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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FRMD4B-PPP2R3A (FusionGDB2 ID:31347)

Fusion Gene Summary for FRMD4B-PPP2R3A

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD4B-PPP2R3A
Fusion gene ID: 31347
HgeneTgene
Gene symbol

FRMD4B

PPP2R3A

Gene ID

23150

5523

Gene nameFERM domain containing 4Bprotein phosphatase 2 regulatory subunit B''alpha
Synonyms6030440G05Rik|GRSP1PPP2R3|PR130|PR72
Cytomap

3p14.1

3q22.2-q22.3

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 4BGRP1-binding protein GRSP1serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alphaPP2A subunit B isoforms B72/B130PP2A, subunit B, R3 isoformPR130/B''alpha1 subunitPR72/B''alpha2 subuitprotein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), al
Modification date2020031320200313
UniProtAcc

Q9Y2L6

.
Ensembl transtripts involved in fusion geneENST00000398540, ENST00000542259, 
ENST00000478263, ENST00000497757, 
ENST00000469270, ENST00000492624, 
ENST00000490467, ENST00000264977, 
ENST00000334546, 
Fusion gene scores* DoF score13 X 10 X 8=10408 X 6 X 5=240
# samples 149
** MAII scorelog2(14/1040*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRMD4B [Title/Abstract] AND PPP2R3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRMD4B(69271009)-PPP2R3A(135863885), # samples:2
Anticipated loss of major functional domain due to fusion event.FRMD4B-PPP2R3A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FRMD4B-PPP2R3A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FRMD4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2785-01AFRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+


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Fusion Gene ORF analysis for FRMD4B-PPP2R3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000398540ENST00000469270FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
5CDS-intronENST00000398540ENST00000492624FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
5CDS-intronENST00000542259ENST00000469270FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
5CDS-intronENST00000542259ENST00000492624FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
Frame-shiftENST00000398540ENST00000490467FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
Frame-shiftENST00000542259ENST00000264977FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
Frame-shiftENST00000542259ENST00000334546FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
In-frameENST00000398540ENST00000264977FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
In-frameENST00000398540ENST00000334546FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
In-frameENST00000542259ENST00000490467FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-3CDSENST00000478263ENST00000264977FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-3CDSENST00000478263ENST00000334546FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-3CDSENST00000478263ENST00000490467FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-3CDSENST00000497757ENST00000264977FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-3CDSENST00000497757ENST00000334546FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-3CDSENST00000497757ENST00000490467FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-intronENST00000478263ENST00000469270FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-intronENST00000478263ENST00000492624FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-intronENST00000497757ENST00000469270FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+
intron-intronENST00000497757ENST00000492624FRMD4Bchr3

69271009

-PPP2R3Achr3

135863885

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398540FRMD4Bchr369271009-ENST00000264977PPP2R3Achr3135863885+366481584938284
ENST00000398540FRMD4Bchr369271009-ENST00000334546PPP2R3Achr3135863885+121081584938284
ENST00000542259FRMD4Bchr369271009-ENST00000490467PPP2R3Achr3135863885+13631021111144377

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398540ENST00000264977FRMD4Bchr369271009-PPP2R3Achr3135863885+0.0005182090.99948186
ENST00000398540ENST00000334546FRMD4Bchr369271009-PPP2R3Achr3135863885+0.0020680880.99793196
ENST00000542259ENST00000490467FRMD4Bchr369271009-PPP2R3Achr3135863885+0.0041100830.99588996

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Fusion Genomic Features for FRMD4B-PPP2R3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FRMD4Bchr369271008-PPP2R3Achr3135863884+9.56E-050.9999044
FRMD4Bchr369271008-PPP2R3Achr3135863884+9.56E-050.9999044

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FRMD4B-PPP2R3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:69271009/chr3:135863885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRMD4B

Q9Y2L6

.
FUNCTION: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP2R3Achr3:69271009chr3:135863885ENST000003345461113985_996488530.0Calcium bindingOntology_term=ECO:0000255
TgenePPP2R3Achr3:69271009chr3:135863885ENST000004904671113985_996373415.0Calcium bindingOntology_term=ECO:0000255
TgenePPP2R3Achr3:69271009chr3:135863885ENST000003345461113670_695488530.0Compositional biasNote=Pro-rich
TgenePPP2R3Achr3:69271009chr3:135863885ENST000004904671113670_695373415.0Compositional biasNote=Pro-rich
TgenePPP2R3Achr3:69271009chr3:135863885ENST000003345461113758_793488530.0DomainEF-hand 1
TgenePPP2R3Achr3:69271009chr3:135863885ENST000003345461113972_1007488530.0DomainEF-hand 2
TgenePPP2R3Achr3:69271009chr3:135863885ENST000004904671113758_793373415.0DomainEF-hand 1
TgenePPP2R3Achr3:69271009chr3:135863885ENST000004904671113972_1007373415.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD4Bchr3:69271009chr3:135863885ENST00000398540-923417_4502431035.0Coiled coilOntology_term=ECO:0000255
HgeneFRMD4Bchr3:69271009chr3:135863885ENST00000398540-923531_5612431035.0Coiled coilOntology_term=ECO:0000255
HgeneFRMD4Bchr3:69271009chr3:135863885ENST00000398540-92359_3612431035.0DomainFERM
HgeneFRMD4Bchr3:69271009chr3:135863885ENST00000398540-923542_9712431035.0RegionNecessary for adherens junction and tight junction localization
TgenePPP2R3Achr3:69271009chr3:135863885ENST000002649771214985_99611091151.0Calcium bindingOntology_term=ECO:0000255
TgenePPP2R3Achr3:69271009chr3:135863885ENST000002649771214670_69511091151.0Compositional biasNote=Pro-rich
TgenePPP2R3Achr3:69271009chr3:135863885ENST000002649771214758_79311091151.0DomainEF-hand 1
TgenePPP2R3Achr3:69271009chr3:135863885ENST000002649771214972_100711091151.0DomainEF-hand 2


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Fusion Gene Sequence for FRMD4B-PPP2R3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31347_31347_1_FRMD4B-PPP2R3A_FRMD4B_chr3_69271009_ENST00000398540_PPP2R3A_chr3_135863885_ENST00000264977_length(transcript)=3664nt_BP=815nt
CGGGAGCCCAGGCGGGCAGGCCGCTGGGGTCGGGGCTGCACGTACGAGAGCCGGGACGCCCGGGTTCAGAGCGAAGGAGGAGGCATGGCT
TCGGTGTTCATGTGTGGCGTGGAGGACCTGCTGTTCAGCGGCAGCCGCTTCGTATGGAACTTGACCGTGTCCACGCTGCGGAGATGGTAC
ACGGAGAGGCTGCGGGCTTGCCACCAGGTGCTGCGGACGTGGTGCGGGCTGCAGGACGTGTACCAGATGACAGAAGGCAGGCACTGCCAG
GTGCACCTCCTGGATGATAGGAGACTGGAGCTGCTGGTTCAGCCCAAACTTCTAGCAAGAGAGTTGCTGGACCTAGTGGCTTCACATTTC
AACCTGAAAGAAAAGGAGTATTTTGGAATAACATTCATAGATGACACAGGTCAGCAGAACTGGCTGCAGTTAGATCACCGAGTTCTTGAC
CACGATTTGCCCAAGAAACCAGGCCCAACCATTTTGCACTTTGCTGTGAGGTTTTACATTGAGAGCATATCGTTTTTAAAGGATAAAACC
ACCGTGGAGCTGTTTTTCCTGAATGCAAAGGCCTGTGTGCACAAGGGGCAAATCGAAGTAGAGAGCGAAACCATCTTCAAGTTAGCAGCG
TTTATTTTACAGGAAGCCAAGGGAGATTATACCAGTGATGAAAATGCCAGGAAAGATTTAAAGACATTACCAGCCTTTCCAACCAAAACT
CTTCAGGAGCATCCATCCCTTGCCTACTGTGAGGACAGGGTAATTGAGCATTATTTGAAAATCAAAGGTCTCACTCGAGGTCAAGCTGTG
GTTCACTTTGAAGATTATGAAACAGATGAACCTGCCTCTCCCTCTGAATTTGGAAACAAAAGCAATAAAATATTAAGTGCAAGCCTTCCA
GAGAAATGTGGAAAGCTTCAATCAGTGGATGAAGAATAGCTGCCGGTGTCTACAATGAAACGAAGATGTGTATTTTAAATGTTTCTTTCT
TGTGAAGAGATGTTCTCGTTTGCATACTGCTTTTTAAAGACTTTGATTTCTCCAAGTGTGTATCATCTGCACTAGGAACTTTGTTTTTAA
GCAATAGGTCTGGATACACATTTAACTTAGGAGGCTCCTCCAATTTGCCTCAAACCTCTTACGGAGCTTCTCCTCAGAAGTGGTACCATC
GCCTTCCAAAGTCAGCACTCTACACTCTTGAATGTACCAAGGATCTCTTGGCGACAGTACCAAGCACGGTTCTCTACACAGGTGACTGAA
GTTGCCTCTGTGTTGGCTGGCATCCCTGAGTCCCCTCCGGGCTCCTATGGAGCCTAGAAGAAACCTTCACTTGCAGAAAACTTGAGTCAG
AAAATTCTGGAACTTGAAAAAGTAGTAAGGGCCTCCAGAATTGACTTAGCCCTAGTAATAAAAGCACTGCCAAAACATCTCAGAGACTTC
TTTTATGTATACTGGAGTTCAAAGATCTTTAACTTACCTGGCTTAATGTAATTTCACAGTTACCTGCCAAACTACTAGTCACTTTACATC
CTCAGGTATTGTAACCACTGGGCCTTCCAACTTTGCTGGCAAGCTCTGGTAACCTCCCTGACTGTGGATCTTATATAAAATCTCAAGATA
AAAAAACACTTCTTAAATGAAGTATAGAATTTGACTCATACTTGGAAAAAGCCCTTTTAACTTTTATCTTTTATTCATTGAACTATTGAA
TGATGTATTTAATATCCAAATTAGTTGATAACTGTTTTCACTTCCTATCAGAAGGCCTGCTTGAAGACATAAAGGAATAATGATACATTA
AAATTCTTACTAGATAGATATATTCCTTCCTCCCAGGAGTATTAGACTAGCTAATAGTAAAGGCCTCAACGTTATTCTTTACTTCATGTT
GAAAACAATTACTACAGATATTTCATCCACCTCAGTATTTATCAAGGAAATGGAAAATGATACAGCTATAAAAGAAAGCTGTTATTTACT
GTAGTTGTAGATGTATTCACTACAGAATCCTACATTTTTCAGCAGGCCACAGTCCAGCCAAATCCTATAATATCCTTGAAAAGAAACTAT
TAAAAAGGATAGACATTTCTGATGTAAGTAAAACCCCCAAGCAACTTAATATCCATCTGTCAGTCATCAACTTTTCCCCTAGATTTTTTT
TTTAACTAGTTCTGAAAGTGTCAAGAATAGCTTCCCTTTCCACCCTACCTAGGTTCCCTCCTTGCTGGCATAAAGGCCAAGCAGTGAAAT
GAACCTTGGGTTAGAGTTATGGTAGGCAAAAAGAAAAGGAGAATTTAGGAAATAAATATGCTATAAACAAGGTACAGTACAGTGAGAGTT
AACAATCCTAGGAATCCTGCCTGTCACAAGCTCCCAGTTCCCTGTCATTTTATCTTCATGATTAGAACTGATCTTCCATTTAACTATTAC
AGAAAGCAGTAACTATTGCAACTATCTAATAGTTCACACAAAAGAATTAAAAGCTTAAAAATAATTTTTAGGAAACACAATATTCAAAAT
CTAAACACACTGATAAATTATTAAGATTAAGATTATTTATGTGATAAATGAAATCTCCTACCAATCCATCCAGCCTTTACCAGGGAAGAA
AAGCAATTATTTCATTTCAGATAGAAATACAAAAAAAAAAAAAATACTTTTCTTAGAAGCCAGATATGGTTTAAATGTTTTATTATCCAT
AATGATCTAAACTAATAAGATTCACCAAAAAGTAAAAATTCAATTTTACAATATACATTTTTTTTTTTAACTATTTGGCTTTACCTTTTT
ACCTTGGTTCTCCTTACTGAAGTCCTCTTGCTTTCACTTTGATCTGGTTTTTGAAGTCTCTTAATTATTGGCTGGGCATGGTGACTCATG
CCTGTAATCCCGGCACTTTGGGAGGCCAAGGGAGGTGATCACTTGAGCCCAGGAGTAAAGACCAGCCTGGGCAACATAGTGAGACTCCGT
CTCTACAAAAAATAAATTTAGCTGGGCATGGTGGTGCACATCTGTAGTCCTACCAACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAGCC
CCAGGCTTCGAGGCTGCAGTGAGCTATGATTACGACACTGCACTCCAGCCTAGGCGACAGAGCAAGACCCCATTCTCTTACAAAGTCTCT
ATTATAAAAGTACATCCATCAATACCATTCCATTTAAAATGGGCTATTGTAATTTACCCACATTATCACATTTTCAGGAATTATAAGAAT
GTGTTTTATTGTACTCCTTCCTTGGAGCTGAATGCAAGGAATGTGAATTCTGAGGAATTAAGGTAGAATATATTTGACTTTCTGGTAAAG
ATCATGGTTAAGTATAATCATTACTGCCAAACTGGAATTTTCAAGTTATTATAATATCCCAGGCCCCTTGATAAAAGCTGAGGGTTATCA
TGACCTTAATGCTAATTCAATGAGAAATGAGTTTAATAGCATAACATTACCAAGGTAATCAAACTAATAAAATTCCATATATCTTCCCTG
CATCTTGTCACTGTGTACCATTCAAAGTGTTTATAAAACTCTAGATTCATCAAATGAGATTTGCTCAGCTTTTTGAAATGTTAAGATGTG

>31347_31347_1_FRMD4B-PPP2R3A_FRMD4B_chr3_69271009_ENST00000398540_PPP2R3A_chr3_135863885_ENST00000264977_length(amino acids)=284AA_BP=244
MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVAS
HFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL
AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVHFEDYETDEPASPSEFGNKSNKILSAS

--------------------------------------------------------------
>31347_31347_2_FRMD4B-PPP2R3A_FRMD4B_chr3_69271009_ENST00000398540_PPP2R3A_chr3_135863885_ENST00000334546_length(transcript)=1210nt_BP=815nt
CGGGAGCCCAGGCGGGCAGGCCGCTGGGGTCGGGGCTGCACGTACGAGAGCCGGGACGCCCGGGTTCAGAGCGAAGGAGGAGGCATGGCT
TCGGTGTTCATGTGTGGCGTGGAGGACCTGCTGTTCAGCGGCAGCCGCTTCGTATGGAACTTGACCGTGTCCACGCTGCGGAGATGGTAC
ACGGAGAGGCTGCGGGCTTGCCACCAGGTGCTGCGGACGTGGTGCGGGCTGCAGGACGTGTACCAGATGACAGAAGGCAGGCACTGCCAG
GTGCACCTCCTGGATGATAGGAGACTGGAGCTGCTGGTTCAGCCCAAACTTCTAGCAAGAGAGTTGCTGGACCTAGTGGCTTCACATTTC
AACCTGAAAGAAAAGGAGTATTTTGGAATAACATTCATAGATGACACAGGTCAGCAGAACTGGCTGCAGTTAGATCACCGAGTTCTTGAC
CACGATTTGCCCAAGAAACCAGGCCCAACCATTTTGCACTTTGCTGTGAGGTTTTACATTGAGAGCATATCGTTTTTAAAGGATAAAACC
ACCGTGGAGCTGTTTTTCCTGAATGCAAAGGCCTGTGTGCACAAGGGGCAAATCGAAGTAGAGAGCGAAACCATCTTCAAGTTAGCAGCG
TTTATTTTACAGGAAGCCAAGGGAGATTATACCAGTGATGAAAATGCCAGGAAAGATTTAAAGACATTACCAGCCTTTCCAACCAAAACT
CTTCAGGAGCATCCATCCCTTGCCTACTGTGAGGACAGGGTAATTGAGCATTATTTGAAAATCAAAGGTCTCACTCGAGGTCAAGCTGTG
GTTCACTTTGAAGATTATGAAACAGATGAACCTGCCTCTCCCTCTGAATTTGGAAACAAAAGCAATAAAATATTAAGTGCAAGCCTTCCA
GAGAAATGTGGAAAGCTTCAATCAGTGGATGAAGAATAGCTGCCGGTGTCTACAATGAAACGAAGATGTGTATTTTAAATGTTTCTTTCT
TGTGAAGAGATGTTCTCGTTTGCATACTGCTTTTTAAAGACTTTGATTTCTCCAAGTGTGTATCATCTGCACTAGGAACTTTGTTTTTAA
GCAATAGGTCTGGATACACATTTAACTTAGGAGGCTCCTCCAATTTGCCTCAAACCTCTTACGGAGCTTCTCCTCAGAAGTGGTACCATC

>31347_31347_2_FRMD4B-PPP2R3A_FRMD4B_chr3_69271009_ENST00000398540_PPP2R3A_chr3_135863885_ENST00000334546_length(amino acids)=284AA_BP=244
MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVAS
HFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL
AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVHFEDYETDEPASPSEFGNKSNKILSAS

--------------------------------------------------------------
>31347_31347_3_FRMD4B-PPP2R3A_FRMD4B_chr3_69271009_ENST00000542259_PPP2R3A_chr3_135863885_ENST00000490467_length(transcript)=1363nt_BP=1021nt
CGAGGGCCAGCTTGGTGGAGCTTAGCACAGCTTGCTCGGCGCTGCGAGCGGGCGGGGGTGGACACTGGGCTTCTGTGTGCCAGTCGCAGC
CGTTGGCTGGCGGGCACCCAATCCCAGGGCATGCCGCCGGAGCCTGGCCAGGACGCACGGTGAAAGACGAGTTTGGTGGCAGGCTTGACC
CCCCGGCTGCCAGCAGAAGCCGGCGTCGGGAGCCCAGGCGGGCAGGCCGCTGGGGTCGGGGCTGCACGTACGAGAGCCGGGACGCCCGGG
TTCAGAGCGAAGGAGGAGGCATGGCTTCGGTGTTCATGTGTGGCGTGGAGGACCTGCTGTTCAGCGGCAGCCGCTTCGTATGGAACTTGA
CCGTGTCCACGCTGCGGAGATGGTACACGGAGAGGCTGCGGGCTTGCCACCAGGTGCTGCGGACGTGGTGCGGGCTGCAGGACGTGTACC
AGATGACAGAAGGCAGGCACTGCCAGGTGCACCTCCTGGATGATAGGAGACTGGAGCTGCTGGTTCAGCCCAAACTTCTAGCAAGAGAGT
TGCTGGACCTAGTGGCTTCACATTTCAACCTGAAAGAAAAGGAGTATTTTGGAATAACATTCATAGATGACACAGGTCAGCAGAACTGGC
TGCAGTTAGATCACCGAGTTCTTGACCACGATTTGCCCAAGAAACCAGGCCCAACCATTTTGCACTTTGCTGTGAGGTTTTACATTGAGA
GCATATCGTTTTTAAAGGATAAAACCACCGTGGAGCTGTTTTTCCTGAATGCAAAGGCCTGTGTGCACAAGGGGCAAATCGAAGTAGAGA
GCGAAACCATCTTCAAGTTAGCAGCGTTTATTTTACAGTCTCCCAAAGTCTCGCTTACCCATGATGAAAATGCCAGGAAAGATTTAAAGA
CATTACCAGCCTTTCCAACCAAAACTCTTCAGGAGCATCCATCCCTTGCCTACTGTGAGGACAGGGTAATTGAGCATTATTTGAAAATCA
AAGGTCTCACTCGAGGTCAAGCTGTGGTTCACTTTGAAGATTATGAAACAGATGAACCTGCCTCTCCCTCTGAATTTGGAAACAAAAGCA
ATAAAATATTAAGTGCAAGCCTTCCAGAGAAATGTGGAAAGCTTCAATCAGTGGATGAAGAATAGCTGCCGGTGTCTACAATGAAACGAA
GATGTGTATTTTAAATGTTTCTTTCTTGTGAAGAGATGTTCTCGTTTGCATACTGCTTTTTAAAGACTTTGATTTCTCCAAGTGTGTATC
ATCTGCACTAGGAACTTTGTTTTTAAGCAATAGGTCTGGATACACATTTAACTTAGGAGGCTCCTCCAATTTGCCTCAAACCTCTTACGG

>31347_31347_3_FRMD4B-PPP2R3A_FRMD4B_chr3_69271009_ENST00000542259_PPP2R3A_chr3_135863885_ENST00000490467_length(amino acids)=377AA_BP=337
MVELSTACSALRAGGGGHWASVCQSQPLAGGHPIPGHAAGAWPGRTVKDEFGGRLDPPAASRSRRREPRRAGRWGRGCTYESRDARVQSE
GGGMASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDL
VASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETI
FKLAAFILQSPKVSLTHDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVHFEDYETDEPASPSEFGNKSNKIL

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Fusion Gene PPI Analysis for FRMD4B-PPP2R3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FRMD4B-PPP2R3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FRMD4B-PPP2R3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource