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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOXK1-SDK1 (FusionGDB2 ID:31090)

Fusion Gene Summary for FOXK1-SDK1

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXK1-SDK1
Fusion gene ID: 31090
HgeneTgene
Gene symbol

FOXK1

SDK1

Gene ID

221937

221935

Gene nameforkhead box K1sidekick cell adhesion molecule 1
SynonymsFOXK1L-
Cytomap

7p22.1

7p22.2

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein K1MNFmyocyte nuclear factorprotein sidekick-1sidekick homolog 1, cell adhesion molecule
Modification date2020031320200320
UniProtAcc

P85037

.
Ensembl transtripts involved in fusion geneENST00000328914, ENST00000446823, 
ENST00000466611, ENST00000389531, 
ENST00000404826, 
Fusion gene scores* DoF score6 X 4 X 5=12021 X 21 X 9=3969
# samples 723
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3969*10)=-4.10906979605546
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXK1 [Title/Abstract] AND SDK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOXK1(4722499)-SDK1(4247731), # samples:2
FOXK1(4722499)-SDK1(3861082), # samples:2
SDK1(3861215)-FOXK1(4794089), # samples:2
Anticipated loss of major functional domain due to fusion event.FOXK1-SDK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FOXK1-SDK1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SDK1-FOXK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SDK1-FOXK1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXK1

GO:0001678

cellular glucose homeostasis

29861159|30700909

HgeneFOXK1

GO:0010507

negative regulation of autophagy

25402684

HgeneFOXK1

GO:0010906

regulation of glucose metabolic process

29861159|30700909

HgeneFOXK1

GO:0042594

response to starvation

25402684

HgeneFOXK1

GO:0045892

negative regulation of transcription, DNA-templated

17670796|25402684

HgeneFOXK1

GO:0045893

positive regulation of transcription, DNA-templated

29861159|30700909

HgeneFOXK1

GO:0061621

canonical glycolysis

30700909


check buttonFusion gene breakpoints across FOXK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SDK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12L-01AFOXK1chr7

4722499

+SDK1chr7

4247731

+
ChimerDB4PRADTCGA-CH-5751-01AFOXK1chr7

4722499

+SDK1chr7

3861082

+
ChimerDB4PRADTCGA-CH-5751FOXK1chr7

4722499

+SDK1chr7

3861082

+


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Fusion Gene ORF analysis for FOXK1-SDK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000328914ENST00000466611FOXK1chr7

4722499

+SDK1chr7

4247731

+
5CDS-intronENST00000328914ENST00000466611FOXK1chr7

4722499

+SDK1chr7

3861082

+
Frame-shiftENST00000328914ENST00000389531FOXK1chr7

4722499

+SDK1chr7

4247731

+
Frame-shiftENST00000328914ENST00000404826FOXK1chr7

4722499

+SDK1chr7

4247731

+
In-frameENST00000328914ENST00000389531FOXK1chr7

4722499

+SDK1chr7

3861082

+
In-frameENST00000328914ENST00000404826FOXK1chr7

4722499

+SDK1chr7

3861082

+
intron-3CDSENST00000446823ENST00000389531FOXK1chr7

4722499

+SDK1chr7

4247731

+
intron-3CDSENST00000446823ENST00000389531FOXK1chr7

4722499

+SDK1chr7

3861082

+
intron-3CDSENST00000446823ENST00000404826FOXK1chr7

4722499

+SDK1chr7

4247731

+
intron-3CDSENST00000446823ENST00000404826FOXK1chr7

4722499

+SDK1chr7

3861082

+
intron-intronENST00000446823ENST00000466611FOXK1chr7

4722499

+SDK1chr7

4247731

+
intron-intronENST00000446823ENST00000466611FOXK1chr7

4722499

+SDK1chr7

3861082

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328914FOXK1chr74722499+ENST00000404826SDK1chr73861082+10105560064882162
ENST00000328914FOXK1chr74722499+ENST00000389531SDK1chr73861082+7453560064282142

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328914ENST00000404826FOXK1chr74722499+SDK1chr73861082+0.0008632140.99913687
ENST00000328914ENST00000389531FOXK1chr74722499+SDK1chr73861082+0.0019003890.9980996

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Fusion Genomic Features for FOXK1-SDK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FOXK1chr74722499+SDK1chr74247730+4.10E-060.99999595
FOXK1chr74722499+SDK1chr73861081+4.13E-101
FOXK1chr74722499+SDK1chr73861081+4.13E-101
FOXK1chr74722499+SDK1chr74247730+4.10E-060.99999595
FOXK1chr74722499+SDK1chr73861081+4.13E-101
FOXK1chr74722499+SDK1chr73861081+4.13E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FOXK1-SDK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:4722499/chr7:4247731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXK1

P85037

.
FUNCTION: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXK1chr7:4722499chr7:3861082ENST00000328914+1910_96186734.0Compositional biasAla-rich
HgeneFOXK1chr7:4722499chr7:3861082ENST00000328914+1935_62186734.0Compositional biasPro-rich
HgeneFOXK1chr7:4722499chr7:3861082ENST00000328914+19123_175186734.0DomainFHA
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451072_11712372214.0DomainFibronectin type-III 5
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451176_12742372214.0DomainFibronectin type-III 6
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451279_13762372214.0DomainFibronectin type-III 7
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451380_14742372214.0DomainFibronectin type-III 8
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451479_15762372214.0DomainFibronectin type-III 9
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451581_16992372214.0DomainFibronectin type-III 10
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451704_18002372214.0DomainFibronectin type-III 11
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451804_18992372214.0DomainFibronectin type-III 12
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263451902_20002372214.0DomainFibronectin type-III 13
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345293_3782372214.0DomainNote=Ig-like C2-type 3
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345386_4762372214.0DomainNote=Ig-like C2-type 4
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345480_5692372214.0DomainNote=Ig-like C2-type 5
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345574_6632372214.0DomainNote=Ig-like C2-type 6
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345670_7662372214.0DomainFibronectin type-III 1
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345771_8672372214.0DomainFibronectin type-III 2
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345872_9702372214.0DomainFibronectin type-III 3
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345974_10682372214.0DomainFibronectin type-III 4
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263452207_22132372214.0MotifPDZ-binding
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263452031_22132372214.0Topological domainCytoplasmic
TgeneSDK1chr7:4722499chr7:3861082ENST000004048263452010_20302372214.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXK1chr7:4722499chr7:3861082ENST00000446823+11210_960571.0Compositional biasAla-rich
HgeneFOXK1chr7:4722499chr7:3861082ENST00000446823+11235_620571.0Compositional biasPro-rich
HgeneFOXK1chr7:4722499chr7:3861082ENST00000328914+19305_400186734.0DNA bindingFork-head
HgeneFOXK1chr7:4722499chr7:3861082ENST00000446823+112305_4000571.0DNA bindingFork-head
HgeneFOXK1chr7:4722499chr7:3861082ENST00000446823+112123_1750571.0DomainFHA
TgeneSDK1chr7:4722499chr7:3861082ENST0000040482634519_582372214.0Compositional biasNote=Pro-rich
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345104_1862372214.0DomainNote=Ig-like C2-type 1
TgeneSDK1chr7:4722499chr7:3861082ENST00000404826345191_2772372214.0DomainNote=Ig-like C2-type 2


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Fusion Gene Sequence for FOXK1-SDK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31090_31090_1_FOXK1-SDK1_FOXK1_chr7_4722499_ENST00000328914_SDK1_chr7_3861082_ENST00000389531_length(transcript)=7453nt_BP=560nt
ATGGCCGAAGTCGGCGAGGACAGCGGCGCCCGCGCCCTGCTCGCGCTGCGCTCGGCGCCCTGCAGCCCAGTGCTGTGCGCCGCAGCCGCC
GCCGCCGCCTTCCCCGCGGCCGCACCCCCGCCGGCCCCCGCGCAGCCCCAGCCTCCGCCCGGGCCGCCGCCGCCGCCGCCACCGCCGCTG
CCTCCGGGCGCGATCGCGGGCGCGGGCTCCTCCGGGGGCTCCTCCGGGGTATCCGGGGACTCCGCGGTCGCGGGCGCGGCGCCGGCCCTG
GTGGCCGCGGCGGCCGCCTCGGTACGGCAGAGCCCGGGGCCGGCGCTGGCGCGGCTGGAGGGCCGCGAGTTCGAGTTCCTCATGCGCCAG
CCCAGCGTCACCATCGGCCGCAACTCGTCGCAGGGCTCGGTGGACTTGAGCATGGGCCTGTCCAGCTTCATCTCGCGGCGCCACCTGCAG
CTCAGCTTCCAGGAGCCGCACTTCTACCTGCGCTGCCTCGGCAAGAACGGCGTCTTCGTGGACGGGGCCTTCCAGAGACGCGGCGCGCCC
GCCCTGCAGCTGCCCAAGCAAGCCATCACATTGGAGAATCAGCTGGTGATCCTCGCCACCACAACCAGTGATGCCGGGGCATACTACGTG
CAGGCCGTGAATGAGAAAAATGGAGAAAACAAGACAAGCCCATTCATTCATTTGAGCATAGCAAGAGATGTTGGCACACCTGAAACCATG
GCCCCAACCATTGTGGTTCCCCCGGGCAACAGAAGTGTGGTGGCTGGATCCAGTGAGACCACCTTGGAATGTATAGCCAGTGCCAGGCCT
GTGGAGGACCTGAGTGTGACCTGGAAGAGGAATGGAGTGAGAATCACCAGTGGCCTCCACAGCTTTGGAAGACGCCTCACCATCAGCAAC
CCGACGTCCGCGGACACCGGGCCATACGTCTGCGAGGCGGCGCTGCCGGGGAGCGCTTTTGAACCGGCCAGGGCGACGGCCTTTCTTTTC
ATCATAGAGCCACCATATTTTACTGCTGAGCCCGAGAGTCGGATTTCAGCTGAAGTAGAAGAAACTGTGGACATCGGATGTCAAGCCATG
GGGGTCCCCCTTCCCACCCTCCAGTGGTACAAGGATGCCATCTCCATCAGCAGGCTCCAGAATCCTCGATACAAAGTGCTCGCCAGCGGA
GGCCTGCGCATCCAGAAGCTGCGTCCAGAGGACTCCGGAATCTTCCAGTGCTTCGCCAGCAATGAAGGAGGGGAGATCCAGACCCACACC
TACCTGGATGTAACCAATATCGCTCCAGTGTTCACCCAGCGGCCAGTGGACACCACAGTTACTGACGGGATGACAGCCATTCTAAGGTGT
GAGGTGTCCGGGGCTCCCAAACCCGCCATCACCTGGAAAAGAGAAAACCACATTCTGGCCAGTGGCTCTGTCCGGATTCCTAGGTTCATG
CTTCTTGAATCGGGGGGTCTACAGATCGCGCCCGTCTTCATCCAGGATGCCGGCAACTACACCTGCTATGCGGCCAACACAGAGGGCTCC
CTGAATGCATCGGCCACGCTCACTGTGTGGAATCGGACGTCCATCGTCCACCCTCCTGAGGACCACGTGGTGATTAAGGGGACCACGGCC
ACGCTGCACTGTGGTGCCACACATGACCCCCGGGTTTCACTCCGCTACGTTTGGAAGAAGGACAACGTGGCCCTGACTCCATCGAGCACG
TCTAGGATCGTGGTGGAGAAGGACGGGTCCCTTCTCATCAGCCAGACGTGGTCAGGCGACATCGGTGACTACAGCTGCGAGATTGTTTCT
GAAGGAGGGAATGACTCCAGGATGGCCCGGCTGGAAGTGATTGAACTGCCTCATTCACCTCAGAACCTCCTGGTCAGCCCTAATTCTTCC
CACAGCCACGCCGTGGTGCTCTCTTGGGTCCGGCCCTTTGATGGAAACAGTCCTATTCTTTATTACATCGTGGAGCTCTCTGAAAACAAC
TCTCCATGGAAGGTGCATCTGTCAAACGTTGGCCCTGAGATGACAGGCGTCACCGTGAGTGGCCTGACTCCGGCTCGTACCTATCAATTC
CGGGTGTGCGCGGTGAATGAAGTGGGCAGGGGCCAGTACAGCGCCGAGACAAGCAGGTTGATGCTACCTGAAGAACCACCCAGTGCTCCC
CCGAAAAATATAGTGGCCAGTGGGCGGACTAATCAGTCCATTATGGTCCAGTGGCAGCCACCCCCAGAAACAGAGCACAACGGGGTGTTG
CGTGGATACATCCTCAGGTACCGCCTGGCTGGCCTTCCCGGAGAGTACCAGCAGCGGAACATCACCAGCCCGGAGGTGAACTACTGCCTG
GTGACAGACCTGATCATCTGGACACAGTATGAGATACAGGTGGCGGCGTACAACGGGGCCGGTCTGGGCGTCTTCAGCAGGGCAGTGACC
GAGTACACCTTGCAGGGAGTGCCCACCGCGCCCCCGCAGAACGTGCAGACGGAAGCCGTGAACTCCACCACCATTCAGTTCCTGTGGAAC
CCTCCGCCTCAGCAGTTTATCAATGGCATCAACCAGGGATACAAGCTTCTGGCATGGCCGGCAGATGCCCCCGAGGCTGTCACTGTGGTC
ACTATTGCCCCAGATTTCCACGGAGTCCACCATGGACACATAACGAACCTGAAGAAGTTTACCGCCTACTTCACTTCCGTTCTGTGCTTC
ACCACCCCTGGGGACGGGCCTCCCAGCACACCTCAGCTGGTCTGGACTCAGGAAGACAAACCAGGAGCTGTGGGACATCTGAGTTTCACA
GAGATCTTGGACACATCTCTCAAGGTCAGCTGGCAGGAGCCCCTGGAGAAAAATGGCATCATTACTGGCTATCAGATCTCTTGGGAAGTG
TACGGCAGGAACGACTCTCGTCTCACGCACACCCTGAACAGCACGACGCACGAGTACAAGATCCAAGGCCTCTCATCTCTCACCACCTAC
ACCATCGACGTGGCCGCTGTGACTGCCGTGGGCACTGGCCTGGTGACTTCATCCACCATTTCTTCTGGAGTGCCCCCAGACCTTCCTGGT
GCCCCATCCAACCTGGTCATTTCCAACATCAGCCCTCGCTCCGCCACCCTTCAGTTCCGGCCAGGCTATGACGGGAAAACGTCCATCTCC
AGGTGGATTGTTGAGGGGCAGGTGGGAGCTATCGGCGACGAGGAGGAGTGGGTCACCCTCTATGAAGAGGAGAATGAGCCTGATGCCCAG
ATGCTGGAGATCCCAAACCTCACACCCTACACTCACTACAGATTTCGAATGAAGCAAGTGAACATTGTTGGGCCGAGCCCCTACAGTCCG
TCTTCCCGGGTCATCCAGACCCTGCAGGCCCCACCCGACGTGGCTCCAACCAGCGTCACGGTCCGTACTGCCAGTGAGACCAGCCTGCGG
CTTCGCTGGGTGCCCCTGCCGGATTCTCAGTACAACGGGAACCCCGAGTCCGTGGGCTACAGGATTAAGTACTGGCGCTCAGACCTCCAG
TCCTCAGCAGTGGCCCAAGTCGTCAGTGACCGGCTGGAGAGAGAATTCACCATCGAGGAGCTGGAGGAGTGGATGGAATACGAGCTGCAG
ATGCAGGCCTTCAACGCCGTCGGGGCTGGGCCGTGGAGCGAGGTGGTGCGGGGCCGGACGCGGGAGTCAGTTCCTTCAGCCGCCCCTGAG
AACGTGTCAGCCGAGGCTGTCAGCTCGACCCAGATTTTACTGACATGGACATCCGTGCCGGAACAGGACCAGAATGGGCTCATACTGGGC
TACAAGATCCTGTTCCGGGCCAAAGACCTGGATCCCGAGCCCAGGAGCCACATCGTGCGAGGGAACCACACGCAGTCGGCCCTGCTGGCA
GGCCTGCGCAAGTTCGTGCTCTACGAGCTCCAGGTGCTGGCGTTCACCCGCATCGGGAACGGGGTCCCCAGCACGCCCCTCATCCTGGAG
CGCACCAAAGACGATGCCCCAGGCCCACCAGTGAGGCTCGTGTTCCCCGAAGTGAGACTCACCTCCGTGCGGATAGTGTGGCAACCTCCG
GAGGAGCCCAACGGCATCATCCTGGGGTACCAGATTGCCTACCGCCTGGCCAGCAGCAGCCCCCACACCTTCACCACCGTGGAGGTCGGC
GCCACAGTGAGGCAGTTCACAGCCACCGACCTGGCCCCGGAGTCCGCATACATCTTCAGGCTGTCCGCCAAGACGAGGCAGGGCTGGGGG
GAGCCACTGGAGGCCACCGTCATCACCACCGAGAAGAGAGAGCGGCCGGCACCCCCCAGAGAGCTCCTGGTGCCCCAGGCAGAAGTGACC
GCACGCAGCCTCCGGCTCCAGTGGGTCCCGGGCAGCGACGGGGCCTCCCCCATCCGGTACTTCACCATGCAGGTGCGAGAGCTGCCTCGG
GGTGAGTGGCAGACCTACTCCTCGTCCATCAGCCATGAGGCGACAGCATGCGTCGTTGACAGACTGAGGCCCTTCACCTCCTACAAGCTG
CGCCTGAAAGCCACCAACGACATTGGGGACAGTGACTTCAGTTCAGAGACAGAGGCGGTGACCACGCTGCAGGATGTTCCAGGAGAGCCC
CCGGGATCTGTCTCAGCGACGCCACACACCACGTCCTCTGTCCTGATACAGTGGCAGCCTCCGAGGGACGAAAGCCTGAATGGCCTTCTT
CAGGGATACAGGATCTACTACAGGGAGCTGGAGTATGAAGCCGGGTCAGGCACTGAGGCCAAGACGCTCAAAAACCCTATAGCTTTACAT
GCTGAGCTCACAGATTTAAAGAAGTACCGGCGCTATGAAGTAATAATGACCGCCTATAACATCATCGGCGAGAGCCCAGCCAGCGCGCCC
GTGGAGGTCTTTGTCGGCGAGGCTGCCCCGGCCATGGCCCCGCAGAACGTGCAGGTGACCCCACTCACGGCCAGCCAGCTGGAGGTCACG
TGGGACCCACCACCCCCGGAGAGCCAGAATGGGAACATCCAAGGCTACAAGATTTACTACTGGGAGGCAGACAGCCAGAACGAAACGGAG
AAAATGAAGGTCCTCTTCCTCCCCGAGCCCGTGGTGAGGCTGAAGAACCTGACCAGCCATACCAAGTACCTGGTCAGCATATCAGCCTTC
AACGCCGCCGGAGATGGACCTAAGAGTGACCCCCAGCAGGGGCGCACCCACCAGGCCGCCCCTGGGGCCCCCAGCTTTCTGGCGTTCTCA
GAAATAACCTCCACCACGCTCAACGTGTCCTGGGGCGAGCCTGCGGCGGCCAACGGCATCCTGCAGGGCTATCGGGTGGTGTACGAGCCC
TTGGCCCCTGTACAAGGGGTGAGCAAGGTGGTGACCGTGGAAGTGAGAGGGAACTGGCAGCGCTGGCTGAAGGTGCGGGACCTCACCAAG
GGAGTGACCTATTTCTTCCGTGTCCAAGCGCGGACCATCACCTACGGGCCCGAGCTCCAAGCCAATATCACAGCCGGGCCAGCCGAGGGA
TCCCCGGGCTCGCCTAGAGATGTCCTGGTCACCAAGTCCGCCTCTGAACTGACGCTGCAGTGGACTGAGGGACACTCTGGCGACACACCT
ACCACGGGCTATGTGATCGAGGCCCGGCCCTCAGATGAAGGCTTATGGGACATGTTTGTGAAGGACATCCCGCGGAGCGCCACATCCTAC
ACCCTCAGCCTGGATAAGCTCCGGCAAGGAGTGACTTACGAGTTCCGGGTGGTGGCTGTGAATGAGGCGGGCTACGGGGAGCCCAGCAAC
CCCTCCACGGCTGTGTCAGCTCAAGTGGAAGCCCCATTCTACGAGGAGTGGTGGTTCCTCCTGGTGATGGCTCTGTCCAGCCTGATCGTC
ATCCTGCTGGTGGTGTTCGCCCTCGTCCTGCACGGGCAGAATAAGAAGTATAAGAACTGCAGCACAGGAAAGGGGATCTCCACCATGGAG
GAGTCTGTGACCCTGGACAACGGAGGATTTGCTGCCCTGGAGCTCAGCAGCCGCCACCTCAATGTCAAGAGCACCTTCTCCAAGAAGAAC
GGGACCAGGTCCCCACCCCGGCCTAGCCCCGGCGGCCTGCACTACTCAGACGAGGACATCTGCAACAAGTACAACGGCGCCGTGCTGACC
GAGAGCGTGAGCCTCAAGGAGAAGTCGGCAGATGCATCAGAATCTGAGGCCACGGACTCTGACTACGAGGACGCGCTGCCCAAGCACTCC
TTCGTGAACCACTACATGAGCGACCCCACCTACTACAACTCATGGAAGCGCAGGGCCCAGGGCCGCGCACCTGCGCCGCACAGGTACGAG
GCGGTGGCGGGCTCCGAGGCGGGCGCGCAGCTGCACCCGGTCATCACCACGCAGAGCGCGGGCGGCGTCTACACCCCCGCTGGCCCCGGC
GCGCGAACTCCGCTCACCGGCTTCTCCTCCTTCGTGTGAGCAAAGCGCCGCGCCTCCCTCAGGGCGGAACGGAGGCAACTTTCCGGAGTC
TATTTTTGTTAAGACAATCAACTCCAATAACTGAGCTGAAGTTTTTGTTTAAAAAGAAAAAAATCTGATAAGTGATGATTTTACCTACTT
GTGGACACTAGATTTCAATTAGGAAGGTTTTTTTAAACGGCTTTTTGTAACTTCGCTGCAGGAAGCAGGTTTGTTTCTTTTTCTTTTCTT
TTTAAGAGAAGGTGTATTTCACTGGTGCAATGGCTTGGCACCTCCGGGGCCTGGGAGGACCTCAGACCTCCCCAGCCCTGGGTTTCTCCG
TCTTCAAGACCAACTAGGAAGGGTCAAGCGGGGAGAGGGAGTGGAGGGTCAGGTGAGATCTCAGAGCTGCCCCGGCCGGCCCCCGTCTCT
TTCTACCTCCTCTTCCAGAGAACCAGCGGCTCACACCCTTCTCAACGCAGGACATCCTCGGCGGCTCCTGGGGTTTGAAGAGCAAACGTT
TTTCCCTGGGCTCAGTGCGTTTTGTCCCAACTTCATCTGTTTCTGAAATGTTCTCACTTGGCAGTGTCTAGTCAAGGAGTCGGCTTTCAG
GTTCCTGACGGCCAGGCAGGGATGCTAAGGTGTGGCTCAGCCGTCACTGTCTGTGTCACTGCAGTGGTGCGGTCCTCAGGCTTTTCTGCC
TGTCTTTCCCCCTTCCTTCTCACCTGACAGCGAGGGAGAGGGAAGCCTCTTAGGGCTGGAAGCCACCACGCTGGCCCTCTCCTTCCCCGA
ACACAGCACACGGTCAACTCCGCGGGACACGAGGACACGGGACGGCGTCTCCAGAATTGCTTGTTACGTAGGAAGCGTGCATTGTTAACC
AGAGTATTTTTAAAATCTTTTTATCTTTTTTTAAACTATGTCACATGAAATGAATGCGTCTTTGCTGTCTCCAGGTGCCTTTTTATTAAT

>31090_31090_1_FOXK1-SDK1_FOXK1_chr7_4722499_ENST00000328914_SDK1_chr7_3861082_ENST00000389531_length(amino acids)=2142AA_BP=187
MAEVGEDSGARALLALRSAPCSPVLCAAAAAAAFPAAAPPPAPAQPQPPPGPPPPPPPPLPPGAIAGAGSSGGSSGVSGDSAVAGAAPAL
VAAAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAP
ALQLPKQAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARP
VEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAM
GVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRC
EVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTA
TLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSS
HSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAP
PKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVT
EYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCF
TTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY
TIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQ
MLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQ
SSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILG
YKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPP
EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVT
ARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP
PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTDLKKYRRYEVIMTAYNIIGESPASAP
VEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAF
NAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTK
GVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSY
TLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTME
ESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHS

--------------------------------------------------------------
>31090_31090_2_FOXK1-SDK1_FOXK1_chr7_4722499_ENST00000328914_SDK1_chr7_3861082_ENST00000404826_length(transcript)=10105nt_BP=560nt
ATGGCCGAAGTCGGCGAGGACAGCGGCGCCCGCGCCCTGCTCGCGCTGCGCTCGGCGCCCTGCAGCCCAGTGCTGTGCGCCGCAGCCGCC
GCCGCCGCCTTCCCCGCGGCCGCACCCCCGCCGGCCCCCGCGCAGCCCCAGCCTCCGCCCGGGCCGCCGCCGCCGCCGCCACCGCCGCTG
CCTCCGGGCGCGATCGCGGGCGCGGGCTCCTCCGGGGGCTCCTCCGGGGTATCCGGGGACTCCGCGGTCGCGGGCGCGGCGCCGGCCCTG
GTGGCCGCGGCGGCCGCCTCGGTACGGCAGAGCCCGGGGCCGGCGCTGGCGCGGCTGGAGGGCCGCGAGTTCGAGTTCCTCATGCGCCAG
CCCAGCGTCACCATCGGCCGCAACTCGTCGCAGGGCTCGGTGGACTTGAGCATGGGCCTGTCCAGCTTCATCTCGCGGCGCCACCTGCAG
CTCAGCTTCCAGGAGCCGCACTTCTACCTGCGCTGCCTCGGCAAGAACGGCGTCTTCGTGGACGGGGCCTTCCAGAGACGCGGCGCGCCC
GCCCTGCAGCTGCCCAAGCAAGCCATCACATTGGAGAATCAGCTGGTGATCCTCGCCACCACAACCAGTGATGCCGGGGCATACTACGTG
CAGGCCGTGAATGAGAAAAATGGAGAAAACAAGACAAGCCCATTCATTCATTTGAGCATAGCAAGAGATGTTGGCACACCTGAAACCATG
GCCCCAACCATTGTGGTTCCCCCGGGCAACAGAAGTGTGGTGGCTGGATCCAGTGAGACCACCTTGGAATGTATAGCCAGTGCCAGGCCT
GTGGAGGACCTGAGTGTGACCTGGAAGAGGAATGGAGTGAGAATCACCAGTGGCCTCCACAGCTTTGGAAGACGCCTCACCATCAGCAAC
CCGACGTCCGCGGACACCGGGCCATACGTCTGCGAGGCGGCGCTGCCGGGGAGCGCTTTTGAACCGGCCAGGGCGACGGCCTTTCTTTTC
ATCATAGAGCCACCATATTTTACTGCTGAGCCCGAGAGTCGGATTTCAGCTGAAGTAGAAGAAACTGTGGACATCGGATGTCAAGCCATG
GGGGTCCCCCTTCCCACCCTCCAGTGGTACAAGGATGCCATCTCCATCAGCAGGCTCCAGAATCCTCGATACAAAGTGCTCGCCAGCGGA
GGCCTGCGCATCCAGAAGCTGCGTCCAGAGGACTCCGGAATCTTCCAGTGCTTCGCCAGCAATGAAGGAGGGGAGATCCAGACCCACACC
TACCTGGATGTAACCAATATCGCTCCAGTGTTCACCCAGCGGCCAGTGGACACCACAGTTACTGACGGGATGACAGCCATTCTAAGGTGT
GAGGTGTCCGGGGCTCCCAAACCCGCCATCACCTGGAAAAGAGAAAACCACATTCTGGCCAGTGGCTCTGTCCGGATTCCTAGGTTCATG
CTTCTTGAATCGGGGGGTCTACAGATCGCGCCCGTCTTCATCCAGGATGCCGGCAACTACACCTGCTATGCGGCCAACACAGAGGGCTCC
CTGAATGCATCGGCCACGCTCACTGTGTGGAATCGGACGTCCATCGTCCACCCTCCTGAGGACCACGTGGTGATTAAGGGGACCACGGCC
ACGCTGCACTGTGGTGCCACACATGACCCCCGGGTTTCACTCCGCTACGTTTGGAAGAAGGACAACGTGGCCCTGACTCCATCGAGCACG
TCTAGGATCGTGGTGGAGAAGGACGGGTCCCTTCTCATCAGCCAGACGTGGTCAGGCGACATCGGTGACTACAGCTGCGAGATTGTTTCT
GAAGGAGGGAATGACTCCAGGATGGCCCGGCTGGAAGTGATTGAACTGCCTCATTCACCTCAGAACCTCCTGGTCAGCCCTAATTCTTCC
CACAGCCACGCCGTGGTGCTCTCTTGGGTCCGGCCCTTTGATGGAAACAGTCCTATTCTTTATTACATCGTGGAGCTCTCTGAAAACAAC
TCTCCATGGAAGGTGCATCTGTCAAACGTTGGCCCTGAGATGACAGGCGTCACCGTGAGTGGCCTGACTCCGGCTCGTACCTATCAATTC
CGGGTGTGCGCGGTGAATGAAGTGGGCAGGGGCCAGTACAGCGCCGAGACAAGCAGGTTGATGCTACCTGAAGAACCACCCAGTGCTCCC
CCGAAAAATATAGTGGCCAGTGGGCGGACTAATCAGTCCATTATGGTCCAGTGGCAGCCACCCCCAGAAACAGAGCACAACGGGGTGTTG
CGTGGATACATCCTCAGGTACCGCCTGGCTGGCCTTCCCGGAGAGTACCAGCAGCGGAACATCACCAGCCCGGAGGTGAACTACTGCCTG
GTGACAGACCTGATCATCTGGACACAGTATGAGATACAGGTGGCGGCGTACAACGGGGCCGGTCTGGGCGTCTTCAGCAGGGCAGTGACC
GAGTACACCTTGCAGGGAGTGCCCACCGCGCCCCCGCAGAACGTGCAGACGGAAGCCGTGAACTCCACCACCATTCAGTTCCTGTGGAAC
CCTCCGCCTCAGCAGTTTATCAATGGCATCAACCAGGGATACAAGCTTCTGGCATGGCCGGCAGATGCCCCCGAGGCTGTCACTGTGGTC
ACTATTGCCCCAGATTTCCACGGAGTCCACCATGGACACATAACGAACCTGAAGAAGTTTACCGCCTACTTCACTTCCGTTCTGTGCTTC
ACCACCCCTGGGGACGGGCCTCCCAGCACACCTCAGCTGGTCTGGACTCAGGAAGACAAACCAGGAGCTGTGGGACATCTGAGTTTCACA
GAGATCTTGGACACATCTCTCAAGGTCAGCTGGCAGGAGCCCCTGGAGAAAAATGGCATCATTACTGGCTATCAGATCTCTTGGGAAGTG
TACGGCAGGAACGACTCTCGTCTCACGCACACCCTGAACAGCACGACGCACGAGTACAAGATCCAAGGCCTCTCATCTCTCACCACCTAC
ACCATCGACGTGGCCGCTGTGACTGCCGTGGGCACTGGCCTGGTGACTTCATCCACCATTTCTTCTGGAGTGCCCCCAGACCTTCCTGGT
GCCCCATCCAACCTGGTCATTTCCAACATCAGCCCTCGCTCCGCCACCCTTCAGTTCCGGCCAGGCTATGACGGGAAAACGTCCATCTCC
AGGTGGATTGTTGAGGGGCAGGTGGGAGCTATCGGCGACGAGGAGGAGTGGGTCACCCTCTATGAAGAGGAGAATGAGCCTGATGCCCAG
ATGCTGGAGATCCCAAACCTCACACCCTACACTCACTACAGATTTCGAATGAAGCAAGTGAACATTGTTGGGCCGAGCCCCTACAGTCCG
TCTTCCCGGGTCATCCAGACCCTGCAGGCCCCACCCGACGTGGCTCCAACCAGCGTCACGGTCCGTACTGCCAGTGAGACCAGCCTGCGG
CTTCGCTGGGTGCCCCTGCCGGATTCTCAGTACAACGGGAACCCCGAGTCCGTGGGCTACAGGATTAAGTACTGGCGCTCAGACCTCCAG
TCCTCAGCAGTGGCCCAAGTCGTCAGTGACCGGCTGGAGAGAGAATTCACCATCGAGGAGCTGGAGGAGTGGATGGAATACGAGCTGCAG
ATGCAGGCCTTCAACGCCGTCGGGGCTGGGCCGTGGAGCGAGGTGGTGCGGGGCCGGACGCGGGAGTCAGTTCCTTCAGCCGCCCCTGAG
AACGTGTCAGCCGAGGCTGTCAGCTCGACCCAGATTTTACTGACATGGACATCCGTGCCGGAACAGGACCAGAATGGGCTCATACTGGGC
TACAAGATCCTGTTCCGGGCCAAAGACCTGGATCCCGAGCCCAGGAGCCACATCGTGCGAGGGAACCACACGCAGTCGGCCCTGCTGGCA
GGCCTGCGCAAGTTCGTGCTCTACGAGCTCCAGGTGCTGGCGTTCACCCGCATCGGGAACGGGGTCCCCAGCACGCCCCTCATCCTGGAG
CGCACCAAAGACGATGCCCCAGGCCCACCAGTGAGGCTCGTGTTCCCCGAAGTGAGACTCACCTCCGTGCGGATAGTGTGGCAACCTCCG
GAGGAGCCCAACGGCATCATCCTGGGGTACCAGATTGCCTACCGCCTGGCCAGCAGCAGCCCCCACACCTTCACCACCGTGGAGGTCGGC
GCCACAGTGAGGCAGTTCACAGCCACCGACCTGGCCCCGGAGTCCGCATACATCTTCAGGCTGTCCGCCAAGACGAGGCAGGGCTGGGGG
GAGCCACTGGAGGCCACCGTCATCACCACCGAGAAGAGAGAGCGGCCGGCACCCCCCAGAGAGCTCCTGGTGCCCCAGGCAGAAGTGACC
GCACGCAGCCTCCGGCTCCAGTGGGTCCCGGGCAGCGACGGGGCCTCCCCCATCCGGTACTTCACCATGCAGGTGCGAGAGCTGCCTCGG
GGTGAGTGGCAGACCTACTCCTCGTCCATCAGCCATGAGGCGACAGCATGCGTCGTTGACAGACTGAGGCCCTTCACCTCCTACAAGCTG
CGCCTGAAAGCCACCAACGACATTGGGGACAGTGACTTCAGTTCAGAGACAGAGGCGGTGACCACGCTGCAGGATGTTCCAGGAGAGCCC
CCGGGATCTGTCTCAGCGACGCCACACACCACGTCCTCTGTCCTGATACAGTGGCAGCCTCCGAGGGACGAAAGCCTGAATGGCCTTCTT
CAGGGATACAGGATCTACTACAGGGAGCTGGAGTATGAAGCCGGGTCAGGCACTGAGGCCAAGACGCTCAAAAACCCTATAGCTTTACAT
GCTGAGCTCACAGCCCAAAGCAGCTTCAAGACGGTGAACAGCAGCTCCACATCGACGATGTGTGAACTAACACATTTAAAGAAGTACCGG
CGCTATGAAGTAATAATGACCGCCTATAACATCATCGGCGAGAGCCCAGCCAGCGCGCCCGTGGAGGTCTTTGTCGGCGAGGCTGCCCCG
GCCATGGCCCCGCAGAACGTGCAGGTGACCCCACTCACGGCCAGCCAGCTGGAGGTCACGTGGGACCCACCACCCCCGGAGAGCCAGAAT
GGGAACATCCAAGGCTACAAGATTTACTACTGGGAGGCAGACAGCCAGAACGAAACGGAGAAAATGAAGGTCCTCTTCCTCCCCGAGCCC
GTGGTGAGGCTGAAGAACCTGACCAGCCATACCAAGTACCTGGTCAGCATATCAGCCTTCAACGCCGCCGGAGATGGACCTAAGAGTGAC
CCCCAGCAGGGGCGCACCCACCAGGCCGCCCCTGGGGCCCCCAGCTTTCTGGCGTTCTCAGAAATAACCTCCACCACGCTCAACGTGTCC
TGGGGCGAGCCTGCGGCGGCCAACGGCATCCTGCAGGGCTATCGGGTGGTGTACGAGCCCTTGGCCCCTGTACAAGGGGTGAGCAAGGTG
GTGACCGTGGAAGTGAGAGGGAACTGGCAGCGCTGGCTGAAGGTGCGGGACCTCACCAAGGGAGTGACCTATTTCTTCCGTGTCCAAGCG
CGGACCATCACCTACGGGCCCGAGCTCCAAGCCAATATCACAGCCGGGCCAGCCGAGGGATCCCCGGGCTCGCCTAGAGATGTCCTGGTC
ACCAAGTCCGCCTCTGAACTGACGCTGCAGTGGACTGAGGGACACTCTGGCGACACACCTACCACGGGCTATGTGATCGAGGCCCGGCCC
TCAGATGAAGGCTTATGGGACATGTTTGTGAAGGACATCCCGCGGAGCGCCACATCCTACACCCTCAGCCTGGATAAGCTCCGGCAAGGA
GTGACTTACGAGTTCCGGGTGGTGGCTGTGAATGAGGCGGGCTACGGGGAGCCCAGCAACCCCTCCACGGCTGTGTCAGCTCAAGTGGAA
GCCCCATTCTACGAGGAGTGGTGGTTCCTCCTGGTGATGGCTCTGTCCAGCCTGATCGTCATCCTGCTGGTGGTGTTCGCCCTCGTCCTG
CACGGGCAGAATAAGAAGTATAAGAACTGCAGCACAGGAAAGGGGATCTCCACCATGGAGGAGTCTGTGACCCTGGACAACGGAGGATTT
GCTGCCCTGGAGCTCAGCAGCCGCCACCTCAATGTCAAGAGCACCTTCTCCAAGAAGAACGGGACCAGGTCCCCACCCCGGCCTAGCCCC
GGCGGCCTGCACTACTCAGACGAGGACATCTGCAACAAGTACAACGGCGCCGTGCTGACCGAGAGCGTGAGCCTCAAGGAGAAGTCGGCA
GATGCATCAGAATCTGAGGCCACGGACTCTGACTACGAGGACGCGCTGCCCAAGCACTCCTTCGTGAACCACTACATGAGCGACCCCACC
TACTACAACTCATGGAAGCGCAGGGCCCAGGGCCGCGCACCTGCGCCGCACAGGTACGAGGCGGTGGCGGGCTCCGAGGCGGGCGCGCAG
CTGCACCCGGTCATCACCACGCAGAGCGCGGGCGGCGTCTACACCCCCGCTGGCCCCGGCGCGCGAACTCCGCTCACCGGCTTCTCCTCC
TTCGTGTGAGCAAAGCGCCGCGCCTCCCTCAGGGCGGAACGGAGGCAACTTTCCGGAGTCTATTTTTGTTAAGACAATCAACTCCAATAA
CTGAGCTGAAGTTTTTGTTTAAAAAGAAAAAAATCTGATAAGTGATGATTTTACCTACTTGTGGACACTAGATTTCAATTAGGAAGGTTT
TTTTAAACGGCTTTTTGTAACTTCGCTGCAGGAAGCAGGTTTGTTTCTTTTTCTTTTCTTTTTAAGAGAAGGTGTATTTCACTGGTGCAA
TGGCTTGGCACCTCCGGGGCCTGGGAGGACCTCAGACCTCCCCAGCCCTGGGTTTCTCCGTCTTCAAGACCAACTAGGAAGGGTCAAGCG
GGGAGAGGGAGTGGAGGGTCAGGTGAGATCTCAGAGCTGCCCCGGCCGGCCCCCGTCTCTTTCTACCTCCTCTTCCAGAGAACCAGCGGC
TCACACCCTTCTCAACGCAGGACATCCTCGGCGGCTCCTGGGGTTTGAAGAGCAAACGTTTTTCCCTGGGCTCAGTGCGTTTTGTCCCAA
CTTCATCTGTTTCTGAAATGTTCTCACTTGGCAGTGTCTAGTCAAGGAGTCGGCTTTCAGGTTCCTGACGGCCAGGCAGGGATGCTAAGG
TGTGGCTCAGCCGTCACTGTCTGTGTCACTGCAGTGGTGCGGTCCTCAGGCTTTTCTGCCTGTCTTTCCCCCTTCCTTCTCACCTGACAG
CGAGGGAGAGGGAAGCCTCTTAGGGCTGGAAGCCACCACGCTGGCCCTCTCCTTCCCCGAACACAGCACACGGTCAACTCCGCGGGACAC
GAGGACACGGGACGGCGTCTCCAGAATTGCTTGTTACGTAGGAAGCGTGCATTGTTAACCAGAGTATTTTTAAAATCTTTTTATCTTTTT
TTAAACTATGTCACATGAAATGAATGCGTCTTTGCTGTCTCCAGGTGCCTTTTTATTAATTGTTCAGCTTTGTACATGGGAAAGATGAAA
AGCAACAGTGTCTGCAAATAAAGCAAAACAGCTCTGAGAACACACGCTCCCGACTCGCCTCGTGCACACCAGGCCGTCCCCTCCCTCTGT
CCTGGCTTCTGCTGGCTGCTCGCAGCAGCCACCGCTTCTCCACCACTGGCGCTGCTGCTGCCCCCTCTCCCAGTCCGAGGCCAGCTTTTA
GCCTTAACAGGTTTTTTGGAAATGTTTCTTTTTTTTATTTAAAATTGTCATTGTTTGGTTTAAATTTTTCAGCTAGATGAAAAGAGTATG
AACTACTTTGGAAAACTTAACAGCTCAGAGATGGCCATGCCTCCAGCCCCTCACGTCATCTTTGCAACAGACGACTGGGCTGCCATGGTC
CACCCCTCAGCCCGGGTCCCGGGTCTGGATGGAACGGGAGCACTGCTGGTGCCCACTGGCGTGTGTGCCCCGGGTCCCTGTAAGTGCCCC
CTCACCAGCAGCAGCGTGACACACACAAGACTCAAGACCACCCTGTCAGTGCCCCCCAGTGCACGGCAAACGGGCAGGTGCCGTTCCCCC
AGTGACCTGAGGGTAGGGGACAACTGAGCAGTATCTGACCAGTGCCACCCAGGAGCCAGTCTCCTGGCCACATGCAGAAAGTGTGGCCCC
TGCTTACCTAGATGTTTTGTGCACCTCCATGGGCAGAGGGTGTGGATATTGCCTGGATTCTGTGCTGTCAGCGTTGCTGAGTATGGCCCC
AGGAGACCAAGGAGAGTTTTGTATAGGCTGGAAAACCCCTTTTCAGTCTTTCCAAAATTAGAGGGTATGGCAAGTTTCCTTTTTTCTCTC
CTCCCTTCCTTCCCCTCCTTCCTTTCCTTTACCCCTCCTTTCCTTCCTTCCTCCCTTCCTCTCTTCTTTCCTCCCTCCCTCCCTCCTTCC
CTCCCTTCCTTCCTCTCTTTCCTCCTTCCTTCCCTCCCTTCTTTCCCTCCCTCCCTTCCTCTCTCCCCTATTCCTTCTTCCTTTTCTCCT
CCTTTTTCTGAGTGGAGGGGGAAATATTCTAAACCAAAAATCCTAGATGCTCTGCCCAAAGCCACTTCTGCATGAGAATCGCAACCCACA
GTTCCCCGGATGAGACTCACCACAGTGGACAGTGCCACCTCCTTCCCCTCGGCCCCGGAGAGGGCGAAGTGGGCGGGAAGCCAGGATGTG
AGCACTGGAATTTCTTGGAAGAGAAGCGATAAATGGAGACCATGGCCAGCGCTGCTTTCTGTGCACTCTGATGACTGCTCTCTGCAGCCA
TGAGGATGTGGCTTTACATGCCAGGGAGAGTGTTGAGACGTCTTAGGTTGAGGATGAGCAGATTCGAGATATGTTTGTTGCTCTCGGGTT
TTCGATACAACATCATGACACTTCTGTTTCAAGCTCATGTTTTCCGTCTCCCCTCCACTCTTAGTAAACCTTGATCTGTACGGAGCGGCC
TGTCCGAGGCTACGCCGGCCTCCTGGCTGCTGCTGGACTGTGCTTAGGACAGCGCCCATGCCTCGGAGGGACTCTGTCCCATGAGAACCA
CCTGTGCAAAGGAACAGAGCTGGATGTTTCCAGGTAGATTTTGGCCTCCCAGAGCAATGCGGCATTTGAGAAGCAACAGTTCCTAACTCC
TTATCTTCAGGGAAGGAAAAGAAAATCACAGCCTAGGAAGATGGAGGTTGGATTTTAATCTCGGTTTTAAAAAGAGGACAAACAAAATGT
CTCTAAGCCAGGCTAGATGGAATGTGCTCCCGCTCTCTCCTGCCGTGCTGAAAGTCATGCCTTGCGGATGCCTCATGACAGCAGTGGCTG
AGTCTCCCCACCCACCCCCAACGTGGCTCATTTCAGATTGCTTCGGCCCCACCCTGCAAGGATGTGGTCACGGAGTGGCCAGGAGGCTCC
GTCTGAGCCACAGGGATGGGTGTGCAGAGCTCCCTCCTCCTGGGGTGCCAGGGCAGAGATTCCAGGCAGGTGAGCCCAGAGAGAGCTGCC
AGGCCACACCCCCTCGGCCTCCTGCACGGCCACCTTCTGGGTGAATCGGTCCAGCCCAAGCCCCTCTCCCCAGCCTCGCCTTCAGCCTCT
CTCCCAGCCTGCTTTTATAAGGCGCACTTCACTCAATGCTGTAGCCAAAAAACGAGGGGCCCCAGGGAGAGGGGACCCAGATGGCCACAC
ACGGAACGCGCCTCCACAGCCCCGGGAGGTGGCTCACTCTGTACAGGTCTTCGGAGGCCGTGTTTGTATCTAACTGTGACTGGGCTGAAG
CATGATGTTTGCCTAATGGTTCGTAGCATGGTTTTTATTTCTTACGCATTCTTGGCACACAGTGTAGCTATCCTCCTGACGAGCAACCCG
TCTGCGTACCTAAGTGTGGCTCCCCGTGGGTCAGCGTCCTGGTAGCATGGATCCAGTCTGAAAGGTGAGGACAACGTGGAAACTCATGAG
CTGAGCCTGCCCGCTGGGACACGTCTCCTTCCCGCGTCACCTTCTGGTTTAGGGAGCCGTCAGGTCCCTAAACGTTCCCTACAACTTTTT
CTGAAATTGTGCAGAAAAACAGATCTCATTAAAAGAAAAAAAGAAACAACTTGTAGGAAGACAGAGAGGTGCTATGGGTACAATTTTTAA

>31090_31090_2_FOXK1-SDK1_FOXK1_chr7_4722499_ENST00000328914_SDK1_chr7_3861082_ENST00000404826_length(amino acids)=2162AA_BP=187
MAEVGEDSGARALLALRSAPCSPVLCAAAAAAAFPAAAPPPAPAQPQPPPGPPPPPPPPLPPGAIAGAGSSGGSSGVSGDSAVAGAAPAL
VAAAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAP
ALQLPKQAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARP
VEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAM
GVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRC
EVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTA
TLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSS
HSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAP
PKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVT
EYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCF
TTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY
TIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQ
MLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQ
SSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILG
YKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPP
EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVT
ARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP
PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYR
RYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEP
VVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKV
VTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARP
SDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVL
HGQNKKYKNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSA
DASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSS

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Fusion Gene PPI Analysis for FOXK1-SDK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneFOXK1chr7:4722499chr7:3861082ENST00000328914+192_40186.66666666666666734.0SIN3A and SIN3B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFOXK1chr7:4722499chr7:3861082ENST00000446823+1122_400571.0SIN3A and SIN3B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOXK1-SDK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOXK1-SDK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource