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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AHNAK-BIRC6 (FusionGDB2 ID:3105) |
Fusion Gene Summary for AHNAK-BIRC6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AHNAK-BIRC6 | Fusion gene ID: 3105 | Hgene | Tgene | Gene symbol | AHNAK | BIRC6 | Gene ID | 79026 | 57448 |
| Gene name | AHNAK nucleoprotein | baculoviral IAP repeat containing 6 | |
| Synonyms | AHNAKRS|PM227 | APOLLON|BRUCE | |
| Cytomap | 11q12.3 | 2p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokin | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q09666 | Q9NR09 | |
| Ensembl transtripts involved in fusion gene | ENST00000378024, ENST00000257247, ENST00000525875, ENST00000530124, | ENST00000421745, | |
| Fusion gene scores | * DoF score | 27 X 21 X 12=6804 | 23 X 19 X 14=6118 |
| # samples | 34 | 29 | |
| ** MAII score | log2(34/6804*10)=-4.32277648952568 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(29/6118*10)=-4.39893530154327 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AHNAK [Title/Abstract] AND BIRC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AHNAK(62283375)-BIRC6(32820101), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across AHNAK (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across BIRC6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-EE-A2GT-06A | AHNAK | chr11 | 62283375 | - | BIRC6 | chr2 | 32820101 | + |
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Fusion Gene ORF analysis for AHNAK-BIRC6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000378024 | ENST00000421745 | AHNAK | chr11 | 62283375 | - | BIRC6 | chr2 | 32820101 | + |
| intron-3CDS | ENST00000257247 | ENST00000421745 | AHNAK | chr11 | 62283375 | - | BIRC6 | chr2 | 32820101 | + |
| intron-3CDS | ENST00000525875 | ENST00000421745 | AHNAK | chr11 | 62283375 | - | BIRC6 | chr2 | 32820101 | + |
| intron-3CDS | ENST00000530124 | ENST00000421745 | AHNAK | chr11 | 62283375 | - | BIRC6 | chr2 | 32820101 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000378024 | AHNAK | chr11 | 62283375 | - | ENST00000421745 | BIRC6 | chr2 | 32820101 | + | 20855 | 18787 | 275 | 17947 | 5890 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000378024 | ENST00000421745 | AHNAK | chr11 | 62283375 | - | BIRC6 | chr2 | 32820101 | + | 0.000237308 | 0.9997627 |
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Fusion Genomic Features for AHNAK-BIRC6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| AHNAK | chr11 | 62283376 | - | BIRC6 | chr2 | 32820100 | + | 0.000596489 | 0.9994035 |
| AHNAK | chr11 | 62283376 | - | BIRC6 | chr2 | 32820100 | + | 0.000596489 | 0.9994035 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AHNAK-BIRC6 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:62283375/chr2:32820101) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AHNAK | BIRC6 |
| FUNCTION: May be required for neuronal cell differentiation. | FUNCTION: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000378024 | - | 5 | 5 | 5458_5654 | 6170 | 5891.0 | Compositional bias | Note=Gly-rich |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000378024 | - | 5 | 5 | 9_90 | 6170 | 5891.0 | Domain | PDZ |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000378024 | - | 5 | 5 | 4971_4979 | 6170 | 5891.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000378024 | - | 5 | 5 | 5019_5027 | 6170 | 5891.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000378024 | - | 5 | 5 | 5034_5039 | 6170 | 5891.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000378024 | - | 5 | 5 | 5706_5716 | 6170 | 5891.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000378024 | - | 5 | 5 | 5772_5779 | 6170 | 5891.0 | Motif | Nuclear localization signal |
| Tgene | BIRC6 | chr11:62283375 | chr2:32820101 | ENST00000421745 | 66 | 74 | 4573_4740 | 4500 | 4858.0 | Domain | UBC core |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000257247 | - | 1 | 6 | 5458_5654 | 0 | 150.0 | Compositional bias | Note=Gly-rich |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000257247 | - | 1 | 6 | 9_90 | 0 | 150.0 | Domain | PDZ |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000257247 | - | 1 | 6 | 4971_4979 | 0 | 150.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000257247 | - | 1 | 6 | 5019_5027 | 0 | 150.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000257247 | - | 1 | 6 | 5034_5039 | 0 | 150.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000257247 | - | 1 | 6 | 5706_5716 | 0 | 150.0 | Motif | Nuclear localization signal |
| Hgene | AHNAK | chr11:62283375 | chr2:32820101 | ENST00000257247 | - | 1 | 6 | 5772_5779 | 0 | 150.0 | Motif | Nuclear localization signal |
| Tgene | BIRC6 | chr11:62283375 | chr2:32820101 | ENST00000421745 | 66 | 74 | 1660_1668 | 4500 | 4858.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | BIRC6 | chr11:62283375 | chr2:32820101 | ENST00000421745 | 66 | 74 | 30_36 | 4500 | 4858.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | BIRC6 | chr11:62283375 | chr2:32820101 | ENST00000421745 | 66 | 74 | 284_358 | 4500 | 4858.0 | Repeat | Note=BIR |
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Fusion Gene Sequence for AHNAK-BIRC6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >3105_3105_1_AHNAK-BIRC6_AHNAK_chr11_62283375_ENST00000378024_BIRC6_chr2_32820101_ENST00000421745_length(transcript)=20855nt_BP=18787nt ACAAGAGCCGCCTCCGCGCACGGGGGCCCGGCCACTCGGAGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGA ACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCCTTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTG TGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGAGGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTG CAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGCTGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGG ACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCCCTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCA CCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCCAGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCA AGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCCGTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAGCGGGGATGATG AGGAGTACCAGCGCATCTACACCACGAAGATCAAGCCACGGCTGAAGTCGGAAGATGGAGTGGAAGGAGACCTCGGGGAGACCCAGAGCC GTACCATCACAGTGACCAGAAGGGTCACGGCCTACACTGTGGATGTGACTGGCCGGGAAGGAGCCAAGGACATAGACATCAGTAGCCCTG AATTCAAGATCAAGATTCCAAGACATGAACTGACTGAAATCTCCAATGTGGATGTGGAGACCCAGTCTGGGAAGACCGTGATCAGACTGC CCTCGGGCTCGGGGGCAGCCTCTCCGACAGGCTCTGCTGTGGATATCCGAGCAGGGGCCATTTCTGCTTCAGGACCAGAGCTCCAAGGTG CTGGCCACTCGAAGCTCCAGGTCACCATGCCTGGGATAAAGGTGGGAGGCTCAGGTGTCAATGTCAATGCAAAGGGCTTGGACTTGGGTG GCAGAGGAGGGGTCCAAGTTCCAGCAGTGGACATTTCATCTTCTCTTGGGGGTAGGGCAGTAGAGGTACAGGGCCCATCTCTGGAGAGTG GTGATCATGGCAAAATTAAATTTCCCACCATGAAAGTGCCGAAATTTGGTGTCTCAACAGGGCGTGAGGGCCAGACACCAAAGGCAGGGC TGAGGGTTTCTGCACCTGAAGTCTCTGTGGGGCACAAGGGCGGCAAGCCAGGCTTGACTATCCAAGCCCCTCAGCTGGAAGTCAGTGTGC CCTCTGCCAATATTGAGGGCCTTGAGGGGAAGCTGAAGGGCCCCCAAATCACTGGGCCATCACTTGAGGGTGACCTAGGCCTGAAAGGTG CCAAGCCACAGGGGCACATTGGGGTGGATGCCTCTGCTCCCCAAATTGGGGGTAGCATCACTGGCCCCAGTGTGGAAGTTCAGGCCCCTG ACATTGATGTTCAGGGGCCTGGGAGCAAACTGAATGTGCCCAAGATGAAAGTCCCCAAGTTCTCTGTATCAGGTGCAAAGGGAGAGGAAA CTGGGATTGATGTGACACTGCCTACAGGTGAAGTGACTGTTCCTGGGGTCTCTGGGGATGTCAGCCTGCCTGAGATTGCTACTGGTGGGC TGGAAGGAAAGATGAAAGGTACTAAAGTGAAGACTCCTGAAATGATTATTCAGAAACCTAAAATCTCCATGCAGGATGTGGATCTGAGCC TTGGGTCTCCTAAACTGAAAGGAGATATTAAGGTTTCTGCTCCTGGGGTGCAAGGTGATGTTAAAGGCCCTCAAGTGGCACTTAAAGGCT CCAGAGTGGACATAGAGACACCAAACCTAGAGGGAACCTTGACAGGCCCTAGGCTTGGCAGTCCTTCCGGGAAAACCGGAACCTGTAGGA TCTCTATGTCAGAAGTAGACTTAAATGTGGCCGCACCTAAAGTGAAAGGGGGTGTAGATGTCACACTCCCCAGAGTAGAAGGGAAAGTCA AAGTCCCTGAAGTTGATGTCAGAGGCCCCAAAGTGGATGTCAGTGCCCCAGATGTCGAAGCGCATGGCCCAGAATGGAACCTGAAAATGC CCAAGATGAAAATGCCCACGTTCAGCACTCCAGGAGCCAAAGGGGAAGGTCCAGATGTTCATATGACTCTACCCAAAGGAGATATCAGTA TTTCAGGGCCCAAGGTCAATGTGGAAGCCCCAGATGTCAACTTGGAGGGTCTGGGGGGAAAACTTAAAGGCCCCGATGTTAAGCTGCCTG ATATGAGTGTCAAGACACCAAAGATCTCCATGCCTGATGTAGATTTGCACGTGAAAGGTACAAAGGTGAAGGGAGAGTATGATGTAACTG TACCAAAGCTGGAAGGAGAACTCAAAGGCCCAAAAGTGGACATTGATGCCCCAGATGTGGATGTTCATGGCCCAGACTGGCACTTGAAGA TGCCCAAGATGAAAATGCCCAAATTCAGTGTGCCAGGGTTCAAAGCAGAGGGCCCAGAAGTGGATGTGAACCTGCCCAAGGCTGATGTGG ACATTTCCGGGCCCAAGATAGATGTTACTGCTCCTGATGTGAGCATTGAGGAACCAGAAGGGAAATTGAAAGGGCCCAAGTTTAAGATGC CTGAGATGAACATCAAAGTCCCCAAGATCTCCATGCCTGATGTGGACTTACATCTGAAAGGCCCTAACGTAAAGGGAGAATATGATGTCA CAATGCCAAAGGTTGAAAGTGAGATTAAAGTTCCTGATGTTGAACTTAAAAGTGCCAAAATGGACATTGATGTCCCAGATGTGGAGGTTC AAGGCCCAGACTGGCACCTGAAGATGCCCAAGATGAAAATGCCCAAGTTCAGCATGCCTGGCTTCAAAGCAGAGGGCCCAGAAGTGGATG TGAACCTGCCCAAGGCTGATGTGGACATCTCAGGACCCAAGGTGGGTGTTGAAGTTCCAGATGTGAATATTGAAGGACCTGAAGGAAAGC TGAAGGGCCCCAAGTTCAAGATGCCAGAGATGAATATCAAGGCCCCCAAGATCTCCATGCCTGATGTGGACTTGCATATGAAAGGTCCTA AAGTAAAGGGAGAATATGATATGACAGTGCCAAAGCTGGAAGGGGACCTGAAAGGCCCAAAAGTAGATGTCAGTGCCCCAGATGTTGAAA TGCAGGGTCCTGACTGGAACTTGAAGATGCCAAAGATTAAAATGCCCAAATTTAGCATGCCCAGCCTCAAAGGAGAGGGGCCAGAATTTG ATGTGAACCTGTCCAAAGCGAATGTGGACATTTCTGCACCAAAAGTAGATACTAATGCTCCAGATCTGAGCCTTGAAGGACCTGAAGGGA AGTTGAAAGGCCCGAAGTTTAAGATGCCTGAGATGCACTTCAGAGCTCCTAAGATGTCTTTGCCAGATGTTGACCTGGATCTTAAAGGAC CCAAAATGAAAGGAAATGTAGATATCTCTGCACCAAAGATAGAGGGTGAAATGCAGGTTCCAGATGTGGACATCAGAGGTCCCAAGGTAG ATATTAAAGCACCAGATGTGGAAGGCCAAGGCCTGGACTGGAGCCTGAAAATACCCAAGATGAAAATGCCCAAGTTCAGCATGCCCAGCC TCAAAGGCGAGGGCCCAGAAGTGGATGTGAACTTGCCTAAGGCTGACGTTGTTGTCTCAGGACCCAAGGTGGACATCGAAGCCCCAGATG TGAGCCTCGAAGGTCCAGAAGGGAAGCTGAAGGGTCCCAAGTTTAAGATGCCTGAGATGCATTTCAAGACCCCCAAGATCTCCATGCCTG ATGTGGACTTACACTTGAAAGGCCCCAAAGTCAAAGGGGATGTGGATGTGTCTGTGCCCAAGGTAGAAGGTGAAATGAAAGTGCCAGATG TTGAAATCAAAGGACCCAAAATGGACATTGATGCCCCAGATGTGGAGGTTCAAGGCCCAGACTGGCACCTGAAGATGCCCAAGATGAAAA TGCCCAAGTTTAGCATGCCTGGCTTCAAAGGAGAGGGCCGAGAAGTGGATGTGAACCTGCCCAAGGCTGACATTGATGTCTCAGGACCCA AGGTGGATGTTGAAGTCCCAGATGTGAGCCTTGAGGGCCCGGAAGGAAAGCTGAAGGGCCCCAAGTTTAAGATGCCTGAGATGCACTTCA AGGCCCCCAAGATCTCCATGCCTGATGTGGACCTGAATCTTAAGGGGCCAAAATTGAAGGGAGATGTGGATGTGTCCTTGCCTGAGGTAG AAGGTGAAATGAAAGTGCCAGATGTTGACATTAAAGGGCCCAAAGTTGACATTAGTGCTCCAGATGTGGATGTTCATGGCCCAGATTGGC ACCTGAAGATGCCCAAGGTGAAAATGCCCAAGTTCAGCATGCCCGGCTTCAAAGGAGAGGGCCCTGAAGTGGATGTGAAGCTGCCCAAAG CTGACGTTGATGTCTCAGGACCCAAAATGGATGCTGAAGTTCCAGATGTGAATATTGAAGGTCCAGACGCAAAACTAAAAGGTCCCAAAT TCAAGATGCCAGAAATGAGTATAAAGCCTCAGAAGATATCCATACCAGATGTTGGTTTGCATTTGAAAGGTCCTAAAATGAAAGGAGATT ATGATGTAACAGTTCCAAAAGTAGAAGGAGAGATAAAAGCTCCTGATGTTGACATCAAAGGCCCCAAAGTTGATATTAATGCACCAGATG TGGAGGTTCATGGCCCAGACTGGCACCTGAAGATGCCCAAGGTAAAAATGCCCAAGTTCAGCATGCCTGGCTTTAAAGGAGAGGGCCCAG AGGTGGATATGAACCTGCCCAAGGCTGACCTTGGTGTTTCAGGACCCAAGGTGGACATTGATGTTCCAGATGTGAATCTTGAAGCTCCAG AGGGGAAACTAAAAGGCCCTAAGTTCAAGATGCCAAGCATGAATATACAGACGCACAAAATCTCTATGCCTGATGTTGGACTTAATTTGA AAGCCCCTAAACTGAAAACTGATGTAGATGTTTCCCTTCCCAAAGTGGAAGGAGACTTGAAGGGTCCTGAAATTGATGTGAAAGCCCCTA AGATGGATGTGAATGTTGGTGATATTGATATTGAAGGTCCAGAAGGGAAGTTGAAGGGCCCCAAGTTTAAGATGCCTGAGATGCATTTCA AGGCCCCCAAGATCTCCATGCCCGATGTGGACTTACACTTGAAAGGCCCCAAAGTCAAAGGGGATATGGATGTGTCTGTGCCCAAGGTAG AAGGTGAAATGAAAGTGCCAGATGTTGACATTAAAGGGCCCAAAGTGGACATTGATGCCCCAGATGTGGAGGTTCACGACCCAGATTGGC ACCTGAAAATGCCCAAGATGAAAATGCCCAAGTTCAGTATGCCTGGCTTCAAAGCAGAGGGCCCTGAAGTGGATGTGAATCTGCCAAAGG CTGACATTGATGTGTCTGGACCCAGTGTGGACACTGATGCTCCTGATTTGGATATTGAGGGACCAGAAGGAAAGTTGAAAGGCTCCAAAT TTAAGATGCCCAAGTTGAATATAAAAGCTCCCAAGGTCTCCATGCCAGATGTGGACTTGAATTTGAAGGGACCCAAACTGAAGGGAGAGA TAGATGCTTCTGTGCCAGAACTGGAAGGTGATCTCAGAGGGCCGCAAGTTGATGTCAAAGGTCCTTTTGTGGAAGCGGAGGTGCCCGATG TTGATCTGGAGTGTCCTGATGCAAAGTTGAAAGGGCCCAAGTTTAAGATGCCTGAGATGCACTTCAAGGCCCCCAAGATCTCCATGCCTG ATGTGGACTTACACCTGAAAGGCCCCAAAGTCAAAGGGGATGCGGATGTGTCGGTGCCAAAATTGGAGGGAGATTTAACAGGCCCCAGTG TGGGTGTGGAGGTGCCTGATGTTGAGCTGGAGTGTCCTGATGCAAAGTTGAAAGGCCCTAAATTTAAGATGCCAGACATGCACTTCAAGG CCCCCAAGATCTCCATGCCTGATGTGGACTTACACTTGAAAGGCCCCAAAGTCAAAGGGGATGTGGATGTGTCGGTGCCAAAATTGGAGG GAGATTTAACAGGTCCCAGTGTGGGTGTGGAGGTGCCTGATGTTGAGCTGGAGTGTCCTGATGCAAAGTTGAAAGGGCCCAAGTTTAAGA TGCCTGAGATGCACTTCAAGACCCCCAAGATCTCCATGCCTGATGTGGACTTACACCTGAAAGGCCCCAAAGTCAAAGGGGATATGGATG TGTCTGTGCCCAAGGTAGAAGGTGAAATGAAAGTGCCAGATGTTGACATCAAAGGACCCAAAATGGACATTGATGCCCCAGATGTGGATG TTCATGGCCCAGACTGGCACCTGAAGATGCCCAAGATGAAAATGCCCAAGTTCAGCATGCCTGGCTTCAAAGCAGAGGGCCCAGAAGTGG ATGTGAACTTGCCCAAGGCTGATGTTGTTGTCTCAGGACCCAAGGTGGATGTTGAAGTCCCAGATGTGAGCCTTGAAGGTCCAGAAGGGA AGCTGAAGGGCCCCAAGCTTAAGATGCCTGAGATGCACTTCAAGGCCCCCAAGATCTCCATGCCTGATGTGGACTTACACTTGAAAGGCC CCAAAGTCAAAGGGGATGTGGATGTGTCTTTGCCAAAATTGGAGGGAGATTTAACAGGCCCCAGTGTGGATGTGGAGGTGCCTGATGTTG AGCTGGAGTGTCCTGATGCAAAGTTGAAAGGGCCCAAGTTTAAGATGCCTGAGATGCACTTCAAGACCCCCAAGATCTCCATGCCTGATG TGAACTTAAACTTGAAAGGCCCCAAAGTCAAAGGGGATATGGATGTGTCTGTTCCCAAGGTAGAAGGTGAAATGAAAGTGCCAGATGTTG ACATCAGAGGGCCCAAAGTGGACATTGATGCCCCAGATGTGGATGTTCATGGCCCAGACTGGCACCTGAAGATGCCTAAGATGAAAATGC CCAAGTTCAGCATGCCTGGCTTCAAAGGAGAGGGCCCAGAAGTGGATGTGAACTTGCCCAAGGCTGACGTTGATGTCTCAGGACCCAAGG TGGATGTTGAAGTCCCAGATGTGAGCCTTGAAGGTCCAGAAGGGAAGCTGAAGGGCCCCAAGTTTAAGATGCCTGAGATGCACTTCAAGA CCCCCAAGATCTCCATGCCTGATGTTGATTTCAATTTAAAGGGACCCAAAATCAAAGGAGATGTTGATGTTTCTGCCCCAAAGCTGGAGG GAGAGTTAAAAGGTCCAGAATTGGATGTCAAAGGTCCCAAATTAGATGCTGACATGCCAGAAGTAGCTGTGGAAGGCCCAAATGGCAAGT GGAAAACTCCTAAGTTCAAGATGCCAGATATGCACTTTAAAGCTCCCAAAATCTCTATGCCAGACCTCGATCTACACTTGAAGAGCCCCA AGGCAAAAGGAGAGGTGGATGTAGATGTTCCCAAATTGGAAGGGGACCTTAAAGGGCCACATGTGGATGTCAGTGGGCCAGACATTGACA TTGAGGGACCAGAGGGCAAATTGAAAGGCCCTAAGTTCAAGATGCCTGATATGCATTTCAAAGCCCCCAATATTTCTATGCCTGATGTTG ATCTAAATCTCAAAGGACCCAAAATCAAGGGGGATGTGGATGTGTCTGTGCCTGAGGTAGAAGGTAAACTTGAAGTACCAGATATGAACA TCAGGGGCCCCAAAGTTGATGTAAATGCCCCCGATGTCCAAGCTCCAGACTGGCACCTGAAGATGCCCAAGATGAAAATGCCCAAGTTCA GCATGCCTGGCTTCAAAGCAGAGGGCCCTGAAGTAGACGTCAACTTGCCTAAGGCTGACGTTGACATCTCAGGACCCAAGGTGGACATTG AAGGCCCTGATGTTAATATTGAAGGACCAGAGGGAAAGTTGAAAGGGCCTAAGTTAAAGATGCCAGAGATGAACATCAAAGCCCCCAAGA TCTCCATGCCTGACTTTGATTTGCATCTGAAAGGTCCCAAGGTGAAGGGCGATGTGGATGTTTCTCTGCCCAAAGTGGAAGGTGACCTCA AGGGCCCCGAAGTTGACATCAAGGGGCCCAAAGTGGATATTAATGCCCCAGATGTGGGTGTTCAAGGCCCAGACTGGCACCTGAAGATGC CCAAGGTGAAAATGCCAAAGTTCAGCATGCCTGGCTTCAAAGGAGAGGGCCCAGATGGGGATGTGAAGCTGCCCAAGGCTGACATTGATG TCTCAGGACCCAAAGTGGACATTGAAGGCCCTGATGTTAACATTGAAGGACCAGAGGGAAAGTTGAAAGGGCCTAAGTTCAAGATGCCAG AGATGAATATCAAAGCCCCCAAGATCTCCATGCCTGATATTGACTTAAACCTGAAAGGACCCAAAGTGAAGGGTGATGTGGATGTTTCCC TTCCTAAAGTGGAAGGTGACCTCAAGGGCCCAGAAGTTGACATCAAGGGCCCAAAAGTGGACATTGACGCACCTGATGTTGATGTTCATG GCCCAGACTGGCACCTAAAGATGCCCAAGATAAAAATGCCCAAGATCAGCATGCCTGGCTTCAAAGGAGAAGGTCCAGATGTGGACGTGA ACCTGCCCAAGGCTGACATTGATGTCTCAGGACCGAAAGTGGATGTTGAATGTCCCGATGTGAATATCGAAGGACCTGAAGGAAAGTGGA AAAGTCCAAAGTTTAAGATGCCAGAGATGCATTTTAAGACTCCAAAGATATCCATGCCAGATATTGACCTGAATCTCACAGGTCCAAAAA TAAAAGGAGATGTGGATGTTACAGGCCCTAAGGTAGAGGGAGATCTGAAAGGTCCTGAAGTTGACCTCAAAGGCCCCAAAGTGGACATTG ATGTCCCAGATGTTAATGTTCAGGGTCCAGACTGGCACCTGAAGATGCCCAAGATGAAAATGCCCAAGTTCAGCATGCCTGGCTTCAAAG CAGAGGGCCCTGAAGTGGATGTGAACCTGCCCAAGGCTGACGTTGATGTCTCAGGCCCCAAAGTGGACGTTGAAGGCCCTGATGTTAACA TTGAAGGACCAGAGGGAAAGTTGAAAGGGCCCAAGTTCAAGATGCCAGAGATGAATATCAAAGCCCCCAAGATCCCCATGCCTGACTTTG ATTTGCATCTGAAAGGTCCCAAGGTGAAGGGCGATGTGGATATTTCTCTGCCCAAAGTGGAAGGTGACCTCAAGGGCCCTGAAGTTGACA TCAGGGGTCCCCAAGTGGACATTGATGTCCCGGATGTGGGCGTTCAAGGCCCAGACTGGCACCTAAAAATGCCCAAAGTGAAAATGCCCA AATTCAGCATGCCTGGCTTCAAAGGAGAGGGCCCAGATGTGGATGTGAACCTGCCCAAGGCTGACCTTGATGTCTCAGGACCCAAGGTGG ACATTGATGTTCCAGATGTGAATATCGAAGGCCCAGAGGGAAAGTTGAAAGGTCCCAAATTCAAAATGCCTGAGATGAACATCAAAGCCC CCAAGATCTCCATGCCTGACATTGATCTTAACCTGAAAGGTCCCAAAGTGAAGGGTGACATGGATGTGTCTCTGCCAAAAGTGGAAGGTG ACATGAAAGTTCCTGACGTGGATATTAAAGGCCCCAAAGTGGATATTAATGCCCCAGATGTGGATGTTCAAGGCCCAGACTGGCACCTGA AGATGCCTAAAATAAAAATGCCCAAGATCAGCATGCCTGGCTTCAAAGGAGAAGGTCCAGAAGTGGACGTGAACCTGCCCAAGGCTGACC TTGACGTCTCAGGACCCAAGGTGGACGTTGATGTTCCAGATGTGAATATTGAAGGTCCAGATGCGAAACTGAAGGGCCCTAAATTCAAGA TGCCAGAGATGAACATCAAAGCTCCTAAAATATCAATGCCTGATTTGGACCTCAATCTTAAAGGCCCTAAAATGAAAGGAGAGGTGGATG TTTCACTTGCAAATGTAGAAGGTGATTTGAAAGGACCTGCTCTTGACATAAAAGGCCCAAAGATAGATGTAGATGCTCCAGATATTGACA TTCATGGCCCAGATGCCAAATTAAAAGGTCCAAAACTGAAGATGCCTGACATGCATGTAAACATGCCCAAGATCTCCATGCCAGAAATTG ACTTGAATTTGAAAGGCTCAAAGCTTAAGGGAGATGTTGATGTCTCTGGGCCCAAGTTGGAAGGTGACATTAAAGCTCCCAGTTTGGATA TAAAGGGCCCAGAAGTGGACGTTTCCGGTCCTAAGCTTAATATCGAAGGCAAGTCAAAGAAATCTCGTTTTAAGCTTCCCAAATTTAATT TTTCGGGCTCTAAAGTTCAGACACCTGAAGTGGATGTCAAAGGTAAAAAGCCAGATATTGACATAACAGGTCCAAAAGTTGATATTAATG CTCCTGATGTCGAGGTCCAAGGAAAAGTGAAAGGATCCAAGTTTAAAATGCCTTTCCTGAGTATTTCATCTCCCAAAGTTTCTATGCCTG ACGTGGAGCTAAATTTGAAAAGTCCCAAAGTCAAAGGAGACTTAGATATTGCAGGTCCCAATTTAGAAGGTGACTTTAAAGGCCCCAAAG TGGATATTAAGGCACCAGAAGTCAATCTTAATGCACCTGATGTGGATGTTCATGGTCCAGACTGGAATCTGAAAATGCCCAAGATGAAAA TGCCCAAATTCAGTGTGTCTGGCTTAAAAGCAGAAGGGCCAGATGTAGCTGTGGATCTACCAAAAGGAGACATCAACATAGAGGGCCCAA GTATGAACATTGAGGGCCCAGATCTCAATGTGGAAGGTCCGGAGGGAGGCTTGAAAGGTCCCAAATTCAAGATGCCTGACATGAATATCA AAGCTCCCAAGATCTCCATGCCTGACATTGACTTAAACTTGAAAGGCCCCAAGGTGAAAGGTGATGTGGATATTTCTCTTCCCAAACTTG AAGGGGATCTGAAAGGGCCAGAGGTTGATATCAAAGGCCCTAAAGTGGACATCAATGCCCCAGATGTGGATGTTCATGGTCCAGACTGGC ATCTGAAGATGCCCAAAGTGAAAATGCCCAAGTTCAGCATGCCTGGCTTCAAAGGAGAAGGCCCTGAAGTCGATGTTACCCTCCCTAAAG CTGACATTGACATTTCTGGTCCCAATGTAGACGTTGATGTTCCAGACGTGAATATTGAAGGTCCAGATGCAAAGCTGAAGGGCCCCAAGT TCAAGATGCCTGAGATGAACATCAAAGCCCCCAAGATCTCCATGCCTGACTTTGACCTGAACTTGAAGGGACCCAAAATGAAGGGTGATG TGGTTGTGTCTTTGCCCAAAGTGGAAGGTGATCTAAAAGGCCCTGAGGTGGACATCAAGGGCCCCAAAGTGGACATTGACACTCCTGACA TTAACATCGAAGGCTCAGAGGGTAAATTCAAGGGACCCAAATTTAAGATACCAGAGATGCACCTGAAGGCTCCCAAAATATCGATGCCTG ACATTGATTTAAACCTGAAGGGCCCCAAAGTCAAGGGCGATGTGGATGTTTCTCTGCCCAAAATGGAAGGTGACCTCAAGGGTCCTGAAG TTGACATCAAGGGCCCCAAAGTGGACATTAATGCTCCAGATGTTGATGTTCAAGGCCCAGACTGGCACCTGAAGATGCCCAAGGTGAAAA TGCCCAAGTTCAGCATGCCTGGCTTCAAAGGAGAGGGCCCAGATGTGGATGTGAACCTGCCCAAGGCTGACCTTGATGTCTCAGGACCCA AGGTGGACATTGATGTTCCAGATGTGAATATCGAAGGCCCAGAGGGAAAGTTGAAAGGTCCCAAATTCAAGATGCCTGAGATGAACATCA AAGCCCCCAAGATCTCCATGCCTGACATTGATCTTAACCTGAAAGGACCCAAAGTGAAGGGTGATATGGATGTGTCTCTGCCAAAAGTGG AAGGTGACATGCAAGTTCCTGACTTGGATATTAAAGGCCCCAAAGTGGATATTAATGCCCCAGATGTGGATGTTCGAGGCCCAGACTGGC ACCTGAAGATGCCTAAGATAAAAATGCCCAAGATCAGCATGCCTGGCTTCAAAGGAGAAGGTCCAGAAGTGGATGTGAACCTGCCCAAGG CTGACCTTGACGTCTCAGGACCCAAGGTGGACGTTGATGTTCCAGATGTGAATATTGAAGGTCCAGATGCGAAACTGAAGGGCCCTAAAT TCAAGATGCCAGAGATGAACATCAAAGCCCCCAAGATCTCCATGCCTGACTTTGATTTGCATCTGAAAGGCCCTAAGGTGAAAGGAGATG TGGATGTTTCTCTGCCTAAGATGGAAGGTGATCTAAAGGCCCCTGAAGTTGACATCAAGGGCCCCAAAGTGGACATTGATGCCCCAGATG TGGATGTTCATGGCCCAGACTGGCACCTGAAGATGCCCAAGGTGAAAATGCCCAAATTCAGCATGCCAGGATTTAAAGGAGAGGGCCCAG AAGTGGATGTTAATTTGCCCAAAGCTGACATTGATGTCTCAGGACCCAAAGTGGACATTGACACTCCTGATATTGATATTCATGGTCCAG AAGGGAAACTGAAGGGCCCCAAATTTAAAATGCCTGACCTGCACCTCAAGGCACCGAAGATCTCTATGCCTGAAGTTGACCTGAATCTGA AAGGTCCAAAGATGAAGGGCGACGTGGACGTTTCTCTGCCCAAAGTGGAAGGCGACCTCAAGGGCCCTGAAGTTGACATCAAGGGCCCCA AAGTGGACATTGATGTCCCAGATGTGGACGTTCAAGGCCCAGACTGGCACTTAAAAATGCCCAAAGTGAAAATGCCCAAGTTCAGCATGC CTGGCTTCAAAGGAGAGGGCCCAGATGTGGATGTGAACCTGCCCAAGGCTGACCTTGACGTCTCAGGACCCAAGGTGGACATTGATGTTC CTGATGTGAATATCGAAGGTCCAGATGCGAAACTAAAGGGCCCTAAATTCAAGATGCCTGAGATGAACATCAAAGCCCCCAAGATCTCCA TGCCTGACTTTGATTTGCATCTGAAAGGTCCCAAGGTGAAGGGTGATGTGGATGTTTCCCTTCCTAAAGTGGAAGGTGACCTCAAGGGCC CAGAAGTTGACATCAAGGGCCCCAAAGTGGACATCGATGCCCCTGATGTAGATGTTCATGGCCCAGACTGGCACCTGAAGATGCCCAAGG TGAAAATGCCCAAATTCAGCATGCCAGGATTCAAAGGAGAGGGCCCAGATGTGGATGTTACCCTTCCTAAGGCTGACATTGAGATTTCTG GCCCCAAAGTGGACATTGATGCCCCTGATGTCAGTATCGAAGGTCCAGATGCAAAACTCAAGGGTCCAAAGTTCAAGATGCCAGAGATGA ACATCAAGGCCCCCAAAATCTCCATGCCTGACATTGACTTTAACTTGAAGGGTCCCAAAGTGAAAGGTGATGTGGATGTCTCTCTGCCCA AAGTGGAAGGTGATCTCAAGGGCCCTGAAATTGACATAAAAGGCCCCAGTTTGGACATTGACACACCTGATGTCAATATTGAAGGTCCGG AAGGAAAATTGAAGGGGCCCAAATTTAAGATGCCTGAGATGAACATCAAAGCTCCCAAAATCTCTATGCCTGACTTTGATTTGCACCTGA AAGGTCCCAAGGTGAAGGGTGATGTGGATGTTTCACTACCTAAGGTGGAAAGTGATCTGAAAGGGCCAGAGGTAGACATTGAAGGTCCTG AAGGGAAGCTCAAAGGTCCCAAGTTTAAGATGCCTGATGTACATTTCAAAAGCCCACAAATCTCCATGAGTGACATTGATTTGAATTTGA AAGGACCTAAGATAAAAGGAGATATGGACATTTCCGTTCCTAAACTGGAGGGAGATCTGAAAGGTCCCAAAGTGGATGTCAAAGGCCCTA AAGTGGGCATTGACACTCCTGATATTGACATTCATGGTCCAGAAGGGAAACTGAAGGGCCCCAAATTTAAAATGCCTGACTTACACCTCA AGGCACCGAAGATCTCTATGCCTGAAGTTGACCTGAATCTGAAAGGTCCAAAGGTGAAGGGCGACATGGACATTTCTCTGCCCAAAGTGG AAGGCGACCTCAAGGGCCCCGAAGTTGACATCAGGGACCCCAAAGTGGACATTGATGTCCCAGATGTGGACGTTCAAGGCCCAGACTGGC ACCTAAAAATGCCCAAAGTGAAAATGCCCAAGTTCAGCATGCCTGGCTTCAAAGGAGAGGGCCCAGATGTGGATGTGAACCTGCCCAAGG CTGACATTGATGTCTCAGGACCCAAAGTGGACGTTGATGTTCCTGATGTGAATATCGAAGGTCCAGATGCGAAACTAAAGGGCCCCAAGT TCAAGATGCCTGAGATGAGCATCAAAGCCCCCAAGATCTCCATGCCTGATATTGACTTAAACCTGAAAGGACCCAAAGTGAAGGGCGATG TGGATGTTACCCTTCCTAAAGTGGAAGGTGACCTCAAGGGCCCAGAAGCTGACATCAAGGGCCCAAAAGTGGACATCAACACCCCTGATG TGGATGTTCATGGCCCAGACTGGCACCTGAAGATGCCCAAGGTGAAAATGCCCAAATTCAGCATGCCTGGCTTCAAAGGAGAAGGTCCAG ATGTGGATGTGAGCCTGCCCAAGGCCGACATCGATGTCTCGGGACCCAAGGTGGACGTTGATATTCCAGATGTGAATATCGAAGGTCCAG ACGCAAAACTGAAGGGCCCCAAGTTCAAGATGCCTGAAATAAATATCAAAGCTCCCAAGATCTCCATACCTGATGTTGACCTGGATTTGA AAGGACCCAAAGTAAAAGGAGATTTTGATGTGTCTGTCCCTAAGGTTGAAGGGACTTTGAAAGGCCCAGAAGTAGATCTTAAAGGTCCAC GTCTGGATTTCGAAGGCCCTGATGCCAAACTCAGTGGCCCATCTTTGAAGATGCCATCGCTGGAGATATCTGCTCCTAAAGTAACTGCTC CTGATGTTGATTTGCATCTCAAGGCACCAAAAATTGGATTTTCAGGTCCGAAGTTAGAAGGTGGTGAAGTGGACCTCAAGGGACCCAAAG TTGAAGCTCCAAGCTTAGATGTACACATGGACAGCCCAGATATTAACATCGAAGGGCCAGATGTTAAAATCCCCAAATTTAAGAAACCCA AGTTTGGATTTGGGGCAAAAAGCCCCAAAGCTGACATCAAGTCACCTTCACTGGATGTCACTGTTCCTGAGGCAGAGCTGAACCTTGAGA CTCCTGAAATTAGTGTTGGTGGCAAGGGCAAGAAAAGTAAGTTTAAAATGCCTAAAATTCATATGAGTGGTCCTAAGATTAAGGCCAAAA AACAGGGATTTGACCTGAATGTTCCTGGGGGTGAAATTGATGCCAGCCTCAAGGCTCCGGATGTAGATGTCAACATCGCAGGGCCGGATG CTGCACTCAAAGTCGACGTGAAATCGCCCAAAACCAAGAAAACGATGTTTGGAAAAATGTACTTCCCAGATGTAGAGTTTGACATTAAAT CACCTAAATTTAAAGCTGAGGCCCCTCTCCCTAGCCCCAAACTGGAGGGTGAACTCCAGGCACCTGATCTGGAACTTTCTTTGCCAGCGA TTCACGTCGAAGGTCTTGACATCAAGGCGAAGGCTCCCAAGGTCAAGATGCCAGATGTGGACATCTCAGTGCCAAAAATAGAGGGTGACC TGAAAGGCCCCAAAGTGCAGGCAAACTTGGGTGCACCTGACATCAACATCGAAGGCCTAGATGCTAAAGTCAAAACACCGTCCTTCGGCA TTTCTGCCCCTCAAGTCTCCATCCCTGATGTGAATGTAAACTTGAAAGGACCAAAGATAAAGGGTGATGTCCCCAGCGTGGGACTGGAAG GACCAGATGTAGATCTGCAAGGTCCAGAAGCAAAAATTAAGTTCCCCAAGTTTTCCATGCCCAAGATCGGCATCCCAGGTGTGAAAATGG AGGGTGGGGGAGCCGAGGTCCATGCCCAGCTACCCTCTCTTGAAGGAGACTTGAGAGGACCAGATGTTAAGCTCGAAGGGCCCGATGTTT CTCTAAAGGGGCCAGGAGTAGACTTGCCTTCAGTGAACCTCTCTATGCCAAAAGTCTCTGGGCCTGACCTTGATCTGAACTTGAAAGGAC CAAGTTTGAAGGGAGACCTGGATGCATCTGTTCCCAGCATGAAGGTGCATGCTCCAGGGCTCAACCTCAGTGGTGTCGGTGGCAAAATGC AGGTGGGAGGAGACGGTGTGAAAGTGCCAGGGATCGATGCCACAACAAAGCTTAACGTTGGGGCACCAGATGTGACACTGAGGGGACCAA GCCTGCAGGGAGATCTGGCTGTCTCTGGTGACATCAAATGCCCTAAAGTATCCGTAGGAGCTCCTGATCTAAGCTTGGAGGCATCCGAAG GCAGCATTAAACTTCCCAAAATGAAGCTGCCCCAATTTGGCATCTCTACTCCGGGGTCCGACTTGCACGTCAATGCCAAGGGGCCACAGG TTTCTGGCGAACTGAAGGGGCCAGGTGTGGATGTGAACCTGAAAGGGCCTCGGATTTCAGCACCGAATGTGGACTTTAACTTGGAAGGAC CAAAAGTGAAAGGGAGCCTTGGGGCCACTGGTGAGATCAAAGGCCCCACTGTCGGAGGAGGTCTTCCAGGCATTGGTGTTCAAGGCCTAG AAGGAAACCTCCAGATGCCTGGAATTAAGTCCTCTGGATGTGATGTGAACCTGCCAGGCGTGAATGTGAAACTCCCAACTGGGCAGATTT CTGGGCCTGAAATCAAAGGTGGTCTGAAAGGTTCAGAAGTAGGTTTCCATGGGGCTGCTCCTGATATCAGTGTGAAGGGGCCTGCCTTTA ATATGGCATCTCCTGAGTCAGATTTTGGCATCAACTTGAAGGGCCCAAAAATCAAAGGAGGTGCGGATGTTTCAGGGGGTGTCAGTGCCC CAGACATCAGCCTTGGTGAAGGGCATTTGAGTGTTAAAGGTTCCGGGGGTGAGTGGAAGGGACCCCAAGTCTCCTCTGCTCTCAACTTGG ACACATCTAAGTTTGCTGGGGGCCTTCATTTCTCAGGACCAAAGGTGGAAGGAGGTGTGAAAGGAGGTCAGATTGGACTCCAGGCTCCTG GGCTGAGTGTGTCTGGGCCTCAAGGTCACTTGGAAAGTGGATCTGGAAAAGTAACATTCCCTAAAATGAAGATCCCCAAATTTACCTTCT CTGGCCGTGAGCTGGTTGGCAGAGAAATGGGGGTGGATGTTCACTTCCCTAAAGCAGAGGCCAGCATCCAAGCTGGTGCTGGAGACGGCG AGTGGGAAGAGTCTGAAGTCAAACTGAAAAAGTCCAAGATCAAAATGCCCAAGTTTAATTTTTCCAAACCTAAAGGGAAAGGTGGTGTCA CTGGCTCACCAGAAGCATCAATTTCTGGGTCCAAAGGTGACCTGAAAAGTTCAAAGGCCAGCCTGGGCTCTCTGGAAGGAGAGGCAGAGG CCGAAGCCTCTTCACCGAAAGGCAAATTCTCCTTATTTAAAAGTAAGAAGCCACGGCACCGCTCAAATTCATTCAGTGATGAAAGAGAGT TCTCTGGACCTTCCACCCCGACGGGGACGCTGGAGTTTGAAGGTGGGGAAGTGTCTCTGGAAGGTGGGAAAGTTAAAGGGAAACACGGGA AGCTGAAATTCGGTACCTTTGGTGGATTGGGGTCAAAGAGCAAAGGTCATTATGAGGTGACTGGGAGCGATGATGAGACAGGCAAGTTAC AGGGGAGTGGGGTGTCCCTGGCCTCTAAGAAGTCCCGACTGTCCTCCTCTTCTAGCAATGACAGTGGGAATAAGGTTGGCATCCAGCTTC CCGAGGTGGAGCTGTCAGTTTCCACAAAGAAAGAGTAGCAGGCCTTTGTATGTGTGTACATATATATATATATAACAAAACATCAGCCTT GGGTGGTGTGTTCCTATATAAACTCCAAAGGGAAACACACCGACTGCCTCAGCAATCATGCAAAGACCTTGCCTGGCCCGGTGGCAAGCG CTGAAAAACCGACCGCCTGTAGGCTCCTGGAACTATACAGATAGGTAAAGAGTTCCAAGTTCGTCCAGCCCATGTGCAAAGTCAACAGTA TTTGCCTTAAGATTTCATATATATATATTTTTTTGCATTGACTGCTGAGAGCTCCTGTTTACTAAGCAAGCTTTTGTGTTTATTATCCTC ATTTTTACTGAACATTGTTAGTTTTGGGGTAATGGAAACCCACTTTTTCATTGTAATGACTTTGGGGGCTTTTGTTAGTAAGGGTGGGTG GGGTGATGGGTTGCAGACGGAGGTCAGGTCTTCCTCTTTCCTGAGACTGGATCTGTTCAAACAGCAAACGCCCACAGATGGCCCAGAGGT GGTGGTAGTCAGGGTGTGTGGGTGTTTTTAGGGTTCTTTAGTGTTGTTTCTTTCACCCAGGGGTGGTGGTCCCAGCCAGTTTGGTGCTGA CGGTGAGAGGAAATTAGAATCTGTTTGCAAATTGTCCAACCCACCCCCTCAACATGAGGGGCTTCCATTTTCTGTGTTTTGTAAGGGAAC TGTTTCCTTCATGCCGCCATGTTCCTGATATTAGTTCTGATTTCTTTTTAACAAATGTTATCATGATTAAGAAAATTTCCAGCACTTTAA TGGCCAATTAACTGAGAATGTAAGAAAATTGATGCTGTACAAGGCAAATAAAGCTGTTTATTAACCTAAAAAAAACTGGGTGAATACTCC AAGAAGGCGGCTATGAAACCCAAACCTTTGTCAGTATTAAAGTCACTTGAAGAAAAATATGTGGCTGTTATGAAGAAATTACAGTTTGAT ACGTTTGAAATGGTTTCTGAAGATGAAGATGGGAAATTGGGATTTAAAGTAAATTACCACTACATGTCTCAGGTGAAAAATGCTAATGAT GCGAACAGTGCTGCCAGAGCTCGCCGCCTTGCCCAGGAAGCTGTGACGCTTTCAACCTCACTGCCTCTGTCTTCATCCTCTAGTGTGTTT GTACGCTGTGATGAGGAGCGACTTGATATCATGAAGGTTCTAATAACTGGTCCAGCGGACACCCCTTATGCAAATGGCTGCTTTGAGTTT GATGTGTATTTTCCTCAAGATTATCCCAGTTCACCCCCTCTTGTGAATCTAGAGACAACTGGTGGTCATAGCGTGCGATTCAATCCAAAC CTTTATAATGATGGCAAGGTTTGTTTAAGCATCTTAAACACGTGGCATGGAAGACCAGAAGAGAAGTGGAATCCTCAGACCTCAAGCTTT TTGCAAGTGTTGGTGTCTGTCCAGTCCCTTATATTAGTAGCTGAGCCTTATTTTAATGAACCGGGATATGAACGGTCTAGAGGCACTCCC AGTGGCACACAGAGTTCTCGAGAATATGATGGAAACATTCGACAAGCAACAGTTAAGTGGGCAATGCTAGAACAAATCAGAAACCCTTCA CCATGTTTTAAAGAGGTAATACACAAACATTTTTACTTGAAAAGAGTTGAGATAATGGCCCAATGTGAGGAGTGGATTGCGGATATCCAG CAGTACAGCAGTGATAAGCGGGTAGGCAGGACTATGTCTCACCATGCAGCAGCTCTCAAGCGTCACACTGCTCAGCTCCGCGAAGAGTTG CTGAAACTTCCCTGCCCTGAAGGCTTGGATCCTGACACTGACGATGCCCCAGAGGTGTGCAGAGCCACAACAGGTGCTGAGGAGACTCTA ATGCATGATCAGGTTAAACCCAGCAGCAGCAAAGAACTCCCCAGTGACTTCCAGTTATGAGCTGCATTGATGTGGACTTCATAGACACAA AGGCTTCGAAGCACAAGCCAAATATGTCAATATTTGTATGTAAGAAACTAATTATGTAATAGGTAATGAAACTGAAACTATACTATGCCC TTAAGGAGATCCAGTTTAATTCAAGGTGATCTTTTATTTACCTGTACAGGAGTGTAAACTTTTTTGTGCTTTTATTTTTCAATTGTGAGA ACCACTGATTGGTATGTTCAACAAATTTGTGTATACAAAGAAATGGATAAATCACTGCTATATAAGGGAAACTACCTTAGGAAAGAATGT TTACTGAATGTTTATTTTATTTTATTTTTTTTTTACTATAGAGTGAGGGGTTGTTAACAAAGAATATATATTGGTCATTCTTACAACTAC TATTTAAAGTCAGCAACTTTTCACTGAATTTGATAGATTTTATGTTTGGCCATATCTTCATGCTCACATTTGATTTCTGAAGACCTCCTA CATACACTTCAATAAAAGTTAAATGGACATACTCCCTCTTTTTTGATTTACTGGTACATTTTTAAAATAATAAATCTGCCATAAAATGCA TTATATCTGGAGACTTGCACTTGTATGGATGAATTTATTACATTCAACATATTTAATTTTATGCCTTCTAATTCTAAGATGCAGAAAAAA ATAAATGAACATGATTTTATTCTATGCCAACATTTGGGCCTCTGAATGTATCTGTTATTTGAATTTAAGTATTTGAAAAGGAATGGTCAA TTTGAAAGTCATTCTAAACTGATTTTTTTTTTCTAAAGGGCTCCTTTTTTCCTGGACTATGTGGTTTTATGACTAAAGTCACATGTATGT ATTAAACATTGAGGCTCTGTAGAGGAGAGAGGATGTACCTCTCTGGTGCTGTTACAGTACATTCTGTACCTGCCATACAGGCTCATTTTC >3105_3105_1_AHNAK-BIRC6_AHNAK_chr11_62283375_ENST00000378024_BIRC6_chr2_32820101_ENST00000421745_length(amino acids)=5890AA_BP= MEKEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVTQNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKG DRSPEPGQTWTREVFSSCSSEVVLSGDDEEYQRIYTTKIKPRLKSEDGVEGDLGETQSRTITVTRRVTAYTVDVTGREGAKDIDISSPEF KIKIPRHELTEISNVDVETQSGKTVIRLPSGSGAASPTGSAVDIRAGAISASGPELQGAGHSKLQVTMPGIKVGGSGVNVNAKGLDLGGR GGVQVPAVDISSSLGGRAVEVQGPSLESGDHGKIKFPTMKVPKFGVSTGREGQTPKAGLRVSAPEVSVGHKGGKPGLTIQAPQLEVSVPS ANIEGLEGKLKGPQITGPSLEGDLGLKGAKPQGHIGVDASAPQIGGSITGPSVEVQAPDIDVQGPGSKLNVPKMKVPKFSVSGAKGEETG IDVTLPTGEVTVPGVSGDVSLPEIATGGLEGKMKGTKVKTPEMIIQKPKISMQDVDLSLGSPKLKGDIKVSAPGVQGDVKGPQVALKGSR VDIETPNLEGTLTGPRLGSPSGKTGTCRISMSEVDLNVAAPKVKGGVDVTLPRVEGKVKVPEVDVRGPKVDVSAPDVEAHGPEWNLKMPK MKMPTFSTPGAKGEGPDVHMTLPKGDISISGPKVNVEAPDVNLEGLGGKLKGPDVKLPDMSVKTPKISMPDVDLHVKGTKVKGEYDVTVP KLEGELKGPKVDIDAPDVDVHGPDWHLKMPKMKMPKFSVPGFKAEGPEVDVNLPKADVDISGPKIDVTAPDVSIEEPEGKLKGPKFKMPE MNIKVPKISMPDVDLHLKGPNVKGEYDVTMPKVESEIKVPDVELKSAKMDIDVPDVEVQGPDWHLKMPKMKMPKFSMPGFKAEGPEVDVN LPKADVDISGPKVGVEVPDVNIEGPEGKLKGPKFKMPEMNIKAPKISMPDVDLHMKGPKVKGEYDMTVPKLEGDLKGPKVDVSAPDVEMQ GPDWNLKMPKIKMPKFSMPSLKGEGPEFDVNLSKANVDISAPKVDTNAPDLSLEGPEGKLKGPKFKMPEMHFRAPKMSLPDVDLDLKGPK MKGNVDISAPKIEGEMQVPDVDIRGPKVDIKAPDVEGQGLDWSLKIPKMKMPKFSMPSLKGEGPEVDVNLPKADVVVSGPKVDIEAPDVS LEGPEGKLKGPKFKMPEMHFKTPKISMPDVDLHLKGPKVKGDVDVSVPKVEGEMKVPDVEIKGPKMDIDAPDVEVQGPDWHLKMPKMKMP KFSMPGFKGEGREVDVNLPKADIDVSGPKVDVEVPDVSLEGPEGKLKGPKFKMPEMHFKAPKISMPDVDLNLKGPKLKGDVDVSLPEVEG EMKVPDVDIKGPKVDISAPDVDVHGPDWHLKMPKVKMPKFSMPGFKGEGPEVDVKLPKADVDVSGPKMDAEVPDVNIEGPDAKLKGPKFK MPEMSIKPQKISIPDVGLHLKGPKMKGDYDVTVPKVEGEIKAPDVDIKGPKVDINAPDVEVHGPDWHLKMPKVKMPKFSMPGFKGEGPEV DMNLPKADLGVSGPKVDIDVPDVNLEAPEGKLKGPKFKMPSMNIQTHKISMPDVGLNLKAPKLKTDVDVSLPKVEGDLKGPEIDVKAPKM DVNVGDIDIEGPEGKLKGPKFKMPEMHFKAPKISMPDVDLHLKGPKVKGDMDVSVPKVEGEMKVPDVDIKGPKVDIDAPDVEVHDPDWHL KMPKMKMPKFSMPGFKAEGPEVDVNLPKADIDVSGPSVDTDAPDLDIEGPEGKLKGSKFKMPKLNIKAPKVSMPDVDLNLKGPKLKGEID ASVPELEGDLRGPQVDVKGPFVEAEVPDVDLECPDAKLKGPKFKMPEMHFKAPKISMPDVDLHLKGPKVKGDADVSVPKLEGDLTGPSVG VEVPDVELECPDAKLKGPKFKMPDMHFKAPKISMPDVDLHLKGPKVKGDVDVSVPKLEGDLTGPSVGVEVPDVELECPDAKLKGPKFKMP EMHFKTPKISMPDVDLHLKGPKVKGDMDVSVPKVEGEMKVPDVDIKGPKMDIDAPDVDVHGPDWHLKMPKMKMPKFSMPGFKAEGPEVDV NLPKADVVVSGPKVDVEVPDVSLEGPEGKLKGPKLKMPEMHFKAPKISMPDVDLHLKGPKVKGDVDVSLPKLEGDLTGPSVDVEVPDVEL ECPDAKLKGPKFKMPEMHFKTPKISMPDVNLNLKGPKVKGDMDVSVPKVEGEMKVPDVDIRGPKVDIDAPDVDVHGPDWHLKMPKMKMPK FSMPGFKGEGPEVDVNLPKADVDVSGPKVDVEVPDVSLEGPEGKLKGPKFKMPEMHFKTPKISMPDVDFNLKGPKIKGDVDVSAPKLEGE LKGPELDVKGPKLDADMPEVAVEGPNGKWKTPKFKMPDMHFKAPKISMPDLDLHLKSPKAKGEVDVDVPKLEGDLKGPHVDVSGPDIDIE GPEGKLKGPKFKMPDMHFKAPNISMPDVDLNLKGPKIKGDVDVSVPEVEGKLEVPDMNIRGPKVDVNAPDVQAPDWHLKMPKMKMPKFSM PGFKAEGPEVDVNLPKADVDISGPKVDIEGPDVNIEGPEGKLKGPKLKMPEMNIKAPKISMPDFDLHLKGPKVKGDVDVSLPKVEGDLKG PEVDIKGPKVDINAPDVGVQGPDWHLKMPKVKMPKFSMPGFKGEGPDGDVKLPKADIDVSGPKVDIEGPDVNIEGPEGKLKGPKFKMPEM NIKAPKISMPDIDLNLKGPKVKGDVDVSLPKVEGDLKGPEVDIKGPKVDIDAPDVDVHGPDWHLKMPKIKMPKISMPGFKGEGPDVDVNL PKADIDVSGPKVDVECPDVNIEGPEGKWKSPKFKMPEMHFKTPKISMPDIDLNLTGPKIKGDVDVTGPKVEGDLKGPEVDLKGPKVDIDV PDVNVQGPDWHLKMPKMKMPKFSMPGFKAEGPEVDVNLPKADVDVSGPKVDVEGPDVNIEGPEGKLKGPKFKMPEMNIKAPKIPMPDFDL HLKGPKVKGDVDISLPKVEGDLKGPEVDIRGPQVDIDVPDVGVQGPDWHLKMPKVKMPKFSMPGFKGEGPDVDVNLPKADLDVSGPKVDI DVPDVNIEGPEGKLKGPKFKMPEMNIKAPKISMPDIDLNLKGPKVKGDMDVSLPKVEGDMKVPDVDIKGPKVDINAPDVDVQGPDWHLKM PKIKMPKISMPGFKGEGPEVDVNLPKADLDVSGPKVDVDVPDVNIEGPDAKLKGPKFKMPEMNIKAPKISMPDLDLNLKGPKMKGEVDVS LANVEGDLKGPALDIKGPKIDVDAPDIDIHGPDAKLKGPKLKMPDMHVNMPKISMPEIDLNLKGSKLKGDVDVSGPKLEGDIKAPSLDIK GPEVDVSGPKLNIEGKSKKSRFKLPKFNFSGSKVQTPEVDVKGKKPDIDITGPKVDINAPDVEVQGKVKGSKFKMPFLSISSPKVSMPDV ELNLKSPKVKGDLDIAGPNLEGDFKGPKVDIKAPEVNLNAPDVDVHGPDWNLKMPKMKMPKFSVSGLKAEGPDVAVDLPKGDINIEGPSM NIEGPDLNVEGPEGGLKGPKFKMPDMNIKAPKISMPDIDLNLKGPKVKGDVDISLPKLEGDLKGPEVDIKGPKVDINAPDVDVHGPDWHL KMPKVKMPKFSMPGFKGEGPEVDVTLPKADIDISGPNVDVDVPDVNIEGPDAKLKGPKFKMPEMNIKAPKISMPDFDLNLKGPKMKGDVV VSLPKVEGDLKGPEVDIKGPKVDIDTPDINIEGSEGKFKGPKFKIPEMHLKAPKISMPDIDLNLKGPKVKGDVDVSLPKMEGDLKGPEVD IKGPKVDINAPDVDVQGPDWHLKMPKVKMPKFSMPGFKGEGPDVDVNLPKADLDVSGPKVDIDVPDVNIEGPEGKLKGPKFKMPEMNIKA PKISMPDIDLNLKGPKVKGDMDVSLPKVEGDMQVPDLDIKGPKVDINAPDVDVRGPDWHLKMPKIKMPKISMPGFKGEGPEVDVNLPKAD LDVSGPKVDVDVPDVNIEGPDAKLKGPKFKMPEMNIKAPKISMPDFDLHLKGPKVKGDVDVSLPKMEGDLKAPEVDIKGPKVDIDAPDVD VHGPDWHLKMPKVKMPKFSMPGFKGEGPEVDVNLPKADIDVSGPKVDIDTPDIDIHGPEGKLKGPKFKMPDLHLKAPKISMPEVDLNLKG PKMKGDVDVSLPKVEGDLKGPEVDIKGPKVDIDVPDVDVQGPDWHLKMPKVKMPKFSMPGFKGEGPDVDVNLPKADLDVSGPKVDIDVPD VNIEGPDAKLKGPKFKMPEMNIKAPKISMPDFDLHLKGPKVKGDVDVSLPKVEGDLKGPEVDIKGPKVDIDAPDVDVHGPDWHLKMPKVK MPKFSMPGFKGEGPDVDVTLPKADIEISGPKVDIDAPDVSIEGPDAKLKGPKFKMPEMNIKAPKISMPDIDFNLKGPKVKGDVDVSLPKV EGDLKGPEIDIKGPSLDIDTPDVNIEGPEGKLKGPKFKMPEMNIKAPKISMPDFDLHLKGPKVKGDVDVSLPKVESDLKGPEVDIEGPEG KLKGPKFKMPDVHFKSPQISMSDIDLNLKGPKIKGDMDISVPKLEGDLKGPKVDVKGPKVGIDTPDIDIHGPEGKLKGPKFKMPDLHLKA PKISMPEVDLNLKGPKVKGDMDISLPKVEGDLKGPEVDIRDPKVDIDVPDVDVQGPDWHLKMPKVKMPKFSMPGFKGEGPDVDVNLPKAD IDVSGPKVDVDVPDVNIEGPDAKLKGPKFKMPEMSIKAPKISMPDIDLNLKGPKVKGDVDVTLPKVEGDLKGPEADIKGPKVDINTPDVD VHGPDWHLKMPKVKMPKFSMPGFKGEGPDVDVSLPKADIDVSGPKVDVDIPDVNIEGPDAKLKGPKFKMPEINIKAPKISIPDVDLDLKG PKVKGDFDVSVPKVEGTLKGPEVDLKGPRLDFEGPDAKLSGPSLKMPSLEISAPKVTAPDVDLHLKAPKIGFSGPKLEGGEVDLKGPKVE APSLDVHMDSPDINIEGPDVKIPKFKKPKFGFGAKSPKADIKSPSLDVTVPEAELNLETPEISVGGKGKKSKFKMPKIHMSGPKIKAKKQ GFDLNVPGGEIDASLKAPDVDVNIAGPDAALKVDVKSPKTKKTMFGKMYFPDVEFDIKSPKFKAEAPLPSPKLEGELQAPDLELSLPAIH VEGLDIKAKAPKVKMPDVDISVPKIEGDLKGPKVQANLGAPDINIEGLDAKVKTPSFGISAPQVSIPDVNVNLKGPKIKGDVPSVGLEGP DVDLQGPEAKIKFPKFSMPKIGIPGVKMEGGGAEVHAQLPSLEGDLRGPDVKLEGPDVSLKGPGVDLPSVNLSMPKVSGPDLDLNLKGPS LKGDLDASVPSMKVHAPGLNLSGVGGKMQVGGDGVKVPGIDATTKLNVGAPDVTLRGPSLQGDLAVSGDIKCPKVSVGAPDLSLEASEGS IKLPKMKLPQFGISTPGSDLHVNAKGPQVSGELKGPGVDVNLKGPRISAPNVDFNLEGPKVKGSLGATGEIKGPTVGGGLPGIGVQGLEG NLQMPGIKSSGCDVNLPGVNVKLPTGQISGPEIKGGLKGSEVGFHGAAPDISVKGPAFNMASPESDFGINLKGPKIKGGADVSGGVSAPD ISLGEGHLSVKGSGGEWKGPQVSSALNLDTSKFAGGLHFSGPKVEGGVKGGQIGLQAPGLSVSGPQGHLESGSGKVTFPKMKIPKFTFSG RELVGREMGVDVHFPKAEASIQAGAGDGEWEESEVKLKKSKIKMPKFNFSKPKGKGGVTGSPEASISGSKGDLKSSKASLGSLEGEAEAE ASSPKGKFSLFKSKKPRHRSNSFSDEREFSGPSTPTGTLEFEGGEVSLEGGKVKGKHGKLKFGTFGGLGSKSKGHYEVTGSDDETGKLQG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AHNAK-BIRC6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AHNAK-BIRC6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AHNAK-BIRC6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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