ENST00000299608_length(transcript)=4823nt_BP=478nt
CCGCGGTGCGGCCCTGGCGGCCGTTGAAAAATGGCGACTGTGGCAGAGTTGAAGGCTGTTTTAAAGGACACCTTGGAAAAAAAGGGGGTA
TTAGGGCATTTAAAAGCAAGGATCCGAGCTGAAGTTTTCAATGCCCTAGATGATGACCGTGAACCCCGACCATCATTGTCTCATGAAAAC
CTTCTAATTAATGAATTAATTCGAGAGTATTTAGAATTCAACAAATATAAGTATACAGCATCTGTCCTCATAGCAGAATCTGGTCAACCT
GTAGTTCCGTTGGACAGACAGTTTCTCATCCATGAACTAAATGCATTTGAAGAATCAAAGGATAATACAATACCTCTTTTATATGGGATT
TTAGCCCATTTCTTGCGTGGAACTAAGGATGGCATCCAGAATGCATTTCTGAAAGGGCCTTCACTTCAGCCTTCAGACCCAAGTCTTGGC
AGACAACCTAGTAGAAGAAAGCCAATGGGCATTGCTTCAGAGTTTGGAGTTCGAGGTTATCCAACAATTAAGCTATTAAAAGGGGACTTG
GCATATAATTATAGAGGACCACGAACAAAAGATGATATTATTGAGTTTGCTCACAGAGTATCTGGGGCTCTAATTCGGCCACTTCCAAGT
CAACAAATGTTTGAACATATGCAGAAGAGACACCGTGTATTTTTCGTTTATGTAGGTGGAGAATCACCTTTGAAAGAGAAATACATAGAT
GCTGCTTCAGAATTGATTGTATATACATACTTCTTTTCTGCCTCAGAAGAAGTGGTTCCTGAGTATGTGACACTAAAAGAGATGCCAGCT
GTGCTTGTTTTCAAAGATGAAACTTACTTTGTTTATGATGAGTATGAAGATGGTGATCTGTCATCATGGATCAACAGGGAAAGGTTTCAG
AATTACCTTGCTATGGATGGCTTCCTCTTGTATGAACTTGGAGACACAGGAAAGCTTGTGGCTCTTGCAGTTATTGATGAGAAAAATACA
TCAGTTGAACATACCAGATTGAAGTCAATTATTCAGGAAGTTGCAAGAGATTACAGAGACCTCTTCCATAGGGATTTTCAGTTTGGCCAC
ATGGATGGAAATGACTACATAAATACCTTGCTGATGGATGAATTGACAGTCCCAACTGTAGTTGTACTGAATACTTCAAACCAGCAATAT
TTCTTGCTAGATAGACAGATTAAGAATGTTGAAGACATGGTCCAGTTTATTAATAACATTTTGGATGGCACAGTAGAAGCCCAAGGAGGT
GATAGCATTTTGCAGAGATTGAAAAGAATAGTATTTGATGCCAAATCTACTATTGTGTCTATATTCAAGAGCTCACCACTGATGGGCTGC
TTTCTCTTTGGCCTGCCACTGGGTGTCATCAGTATCATGTGCTATGGAATCTACACAGCCGACACAGATGGAGGTTATATAGAAGAACGA
TATGAAGTGTCTAAAAGTGAAAATGAAAACCAAGAACAGATAGAAGAGAGCAAAGAACAGCAGGAGCCCAGCAGTGGAGGATCTGTAGTG
CCTACAGTGCAGGAGCCCAAGGATGTATTAGAAAAGAAGAAAGATTGAGACTTGATGACTATAAAATATTTGTTAGGACTTCAAATTATT
AAAGAGTCTATTTATTGAATTTAGACATTTAATCATGATCTTTACAGAAAAGAACATGTTATTCGTATTTTGCTAATATCAACTGCATGG
ATTAAAGTAGTCCCTCCATACATGGGGAAGTGTTTGGAGCAAAGAGATGAACAGTTTGTCTGAAACAAACACAGAGCACTCCATCAAAAT
TTACCTGATCTTTGTGATTAGAACAGAACAATTCTATTTGCATGTTTCTCTATCTGAATATTCTGTGACAAAAAGTTAAGATTCTTGGGC
AGAATATTTAAATTGGTCAGTCAGGTAGAAGATACATGTGTGATATAGAAAAATAATGCCTCTCCTGCTGCCATCCGTTTCCCTCATATA
TTTTGGACAAGATTTATATGGACAAAATTAAGTCTTTAAAATTTAGGCACTTTAAGGAGAACTAATAACTTTTTCCATGTATCAAGATTA
TGAGGTTAAAAATAATGTGGTTTTATATAGCATAGTGGTTTTATTTTGTTAGTTATTTTTAAAGGAGAAGAAATGTTACTTTTTAACTTT
ATACTCAGTTGCATTATCATAAAATTTTCATATATGCCTAGATAATGGGGAAAAAAAGTCTTGTGATTGACTTTCGCAAAATAAACAGGA
TTTACTGAGTAGAGGTTTCAGCCCATTCCTTGGAATACTAACAGGTATTTCATCAGTCATTGTAGGTTGGGAAGGGTCTCTGTTAATCCT
ACTCTGCTTTAGCCAGAATAGCCTAGTATTTTATTTCTATTTTATATATTGAGATTTCTTCTAACATTTCCTTTGATAAAAATCTTCTGC
TTTTTGAAAAGTGGTATGTATCATATTTTTATGTTTCTGGTGTGTGAACTTTATGGTAACTTCTACTCTAGAATACGTACGTATGCACCC
ACAGACACACACAGTTTATTGACACATCTATTATGTAATGCTGTAGACCTGTCCGTGTCTGCTTCATAAGGAGTAACGACTGACATTAGC
ATGTCCAGTGACAAGTCACATCCGGTGTAAAAAAAAGAGATCAGCCAGTTACCTTCTCCATTGTCTTAGTTCTGTCACCCATTTCGTCAA
GTGACCTCTCATCTTCTATAAACTAATACAGGAATTCTTTCCAAAGCAATGTCTAAAAACTCTTTTTTTTAAAGTAACAGTTTGGTATGT
TTATTGTAGATAAATTATTTTTGAGGCCTTCATTTTAGCTAAGTTTAGAATTTATATTAGGCAACTATGATTTGAGTGGTTATTCATTGA
GTAATTTTCCACTATAAAGAATTTTATTGAACATTTATTAAAAAATAATGTAATGCATGGTCAAAAAATATGTAATTCATGGTCTGGACA
CTGACGTTGTTTAGGGATTTAGTCATCAAGGACAGCCCTCTGTTGTTTCTAATGCCGTACTAATCAAGACTGTATGGACACTTGCATCTT
AAGTACTAAGGAATTACTAGTGATTGTTTTATTTTATCCATGTACTCTTTTAGTATTTAATAATTAAATACCTATTCTTAGTGTTTGACA
CTCCATATTTCTTTTTTTTGGAAATGAAACAAATATGCAGTCCAAAATTCAGGAACTACTAGAGTGAAATGATATTAAGTGGAAACCAGA
GATAAATGCTGTTAATTTAACAAGTAGATTCTTCTCCAAAGAATGATGAGTGATTCTTGGGAAGATAAATGTTAATGTTCCCAATAGTCA
AGCTTGTTTTGCAGTAGTGAAAAGCTTAGATGAGTACGGATACCTCATTTGAAACTCAGCCTAGTAAGGAAGTGAAAACTTAGCAGTCAG
TGACATGGGGAAATAGTTATAGAAAATGTCACTGAATTTTTTCATATTTATAATTAGTCATTTACATATTTTTGTCTTGTTGATCATTAC
CTGTAAATGAAAGACCTTAATAGGAAAAAAAGAGTAAAGCTCAGTGTGAATGCAAACATCCACAAAATATGATCTTCGTTTATATTCTGT
GATGTTGTTTATAAATGAATGCCTCAGTTCTCTGCTACCCTTTTCACAGCTTTGTACTGTTTGCCTTATATTCTATTTGTGCTTTTAAAG
TGTGTCTGTTGGGAAAACAAAATGTGTAGGTGGTTTGTAAGTGAATAATTTTTATTTCTTCTTGTATTAAAATTTTGTTTTTTTCTCTAC
TTTGGGAGATGTTTATTTACATTGTCAGACTATTCACAAAACAGATTCTAAAATTTGTTTGCTCGTATGCTGTTCCCTTCAATGTGATAT
CAGAGATTACTATGAATGTTAGTTTCATTCCGTGAAACATTACTTCCATATAAAGACAGATCTCTTAATAAGTGAATCTAGTGGAAGAAC
ATAGGTATCATTCTAATTCCATGGTAAATTTTGTCATGATTCTATATGAATAATGGGGTCCTTCAGGAAGTTGGAATTTTTGCCTTCTCT
TTTAATTGCAGTGAAGTTCTCTTTATAACTTCTAAAATTCGGAATTCTAGATCCTTGCTTTTGCAGAATTTGGTGCTCAGACAATATTTA
AGGACATTTCAGCGAGACAAAGTGCATGTTTTTATCGAGTACCCTGTGCACCACATTATATCTGGCAATTCTTTTTGTTTCATTATGTGC
ATCAATATTTTTCTCAGCTACTATTACCTGAAACTTGTTTAACATGTATTAGACCTAGAATTTTCATTTTCTTTCTCACATAGTTGCTTC
CTGGTATCTGATTTAGAAATAACATTTAAATGCCAAGTATCTGGGGGATTGAAGGAAGGGTCTATATGAGCAGGTGAATTAGCAGTACTG
TTTTTGTTTAGTGGATATTGTTAGTGACTTTTTGTGTGTGTTTTGCTTTGGGACCTTTTTATTTTGGTGTTGCAAAAAGTAACATATTTT
CATCATTGCTTCATACGACATGGAGTTAGGACAGGGAAAAATCATTCAACACTCCTTATGCATTAAATGATCAAATAAACCAGTGTAGGA
TATTAAGACTATCAATTGGTGGGATTAGGCTTGACATTTTATTTTTATAAATATATATTTTTTCTGAATGTGTCTGAGTCCAAGAGTGGG
CAAAAAATAATTTTCTACTTTGGACTAATCTATAGAGGTTTTTGAAAGTCTGCATTACTAACTTGTTGAATTCATGATATTCTGCCTATG

>31020_31020_4_FOPNL-TMX3_FOPNL_chr16_15967348_ENST00000255759_TMX3_chr18_66369027_ENST00000299608_length(amino acids)=515AA_BP=149
MATVAELKAVLKDTLEKKGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREYLEFNKYKYTASVLIAESGQPVVPLDRQFLI
HELNAFEESKDNTIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMGIASEFGVRGYPTIKLLKGDLAYNYRGPRTK
DDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYF
VYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTL
LMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVI

--------------------------------------------------------------
>31020_31020_5_FOPNL-TMX3_FOPNL_chr16_15967348_ENST00000573429_TMX3_chr18_66369027_ENST00000299608_length(transcript)=4894nt_BP=549nt
CGCGGTGCGGCCCTGGCGGCCGTTGAAAAATGGCGACTGTGGCAGAGTTGAAGGCTGTTTTAAAGGACACCTTGGAAAAAAAGGGGGTAT
TAGGGCATTTAAAAGCAAGGATCCGAGCTGAAGTTTTCAATGCCCTAGATGATGACCGTGAACCCCGACCATCATTGTCTCATGAAAACC
TTCTAATTAATGAATTAATTCGAGAGTATTTAGAATTCAACAAATATAAGTATACAGCATCTGTCCTCATAGCAGCTCACTGCATCCTCC
GCCTCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCCTCCCGAGTACCTGGAACTACAGAATCTGGTCAACCTGTAGTTCCGTTGGACAGAC
AGTTTCTCATCCATGAACTAAATGCATTTGAAGAATCAAAGGATAATACAATACCTCTTTTATATGGGATTTTAGCCCATTTCTTGCGTG
GAACTAAGGATGGCATCCAGAATGCATTTCTGAAAGGGCCTTCACTTCAGCCTTCAGACCCAAGTCTTGGCAGACAACCTAGTAGAAGAA
AGCCAATGGGCATTGCTTCAGAGTTTGGAGTTCGAGGTTATCCAACAATTAAGCTATTAAAAGGGGACTTGGCATATAATTATAGAGGAC
CACGAACAAAAGATGATATTATTGAGTTTGCTCACAGAGTATCTGGGGCTCTAATTCGGCCACTTCCAAGTCAACAAATGTTTGAACATA
TGCAGAAGAGACACCGTGTATTTTTCGTTTATGTAGGTGGAGAATCACCTTTGAAAGAGAAATACATAGATGCTGCTTCAGAATTGATTG
TATATACATACTTCTTTTCTGCCTCAGAAGAAGTGGTTCCTGAGTATGTGACACTAAAAGAGATGCCAGCTGTGCTTGTTTTCAAAGATG
AAACTTACTTTGTTTATGATGAGTATGAAGATGGTGATCTGTCATCATGGATCAACAGGGAAAGGTTTCAGAATTACCTTGCTATGGATG
GCTTCCTCTTGTATGAACTTGGAGACACAGGAAAGCTTGTGGCTCTTGCAGTTATTGATGAGAAAAATACATCAGTTGAACATACCAGAT
TGAAGTCAATTATTCAGGAAGTTGCAAGAGATTACAGAGACCTCTTCCATAGGGATTTTCAGTTTGGCCACATGGATGGAAATGACTACA
TAAATACCTTGCTGATGGATGAATTGACAGTCCCAACTGTAGTTGTACTGAATACTTCAAACCAGCAATATTTCTTGCTAGATAGACAGA
TTAAGAATGTTGAAGACATGGTCCAGTTTATTAATAACATTTTGGATGGCACAGTAGAAGCCCAAGGAGGTGATAGCATTTTGCAGAGAT
TGAAAAGAATAGTATTTGATGCCAAATCTACTATTGTGTCTATATTCAAGAGCTCACCACTGATGGGCTGCTTTCTCTTTGGCCTGCCAC
TGGGTGTCATCAGTATCATGTGCTATGGAATCTACACAGCCGACACAGATGGAGGTTATATAGAAGAACGATATGAAGTGTCTAAAAGTG
AAAATGAAAACCAAGAACAGATAGAAGAGAGCAAAGAACAGCAGGAGCCCAGCAGTGGAGGATCTGTAGTGCCTACAGTGCAGGAGCCCA
AGGATGTATTAGAAAAGAAGAAAGATTGAGACTTGATGACTATAAAATATTTGTTAGGACTTCAAATTATTAAAGAGTCTATTTATTGAA
TTTAGACATTTAATCATGATCTTTACAGAAAAGAACATGTTATTCGTATTTTGCTAATATCAACTGCATGGATTAAAGTAGTCCCTCCAT
ACATGGGGAAGTGTTTGGAGCAAAGAGATGAACAGTTTGTCTGAAACAAACACAGAGCACTCCATCAAAATTTACCTGATCTTTGTGATT
AGAACAGAACAATTCTATTTGCATGTTTCTCTATCTGAATATTCTGTGACAAAAAGTTAAGATTCTTGGGCAGAATATTTAAATTGGTCA
GTCAGGTAGAAGATACATGTGTGATATAGAAAAATAATGCCTCTCCTGCTGCCATCCGTTTCCCTCATATATTTTGGACAAGATTTATAT
GGACAAAATTAAGTCTTTAAAATTTAGGCACTTTAAGGAGAACTAATAACTTTTTCCATGTATCAAGATTATGAGGTTAAAAATAATGTG
GTTTTATATAGCATAGTGGTTTTATTTTGTTAGTTATTTTTAAAGGAGAAGAAATGTTACTTTTTAACTTTATACTCAGTTGCATTATCA
TAAAATTTTCATATATGCCTAGATAATGGGGAAAAAAAGTCTTGTGATTGACTTTCGCAAAATAAACAGGATTTACTGAGTAGAGGTTTC
AGCCCATTCCTTGGAATACTAACAGGTATTTCATCAGTCATTGTAGGTTGGGAAGGGTCTCTGTTAATCCTACTCTGCTTTAGCCAGAAT
AGCCTAGTATTTTATTTCTATTTTATATATTGAGATTTCTTCTAACATTTCCTTTGATAAAAATCTTCTGCTTTTTGAAAAGTGGTATGT
ATCATATTTTTATGTTTCTGGTGTGTGAACTTTATGGTAACTTCTACTCTAGAATACGTACGTATGCACCCACAGACACACACAGTTTAT
TGACACATCTATTATGTAATGCTGTAGACCTGTCCGTGTCTGCTTCATAAGGAGTAACGACTGACATTAGCATGTCCAGTGACAAGTCAC
ATCCGGTGTAAAAAAAAGAGATCAGCCAGTTACCTTCTCCATTGTCTTAGTTCTGTCACCCATTTCGTCAAGTGACCTCTCATCTTCTAT
AAACTAATACAGGAATTCTTTCCAAAGCAATGTCTAAAAACTCTTTTTTTTAAAGTAACAGTTTGGTATGTTTATTGTAGATAAATTATT
TTTGAGGCCTTCATTTTAGCTAAGTTTAGAATTTATATTAGGCAACTATGATTTGAGTGGTTATTCATTGAGTAATTTTCCACTATAAAG
AATTTTATTGAACATTTATTAAAAAATAATGTAATGCATGGTCAAAAAATATGTAATTCATGGTCTGGACACTGACGTTGTTTAGGGATT
TAGTCATCAAGGACAGCCCTCTGTTGTTTCTAATGCCGTACTAATCAAGACTGTATGGACACTTGCATCTTAAGTACTAAGGAATTACTA
GTGATTGTTTTATTTTATCCATGTACTCTTTTAGTATTTAATAATTAAATACCTATTCTTAGTGTTTGACACTCCATATTTCTTTTTTTT
GGAAATGAAACAAATATGCAGTCCAAAATTCAGGAACTACTAGAGTGAAATGATATTAAGTGGAAACCAGAGATAAATGCTGTTAATTTA
ACAAGTAGATTCTTCTCCAAAGAATGATGAGTGATTCTTGGGAAGATAAATGTTAATGTTCCCAATAGTCAAGCTTGTTTTGCAGTAGTG
AAAAGCTTAGATGAGTACGGATACCTCATTTGAAACTCAGCCTAGTAAGGAAGTGAAAACTTAGCAGTCAGTGACATGGGGAAATAGTTA
TAGAAAATGTCACTGAATTTTTTCATATTTATAATTAGTCATTTACATATTTTTGTCTTGTTGATCATTACCTGTAAATGAAAGACCTTA
ATAGGAAAAAAAGAGTAAAGCTCAGTGTGAATGCAAACATCCACAAAATATGATCTTCGTTTATATTCTGTGATGTTGTTTATAAATGAA
TGCCTCAGTTCTCTGCTACCCTTTTCACAGCTTTGTACTGTTTGCCTTATATTCTATTTGTGCTTTTAAAGTGTGTCTGTTGGGAAAACA
AAATGTGTAGGTGGTTTGTAAGTGAATAATTTTTATTTCTTCTTGTATTAAAATTTTGTTTTTTTCTCTACTTTGGGAGATGTTTATTTA
CATTGTCAGACTATTCACAAAACAGATTCTAAAATTTGTTTGCTCGTATGCTGTTCCCTTCAATGTGATATCAGAGATTACTATGAATGT
TAGTTTCATTCCGTGAAACATTACTTCCATATAAAGACAGATCTCTTAATAAGTGAATCTAGTGGAAGAACATAGGTATCATTCTAATTC
CATGGTAAATTTTGTCATGATTCTATATGAATAATGGGGTCCTTCAGGAAGTTGGAATTTTTGCCTTCTCTTTTAATTGCAGTGAAGTTC
TCTTTATAACTTCTAAAATTCGGAATTCTAGATCCTTGCTTTTGCAGAATTTGGTGCTCAGACAATATTTAAGGACATTTCAGCGAGACA
AAGTGCATGTTTTTATCGAGTACCCTGTGCACCACATTATATCTGGCAATTCTTTTTGTTTCATTATGTGCATCAATATTTTTCTCAGCT
ACTATTACCTGAAACTTGTTTAACATGTATTAGACCTAGAATTTTCATTTTCTTTCTCACATAGTTGCTTCCTGGTATCTGATTTAGAAA
TAACATTTAAATGCCAAGTATCTGGGGGATTGAAGGAAGGGTCTATATGAGCAGGTGAATTAGCAGTACTGTTTTTGTTTAGTGGATATT
GTTAGTGACTTTTTGTGTGTGTTTTGCTTTGGGACCTTTTTATTTTGGTGTTGCAAAAAGTAACATATTTTCATCATTGCTTCATACGAC
ATGGAGTTAGGACAGGGAAAAATCATTCAACACTCCTTATGCATTAAATGATCAAATAAACCAGTGTAGGATATTAAGACTATCAATTGG
TGGGATTAGGCTTGACATTTTATTTTTATAAATATATATTTTTTCTGAATGTGTCTGAGTCCAAGAGTGGGCAAAAAATAATTTTCTACT
TTGGACTAATCTATAGAGGTTTTTGAAAGTCTGCATTACTAACTTGTTGAATTCATGATATTCTGCCTATGGCACAAATTGTAAACCTTT

>31020_31020_5_FOPNL-TMX3_FOPNL_chr16_15967348_ENST00000573429_TMX3_chr18_66369027_ENST00000299608_length(amino acids)=539AA_BP=73
MATVAELKAVLKDTLEKKGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREYLEFNKYKYTASVLIAAHCILRLLGSSSSPA
SASRVPGTTESGQPVVPLDRQFLIHELNAFEESKDNTIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMGIASEFG
VRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASE
EVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVAR
DYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKS

--------------------------------------------------------------
>31020_31020_6_FOPNL-TMX3_FOPNL_chr16_15967348_ENST00000575744_TMX3_chr18_66369027_ENST00000299608_length(transcript)=4613nt_BP=268nt
CCTGGCGGCCGTTGAAAAATGGCGACTGTGGCAGAGTTGAAGGCTGAATCTGGTCAACCTGTAGTTCCGTTGGACAGACAGTTTCTCATC
CATGAACTAAATGCATTTGAAGAATCAAAGGATAATACAATACCTCTTTTATATGGGATTTTAGCCCATTTCTTGCGTGGAACTAAGGAT
GGCATCCAGAATGCATTTCTGAAAGGGCCTTCACTTCAGCCTTCAGACCCAAGTCTTGGCAGACAACCTAGTAGAAGAAAGCCAATGGGC
ATTGCTTCAGAGTTTGGAGTTCGAGGTTATCCAACAATTAAGCTATTAAAAGGGGACTTGGCATATAATTATAGAGGACCACGAACAAAA
GATGATATTATTGAGTTTGCTCACAGAGTATCTGGGGCTCTAATTCGGCCACTTCCAAGTCAACAAATGTTTGAACATATGCAGAAGAGA
CACCGTGTATTTTTCGTTTATGTAGGTGGAGAATCACCTTTGAAAGAGAAATACATAGATGCTGCTTCAGAATTGATTGTATATACATAC
TTCTTTTCTGCCTCAGAAGAAGTGGTTCCTGAGTATGTGACACTAAAAGAGATGCCAGCTGTGCTTGTTTTCAAAGATGAAACTTACTTT
GTTTATGATGAGTATGAAGATGGTGATCTGTCATCATGGATCAACAGGGAAAGGTTTCAGAATTACCTTGCTATGGATGGCTTCCTCTTG
TATGAACTTGGAGACACAGGAAAGCTTGTGGCTCTTGCAGTTATTGATGAGAAAAATACATCAGTTGAACATACCAGATTGAAGTCAATT
ATTCAGGAAGTTGCAAGAGATTACAGAGACCTCTTCCATAGGGATTTTCAGTTTGGCCACATGGATGGAAATGACTACATAAATACCTTG
CTGATGGATGAATTGACAGTCCCAACTGTAGTTGTACTGAATACTTCAAACCAGCAATATTTCTTGCTAGATAGACAGATTAAGAATGTT
GAAGACATGGTCCAGTTTATTAATAACATTTTGGATGGCACAGTAGAAGCCCAAGGAGGTGATAGCATTTTGCAGAGATTGAAAAGAATA
GTATTTGATGCCAAATCTACTATTGTGTCTATATTCAAGAGCTCACCACTGATGGGCTGCTTTCTCTTTGGCCTGCCACTGGGTGTCATC
AGTATCATGTGCTATGGAATCTACACAGCCGACACAGATGGAGGTTATATAGAAGAACGATATGAAGTGTCTAAAAGTGAAAATGAAAAC
CAAGAACAGATAGAAGAGAGCAAAGAACAGCAGGAGCCCAGCAGTGGAGGATCTGTAGTGCCTACAGTGCAGGAGCCCAAGGATGTATTA
GAAAAGAAGAAAGATTGAGACTTGATGACTATAAAATATTTGTTAGGACTTCAAATTATTAAAGAGTCTATTTATTGAATTTAGACATTT
AATCATGATCTTTACAGAAAAGAACATGTTATTCGTATTTTGCTAATATCAACTGCATGGATTAAAGTAGTCCCTCCATACATGGGGAAG
TGTTTGGAGCAAAGAGATGAACAGTTTGTCTGAAACAAACACAGAGCACTCCATCAAAATTTACCTGATCTTTGTGATTAGAACAGAACA
ATTCTATTTGCATGTTTCTCTATCTGAATATTCTGTGACAAAAAGTTAAGATTCTTGGGCAGAATATTTAAATTGGTCAGTCAGGTAGAA
GATACATGTGTGATATAGAAAAATAATGCCTCTCCTGCTGCCATCCGTTTCCCTCATATATTTTGGACAAGATTTATATGGACAAAATTA
AGTCTTTAAAATTTAGGCACTTTAAGGAGAACTAATAACTTTTTCCATGTATCAAGATTATGAGGTTAAAAATAATGTGGTTTTATATAG
CATAGTGGTTTTATTTTGTTAGTTATTTTTAAAGGAGAAGAAATGTTACTTTTTAACTTTATACTCAGTTGCATTATCATAAAATTTTCA
TATATGCCTAGATAATGGGGAAAAAAAGTCTTGTGATTGACTTTCGCAAAATAAACAGGATTTACTGAGTAGAGGTTTCAGCCCATTCCT
TGGAATACTAACAGGTATTTCATCAGTCATTGTAGGTTGGGAAGGGTCTCTGTTAATCCTACTCTGCTTTAGCCAGAATAGCCTAGTATT
TTATTTCTATTTTATATATTGAGATTTCTTCTAACATTTCCTTTGATAAAAATCTTCTGCTTTTTGAAAAGTGGTATGTATCATATTTTT
ATGTTTCTGGTGTGTGAACTTTATGGTAACTTCTACTCTAGAATACGTACGTATGCACCCACAGACACACACAGTTTATTGACACATCTA
TTATGTAATGCTGTAGACCTGTCCGTGTCTGCTTCATAAGGAGTAACGACTGACATTAGCATGTCCAGTGACAAGTCACATCCGGTGTAA
AAAAAAGAGATCAGCCAGTTACCTTCTCCATTGTCTTAGTTCTGTCACCCATTTCGTCAAGTGACCTCTCATCTTCTATAAACTAATACA
GGAATTCTTTCCAAAGCAATGTCTAAAAACTCTTTTTTTTAAAGTAACAGTTTGGTATGTTTATTGTAGATAAATTATTTTTGAGGCCTT
CATTTTAGCTAAGTTTAGAATTTATATTAGGCAACTATGATTTGAGTGGTTATTCATTGAGTAATTTTCCACTATAAAGAATTTTATTGA
ACATTTATTAAAAAATAATGTAATGCATGGTCAAAAAATATGTAATTCATGGTCTGGACACTGACGTTGTTTAGGGATTTAGTCATCAAG
GACAGCCCTCTGTTGTTTCTAATGCCGTACTAATCAAGACTGTATGGACACTTGCATCTTAAGTACTAAGGAATTACTAGTGATTGTTTT
ATTTTATCCATGTACTCTTTTAGTATTTAATAATTAAATACCTATTCTTAGTGTTTGACACTCCATATTTCTTTTTTTTGGAAATGAAAC
AAATATGCAGTCCAAAATTCAGGAACTACTAGAGTGAAATGATATTAAGTGGAAACCAGAGATAAATGCTGTTAATTTAACAAGTAGATT
CTTCTCCAAAGAATGATGAGTGATTCTTGGGAAGATAAATGTTAATGTTCCCAATAGTCAAGCTTGTTTTGCAGTAGTGAAAAGCTTAGA
TGAGTACGGATACCTCATTTGAAACTCAGCCTAGTAAGGAAGTGAAAACTTAGCAGTCAGTGACATGGGGAAATAGTTATAGAAAATGTC
ACTGAATTTTTTCATATTTATAATTAGTCATTTACATATTTTTGTCTTGTTGATCATTACCTGTAAATGAAAGACCTTAATAGGAAAAAA
AGAGTAAAGCTCAGTGTGAATGCAAACATCCACAAAATATGATCTTCGTTTATATTCTGTGATGTTGTTTATAAATGAATGCCTCAGTTC
TCTGCTACCCTTTTCACAGCTTTGTACTGTTTGCCTTATATTCTATTTGTGCTTTTAAAGTGTGTCTGTTGGGAAAACAAAATGTGTAGG
TGGTTTGTAAGTGAATAATTTTTATTTCTTCTTGTATTAAAATTTTGTTTTTTTCTCTACTTTGGGAGATGTTTATTTACATTGTCAGAC
TATTCACAAAACAGATTCTAAAATTTGTTTGCTCGTATGCTGTTCCCTTCAATGTGATATCAGAGATTACTATGAATGTTAGTTTCATTC
CGTGAAACATTACTTCCATATAAAGACAGATCTCTTAATAAGTGAATCTAGTGGAAGAACATAGGTATCATTCTAATTCCATGGTAAATT
TTGTCATGATTCTATATGAATAATGGGGTCCTTCAGGAAGTTGGAATTTTTGCCTTCTCTTTTAATTGCAGTGAAGTTCTCTTTATAACT
TCTAAAATTCGGAATTCTAGATCCTTGCTTTTGCAGAATTTGGTGCTCAGACAATATTTAAGGACATTTCAGCGAGACAAAGTGCATGTT
TTTATCGAGTACCCTGTGCACCACATTATATCTGGCAATTCTTTTTGTTTCATTATGTGCATCAATATTTTTCTCAGCTACTATTACCTG
AAACTTGTTTAACATGTATTAGACCTAGAATTTTCATTTTCTTTCTCACATAGTTGCTTCCTGGTATCTGATTTAGAAATAACATTTAAA
TGCCAAGTATCTGGGGGATTGAAGGAAGGGTCTATATGAGCAGGTGAATTAGCAGTACTGTTTTTGTTTAGTGGATATTGTTAGTGACTT
TTTGTGTGTGTTTTGCTTTGGGACCTTTTTATTTTGGTGTTGCAAAAAGTAACATATTTTCATCATTGCTTCATACGACATGGAGTTAGG
ACAGGGAAAAATCATTCAACACTCCTTATGCATTAAATGATCAAATAAACCAGTGTAGGATATTAAGACTATCAATTGGTGGGATTAGGC
TTGACATTTTATTTTTATAAATATATATTTTTTCTGAATGTGTCTGAGTCCAAGAGTGGGCAAAAAATAATTTTCTACTTTGGACTAATC
TATAGAGGTTTTTGAAAGTCTGCATTACTAACTTGTTGAATTCATGATATTCTGCCTATGGCACAAATTGTAAACCTTTGTTTTTCTAAA

>31020_31020_6_FOPNL-TMX3_FOPNL_chr16_15967348_ENST00000575744_TMX3_chr18_66369027_ENST00000299608_length(amino acids)=449AA_BP=83
MATVAELKAESGQPVVPLDRQFLIHELNAFEESKDNTIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMGIASEFG
VRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASE
EVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVAR
DYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FOPNL-TMX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOPNL-TMX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOPNL-TMX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource