FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FTCDNL1-ALS2CR11 (FusionGDB2 ID:31583)

Fusion Gene Summary for FTCDNL1-ALS2CR11

check button Fusion gene summary
Fusion gene informationFusion gene name: FTCDNL1-ALS2CR11
Fusion gene ID: 31583
HgeneTgene
Gene symbol

FTCDNL1

ALS2CR11

Gene ID

348751

151254

Gene nameformiminotransferase cyclodeaminase N-terminal likeC2 calcium dependent domain containing 6
SynonymsFONGALS2CR11
Cytomap

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionformiminotransferase N-terminal subdomain-containing proteinformiminotransferase N-terminal sub-domain containingformiminotransferase-cyclodeaminase N-terminal-like proteinC2 calcium-dependent domain-containing protein 6amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 proteinamyotrophic lateral sclerosis 2 chromosome region cand
Modification date2020031320200313
UniProtAcc

E5RQL4

.
Ensembl transtripts involved in fusion geneENST00000416668, ENST00000420128, 
ENST00000420922, 		ENST00000450242, 
ENST00000482942, ENST00000286195, 
ENST00000439140, ENST00000439802, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 4 X 3=36
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FTCDNL1 [Title/Abstract] AND ALS2CR11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFTCDNL1(200710798)-ALS2CR11(202469420), # samples:1
FTCDNL1(200684295)-ALS2CR11(202469420), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FTCDNL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALS2CR11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01AFTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
ChimerDB4STADTCGA-BR-A4QI-01AFTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-


Top

Fusion Gene ORF analysis for FTCDNL1-ALS2CR11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000416668ENST00000450242FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
5CDS-intronENST00000416668ENST00000482942FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
5CDS-intronENST00000420128ENST00000450242FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
5CDS-intronENST00000420128ENST00000450242FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
5CDS-intronENST00000420128ENST00000482942FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
5CDS-intronENST00000420128ENST00000482942FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
5CDS-intronENST00000420922ENST00000450242FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
5CDS-intronENST00000420922ENST00000482942FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000416668ENST00000286195FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000416668ENST00000439140FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000416668ENST00000439802FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000420128ENST00000286195FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000420128ENST00000286195FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000420128ENST00000439140FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000420128ENST00000439140FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000420128ENST00000439802FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
Frame-shiftENST00000420128ENST00000439802FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
In-frameENST00000420922ENST00000286195FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
In-frameENST00000420922ENST00000439140FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
In-frameENST00000420922ENST00000439802FTCDNL1chr2

200710798

-ALS2CR11chr2

202469420

-
intron-3CDSENST00000416668ENST00000286195FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-3CDSENST00000416668ENST00000439140FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-3CDSENST00000416668ENST00000439802FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-3CDSENST00000420922ENST00000286195FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-3CDSENST00000420922ENST00000439140FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-3CDSENST00000420922ENST00000439802FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-intronENST00000416668ENST00000450242FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-intronENST00000416668ENST00000482942FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-intronENST00000420922ENST00000450242FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-
intron-intronENST00000420922ENST00000482942FTCDNL1chr2

200684295

-ALS2CR11chr2

202469420

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420922FTCDNL1chr2200710798-ENST00000286195ALS2CR11chr2202469420-21613333181973551
ENST00000420922FTCDNL1chr2200710798-ENST00000439802ALS2CR11chr2202469420-17173333181289323
ENST00000420922FTCDNL1chr2200710798-ENST00000439140ALS2CR11chr2202469420-556933331855641748

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420922ENST00000286195FTCDNL1chr2200710798-ALS2CR11chr2202469420-0.0014014040.99859864
ENST00000420922ENST00000439802FTCDNL1chr2200710798-ALS2CR11chr2202469420-0.0005883150.9994117
ENST00000420922ENST00000439140FTCDNL1chr2200710798-ALS2CR11chr2202469420-0.0003196420.9996804

Top

Fusion Genomic Features for FTCDNL1-ALS2CR11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FTCDNL1-ALS2CR11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:200710798/chr2:202469420)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FTCDNL1

E5RQL4

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALS2CR11chr2:200710798chr2:202469420ENST0000028619501587_22277624.0DomainC2
TgeneALS2CR11chr2:200710798chr2:202469420ENST0000043914001687_222771821.0DomainC2
TgeneALS2CR11chr2:200710798chr2:202469420ENST0000043980201387_22277433.0DomainC2
TgeneALS2CR11chr2:200710798chr2:202469420ENST0000045024201387_22277551.0DomainC2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for FTCDNL1-ALS2CR11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31583_31583_1_FTCDNL1-ALS2CR11_FTCDNL1_chr2_200710798_ENST00000420922_ALS2CR11_chr2_202469420_ENST00000286195_length(transcript)=2161nt_BP=333nt
CTCCACCCAGGAACCTAGTCGGCACCGCGCAGGGAATCCCAGCAGCGGGGTTCTGGCCCCAGCACGCGTTGCGGCAGCCTGGCGAGCGTC
CTTGCGGCCTCCAAGTGCCGGTGGGAAAAATCATGTCTTCTTCCAGAGTGGGGCTCCGTTTGGCTGCCTGTTTACTAAACGTTTCAGAAG
CCGGAAGAAAATACATTGTTGAGAACATAGCAAAAGCAGCTCTTCTTGACAAAAATGGAAAGAAACATCCTCAAGTTTCAGTGCTCAATA
TATTTTCCGATCAAGACTACAAGAGATCAGTCATTACAATAGCAACTTCTGTTGATAAGTTGGATGCTGAGAAAAACTCTTAAAGAGTCT
GATAGTGAAGAACTGGAAATAACACAGGAGACGCCAAATTTGGTGCCATTTGGGGATGTGGTTGGCTGCCTGGGCATTCATATAAAGAAC
TGCAGACATTTTATGCCTAAGATCAGTTTACAACATTATGCTAATTTATTCATTCGCATCTCTATAAACAAAGCTGTGAAATGTACAAAA
ATGTGTAGCTTGCTATCCAAAAACGATGAGAAGAACACTGTAATTAAGTTCGATGAAGTGAAGTATTTTTCTGTACAGGTTCCCAGACGT
TATGATGATAAGCGGAATAATATTTTATTGGAACTCATACAATATGACAATAGAGAAAAACGTGCTTTCTTGTTAGGGAGTGTTCAGATA
CATCTTTATGAGGTAATTCAGAAAGGGTGCTTCATTGAAGAGGTCCAAGTGTTGCATGGAAACATATTTGTCTGCAGGCTGGAGGTGGAA
TTTATGTTCTCCTATGGAAACTTTGGTTATGGATTTTCACATCAGTTAAAACCTCTTCAGAAAATTACTGAGCCATCCATGTTTATGAAT
CTTGCACCACCTCCAGAAAGAACAGATCCCGTGACAAAAGTTATTACACCACAGACAGTAGAATATCCAGCATTCTTATCCCCAGACCTG
AATGTTACTGTTGGGACTCCAGCTGTGCAATCCTCCAACCAGCCATCTGTAGTGCGACTTGAAAAACTTCAGCAACAACCCCGGGAAAGG
CTGGAAAAGATGAAAAAAGAATATAGAAATCTGAATACATGGATAGATAAAGCTAACTATTTAGAAAGCATTCTAATGCCAAAATTGGAA
CATAAGGATTCTGAGGAAACTAATATAGATGAGGCATCTGAAAACACGAAAAGTAATCATCCTGAAGAGGAGCTTGAAAATATTGTAGGA
GTAGATATCCCTCTTGTAAATGAGGAAGCTGAAACTACTGCAAATGAGTTACTGGATAATGATTCTGAGAAAGGCCTGACTATACCAACT
TTGAACCAATCGGACCAAGATAATTCAACTGCTGATGCTTCTAAAAATGATGAATCAACACCTTCACCCACAGAAGTGCACTCATTGTGC
ACTATTTCTAACCAGGAAACAATAAAAGCAGGCAGAATACCACCTTTAGGTGAACGTCAATCAGAAAGCATGCCAGACAGAAAAATGAAA
AATGTATTTTTTCCATTAGAAGTAAAATTAAAAGATAACTATCCAAGCATTTTAAAAGCAGACTCATCTCTATCAGAGGTGGCTTTTTCA
CCAAAAGAATATAATTCACCATCTTTCAGACCAGAATATATAGAATTCAAACCAAAATTTCAGGATTGTTCAGATAAATTTGAGGATTTA
CATGACATGACCTCATTTACACACCTTAAAAAAGTAAAATCAAGATCAAGGCTTTTAGGAAAAAGCTCAGATGATATCCATAACCATGCC
AGACACTCTGCAAGACCATATACTGCTCCGGAGGTTAACAAGCAACGAGAAAGCTACAGTGGAAAGTTTACAAGTCGTCGAATGGTTTCA
TCAGGCTTAGTTCATATAAATGATAAAACATCAGATTATGAAATGCATAAAATGCGGCCAAAAAAAATTAAAAGAGGATATTGAAAAATG
TTCGCTCATTTGTGATATTATAAAACATGTTTAACTCAGAATGATATGTGAGGCCAGCAGTCAGAATATCACTTCTCCATTAACAAAATG
GTTTGGAGATCTCTTCTTTTGTGTGACAGAAGTCAGCAACCAAATTTCATCTTGTTAGAACCATTTTGTTTTGATTAAAATGAAAAACAA

>31583_31583_1_FTCDNL1-ALS2CR11_FTCDNL1_chr2_200710798_ENST00000420922_ALS2CR11_chr2_202469420_ENST00000286195_length(amino acids)=551AA_BP=5
MLISWMLRKTLKESDSEELEITQETPNLVPFGDVVGCLGIHIKNCRHFMPKISLQHYANLFIRISINKAVKCTKMCSLLSKNDEKNTVIK
FDEVKYFSVQVPRRYDDKRNNILLELIQYDNREKRAFLLGSVQIHLYEVIQKGCFIEEVQVLHGNIFVCRLEVEFMFSYGNFGYGFSHQL
KPLQKITEPSMFMNLAPPPERTDPVTKVITPQTVEYPAFLSPDLNVTVGTPAVQSSNQPSVVRLEKLQQQPRERLEKMKKEYRNLNTWID
KANYLESILMPKLEHKDSEETNIDEASENTKSNHPEEELENIVGVDIPLVNEEAETTANELLDNDSEKGLTIPTLNQSDQDNSTADASKN
DESTPSPTEVHSLCTISNQETIKAGRIPPLGERQSESMPDRKMKNVFFPLEVKLKDNYPSILKADSSLSEVAFSPKEYNSPSFRPEYIEF
KPKFQDCSDKFEDLHDMTSFTHLKKVKSRSRLLGKSSDDIHNHARHSARPYTAPEVNKQRESYSGKFTSRRMVSSGLVHINDKTSDYEMH

--------------------------------------------------------------
>31583_31583_2_FTCDNL1-ALS2CR11_FTCDNL1_chr2_200710798_ENST00000420922_ALS2CR11_chr2_202469420_ENST00000439140_length(transcript)=5569nt_BP=333nt
CTCCACCCAGGAACCTAGTCGGCACCGCGCAGGGAATCCCAGCAGCGGGGTTCTGGCCCCAGCACGCGTTGCGGCAGCCTGGCGAGCGTC
CTTGCGGCCTCCAAGTGCCGGTGGGAAAAATCATGTCTTCTTCCAGAGTGGGGCTCCGTTTGGCTGCCTGTTTACTAAACGTTTCAGAAG
CCGGAAGAAAATACATTGTTGAGAACATAGCAAAAGCAGCTCTTCTTGACAAAAATGGAAAGAAACATCCTCAAGTTTCAGTGCTCAATA
TATTTTCCGATCAAGACTACAAGAGATCAGTCATTACAATAGCAACTTCTGTTGATAAGTTGGATGCTGAGAAAAACTCTTAAAGAGTCT
GATAGTGAAGAACTGGAAATAACACAGGAGACGCCAAATTTGGTGCCATTTGGGGATGTGGTTGGCTGCCTGGGCATTCATATAAAGAAC
TGCAGACATTTTATGCCTAAGATCAGTTTACAACATTATGCTAATTTATTCATTCGCATCTCTATAAACAAAGCTGTGAAATGTACAAAA
ATGTGTAGCTTGCTATCCAAAAACGATGAGAAGAACACTGTAATTAAGTTCGATGAAGTGAAGTATTTTTCTGTACAGGTTCCCAGACGT
TATGATGATAAGCGGAATAATATTTTATTGGAACTCATACAATATGACAATAGAGAAAAACGTGCTTTCTTGTTAGGGAGTGTTCAGATA
CATCTTTATGAGGTAATTCAGAAAGGGTGCTTCATTGAAGAGGTCCAAGTGTTGCATGGAAACATATTTGTCTGCAGGCTGGAGGTGGAA
TTTATGTTCTCCTATGGAAACTTTGGTTATGGATTTTCACATCAGTTAAAACCTCTTCAGAAAATTACTGAGCCATCCATGTTTATGAAT
CTTGCACCACCTCCAGAAAGAACAGATCCCGTGACAAAAGTTATTACACCACAGACAGTAGAATATCCAGCATTCTTATCCCCAGACCTG
AATGTTACTGTTGGGACTCCAGCTGTGCAATCCTCCAACCAGCCATCTGTAGTGCGACTTGAAAAACTTCAGCAACAACCCCGGGAAAGG
CTGGAAAAGATGAAAAAAGAATATAGAAATCTGAATACATGGATAGATAAAGCTAACTATTTAGAAAGCATTCTAATGCCAAAATTGGAA
CATAAGGATTCTGAGGAAACTAATATAGATGAGGCATCTGAAAACACGAAAAGTAATCATCCTGAAGAGGAGCTTGAAAATATTGTAGGA
GTAGATATCCCTCTTGTAAATGAGGAAGCTGAAACTACTGCAAATGAGTTACTGGATAATGATTCTGAGAAAGGCCTGACTATACCAACT
TTGAACCAATCGGACCAAGATAATTCAACTGCTGATGCTTCTAAAAATGATGAATCAACACCTTCACCCACAGAAGTGCACTCATTGTGC
ACTATTTCTAACCAGGAAACAATAAAAGCAGGCAGAATACCACCTTTAGGTGAACGTCAATCAGAAAGCATGCCAGACAGAAAAATGAAA
AATGTATTTTTTCCATTAGAAGTAAAATTAAAAGATAACTATCCAAGCATTTTAAAAGCAGACTCATCTCTATCAGAGGTGGCTTTTTCA
CCAAAAGAATATAATTCACCATCTTTCAGACCAGAATATATAGAATTCAAACCAAAATTTCAGTTTCAGAAATTCAACAAGAACGGTTTT
GATCCTTTTCTAAGGAATATAAACAAAATGTCAGTCAGAAAAAGAAAAGATCAAGATATATACAAATATAGAAATATCTTAGGTGCAGAG
GTCATAGAGCATGAAGACCAGGATCCTCCTTATCCAGCACAATCAAAAACTGCAGGACCTGCTAATACAACCTGGGCCCATGACCCTAAT
ATCTTCACAACAAAGATGTTAGAAACTGAGAATAAGTTAGCCCCTGATCCTACTATCAATACAATAAAGGGTTTAGATACAAAGAATAGT
TTAAAAGAAAATCTACCAAATGTATCTTTACCAAGCATCAAAGGAGAATCATCAAGGGCTGGAAATGTACAGGCAAACACATGTCACCTC
TCGAAGTCTTTAAATTTTACCCCCCATATAGAATATTTAAAACAATCAATGATACTCAAGTCAATTTTAAGTGAAAATCTGCAAGACCTT
TCAGACAAATTATTTTCTAAACCAGAAGTTAGTATGAACAGTGAAGCAAGAGAGAAAAGTAGTTCTCCACTTCTAAGCATTCATGATAAA
TCATCAAGTAGTATGGAAGACAACGTATTGGAAAAAAAACAAGATTTAAACAACTGGCTTTCAGAAAAAGACATTTTAAATTCAAAGACT
ACTTTAAGTCAAATAATTAAAAATATTCCTGCAGATTCATTTTCAGAAGGTAGTCAAATAATTGAAAATATTCCTGCAGATTCACTTTTA
GAAGGTGGTCAAGTAATTAAAAATATTCCTGAATATTCACTTTCAGAAGGGGGTCAGATAATTAAAAATATTCCTGCAGATTCATTTTTA
GAAAGTGGACCAGGACAATCTCCAGAGGTAGAAGAACATGTCTCTAAAAAACACTTCGAAGCTGATGAGAGAGATTTTCCAATTAAAAAA
AATAGTAGTACCAAAAAGAAACATTTAATAAGCGAAGTACCTAACTCCAAATCAGGTTCAAGTGGCACTGTACATGACTACATTATGAGG
CAAATATTCACTGCACCAATATTCTCAGAATTGGAGATAGAAGTGAAAGAGCCAAGTGAAACACCAATGAACTTGGAAAATCAATTACCT
ACACCTTGGAAGAGAAGTTTGTCATCACATATTCTATTTCATGAAGAAAATGCTGATGAAATAGAATTGCCACAGCCCAGATCTGCTACA
AGCCAGATAATACAAGCATTTCCTATAGATACACTTTTAGAATCTGGGATAATCAAAGTGATAGAATTAGATAAAGAACACCATAAGAGT
TCTTTGCTGGGTACGGGGATCACTTCTCCTAAAGGAAACCTAAAGGATTCCCAAGAGTATTATTCAGAAATCAGAAGCGAGACAGAACCT
CTTTCTGAGCAGAGTATACCCATCATTCCCAAAGACACTACTTCTGTTAGTAGAGCTGAATTTATACAGGAAGACCAAAATATGTTCCCA
CAAGATTCAAGTTATTATTCAATAGCAAATAAAGAACTGTATTTGCCAAGAAATGGTCAGAGGCTTTGTAAAGACAAAAATGATCTCAGT
TCTACTTTAGAAAGTTTAACTAACTCATTAATGGATAAACTTAGTGAATCAGATGAAATAATGTTAAAATCCTTTTTAAAAAACATCTTC
AATGTTTTTTTCAAATATAATCATTCTGAAAGAAGAGGACAACCAGAAAAAGAATTAGAAAGACTAATTCAACCTTCTTTTACAAGTGAC
ACAGAACACCTTGAAGAACTCCAAGAGGATTTTGATAAAGCAGACAAATTAGACAGAAAACCTATTTTGAGTCCAAAGTTGCGTGTGTTT
CTAGAAGAACTCTCAGAGTCAGAAGTAAAACATTTAAAATCTGAATTAAGTAAACAAATCCAGCATTACCTTGTAGAAAGACTTTCAGAA
TCAGGACATATCACCAAGGAGGACTTACCAAAAATCTATCAAAATCTGTATCTGATGAATGAGAAAGCAGAGCAGAAAGGGCCAAACAGT
TTTCAGGGGAAATATTCTGAAACTGTGAAAGAAATCATGTCTTTTGTCAACAATTTCAATCATCATTTCATAGATAAACATTTGGAAATA
AAGCTGAGATCTTTTTTAAAAGAGATTCTCCAAAACTATTTCCTAAAAAACATTTCAGAAAGCAGTTTATTTAATGAGACAGCATCTGAG
ACTATATACCCAAACATATCTTCTCTAAGGACTAAAAGTGTCTCAATATCTTTTCATGAACTAGAACAAGATATTTCAAAGGGGAGTTTT
GGTAGAAGGTTTGAAATAAACATGAAATATCCTTTAAGTAAATCTCTACAAAACTATCTGATAGCTTTATCAGAAAATGAATTATTACAT
CTAAAAGCTGATTTAAGCAAACACCTCCAGAGTCTTTTTATAGAAAAACTTTCAAAATCAGGACTAATGACAAAAAAGCAATTAGAAGGG
ATCAACCAGCATATAAATTTGCTTAATTCTAGTTCTATACCATTAAAATATATAAAAACACATTTACCTTTTAGAGATGACTGTCACTTT
GTGGAGAAGCATTCAGAAAAGCAAAATAAATATTCAAGAATTGTTCAACAAACCACTTTACAAACGGTTTCTGAGGATAAACTTAGAGAA
GCAGAATTGATTCGAGAGAAAGAAAAGAAATATTTTCCCTTACAGAATTTAAAGGGAAATTCATCTTTAATTAAGGAACAGAAAAGTTAT
TACACTAAGGAAGAAGCTAAAACACCAAGTTTAATCAAAGTACAACCTTCTTCCAATGAAAATATCCAGGCAAGTCCATTAAGTAAGTCA
TCAGAAATACTTACAGATATACTGCTTAAGAAACTAAGGAAAGAACATGTATTCACGCAGCTTCCTCAAGCAGAAAATTCTGTTCATAAA
ACAGAGATTCAAGACCCATATAGTTGGGGTGGTAAATCAAAAATAACTCAATCAAAAGCTTGGTGTGAAAAGACACTGAAAATGAAGTCC
CTTGATAGAAAGGAGCATGTAAACATCTATAAATGGACTGTTCAGGAAAAACCTGAAGCAGTATTAACATCGTATCCAAGAATTCCTAAT
GCCAGAATGCCAAGGGAAGATGAGTACTTAAACAGAATCACTTTCCCTTCCTGGCAAAGTAGCACTTTAACTCATTTCAATACAGAGACT
GGGGAAAAATCAAAATTAGAAGACCAGTATTGTCAGACATTGAAAGGAAATAATAACAATAATAAAAAGCATTTAGTAACATTTGCACAA
TACAAAAAAGAAATACAAACTCTTTATATAAAACCAGATGAAATTTGCAGTGAAAAATGTGCCAAGTTCCCTGAAATACAGTCATTCCAA
TATAAGGTTGTAGAAGATGAGAAAAACTTGAAACCACACCTCTTCCCAGAATTATTTAAGATAGAAGATCTAAAACCCAAGGTCCGAAAA
GAAAGAGACCGTGTCGCCCAACCAAAAAAGTCATTTAACAAGATAGTCAGGATACTACCAACCACACTGCCCACCACAAGAATTCACCTA
AAGAAGTCTGTTCCAAGGACACTGCTTCACTGGACTGCAAGAAGAACTATACATGATTGTTCAGATAAATTTGAGGATTTACATGACATG
ACCTCATTTACACACCTTAAAAAAGTAAAATCAAGATCAAGGCTTTTAGGAAAAAGCTCAGATGATATCCATAACCATGCCAGACACTCT
GCAAGACCATATACTGCTCCGGAGGTTAACAAGCAACGAGAAAGCTACAGTGGAAAGTTTACAAGTCGTCGAATGGTTTCATCAGGCTTA

>31583_31583_2_FTCDNL1-ALS2CR11_FTCDNL1_chr2_200710798_ENST00000420922_ALS2CR11_chr2_202469420_ENST00000439140_length(amino acids)=1748AA_BP=5
MLISWMLRKTLKESDSEELEITQETPNLVPFGDVVGCLGIHIKNCRHFMPKISLQHYANLFIRISINKAVKCTKMCSLLSKNDEKNTVIK
FDEVKYFSVQVPRRYDDKRNNILLELIQYDNREKRAFLLGSVQIHLYEVIQKGCFIEEVQVLHGNIFVCRLEVEFMFSYGNFGYGFSHQL
KPLQKITEPSMFMNLAPPPERTDPVTKVITPQTVEYPAFLSPDLNVTVGTPAVQSSNQPSVVRLEKLQQQPRERLEKMKKEYRNLNTWID
KANYLESILMPKLEHKDSEETNIDEASENTKSNHPEEELENIVGVDIPLVNEEAETTANELLDNDSEKGLTIPTLNQSDQDNSTADASKN
DESTPSPTEVHSLCTISNQETIKAGRIPPLGERQSESMPDRKMKNVFFPLEVKLKDNYPSILKADSSLSEVAFSPKEYNSPSFRPEYIEF
KPKFQFQKFNKNGFDPFLRNINKMSVRKRKDQDIYKYRNILGAEVIEHEDQDPPYPAQSKTAGPANTTWAHDPNIFTTKMLETENKLAPD
PTINTIKGLDTKNSLKENLPNVSLPSIKGESSRAGNVQANTCHLSKSLNFTPHIEYLKQSMILKSILSENLQDLSDKLFSKPEVSMNSEA
REKSSSPLLSIHDKSSSSMEDNVLEKKQDLNNWLSEKDILNSKTTLSQIIKNIPADSFSEGSQIIENIPADSLLEGGQVIKNIPEYSLSE
GGQIIKNIPADSFLESGPGQSPEVEEHVSKKHFEADERDFPIKKNSSTKKKHLISEVPNSKSGSSGTVHDYIMRQIFTAPIFSELEIEVK
EPSETPMNLENQLPTPWKRSLSSHILFHEENADEIELPQPRSATSQIIQAFPIDTLLESGIIKVIELDKEHHKSSLLGTGITSPKGNLKD
SQEYYSEIRSETEPLSEQSIPIIPKDTTSVSRAEFIQEDQNMFPQDSSYYSIANKELYLPRNGQRLCKDKNDLSSTLESLTNSLMDKLSE
SDEIMLKSFLKNIFNVFFKYNHSERRGQPEKELERLIQPSFTSDTEHLEELQEDFDKADKLDRKPILSPKLRVFLEELSESEVKHLKSEL
SKQIQHYLVERLSESGHITKEDLPKIYQNLYLMNEKAEQKGPNSFQGKYSETVKEIMSFVNNFNHHFIDKHLEIKLRSFLKEILQNYFLK
NISESSLFNETASETIYPNISSLRTKSVSISFHELEQDISKGSFGRRFEINMKYPLSKSLQNYLIALSENELLHLKADLSKHLQSLFIEK
LSKSGLMTKKQLEGINQHINLLNSSSIPLKYIKTHLPFRDDCHFVEKHSEKQNKYSRIVQQTTLQTVSEDKLREAELIREKEKKYFPLQN
LKGNSSLIKEQKSYYTKEEAKTPSLIKVQPSSNENIQASPLSKSSEILTDILLKKLRKEHVFTQLPQAENSVHKTEIQDPYSWGGKSKIT
QSKAWCEKTLKMKSLDRKEHVNIYKWTVQEKPEAVLTSYPRIPNARMPREDEYLNRITFPSWQSSTLTHFNTETGEKSKLEDQYCQTLKG
NNNNNKKHLVTFAQYKKEIQTLYIKPDEICSEKCAKFPEIQSFQYKVVEDEKNLKPHLFPELFKIEDLKPKVRKERDRVAQPKKSFNKIV
RILPTTLPTTRIHLKKSVPRTLLHWTARRTIHDCSDKFEDLHDMTSFTHLKKVKSRSRLLGKSSDDIHNHARHSARPYTAPEVNKQRESY

--------------------------------------------------------------
>31583_31583_3_FTCDNL1-ALS2CR11_FTCDNL1_chr2_200710798_ENST00000420922_ALS2CR11_chr2_202469420_ENST00000439802_length(transcript)=1717nt_BP=333nt
CTCCACCCAGGAACCTAGTCGGCACCGCGCAGGGAATCCCAGCAGCGGGGTTCTGGCCCCAGCACGCGTTGCGGCAGCCTGGCGAGCGTC
CTTGCGGCCTCCAAGTGCCGGTGGGAAAAATCATGTCTTCTTCCAGAGTGGGGCTCCGTTTGGCTGCCTGTTTACTAAACGTTTCAGAAG
CCGGAAGAAAATACATTGTTGAGAACATAGCAAAAGCAGCTCTTCTTGACAAAAATGGAAAGAAACATCCTCAAGTTTCAGTGCTCAATA
TATTTTCCGATCAAGACTACAAGAGATCAGTCATTACAATAGCAACTTCTGTTGATAAGTTGGATGCTGAGAAAAACTCTTAAAGAGTCT
GATAGTGAAGAACTGGAAATAACACAGGAGACGCCAAATTTGGTGCCATTTGGGGATGTGGTTGGCTGCCTGGGCATTCATATAAAGAAC
TGCAGACATTTTATGCCTAAGATCAGTTTACAACATTATGCTAATTTATTCATTCGCATCTCTATAAACAAAGCTGTGAAATGTACAAAA
ATGTGTAGCTTGCTATCCAAAAACGATGAGAAGAACACTGTAATTAAGTTCGATGAAGTGAAGTATTTTTCTGTACAGGTTCCCAGACGT
TATGATGATAAGCGGAATAATATTTTATTGGAACTCATACAATATGACAATAGAGAAAAACGTGCTTTCTTGTTAGGGAGTGTTCAGATA
CATCTTTATGAGGTAATTCAGAAAGGGTGCTTCATTGAAGAGGTCCAAGTGTTGCATGGAAACATATTTGTCTGCAGGCTGGAGGTGGAA
TTTATGTTCTCCTATGGAAACTTTGGTTATGGATTTTCACATCAGTTAAAACCTCTTCAGAAAATTACTGAGCCATCCATGTTTATGAAT
CTTGCACCACCTCCAGAAAGAACAGATCCCGTGACAAAAGTTATTACACCACAGACAGTAGAATATCCAGCATTCTTATCCCCAGACCTG
AATGTTACTGTTGGGACTCCAGCTGTGCAATCCTCCAACCAGCCATCTGTAGTGCGACTTGAAAAACTTCAGCAACAACCCCGGGAAAGG
CTGGAAAAGATGAAAAAAGAATATAGAAATCTGAATACATGGATAGATAAAGCTAACTATTTAGAAAGCATTCTAATGCCAAAATTGGAA
CATAAGGATTCTGAGGAAACTAATATAGATGAGGCATCTGAAAACACGAAAAGTAATCATCCTGAAGAGGAGCTTGAAAATATTGTAGGA
GTAGGTGGCTTTTTCACCAAAAGAATATAATTCACCATCTTTCAGACCAGAATATATAGAATTCAAACCAAAATTTCAGGATTGTTCAGA
TAAATTTGAGGATTTACATGACATGACCTCATTTACACACCTTAAAAAAGTAAAATCAAGATCAAGGCTTTTAGGAAAAAGCTCAGATGA
TATCCATAACCATGCCAGACACTCTGCAAGACCATATACTGCTCCGGAGGTTAACAAGCAACGAGAAAGCTACAGTGGAAAGTTTACAAG
TCGTCGAATGGTTTCATCAGGCTTAGTTCATATAAATGATAAAACATCAGATTATGAAATGCATAAAATGCGGCCAAAAAAAATTAAAAG
AGGATATTGAAAAATGTTCGCTCATTTGTGATATTATAAAACATGTTTAACTCAGAATGATATGTGAGGCCAGCAGTCAGAATATCACTT

>31583_31583_3_FTCDNL1-ALS2CR11_FTCDNL1_chr2_200710798_ENST00000420922_ALS2CR11_chr2_202469420_ENST00000439802_length(amino acids)=323AA_BP=5
MLISWMLRKTLKESDSEELEITQETPNLVPFGDVVGCLGIHIKNCRHFMPKISLQHYANLFIRISINKAVKCTKMCSLLSKNDEKNTVIK
FDEVKYFSVQVPRRYDDKRNNILLELIQYDNREKRAFLLGSVQIHLYEVIQKGCFIEEVQVLHGNIFVCRLEVEFMFSYGNFGYGFSHQL
KPLQKITEPSMFMNLAPPPERTDPVTKVITPQTVEYPAFLSPDLNVTVGTPAVQSSNQPSVVRLEKLQQQPRERLEKMKKEYRNLNTWID

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FTCDNL1-ALS2CR11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FTCDNL1-ALS2CR11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FTCDNL1-ALS2CR11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource