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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FRMD8-MARK2 (FusionGDB2 ID:31380)

Fusion Gene Summary for FRMD8-MARK2

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD8-MARK2
Fusion gene ID: 31380
HgeneTgene
Gene symbol

FRMD8

MARK2

Gene ID

83786

2011

Gene nameFERM domain containing 8microtubule affinity regulating kinase 2
SynonymsFKSG44|iTAPEMK-1|EMK1|PAR-1|Par-1b|Par1b
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Proteinserine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117
Modification date2020031320200329
UniProtAcc

Q9BZ67

Q7KZI7

Ensembl transtripts involved in fusion geneENST00000317568, ENST00000355991, 
ENST00000416776, ENST00000531296, 
ENST00000315032, ENST00000350490, 
ENST00000361128, ENST00000377810, 
ENST00000502399, ENST00000508192, 
ENST00000509502, ENST00000513765, 
ENST00000408948, ENST00000425897, 
ENST00000377809, ENST00000402010, 
ENST00000413835, 
Fusion gene scores* DoF score11 X 8 X 8=7047 X 6 X 3=126
# samples 1610
** MAII scorelog2(16/704*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRMD8 [Title/Abstract] AND MARK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRMD8(65154592)-MARK2(63662631), # samples:2
Anticipated loss of major functional domain due to fusion event.FRMD8-MARK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FRMD8-MARK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFRMD8

GO:1904469

positive regulation of tumor necrosis factor secretion

29897333

TgeneMARK2

GO:0006468

protein phosphorylation

14976552

TgeneMARK2

GO:0010976

positive regulation of neuron projection development

12429843

TgeneMARK2

GO:0018105

peptidyl-serine phosphorylation

10542369|16717194

TgeneMARK2

GO:0030010

establishment of cell polarity

12429843

TgeneMARK2

GO:0035556

intracellular signal transduction

14976552

TgeneMARK2

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

15324659

TgeneMARK2

GO:0070507

regulation of microtubule cytoskeleton organization

10542369


check buttonFusion gene breakpoints across FRMD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A92D-01AFRMD8chr11

65154592

-MARK2chr11

63662631

+
ChimerDB4STADTCGA-VQ-A92D-01AFRMD8chr11

65154592

+MARK2chr11

63662631

+
ChimerDB4STADTCGA-VQ-A92DFRMD8chr11

65154592

+MARK2chr11

63662630

+


Top

Fusion Gene ORF analysis for FRMD8-MARK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000317568ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000317568ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000317568ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000317568ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000317568ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000317568ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000317568ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000317568ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000317568ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000355991ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000355991ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000416776ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000416776ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000315032FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000350490FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000361128FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000377810FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000502399FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000508192FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000509502FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-5UTRENST00000531296ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-5UTRENST00000531296ENST00000513765FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000317568ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000317568ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000317568ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000317568ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000355991ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000355991ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000355991ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000355991ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000416776ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000416776ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000416776ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000416776ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000531296ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000531296ENST00000408948FRMD8chr11

65154592

+MARK2chr11

63662630

+
5CDS-intronENST00000531296ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662631

+
5CDS-intronENST00000531296ENST00000425897FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000317568ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000317568ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000317568ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000317568ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000317568ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000317568ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000355991ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000355991ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000355991ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000355991ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000355991ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000355991ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000416776ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000416776ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000416776ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000416776ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662630

+
Frame-shiftENST00000416776ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662631

+
Frame-shiftENST00000416776ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662630

+
In-frameENST00000531296ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662631

+
In-frameENST00000531296ENST00000377809FRMD8chr11

65154592

+MARK2chr11

63662630

+
In-frameENST00000531296ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662631

+
In-frameENST00000531296ENST00000402010FRMD8chr11

65154592

+MARK2chr11

63662630

+
In-frameENST00000531296ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662631

+
In-frameENST00000531296ENST00000413835FRMD8chr11

65154592

+MARK2chr11

63662630

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000531296FRMD8chr1165154592+ENST00000377809MARK2chr1163662631+43312812872548753
ENST00000531296FRMD8chr1165154592+ENST00000402010MARK2chr1163662631+43762812872593768
ENST00000531296FRMD8chr1165154592+ENST00000413835MARK2chr1163662631+42142812872431714
ENST00000531296FRMD8chr1165154592+ENST00000377809MARK2chr1163662630+43312812872548753
ENST00000531296FRMD8chr1165154592+ENST00000402010MARK2chr1163662630+43762812872593768
ENST00000531296FRMD8chr1165154592+ENST00000413835MARK2chr1163662630+42142812872431714

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000531296ENST00000377809FRMD8chr1165154592+MARK2chr1163662631+0.0031839560.9968161
ENST00000531296ENST00000402010FRMD8chr1165154592+MARK2chr1163662631+0.0030160980.99698395
ENST00000531296ENST00000413835FRMD8chr1165154592+MARK2chr1163662631+0.0031039120.996896
ENST00000531296ENST00000377809FRMD8chr1165154592+MARK2chr1163662630+0.0031839560.9968161
ENST00000531296ENST00000402010FRMD8chr1165154592+MARK2chr1163662630+0.0030160980.99698395
ENST00000531296ENST00000413835FRMD8chr1165154592+MARK2chr1163662630+0.0031039120.996896

Top

Fusion Genomic Features for FRMD8-MARK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FRMD8chr1165154592+MARK2chr1163662626+4.91E-081
FRMD8chr1165154592+MARK2chr1163662626+4.91E-081
FRMD8chr1165154592+MARK2chr1163662626+4.91E-081
FRMD8chr1165154592+MARK2chr1163662626+4.91E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FRMD8-MARK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65154592/chr11:63662631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRMD8

Q9BZ67

MARK2

Q7KZI7

FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}.FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARK2chr11:65154592chr11:63662630ENST00000315032018323_36218780.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000031503201853_30418780.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000315032018739_78818780.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000350490016323_36218710.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000035049001653_30418710.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000350490016739_78818710.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000361128017323_36218720.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000036112801753_30418720.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000361128017739_78818720.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000377809018323_36218774.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000037780901853_30418774.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000377809018739_78818774.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000377810017323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000037781001753_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000377810017739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000402010019323_36218789.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000040201001953_30418789.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000402010019739_78818789.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000408948016323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000040894801653_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000408948016739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000413835018323_36218735.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000041383501853_30418735.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000413835018739_78818735.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000508192017323_36218725.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000050819201753_30418725.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000508192017739_78818725.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000509502018323_3620746.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST0000050950201853_3040746.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000509502018739_7880746.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-118323_36245756.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-11853_30445756.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-118739_78845756.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000315032018323_36218780.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000031503201853_30418780.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000315032018739_78818780.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000350490016323_36218710.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000035049001653_30418710.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000350490016739_78818710.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000361128017323_36218720.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000036112801753_30418720.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000361128017739_78818720.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000377809018323_36218774.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000037780901853_30418774.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000377809018739_78818774.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000377810017323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000037781001753_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000377810017739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000402010019323_36218789.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000040201001953_30418789.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000402010019739_78818789.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000408948016323_3620692.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000040894801653_3040692.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000408948016739_7880692.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000413835018323_36218735.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000041383501853_30418735.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000413835018739_78818735.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000508192017323_36218725.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000050819201753_30418725.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000508192017739_78818725.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000509502018323_3620746.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST0000050950201853_3040746.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000509502018739_7880746.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-118323_36245756.0DomainUBA
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-11853_30445756.0DomainProtein kinase
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-118739_78845756.0DomainKA1
TgeneMARK2chr11:65154592chr11:63662630ENST0000031503201859_6718780.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000035049001659_6718710.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000036112801759_6718720.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000037780901859_6718774.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000037781001759_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000040201001959_6718789.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000040894801659_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000041383501859_6718735.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000050819201759_6718725.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST0000050950201859_670746.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662630ENST00000513765-11859_6745756.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000031503201859_6718780.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000035049001659_6718710.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000036112801759_6718720.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000037780901859_6718774.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000037781001759_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000040201001959_6718789.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000040894801659_670692.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000041383501859_6718735.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000050819201759_6718725.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST0000050950201859_670746.0Nucleotide bindingATP
TgeneMARK2chr11:65154592chr11:63662631ENST00000513765-11859_6745756.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD8chr11:65154592chr11:63662630ENST00000317568+21130_37628465.0DomainFERM
HgeneFRMD8chr11:65154592chr11:63662630ENST00000355991+21030_37628409.0DomainFERM
HgeneFRMD8chr11:65154592chr11:63662631ENST00000317568+21130_37628465.0DomainFERM
HgeneFRMD8chr11:65154592chr11:63662631ENST00000355991+21030_37628409.0DomainFERM


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Fusion Gene Sequence for FRMD8-MARK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31380_31380_1_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000377809_length(transcript)=4331nt_BP=281nt
CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA
TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG
GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA
GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG
ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA
CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA
AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG
GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT
ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG
GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA
AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC
TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC
TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC
CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT
CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC
TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC
AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA
AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA
AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG
GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG
CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG
TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA
CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG
TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA
GAAATCTGTCTTTCAGGTTTGCCAGAAGACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGC
CCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACG
CGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGA
TGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCT
CCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCG
CCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTT
ACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGG
CAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTA
TTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTT
CCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTC
CCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGG
GCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTC
CGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAA
AGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGG
CTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGC
ACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCA
CCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGC
TGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGC
CAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAA
TTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTAT
TTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTT
GCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCC
CCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACC
CAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCCTGCACTTAGTTTCTCCTCTGGATCAAACACGTAATAAAGAGAATG

>31380_31380_1_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000377809_length(amino acids)=753AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKL

--------------------------------------------------------------
>31380_31380_2_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000402010_length(transcript)=4376nt_BP=281nt
CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA
TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG
GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA
GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG
ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA
CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA
AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG
GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT
ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG
GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA
AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC
TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC
TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC
CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT
CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC
TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC
AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA
AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA
AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG
GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG
CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG
TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA
CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG
TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA
GAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCAGACCTCACGTGGTGGGCA
GTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCA
TGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGT
GCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGAT
TTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCG
GGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCC
CCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATT
CACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGT
ACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTT
CCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGG
TGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGC
CTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGG
GGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTG
GGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGC
TGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGC
AGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGG
CATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGC
CCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGG
GGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCA
CTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTG
AGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCA
TCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCAC
ACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGG
GAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCC

>31380_31380_2_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000402010_length(amino acids)=768AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTP

--------------------------------------------------------------
>31380_31380_3_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000413835_length(transcript)=4214nt_BP=281nt
CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA
TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG
GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA
GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG
ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA
CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA
AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG
GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT
ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG
GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA
AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC
TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC
TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC
CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT
CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC
TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC
AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA
AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA
AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG
GCCAGGCCTCCATCCAGAATGGCAAAGACAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTG
GTGGAGCCCCAGACCGAACTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGC
AGAATTTGCCCTACGGTGTGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCA
CCTCCAAGTTTGTACGCAGAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCA
GACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTA
TGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATG
AGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCT
CTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTT
AACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCG
ATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGT
TCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGG
GCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAA
ATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAAC
ACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAG
CAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCC
TGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGC
CCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTC
CCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGG
GCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCA
TGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTT
TCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGT
CTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCG
CTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGC
TGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGA
TGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACC
TCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGG
GTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAG

>31380_31380_3_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662630_ENST00000413835_length(amino acids)=714AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYG
VTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSS

--------------------------------------------------------------
>31380_31380_4_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000377809_length(transcript)=4331nt_BP=281nt
CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA
TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG
GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA
GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG
ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA
CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA
AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG
GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT
ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG
GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA
AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC
TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC
TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC
CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT
CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC
TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC
AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA
AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA
AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG
GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG
CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG
TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA
CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG
TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA
GAAATCTGTCTTTCAGGTTTGCCAGAAGACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGC
CCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACG
CGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGA
TGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCT
CCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCG
CCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTT
ACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGG
CAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTA
TTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTT
CCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTC
CCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGG
GCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTC
CGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAA
AGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGG
CTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGC
ACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCA
CCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGC
TGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGC
CAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAA
TTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTAT
TTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTT
GCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCC
CCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACC
CAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCCTGCACTTAGTTTCTCCTCTGGATCAAACACGTAATAAAGAGAATG

>31380_31380_4_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000377809_length(amino acids)=753AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKL

--------------------------------------------------------------
>31380_31380_5_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000402010_length(transcript)=4376nt_BP=281nt
CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA
TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG
GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA
GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG
ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA
CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA
AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG
GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT
ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG
GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA
AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC
TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC
TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC
CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT
CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC
TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC
AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA
AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA
AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG
GCCAGGCCTCCATCCAGAATGGCAAAGACAGCCTAACCATGCCAGGGTCCCGGGCCTCCACGGCTTCTGCTTCTGCCGCAGTCTCTGCGG
CCCGGCCCCGCCAGCACCAGAAATCCATGTCGGCCTCCGTGCACCCCAACAAGGCCTCTGGGCTGCCCCCCACGGAGAGTAACTGTGAGG
TGCCGCGGCCCAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTGGTGGAGCCCCAGACCGAA
CTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTG
TGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCACCTCCAAGTTTGTACGCA
GAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCAGACCTCACGTGGTGGGCA
GTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTATGAAGACCACGAGCTCCA
TGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGT
GCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCTCTCTCAACGGGGTTCGAT
TTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCG
GGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCGATGGATTGGTGTGTCTCC
CCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATT
CACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGT
ACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTT
CCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGG
TGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGC
CTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGGGGCTGG
GGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTG
GGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTCCCGGGTAGAAGGAGGGGC
TGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGC
AGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGG
CATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGC
CCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGG
GGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCA
CTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCTCACCTG
AGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCA
TCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACCTCAGCCCTCCTGCCCCAC
ACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGG
GAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCC

>31380_31380_5_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000402010_length(amino acids)=768AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPST
APQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFR
FARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTP

--------------------------------------------------------------
>31380_31380_6_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000413835_length(transcript)=4214nt_BP=281nt
CCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGA
TTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGGTGGGTCCCACCCGCATCTCCTCTTCCACACCCTCCTGG
GACCCCAGCCCTGGAGAAGTAGCTCTGGCTTGTCTTCTTTTTCATTAAAGATAATTTATGTATCGACTAAGAAATAATAAGGTACATTCA
GATGTGGAAAACCCACCTTGGGACACCTTGACTCCAAGCCCAGCAGTAAGTCCAACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTG
ATGAGCAGCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGTGAAGTTGGCCCGACACATCCTGA
CTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGACTCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGA
AGGTTTTGAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCTTGTCATGGAGTACGCTAGTGGCG
GAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGATGAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGT
ACTGTCACCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATATGAACATCAAGATTGCAGACTTTG
GCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGACACCTTCTGTGGCAGTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAA
AATATGATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTATACACTGGTCAGCGGATCCCTGCCTTTTGATGGACAGAACC
TCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAATACCGTATTCCATTCTACATGTCCACGGACTGTGAAAACCTGCTTAAGAAATTTC
TCATTCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGTGGGTCACGAAGATGATGAACTAAAGC
CTTACGTGGAGCCACTCCCTGACTACAAGGACCCCCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAGATCCAGGACT
CGCTGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCTACAAGAGCTCCGAGCTGGAAGGCGACACCATCACCC
TGAAACCCCGGCCTTCAGCTGATCTGACCAATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC
AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTAAGAAGACTCAGAGTAACAACGCAGAAAATA
AGCGGCCTGAGGAGGACCGGGAGTCAGGGCGGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCCCCTGCCCGGTCTGGAGAGGAAGA
AGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGGAATTCCCCACTTTTGGAGCGGGCCAGCCTCG
GCCAGGCCTCCATCCAGAATGGCAAAGACAGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGTG
GTGGAGCCCCAGACCGAACTAACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCATGCTGGGCAGCTCCGACAGGTGCGGGACCAGC
AGAATTTGCCCTACGGTGTGACCCCAGCCTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAGCATCTTCAGCAAGTTCA
CCTCCAAGTTTGTACGCAGAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATGAACCTGAAAGCAAAGACCGAGTGGAGACGCTCA
GACCTCACGTGGTGGGCAGTGGCGGCAACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGAGTA
TGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGCTGGACGCGAACAGCTGCCAGAGCGAGCTGCATG
AGAAGTACATGCTGCTGTGCATGCACGGCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGCTCT
CTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACATTGCCTCCAAAATAGCCAACGAGCTGAAGCTTT
AACAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCAGCG
ATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGT
TCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATGGGGGG
GCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAA
ATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAAC
ACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAG
CAAACCACCAGAGGTGGCCTTCCCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCC
TGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGC
CCCTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCCCACCCCTC
CCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGG
GCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCCTCTCCCCA
TGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGTGACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTT
TCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGT
CTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCG
CTTGGCTGGTGGTGGCCACTGCATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGC
TGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGA
TGACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCTTGCCAACC
TCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGG
GTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCCTCCCCGTCTAG

>31380_31380_6_FRMD8-MARK2_FRMD8_chr11_65154592_ENST00000531296_MARK2_chr11_63662631_ENST00000413835_length(amino acids)=714AA_BP=
MGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP
NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF
TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPS
KRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPS
ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTP
STNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYG
VTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FRMD8-MARK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FRMD8-MARK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FRMD8-MARK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource