|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FOSB-ITPKC (FusionGDB2 ID:31023) |
Fusion Gene Summary for FOSB-ITPKC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOSB-ITPKC | Fusion gene ID: 31023 | Hgene | Tgene | Gene symbol | FOSB | ITPKC | Gene ID | 2354 | 80271 |
| Gene name | FosB proto-oncogene, AP-1 transcription factor subunit | inositol-trisphosphate 3-kinase C | |
| Synonyms | AP-1|G0S3|GOS3|GOSB | IP3-3KC|IP3KC | |
| Cytomap | 19q13.32 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein fosBFBJ murine osteosarcoma viral oncogene homolog BFosB proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 3activator protein 1 | inositol-trisphosphate 3-kinase CIP3 3-kinase CIP3K CInsP 3 kinase Cinositol 1,4,5-trisphosphate 3-kinase CinsP 3-kinase C | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P53539 | Q96DU7 | |
| Ensembl transtripts involved in fusion gene | ENST00000590335, ENST00000353609, ENST00000417353, ENST00000585836, ENST00000586615, ENST00000591858, ENST00000592436, ENST00000592811, ENST00000443841, | ENST00000263370, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 6 X 5 X 4=120 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FOSB [Title/Abstract] AND ITPKC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FOSB(45974207)-ITPKC(41231245), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FOSB-ITPKC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FOSB-ITPKC seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. FOSB-ITPKC seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FOSB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across ITPKC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | CESC | TCGA-C5-A7X3-01A | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
Top |
Fusion Gene ORF analysis for FOSB-ITPKC |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000590335 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| In-frame | ENST00000353609 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| In-frame | ENST00000417353 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| In-frame | ENST00000585836 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| In-frame | ENST00000586615 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| In-frame | ENST00000591858 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| In-frame | ENST00000592436 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| In-frame | ENST00000592811 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| intron-3CDS | ENST00000443841 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000353609 | FOSB | chr19 | 45974207 | - | ENST00000263370 | ITPKC | chr19 | 41231245 | + | 3236 | 1039 | 250 | 1935 | 561 |
| ENST00000585836 | FOSB | chr19 | 45974207 | - | ENST00000263370 | ITPKC | chr19 | 41231245 | + | 3119 | 922 | 250 | 1818 | 522 |
| ENST00000591858 | FOSB | chr19 | 45974207 | - | ENST00000263370 | ITPKC | chr19 | 41231245 | + | 3119 | 922 | 250 | 1818 | 522 |
| ENST00000417353 | FOSB | chr19 | 45974207 | - | ENST00000263370 | ITPKC | chr19 | 41231245 | + | 3236 | 1039 | 250 | 1935 | 561 |
| ENST00000592436 | FOSB | chr19 | 45974207 | - | ENST00000263370 | ITPKC | chr19 | 41231245 | + | 2796 | 599 | 98 | 1495 | 465 |
| ENST00000592811 | FOSB | chr19 | 45974207 | - | ENST00000263370 | ITPKC | chr19 | 41231245 | + | 3271 | 1074 | 774 | 1970 | 398 |
| ENST00000586615 | FOSB | chr19 | 45974207 | - | ENST00000263370 | ITPKC | chr19 | 41231245 | + | 3234 | 1037 | 737 | 1933 | 398 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000353609 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + | 0.018384837 | 0.9816151 |
| ENST00000585836 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + | 0.028750464 | 0.97124946 |
| ENST00000591858 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + | 0.028750464 | 0.97124946 |
| ENST00000417353 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + | 0.018384837 | 0.9816151 |
| ENST00000592436 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + | 0.02408793 | 0.97591203 |
| ENST00000592811 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + | 0.011043076 | 0.988957 |
| ENST00000586615 | ENST00000263370 | FOSB | chr19 | 45974207 | - | ITPKC | chr19 | 41231245 | + | 0.010939742 | 0.9890603 |
Top |
Fusion Genomic Features for FOSB-ITPKC |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for FOSB-ITPKC |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45974207/chr19:41231245) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOSB | ITPKC |
| FUNCTION: FosB interacts with Jun proteins enhancing their DNA binding activity. | FUNCTION: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ITPKC | chr19:45974207 | chr19:41231245 | ENST00000263370 | 0 | 7 | 471_473 | 385 | 684.0 | Nucleotide binding | ATP | |
| Tgene | ITPKC | chr19:45974207 | chr19:41231245 | ENST00000263370 | 0 | 7 | 507_513 | 385 | 684.0 | Region | Note=Substrate binding | |
| Tgene | ITPKC | chr19:45974207 | chr19:41231245 | ENST00000263370 | 0 | 7 | 509_517 | 385 | 684.0 | Region | Calmodulin-binding | |
| Tgene | ITPKC | chr19:45974207 | chr19:41231245 | ENST00000263370 | 0 | 7 | 534_541 | 385 | 684.0 | Region | Note=Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FOSB | chr19:45974207 | chr19:41231245 | ENST00000353609 | - | 2 | 4 | 155_218 | 149 | 339.0 | Domain | bZIP |
| Hgene | FOSB | chr19:45974207 | chr19:41231245 | ENST00000417353 | - | 2 | 3 | 155_218 | 149 | 303.0 | Domain | bZIP |
| Hgene | FOSB | chr19:45974207 | chr19:41231245 | ENST00000353609 | - | 2 | 4 | 157_182 | 149 | 339.0 | Region | Basic motif |
| Hgene | FOSB | chr19:45974207 | chr19:41231245 | ENST00000353609 | - | 2 | 4 | 183_211 | 149 | 339.0 | Region | Leucine-zipper |
| Hgene | FOSB | chr19:45974207 | chr19:41231245 | ENST00000417353 | - | 2 | 3 | 157_182 | 149 | 303.0 | Region | Basic motif |
| Hgene | FOSB | chr19:45974207 | chr19:41231245 | ENST00000417353 | - | 2 | 3 | 183_211 | 149 | 303.0 | Region | Leucine-zipper |
| Tgene | ITPKC | chr19:45974207 | chr19:41231245 | ENST00000263370 | 0 | 7 | 324_332 | 385 | 684.0 | Motif | Nuclear export signal |
Top |
Fusion Gene Sequence for FOSB-ITPKC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >31023_31023_1_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000353609_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=3236nt_BP=1039nt CATTCATAAGACTCAGAGCTACGGCCACGGCAGGGACACGCGGAACCAAGACTTGGAAACTTGATTGTTGTGGTTCTTCTTGGGGGTTAT GAAATTTCATTAATCTTTTTTTTTCCGGGGAGAAAGTTTTTGGAAAGATTCTTCCAGATATTTCTTCATTTTCTTTTGGAGGACCGACTT ACTTTTTTTGGTCTTCTTTATTACTCCCCTCCCCCCGTGGGACCCGCCGGACGCGTGGAGGAGACCGTAGCTGAAGCTGATTCTGTACAG CGGGACAGCGCTTTCTGCCCCTGGGGGAGCAACCCCTCCCTCGCCCCTGGGTCCTACGGAGCCTGCACTTTCAAGAGGTACAGCGGCATC CTGTGGGGGCCTGGGCACCGCAGGAAGACTGCACAGAAACTTTGCCATTGTTGGAACGGGACGTTGCTCCTTCCCCGAGCTTCCCCGGAC AGCGTACTTTGAGGACTCGCTCAGCTCACCGGGGACTCCCACGGCTCACCCCGGACTTGCACCTTACTTCCCCAACCCGGCCATAGCCTT GGCTTCCCGGCGACCTCAGCGTGGTCACAGGGGCCCCCCTGTGCCCAGGGAAATGTTTCAGGCTTTCCCCGGAGACTACGACTCCGGCTC CCGGTGCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCCAGGA GTGCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATCACAACCAGCCAGGACCTCCAGTGGCTTGTGCAACC CACCCTCATCTCTTCCATGGCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAG CTACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGG GCCTGCCCGCCCAGCCCGAGCCCGGCCTAGGAGACCCCGAGAGGAGACGAGCAAACCCTGGAAGAAGCTGAAGACAGTTCTGAAGTATTC ACCCTTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAGGCAGGAGAGGATGGTCGGAT TCTGAAACGTTTCTGTCAGTGTGAGCAGCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCTACTATGGCAT GGTGCTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATTATGGACTGCAAGATGGGCAG CAGGACCTATCTGGAAGAGGAGCTAGTGAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGGCTGTGGACCC TGGGGCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAAACCATGAGCTCCACCTCTAC CCTGGGCTTCCGGATCGAGGGCATCAAGAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGCAGGTGACAAA AGTGCTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTTCGTGAAGCTCTGGAGATCTC CCCCTTCTTCAAGACCCACGAGGTGGTAGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGATGATAGACTT CGGCAAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGTGAGGACGGCTACCTCTGGGG CCTGGACAACATGATCTGCCTCCTGCAGGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAATTGGATGGCGCCAGTCTGGC TGGAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTCATGTGCCACA CGAGACCAACGTGGAAAAGTCTGAAGGGCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGGACCTGGAAGG AAGGTGATGAGGCAGTGAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGAGAGCATTCAG TTCACATGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCCAGGCTGCCAG CTGGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAGGCGCTGCTGGACCA TCTGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAGGGCATGACCCCATGGGACTG GATGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGTTCCTCGGCGGACTCTGCTGA CCTCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTCTGTGCACCAGATCCGGCCTC AGGACTTACACCTCCTGCCTGACCCCCAGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAGAGGCTGGGAA AGTGGGCCTCCCCTTGCAACTCAGAGCTGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGCTGGGTGTGTG TCAGAGGCGCAGGGTGGGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTGGGGTGTGGCT AACGGCCCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTAAGCTGAAGCT CCCACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGCAGTTGCTGGACGGG >31023_31023_1_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000353609_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=561AA_BP=251 MKLILYSGTALSAPGGATPPSPLGPTEPALSRGTAASCGGLGTAGRLHRNFAIVGTGRCSFPELPRTAYFEDSLSSPGTPTAHPGLAPYF PNPAIALASRRPQRGHRGPPVPREMFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQD LQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETSKPWKKL KTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSI MDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQ ALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNR -------------------------------------------------------------- >31023_31023_2_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000417353_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=3236nt_BP=1039nt CATTCATAAGACTCAGAGCTACGGCCACGGCAGGGACACGCGGAACCAAGACTTGGAAACTTGATTGTTGTGGTTCTTCTTGGGGGTTAT GAAATTTCATTAATCTTTTTTTTTCCGGGGAGAAAGTTTTTGGAAAGATTCTTCCAGATATTTCTTCATTTTCTTTTGGAGGACCGACTT ACTTTTTTTGGTCTTCTTTATTACTCCCCTCCCCCCGTGGGACCCGCCGGACGCGTGGAGGAGACCGTAGCTGAAGCTGATTCTGTACAG CGGGACAGCGCTTTCTGCCCCTGGGGGAGCAACCCCTCCCTCGCCCCTGGGTCCTACGGAGCCTGCACTTTCAAGAGGTACAGCGGCATC CTGTGGGGGCCTGGGCACCGCAGGAAGACTGCACAGAAACTTTGCCATTGTTGGAACGGGACGTTGCTCCTTCCCCGAGCTTCCCCGGAC AGCGTACTTTGAGGACTCGCTCAGCTCACCGGGGACTCCCACGGCTCACCCCGGACTTGCACCTTACTTCCCCAACCCGGCCATAGCCTT GGCTTCCCGGCGACCTCAGCGTGGTCACAGGGGCCCCCCTGTGCCCAGGGAAATGTTTCAGGCTTTCCCCGGAGACTACGACTCCGGCTC CCGGTGCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCCAGGA GTGCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATCACAACCAGCCAGGACCTCCAGTGGCTTGTGCAACC CACCCTCATCTCTTCCATGGCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAG CTACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGG GCCTGCCCGCCCAGCCCGAGCCCGGCCTAGGAGACCCCGAGAGGAGACGAGCAAACCCTGGAAGAAGCTGAAGACAGTTCTGAAGTATTC ACCCTTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAGGCAGGAGAGGATGGTCGGAT TCTGAAACGTTTCTGTCAGTGTGAGCAGCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCTACTATGGCAT GGTGCTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATTATGGACTGCAAGATGGGCAG CAGGACCTATCTGGAAGAGGAGCTAGTGAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGGCTGTGGACCC TGGGGCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAAACCATGAGCTCCACCTCTAC CCTGGGCTTCCGGATCGAGGGCATCAAGAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGCAGGTGACAAA AGTGCTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTTCGTGAAGCTCTGGAGATCTC CCCCTTCTTCAAGACCCACGAGGTGGTAGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGATGATAGACTT CGGCAAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGTGAGGACGGCTACCTCTGGGG CCTGGACAACATGATCTGCCTCCTGCAGGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAATTGGATGGCGCCAGTCTGGC TGGAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTCATGTGCCACA CGAGACCAACGTGGAAAAGTCTGAAGGGCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGGACCTGGAAGG AAGGTGATGAGGCAGTGAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGAGAGCATTCAG TTCACATGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCCAGGCTGCCAG CTGGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAGGCGCTGCTGGACCA TCTGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAGGGCATGACCCCATGGGACTG GATGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGTTCCTCGGCGGACTCTGCTGA CCTCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTCTGTGCACCAGATCCGGCCTC AGGACTTACACCTCCTGCCTGACCCCCAGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAGAGGCTGGGAA AGTGGGCCTCCCCTTGCAACTCAGAGCTGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGCTGGGTGTGTG TCAGAGGCGCAGGGTGGGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTGGGGTGTGGCT AACGGCCCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTAAGCTGAAGCT CCCACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGCAGTTGCTGGACGGG >31023_31023_2_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000417353_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=561AA_BP=251 MKLILYSGTALSAPGGATPPSPLGPTEPALSRGTAASCGGLGTAGRLHRNFAIVGTGRCSFPELPRTAYFEDSLSSPGTPTAHPGLAPYF PNPAIALASRRPQRGHRGPPVPREMFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQD LQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETSKPWKKL KTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSI MDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQ ALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNR -------------------------------------------------------------- >31023_31023_3_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000585836_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=3119nt_BP=922nt CATTCATAAGACTCAGAGCTACGGCCACGGCAGGGACACGCGGAACCAAGACTTGGAAACTTGATTGTTGTGGTTCTTCTTGGGGGTTAT GAAATTTCATTAATCTTTTTTTTTCCGGGGAGAAAGTTTTTGGAAAGATTCTTCCAGATATTTCTTCATTTTCTTTTGGAGGACCGACTT ACTTTTTTTGGTCTTCTTTATTACTCCCCTCCCCCCGTGGGACCCGCCGGACGCGTGGAGGAGACCGTAGCTGAAGCTGATTCTGTACAG CGGGACAGCGCTTTCTGCCCCTGGGGGAGCAACCCCTCCCTCGCCCCTGGGTCCTACGGAGCCTGCACTTTCAAGAGGTACAGCGGCATC CTGTGGGGGCCTGGGCACCGCAGGAAGACTGCACAGAAACTTTGCCATTGTTGGAACGGGACGTTGCTCCTTCCCCGAGCTTCCCCGGAC AGCGTACTTTGAGGACTCGCTCAGCTCACCGGGGACTCCCACGGCTCACCCCGGACTTGCACCTTACTTCCCCAACCCGGCCATAGCCTT GGCTTCCCGGCGACCTCAGCGTGGTCACAGGGGCCCCCCTGTGCCCAGGGAAATGTTTCAGGCTTTCCCCGGAGACTACGACTCCGGCTC CCGGTGCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCCAGTC CCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAGCTACTCCACACCAGGCATGAGTGGCTA CAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGGGCCTGCCCGCCCAGCCCGAGCCCGGCC TAGGAGACCCCGAGAGGAGACGAGCAAACCCTGGAAGAAGCTGAAGACAGTTCTGAAGTATTCACCCTTTGTGGTCTCCTTCCGAAAACA CTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAGGCAGGAGAGGATGGTCGGATTCTGAAACGTTTCTGTCAGTGTGAGCA GCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCTACTATGGCATGGTGCTGCAGGATGGCCAGACCTTCAA CCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATTATGGACTGCAAGATGGGCAGCAGGACCTATCTGGAAGAGGAGCTAGT GAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGGCTGTGGACCCTGGGGCCCCTACCCCTGAGGAGCATGC CCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAAACCATGAGCTCCACCTCTACCCTGGGCTTCCGGATCGAGGGCATCAA GAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGCAGGTGACAAAAGTGCTGGAGGACTTCGTGGATGGAGA CCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTTCGTGAAGCTCTGGAGATCTCCCCCTTCTTCAAGACCCACGAGGTGGT AGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGATGATAGACTTCGGCAAGACGGTGGCCTTGCCCGACCA CCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGTGAGGACGGCTACCTCTGGGGCCTGGACAACATGATCTGCCTCCTGCA GGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAATTGGATGGCGCCAGTCTGGCTGGAGGAGCCCTGAGATGCCATGGGAG GCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTCATGTGCCACACGAGACCAACGTGGAAAAGTCTGAAGG GCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGGACCTGGAAGGAAGGTGATGAGGCAGTGAGTCAGAAAA ACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGAGAGCATTCAGTTCACATGTCACAGGGTATGGTGTGAC AGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCCAGGCTGCCAGCTGGCTGAGGCCAGGGACTGGGTCAGG CTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAGGCGCTGCTGGACCATCTGGGGAGAGTGACAGTCCATGTCTT CACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAGGGCATGACCCCATGGGACTGGATGCGGCCTGAGGGCTGATACCGCTG GGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGTTCCTCGGCGGACTCTGCTGACCTCCTGCAGACCCAAACCACAGCCAC ATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTCTGTGCACCAGATCCGGCCTCAGGACTTACACCTCCTGCCTGACCCCC AGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAGAGGCTGGGAAAGTGGGCCTCCCCTTGCAACTCAGAGC TGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGCTGGGTGTGTGTCAGAGGCGCAGGGTGGGTGGGGCTGC CAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTGGGGTGTGGCTAACGGCCCCTCCAGCACCCATAGCCAG GTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTAAGCTGAAGCTCCCACACTGTCTTCCAGGGCTGAGGAG ATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGCAGTTGCTGGACGGGGTAGTACTGGGAAGCAGGAGGCAGAAT >31023_31023_3_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000585836_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=522AA_BP=212 MKLILYSGTALSAPGGATPPSPLGPTEPALSRGTAASCGGLGTAGRLHRNFAIVGTGRCSFPELPRTAYFEDSLSSPGTPTAHPGLAPYF PNPAIALASRRPQRGHRGPPVPREMFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQSQGQPLASQPPVVDPYDMPGTSYS TPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILK RFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGA PTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPF -------------------------------------------------------------- >31023_31023_4_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000586615_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=3234nt_BP=1037nt CATTTACGGGAGGGGGGAGATGAGCGCTGCTGAGGCTTGGGGGCTCAGGTCCCGCACCATTCCCCCTCCGCGACAATCTGAGAGAGCTCC AGTGGTTACTTTTATCTACCTGTCCGTTCACCCTAAACTGTCACTCGTCAGTCTCACTCTGAGAAGAGACAGTAACTTGAAACGTTGTTC TAAACTCCTAGGCCCGTCCCCCAAACACCCTTTTGACTGGGACCCCCGCCCCTGCATGGGACCTCGCGCAGAGGGGGGTGTGTATGTGTG TGAGTGTAGAGGAAGGCTTGGCCTAAGGCCTCTCCTTCTCCCTCCCCTTGCCTCTGGGGTGGGGGTGGGGTGTTGTGGCTGTGTGTGTGG CTGTGGCTCCGTCCCGGGGGTTCTGTCACCCGGCTGTGTCCAGCCTCCTCTCCACCCCCCATACCTAAGAGTCACCAACCCGGGGTGTGA TTCACCACCCGCTGGAACCGTGCAACCTTTCCCCGAGGAAGAAGGAGGAGGTAGAAGCCAGTTGAGCAGAAATCCTCTCATTAACCACTG CGTCACGGTGTAGTGGAAGGGTGGGTGTTGTGGCTTTTTCCCTGTGACACACACATCCACACTCGCTCACCCTGTGCTCACTCACGGGGT CGGTGTGTGTTATGTGTGTTGGGTGTGTGTGTGTCGGTGTCTTTGTTTGTGTGTCTACGCCTGTGTGTGTATGTGTCACCCCGTAGGAGT GCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATCACAACCAGCCAGGACCTCCAGTGGCTTGTGCAACCCA CCCTCATCTCTTCCATGGCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAGCT ACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGGGC CTGCCCGCCCAGCCCGAGCCCGGCCTAGGAGACCCCGAGAGGAGACGAGCAAACCCTGGAAGAAGCTGAAGACAGTTCTGAAGTATTCAC CCTTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAGGCAGGAGAGGATGGTCGGATTC TGAAACGTTTCTGTCAGTGTGAGCAGCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCTACTATGGCATGG TGCTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATTATGGACTGCAAGATGGGCAGCA GGACCTATCTGGAAGAGGAGCTAGTGAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGGCTGTGGACCCTG GGGCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAAACCATGAGCTCCACCTCTACCC TGGGCTTCCGGATCGAGGGCATCAAGAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGCAGGTGACAAAAG TGCTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTTCGTGAAGCTCTGGAGATCTCCC CCTTCTTCAAGACCCACGAGGTGGTAGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGATGATAGACTTCG GCAAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGTGAGGACGGCTACCTCTGGGGCC TGGACAACATGATCTGCCTCCTGCAGGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAATTGGATGGCGCCAGTCTGGCTG GAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTCATGTGCCACACG AGACCAACGTGGAAAAGTCTGAAGGGCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGGACCTGGAAGGAA GGTGATGAGGCAGTGAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGAGAGCATTCAGTT CACATGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCCAGGCTGCCAGCT GGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAGGCGCTGCTGGACCATC TGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAGGGCATGACCCCATGGGACTGGA TGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGTTCCTCGGCGGACTCTGCTGACC TCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTCTGTGCACCAGATCCGGCCTCAG GACTTACACCTCCTGCCTGACCCCCAGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAGAGGCTGGGAAAG TGGGCCTCCCCTTGCAACTCAGAGCTGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGCTGGGTGTGTGTC AGAGGCGCAGGGTGGGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTGGGGTGTGGCTAA CGGCCCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTAAGCTGAAGCTCC CACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGCAGTTGCTGGACGGGGT >31023_31023_4_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000586615_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=398AA_BP=88 MPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPAR ARPRRPREETSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQ TFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIE GIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVAL -------------------------------------------------------------- >31023_31023_5_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000591858_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=3119nt_BP=922nt CATTCATAAGACTCAGAGCTACGGCCACGGCAGGGACACGCGGAACCAAGACTTGGAAACTTGATTGTTGTGGTTCTTCTTGGGGGTTAT GAAATTTCATTAATCTTTTTTTTTCCGGGGAGAAAGTTTTTGGAAAGATTCTTCCAGATATTTCTTCATTTTCTTTTGGAGGACCGACTT ACTTTTTTTGGTCTTCTTTATTACTCCCCTCCCCCCGTGGGACCCGCCGGACGCGTGGAGGAGACCGTAGCTGAAGCTGATTCTGTACAG CGGGACAGCGCTTTCTGCCCCTGGGGGAGCAACCCCTCCCTCGCCCCTGGGTCCTACGGAGCCTGCACTTTCAAGAGGTACAGCGGCATC CTGTGGGGGCCTGGGCACCGCAGGAAGACTGCACAGAAACTTTGCCATTGTTGGAACGGGACGTTGCTCCTTCCCCGAGCTTCCCCGGAC AGCGTACTTTGAGGACTCGCTCAGCTCACCGGGGACTCCCACGGCTCACCCCGGACTTGCACCTTACTTCCCCAACCCGGCCATAGCCTT GGCTTCCCGGCGACCTCAGCGTGGTCACAGGGGCCCCCCTGTGCCCAGGGAAATGTTTCAGGCTTTCCCCGGAGACTACGACTCCGGCTC CCGGTGCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCCAGTC CCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGCCGGGAACCAGCTACTCCACACCAGGCATGAGTGGCTA CAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGGGCCTGCCCGCCCAGCCCGAGCCCGGCC TAGGAGACCCCGAGAGGAGACGAGCAAACCCTGGAAGAAGCTGAAGACAGTTCTGAAGTATTCACCCTTTGTGGTCTCCTTCCGAAAACA CTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAGGCAGGAGAGGATGGTCGGATTCTGAAACGTTTCTGTCAGTGTGAGCA GCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCTACTATGGCATGGTGCTGCAGGATGGCCAGACCTTCAA CCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATTATGGACTGCAAGATGGGCAGCAGGACCTATCTGGAAGAGGAGCTAGT GAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGGCTGTGGACCCTGGGGCCCCTACCCCTGAGGAGCATGC CCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAAACCATGAGCTCCACCTCTACCCTGGGCTTCCGGATCGAGGGCATCAA GAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGCAGGTGACAAAAGTGCTGGAGGACTTCGTGGATGGAGA CCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTTCGTGAAGCTCTGGAGATCTCCCCCTTCTTCAAGACCCACGAGGTGGT AGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGATGATAGACTTCGGCAAGACGGTGGCCTTGCCCGACCA CCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGTGAGGACGGCTACCTCTGGGGCCTGGACAACATGATCTGCCTCCTGCA GGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAATTGGATGGCGCCAGTCTGGCTGGAGGAGCCCTGAGATGCCATGGGAG GCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTCATGTGCCACACGAGACCAACGTGGAAAAGTCTGAAGG GCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGGACCTGGAAGGAAGGTGATGAGGCAGTGAGTCAGAAAA ACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGAGAGCATTCAGTTCACATGTCACAGGGTATGGTGTGAC AGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCCAGGCTGCCAGCTGGCTGAGGCCAGGGACTGGGTCAGG CTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAGGCGCTGCTGGACCATCTGGGGAGAGTGACAGTCCATGTCTT CACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAGGGCATGACCCCATGGGACTGGATGCGGCCTGAGGGCTGATACCGCTG GGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGTTCCTCGGCGGACTCTGCTGACCTCCTGCAGACCCAAACCACAGCCAC ATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTCTGTGCACCAGATCCGGCCTCAGGACTTACACCTCCTGCCTGACCCCC AGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAGAGGCTGGGAAAGTGGGCCTCCCCTTGCAACTCAGAGC TGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGCTGGGTGTGTGTCAGAGGCGCAGGGTGGGTGGGGCTGC CAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTGGGGTGTGGCTAACGGCCCCTCCAGCACCCATAGCCAG GTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTAAGCTGAAGCTCCCACACTGTCTTCCAGGGCTGAGGAG ATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGCAGTTGCTGGACGGGGTAGTACTGGGAAGCAGGAGGCAGAAT >31023_31023_5_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000591858_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=522AA_BP=212 MKLILYSGTALSAPGGATPPSPLGPTEPALSRGTAASCGGLGTAGRLHRNFAIVGTGRCSFPELPRTAYFEDSLSSPGTPTAHPGLAPYF PNPAIALASRRPQRGHRGPPVPREMFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQSQGQPLASQPPVVDPYDMPGTSYS TPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILK RFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGA PTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPF -------------------------------------------------------------- >31023_31023_6_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000592436_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=2796nt_BP=599nt TTCCCCGGACAGCGTACTTTGAGGACTCGCTCAGCTCACCGGGGACTCCCACGGCTCACCCCGGACTTGCACCTTACTTCCCCAACCCGG CCATAGCCTTGGCTTCCCGGCGACCTCAGCGTGGTCACAGGGGCCCCCCTGTGCCCAGGGAAATGTTTCAGGCTTTCCCCGGAGACTACG ACTCCGGCTCCCGGTGCAGCTCCTCACCCTCTGCCGAGTCTCAATATCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCG CCTCCCAGGAGTGCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATCACAACCAGCCAGGACCTCCAGTGGC TTGTGCAACCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCCCCGGTCGTCGACCCCTACGACATGC CGGGAACCAGCTACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGTGGGCCTTCCACCAGCGGAACTACCA GTGGGCCTGGGCCTGCCCGCCCAGCCCGAGCCCGGCCTAGGAGACCCCGAGAGGAGACGAGCAAACCCTGGAAGAAGCTGAAGACAGTTC TGAAGTATTCACCCTTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACATGCTGGGAACTTCCAGGCAGGAGAGG ATGGTCGGATTCTGAAACGTTTCTGTCAGTGTGAGCAGCGCAGCCTGGAGCAGCTGATGAAAGACCCGCTGCGACCTTTCGTGCCTGCCT ACTATGGCATGGTGCTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTTGAGGGCCCCTCCATTATGGACTGCA AGATGGGCAGCAGGACCTATCTGGAAGAGGAGCTAGTGAAGGCACGGGAACGTCCCCGTCCCCGGAAGGACATGTATGAGAAGATGGTGG CTGTGGACCCTGGGGCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTACATGCAGTGGAGGGAAACCATGAGCT CCACCTCTACCCTGGGCTTCCGGATCGAGGGCATCAAGAAGGCAGATGGGACCTGTAACACCAACTTCAAGAAGACGCAGGCACTGGAGC AGGTGACAAAAGTGCTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCATGCCTAGAAGAACTTCGTGAAGCTC TGGAGATCTCCCCCTTCTTCAAGACCCACGAGGTGGTAGGCAGCTCCCTCCTCTTCGTGCACGACCACACCGGCCTGGCCAAGGTCTGGA TGATAGACTTCGGCAAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGGGCTGAGGGCAACCGTGAGGACGGCT ACCTCTGGGGCCTGGACAACATGATCTGCCTCCTGCAGGGGCTGGCACAGAGCTGAGCTGCTCAGCCACCATCAGGTTAATTGGATGGCG CCAGTCTGGCTGGAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGTTGGCCACGGGGGAGCTGGCCTCCAGGGACGGGAGAGATTGTGTC ATGTGCCACACGAGACCAACGTGGAAAAGTCTGAAGGGCCTTGGGAGACCAGGTAGCACCTGGCCCCATCATGATGCAGGGGTTTTGGGG ACCTGGAAGGAAGGTGATGAGGCAGTGAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGGGAAGGCTTCTGAGGGGCTGCCCTGA GAGCATTCAGTTCACATGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTTCTAACCTGCCTCCCTGTCAGCCTCC AGGCTGCCAGCTGGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGCATCATTGGTGAACAGATGCAGGCGC TGCTGGACCATCTGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCGACAAGAGGCTCAGAGGGCATGACCC CATGGGACTGGATGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTGTGGGATCCTCCGTGTTCCTCGGCGG ACTCTGCTGACCTCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAGCACTGTGACAGTACCTCGCTCCTCTGTGCACCAG ATCCGGCCTCAGGACTTACACCTCCTGCCTGACCCCCAGGCTTCTCTCTCCTTTCTCCCAGCAAACTGCAGTGGCAGAAAGGAGGTTCAG AGGCTGGGAAAGTGGGCCTCCCCTTGCAACTCAGAGCTGCTGCACTCAGGAGGGCCCCATCCAATCCCGGGCCCCTGCAGGGAAAAGCGC TGGGTGTGTGTCAGAGGCGCAGGGTGGGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGATCCAAACCAAAGACTGTAGAACCCTG GGGTGTGGCTAACGGCCCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGGCGGACAGGCACCTACCTCTTCCTTA AGCTGAAGCTCCCACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTGATACTTATTTATACGAGAGGCAGTT GCTGGACGGGGTAGTACTGGGAAGCAGGAGGCAGAATGGCTCTGCTGAGCCTCCTACCCATGACAACACCCCAATAAACAGAACATTCAG >31023_31023_6_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000592436_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=465AA_BP=155 MASRRPQRGHRGPPVPREMFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQ PTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETSKPWKKLKTVLKY SPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMG SRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVT KVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLW -------------------------------------------------------------- >31023_31023_7_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000592811_ITPKC_chr19_41231245_ENST00000263370_length(transcript)=3271nt_BP=1074nt AGAGAGTAGTTAAGCCTTCAGAGCAGTTCCAGGAGTCCATTTACGGGAGGGGGGAGATGAGCGCTGCTGAGGCTTGGGGGCTCAGGTCCC GCACCATTCCCCCTCCGCGACAATCTGAGAGAGCTCCAGTGGTTACTTTTATCTACCTGTCCGTTCACCCTAAACTGTCACTCGTCAGTC TCACTCTGAGAAGAGACAGTAACTTGAAACGTTGTTCTAAACTCCTAGGCCCGTCCCCCAAACACCCTTTTGACTGGGACCCCCGCCCCT GCATGGGACCTCGCGCAGAGGGGGGTGTGTATGTGTGTGAGTGTAGAGGAAGGCTTGGCCTAAGGCCTCTCCTTCTCCCTCCCCTTGCCT CTGGGGTGGGGGTGGGGTGTTGTGGCTGTGTGTGTGGCTGTGGCTCCGTCCCGGGGGTTCTGTCACCCGGCTGTGTCCAGCCTCCTCTCC ACCCCCCATACCTAAGAGTCACCAACCCGGGGTGTGATTCACCACCCGCTGGAACCGTGCAACCTTTCCCCGAGGAAGAAGGAGGAGGTA GAAGCCAGTTGAGCAGAAATCCTCTCATTAACCACTGCGTCACGGTGTAGTGGAAGGGTGGGTGTTGTGGCTTTTTCCCTGTGACACACA CATCCACACTCGCTCACCCTGTGCTCACTCACGGGGTCGGTGTGTGTTATGTGTGTTGGGTGTGTGTGTGTCGGTGTCTTTGTTTGTGTG TCTACGCCTGTGTGTGTATGTGTCACCCCGTAGGAGTGCGCCGGTCTCGGGGAAATGCCCGGTTCCTTCGTGCCCACGGTCACCGCGATC ACAACCAGCCAGGACCTCCAGTGGCTTGTGCAACCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGGGCAGCCACTGGCCTCCCAGCCC CCGGTCGTCGACCCCTACGACATGCCGGGAACCAGCTACTCCACACCAGGCATGAGTGGCTACAGCAGTGGCGGAGCGAGTGGCAGTGGT GGGCCTTCCACCAGCGGAACTACCAGTGGGCCTGGGCCTGCCCGCCCAGCCCGAGCCCGGCCTAGGAGACCCCGAGAGGAGACGAGCAAA CCCTGGAAGAAGCTGAAGACAGTTCTGAAGTATTCACCCTTTGTGGTCTCCTTCCGAAAACACTACCCTTGGGTCCAGCTTTCTGGACAT GCTGGGAACTTCCAGGCAGGAGAGGATGGTCGGATTCTGAAACGTTTCTGTCAGTGTGAGCAGCGCAGCCTGGAGCAGCTGATGAAAGAC CCGCTGCGACCTTTCGTGCCTGCCTACTATGGCATGGTGCTGCAGGATGGCCAGACCTTCAACCAGATGGAAGACCTCCTGGCTGACTTT GAGGGCCCCTCCATTATGGACTGCAAGATGGGCAGCAGGACCTATCTGGAAGAGGAGCTAGTGAAGGCACGGGAACGTCCCCGTCCCCGG AAGGACATGTATGAGAAGATGGTGGCTGTGGACCCTGGGGCCCCTACCCCTGAGGAGCATGCCCAGGGTGCAGTCACCAAGCCCCGCTAC ATGCAGTGGAGGGAAACCATGAGCTCCACCTCTACCCTGGGCTTCCGGATCGAGGGCATCAAGAAGGCAGATGGGACCTGTAACACCAAC TTCAAGAAGACGCAGGCACTGGAGCAGGTGACAAAAGTGCTGGAGGACTTCGTGGATGGAGACCACGTCATCCTGCAAAAGTACGTGGCA TGCCTAGAAGAACTTCGTGAAGCTCTGGAGATCTCCCCCTTCTTCAAGACCCACGAGGTGGTAGGCAGCTCCCTCCTCTTCGTGCACGAC CACACCGGCCTGGCCAAGGTCTGGATGATAGACTTCGGCAAGACGGTGGCCTTGCCCGACCACCAGACGCTCAGCCACAGGCTGCCCTGG GCTGAGGGCAACCGTGAGGACGGCTACCTCTGGGGCCTGGACAACATGATCTGCCTCCTGCAGGGGCTGGCACAGAGCTGAGCTGCTCAG CCACCATCAGGTTAATTGGATGGCGCCAGTCTGGCTGGAGGAGCCCTGAGATGCCATGGGAGGCCTGAGGTTGGCCACGGGGGAGCTGGC CTCCAGGGACGGGAGAGATTGTGTCATGTGCCACACGAGACCAACGTGGAAAAGTCTGAAGGGCCTTGGGAGACCAGGTAGCACCTGGCC CCATCATGATGCAGGGGTTTTGGGGACCTGGAAGGAAGGTGATGAGGCAGTGAGTCAGAAAAACCAGAACGGGGTCCCCGGATCTGCCGG GAAGGCTTCTGAGGGGCTGCCCTGAGAGCATTCAGTTCACATGTCACAGGGTATGGTGTGACAGGGTGCCTGTGGACACATGAATCACTT CTAACCTGCCTCCCTGTCAGCCTCCAGGCTGCCAGCTGGCTGAGGCCAGGGACTGGGTCAGGCTCATCTGTGGCGCCTCAGAGGGTCAGC ATCATTGGTGAACAGATGCAGGCGCTGCTGGACCATCTGGGGAGAGTGACAGTCCATGTCTTCACCAGGGAGCCATTTGAGTGCTGAGCG ACAAGAGGCTCAGAGGGCATGACCCCATGGGACTGGATGCGGCCTGAGGGCTGATACCGCTGGGCGGTATCCTGCCCTGCTGTGGCCCTG TGGGATCCTCCGTGTTCCTCGGCGGACTCTGCTGACCTCCTGCAGACCCAAACCACAGCCACATCCCAGCTTCTGTGCCAGCACTGTGAC AGTACCTCGCTCCTCTGTGCACCAGATCCGGCCTCAGGACTTACACCTCCTGCCTGACCCCCAGGCTTCTCTCTCCTTTCTCCCAGCAAA CTGCAGTGGCAGAAAGGAGGTTCAGAGGCTGGGAAAGTGGGCCTCCCCTTGCAACTCAGAGCTGCTGCACTCAGGAGGGCCCCATCCAAT CCCGGGCCCCTGCAGGGAAAAGCGCTGGGTGTGTGTCAGAGGCGCAGGGTGGGTGGGGCTGCCAGCCAGGACCCTGGCCTGCAGCCTGAT CCAAACCAAAGACTGTAGAACCCTGGGGTGTGGCTAACGGCCCCTCCAGCACCCATAGCCAGGTCTTCCTGGCCCTTGAGGCTGGGCTGG CGGACAGGCACCTACCTCTTCCTTAAGCTGAAGCTCCCACACTGTCTTCCAGGGCTGAGGAGATGCTCTCCTTTTCTACTGACCATCTTG ATACTTATTTATACGAGAGGCAGTTGCTGGACGGGGTAGTACTGGGAAGCAGGAGGCAGAATGGCTCTGCTGAGCCTCCTACCCATGACA >31023_31023_7_FOSB-ITPKC_FOSB_chr19_45974207_ENST00000592811_ITPKC_chr19_41231245_ENST00000263370_length(amino acids)=398AA_BP=88 MPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPAR ARPRRPREETSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQ TFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIE GIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVAL -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for FOSB-ITPKC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for FOSB-ITPKC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for FOSB-ITPKC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies