Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FTH1-GSPT1 (FusionGDB2 ID:31606)

Fusion Gene Summary for FTH1-GSPT1

Fusion gene summary

Fusion gene information	Fusion gene name: FTH1-GSPT1
	Fusion gene ID: 31606
		Hgene	Tgene
	Gene symbol	FTH1	GSPT1
	Gene ID	2495	2935
	Gene name	ferritin heavy chain 1	G1 to S phase transition 1
	Synonyms	FHC\|FTH\|FTHL6\|HFE5\|PIG15\|PLIF	551G9.2\|ETF3A\|GST1\|eRF3a
	Cytomap	11q12.3	16p13.13
	Type of gene	protein-coding	protein-coding
	Description	ferritin heavy chainapoferritincell proliferation-inducing gene 15 proteinferritin H subunitferritin, heavy polypeptide 1placenta immunoregulatory factorproliferation-inducing protein 15	eukaryotic peptide chain release factor GTP-binding subunit ERF3AG1 to S phase transition protein 1 homologeukaryotic peptide chain release factor subunit 3aeukaryotic release factor 3a
	Modification date	20200329	20200313
	UniProtAcc	P02794	P15170
	Ensembl transtripts involved in fusion gene	ENST00000273550, ENST00000526640, ENST00000529191, ENST00000529631, ENST00000532601,	ENST00000434724, ENST00000439887, ENST00000420576, ENST00000563468, ENST00000564790,
Fusion gene scores	* DoF score	29 X 25 X 6=4350	8 X 8 X 6=384
	# samples	49	13
	** MAII score	log2(49/4350*10)=-3.15016174662088 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/384*10)=-1.5625946876927 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FTH1 [Title/Abstract] AND GSPT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FTH1(61734943)-GSPT1(12009555), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FTH1	GO:0006880	intracellular sequestering of iron ion	9924025
Hgene	FTH1	GO:0048147	negative regulation of fibroblast proliferation	9924025
Tgene	GSPT1	GO:0006479	protein methylation	18539146

Fusion gene breakpoints across FTH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GSPT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-1635-01A	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-

Top

Fusion Gene ORF analysis for FTH1-GSPT1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000273550	ENST00000434724	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000273550	ENST00000439887	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000526640	ENST00000434724	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000526640	ENST00000439887	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000529191	ENST00000434724	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000529191	ENST00000439887	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000529631	ENST00000434724	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000529631	ENST00000439887	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000532601	ENST00000434724	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-3CDS	ENST00000532601	ENST00000439887	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000273550	ENST00000420576	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000273550	ENST00000563468	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000273550	ENST00000564790	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000526640	ENST00000420576	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000526640	ENST00000563468	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000526640	ENST00000564790	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000529191	ENST00000420576	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000529191	ENST00000563468	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000529191	ENST00000564790	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000529631	ENST00000420576	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000529631	ENST00000563468	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000529631	ENST00000564790	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000532601	ENST00000420576	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000532601	ENST00000563468	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-
intron-intron	ENST00000532601	ENST00000564790	FTH1	chr11	61734943	-	GSPT1	chr16	12009555	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for FTH1-GSPT1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FTH1-GSPT1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:61734943/:12009555)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FTH1 P02794	GSPT1 P15170
FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). {ECO:0000250}.	FUNCTION: Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000250\|UniProtKB:Q8IYD1, ECO:0000269\|PubMed:24486019, ECO:0000269\|PubMed:2511002, ECO:0000269\|PubMed:30682371}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for FTH1-GSPT1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for FTH1-GSPT1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FTH1-GSPT1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FTH1-GSPT1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source