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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FRS2-DTX3 (FusionGDB2 ID:31429)

Fusion Gene Summary for FRS2-DTX3

check button Fusion gene summary
Fusion gene informationFusion gene name: FRS2-DTX3
Fusion gene ID: 31429
HgeneTgene
Gene symbol

FRS2

DTX3

Gene ID

10818

196403

Gene namefibroblast growth factor receptor substrate 2deltex E3 ubiquitin ligase 3
SynonymsFRS1A|FRS2A|FRS2alpha|SNT|SNT-1|SNT1RNF154|deltex3
Cytomap

12q15

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTepididymis secretory sperm binding proteinsuc1-associated neurotrophic factor target 1probable E3 ubiquitin-protein ligase DTX3RING finger protein 154RING-type E3 ubiquitin transferase DTX3deltex 3, E3 ubiquitin ligasedeltex homolog 3protein deltex-3
Modification date2020031320200313
UniProtAcc.

Q8TDB6

Ensembl transtripts involved in fusion geneENST00000299293, ENST00000549921, 
ENST00000550389, ENST00000397997, 
ENST00000337737, ENST00000548198, 
ENST00000548804, ENST00000551632, 
Fusion gene scores* DoF score71 X 15 X 14=149105 X 6 X 4=120
# samples 737
** MAII scorelog2(73/14910*10)=-4.35223998340343
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRS2 [Title/Abstract] AND DTX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRS2(69864310)-DTX3(58002860), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FRS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DTX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-3653-01AFRS2chr12

69864310

+DTX3chr12

58002860

+
ChimerDB4GBMTCGA-12-3653FRS2chr12

69864310

+DTX3chr12

58002859

+
ChimerDB4GBMTCGA-41-2571-01AFRS2chr12

69864310

-DTX3chr12

58002303

+
ChimerDB4GBMTCGA-41-2571-01AFRS2chr12

69864310

+DTX3chr12

58002303

+
ChimerDB4GBMTCGA-41-2571-01AFRS2chr12

69864310

+DTX3chr12

58002860

+
ChimerDB4GBMTCGA-41-2571FRS2chr12

69864310

+DTX3chr12

58002302

+
ChimerDB4GBMTCGA-41-2571FRS2chr12

69864310

+DTX3chr12

58002859

+
ChimerDB4GBMTCGA-41-2571FRS2chr12

69874139

+DTX3chr12

58002302

+
ChimerDB4GBMTCGA-41-2571FRS2chr12

69874139

+DTX3chr12

58002859

+


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Fusion Gene ORF analysis for FRS2-DTX3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000299293ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000299293ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000299293ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000299293ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000299293ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000299293ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000299293ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000299293ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000299293ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000299293ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000299293ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000299293ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000299293ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000299293ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000299293ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000299293ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000549921ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000549921ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000549921ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000549921ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000549921ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000549921ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000549921ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000549921ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000549921ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000549921ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000549921ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000549921ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000549921ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000549921ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000549921ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000549921ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000550389ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000550389ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000550389ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000550389ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000550389ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000550389ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000550389ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000550389ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000550389ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000550389ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000550389ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000550389ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002859

+
5UTR-3CDSENST00000550389ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002860

+
5UTR-3CDSENST00000550389ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002303

+
5UTR-3CDSENST00000550389ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002302

+
5UTR-3CDSENST00000550389ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002859

+
intron-3CDSENST00000299293ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000299293ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000299293ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000299293ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000299293ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000299293ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000299293ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000299293ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002860

+
intron-3CDSENST00000397997ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002303

+
intron-3CDSENST00000397997ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000337737FRS2chr12

69864310

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002860

+
intron-3CDSENST00000397997ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002303

+
intron-3CDSENST00000397997ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000548198FRS2chr12

69864310

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002860

+
intron-3CDSENST00000397997ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002303

+
intron-3CDSENST00000397997ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000548804FRS2chr12

69864310

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002860

+
intron-3CDSENST00000397997ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002303

+
intron-3CDSENST00000397997ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000551632FRS2chr12

69864310

+DTX3chr12

58002859

+
intron-3CDSENST00000397997ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000397997ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000549921ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000549921ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000549921ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000549921ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000549921ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000549921ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000549921ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000549921ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000550389ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000550389ENST00000337737FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000550389ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000550389ENST00000548198FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000550389ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000550389ENST00000548804FRS2chr12

69874139

+DTX3chr12

58002859

+
intron-3CDSENST00000550389ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002302

+
intron-3CDSENST00000550389ENST00000551632FRS2chr12

69874139

+DTX3chr12

58002859

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FRS2-DTX3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FRS2chr1269864310+DTX3chr1258002859+0.002983860.9970162
FRS2chr1269864310+DTX3chr1258002859+0.002983860.9970162
FRS2chr1269864310+DTX3chr1258002302+3.19E-050.99996805
FRS2chr1269864310+DTX3chr1258002302+3.19E-050.99996805
FRS2chr1269864310+DTX3chr1258002859+0.002983860.9970162
FRS2chr1269864310+DTX3chr1258002859+0.002983860.9970162
FRS2chr1269864310+DTX3chr1258002302+3.19E-050.99996805
FRS2chr1269864310+DTX3chr1258002302+3.19E-050.99996805

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FRS2-DTX3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69864310/:58002860)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DTX3

Q8TDB6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FRS2-DTX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FRS2-DTX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FRS2-DTX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FRS2-DTX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource