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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FRMD8-PACS1 (FusionGDB2 ID:31383)

Fusion Gene Summary for FRMD8-PACS1

Fusion gene summary

Fusion gene information	Fusion gene name: FRMD8-PACS1
	Fusion gene ID: 31383
		Hgene	Tgene
	Gene symbol	FRMD8	PACS1
	Gene ID	83786	55690
	Gene name	FERM domain containing 8	phosphofurin acidic cluster sorting protein 1
	Synonyms	FKSG44\|iTAP	MRD17\|SHMS
	Cytomap	11q13.1	11q13.1-q13.2
	Type of gene	protein-coding	protein-coding
	Description	FERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Protein	phosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1
	Modification date	20200313	20200313
	UniProtAcc	Q9BZ67	.
	Ensembl transtripts involved in fusion gene	ENST00000317568, ENST00000355991, ENST00000416776, ENST00000531296,	ENST00000524815, ENST00000529757, ENST00000320580,
Fusion gene scores	* DoF score	11 X 8 X 8=704	21 X 18 X 12=4536
	# samples	16	26
	** MAII score	log2(16/704*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/4536*10)=-4.12483711191377 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FRMD8 [Title/Abstract] AND PACS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FRMD8(65167330)-PACS1(65977833), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FRMD8	GO:1904469	positive regulation of tumor necrosis factor secretion	29897333

Fusion gene breakpoints across FRMD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PACS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8276-01A	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+

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Fusion Gene ORF analysis for FRMD8-PACS1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000317568	ENST00000524815	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
5CDS-intron	ENST00000317568	ENST00000529757	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
5CDS-intron	ENST00000355991	ENST00000524815	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
5CDS-intron	ENST00000355991	ENST00000529757	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
5CDS-intron	ENST00000416776	ENST00000524815	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
5CDS-intron	ENST00000416776	ENST00000529757	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
In-frame	ENST00000317568	ENST00000320580	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
In-frame	ENST00000355991	ENST00000320580	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
In-frame	ENST00000416776	ENST00000320580	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
intron-3CDS	ENST00000531296	ENST00000320580	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
intron-intron	ENST00000531296	ENST00000524815	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+
intron-intron	ENST00000531296	ENST00000529757	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000317568

FRMD8

chr11

65167330

ENST00000320580

PACS1

chr11

65977833

5005

1090

127

3537

1136

ENST00000355991

FRMD8

chr11

65167330

ENST00000320580

PACS1

chr11

65977833

4799

884

3331

1080

ENST00000416776

FRMD8

chr11

65167330

ENST00000320580

PACS1

chr11

65977833

4845

930

3377

1102

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000317568	ENST00000320580	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+	0.001920548	0.9980794
ENST00000355991	ENST00000320580	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+	0.001827689	0.9981723
ENST00000416776	ENST00000320580	FRMD8	chr11	65167330	+	PACS1	chr11	65977833	+	0.00175324	0.9982468

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Fusion Genomic Features for FRMD8-PACS1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FRMD8	chr11	65167330	+	PACS1	chr11	65977832	+	0.001010581	0.9989894
FRMD8	chr11	65167330	+	PACS1	chr11	65977832	+	0.001010581	0.9989894

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FRMD8-PACS1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65167330/chr11:65977833)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FRMD8 Q9BZ67	.
FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269\|PubMed:19572019, ECO:0000269\|PubMed:29897333, ECO:0000269\|PubMed:29897336}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

353_377

148

964.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

279_283

148

964.0

Compositional bias

Note=Poly-Glu

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

168_175

148

964.0

Region

Note=Involved in binding to AP-1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FRMD8

chr11:65167330

chr11:65977833

ENST00000317568

30_376

309

465.0

Domain

FERM

Hgene

FRMD8

chr11:65167330

chr11:65977833

ENST00000355991

30_376

253

409.0

Domain

FERM

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

112_115

148

964.0

Compositional bias

Note=Poly-Ser

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

35_40

148

964.0

Compositional bias

Note=Poly-Gln

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

55_84

148

964.0

Compositional bias

Note=Ser-rich

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

5_44

148

964.0

Compositional bias

Note=Gly-rich

Tgene

PACS1

chr11:65167330

chr11:65977833

ENST00000320580

62_65

148

964.0

Compositional bias

Note=Poly-Ala

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Fusion Gene Sequence for FRMD8-PACS1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>31383_31383_1_FRMD8-PACS1_FRMD8_chr11_65167330_ENST00000317568_PACS1_chr11_65977833_ENST00000320580_length(transcript)=5005nt_BP=1090nt
GCCTCGGGCGCCGCGCTTCCTCCCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGG
CGGGCTTGGCGGCGGGGCAGGATTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGATGGACGGGACAGAAGG
CAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACCGAAGCAGCGTGTCCTCCGTGGGAGCCCGAGCGGCTGACGTGCTGGTATACCT
AGCGGATGACACGGTGGTGCCCCTGGCTGTGGAGAACCTGCCCTCGCTCAGTGCCCATGAGCTGCACCGCGCTGTCCGCGAGGTCCTGCA
GCTTCCAGACATCGCCCTGGATGTCTTCGCGCTCTGGCTGGTCTCCCCTCTGCTGGAGGTGCAGCTGAAACCCAAGCACCAGCCCTACAA
GCTGGGACGCCAGTGGCCGGAGCTGCTGCTGCGCTTCACCAGTGCCCCAGACGATGACGTGGCCATGGATGAGCCTTTCCTGCAGTTCCG
AAGGAACGTGTTCTTCCCAAAGCGGCGGGAGCTCCAGATCCATGACGAGGAGGTCCTGCGGCTGCTCTATGAGGAGGCCAAGGGCAACGT
GCTGGCTGCACGGTACCCGTGCGACGTGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAGCTTGGGCCCTACCAGCCCGG
CCGGCCGGCAGCCTGCGACCTGAGGGAGAAGCTGGACTCCTTCCTCCCTGCCCACCTCTGTAAGCGGGGCCAGAGTCTCTTTGCTGCCCT
CCGGGGCCGTGGGGCCAGGGCCGGGCCGGGCGAGCAGGGCCTGCTGAACGCCTACCGCCAGGTGCAGGAGGTCAGCAGCGACGGCGGGTG
CGAGGCCGCCCTGGGCACCCACTACCGCGCCTATCTCCTCAAGTGCCACGAGCTGCCGTTTTATGGGTGTGCCTTCTTCCACGGTGAGGT
TGACAAGCCGGCCCAAGGCTTTTTGCACCGGGGTGGGCGCAAGCCAGTTTCTGTGGCCATCAGTCTGGAAGGCGTGCACGTCATCGATAG
CAGAGAGAAGGGTTCAAAAAGAATTCTTCGCTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAAACAGAGCTCCAATTAACCTT
CTCCCTTCAGTACCCTCATTTCCTTAAGCGAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAACGTTACAAGAATCGGACCAT
CTTGGGCTATAAGACCTTGGCCGTGGGACTCATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGCGCACTGGTGCTTGGCCTACA
CAGCAACGTGAAGGATGTCTCTGTGCCTGTGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATTGACCATGAAGGAATCAAATC
CAAGCTTTCTGATCGTTCTCCTGATATTGACAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAACAGGAAGGCAGTGATGATCC
ATTGCATGGGCAGGACTTGTTCTACGAAGACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTAACCTCAACCTCTGCCATCAC
AAGGCAACCTAACATCAAACAGAAGTTTGTGGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGCTTTGGGCTGGAGCATGTGTC
CCGCGAGCAGATCCGGGAAGTGGAAGAGGACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCCAGCGACAGTGGCCCTGAGAT
GGAGGAGACAGAAAGCATCCTCAGCACGCCAAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAGTCCAGCTCCCAGACGGAGAT
TGGCAGCCTCAACAGCAAAGGCAGCCTCGGAAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAAAAAATTAAATCTACTTGGAT
TAAAAACCAAGATGACAGCTTGACTGAAACAGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGATGCCAGCACGAGTCTGGTTGT
GCCGGAGAAAGTCAAAACTCCCATGAAGTCCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAAGTGGAGGGGGTGCACACACC
CCGGCAGAAGAGGAGCACGCCCCTGAAGGAGCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGTTCCGACAGCGAGCGCTCCCC
AGATCTGGGCCACAGCACGCAGATTCCAAGAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCAGATGCAGCCCTCCCAGAAAA
TGTCATTCTGGTGAACACCACTGACTGGCAGGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAGCCTGTGGTGTGCACCTGCTC
CACCGTGGAGGTCCAGGCCGTGCTGTCCGCCCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCTTCCATGCCGAGGCCAGTGAA
GGTGGCTGCTGTGGGAGGCCAGAGCTACCTGAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAACAAGACCTCCGACTGGCTTGG
CTACATGCGCTTCCTCATCATCCCCCTCGGTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGTAAATACAGTAGTTCCTTCCT
GGATTCTGGTTGGAGAGATCTGTTCAGTCGCTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGGCGGGTGATGCAGTACGTCAA
CGGGGCAGCCACGACACACCAGCTTCCCGTGGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGATGAAGACTCCTATCAGAAGTT
TATTCCCTTCATTGGCGTGGTGAAGGTGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCT
TACTGTGCCCTCCACATCACCACCCTCCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGC
CCTGGCCATCGTGGGGAGCCCTAATAGCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAG
GAGGGAAGGCGACAAGAGGGACGCCAGCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGG
GGAGGCCCAGCTTTCTGGCACCATGGCCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACC
CCGAGAAAAGGAGGTGGATTCTAAGAGCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAG
AGTGTCCATCGATGGGGTCGAGTGGAGTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGG
ACTCTTCAGTGGCAGCAAGGCCACCTGAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAG
GGGGAGGCCAGCAGGCCCGGGCCCAGCACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAG
GGACGCCTTCCCTCCCCTCCCCTCCAGCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCA
AGGCGTGTTGGTTTTGCCTTCTGGTGCCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGT
GGTATCAGTTTCCTTCTCGGAAATGAGAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAG
GGTGTCCTCTAGGATGCAGCTGCCAGATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCA
CCTGCCCCAGAGCTTCTCAAGGGAGGGTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTC
CCCTGCCTCCAGGACCCTGTTGCTATGGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTT
CCTCACCACCCCCAGGTTCCCTGCAGATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATG
TGACACACCCTGTGCACTGGTCGCTGTCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCA
CAGCTCTGCCTGGACTTGGAGAGATGGGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCC
ATTCATCTCCCTCCTCCCACCGTGTCAGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCC
ATCCTCCCAGCCAGGTTTCCCTCCAGCAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGA
CCGTCCGTGTTCTCAGGAGTGGTTGAGGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCC
TTTGGAGCTTTTCTCTTGTCCTCTCACTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCT
CCCCCAAGCTCTCCTCCAGCCCTTCCCAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGG

>31383_31383_1_FRMD8-PACS1_FRMD8_chr11_65167330_ENST00000317568_PACS1_chr11_65977833_ENST00000320580_length(amino acids)=1136AA_BP=321
MPLRWRALRPCEMDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRAVREVLQLPDIALDVFALW
LVSPLLEVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDEPFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDC
EALGALVCRVQLGPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYL
LKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVSVAISLEGVHVIDSREKGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDA
NKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNY
SEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLD
ELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDT
LEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQGSASPSKVEGVHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKV
VYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSS
ILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAKYLGSVDSKYSSSFLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAE
AMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYG
DVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVI

--------------------------------------------------------------
>31383_31383_2_FRMD8-PACS1_FRMD8_chr11_65167330_ENST00000355991_PACS1_chr11_65977833_ENST00000320580_length(transcript)=4799nt_BP=884nt
GTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGATTCCAGGCAGGAGCCT
TGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGATGGACGGGACAGAAGGCAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACC
GAAGCAGCGTGTCCTCCGTGGGAGCCCGAGAGGTGCAGCTGAAACCCAAGCACCAGCCCTACAAGCTGGGACGCCAGTGGCCGGAGCTGC
TGCTGCGCTTCACCAGTGCCCCAGACGATGACGTGGCCATGGATGAGCCTTTCCTGCAGTTCCGAAGGAACGTGTTCTTCCCAAAGCGGC
GGGAGCTCCAGATCCATGACGAGGAGGTCCTGCGGCTGCTCTATGAGGAGGCCAAGGGCAACGTGCTGGCTGCACGGTACCCGTGCGACG
TGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAGCTTGGGCCCTACCAGCCCGGCCGGCCGGCAGCCTGCGACCTGAGGG
AGAAGCTGGACTCCTTCCTCCCTGCCCACCTCTGTAAGCGGGGCCAGAGTCTCTTTGCTGCCCTCCGGGGCCGTGGGGCCAGGGCCGGGC
CGGGCGAGCAGGGCCTGCTGAACGCCTACCGCCAGGTGCAGGAGGTCAGCAGCGACGGCGGGTGCGAGGCCGCCCTGGGCACCCACTACC
GCGCCTATCTCCTCAAGTGCCACGAGCTGCCGTTTTATGGGTGTGCCTTCTTCCACGGTGAGGTTGACAAGCCGGCCCAAGGCTTTTTGC
ACCGGGGTGGGCGCAAGCCAGTTTCTGTGGCCATCAGTCTGGAAGGCGTGCACGTCATCGATAGCAGAGAGAAGGGTTCAAAAAGAATTC
TTCGCTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAAACAGAGCTCCAATTAACCTTCTCCCTTCAGTACCCTCATTTCCTTA
AGCGAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAACGTTACAAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGG
GACTCATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGCGCACTGGTGCTTGGCCTACACAGCAACGTGAAGGATGTCTCTGTGC
CTGTGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATTGACCATGAAGGAATCAAATCCAAGCTTTCTGATCGTTCTCCTGATA
TTGACAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAACAGGAAGGCAGTGATGATCCATTGCATGGGCAGGACTTGTTCTACG
AAGACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTAACCTCAACCTCTGCCATCACAAGGCAACCTAACATCAAACAGAAGT
TTGTGGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGCTTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGGGAAGTGGAAG
AGGACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCCAGCGACAGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCA
CGCCAAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAGTCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGCAAAGGCAGCC
TCGGAAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAAAAAATTAAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTG
AAACAGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGATGCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAAACTCCCATGA
AGTCCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAAGTGGAGGGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGA
AGGAGCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGTTCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGCACGCAGATTC
CAAGAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCAGATGCAGCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACT
GGCAGGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAGCCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAGGCCGTGCTGT
CCGCCCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCTTCCATGCCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCT
ACCTGAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAACAAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTCATCATCCCCC
TCGGTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGTAAATACAGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCA
GTCGCTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGGCGGGTGATGCAGTACGTCAACGGGGCAGCCACGACACACCAGCTTC
CCGTGGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGATGAAGACTCCTATCAGAAGTTTATTCCCTTCATTGGCGTGGTGAAGG
TGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCT
CCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATA
GCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCA
GCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGG
CCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGA
GCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGA
GTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCT
GAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAG
CACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCA
GCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTG
CCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGA
GAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAG
ATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGG
GTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTAT
GGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAG
ATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTG
TCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATG
GGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTC
AGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAG
CAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGA
GGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCA
CTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCC
CAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGGACTGAGTTGATGTTGGGTTTTTCATT

>31383_31383_2_FRMD8-PACS1_FRMD8_chr11_65167330_ENST00000355991_PACS1_chr11_65977833_ENST00000320580_length(amino acids)=1080AA_BP=265
MPLRWRALRPCEMDGTEGSAGQPGPAERSHRSSVSSVGAREVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDEPFLQFRRNVFFPKR
RELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAG
PGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVSVAISLEGVHVIDSREKGSKRI
LRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSV
PVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQK
FVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGS
LGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQGSASPSKVEGVHTPRQKRSTPL
KERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVL
SALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAKYLGSVDSKYSSSFLDSGWRDLF
SRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPP
SSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHSGEAQLSGTM
AMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKAT

--------------------------------------------------------------
>31383_31383_3_FRMD8-PACS1_FRMD8_chr11_65167330_ENST00000416776_PACS1_chr11_65977833_ENST00000320580_length(transcript)=4845nt_BP=930nt
GTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGATTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCT
CTGCGACCCTGCGAGATGGACGGGACAGAAGGCAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACCGAAGCAGCGTGTCCTCCGTG
GGAGCCCGAGCGGCTGACGTGCTGGTATACCTAGCGGATGACACGGTGGTGCCCCTGGCTGTGGAGAACCTGCCCTCGCTCAGTGCCCAT
GAGCTGCACCGCGCTGTCCGCGAGGTCCTGCAGCTTCCAGACATCGCCCTGGATGTCTTCGCGCTCTGGCTGGTCTCCCCTCTGCTGGAT
GAGCCTTTCCTGCAGTTCCGAAGGAACGTGTTCTTCCCAAAGCGGCGGGAGCTCCAGATCCATGACGAGGAGGTCCTGCGGCTGCTCTAT
GAGGAGGCCAAGGGCAACGTGCTGGCTGCACGGTACCCGTGCGACGTGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAG
CTTGGGCCCTACCAGCCCGGCCGGCCGGCAGCCTGCGACCTGAGGGAGAAGCTGGACTCCTTCCTCCCTGCCCACCTCTGTAAGCGGGGC
CAGAGTCTCTTTGCTGCCCTCCGGGGCCGTGGGGCCAGGGCCGGGCCGGGCGAGCAGGGCCTGCTGAACGCCTACCGCCAGGTGCAGGAG
GTCAGCAGCGACGGCGGGTGCGAGGCCGCCCTGGGCACCCACTACCGCGCCTATCTCCTCAAGTGCCACGAGCTGCCGTTTTATGGGTGT
GCCTTCTTCCACGGTGAGGTTGACAAGCCGGCCCAAGGCTTTTTGCACCGGGGTGGGCGCAAGCCAGTTTCTGTGGCCATCAGTCTGGAA
GGCGTGCACGTCATCGATAGCAGAGAGAAGGGTTCAAAAAGAATTCTTCGCTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAA
ACAGAGCTCCAATTAACCTTCTCCCTTCAGTACCCTCATTTCCTTAAGCGAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAA
CGTTACAAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGGGACTCATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGC
GCACTGGTGCTTGGCCTACACAGCAACGTGAAGGATGTCTCTGTGCCTGTGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATT
GACCATGAAGGAATCAAATCCAAGCTTTCTGATCGTTCTCCTGATATTGACAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAA
CAGGAAGGCAGTGATGATCCATTGCATGGGCAGGACTTGTTCTACGAAGACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTA
ACCTCAACCTCTGCCATCACAAGGCAACCTAACATCAAACAGAAGTTTGTGGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGC
TTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGGGAAGTGGAAGAGGACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCC
AGCGACAGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCACGCCAAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAG
TCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGCAAAGGCAGCCTCGGAAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAA
AAAATTAAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTGAAACAGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGAT
GCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAAACTCCCATGAAGTCCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAA
GTGGAGGGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGAAGGAGCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGT
TCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGCACGCAGATTCCAAGAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCA
GATGCAGCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACTGGCAGGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAG
CCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAGGCCGTGCTGTCCGCCCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCT
TCCATGCCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCTACCTGAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAAC
AAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTCATCATCCCCCTCGGTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGT
AAATACAGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCAGTCGCTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGG
CGGGTGATGCAGTACGTCAACGGGGCAGCCACGACACACCAGCTTCCCGTGGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGAT
GAAGACTCCTATCAGAAGTTTATTCCCTTCATTGGCGTGGTGAAGGTGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGAC
GATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCTCCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCC
TCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATAGCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTG
GGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCAGCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTG
TCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGGCCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACC
ATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGAGCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAG
CAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGAGTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCAT
GTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCTGAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCA
GCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAGCACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGT
CCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCAGCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTC
TCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTGCCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCG
ACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGAGAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCC
CCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAGATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTC
AACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGGGTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTC
ACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTATGGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCC
CCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAGATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCA
AGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTGTCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCC
TCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATGGGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCA
GACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTCAGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGC
CCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAGCAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGG
TCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGAGGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGC
CATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCACTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGT
TTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCCCAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAG

>31383_31383_3_FRMD8-PACS1_FRMD8_chr11_65167330_ENST00000416776_PACS1_chr11_65977833_ENST00000320580_length(amino acids)=1102AA_BP=287
MPLRWRALRPCEMDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRAVREVLQLPDIALDVFALW
LVSPLLDEPFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLREKLDSFLP
AHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPV
SVAISLEGVHVIDSREKGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEV
MQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKV
KKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKP
FFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQ
GSASPSKVEGVHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAE
LLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAK
YLGSVDSKYSSSFLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSP
STAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKS
VFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FRMD8-PACS1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FRMD8-PACS1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FRMD8-PACS1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source