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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FOS-FOS (FusionGDB2 ID:31024)

Fusion Gene Summary for FOS-FOS

Fusion gene summary

Fusion gene information	Fusion gene name: FOS-FOS
	Fusion gene ID: 31024
		Hgene	Tgene
	Gene symbol	FOS	FOS
	Gene ID	2353	2353
	Gene name	Fos proto-oncogene, AP-1 transcription factor subunit	Fos proto-oncogene, AP-1 transcription factor subunit
	Synonyms	AP-1\|C-FOS\|p55	AP-1\|C-FOS\|p55
	Cytomap	14q24.3	14q24.3
	Type of gene	protein-coding	protein-coding
	Description	proto-oncogene c-FosFBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFos proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 7activator protein 1cellular o	proto-oncogene c-FosFBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFos proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 7activator protein 1cellular o
	Modification date	20200329	20200329
	UniProtAcc	P01100	P15408
	Ensembl transtripts involved in fusion gene	ENST00000303562, ENST00000555686, ENST00000535987, ENST00000555347, ENST00000554617, ENST00000555242, ENST00000556324,	ENST00000303562, ENST00000535987, ENST00000554617, ENST00000555242, ENST00000555347, ENST00000555686, ENST00000556324,
Fusion gene scores	* DoF score	6 X 9 X 1=54	10 X 13 X 3=390
	# samples	9	13
	** MAII score	log2(9/54*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/390*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FOS [Title/Abstract] AND FOS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FOS(75748643)-FOS(75748498), # samples:1 FOS(75747659)-FOS(75745716), # samples:1 FOS(75746257)-FOS(75746322), # samples:1 FOS(75748367)-FOS(75747739), # samples:1
Anticipated loss of major functional domain due to fusion event.	FOS-FOS seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. FOS-FOS seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FOS	GO:0007179	transforming growth factor beta receptor signaling pathway	9732876
Hgene	FOS	GO:0034614	cellular response to reactive oxygen species	17217916
Hgene	FOS	GO:0045893	positive regulation of transcription, DNA-templated	9732876
Hgene	FOS	GO:0045944	positive regulation of transcription by RNA polymerase II	10508860
Hgene	FOS	GO:0060395	SMAD protein signal transduction	9732876
Tgene	FOS	GO:0007179	transforming growth factor beta receptor signaling pathway	9732876
Tgene	FOS	GO:0034614	cellular response to reactive oxygen species	17217916
Tgene	FOS	GO:0045893	positive regulation of transcription, DNA-templated	9732876
Tgene	FOS	GO:0045944	positive regulation of transcription by RNA polymerase II	10508860
Tgene	FOS	GO:0060395	SMAD protein signal transduction	9732876

Fusion gene breakpoints across FOS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FOS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE710328	FOS	chr14	75748643	-	FOS	chr14	75748498	+
ChiTaRS5.0	N/A	BF089597	FOS	chr14	75747659	+	FOS	chr14	75745716	+
ChiTaRS5.0	N/A	BI046238	FOS	chr14	75746257	+	FOS	chr14	75746322	-
ChiTaRS5.0	N/A	BP215108	FOS	chr14	75748367	+	FOS	chr14	75747739	+

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Fusion Gene ORF analysis for FOS-FOS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000303562	ENST00000303562	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-3CDS	ENST00000555686	ENST00000303562	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-3UTR	ENST00000303562	ENST00000303562	FOS	chr14	75748643	-	FOS	chr14	75748498	+
3UTR-intron	ENST00000303562	ENST00000535987	FOS	chr14	75748643	-	FOS	chr14	75748498	+
3UTR-intron	ENST00000303562	ENST00000535987	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000303562	ENST00000554617	FOS	chr14	75748643	-	FOS	chr14	75748498	+
3UTR-intron	ENST00000303562	ENST00000554617	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000303562	ENST00000555242	FOS	chr14	75748643	-	FOS	chr14	75748498	+
3UTR-intron	ENST00000303562	ENST00000555242	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000303562	ENST00000555347	FOS	chr14	75748643	-	FOS	chr14	75748498	+
3UTR-intron	ENST00000303562	ENST00000555347	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000303562	ENST00000555686	FOS	chr14	75748643	-	FOS	chr14	75748498	+
3UTR-intron	ENST00000303562	ENST00000555686	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000303562	ENST00000556324	FOS	chr14	75748643	-	FOS	chr14	75748498	+
3UTR-intron	ENST00000303562	ENST00000556324	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000555686	ENST00000535987	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000555686	ENST00000554617	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000555686	ENST00000555242	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000555686	ENST00000555347	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000555686	ENST00000555686	FOS	chr14	75748367	+	FOS	chr14	75747739	+
3UTR-intron	ENST00000555686	ENST00000556324	FOS	chr14	75748367	+	FOS	chr14	75747739	+
5CDS-3UTR	ENST00000303562	ENST00000535987	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000303562	ENST00000555242	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000303562	ENST00000556324	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000535987	ENST00000535987	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000535987	ENST00000555242	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000535987	ENST00000556324	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000555347	ENST00000535987	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000555347	ENST00000555242	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000555347	ENST00000556324	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000555686	ENST00000535987	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000555686	ENST00000555242	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-3UTR	ENST00000555686	ENST00000556324	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000303562	ENST00000555347	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000303562	ENST00000555686	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000535987	ENST00000555347	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000535987	ENST00000555686	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000555347	ENST00000555347	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000555347	ENST00000555686	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000555686	ENST00000555347	FOS	chr14	75747659	+	FOS	chr14	75745716	+
5CDS-intron	ENST00000555686	ENST00000555686	FOS	chr14	75747659	+	FOS	chr14	75745716	+
Frame-shift	ENST00000303562	ENST00000303562	FOS	chr14	75747659	+	FOS	chr14	75745716	+
Frame-shift	ENST00000535987	ENST00000303562	FOS	chr14	75747659	+	FOS	chr14	75745716	+
Frame-shift	ENST00000555347	ENST00000554617	FOS	chr14	75747659	+	FOS	chr14	75745716	+
Frame-shift	ENST00000555686	ENST00000303562	FOS	chr14	75747659	+	FOS	chr14	75745716	+
In-frame	ENST00000303562	ENST00000554617	FOS	chr14	75747659	+	FOS	chr14	75745716	+
In-frame	ENST00000535987	ENST00000554617	FOS	chr14	75747659	+	FOS	chr14	75745716	+
In-frame	ENST00000555347	ENST00000303562	FOS	chr14	75747659	+	FOS	chr14	75745716	+
In-frame	ENST00000555686	ENST00000554617	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3CDS	ENST00000535987	ENST00000303562	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-3CDS	ENST00000554617	ENST00000303562	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3CDS	ENST00000554617	ENST00000303562	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-3CDS	ENST00000554617	ENST00000554617	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3CDS	ENST00000555242	ENST00000303562	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3CDS	ENST00000555242	ENST00000303562	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-3CDS	ENST00000555242	ENST00000554617	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3CDS	ENST00000555347	ENST00000303562	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-3CDS	ENST00000556324	ENST00000303562	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3CDS	ENST00000556324	ENST00000303562	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-3CDS	ENST00000556324	ENST00000554617	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000535987	ENST00000303562	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-3UTR	ENST00000554617	ENST00000303562	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-3UTR	ENST00000554617	ENST00000535987	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000554617	ENST00000555242	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000554617	ENST00000556324	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000555242	ENST00000303562	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-3UTR	ENST00000555242	ENST00000535987	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000555242	ENST00000555242	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000555242	ENST00000556324	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000555347	ENST00000303562	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-3UTR	ENST00000555686	ENST00000303562	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-3UTR	ENST00000556324	ENST00000303562	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-3UTR	ENST00000556324	ENST00000535987	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000556324	ENST00000555242	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-3UTR	ENST00000556324	ENST00000556324	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-intron	ENST00000303562	ENST00000303562	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000303562	ENST00000535987	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000303562	ENST00000554617	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000303562	ENST00000555242	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000303562	ENST00000555347	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000303562	ENST00000555686	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000303562	ENST00000556324	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000303562	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000535987	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000535987	ENST00000535987	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000535987	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000535987	ENST00000554617	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000535987	ENST00000554617	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000554617	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000535987	ENST00000555242	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000535987	ENST00000555242	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000555242	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000535987	ENST00000555347	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000535987	ENST00000555347	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000555347	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000535987	ENST00000555686	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000535987	ENST00000555686	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000555686	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000535987	ENST00000556324	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000535987	ENST00000556324	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000535987	ENST00000556324	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000554617	ENST00000303562	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000554617	ENST00000535987	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000554617	ENST00000535987	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000554617	ENST00000535987	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000554617	ENST00000554617	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000554617	ENST00000554617	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000554617	ENST00000554617	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000554617	ENST00000555242	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000554617	ENST00000555242	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000554617	ENST00000555242	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000554617	ENST00000555347	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000554617	ENST00000555347	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-intron	ENST00000554617	ENST00000555347	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000554617	ENST00000555347	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000554617	ENST00000555686	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000554617	ENST00000555686	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-intron	ENST00000554617	ENST00000555686	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000554617	ENST00000555686	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000554617	ENST00000556324	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000554617	ENST00000556324	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000554617	ENST00000556324	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555242	ENST00000303562	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555242	ENST00000535987	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555242	ENST00000535987	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555242	ENST00000535987	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555242	ENST00000554617	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555242	ENST00000554617	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555242	ENST00000554617	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555242	ENST00000555242	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555242	ENST00000555242	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555242	ENST00000555242	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555242	ENST00000555347	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555242	ENST00000555347	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-intron	ENST00000555242	ENST00000555347	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555242	ENST00000555347	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555242	ENST00000555686	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555242	ENST00000555686	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-intron	ENST00000555242	ENST00000555686	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555242	ENST00000555686	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555242	ENST00000556324	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555242	ENST00000556324	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555242	ENST00000556324	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555347	ENST00000303562	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555347	ENST00000535987	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555347	ENST00000535987	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555347	ENST00000535987	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555347	ENST00000554617	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555347	ENST00000554617	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555347	ENST00000554617	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555347	ENST00000555242	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555347	ENST00000555242	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555347	ENST00000555242	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555347	ENST00000555347	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555347	ENST00000555347	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555347	ENST00000555347	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555347	ENST00000555686	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555347	ENST00000555686	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555347	ENST00000555686	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555347	ENST00000556324	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555347	ENST00000556324	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555347	ENST00000556324	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000555686	ENST00000303562	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555686	ENST00000535987	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555686	ENST00000535987	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555686	ENST00000554617	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555686	ENST00000554617	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555686	ENST00000555242	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555686	ENST00000555242	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555686	ENST00000555347	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555686	ENST00000555347	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555686	ENST00000555686	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555686	ENST00000555686	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000555686	ENST00000556324	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000555686	ENST00000556324	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000303562	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000535987	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000556324	ENST00000535987	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000535987	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000556324	ENST00000554617	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000556324	ENST00000554617	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000554617	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000556324	ENST00000555242	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000556324	ENST00000555242	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000555242	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000556324	ENST00000555347	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000556324	ENST00000555347	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-intron	ENST00000556324	ENST00000555347	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000555347	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000556324	ENST00000555686	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000556324	ENST00000555686	FOS	chr14	75747659	+	FOS	chr14	75745716	+
intron-intron	ENST00000556324	ENST00000555686	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000555686	FOS	chr14	75748367	+	FOS	chr14	75747739	+
intron-intron	ENST00000556324	ENST00000556324	FOS	chr14	75748643	-	FOS	chr14	75748498	+
intron-intron	ENST00000556324	ENST00000556324	FOS	chr14	75746257	+	FOS	chr14	75746322	-
intron-intron	ENST00000556324	ENST00000556324	FOS	chr14	75748367	+	FOS	chr14	75747739	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for FOS-FOS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FOS-FOS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:75748643/chr14:75748498)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FOS P01100	FOS P15408
FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269\|PubMed:16055710, ECO:0000269\|PubMed:17160021, ECO:0000269\|PubMed:22105363, ECO:0000269\|PubMed:7588633, ECO:0000269\|PubMed:9732876}.	FUNCTION: Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FOS

chr14:75747659

chr14:75745716

ENST00000303562

137_200

381.0

Domain

bZIP

Tgene

FOS

chr14:75747659

chr14:75745716

ENST00000303562

139_159

381.0

Region

Note=Basic motif%3B required for the activation of phospholipid synthesis%2C but not for CDS1-binding

Tgene

FOS

chr14:75747659

chr14:75745716

ENST00000303562

165_193

381.0

Region

Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FOS

chr14:75747659

chr14:75745716

ENST00000303562

137_200

381.0

Domain

bZIP

Hgene

FOS

chr14:75747659

chr14:75745716

ENST00000303562

139_159

381.0

Region

Note=Basic motif%3B required for the activation of phospholipid synthesis%2C but not for CDS1-binding

Hgene

FOS

chr14:75747659

chr14:75745716

ENST00000303562

165_193

381.0

Region

Leucine-zipper

Top

Fusion Gene Sequence for FOS-FOS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for FOS-FOS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FOS-FOS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FOS-FOS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source