Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FOSB-FN1 (FusionGDB2 ID:31022)

Fusion Gene Summary for FOSB-FN1

Fusion gene summary

Fusion gene information	Fusion gene name: FOSB-FN1
	Fusion gene ID: 31022
		Hgene	Tgene
	Gene symbol	FOSB	FN1
	Gene ID	2354	2335
	Gene name	FosB proto-oncogene, AP-1 transcription factor subunit	fibronectin 1
	Synonyms	AP-1\|G0S3\|GOS3\|GOSB	CIG\|ED-B\|FINC\|FN\|FNZ\|GFND\|GFND2\|LETS\|MSF\|SMDCF
	Cytomap	19q13.32	2q35
	Type of gene	protein-coding	protein-coding
	Description	protein fosBFBJ murine osteosarcoma viral oncogene homolog BFosB proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 3activator protein 1	fibronectincold-insoluble globulinepididymis secretory sperm binding proteinmigration-stimulating factor
	Modification date	20200313	20200329
	UniProtAcc	P53539	P02751
	Ensembl transtripts involved in fusion gene	ENST00000353609, ENST00000417353, ENST00000443841, ENST00000585836, ENST00000586615, ENST00000591858, ENST00000592436, ENST00000592811, ENST00000590335,	ENST00000323926, ENST00000336916, ENST00000345488, ENST00000346544, ENST00000354785, ENST00000356005, ENST00000357009, ENST00000357867, ENST00000359671, ENST00000421182, ENST00000426059, ENST00000432072, ENST00000443816, ENST00000446046, ENST00000490833,
Fusion gene scores	* DoF score	3 X 3 X 2=18	35 X 39 X 9=12285
	# samples	3	42
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(42/12285*10)=-4.8703647195834 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FOSB [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FOSB(45975895)-FN1(216273026), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FN1	GO:0001932	regulation of protein phosphorylation	11792823
Tgene	FN1	GO:0008284	positive regulation of cell proliferation	25834989
Tgene	FN1	GO:0010628	positive regulation of gene expression	25834989
Tgene	FN1	GO:0018149	peptide cross-linking	3997886
Tgene	FN1	GO:0034446	substrate adhesion-dependent cell spreading	16236823
Tgene	FN1	GO:0035987	endodermal cell differentiation	23154389
Tgene	FN1	GO:0048146	positive regulation of fibroblast proliferation	25834989
Tgene	FN1	GO:0051702	interaction with symbiont	12167537\|12421310\|19429745
Tgene	FN1	GO:0070372	regulation of ERK1 and ERK2 cascade	11792823
Tgene	FN1	GO:1901166	neural crest cell migration involved in autonomic nervous system development	26571399
Tgene	FN1	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	25834989
Tgene	FN1	GO:2001202	negative regulation of transforming growth factor-beta secretion	25834989

Fusion gene breakpoints across FOSB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF809968	FOSB	chr19	45975895	+	FN1	chr2	216273026	+

Top

Fusion Gene ORF analysis for FOSB-FN1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000353609	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000353609	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000417353	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000443841	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000585836	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000586615	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000591858	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592436	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
5CDS-intron	ENST00000592811	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000323926	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000336916	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000345488	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000346544	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000354785	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000356005	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000357009	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000357867	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000359671	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000421182	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000426059	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000432072	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000443816	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000446046	FOSB	chr19	45975895	+	FN1	chr2	216273026	+
intron-intron	ENST00000590335	ENST00000490833	FOSB	chr19	45975895	+	FN1	chr2	216273026	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for FOSB-FN1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FOSB-FN1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45975895/:216273026)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FOSB P53539	FN1 P02751
FUNCTION: FosB interacts with Jun proteins enhancing their DNA binding activity.	FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250\|UniProtKB:P11276, ECO:0000269\|PubMed:3024962, ECO:0000269\|PubMed:34089617, ECO:0000269\|PubMed:3593230, ECO:0000269\|PubMed:3900070, ECO:0000269\|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269\|PubMed:11209058, ECO:0000269\|PubMed:15665290, ECO:0000269\|PubMed:19379667, ECO:0000269\|PubMed:8114919}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for FOSB-FN1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for FOSB-FN1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FOSB-FN1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FOSB-FN1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source