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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AHRR-AVIL (FusionGDB2 ID:3138)

Fusion Gene Summary for AHRR-AVIL

check button Fusion gene summary
Fusion gene informationFusion gene name: AHRR-AVIL
Fusion gene ID: 3138
HgeneTgene
Gene symbol

AHRR

AVIL

Gene ID

57491

10677

Gene namearyl-hydrocarbon receptor repressoradvillin
SynonymsAHH|AHHR|bHLHe77ADVIL|DOC6|NPHS21|p92
Cytomap

5p15.33

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionaryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressoradvillin
Modification date2020032220200313
UniProtAcc

A9YTQ3

O75366

Ensembl transtripts involved in fusion geneENST00000316418, ENST00000505113, 
ENST00000506456, ENST00000512529, 
ENST00000515206, 		ENST00000550083, 
ENST00000257861, ENST00000537081, 
Fusion gene scores* DoF score6 X 6 X 4=14420 X 12 X 9=2160
# samples 720
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2160*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHRR [Title/Abstract] AND AVIL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAHRR(376831)-AVIL(58193703), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AHRR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AVIL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A2IZ-01AAHRRchr5

376831

-AVILchr12

58193703

-
ChimerDB4SARCTCGA-DX-A2IZ-01AAHRRchr5

376831

+AVILchr12

58193703

-


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Fusion Gene ORF analysis for AHRR-AVIL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000316418ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
5CDS-intronENST00000505113ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
In-frameENST00000316418ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
In-frameENST00000316418ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
In-frameENST00000505113ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
In-frameENST00000505113ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000506456ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000506456ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000512529ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000512529ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000515206ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000515206ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
intron-intronENST00000506456ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
intron-intronENST00000512529ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
intron-intronENST00000515206ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000505113AHRRchr5376831+ENST00000537081AVILchr1258193703-114740744646200
ENST00000505113AHRRchr5376831+ENST00000257861AVILchr1258193703-64740744646201
ENST00000316418AHRRchr5376831+ENST00000537081AVILchr1258193703-114740744646200
ENST00000316418AHRRchr5376831+ENST00000257861AVILchr1258193703-64740744646201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000505113ENST00000537081AHRRchr5376831+AVILchr1258193703-0.0071976710.9928023
ENST00000505113ENST00000257861AHRRchr5376831+AVILchr1258193703-0.0116397890.98836017
ENST00000316418ENST00000537081AHRRchr5376831+AVILchr1258193703-0.0071976710.9928023
ENST00000316418ENST00000257861AHRRchr5376831+AVILchr1258193703-0.0116397890.98836017

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Fusion Genomic Features for AHRR-AVIL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AHRR-AVIL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:376831/chr12:58193703)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHRR

A9YTQ3

AVIL

O75366

FUNCTION: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}.FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHRRchr5:376831chr12:58193703ENST00000316418+41228_81121720.0DomainbHLH
HgeneAHRRchr5:376831chr12:58193703ENST00000505113+41128_81121702.0DomainbHLH
TgeneAVILchr5:376831chr12:58193703ENST000002578611619753_819740820.0DomainHP
TgeneAVILchr5:376831chr12:58193703ENST000005370811619753_819733813.0DomainHP
TgeneAVILchr5:376831chr12:58193703ENST000005370811619731_819733813.0RegionHeadpiece

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHRRchr5:376831chr12:58193703ENST00000316418+412112_182121720.0DomainPAS
HgeneAHRRchr5:376831chr12:58193703ENST00000505113+411112_182121702.0DomainPAS
HgeneAHRRchr5:376831chr12:58193703ENST00000316418+412551_701121720.0RegionNeeded for transcriptional repression
HgeneAHRRchr5:376831chr12:58193703ENST00000505113+411551_701121702.0RegionNeeded for transcriptional repression
TgeneAVILchr5:376831chr12:58193703ENST000002578611619109_116740820.0RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST000002578611619135_143740820.0RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST0000025786116191_731740820.0RegionCore
TgeneAVILchr5:376831chr12:58193703ENST000002578611619731_819740820.0RegionHeadpiece
TgeneAVILchr5:376831chr12:58193703ENST000005370811619109_116733813.0RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST000005370811619135_143733813.0RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST0000053708116191_731733813.0RegionCore
TgeneAVILchr5:376831chr12:58193703ENST000002578611619145_185740820.0RepeatNote=Gelsolin-like 2
TgeneAVILchr5:376831chr12:58193703ENST00000257861161924_73740820.0RepeatNote=Gelsolin-like 1
TgeneAVILchr5:376831chr12:58193703ENST000002578611619262_306740820.0RepeatNote=Gelsolin-like 3
TgeneAVILchr5:376831chr12:58193703ENST000002578611619403_454740820.0RepeatNote=Gelsolin-like 4
TgeneAVILchr5:376831chr12:58193703ENST000002578611619525_565740820.0RepeatNote=Gelsolin-like 5
TgeneAVILchr5:376831chr12:58193703ENST000002578611619628_669740820.0RepeatNote=Gelsolin-like 6
TgeneAVILchr5:376831chr12:58193703ENST000005370811619145_185733813.0RepeatNote=Gelsolin-like 2
TgeneAVILchr5:376831chr12:58193703ENST00000537081161924_73733813.0RepeatNote=Gelsolin-like 1
TgeneAVILchr5:376831chr12:58193703ENST000005370811619262_306733813.0RepeatNote=Gelsolin-like 3
TgeneAVILchr5:376831chr12:58193703ENST000005370811619403_454733813.0RepeatNote=Gelsolin-like 4
TgeneAVILchr5:376831chr12:58193703ENST000005370811619525_565733813.0RepeatNote=Gelsolin-like 5
TgeneAVILchr5:376831chr12:58193703ENST000005370811619628_669733813.0RepeatNote=Gelsolin-like 6


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Fusion Gene Sequence for AHRR-AVIL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3138_3138_1_AHRR-AVIL_AHRR_chr5_376831_ENST00000316418_AVIL_chr12_58193703_ENST00000257861_length(transcript)=647nt_BP=407nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG

>3138_3138_1_AHRR-AVIL_AHRR_chr5_376831_ENST00000316418_AVIL_chr12_58193703_ENST00000257861_length(amino acids)=201AA_BP=121
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

--------------------------------------------------------------
>3138_3138_2_AHRR-AVIL_AHRR_chr5_376831_ENST00000316418_AVIL_chr12_58193703_ENST00000537081_length(transcript)=1147nt_BP=407nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG
AAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATC
CACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGC
ATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAA
ACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGA
CCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAA

>3138_3138_2_AHRR-AVIL_AHRR_chr5_376831_ENST00000316418_AVIL_chr12_58193703_ENST00000537081_length(amino acids)=200AA_BP=121
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

--------------------------------------------------------------
>3138_3138_3_AHRR-AVIL_AHRR_chr5_376831_ENST00000505113_AVIL_chr12_58193703_ENST00000257861_length(transcript)=647nt_BP=407nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG

>3138_3138_3_AHRR-AVIL_AHRR_chr5_376831_ENST00000505113_AVIL_chr12_58193703_ENST00000257861_length(amino acids)=201AA_BP=121
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

--------------------------------------------------------------
>3138_3138_4_AHRR-AVIL_AHRR_chr5_376831_ENST00000505113_AVIL_chr12_58193703_ENST00000537081_length(transcript)=1147nt_BP=407nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG
AAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATC
CACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGC
ATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAA
ACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGA
CCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAA

>3138_3138_4_AHRR-AVIL_AHRR_chr5_376831_ENST00000505113_AVIL_chr12_58193703_ENST00000537081_length(amino acids)=200AA_BP=121
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AHRR-AVIL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AHRR-AVIL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AHRR-AVIL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource