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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:FRMD8-MARK2 (FusionGDB2 ID:31380) |
Fusion Gene Summary for FRMD8-MARK2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FRMD8-MARK2 | Fusion gene ID: 31380 | Hgene | Tgene | Gene symbol | FRMD8 | MARK2 | Gene ID | 83786 | 2011 |
Gene name | FERM domain containing 8 | microtubule affinity regulating kinase 2 | |
Synonyms | FKSG44|iTAP | EMK-1|EMK1|PAR-1|Par-1b|Par1b | |
Cytomap | 11q13.1 | 11q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | FERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Protein | serine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117 | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | Q9BZ67 | Q7KZI7 | |
Ensembl transtripts involved in fusion gene | ENST00000317568, ENST00000355991, ENST00000416776, ENST00000531296, | ENST00000315032, ENST00000350490, ENST00000361128, ENST00000377810, ENST00000502399, ENST00000508192, ENST00000509502, ENST00000513765, ENST00000408948, ENST00000425897, ENST00000377809, ENST00000402010, ENST00000413835, | |
Fusion gene scores | * DoF score | 11 X 8 X 8=704 | 7 X 6 X 3=126 |
# samples | 16 | 10 | |
** MAII score | log2(16/704*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/126*10)=-0.333423733725192 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FRMD8 [Title/Abstract] AND MARK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FRMD8(65154592)-MARK2(63662631), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | FRMD8-MARK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FRMD8-MARK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FRMD8 | GO:1904469 | positive regulation of tumor necrosis factor secretion | 29897333 |
Tgene | MARK2 | GO:0006468 | protein phosphorylation | 14976552 |
Tgene | MARK2 | GO:0010976 | positive regulation of neuron projection development | 12429843 |
Tgene | MARK2 | GO:0018105 | peptidyl-serine phosphorylation | 10542369|16717194 |
Tgene | MARK2 | GO:0030010 | establishment of cell polarity | 12429843 |
Tgene | MARK2 | GO:0035556 | intracellular signal transduction | 14976552 |
Tgene | MARK2 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 15324659 |
Tgene | MARK2 | GO:0070507 | regulation of microtubule cytoskeleton organization | 10542369 |
Fusion gene breakpoints across FRMD8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MARK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-VQ-A92D-01A | FRMD8 | chr11 | 65154592 | - | MARK2 | chr11 | 63662631 | + |
ChimerDB4 | STAD | TCGA-VQ-A92D-01A | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
ChimerDB4 | STAD | TCGA-VQ-A92D | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
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Fusion Gene ORF analysis for FRMD8-MARK2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000317568 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000317568 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000317568 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000317568 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000317568 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000317568 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000317568 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000317568 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000317568 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000355991 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000355991 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000416776 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000416776 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000315032 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000350490 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000361128 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000377810 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000502399 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000508192 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000509502 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-5UTR | ENST00000531296 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-5UTR | ENST00000531296 | ENST00000513765 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000317568 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000317568 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000317568 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000317568 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000355991 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000355991 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000355991 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000355991 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000416776 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000416776 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000416776 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000416776 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000531296 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000531296 | ENST00000408948 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
5CDS-intron | ENST00000531296 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
5CDS-intron | ENST00000531296 | ENST00000425897 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000317568 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000317568 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000317568 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000317568 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000317568 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000317568 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000355991 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000355991 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000355991 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000355991 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000355991 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000355991 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000416776 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000416776 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000416776 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000416776 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
Frame-shift | ENST00000416776 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
Frame-shift | ENST00000416776 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
In-frame | ENST00000531296 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
In-frame | ENST00000531296 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
In-frame | ENST00000531296 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
In-frame | ENST00000531296 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
In-frame | ENST00000531296 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + |
In-frame | ENST00000531296 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000531296 | FRMD8 | chr11 | 65154592 | + | ENST00000377809 | MARK2 | chr11 | 63662631 | + | 4331 | 281 | 287 | 2548 | 753 |
ENST00000531296 | FRMD8 | chr11 | 65154592 | + | ENST00000402010 | MARK2 | chr11 | 63662631 | + | 4376 | 281 | 287 | 2593 | 768 |
ENST00000531296 | FRMD8 | chr11 | 65154592 | + | ENST00000413835 | MARK2 | chr11 | 63662631 | + | 4214 | 281 | 287 | 2431 | 714 |
ENST00000531296 | FRMD8 | chr11 | 65154592 | + | ENST00000377809 | MARK2 | chr11 | 63662630 | + | 4331 | 281 | 287 | 2548 | 753 |
ENST00000531296 | FRMD8 | chr11 | 65154592 | + | ENST00000402010 | MARK2 | chr11 | 63662630 | + | 4376 | 281 | 287 | 2593 | 768 |
ENST00000531296 | FRMD8 | chr11 | 65154592 | + | ENST00000413835 | MARK2 | chr11 | 63662630 | + | 4214 | 281 | 287 | 2431 | 714 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000531296 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + | 0.003183956 | 0.9968161 |
ENST00000531296 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + | 0.003016098 | 0.99698395 |
ENST00000531296 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662631 | + | 0.003103912 | 0.996896 |
ENST00000531296 | ENST00000377809 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + | 0.003183956 | 0.9968161 |
ENST00000531296 | ENST00000402010 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + | 0.003016098 | 0.99698395 |
ENST00000531296 | ENST00000413835 | FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662630 | + | 0.003103912 | 0.996896 |
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Fusion Genomic Features for FRMD8-MARK2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662626 | + | 4.91E-08 | 1 |
FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662626 | + | 4.91E-08 | 1 |
FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662626 | + | 4.91E-08 | 1 |
FRMD8 | chr11 | 65154592 | + | MARK2 | chr11 | 63662626 | + | 4.91E-08 | 1 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FRMD8-MARK2 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65154592/chr11:63662631) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FRMD8 | MARK2 |
FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. | FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000315032 | 0 | 18 | 323_362 | 18 | 780.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000315032 | 0 | 18 | 53_304 | 18 | 780.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000315032 | 0 | 18 | 739_788 | 18 | 780.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000350490 | 0 | 16 | 323_362 | 18 | 710.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000350490 | 0 | 16 | 53_304 | 18 | 710.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000350490 | 0 | 16 | 739_788 | 18 | 710.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000361128 | 0 | 17 | 323_362 | 18 | 720.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000361128 | 0 | 17 | 53_304 | 18 | 720.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000361128 | 0 | 17 | 739_788 | 18 | 720.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377809 | 0 | 18 | 323_362 | 18 | 774.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377809 | 0 | 18 | 53_304 | 18 | 774.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377809 | 0 | 18 | 739_788 | 18 | 774.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377810 | 0 | 17 | 323_362 | 0 | 692.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377810 | 0 | 17 | 53_304 | 0 | 692.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377810 | 0 | 17 | 739_788 | 0 | 692.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000402010 | 0 | 19 | 323_362 | 18 | 789.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000402010 | 0 | 19 | 53_304 | 18 | 789.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000402010 | 0 | 19 | 739_788 | 18 | 789.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000408948 | 0 | 16 | 323_362 | 0 | 692.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000408948 | 0 | 16 | 53_304 | 0 | 692.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000408948 | 0 | 16 | 739_788 | 0 | 692.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000413835 | 0 | 18 | 323_362 | 18 | 735.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000413835 | 0 | 18 | 53_304 | 18 | 735.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000413835 | 0 | 18 | 739_788 | 18 | 735.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000508192 | 0 | 17 | 323_362 | 18 | 725.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000508192 | 0 | 17 | 53_304 | 18 | 725.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000508192 | 0 | 17 | 739_788 | 18 | 725.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000509502 | 0 | 18 | 323_362 | 0 | 746.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000509502 | 0 | 18 | 53_304 | 0 | 746.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000509502 | 0 | 18 | 739_788 | 0 | 746.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000513765 | -1 | 18 | 323_362 | 45 | 756.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000513765 | -1 | 18 | 53_304 | 45 | 756.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000513765 | -1 | 18 | 739_788 | 45 | 756.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000315032 | 0 | 18 | 323_362 | 18 | 780.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000315032 | 0 | 18 | 53_304 | 18 | 780.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000315032 | 0 | 18 | 739_788 | 18 | 780.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000350490 | 0 | 16 | 323_362 | 18 | 710.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000350490 | 0 | 16 | 53_304 | 18 | 710.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000350490 | 0 | 16 | 739_788 | 18 | 710.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000361128 | 0 | 17 | 323_362 | 18 | 720.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000361128 | 0 | 17 | 53_304 | 18 | 720.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000361128 | 0 | 17 | 739_788 | 18 | 720.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377809 | 0 | 18 | 323_362 | 18 | 774.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377809 | 0 | 18 | 53_304 | 18 | 774.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377809 | 0 | 18 | 739_788 | 18 | 774.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377810 | 0 | 17 | 323_362 | 0 | 692.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377810 | 0 | 17 | 53_304 | 0 | 692.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377810 | 0 | 17 | 739_788 | 0 | 692.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000402010 | 0 | 19 | 323_362 | 18 | 789.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000402010 | 0 | 19 | 53_304 | 18 | 789.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000402010 | 0 | 19 | 739_788 | 18 | 789.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000408948 | 0 | 16 | 323_362 | 0 | 692.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000408948 | 0 | 16 | 53_304 | 0 | 692.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000408948 | 0 | 16 | 739_788 | 0 | 692.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000413835 | 0 | 18 | 323_362 | 18 | 735.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000413835 | 0 | 18 | 53_304 | 18 | 735.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000413835 | 0 | 18 | 739_788 | 18 | 735.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000508192 | 0 | 17 | 323_362 | 18 | 725.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000508192 | 0 | 17 | 53_304 | 18 | 725.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000508192 | 0 | 17 | 739_788 | 18 | 725.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000509502 | 0 | 18 | 323_362 | 0 | 746.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000509502 | 0 | 18 | 53_304 | 0 | 746.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000509502 | 0 | 18 | 739_788 | 0 | 746.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000513765 | -1 | 18 | 323_362 | 45 | 756.0 | Domain | UBA | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000513765 | -1 | 18 | 53_304 | 45 | 756.0 | Domain | Protein kinase | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000513765 | -1 | 18 | 739_788 | 45 | 756.0 | Domain | KA1 | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000315032 | 0 | 18 | 59_67 | 18 | 780.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000350490 | 0 | 16 | 59_67 | 18 | 710.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000361128 | 0 | 17 | 59_67 | 18 | 720.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377809 | 0 | 18 | 59_67 | 18 | 774.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000377810 | 0 | 17 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000402010 | 0 | 19 | 59_67 | 18 | 789.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000408948 | 0 | 16 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000413835 | 0 | 18 | 59_67 | 18 | 735.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000508192 | 0 | 17 | 59_67 | 18 | 725.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000509502 | 0 | 18 | 59_67 | 0 | 746.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662630 | ENST00000513765 | -1 | 18 | 59_67 | 45 | 756.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000315032 | 0 | 18 | 59_67 | 18 | 780.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000350490 | 0 | 16 | 59_67 | 18 | 710.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000361128 | 0 | 17 | 59_67 | 18 | 720.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377809 | 0 | 18 | 59_67 | 18 | 774.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000377810 | 0 | 17 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000402010 | 0 | 19 | 59_67 | 18 | 789.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000408948 | 0 | 16 | 59_67 | 0 | 692.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000413835 | 0 | 18 | 59_67 | 18 | 735.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000508192 | 0 | 17 | 59_67 | 18 | 725.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000509502 | 0 | 18 | 59_67 | 0 | 746.0 | Nucleotide binding | ATP | |
Tgene | MARK2 | chr11:65154592 | chr11:63662631 | ENST00000513765 | -1 | 18 | 59_67 | 45 | 756.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | FRMD8 | chr11:65154592 | chr11:63662630 | ENST00000317568 | + | 2 | 11 | 30_376 | 28 | 465.0 | Domain | FERM |
Hgene | FRMD8 | chr11:65154592 | chr11:63662630 | ENST00000355991 | + | 2 | 10 | 30_376 | 28 | 409.0 | Domain | FERM |
Hgene | FRMD8 | chr11:65154592 | chr11:63662631 | ENST00000317568 | + | 2 | 11 | 30_376 | 28 | 465.0 | Domain | FERM |
Hgene | FRMD8 | chr11:65154592 | chr11:63662631 | ENST00000355991 | + | 2 | 10 | 30_376 | 28 | 409.0 | Domain | FERM |
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Fusion Gene Sequence for FRMD8-MARK2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>31380_31380_1_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000377809_length(transcript)=4331nt_BP=281nt CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA GAAATCTGTCTTTCAGGTTTGCCAGAAGACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGC CCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACG CGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGA TGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCT CCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCG CCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTT ACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGG CAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTA TTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTT CCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTC CCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGG GCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTC CGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAA AGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGG CTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGC ACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCA CCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGC TGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGC CAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAA TTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTAT TTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTT GCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCC CCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACC CAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCCTGCACTTAGTTTCTCCTCTGGATCAAACACGTAATAAAGAGAATG >31380_31380_1_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000377809_length(amino acids)=753AA_BP= MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR FARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKL -------------------------------------------------------------- >31380_31380_2_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000402010_length(transcript)=4376nt_BP=281nt CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA GAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCAGACCTCACGTGGTGGGCA GTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCA TGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGT GCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGAT TTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCG GGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCC CCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATT CACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGT ACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTT CCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGG TGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGC CTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGG GGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTG GGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGC TGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGC AGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGG CATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGC CCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGG GGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCA CTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTG AGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCA TCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCAC ACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGG GAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCC >31380_31380_2_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000402010_length(amino acids)=768AA_BP= MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR FARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTP -------------------------------------------------------------- >31380_31380_3_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000413835_length(transcript)=4214nt_BP=281nt CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG GCCAGGCCTCCATCCAGAATGGCAAAGACAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTG GTGGAGCCCCAGACCGAACTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGC AGAATTTGCCCTACGGTGTGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCA CCTCCAAGTTTGTACGCAGAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCA GACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTA TGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATG AGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCT CTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTT AACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCG ATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGT TCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGG GCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAA ATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAAC ACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAG CAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCC TGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGC CCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTC CCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGG GCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCA TGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTT TCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGT CTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCG CTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGC TGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGA TGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACC TCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGG GTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAG >31380_31380_3_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000413835_length(amino acids)=714AA_BP= MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYG VTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSS -------------------------------------------------------------- >31380_31380_4_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000377809_length(transcript)=4331nt_BP=281nt CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA GAAATCTGTCTTTCAGGTTTGCCAGAAGACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGC CCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACG CGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGA TGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCT CCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCG CCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTT ACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGG CAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTA TTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTT CCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTC CCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGG GCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTC CGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAA AGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGG CTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGC ACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCA CCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGC TGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGC CAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAA TTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTAT TTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTT GCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCC CCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACC CAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCCTGCACTTAGTTTCTCCTCTGGATCAAACACGTAATAAAGAGAATG >31380_31380_4_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000377809_length(amino acids)=753AA_BP= MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR FARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKL -------------------------------------------------------------- >31380_31380_5_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000402010_length(transcript)=4376nt_BP=281nt CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA GAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCAGACCTCACGTGGTGGGCA GTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCA TGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGT GCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGAT TTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCG GGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCC CCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATT CACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGT ACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTT CCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGG TGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGC CTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGG GGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTG GGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGC TGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGC AGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGG CATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGC CCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGG GGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCA CTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTG AGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCA TCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCAC ACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGG GAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCC >31380_31380_5_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000402010_length(amino acids)=768AA_BP= MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR FARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTP -------------------------------------------------------------- >31380_31380_6_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000413835_length(transcript)=4214nt_BP=281nt CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG GCCAGGCCTCCATCCAGAATGGCAAAGACAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTG GTGGAGCCCCAGACCGAACTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGC AGAATTTGCCCTACGGTGTGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCA CCTCCAAGTTTGTACGCAGAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCA GACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTA TGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATG AGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCT CTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTT AACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCG ATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGT TCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGG GCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAA ATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAAC ACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAG CAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCC TGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGC CCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTC CCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGG GCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCA TGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTT TCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGT CTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCG CTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGC TGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGA TGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACC TCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGG GTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAG >31380_31380_6_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000413835_length(amino acids)=714AA_BP= MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYG VTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FRMD8-MARK2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FRMD8-MARK2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FRMD8-MARK2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |