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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FRAS1-ANXA3 (FusionGDB2 ID:31274)

Fusion Gene Summary for FRAS1-ANXA3

check button Fusion gene summary
Fusion gene informationFusion gene name: FRAS1-ANXA3
Fusion gene ID: 31274
HgeneTgene
Gene symbol

FRAS1

ANXA3

Gene ID

80144

306

Gene nameFraser extracellular matrix complex subunit 1annexin A3
SynonymsFRASRS1ANX3
Cytomap

4q21.21

4q21.21

Type of geneprotein-codingprotein-coding
Descriptionextracellular matrix protein FRAS1Fraser syndrome 1annexin A335-alpha calcimedinAnnexin III (lipocortin III)PAP-IIIannexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)annexin-3calcimedin 35-alphainositol 1,2-cyclic p
Modification date2020031320200313
UniProtAcc

Q86XX4

P12429

Ensembl transtripts involved in fusion geneENST00000264895, ENST00000264899, 
ENST00000325942, 		ENST00000503570, 
ENST00000512884, ENST00000264908, 
Fusion gene scores* DoF score12 X 8 X 8=7684 X 3 X 4=48
# samples 134
** MAII scorelog2(13/768*10)=-2.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRAS1 [Title/Abstract] AND ANXA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRAS1(78987170)-ANXA3(79494334), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANXA3

GO:0006909

phagocytosis

9497492

TgeneANXA3

GO:0010595

positive regulation of endothelial cell migration

16236264

TgeneANXA3

GO:0042742

defense response to bacterium

9497492

TgeneANXA3

GO:0043312

neutrophil degranulation

9550422

TgeneANXA3

GO:0045766

positive regulation of angiogenesis

16236264

TgeneANXA3

GO:0051091

positive regulation of DNA-binding transcription factor activity

16236264


check buttonFusion gene breakpoints across FRAS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANXA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-75-6214-01AFRAS1chr4

78987170

+ANXA3chr4

79494334

+


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Fusion Gene ORF analysis for FRAS1-ANXA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264895ENST00000503570FRAS1chr4

78987170

+ANXA3chr4

79494334

+
5CDS-5UTRENST00000264899ENST00000503570FRAS1chr4

78987170

+ANXA3chr4

79494334

+
5CDS-5UTRENST00000325942ENST00000503570FRAS1chr4

78987170

+ANXA3chr4

79494334

+
5CDS-intronENST00000264895ENST00000512884FRAS1chr4

78987170

+ANXA3chr4

79494334

+
5CDS-intronENST00000264899ENST00000512884FRAS1chr4

78987170

+ANXA3chr4

79494334

+
5CDS-intronENST00000325942ENST00000512884FRAS1chr4

78987170

+ANXA3chr4

79494334

+
In-frameENST00000264895ENST00000264908FRAS1chr4

78987170

+ANXA3chr4

79494334

+
In-frameENST00000264899ENST00000264908FRAS1chr4

78987170

+ANXA3chr4

79494334

+
In-frameENST00000325942ENST00000264908FRAS1chr4

78987170

+ANXA3chr4

79494334

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264899FRAS1chr478987170+ENST00000264908ANXA3chr479494334+18115484071504365
ENST00000325942FRAS1chr478987170+ENST00000264908ANXA3chr479494334+18115484071504365
ENST00000264895FRAS1chr478987170+ENST00000264908ANXA3chr479494334+18115484071504365

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264899ENST00000264908FRAS1chr478987170+ANXA3chr479494334+0.0005710590.9994289
ENST00000325942ENST00000264908FRAS1chr478987170+ANXA3chr479494334+0.0005710590.9994289
ENST00000264895ENST00000264908FRAS1chr478987170+ANXA3chr479494334+0.0005710590.9994289

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Fusion Genomic Features for FRAS1-ANXA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FRAS1chr478987170+ANXA3chr479494333+0.0002120720.999788
FRAS1chr478987170+ANXA3chr479494333+0.0002120720.999788

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FRAS1-ANXA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:78987170/chr4:79494334)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRAS1

Q86XX4

ANXA3

P12429

FUNCTION: Involved in extracellular matrix organization (By similarity). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (By similarity). Involved in brain organization and function (By similarity). {ECO:0000250|UniProtKB:Q80T14}.FUNCTION: Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANXA3chr4:78987170chr4:79494334ENST00000264908113173_2455324.0RepeatAnnexin 3
TgeneANXA3chr4:78987170chr4:79494334ENST0000026490811318_895324.0RepeatAnnexin 1
TgeneANXA3chr4:78987170chr4:79494334ENST00000264908113249_3205324.0RepeatAnnexin 4
TgeneANXA3chr4:78987170chr4:79494334ENST0000026490811390_1615324.0RepeatAnnexin 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274157_217364013.0DomainVWFC 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274219_279364013.0DomainVWFC 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742543_2646364013.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742659_2770364013.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742784_2890364013.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+27427_88364013.0DomainVWFC 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274283_343364013.0DomainVWFC 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742905_3007364013.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2743025_3129364013.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274347_417364013.0DomainVWFC 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+27493_153364013.0DomainVWFC 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219157_21736738.0DomainVWFC 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219219_27936738.0DomainVWFC 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192543_264636738.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192659_277036738.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192784_289036738.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+21927_8836738.0DomainVWFC 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219283_34336738.0DomainVWFC 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192905_300736738.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2193025_312936738.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219347_41736738.0DomainVWFC 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+21993_15336738.0DomainVWFC 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242157_217361977.0DomainVWFC 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242219_279361977.0DomainVWFC 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422543_2646361977.0DomainNote=Calx-beta 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422659_2770361977.0DomainNote=Calx-beta 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422784_2890361977.0DomainNote=Calx-beta 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+24227_88361977.0DomainVWFC 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242283_343361977.0DomainVWFC 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422905_3007361977.0DomainNote=Calx-beta 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2423025_3129361977.0DomainNote=Calx-beta 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242347_417361977.0DomainVWFC 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+24293_153361977.0DomainVWFC 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741046_1089364013.0RepeatNote=FU 14
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741102_1197364013.0RepeatCSPG 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741217_1308364013.0RepeatCSPG 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741329_1438364013.0RepeatCSPG 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741463_1559364013.0RepeatCSPG 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741595_1689364013.0RepeatCSPG 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741710_1810364013.0RepeatCSPG 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741833_1936364013.0RepeatCSPG 7
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2741957_2057364013.0RepeatCSPG 8
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742078_2177364013.0RepeatCSPG 9
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742199_2291364013.0RepeatCSPG 10
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742311_2404364013.0RepeatCSPG 11
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2742439_2536364013.0RepeatCSPG 12
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274409_460364013.0RepeatNote=FU 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274462_505364013.0RepeatNote=FU 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274507_553364013.0RepeatNote=FU 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274555_599364013.0RepeatNote=FU 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274602_647364013.0RepeatNote=FU 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274649_705364013.0RepeatNote=FU 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274708_753364013.0RepeatNote=FU 7
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274755_800364013.0RepeatNote=FU 8
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274803_852364013.0RepeatNote=FU 9
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274854_900364013.0RepeatNote=FU 10
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274903_948364013.0RepeatNote=FU 11
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274952_997364013.0RepeatNote=FU 12
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+274999_1042364013.0RepeatNote=FU 13
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191046_108936738.0RepeatNote=FU 14
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191102_119736738.0RepeatCSPG 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191217_130836738.0RepeatCSPG 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191329_143836738.0RepeatCSPG 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191463_155936738.0RepeatCSPG 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191595_168936738.0RepeatCSPG 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191710_181036738.0RepeatCSPG 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191833_193636738.0RepeatCSPG 7
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2191957_205736738.0RepeatCSPG 8
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192078_217736738.0RepeatCSPG 9
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192199_229136738.0RepeatCSPG 10
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192311_240436738.0RepeatCSPG 11
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2192439_253636738.0RepeatCSPG 12
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219409_46036738.0RepeatNote=FU 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219462_50536738.0RepeatNote=FU 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219507_55336738.0RepeatNote=FU 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219555_59936738.0RepeatNote=FU 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219602_64736738.0RepeatNote=FU 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219649_70536738.0RepeatNote=FU 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219708_75336738.0RepeatNote=FU 7
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219755_80036738.0RepeatNote=FU 8
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219803_85236738.0RepeatNote=FU 9
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219854_90036738.0RepeatNote=FU 10
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219903_94836738.0RepeatNote=FU 11
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219952_99736738.0RepeatNote=FU 12
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+219999_104236738.0RepeatNote=FU 13
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421046_1089361977.0RepeatNote=FU 14
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421102_1197361977.0RepeatCSPG 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421217_1308361977.0RepeatCSPG 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421329_1438361977.0RepeatCSPG 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421463_1559361977.0RepeatCSPG 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421595_1689361977.0RepeatCSPG 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421710_1810361977.0RepeatCSPG 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421833_1936361977.0RepeatCSPG 7
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2421957_2057361977.0RepeatCSPG 8
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422078_2177361977.0RepeatCSPG 9
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422199_2291361977.0RepeatCSPG 10
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422311_2404361977.0RepeatCSPG 11
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2422439_2536361977.0RepeatCSPG 12
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242409_460361977.0RepeatNote=FU 1
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242462_505361977.0RepeatNote=FU 2
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242507_553361977.0RepeatNote=FU 3
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242555_599361977.0RepeatNote=FU 4
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242602_647361977.0RepeatNote=FU 5
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242649_705361977.0RepeatNote=FU 6
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242708_753361977.0RepeatNote=FU 7
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242755_800361977.0RepeatNote=FU 8
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242803_852361977.0RepeatNote=FU 9
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242854_900361977.0RepeatNote=FU 10
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242903_948361977.0RepeatNote=FU 11
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242952_997361977.0RepeatNote=FU 12
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+242999_1042361977.0RepeatNote=FU 13
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+27427_3901364013.0Topological domainExtracellular
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2743923_4008364013.0Topological domainCytoplasmic
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+21927_390136738.0Topological domainExtracellular
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2193923_400836738.0Topological domainCytoplasmic
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+24227_3901361977.0Topological domainExtracellular
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2423923_4008361977.0Topological domainCytoplasmic
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264895+2743902_3922364013.0TransmembraneHelical
HgeneFRAS1chr4:78987170chr4:79494334ENST00000264899+2193902_392236738.0TransmembraneHelical
HgeneFRAS1chr4:78987170chr4:79494334ENST00000325942+2423902_3922361977.0TransmembraneHelical


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Fusion Gene Sequence for FRAS1-ANXA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31274_31274_1_FRAS1-ANXA3_FRAS1_chr4_78987170_ENST00000264895_ANXA3_chr4_79494334_ENST00000264908_length(transcript)=1811nt_BP=548nt
AACTTTAAAAAGCTGCTTCGGACAAACCAGAGCCAGGATTTCCACTGTCGGGGACCCGGGATCGGAAGGGTCTAGCCCGAGGGAAATGCT
GGAAGATCCCATCGGCCAGTGACCAGCAACTTTCCGGCGAGATTTTGACGCGGAGAACTGTGCTCTGCCTCCTCTTATTCTCCCAAAGCT
CACGTTGGCGTCCTGCCTTGCGGGGGAACTCGGCGCGCTCTCTGCCTGAGCAGCGAGTGAATTGAACCCCAGCCCGCTCCGGCGCCTCCG
GGCTGATGAGTGTCGCTCTCCGCCCGTCCATCTCTTTTTCCCGGAGGTAAAGGCCCGCGGTCCCCCACCTTCAGTGCGCCCGGGTTCCAA
GCGCCGGAGCCAGCGTTTTGGCGGAGCCGCTTCTTGGATGCTGAAGGCTGGGCTCCTCCATCGTGGGTGCCGAGGCGGCGATGGGTGTCC
TCAAAGTGTGGCTCGGGCTGGCCCTAGCGTTGGCGGAATTTGCAGTATTGCCTCATCATTCCGAAGGTGCTTGTGTCTATCAGGATTCCT
TGTTGGCGGTTGGACACCGAGGAACAGTAAGAGATTATCCAGACTTTAGCCCATCAGTGGATGCTGAAGCTATTCAGAAAGCAATCAGAG
GAATTGGAACTGATGAGAAAATGCTCATCAGCATTCTGACTGAGAGGTCAAATGCACAGCGGCAGCTGATTGTTAAGGAATATCAAGCAG
CATATGGAAAGGAGCTGAAAGATGACTTGAAGGGTGATCTCTCTGGCCACTTTGAGCATCTCATGGTGGCCCTAGTGACTCCACCAGCAG
TCTTTGATGCAAAGCAGCTAAAGAAATCCATGAAGGGCGCGGGAACAAACGAAGATGCCTTGATTGAAATCTTAACTACCAGGACAAGCA
GGCAAATGAAGGATATCTCTCAAGCCTATTATACAGTATACAAGAAGAGTCTTGGAGATGACATTAGTTCCGAAACATCTGGTGACTTCC
GGAAAGCTCTGTTGACTTTGGCAGATGGCAGAAGAGATGAAAGTCTGAAAGTGGATGAGCATCTGGCCAAACAAGATGCCCAGATTCTCT
ATAAAGCTGGTGAGAACAGATGGGGCACGGATGAAGACAAATTCACTGAGATCCTGTGTTTAAGGAGCTTTCCTCAATTAAAACTAACAT
TTGATGAATACAGAAATATCAGCCAAAAGGACATTGTGGACAGCATAAAAGGAGAATTATCTGGGCATTTTGAAGACTTACTGTTGGCCA
TAGTTAATTGTGTGAGGAACACGCCGGCCTTTTTAGCCGAAAGACTGCATCGAGCCTTGAAGGGTATTGGAACTGATGAGTTTACTCTGA
ACCGAATAATGGTGTCCAGATCAGAAATTGACCTTTTGGACATTCGAACAGAGTTCAAGAAGCATTATGGCTATTCCCTATATTCAGCAA
TTAAATCGGATACTTCTGGAGACTATGAAATCACACTCTTAAAAATCTGTGGTGGAGATGACTGAACCAAGAAGATAATCTCCAAAGGTC
CACGATGGGCTTTCCCAACAGCTCCACCTTACTTCTTCTCATACTATTTAAGAGAACAAGCAAATATAAACAGCAACTTGTGTTCCTAAC
AGGAATTTTCATTGTTCTATAACAACAACAACAAAAGCGATTATTATTTTAGAGCATCTCATTTATAATGTAGCAGCTCATAAATGAAAT
TGAAAATGGTATTAAAGATCTGCAACTACTATCCAACTTATATTTCTGCTTTCAAAGTTAAGAATCTTTATAGTTCTACTCCATTAAATA

>31274_31274_1_FRAS1-ANXA3_FRAS1_chr4_78987170_ENST00000264895_ANXA3_chr4_79494334_ENST00000264908_length(amino acids)=365AA_BP=1
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLAVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTER
SNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKK
SLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSI
KGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKI

--------------------------------------------------------------
>31274_31274_2_FRAS1-ANXA3_FRAS1_chr4_78987170_ENST00000264899_ANXA3_chr4_79494334_ENST00000264908_length(transcript)=1811nt_BP=548nt
AACTTTAAAAAGCTGCTTCGGACAAACCAGAGCCAGGATTTCCACTGTCGGGGACCCGGGATCGGAAGGGTCTAGCCCGAGGGAAATGCT
GGAAGATCCCATCGGCCAGTGACCAGCAACTTTCCGGCGAGATTTTGACGCGGAGAACTGTGCTCTGCCTCCTCTTATTCTCCCAAAGCT
CACGTTGGCGTCCTGCCTTGCGGGGGAACTCGGCGCGCTCTCTGCCTGAGCAGCGAGTGAATTGAACCCCAGCCCGCTCCGGCGCCTCCG
GGCTGATGAGTGTCGCTCTCCGCCCGTCCATCTCTTTTTCCCGGAGGTAAAGGCCCGCGGTCCCCCACCTTCAGTGCGCCCGGGTTCCAA
GCGCCGGAGCCAGCGTTTTGGCGGAGCCGCTTCTTGGATGCTGAAGGCTGGGCTCCTCCATCGTGGGTGCCGAGGCGGCGATGGGTGTCC
TCAAAGTGTGGCTCGGGCTGGCCCTAGCGTTGGCGGAATTTGCAGTATTGCCTCATCATTCCGAAGGTGCTTGTGTCTATCAGGATTCCT
TGTTGGCGGTTGGACACCGAGGAACAGTAAGAGATTATCCAGACTTTAGCCCATCAGTGGATGCTGAAGCTATTCAGAAAGCAATCAGAG
GAATTGGAACTGATGAGAAAATGCTCATCAGCATTCTGACTGAGAGGTCAAATGCACAGCGGCAGCTGATTGTTAAGGAATATCAAGCAG
CATATGGAAAGGAGCTGAAAGATGACTTGAAGGGTGATCTCTCTGGCCACTTTGAGCATCTCATGGTGGCCCTAGTGACTCCACCAGCAG
TCTTTGATGCAAAGCAGCTAAAGAAATCCATGAAGGGCGCGGGAACAAACGAAGATGCCTTGATTGAAATCTTAACTACCAGGACAAGCA
GGCAAATGAAGGATATCTCTCAAGCCTATTATACAGTATACAAGAAGAGTCTTGGAGATGACATTAGTTCCGAAACATCTGGTGACTTCC
GGAAAGCTCTGTTGACTTTGGCAGATGGCAGAAGAGATGAAAGTCTGAAAGTGGATGAGCATCTGGCCAAACAAGATGCCCAGATTCTCT
ATAAAGCTGGTGAGAACAGATGGGGCACGGATGAAGACAAATTCACTGAGATCCTGTGTTTAAGGAGCTTTCCTCAATTAAAACTAACAT
TTGATGAATACAGAAATATCAGCCAAAAGGACATTGTGGACAGCATAAAAGGAGAATTATCTGGGCATTTTGAAGACTTACTGTTGGCCA
TAGTTAATTGTGTGAGGAACACGCCGGCCTTTTTAGCCGAAAGACTGCATCGAGCCTTGAAGGGTATTGGAACTGATGAGTTTACTCTGA
ACCGAATAATGGTGTCCAGATCAGAAATTGACCTTTTGGACATTCGAACAGAGTTCAAGAAGCATTATGGCTATTCCCTATATTCAGCAA
TTAAATCGGATACTTCTGGAGACTATGAAATCACACTCTTAAAAATCTGTGGTGGAGATGACTGAACCAAGAAGATAATCTCCAAAGGTC
CACGATGGGCTTTCCCAACAGCTCCACCTTACTTCTTCTCATACTATTTAAGAGAACAAGCAAATATAAACAGCAACTTGTGTTCCTAAC
AGGAATTTTCATTGTTCTATAACAACAACAACAAAAGCGATTATTATTTTAGAGCATCTCATTTATAATGTAGCAGCTCATAAATGAAAT
TGAAAATGGTATTAAAGATCTGCAACTACTATCCAACTTATATTTCTGCTTTCAAAGTTAAGAATCTTTATAGTTCTACTCCATTAAATA

>31274_31274_2_FRAS1-ANXA3_FRAS1_chr4_78987170_ENST00000264899_ANXA3_chr4_79494334_ENST00000264908_length(amino acids)=365AA_BP=1
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLAVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTER
SNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKK
SLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSI
KGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKI

--------------------------------------------------------------
>31274_31274_3_FRAS1-ANXA3_FRAS1_chr4_78987170_ENST00000325942_ANXA3_chr4_79494334_ENST00000264908_length(transcript)=1811nt_BP=548nt
AACTTTAAAAAGCTGCTTCGGACAAACCAGAGCCAGGATTTCCACTGTCGGGGACCCGGGATCGGAAGGGTCTAGCCCGAGGGAAATGCT
GGAAGATCCCATCGGCCAGTGACCAGCAACTTTCCGGCGAGATTTTGACGCGGAGAACTGTGCTCTGCCTCCTCTTATTCTCCCAAAGCT
CACGTTGGCGTCCTGCCTTGCGGGGGAACTCGGCGCGCTCTCTGCCTGAGCAGCGAGTGAATTGAACCCCAGCCCGCTCCGGCGCCTCCG
GGCTGATGAGTGTCGCTCTCCGCCCGTCCATCTCTTTTTCCCGGAGGTAAAGGCCCGCGGTCCCCCACCTTCAGTGCGCCCGGGTTCCAA
GCGCCGGAGCCAGCGTTTTGGCGGAGCCGCTTCTTGGATGCTGAAGGCTGGGCTCCTCCATCGTGGGTGCCGAGGCGGCGATGGGTGTCC
TCAAAGTGTGGCTCGGGCTGGCCCTAGCGTTGGCGGAATTTGCAGTATTGCCTCATCATTCCGAAGGTGCTTGTGTCTATCAGGATTCCT
TGTTGGCGGTTGGACACCGAGGAACAGTAAGAGATTATCCAGACTTTAGCCCATCAGTGGATGCTGAAGCTATTCAGAAAGCAATCAGAG
GAATTGGAACTGATGAGAAAATGCTCATCAGCATTCTGACTGAGAGGTCAAATGCACAGCGGCAGCTGATTGTTAAGGAATATCAAGCAG
CATATGGAAAGGAGCTGAAAGATGACTTGAAGGGTGATCTCTCTGGCCACTTTGAGCATCTCATGGTGGCCCTAGTGACTCCACCAGCAG
TCTTTGATGCAAAGCAGCTAAAGAAATCCATGAAGGGCGCGGGAACAAACGAAGATGCCTTGATTGAAATCTTAACTACCAGGACAAGCA
GGCAAATGAAGGATATCTCTCAAGCCTATTATACAGTATACAAGAAGAGTCTTGGAGATGACATTAGTTCCGAAACATCTGGTGACTTCC
GGAAAGCTCTGTTGACTTTGGCAGATGGCAGAAGAGATGAAAGTCTGAAAGTGGATGAGCATCTGGCCAAACAAGATGCCCAGATTCTCT
ATAAAGCTGGTGAGAACAGATGGGGCACGGATGAAGACAAATTCACTGAGATCCTGTGTTTAAGGAGCTTTCCTCAATTAAAACTAACAT
TTGATGAATACAGAAATATCAGCCAAAAGGACATTGTGGACAGCATAAAAGGAGAATTATCTGGGCATTTTGAAGACTTACTGTTGGCCA
TAGTTAATTGTGTGAGGAACACGCCGGCCTTTTTAGCCGAAAGACTGCATCGAGCCTTGAAGGGTATTGGAACTGATGAGTTTACTCTGA
ACCGAATAATGGTGTCCAGATCAGAAATTGACCTTTTGGACATTCGAACAGAGTTCAAGAAGCATTATGGCTATTCCCTATATTCAGCAA
TTAAATCGGATACTTCTGGAGACTATGAAATCACACTCTTAAAAATCTGTGGTGGAGATGACTGAACCAAGAAGATAATCTCCAAAGGTC
CACGATGGGCTTTCCCAACAGCTCCACCTTACTTCTTCTCATACTATTTAAGAGAACAAGCAAATATAAACAGCAACTTGTGTTCCTAAC
AGGAATTTTCATTGTTCTATAACAACAACAACAAAAGCGATTATTATTTTAGAGCATCTCATTTATAATGTAGCAGCTCATAAATGAAAT
TGAAAATGGTATTAAAGATCTGCAACTACTATCCAACTTATATTTCTGCTTTCAAAGTTAAGAATCTTTATAGTTCTACTCCATTAAATA

>31274_31274_3_FRAS1-ANXA3_FRAS1_chr4_78987170_ENST00000325942_ANXA3_chr4_79494334_ENST00000264908_length(amino acids)=365AA_BP=1
MGSSIVGAEAAMGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLAVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTER
SNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKK
SLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSI
KGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FRAS1-ANXA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FRAS1-ANXA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FRAS1-ANXA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource