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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AHNAK-DPF2 (FusionGDB2 ID:3108)

Fusion Gene Summary for AHNAK-DPF2

check button Fusion gene summary
Fusion gene informationFusion gene name: AHNAK-DPF2
Fusion gene ID: 3108
HgeneTgene
Gene symbol

AHNAK

DPF2

Gene ID

79026

5977

Gene nameAHNAK nucleoproteindouble PHD fingers 2
SynonymsAHNAKRS|PM227CSS7|REQ|UBID4|ubi-d4
Cytomap

11q12.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionneuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokinzinc finger protein ubi-d4BAF45DBRG1-associated factor 45DD4, zinc and double PHD fingers family 2apoptosis response zinc finger proteinprotein requiemrequiem, apoptosis response zinc finger
Modification date2020032720200313
UniProtAcc

Q09666

Q92785

Ensembl transtripts involved in fusion geneENST00000257247, ENST00000378024, 
ENST00000530124, ENST00000525875, 
ENST00000532264, ENST00000252268, 
ENST00000415073, ENST00000528416, 
Fusion gene scores* DoF score27 X 21 X 12=68048 X 7 X 7=392
# samples 3410
** MAII scorelog2(34/6804*10)=-4.32277648952568
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHNAK [Title/Abstract] AND DPF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAHNAK(62259204)-DPF2(65116321), # samples:3
Anticipated loss of major functional domain due to fusion event.AHNAK-DPF2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
AHNAK-DPF2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
AHNAK-DPF2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AHNAK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8276-01AAHNAKchr11

62259204

-DPF2chr11

65116321

+
ChimerDB4LUSCTCGA-85-8276AHNAKchr11

62259203

-DPF2chr11

65116320

+
ChimerDB4LUSCTCGA-85-8276AHNAKchr11

62259204

-DPF2chr11

65116321

+
ChimerDB4LUSCTCGA-85-8276AHNAKchr11

62302475

-DPF2chr11

65116321

+


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Fusion Gene ORF analysis for AHNAK-DPF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257247ENST00000532264AHNAKchr11

62259204

-DPF2chr11

65116321

+
5CDS-intronENST00000257247ENST00000532264AHNAKchr11

62259203

-DPF2chr11

65116320

+
5CDS-intronENST00000257247ENST00000532264AHNAKchr11

62302475

-DPF2chr11

65116321

+
5CDS-intronENST00000378024ENST00000532264AHNAKchr11

62302475

-DPF2chr11

65116321

+
5CDS-intronENST00000530124ENST00000532264AHNAKchr11

62302475

-DPF2chr11

65116321

+
5UTR-3CDSENST00000525875ENST00000252268AHNAKchr11

62259204

-DPF2chr11

65116321

+
5UTR-3CDSENST00000525875ENST00000252268AHNAKchr11

62259203

-DPF2chr11

65116320

+
5UTR-3CDSENST00000525875ENST00000415073AHNAKchr11

62259204

-DPF2chr11

65116321

+
5UTR-3CDSENST00000525875ENST00000415073AHNAKchr11

62259203

-DPF2chr11

65116320

+
5UTR-3CDSENST00000525875ENST00000528416AHNAKchr11

62259204

-DPF2chr11

65116321

+
5UTR-3CDSENST00000525875ENST00000528416AHNAKchr11

62259203

-DPF2chr11

65116320

+
5UTR-intronENST00000525875ENST00000532264AHNAKchr11

62259204

-DPF2chr11

65116321

+
5UTR-intronENST00000525875ENST00000532264AHNAKchr11

62259203

-DPF2chr11

65116320

+
Frame-shiftENST00000257247ENST00000252268AHNAKchr11

62302475

-DPF2chr11

65116321

+
Frame-shiftENST00000257247ENST00000415073AHNAKchr11

62302475

-DPF2chr11

65116321

+
Frame-shiftENST00000257247ENST00000528416AHNAKchr11

62302475

-DPF2chr11

65116321

+
Frame-shiftENST00000378024ENST00000252268AHNAKchr11

62302475

-DPF2chr11

65116321

+
Frame-shiftENST00000378024ENST00000415073AHNAKchr11

62302475

-DPF2chr11

65116321

+
Frame-shiftENST00000378024ENST00000528416AHNAKchr11

62302475

-DPF2chr11

65116321

+
In-frameENST00000257247ENST00000252268AHNAKchr11

62259204

-DPF2chr11

65116321

+
In-frameENST00000257247ENST00000252268AHNAKchr11

62259203

-DPF2chr11

65116320

+
In-frameENST00000257247ENST00000415073AHNAKchr11

62259204

-DPF2chr11

65116321

+
In-frameENST00000257247ENST00000415073AHNAKchr11

62259203

-DPF2chr11

65116320

+
In-frameENST00000257247ENST00000528416AHNAKchr11

62259204

-DPF2chr11

65116321

+
In-frameENST00000257247ENST00000528416AHNAKchr11

62259203

-DPF2chr11

65116320

+
In-frameENST00000530124ENST00000252268AHNAKchr11

62302475

-DPF2chr11

65116321

+
In-frameENST00000530124ENST00000415073AHNAKchr11

62302475

-DPF2chr11

65116321

+
In-frameENST00000530124ENST00000528416AHNAKchr11

62302475

-DPF2chr11

65116321

+
intron-3CDSENST00000378024ENST00000252268AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-3CDSENST00000378024ENST00000252268AHNAKchr11

62259203

-DPF2chr11

65116320

+
intron-3CDSENST00000378024ENST00000415073AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-3CDSENST00000378024ENST00000415073AHNAKchr11

62259203

-DPF2chr11

65116320

+
intron-3CDSENST00000378024ENST00000528416AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-3CDSENST00000378024ENST00000528416AHNAKchr11

62259203

-DPF2chr11

65116320

+
intron-3CDSENST00000525875ENST00000252268AHNAKchr11

62302475

-DPF2chr11

65116321

+
intron-3CDSENST00000525875ENST00000415073AHNAKchr11

62302475

-DPF2chr11

65116321

+
intron-3CDSENST00000525875ENST00000528416AHNAKchr11

62302475

-DPF2chr11

65116321

+
intron-3CDSENST00000530124ENST00000252268AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-3CDSENST00000530124ENST00000252268AHNAKchr11

62259203

-DPF2chr11

65116320

+
intron-3CDSENST00000530124ENST00000415073AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-3CDSENST00000530124ENST00000415073AHNAKchr11

62259203

-DPF2chr11

65116320

+
intron-3CDSENST00000530124ENST00000528416AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-3CDSENST00000530124ENST00000528416AHNAKchr11

62259203

-DPF2chr11

65116320

+
intron-intronENST00000378024ENST00000532264AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-intronENST00000378024ENST00000532264AHNAKchr11

62259203

-DPF2chr11

65116320

+
intron-intronENST00000525875ENST00000532264AHNAKchr11

62302475

-DPF2chr11

65116321

+
intron-intronENST00000530124ENST00000532264AHNAKchr11

62259204

-DPF2chr11

65116321

+
intron-intronENST00000530124ENST00000532264AHNAKchr11

62259203

-DPF2chr11

65116320

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257247AHNAKchr1162259204-ENST00000528416DPF2chr1165116321+23276785892196
ENST00000257247AHNAKchr1162259204-ENST00000415073DPF2chr1165116321+2266678236697153
ENST00000257247AHNAKchr1162259204-ENST00000252268DPF2chr1165116321+20616785892196
ENST00000257247AHNAKchr1162259203-ENST00000528416DPF2chr1165116320+23276785892196
ENST00000257247AHNAKchr1162259203-ENST00000415073DPF2chr1165116320+2266678236697153
ENST00000257247AHNAKchr1162259203-ENST00000252268DPF2chr1165116320+20616785892196
ENST00000530124AHNAKchr1162302475-ENST00000528416DPF2chr1165116321+20003519509166
ENST00000530124AHNAKchr1162302475-ENST00000415073DPF2chr1165116321+19393515660189
ENST00000530124AHNAKchr1162302475-ENST00000252268DPF2chr1165116321+17343515660188

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257247ENST00000528416AHNAKchr1162259204-DPF2chr1165116321+0.044469480.9555305
ENST00000257247ENST00000415073AHNAKchr1162259204-DPF2chr1165116321+0.0451822540.9548178
ENST00000257247ENST00000252268AHNAKchr1162259204-DPF2chr1165116321+0.0376555320.9623445
ENST00000257247ENST00000528416AHNAKchr1162259203-DPF2chr1165116320+0.044469480.9555305
ENST00000257247ENST00000415073AHNAKchr1162259203-DPF2chr1165116320+0.0451822540.9548178
ENST00000257247ENST00000252268AHNAKchr1162259203-DPF2chr1165116320+0.0376555320.9623445
ENST00000530124ENST00000528416AHNAKchr1162302475-DPF2chr1165116321+0.101170830.89882916
ENST00000530124ENST00000415073AHNAKchr1162302475-DPF2chr1165116321+0.094531330.9054687
ENST00000530124ENST00000252268AHNAKchr1162302475-DPF2chr1165116321+0.082460590.9175394

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Fusion Genomic Features for AHNAK-DPF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AHNAKchr1162302474-DPF2chr1165116320+0.0015423840.9984577
AHNAKchr1162259203-DPF2chr1165116320+2.87E-081
AHNAKchr1162259203-DPF2chr1165116320+2.87E-081
AHNAKchr1162302474-DPF2chr1165116320+0.0015423840.9984577
AHNAKchr1162259203-DPF2chr1165116320+2.87E-081
AHNAKchr1162259203-DPF2chr1165116320+2.87E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AHNAK-DPF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:62259204/chr11:65116321)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHNAK

Q09666

DPF2

Q92785

FUNCTION: May be required for neuronal cell differentiation.FUNCTION: Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHNAKchr11:62259203chr11:65116320ENST00000257247-569_90147150.0DomainPDZ
HgeneAHNAKchr11:62259204chr11:65116321ENST00000257247-569_90147150.0DomainPDZ
HgeneAHNAKchr11:62302475chr11:65116321ENST00000257247-469_90114150.0DomainPDZ
HgeneAHNAKchr11:62302475chr11:65116321ENST00000378024-459_901145891.0DomainPDZ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHNAKchr11:62259203chr11:65116320ENST00000257247-565458_5654147150.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259203chr11:65116320ENST00000378024-155458_565405891.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259204chr11:65116321ENST00000257247-565458_5654147150.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259204chr11:65116321ENST00000378024-155458_565405891.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62302475chr11:65116321ENST00000257247-465458_5654114150.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62302475chr11:65116321ENST00000378024-455458_56541145891.0Compositional biasNote=Gly-rich
HgeneAHNAKchr11:62259203chr11:65116320ENST00000378024-159_9005891.0DomainPDZ
HgeneAHNAKchr11:62259204chr11:65116321ENST00000378024-159_9005891.0DomainPDZ
HgeneAHNAKchr11:62259203chr11:65116320ENST00000257247-564971_4979147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000257247-565019_5027147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000257247-565034_5039147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000257247-565706_5716147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000257247-565772_5779147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000378024-154971_497905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000378024-155019_502705891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000378024-155034_503905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000378024-155706_571605891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259203chr11:65116320ENST00000378024-155772_577905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000257247-564971_4979147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000257247-565019_5027147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000257247-565034_5039147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000257247-565706_5716147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000257247-565772_5779147150.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000378024-154971_497905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000378024-155019_502705891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000378024-155034_503905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000378024-155706_571605891.0MotifNuclear localization signal
HgeneAHNAKchr11:62259204chr11:65116321ENST00000378024-155772_577905891.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000257247-464971_4979114150.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000257247-465019_5027114150.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000257247-465034_5039114150.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000257247-465706_5716114150.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000257247-465772_5779114150.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000378024-454971_49791145891.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000378024-455019_50271145891.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000378024-455034_50391145891.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000378024-455706_57161145891.0MotifNuclear localization signal
HgeneAHNAKchr11:62302475chr11:65116321ENST00000378024-455772_57791145891.0MotifNuclear localization signal
TgeneDPF2chr11:62259203chr11:65116320ENST00000528416811209_232339392.0Zinc fingerC2H2-type
TgeneDPF2chr11:62259203chr11:65116320ENST00000528416811270_330339392.0Zinc fingerPHD-type 1
TgeneDPF2chr11:62259203chr11:65116320ENST00000528416811327_377339392.0Zinc fingerPHD-type 2
TgeneDPF2chr11:62259204chr11:65116321ENST00000528416811209_232339392.0Zinc fingerC2H2-type
TgeneDPF2chr11:62259204chr11:65116321ENST00000528416811270_330339392.0Zinc fingerPHD-type 1
TgeneDPF2chr11:62259204chr11:65116321ENST00000528416811327_377339392.0Zinc fingerPHD-type 2
TgeneDPF2chr11:62302475chr11:65116321ENST00000528416811209_232339392.0Zinc fingerC2H2-type
TgeneDPF2chr11:62302475chr11:65116321ENST00000528416811270_330339392.0Zinc fingerPHD-type 1
TgeneDPF2chr11:62302475chr11:65116321ENST00000528416811327_377339392.0Zinc fingerPHD-type 2


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Fusion Gene Sequence for AHNAK-DPF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3108_3108_1_AHNAK-DPF2_AHNAK_chr11_62259203_ENST00000257247_DPF2_chr11_65116320_ENST00000252268_length(transcript)=2061nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGACCAGTTGCTCTTCTGTGATGACTGCGATCGTGGCTACCAC
ATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCACCTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCC
ATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATCTAAGGCTGTTTCTCTCCTCCACTTCATATTTCA
TACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGGTTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTG
AGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACACTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTC
TCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATCACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGT
GGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCTGTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGG
GAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATAGCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGC
GGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCACCCTCCTGGTTCTGCCCTGTCCCATTCCACCCCA
CCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCTTACGGTCGGTCTCCAGTGACTGAAGCATTCCCC
ACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGAGAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCT
CGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTACCTCCAAAATCCCCTTTTTGTTCTTCCTGGACC
TGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTGTATCCTGGCTCTCAGCTCATGGGGAAGCCACAT
AGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCTGATTCCTCAAGTTTTCTGCTTAGTGGCACTGAC
ATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTGGCCGTGGGCAGGCCCTAACTCACTGTCGCTTTG

>3108_3108_1_AHNAK-DPF2_AHNAK_chr11_62259203_ENST00000257247_DPF2_chr11_65116320_ENST00000252268_length(amino acids)=196AA_BP=
MWCVQNHFRAAGAEDFTGPGLARLGRAVPLAVQLQAHRVVPHGVQQLGHLTRLQVVKVDGGTHNLVPLLDHPSAGRRGVLRHLLHKDAVV
PLGDGQPVGATTLPVGQQQLPGCLLLLHLCRIPLRSECLARSPPLLPLFPSVSLVGNLGHNLRAQPQGTAIAGARPKAAVLRLLAATSPV

--------------------------------------------------------------
>3108_3108_2_AHNAK-DPF2_AHNAK_chr11_62259203_ENST00000257247_DPF2_chr11_65116320_ENST00000415073_length(transcript)=2266nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGACCAGTTGCTCTTCTGTGATGACTGCGATCGTGGCTACCAC
ATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCACCTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCC
ATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATCTAAGGCTGTTTCTCTCCTCCACTTCATATTTCA
TACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGGTTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTG
AGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACACTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTC
TCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATCACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGT
GGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCTGTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGG
GAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATAGCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGC
GGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCACCCTCCTGGTTCTGCCCTGTCCCATTCCACCCCA
CCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCTTACGGTCGGTCTCCAGTGACTGAAGCATTCCCC
ACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGAGAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCT
CGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTACCTCCAAAATCCCCTTTTTGTTCTTCCTGGACC
TGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTGTATCCTGGCTCTCAGCTCATGGGGAAGCCACAT
AGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCTGATTCCTCAAGTTTTCTGCTTAGTGGCACTGAC
ATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTGGCCGTGGGCAGGCCCTAACTCACTGTCGCTTTG
GAGTTGAGGTGTCTTTTTTTTTTCTTTCTTTAGTTCCTGTATTCTAAACATTAGTAAAAATAAATGTTTTTACACAGAGCCCTCTGCTGG
ATGGTTTATCTCCTGCCTTTCTCCATTAAGAAGGCCATTTCATCCTAAGATTTCCATGATGGTGGTTTTTTTTTTTAATGTTTTGAAATA
CAGCTTTTTTCCCCCCAAATTAAAATTTTTTTGTGGAACCCCAATATGTAAAGCGAATATAAAATTGGTTATTTTGTTTTGTTACATAAA

>3108_3108_2_AHNAK-DPF2_AHNAK_chr11_62259203_ENST00000257247_DPF2_chr11_65116320_ENST00000415073_length(amino acids)=153AA_BP=
MEKEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVTQNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKG

--------------------------------------------------------------
>3108_3108_3_AHNAK-DPF2_AHNAK_chr11_62259203_ENST00000257247_DPF2_chr11_65116320_ENST00000528416_length(transcript)=2327nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGACCAGTTGCTCTTCTGTGATGACTGCGATCGTGGCTACCAC
ATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCACCTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCC
ATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATCTAAGGCTGTTTCTCTCCTCCACTTCATATTTCA
TACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGGTTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTG
AGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACACTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTC
TCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATCACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGT
GGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCTGTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGG
GAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATAGCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGC
GGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCACCCTCCTGGTTCTGCCCTGTCCCATTCCACCCCA
CCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCTTACGGTCGGTCTCCAGTGACTGAAGCATTCCCC
ACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGAGAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCT
CGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTACCTCCAAAATCCCCTTTTTGTTCTTCCTGGACC
TGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTGTATCCTGGCTCTCAGCTCATGGGGAAGCCACAT
AGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCTGATTCCTCAAGTTTTCTGCTTAGTGGCACTGAC
ATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTGGCCGTGGGCAGGCCCTAACTCACTGTCGCTTTG
GAGTTGAGGTGTCTTTTTTTTTTCTTTCTTTAGTTCCTGTATTCTAAACATTAGTAAAAATAAATGTTTTTACACAGAGCCCTCTGCTGG
ATGGTTTATCTCCTGCCTTTCTCCATTAAGAAGGCCATTTCATCCTAAGATTTCCATGATGGTGGTTTTTTTTTTTAATGTTTTGAAATA
CAGCTTTTTTCCCCCCAAATTAAAATTTTTTTGTGGAACCCCAATATGTAAAGCGAATATAAAATTGGTTATTTTGTTTTGTTACATAAA

>3108_3108_3_AHNAK-DPF2_AHNAK_chr11_62259203_ENST00000257247_DPF2_chr11_65116320_ENST00000528416_length(amino acids)=196AA_BP=
MWCVQNHFRAAGAEDFTGPGLARLGRAVPLAVQLQAHRVVPHGVQQLGHLTRLQVVKVDGGTHNLVPLLDHPSAGRRGVLRHLLHKDAVV
PLGDGQPVGATTLPVGQQQLPGCLLLLHLCRIPLRSECLARSPPLLPLFPSVSLVGNLGHNLRAQPQGTAIAGARPKAAVLRLLAATSPV

--------------------------------------------------------------
>3108_3108_4_AHNAK-DPF2_AHNAK_chr11_62259204_ENST00000257247_DPF2_chr11_65116321_ENST00000252268_length(transcript)=2061nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGACCAGTTGCTCTTCTGTGATGACTGCGATCGTGGCTACCAC
ATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCACCTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCC
ATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATCTAAGGCTGTTTCTCTCCTCCACTTCATATTTCA
TACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGGTTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTG
AGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACACTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTC
TCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATCACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGT
GGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCTGTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGG
GAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATAGCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGC
GGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCACCCTCCTGGTTCTGCCCTGTCCCATTCCACCCCA
CCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCTTACGGTCGGTCTCCAGTGACTGAAGCATTCCCC
ACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGAGAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCT
CGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTACCTCCAAAATCCCCTTTTTGTTCTTCCTGGACC
TGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTGTATCCTGGCTCTCAGCTCATGGGGAAGCCACAT
AGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCTGATTCCTCAAGTTTTCTGCTTAGTGGCACTGAC
ATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTGGCCGTGGGCAGGCCCTAACTCACTGTCGCTTTG

>3108_3108_4_AHNAK-DPF2_AHNAK_chr11_62259204_ENST00000257247_DPF2_chr11_65116321_ENST00000252268_length(amino acids)=196AA_BP=
MWCVQNHFRAAGAEDFTGPGLARLGRAVPLAVQLQAHRVVPHGVQQLGHLTRLQVVKVDGGTHNLVPLLDHPSAGRRGVLRHLLHKDAVV
PLGDGQPVGATTLPVGQQQLPGCLLLLHLCRIPLRSECLARSPPLLPLFPSVSLVGNLGHNLRAQPQGTAIAGARPKAAVLRLLAATSPV

--------------------------------------------------------------
>3108_3108_5_AHNAK-DPF2_AHNAK_chr11_62259204_ENST00000257247_DPF2_chr11_65116321_ENST00000415073_length(transcript)=2266nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGACCAGTTGCTCTTCTGTGATGACTGCGATCGTGGCTACCAC
ATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCACCTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCC
ATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATCTAAGGCTGTTTCTCTCCTCCACTTCATATTTCA
TACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGGTTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTG
AGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACACTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTC
TCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATCACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGT
GGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCTGTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGG
GAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATAGCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGC
GGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCACCCTCCTGGTTCTGCCCTGTCCCATTCCACCCCA
CCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCTTACGGTCGGTCTCCAGTGACTGAAGCATTCCCC
ACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGAGAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCT
CGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTACCTCCAAAATCCCCTTTTTGTTCTTCCTGGACC
TGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTGTATCCTGGCTCTCAGCTCATGGGGAAGCCACAT
AGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCTGATTCCTCAAGTTTTCTGCTTAGTGGCACTGAC
ATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTGGCCGTGGGCAGGCCCTAACTCACTGTCGCTTTG
GAGTTGAGGTGTCTTTTTTTTTTCTTTCTTTAGTTCCTGTATTCTAAACATTAGTAAAAATAAATGTTTTTACACAGAGCCCTCTGCTGG
ATGGTTTATCTCCTGCCTTTCTCCATTAAGAAGGCCATTTCATCCTAAGATTTCCATGATGGTGGTTTTTTTTTTTAATGTTTTGAAATA
CAGCTTTTTTCCCCCCAAATTAAAATTTTTTTGTGGAACCCCAATATGTAAAGCGAATATAAAATTGGTTATTTTGTTTTGTTACATAAA

>3108_3108_5_AHNAK-DPF2_AHNAK_chr11_62259204_ENST00000257247_DPF2_chr11_65116321_ENST00000415073_length(amino acids)=153AA_BP=
MEKEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVTQNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKG

--------------------------------------------------------------
>3108_3108_6_AHNAK-DPF2_AHNAK_chr11_62259204_ENST00000257247_DPF2_chr11_65116321_ENST00000528416_length(transcript)=2327nt_BP=678nt
AGCTGCTCTGCCGCGGGGACTGCACCGCCCGCCCTGCCAGACCCGCCCGGAACGGGGCTCGTCGCCGCCAGTAGCCGCAGCACCGCAGCC
TTGGGCCTCGCGCCGGCTATGGCCGTGCCCTGGGGCTGAGCCCTCAGGTTGTGACCGAGATTCCCGACGAGAGAGACTGAGGGGAAGAGA
GGAAGGAGGGGCGGGCTCCTGGCAAGGCATTCGCTCCTGAGCGGAATCCTGCAAAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGC
TGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAGAGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCC
CTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGTGCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCC
AGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCACCGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCC
GTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGAACACACCACAGCCATCAGCACTGGAATGCAAAGACCAGAACAAACAGAAGG
AAGCCAGCAGCCAAGCCGGGGCAGTTTCAGTCTCCACCCCAAATGCAGGACCAGTTGCTCTTCTGTGATGACTGCGATCGTGGCTACCAC
ATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCACCTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCC
ATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATCTAAGGCTGTTTCTCTCCTCCACTTCATATTTCA
TACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGGTTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTG
AGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACACTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTC
TCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATCACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGT
GGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCTGTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGG
GAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATAGCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGC
GGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCACCCTCCTGGTTCTGCCCTGTCCCATTCCACCCCA
CCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCTTACGGTCGGTCTCCAGTGACTGAAGCATTCCCC
ACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGAGAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCT
CGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTACCTCCAAAATCCCCTTTTTGTTCTTCCTGGACC
TGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTGTATCCTGGCTCTCAGCTCATGGGGAAGCCACAT
AGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCTGATTCCTCAAGTTTTCTGCTTAGTGGCACTGAC
ATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTGGCCGTGGGCAGGCCCTAACTCACTGTCGCTTTG
GAGTTGAGGTGTCTTTTTTTTTTCTTTCTTTAGTTCCTGTATTCTAAACATTAGTAAAAATAAATGTTTTTACACAGAGCCCTCTGCTGG
ATGGTTTATCTCCTGCCTTTCTCCATTAAGAAGGCCATTTCATCCTAAGATTTCCATGATGGTGGTTTTTTTTTTTAATGTTTTGAAATA
CAGCTTTTTTCCCCCCAAATTAAAATTTTTTTGTGGAACCCCAATATGTAAAGCGAATATAAAATTGGTTATTTTGTTTTGTTACATAAA

>3108_3108_6_AHNAK-DPF2_AHNAK_chr11_62259204_ENST00000257247_DPF2_chr11_65116321_ENST00000528416_length(amino acids)=196AA_BP=
MWCVQNHFRAAGAEDFTGPGLARLGRAVPLAVQLQAHRVVPHGVQQLGHLTRLQVVKVDGGTHNLVPLLDHPSAGRRGVLRHLLHKDAVV
PLGDGQPVGATTLPVGQQQLPGCLLLLHLCRIPLRSECLARSPPLLPLFPSVSLVGNLGHNLRAQPQGTAIAGARPKAAVLRLLAATSPV

--------------------------------------------------------------
>3108_3108_7_AHNAK-DPF2_AHNAK_chr11_62302475_ENST00000530124_DPF2_chr11_65116321_ENST00000252268_length(transcript)=1734nt_BP=351nt
TCATTCCAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGCTGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAG
AGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCCCTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGT
GCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCCAGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCAC
CGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCCGTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGGACCAGTTG
CTCTTCTGTGATGACTGCGATCGTGGCTACCACATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCAC
CTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCCATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATC
TAAGGCTGTTTCTCTCCTCCACTTCATATTTCATACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGG
TTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTGAGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACA
CTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTCTCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATC
ACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGTGGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCT
GTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGGGAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATA
GCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGCGGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCAC
CCTCCTGGTTCTGCCCTGTCCCATTCCACCCCACCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCT
TACGGTCGGTCTCCAGTGACTGAAGCATTCCCCACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGA
GAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCTCGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTA
CCTCCAAAATCCCCTTTTTGTTCTTCCTGGACCTGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTG
TATCCTGGCTCTCAGCTCATGGGGAAGCCACATAGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCT
GATTCCTCAAGTTTTCTGCTTAGTGGCACTGACATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTG
GCCGTGGGCAGGCCCTAACTCACTGTCGCTTTGGAGTTGAGGTGTCTTTTTTTTTTCTTTCTTTAGTTCCTGTATTCTAAACATTAGTAA

>3108_3108_7_AHNAK-DPF2_AHNAK_chr11_62302475_ENST00000530124_DPF2_chr11_65116321_ENST00000252268_length(amino acids)=188AA_BP=0
MKWRRETALDMSGSRWVATSRGVLVLVDGSFLFQQVQTQVAAPTSFRGLRHGRGETVHVVATIAVITEEQLVQNHFRAAGAEDFTGPGLA
RLGRAVPLAVQLQAHRVVPHGVQQLGHLTRLQVVKVDGGTHNLVPLLDHPSAGRRGVLRHLLHKDAVVPLGDGQPVGATTLPVGQQQLPG

--------------------------------------------------------------
>3108_3108_8_AHNAK-DPF2_AHNAK_chr11_62302475_ENST00000530124_DPF2_chr11_65116321_ENST00000415073_length(transcript)=1939nt_BP=351nt
TCATTCCAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGCTGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAG
AGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCCCTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGT
GCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCCAGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCAC
CGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCCGTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGGACCAGTTG
CTCTTCTGTGATGACTGCGATCGTGGCTACCACATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCAC
CTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCCATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATC
TAAGGCTGTTTCTCTCCTCCACTTCATATTTCATACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGG
TTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTGAGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACA
CTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTCTCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATC
ACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGTGGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCT
GTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGGGAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATA
GCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGCGGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCAC
CCTCCTGGTTCTGCCCTGTCCCATTCCACCCCACCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCT
TACGGTCGGTCTCCAGTGACTGAAGCATTCCCCACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGA
GAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCTCGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTA
CCTCCAAAATCCCCTTTTTGTTCTTCCTGGACCTGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTG
TATCCTGGCTCTCAGCTCATGGGGAAGCCACATAGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCT
GATTCCTCAAGTTTTCTGCTTAGTGGCACTGACATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTG
GCCGTGGGCAGGCCCTAACTCACTGTCGCTTTGGAGTTGAGGTGTCTTTTTTTTTTCTTTCTTTAGTTCCTGTATTCTAAACATTAGTAA
AAATAAATGTTTTTACACAGAGCCCTCTGCTGGATGGTTTATCTCCTGCCTTTCTCCATTAAGAAGGCCATTTCATCCTAAGATTTCCAT
GATGGTGGTTTTTTTTTTTAATGTTTTGAAATACAGCTTTTTTCCCCCCAAATTAAAATTTTTTTGTGGAACCCCAATATGTAAAGCGAA

>3108_3108_8_AHNAK-DPF2_AHNAK_chr11_62302475_ENST00000530124_DPF2_chr11_65116321_ENST00000415073_length(amino acids)=189AA_BP=0
MKWRRETALDMSGSRWVATSRGVLVLVDGSFLFQQVQTQVAAPTSFRGLRHGRGETVHVVATIAVITEEQLVQNHFRAAGAEDFTGPGLA
RLGRAVPLAVQLQAHRVVPHGVQQLGHLTRLQVVKVDGGTHNLVPLLDHPSAGRRGVLRHLLHKDAVVPLGDGQPVGATTLPVGQQQLPG

--------------------------------------------------------------
>3108_3108_9_AHNAK-DPF2_AHNAK_chr11_62302475_ENST00000530124_DPF2_chr11_65116321_ENST00000528416_length(transcript)=2000nt_BP=351nt
TCATTCCAGATGGAGAAGGAGGAGACAACCCGGGAGCTGCTGCTGCCCAACTGGCAGGGTAGTGGCTCCCACGGGCTGACCATCGCCCAG
AGGGACGACGGCGTCTTTGTGCAGGAGGTGACGCAGAACTCCCCTGCGGCCCGCACTGGGGTGGTCAAGGAGGGGGACCAGATTGTGGGT
GCCACCATCTACTTTGACAACCTGCAGTCGGGTGAGGTGACCCAGCTGCTGAACACCATGGGGCACCACACGGTGGGCCTGAAGCTGCAC
CGCAAGGGGGACCGCTCTCCCGAGCCTGGCCAGACCTGGACCCGTGAAGTCTTCAGCTCCTGCAGCTCTGAAGTGGTTCTGGACCAGTTG
CTCTTCTGTGATGACTGCGATCGTGGCTACCACATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGAAGGAAGTTGGAGCTGCCAC
CTGTGTCTGGACCTGTTGAAAGAGAAAGCTTCCATCTACCAGAACCAGAACTCCTCTTGATGTGGCCACCCACCTGCTCCCCGACATATC
TAAGGCTGTTTCTCTCCTCCACTTCATATTTCATACCCATCTTTCCCTTCTTCCTCCTCTCCTTCACAAATCCAGAGAACCTTGGGGTGG
TTGTGCCAGCCTGCCTTTGGCAGCTGCAAGCTGAGGTGGCAGCTCTGACCACCTCTGGCCCCAGGCCCTCAGGGAGAAAGGAGCAACACA
CTGCCCCTAGGCGTGCGTGTGGCCCAGTTTCTCTCTGCTCTCCATTAAGTGCATTCACTCTGCTTGCCTTGGGCCCAGCCCCTGGTGATC
ACAGGGTTCAAACAGTGTCCTCCTAGAAAGAGTGGGAGAGCAGCTCACTTCTCTGTGTTCTGCCTCCCCTCTGGTCTCCAGAGTTTTCCT
GTCCTCTAGAGGCAAGCCAGGCCAGGGAGCTGGGAGCGAGCAAGCTGAGGCCACGTCCACAAGGAGCTTTTCATGCCCCTGTGCCGCATA
GCCTCACCTCTTTCCTCCAGAGTGGCTCTCTGCGGCCCTGTGTTCCTGCTACAGAGTGTTCTTTTCTGGAGTCAGGATGTTCTCGGTCAC
CCTCCTGGTTCTGCCCTGTCCCATTCCACCCCACCCCAGGGGGAACAGTAGCTTCACCTTGTTATTCCCATTGCTCTCCTGGCTCACTCT
TACGGTCGGTCTCCAGTGACTGAAGCATTCCCCACCCTTGGAATTTCTCATCTTCTGCCTCCCTTCCTACTCCTTTTGGTTTTGTGGGGA
GAGGGGAAGGATCAGGGGGCCAGGCCAGCAGCTCGGGGGCCACAAGGAGATGGATAATGTGCCTGTTTTTTAACACAACAAAAAAGCCTA
CCTCCAAAATCCCCTTTTTGTTCTTCCTGGACCTGGGCATTCAGCCTCCTGCTCTTAACTGAATTGGGAGCCTCTGCCACCTGCCCCGTG
TATCCTGGCTCTCAGCTCATGGGGAAGCCACATAGACATCCCTTTCTTCCCTTGCACGCTCGCTAGCAGCTGGTAAGGTCTTCACACCCT
GATTCCTCAAGTTTTCTGCTTAGTGGCACTGACATTAAGTAGTGGGGGGACAGTCCATGCCAGGACACCCTGGAGTAGCCTTCCCCCTTG
GCCGTGGGCAGGCCCTAACTCACTGTCGCTTTGGAGTTGAGGTGTCTTTTTTTTTTCTTTCTTTAGTTCCTGTATTCTAAACATTAGTAA
AAATAAATGTTTTTACACAGAGCCCTCTGCTGGATGGTTTATCTCCTGCCTTTCTCCATTAAGAAGGCCATTTCATCCTAAGATTTCCAT
GATGGTGGTTTTTTTTTTTAATGTTTTGAAATACAGCTTTTTTCCCCCCAAATTAAAATTTTTTTGTGGAACCCCAATATGTAAAGCGAA
TATAAAATTGGTTATTTTGTTTTGTTACATAAATTCAAGTTTATAACAATTCTTTGTTATAAAGAACAATGAAGCTGTTTTGATCAATAC

>3108_3108_9_AHNAK-DPF2_AHNAK_chr11_62302475_ENST00000530124_DPF2_chr11_65116321_ENST00000528416_length(amino acids)=166AA_BP=106
MEKEETTRELLLPNWQGSGSHGLTIAQRDDGVFVQEVTQNSPAARTGVVKEGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLKLHRKG

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Fusion Gene PPI Analysis for AHNAK-DPF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AHNAK-DPF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AHNAK-DPF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource