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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FRYL-DTD1 (FusionGDB2 ID:31486)

Fusion Gene Summary for FRYL-DTD1

check button Fusion gene summary
Fusion gene informationFusion gene name: FRYL-DTD1
Fusion gene ID: 31486
HgeneTgene
Gene symbol

FRYL

DTD1

Gene ID

285527

92675

Gene nameFRY like transcription coactivatorD-aminoacyl-tRNA deacylase 1
SynonymsAF4p12|KIAA0826|MOR2C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68
Cytomap

4p11

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homologD-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2
Modification date2020031320200313
UniProtAcc

O94915

Q8TEA8

Ensembl transtripts involved in fusion geneENST00000358350, ENST00000503238, 
ENST00000507711, ENST00000537810, 
ENST00000264319, ENST00000506685, 
ENST00000507873, ENST00000514783, 
ENST00000494921, ENST00000377452, 
Fusion gene scores* DoF score21 X 23 X 13=627913 X 8 X 8=832
# samples 3618
** MAII scorelog2(36/6279*10)=-4.12446600064719
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/832*10)=-2.20858662181142
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRYL [Title/Abstract] AND DTD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRYL(48621291)-DTD1(18724744), # samples:3
Anticipated loss of major functional domain due to fusion event.FRYL-DTD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FRYL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DTD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5D7-01AFRYLchr4

48621291

-DTD1chr20

18724744

+
ChimerDB4BRCATCGA-OL-A5D7FRYLchr4

48621290

-DTD1chr20

18724743

+


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Fusion Gene ORF analysis for FRYL-DTD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358350ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000358350ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+
5CDS-intronENST00000503238ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000503238ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+
5CDS-intronENST00000507711ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000507711ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+
5CDS-intronENST00000537810ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
5CDS-intronENST00000537810ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+
5UTR-3CDSENST00000264319ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
5UTR-3CDSENST00000264319ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
5UTR-intronENST00000264319ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
5UTR-intronENST00000264319ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+
Frame-shiftENST00000358350ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
Frame-shiftENST00000358350ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
Frame-shiftENST00000503238ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
Frame-shiftENST00000503238ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
Frame-shiftENST00000507711ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
Frame-shiftENST00000507711ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
Frame-shiftENST00000537810ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
Frame-shiftENST00000537810ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
intron-3CDSENST00000506685ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-3CDSENST00000506685ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
intron-3CDSENST00000507873ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-3CDSENST00000507873ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
intron-3CDSENST00000514783ENST00000377452FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-3CDSENST00000514783ENST00000377452FRYLchr4

48621290

-DTD1chr20

18724743

+
intron-intronENST00000506685ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-intronENST00000506685ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+
intron-intronENST00000507873ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-intronENST00000507873ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+
intron-intronENST00000514783ENST00000494921FRYLchr4

48621291

-DTD1chr20

18724744

+
intron-intronENST00000514783ENST00000494921FRYLchr4

48621290

-DTD1chr20

18724743

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FRYL-DTD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FRYLchr448621290-DTD1chr2018724743+4.52E-050.9999548
FRYLchr448621290-DTD1chr2018724743+4.52E-050.9999548
FRYLchr448621290-DTD1chr2018724743+4.52E-050.9999548
FRYLchr448621290-DTD1chr2018724743+4.52E-050.9999548

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FRYL-DTD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48621291/:18724744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRYL

O94915

DTD1

Q8TEA8

FUNCTION: Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.FUNCTION: Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FRYL-DTD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FRYL-DTD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FRYL-DTD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FRYL-DTD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource