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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AHSA1-TMEM67 (FusionGDB2 ID:3145)

Fusion Gene Summary for AHSA1-TMEM67

Fusion gene summary

Fusion gene information	Fusion gene name: AHSA1-TMEM67
	Fusion gene ID: 3145
		Hgene	Tgene
	Gene symbol	AHSA1	TMEM67
	Gene ID	10598	91147
	Gene name	activator of HSP90 ATPase activity 1	transmembrane protein 67
	Synonyms	AHA1\|C14orf3\|hAha1\|p38	JBTS6\|MECKELIN\|MKS3\|NPHP11\|TNEM67
	Cytomap	14q24.3	8q22.1
	Type of gene	protein-coding	protein-coding
	Description	activator of 90 kDa heat shock protein ATPase homolog 1AHA1, activator of heat shock 90kDa protein ATPase homolog 1	meckelinmeckel syndrome type 3 protein
	Modification date	20200313	20200313
	UniProtAcc	O95433	.
	Ensembl transtripts involved in fusion gene	ENST00000216479, ENST00000535854, ENST00000555457, ENST00000555517,	ENST00000409623, ENST00000425545, ENST00000453321,
Fusion gene scores	* DoF score	2 X 2 X 2=8	4 X 7 X 4=112
	# samples	2	5
	** MAII score	log2(2/8*10)=1.32192809488736	log2(5/112*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AHSA1 [Title/Abstract] AND TMEM67 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AHSA1(77931029)-TMEM67(94770711), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AHSA1	GO:0032781	positive regulation of ATPase activity	29127155

Fusion gene breakpoints across AHSA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMEM67 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7212-01A	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+

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Fusion Gene ORF analysis for AHSA1-TMEM67

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000216479	ENST00000409623	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
5CDS-5UTR	ENST00000535854	ENST00000409623	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
5CDS-intron	ENST00000216479	ENST00000425545	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
5CDS-intron	ENST00000535854	ENST00000425545	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
In-frame	ENST00000216479	ENST00000453321	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
In-frame	ENST00000535854	ENST00000453321	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
intron-3CDS	ENST00000555457	ENST00000453321	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
intron-3CDS	ENST00000555517	ENST00000453321	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
intron-5UTR	ENST00000555457	ENST00000409623	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
intron-5UTR	ENST00000555517	ENST00000409623	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
intron-intron	ENST00000555457	ENST00000425545	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+
intron-intron	ENST00000555517	ENST00000425545	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000216479

AHSA1

chr14

77931029

ENST00000453321

TMEM67

chr8

94770711

5002

721

160

3396

1078

ENST00000535854

AHSA1

chr14

77931029

ENST00000453321

TMEM67

chr8

94770711

5000

719

158

3394

1078

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216479	ENST00000453321	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+	7.43E-05	0.99992573
ENST00000535854	ENST00000453321	AHSA1	chr14	77931029	+	TMEM67	chr8	94770711	+	7.44E-05	0.9999256

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Fusion Genomic Features for AHSA1-TMEM67

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AHSA1	chr14	77931029	+	TMEM67	chr8	94770714	+	2.45E-07	0.99999976
AHSA1	chr14	77931029	+	TMEM67	chr8	94770714	+	2.45E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AHSA1-TMEM67

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:77931029/chr8:94770711)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AHSA1 O95433	.
FUNCTION: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). {ECO:0000269\|PubMed:27353360, ECO:0000269\|PubMed:29127155}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000409623

526_546

915.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000409623

570_590

915.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000409623

609_629

915.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000409623

689_709

915.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000409623

734_754

915.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000409623

939_959

915.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000453321

526_546

104

996.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000453321

570_590

104

996.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000453321

609_629

104

996.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000453321

689_709

104

996.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000453321

734_754

104

996.0

Transmembrane

Helical

Tgene

TMEM67

chr14:77931029

chr8:94770711

ENST00000453321

939_959

104

996.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for AHSA1-TMEM67

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>3145_3145_1_AHSA1-TMEM67_AHSA1_chr14_77931029_ENST00000216479_TMEM67_chr8_94770711_ENST00000453321_length(transcript)=5002nt_BP=721nt
GGAAGTTAAGGAGGGGAGGGGGTGGAGGGAAAAGCAAGCCAGGAGGTGCTTGCGGCCGCTTCTAGTAGTTTCCAGGCGCTGCCGGGCGGC
TGGCACTAAGCGGTCCTGAGGCTGTGGCTACGGCTGCTCCGGAGCTGGTGGCGCCGCGATAGGAGAGCCGATGGCCAAGTGGGGTGAGGG
AGACCCACGCTGGATCGTGGAGGAGCGGGCGGACGCCACCAACGTCAACAACTGGCACTGGACGGAGAGAGATGCTTCAAATTGGTCCAC
GGATAAGCTGAAAACACTGTTCCTGGCAGTGCAGGTTCAAAATGAAGAAGGCAAGTGTGAGGTGACGGAAGTGAGTAAGCTTGATGGAGA
GGCATCCATTAACAATCGCAAAGGGAAACTTATCTTCTTTTATGAATGGAGCGTCAAACTAAACTGGACAGGTACTTCTAAGTCAGGAGT
ACAATACAAAGGACATGTGGAGATCCCCAATTTGTCTGATGAAAACAGCGTGGATGAAGTGGAGATTAGTGTGAGCCTTGCCAAAGATGA
GCCTGACACAAATCTCGTGGCCTTAATGAAGGAAGAAGGGGTGAAACTTCTAAGAGAAGCAATGGGAATTTACATCAGCACCCTCAAAAC
AGAGTTCACCCAGGGCATGATCTTACCTACAATGAATGGAGAGTCAGTAGACCCAGTGGGGCAGCCAGCACTGAAAACTGAGGAGCGCAA
GAAAGGTGTTACAGAAGATGGCTGGAACTGCATTTCTTGCCCTAGTGACTTAACTGCCGAAGGAAAATGTCACTGTCCCATTGGCCATAT
TTTAGTGGAAAGAGACATTAATGGAACATTGTTGTCTCAAGCAACTTGTGAGCTCTGTGATGGAAATGAAAACTCTTTTATGGTAGTAAA
TGCTTTAGGAGACAGGTGCGTCCGATGTGAGCCAACATTTGTTAATACCAGCAGGTCCTGTGCATGTTCAGAACCTAACATTTTAACAGG
GGGATTATGTTTCAGCAGCACAGGGAATTTTCCTCTACGTAGAATTTCAGCTGCACGTTATGGAGAAGTTGGCATGTCTTTAACTTCAGA
ATGGTTTGCAAAGTATTTGCAATCATCAGCAGCTGCATGTTGGGTATATGCCAATCTAACATCTTGTCAAGCTCTTGGAAATATGTGTGT
GATGAACATGAATTCTTACGACTTTGCCACATTTGATGCATGTGGACTATTTCAGTTTATCTTTGAAAATACTGCTGGACTGAGCACTGT
TCATTCTATTTCATTTTGGAGACAGAATCTTCCTTGGCTGTTTTATGGAGACCAGTTAGGATTAGCACCTCAAGTGCTCAGTTCTACCTC
TCTTCCTACAAATTTCAGTTTTAAAGGAGAAAACCAGAATACAAAACTGAAGTTTGTTGCTGCTTCCTATGATATAAGAGGAAATTTTCT
CAAGTGGCAAACTTTAGAAGGAGGTGTTTTACAGCTTTGTCCAGACACAGAGACAAGGCTAAATGCTGCTTATTCATTTGGAACAACCTA
CCAACAAAATTGTGAGATTCCTATCTCTAAGATCTTAATTGACTTTCCCACTCCTATATTTTATGATGTGTACCTTGAATATACTGATGA
AAATCAACATCAATATATTTTGGCTGTGCCTGTGTTAAACCTAAATCTTCAACATAATAAGATATTTGTGAACCAAGACAGCAACTCTGG
AAAGTGGCTTCTAACTCGGCGCATTTTCTTAGTGGATGCAGTAAGTGGACGAGAAAATGACTTAGGAACTCAGCCAAGAGTAATTCGAGT
TGCTACTCAAATATCACTGAGTGTCCACCTTGTACCCAACACAATAAATGGAAACATCTACCCTCCCTTAATCACCATTGCCTACAGTGA
CATTGATATCAAAGATGCCAACAGCCAGTCTGTGAAGGTTTCTTTCTCAGTCACATATGAAATGGATCATGGAGAAGCACATGTCCAGAC
AGATATTGCTTTGGGTGTATTGGGTGGGCTAGCTGTTTTAGCATCTCTTTTGAAGACAGCAGGATGGAAGAGGCGCATTGGGAGTCCCAT
GATTGATTTACAGACAGTTGTGAAATTCTTGGTGTACTATGCTGGTGATCTGGCCAATGTTTTCTTTATCATCACAGTGGGAACAGGTCT
TTACTGGCTTATTTTCTTCAAAGCACAGAAGTCTGTGTCTGTTTTGCTGCCAATGCCAATTCAGGAAGAACGTTTTGTCACTTATGTTGG
ATGTGCCTTTGCTCTGAAGGCACTACAATTTTTGCATAAGCTCATATCCCAGATTACAATAGATGTATTCTTTATTGATTGGGAGCGACC
TAAAGGAAAGGTTCTTAAAGCTGTTGAAGGTGAGGGTGGTGTACGAAGTGCCACTGTTCCTGTAAGCATATGGAGAACATATTTTGTAGC
AAATGAATGGAATGAAATTCAGACTGTGAGAAAAATTAATTCACTCTTTCAAGTACTTACTGTCCTCTTCTTTTTGGAGGTTGTGGGATT
CAAGAACTTAGCATTAATGGACTCATCTTCTAGTCTTTCTAGAAACCCACCTAGCTACATAGCTCCTTATAGCTGCATTTTGAGATATGC
AGTGTCTGCTGCTCTTTGGCTAGCCATTGGAATTATACAGGTCGTGTTCTTTGCTGTCTTTTATGAGAGATTTATAGAAGATAAAATTCG
ACAGTTCGTTGATTTATGCTCTATGAGTAATATATCAGTGTTTCTGTTATCCCACAAATGTTTTGGATATTACATTCATGGTAGATCAGT
ACATGGGCATGCAGATACTAATATGGAAGAAATGAATATGAACCTTAAAAGAGAAGCGGAAAATTTGTGTAGCCAGAGAGGTTTGGTACC
CAACACAGATGGTCAGACTTTTGAGATTGCAATTTCTAACCAGATGAGACAACATTATGACAGAATTCATGAGACACTAATAAGGAAAAA
TGGTCCTGCTAGACTACTGAGTTCATCAGCAAGTACTTTTGAGCAGAGTATAAAAGCATATCATATGATGAATAAATTTCTTGGCTCCTT
CATTGACCATGTTCATAAGGAAATGGATTACTTTATAAAAGATAAGTTGCTTCTTGAAAGAATTCTTGGAATGGAATTCATGGAACCAAT
GGAAAAAAGCATCTTTTACAATGATGAAGGTTATTCTTTCAGCAGTGTCCTGTATTATGGAAATGAAGCTACTCTTCTTATTTTTGATCT
GCTGTTCTTCTGTGTTGTGGATTTGGCTTGCCAAAATTTTATTTTAGCATCCTTCCTTACATATCTACAACAAGAGATTTTTAGATATAT
CCGTAATACAGTAGGACAAAAGAATTTGGCATCCAAAACATTGGTGGATCAAAGATTTTTGATTTAACTTCCTGAATAAATAACTTAAAG
ACTCAGTATAATCATGGCCAAAAAAAAGTCATGATATCAGGTTAGTTTGCCATATTTTTTAAAACTTATAATGCAGACTATTCTGTTTTT
GTTTTTTATTTGCAGAAAGATTTATTTTTATAACTTGGGAATATATAACCTGATATAATAGAAAATACTGTTTTCCCATTGTGTGTAGTA
TTTAATGCAGTAAATAATAAATTAATACTGACAGTGAGGCCAAAAAAAATCTAAATGTTGCTTTCAGCATAATACTTTTTAATGCTAATT
AAAACAGTCCCCATCATTTGTCTCTGTAGATTATTTTATAAACTGAGAGCTGCCTGAATCTTCTCACATTGACAAAGTAATTTGATTCCA
AGTTTAAGACTAGTTTTCAGTTTGATATTTTCATGTTTTGTGTGCTTATGGTTAAATAAATGTTGAAAGATATTTTCAAGTTTACTTAGA
AATTTTAAATTGTATTATTGCTGATTCAATTTGCATCATTCTAATTGCTCATCCTCTTTGGCAGTGGATTAATTCACTGTTGGGTTAATA
TGCATCTCATGAAATGATATCTTTTCATTCCTTTGTATACCTGTATTAGGTCAGTATACGCTTTCCATGAAATATATTTGCATTTCTAAT
ATAGTTTACATTTATTAAGTTATAACGTATGACATTTTTCCCAATATCATTTTTTATACATTTTAATTACTTAATGTTTTAAGAGTTCTC
TTCCAGAGTTTTGCTTTTCAATTACGTTTAAAGACTGTAAATAACAAACAGTAAGGCTGGGCGCTGTGGCTTACGCCTGTAATCCCAGCA
CTTTGGAAGGCCAAGGCACGTGGATCACTTTAGGTCAGGAGTTCAAGAACAGCCTGGCCAACATGGAAAACCCCATCTCTACAAAAAATA
CAAAAATTAGTTGGATGTGGTGGCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCATGAGAATAGCTTGAAACCAGGAGGTGGAGGCTGT
AGTGAGCCAGATAGCACCACTGCACTCCAGCCAGGATGACAGAGCAAGACCCTGTCTCAGAAAAAACAAAAACAAAACACTGTAAATGTA
TCATGTTTCTCACTGCTTTCTATGTTAATGCTGTGTAAATACTTAAAATGGAATACTGTATAAATATTATTTATATTTTCTCAGATGAAA
ATATATACTAAAACATTTGGTATTTCTGTTTTCTGTTTCATTAATGTATATCTGATGGAGTACCATTTAGGAATATAACATTATTGGGGC
AGAGGTCCCAGCCATTGCCAAAGTTGAATCTTTTACATTTCCCTGAATCTTGAGGATGACTGAAAAGGAAGTCTTTGAAACTGCAGTTTC
TGAAGGATCACAGTACAGGAATGCCTTTATAAAAGCTGCAGAGATAAATACATGTACTTATATGGCATGGATATTTAAAACCACTCACTC
AGAAGCATATGAAAGAAATTCAACCATCATTCAACATAGAAGAAGTTAATTTTAGTGCAAAAGTTTTTAAGTATTAAATTTCACAATAAA

>3145_3145_1_AHSA1-TMEM67_AHSA1_chr14_77931029_ENST00000216479_TMEM67_chr8_94770711_ENST00000453321_length(amino acids)=1078AA_BP=187
MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWT
GTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPA
LKTEERKKGVTEDGWNCISCPSDLTAEGKCHCPIGHILVERDINGTLLSQATCELCDGNENSFMVVNALGDRCVRCEPTFVNTSRSCACS
EPNILTGGLCFSSTGNFPLRRISAARYGEVGMSLTSEWFAKYLQSSAAACWVYANLTSCQALGNMCVMNMNSYDFATFDACGLFQFIFEN
TAGLSTVHSISFWRQNLPWLFYGDQLGLAPQVLSSTSLPTNFSFKGENQNTKLKFVAASYDIRGNFLKWQTLEGGVLQLCPDTETRLNAA
YSFGTTYQQNCEIPISKILIDFPTPIFYDVYLEYTDENQHQYILAVPVLNLNLQHNKIFVNQDSNSGKWLLTRRIFLVDAVSGRENDLGT
QPRVIRVATQISLSVHLVPNTINGNIYPPLITIAYSDIDIKDANSQSVKVSFSVTYEMDHGEAHVQTDIALGVLGGLAVLASLLKTAGWK
RRIGSPMIDLQTVVKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPIQEERFVTYVGCAFALKALQFLHKLISQITIDVF
FIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINSLFQVLTVLFFLEVVGFKNLALMDSSSSLSRNPPSYIAPY
SCILRYAVSAALWLAIGIIQVVFFAVFYERFIEDKIRQFVDLCSMSNISVFLLSHKCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLC
SQRGLVPNTDGQTFEIAISNQMRQHYDRIHETLIRKNGPARLLSSSASTFEQSIKAYHMMNKFLGSFIDHVHKEMDYFIKDKLLLERILG

--------------------------------------------------------------
>3145_3145_2_AHSA1-TMEM67_AHSA1_chr14_77931029_ENST00000535854_TMEM67_chr8_94770711_ENST00000453321_length(transcript)=5000nt_BP=719nt
AAGTTAAGGAGGGGAGGGGGTGGAGGGAAAAGCAAGCCAGGAGGTGCTTGCGGCCGCTTCTAGTAGTTTCCAGGCGCTGCCGGGCGGCTG
GCACTAAGCGGTCCTGAGGCTGTGGCTACGGCTGCTCCGGAGCTGGTGGCGCCGCGATAGGAGAGCCGATGGCCAAGTGGGGTGAGGGAG
ACCCACGCTGGATCGTGGAGGAGCGGGCGGACGCCACCAACGTCAACAACTGGCACTGGACGGAGAGAGATGCTTCAAATTGGTCCACGG
ATAAGCTGAAAACACTGTTCCTGGCAGTGCAGGTTCAAAATGAAGAAGGCAAGTGTGAGGTGACGGAAGTGAGTAAGCTTGATGGAGAGG
CATCCATTAACAATCGCAAAGGGAAACTTATCTTCTTTTATGAATGGAGCGTCAAACTAAACTGGACAGGTACTTCTAAGTCAGGAGTAC
AATACAAAGGACATGTGGAGATCCCCAATTTGTCTGATGAAAACAGCGTGGATGAAGTGGAGATTAGTGTGAGCCTTGCCAAAGATGAGC
CTGACACAAATCTCGTGGCCTTAATGAAGGAAGAAGGGGTGAAACTTCTAAGAGAAGCAATGGGAATTTACATCAGCACCCTCAAAACAG
AGTTCACCCAGGGCATGATCTTACCTACAATGAATGGAGAGTCAGTAGACCCAGTGGGGCAGCCAGCACTGAAAACTGAGGAGCGCAAGA
AAGGTGTTACAGAAGATGGCTGGAACTGCATTTCTTGCCCTAGTGACTTAACTGCCGAAGGAAAATGTCACTGTCCCATTGGCCATATTT
TAGTGGAAAGAGACATTAATGGAACATTGTTGTCTCAAGCAACTTGTGAGCTCTGTGATGGAAATGAAAACTCTTTTATGGTAGTAAATG
CTTTAGGAGACAGGTGCGTCCGATGTGAGCCAACATTTGTTAATACCAGCAGGTCCTGTGCATGTTCAGAACCTAACATTTTAACAGGGG
GATTATGTTTCAGCAGCACAGGGAATTTTCCTCTACGTAGAATTTCAGCTGCACGTTATGGAGAAGTTGGCATGTCTTTAACTTCAGAAT
GGTTTGCAAAGTATTTGCAATCATCAGCAGCTGCATGTTGGGTATATGCCAATCTAACATCTTGTCAAGCTCTTGGAAATATGTGTGTGA
TGAACATGAATTCTTACGACTTTGCCACATTTGATGCATGTGGACTATTTCAGTTTATCTTTGAAAATACTGCTGGACTGAGCACTGTTC
ATTCTATTTCATTTTGGAGACAGAATCTTCCTTGGCTGTTTTATGGAGACCAGTTAGGATTAGCACCTCAAGTGCTCAGTTCTACCTCTC
TTCCTACAAATTTCAGTTTTAAAGGAGAAAACCAGAATACAAAACTGAAGTTTGTTGCTGCTTCCTATGATATAAGAGGAAATTTTCTCA
AGTGGCAAACTTTAGAAGGAGGTGTTTTACAGCTTTGTCCAGACACAGAGACAAGGCTAAATGCTGCTTATTCATTTGGAACAACCTACC
AACAAAATTGTGAGATTCCTATCTCTAAGATCTTAATTGACTTTCCCACTCCTATATTTTATGATGTGTACCTTGAATATACTGATGAAA
ATCAACATCAATATATTTTGGCTGTGCCTGTGTTAAACCTAAATCTTCAACATAATAAGATATTTGTGAACCAAGACAGCAACTCTGGAA
AGTGGCTTCTAACTCGGCGCATTTTCTTAGTGGATGCAGTAAGTGGACGAGAAAATGACTTAGGAACTCAGCCAAGAGTAATTCGAGTTG
CTACTCAAATATCACTGAGTGTCCACCTTGTACCCAACACAATAAATGGAAACATCTACCCTCCCTTAATCACCATTGCCTACAGTGACA
TTGATATCAAAGATGCCAACAGCCAGTCTGTGAAGGTTTCTTTCTCAGTCACATATGAAATGGATCATGGAGAAGCACATGTCCAGACAG
ATATTGCTTTGGGTGTATTGGGTGGGCTAGCTGTTTTAGCATCTCTTTTGAAGACAGCAGGATGGAAGAGGCGCATTGGGAGTCCCATGA
TTGATTTACAGACAGTTGTGAAATTCTTGGTGTACTATGCTGGTGATCTGGCCAATGTTTTCTTTATCATCACAGTGGGAACAGGTCTTT
ACTGGCTTATTTTCTTCAAAGCACAGAAGTCTGTGTCTGTTTTGCTGCCAATGCCAATTCAGGAAGAACGTTTTGTCACTTATGTTGGAT
GTGCCTTTGCTCTGAAGGCACTACAATTTTTGCATAAGCTCATATCCCAGATTACAATAGATGTATTCTTTATTGATTGGGAGCGACCTA
AAGGAAAGGTTCTTAAAGCTGTTGAAGGTGAGGGTGGTGTACGAAGTGCCACTGTTCCTGTAAGCATATGGAGAACATATTTTGTAGCAA
ATGAATGGAATGAAATTCAGACTGTGAGAAAAATTAATTCACTCTTTCAAGTACTTACTGTCCTCTTCTTTTTGGAGGTTGTGGGATTCA
AGAACTTAGCATTAATGGACTCATCTTCTAGTCTTTCTAGAAACCCACCTAGCTACATAGCTCCTTATAGCTGCATTTTGAGATATGCAG
TGTCTGCTGCTCTTTGGCTAGCCATTGGAATTATACAGGTCGTGTTCTTTGCTGTCTTTTATGAGAGATTTATAGAAGATAAAATTCGAC
AGTTCGTTGATTTATGCTCTATGAGTAATATATCAGTGTTTCTGTTATCCCACAAATGTTTTGGATATTACATTCATGGTAGATCAGTAC
ATGGGCATGCAGATACTAATATGGAAGAAATGAATATGAACCTTAAAAGAGAAGCGGAAAATTTGTGTAGCCAGAGAGGTTTGGTACCCA
ACACAGATGGTCAGACTTTTGAGATTGCAATTTCTAACCAGATGAGACAACATTATGACAGAATTCATGAGACACTAATAAGGAAAAATG
GTCCTGCTAGACTACTGAGTTCATCAGCAAGTACTTTTGAGCAGAGTATAAAAGCATATCATATGATGAATAAATTTCTTGGCTCCTTCA
TTGACCATGTTCATAAGGAAATGGATTACTTTATAAAAGATAAGTTGCTTCTTGAAAGAATTCTTGGAATGGAATTCATGGAACCAATGG
AAAAAAGCATCTTTTACAATGATGAAGGTTATTCTTTCAGCAGTGTCCTGTATTATGGAAATGAAGCTACTCTTCTTATTTTTGATCTGC
TGTTCTTCTGTGTTGTGGATTTGGCTTGCCAAAATTTTATTTTAGCATCCTTCCTTACATATCTACAACAAGAGATTTTTAGATATATCC
GTAATACAGTAGGACAAAAGAATTTGGCATCCAAAACATTGGTGGATCAAAGATTTTTGATTTAACTTCCTGAATAAATAACTTAAAGAC
TCAGTATAATCATGGCCAAAAAAAAGTCATGATATCAGGTTAGTTTGCCATATTTTTTAAAACTTATAATGCAGACTATTCTGTTTTTGT
TTTTTATTTGCAGAAAGATTTATTTTTATAACTTGGGAATATATAACCTGATATAATAGAAAATACTGTTTTCCCATTGTGTGTAGTATT
TAATGCAGTAAATAATAAATTAATACTGACAGTGAGGCCAAAAAAAATCTAAATGTTGCTTTCAGCATAATACTTTTTAATGCTAATTAA
AACAGTCCCCATCATTTGTCTCTGTAGATTATTTTATAAACTGAGAGCTGCCTGAATCTTCTCACATTGACAAAGTAATTTGATTCCAAG
TTTAAGACTAGTTTTCAGTTTGATATTTTCATGTTTTGTGTGCTTATGGTTAAATAAATGTTGAAAGATATTTTCAAGTTTACTTAGAAA
TTTTAAATTGTATTATTGCTGATTCAATTTGCATCATTCTAATTGCTCATCCTCTTTGGCAGTGGATTAATTCACTGTTGGGTTAATATG
CATCTCATGAAATGATATCTTTTCATTCCTTTGTATACCTGTATTAGGTCAGTATACGCTTTCCATGAAATATATTTGCATTTCTAATAT
AGTTTACATTTATTAAGTTATAACGTATGACATTTTTCCCAATATCATTTTTTATACATTTTAATTACTTAATGTTTTAAGAGTTCTCTT
CCAGAGTTTTGCTTTTCAATTACGTTTAAAGACTGTAAATAACAAACAGTAAGGCTGGGCGCTGTGGCTTACGCCTGTAATCCCAGCACT
TTGGAAGGCCAAGGCACGTGGATCACTTTAGGTCAGGAGTTCAAGAACAGCCTGGCCAACATGGAAAACCCCATCTCTACAAAAAATACA
AAAATTAGTTGGATGTGGTGGCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCATGAGAATAGCTTGAAACCAGGAGGTGGAGGCTGTAG
TGAGCCAGATAGCACCACTGCACTCCAGCCAGGATGACAGAGCAAGACCCTGTCTCAGAAAAAACAAAAACAAAACACTGTAAATGTATC
ATGTTTCTCACTGCTTTCTATGTTAATGCTGTGTAAATACTTAAAATGGAATACTGTATAAATATTATTTATATTTTCTCAGATGAAAAT
ATATACTAAAACATTTGGTATTTCTGTTTTCTGTTTCATTAATGTATATCTGATGGAGTACCATTTAGGAATATAACATTATTGGGGCAG
AGGTCCCAGCCATTGCCAAAGTTGAATCTTTTACATTTCCCTGAATCTTGAGGATGACTGAAAAGGAAGTCTTTGAAACTGCAGTTTCTG
AAGGATCACAGTACAGGAATGCCTTTATAAAAGCTGCAGAGATAAATACATGTACTTATATGGCATGGATATTTAAAACCACTCACTCAG
AAGCATATGAAAGAAATTCAACCATCATTCAACATAGAAGAAGTTAATTTTAGTGCAAAAGTTTTTAAGTATTAAATTTCACAATAAAGG

>3145_3145_2_AHSA1-TMEM67_AHSA1_chr14_77931029_ENST00000535854_TMEM67_chr8_94770711_ENST00000453321_length(amino acids)=1078AA_BP=187
MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWT
GTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPA
LKTEERKKGVTEDGWNCISCPSDLTAEGKCHCPIGHILVERDINGTLLSQATCELCDGNENSFMVVNALGDRCVRCEPTFVNTSRSCACS
EPNILTGGLCFSSTGNFPLRRISAARYGEVGMSLTSEWFAKYLQSSAAACWVYANLTSCQALGNMCVMNMNSYDFATFDACGLFQFIFEN
TAGLSTVHSISFWRQNLPWLFYGDQLGLAPQVLSSTSLPTNFSFKGENQNTKLKFVAASYDIRGNFLKWQTLEGGVLQLCPDTETRLNAA
YSFGTTYQQNCEIPISKILIDFPTPIFYDVYLEYTDENQHQYILAVPVLNLNLQHNKIFVNQDSNSGKWLLTRRIFLVDAVSGRENDLGT
QPRVIRVATQISLSVHLVPNTINGNIYPPLITIAYSDIDIKDANSQSVKVSFSVTYEMDHGEAHVQTDIALGVLGGLAVLASLLKTAGWK
RRIGSPMIDLQTVVKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPIQEERFVTYVGCAFALKALQFLHKLISQITIDVF
FIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINSLFQVLTVLFFLEVVGFKNLALMDSSSSLSRNPPSYIAPY
SCILRYAVSAALWLAIGIIQVVFFAVFYERFIEDKIRQFVDLCSMSNISVFLLSHKCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLC
SQRGLVPNTDGQTFEIAISNQMRQHYDRIHETLIRKNGPARLLSSSASTFEQSIKAYHMMNKFLGSFIDHVHKEMDYFIKDKLLLERILG

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Top

Fusion Gene PPI Analysis for AHSA1-TMEM67

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AHSA1-TMEM67

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AHSA1-TMEM67

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source